CN104366123A - Functional feed for preventing infectious pancreatic diseases in rainbow trouts and production method thereof - Google Patents

Abstract

The invention discloses functional feed for preventing infectious pancreatic diseases in rainbow trouts and a production method thereof. The functional feed comprises fish meal, blood meal, feather meal, soybean meal, shrimp head meal, wheat flour, rice bran, oil, Pagoda tree flower powder, wheat bran, salt, vitamin additive, feed yeast, mineral additive and trace element additive. The production method includes the steps of crushing raw materials, performing mixing, performing granulating and performing drying. Herbal additive having the effects of inducing diuresis, clearing toxicity, tonifying spleen and stopping bleeding and having the effect of treating infectious pancreatic necrosis in the rainbow trouts is added. The functional feed made of green natural herbs and pollution free can directly reach focuses, has significant curative effect and allows the meat of the rainbow trouts to be higher in quality; eating the rainbow trouts has excellent physical healthcare effect.

Description

The functional feed of prevention rainbow trout infectious pancreas infectious disease and preparation method

Technical field

The present invention relates to beasts feed, particularly for preventing functional feed of rainbow trout infectious pancreas infectious disease and preparation method thereof.

Background technology

Infectious pancreatic necrosis (infectious pancreatic necrosis in trout, IPN) is the acute viral disease of a kind of hyperinfection of salmon fishes.Infectious pancreatic necrosis is in Late Cambrian in 1940 in Canadian salmon flying fish, and U.S. grayling also there occurs this disease thereafter, and chief complaint is Pancreatic Necrosis.The people such as nineteen fifty-seven Wolf report that isolated first fishes virus cause of disease is exactly infectious pancreas necrosis virus (IPNV).Infectious pancreatic necrosis is throughout Europe, Asia and America etc.It is reported that the country that this disease occurred has: the countries and regions such as the U.S., Canada, Italy, Japan, Korea S, Norway, Scotland, Czechoslovakia, South Africa, Yugoslavia, China's Mainland and Taiwan Province.

The juvenile fish such as IPNV main harm grayling, rainbow trout, brown trout, silverside and the Atlantic Ocean.The juvenile fish at 3-4 monthly age has the greatest impact, and the death rate is more than 90%.The fish of more than six months does not fall ill.The incidence of disease has larger difference under different conditions.Depend primarily on the kind of host, strain, age, the Virulence Difference of Strain and water temperature.Water temperature is concerning most important fish disease, and 10 DEG C-14 DEG C is onset peak.The larval rainbow having confirmed to infect IPNV will be far smaller than the death rate of 10 DEG C the death rate of 6 DEG C, then lose few 16 DEG C time.Grayling is 46% when the death rate that 10 DEG C are infected IPNV is 74%, 15.5 DEG C, and most fish is not fallen ill 4.5 DEG C time.

Rainbow trout infectious pancreatic necrosis virus to be broken the virus of Aquabirnavirus (Aquabirnavirus) of RNA Viraceae (Birnaviridae) for biplate.Virion is icosahedron, has individual layer capsid, and without cyst membrane, diameter is 55-65nm.Having 4 kinds of structural proteins (VP1, VP2, VP3, VP4), is 1.33g/cm at the buoyant density of CsCl.Double-stranded RNA containing two segments.The resistance of viral environment is to external world extremely strong, to thermally-stabilised, acidproof, insensitive to fatsolvent, EDTA and pancreatin.The appeal of IPNV can keep 230 days in water, reaches 210 days in mud, also reaches 4 weeks when bone dry.The ultraviolet of wavelength 254nm, 35ppm idodine, 2%NaOH solution all can inactivation of viruses.IPN virus has much serotype.

The incubation period of infectious pancreatic necrosis is about 6-10 day.Initial infection is grown well, and the normal fry death rate of appearance raises suddenly, and occurs peeling off suddenly the abnormal swimming positions such as mad trip, rolling, rotation, is stopped at the bottom subsequently, and interval repeats above-mentioned travelling in a moment.Sick fish body blackening in latter stage, exophthalmos ', the obvious enlargement of belly, and hyperemia, hemorrhage can be seen at the base portion of abdomeinal fin, anus often drags a canescence ight soil.

Infectious pancreatic necrosis virus can carry out horizontal transmission by the excreta of fish-egg vertical transmission also by suffering from fish.Although the fish infecting IPNV can produce antibody, some can become the new infection sources with poison throughout one's life.The initial invasion door of horizontal transmission is alimentary canal or the gill.Fry easily infects by soaking, and illustrates that the gill plays an important role.Find that the ovum that the band poison parent population of salmon trout produces and seminal fluid all can be with poison.In vertical transmission process IPN viruses adsorption chorion surface or be hidden in recess, not easily sterilize.And if postlarva hatch after chorion of having eaten will be infected.Be asymptomatic carrier after the salmon flying fish that grows up infects.Can be passed through the lifelong toxin expelling such as excrement, seminal fluid, ovum and urine, the toxic amount in ight soil is the highest, can up to every premium on currency 10TCID50 in the virus of the Chi Shuizhong polluted.Just virus storage is main usually for many non-salmon fishes and shellfish, does not cause morbidity.Cut open inspection and find that liver, spleen obviously fade, alimentary canal noresidue food, the mucus sometimes with milky or yellow in stomach, has petechial hemorrhage at pylorospasm sometimes.

The Histopathological Features of IPN is changed to pancreatic tissues necrosis.Sometimes neighbouring adipose tissue is involved, visible circular or avette intracytoplasmic inclusion in the pancreatic acinar tissue of sex change.With the compromised kidneys of malicious fish, glomerulus is hemorrhage or congested, epithelial cell oedema, destroys or comes off.Intestinal mucosa is impaired, presents the chordapsus with tubulose exudate, and liver is also visible downright bad.Electron microscopic examination ultra-thin section can find virus in liver, pancreas and nephridial tissue, and especially near necrotic area, virion is high-visible.Infected adult fish does not then have the change in pathological anatomy, disappeared by the fish of IPN virus infections its clinical symptom after disease popularity, but still is in carrier state, and constantly scatters virus by urine or the gill.

Doctor trained in Western medicine control infectious pancreatic necrosis, because infectious pancreas necrosis virus is insensitive to ethanol, chloroform, very stable to glycerine, can preserve for a long time in 50%PBS glycerine, pH tolerance range is 4 ~ 10, general comparatively stable in the sour environment of PH5.9, with chloroform (100 ~ 200 mg/kg), formalin (2%), caustic soda (2%), ultraviolet (254 nanometer) and gamma-rays (being greater than 1000 kilorads) process, all can kill infectious pancreas necrosis virus.But prolonged application Western medicine easily produces drug resistance to rainbow trout, and has medicament residue, reduce rainbow trout meat, the course for the treatment of is longer, and clinical therapeutic efficacy is not satisfactory.

The traditional Chinese medical science is thought, The spleen has the function to transport and transform nutrients, refers to that spleen has Jiang Shuigu and turns to precise and tiny, and cereal nutrient is transferred the function to each internal organs of whole body.In fact, spleen is exactly the function of digestion to nutriment, absorption and transport.But, " ying-qi person, secretes its body fluid, note in arteries and veins, change and think blood " (" Ling Shu Miraculous Pivot or Divine Axis evil visitor ")." middle Jiao gives vent to anger as dew, upper note trench, and ooze grandson's arteries and veins, body fluid and tune, change and red be blood " (" Ling Shu Miraculous Pivot or Divine Axis ulcer ").It is blood that body fluid can be changed raw, and continuous supplemental blood amount, is completely full of to make blood." Tianjin is water paddyization also, and its turbid person is blood, and clear person is Tianjin, to moisten internal organs, muscle, train of thought, make qi and blood be able to Zhou Hangtong profit and not stagnant person this also.In all qi and bloods, can not without this, then withered puckery not all right without this " (" reading doctor's random notes qi and blood mentalism "), so profit and loss and the body fluid of blood have substantial connection.

But, Chinese medicine infectious pancreatic necrosis occupies larger advantage, green pure crude drug, pollution-free, do not produce drug resistance, cost price is cheap, can large-area applications, drug effect is gone directly focus, evident in efficacy, can improve the meat of rainbow trout, after consumer has eaten this type of rainbow trout, also can play good health-care effect to its body.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of feed being used for the treatment of the Chinese medicine additive of rainbow trout infectious pancreatic necrosis, the Feed Energy containing this Chinese medicine additive is adopted to overcome the various defects of Chinese medicine of the prior art and Western medicine, the Chinese medicine additive adopted has promoting diuresis to remove toxic substance to the treatment of rainbow trout infectious pancreatic necrosis, effect of invigorating the spleen hemostasis.The present invention adopts green pure crude drug, pollution-free, do not produce drug resistance, cost price is cheap, can large-area applications, drug effect is gone directly focus, evident in efficacy, can improve the meat nutrition of rainbow trout, after consumer has eaten this type of rainbow trout, also can play the advantage of good health-care effect to its body.

In order to realize foregoing invention object, the invention provides a kind of for preventing the functional feed of rainbow trout infectious pancreas infectious disease, wherein, described functional feed comprises following raw material: fish meal, blood meal, feather meal, soya-bean cake, shrimp chaff, wheat flour, rice bran, grease, Chinese scholartree leaf powder, wheat bran, salt, vitamine supplement, fodder yeast, mineral additive and trace mineral supplement.

In described functional feed, the ratio of weight and number of each raw material is: fish meal 9-13 weight portion, blood meal 2-5 weight portion, feather meal 6-8 weight portion, soya-bean cake 21-25 weight portion, shrimp chaff 11-15 weight portion, wheat flour 3-6 weight portion, rice bran 12-15 weight portion, grease 2-4 weight portion, Chinese scholartree leaf powder 6-8 weight portion, wheat bran 38-40 weight portion, salt 0.5-1 weight portion, vitamine supplement 0.5-1 weight portion, fodder yeast 1-2 weight portion, mineral additive 0.1-1 weight portion and trace mineral supplement 0.5-1 weight portion.

Described functional feed also comprises Chinese medicine additive, in described functional feed, the ratio of weight and number of each raw material is: fish meal 9-13 weight portion, blood meal 2-5 weight portion, feather meal 6-8 weight portion, soya-bean cake 21-25 weight portion, shrimp chaff 11-15 weight portion, wheat flour 3-6 weight portion, rice bran 12-15 weight portion, grease 2-4 weight portion, Chinese scholartree leaf powder 6-8 weight portion, wheat bran 38-40 weight portion, salt 0.5-1 weight portion, vitamine supplement 0.5-1 weight portion, fodder yeast 1-2 weight portion, mineral additive 0.1-1 weight portion, trace mineral supplement 0.5-1 weight portion and Chinese medicine additive 5-8 weight portion.

In described functional feed, the ratio of weight and number of each raw material is: fish meal 9 weight portion, blood meal 3 weight portion, feather meal 6 weight portion, soya-bean cake 21 weight portion, shrimp chaff 11 weight portion, wheat flour 6 weight portion, rice bran 12 weight portion, grease 2 weight portion, Chinese scholartree leaf powder 6 weight portion, wheat bran 38 weight portion, salt 0.5 weight portion, vitamine supplement 1 weight portion, fodder yeast 1 weight portion, mineral additive 0.8 weight portion, trace mineral supplement 1 weight portion and Chinese medicine additive 8 weight portion.

Described Chinese medicine additive comprises following raw medicinal material: coriandrum, cape jasmine, dayflower, the root of large-flowered skullcap, the coptis, the bark of ash, kuh-seng, Herba Andrographitis, rhizome of cyrtomium, cymose buckwheat rhizome, sargentodoxa cuneata, field pennycress, Chinese lobelia, brush-cherry seed, lilac daphne, Phytolacca acinosa, pawpaw, play both sides of the street, caulis sinomenii, heroubill, Poria cocos, rhizoma alismatis, cucurbit, hoveniae semoveniae semen, shepherd's purse, hirsute gonostegia herb with root, bambusa textile ginseng, tendrilleaf solomonseal rhizome, China match justicia, dillseed, Han dish, chicken crop, Argemone mexicana and whitebracteole bugle herb.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: coriandrum 10-25 weight portion, cape jasmine 12-20 weight portion, dayflower 10-28 weight portion, root of large-flowered skullcap 13-24 weight portion, coptis 12-20 weight portion, bark of ash 10-23 weight portion, kuh-seng 10-25 weight portion, Herba Andrographitis 12-28 weight portion, rhizome of cyrtomium 6-11 weight portion, cymose buckwheat rhizome 15-25 weight portion, sargentodoxa cuneata 13-20 weight portion, field pennycress 10-25 weight portion, Chinese lobelia 10-20 weight portion, brush-cherry seed 12-25 weight portion, lilac daphne 15-24 weight portion, Phytolacca acinosa 5-12 weight portion, pawpaw 11-20 weight portion, play both sides of the street 10-20 weight portion, caulis sinomenii 14-26 weight portion, heroubill 10-25 weight portion, Poria cocos 11-24 weight portion, rhizoma alismatis 10-20 weight portion, cucurbit 10-25 weight portion, hoveniae semoveniae semen 12-28 weight portion, shepherd's purse 13-25 weight portion, hirsute gonostegia herb with root 10-20 weight portion, bambusa textile ginseng 13-30 weight portion, tendrilleaf solomonseal rhizome 15-28 weight portion, China match justicia 10-25 weight portion, dillseed 12-24 weight portion, Han dish 10-20 weight portion, chicken crop 15-25 weight portion, Argemone mexicana 14-22 weight portion, whitebracteole bugle herb 12-30 weight portion.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: coriandrum 15 weight portion, cape jasmine 20 weight portion, dayflower 18 weight portion, the root of large-flowered skullcap 14 weight portion, the coptis 16 weight portion, the bark of ash 15 weight portion, kuh-seng 15 weight portion, Herba Andrographitis 18 weight portion, rhizome of cyrtomium 6 weight portion, cymose buckwheat rhizome 15 weight portion, sargentodoxa cuneata 15 weight portion, field pennycress 15 weight portion, Chinese lobelia 20 weight portion, brush-cherry seed 15 weight portion, lilac daphne 15 weight portion, Phytolacca acinosa 5 weight portion, pawpaw 15 weight portion, play both sides of the street 14 weight portions, caulis sinomenii 16 weight portion, heroubill 15 weight portion, Poria cocos 14 weight portion, rhizoma alismatis 15 weight portion, cucurbit 15 weight portion, hoveniae semoveniae semen 18 weight portion, shepherd's purse 25 weight portion, hirsute gonostegia herb with root 20 weight portion, 23 weight portions joined by bambusa textile, tendrilleaf solomonseal rhizome 22 weight portion, China's match justicia 23 weight portion, dillseed 24 weight portion, Han dish 20 weight portion, chicken crop 15 weight portion, Argemone mexicana 18 weight portion, whitebracteole bugle herb 22 weight portion.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 84 ~ 92%, adds hot reflux 2 ~ 4 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 84 ~ 92%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline cellulose of its quality 0.2 ~ 0.4 times, 0.05 ~ 0.12 times of lactose, the starch of 0.1 ~ 0.4 times, sieve, mix, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.03 times of dolomol, whole grain, compressing tablet, makes.

In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method of the described functional feed for preventing rainbow trout infectious pancreas infectious disease, wherein, described preparation method comprises the following steps:

The first step, pulverizes raw material stage: by described raw material: soya-bean cake, shrimp chaff, rice bran and wheat bran are pulverized, and grinding particle size is 300 ~ 550mm, makes its fine powder amount reach more than 92% of total material;

Second step, blend step: the raw material after the first step being pulverized and other raw materials add mixer, and mix, incorporation time is 40-60 minute;

3rd step, granulation step: the mixture obtained by second step adds in granulator granulates, and pelleting temperature is set to 70-80 DEG C, and gelatinization degree reaches more than 93%;

4th step, drying steps: the feed granules that the 3rd step obtains is carried out drying, baking temperature is 50-65 DEG C, and drying time is 4-8 hour, and de-water ratio reaches more than 94%.

The invention has the beneficial effects as follows: adopt the Feed Energy containing this Chinese medicine additive to overcome the various defects of Chinese medicine of the prior art and Western medicine, the Chinese medicine additive adopted has promoting diuresis to remove toxic substance to the treatment of rainbow trout infectious pancreatic necrosis, effect of invigorating the spleen hemostasis.The present invention adopts green pure crude drug, pollution-free, do not produce drug resistance, cost price is cheap, can large-area applications, drug effect is gone directly focus, evident in efficacy, can improve the meat nutrition of rainbow trout, after consumer has eaten this type of rainbow trout, also can play the advantage of good health-care effect to its body.

Detailed description of the invention

Chinese medicine additive refers to take as the leading factor with the traditional theory of China to the physical property of the Nature Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation and with the subjects theory such as raising and feed industry and technology for support, the single and compound Chinese herb feed additive developed or intermixture.From modern pharmacology Epidemiological Analysis, feed addictive based on Chinese herbal medicine effective ingredients, there is the immunologic function and non-specific antimicrobial effect that regulate body, Chinese herbal medicine contains alkaloid, polysaccharide, two class volatile oil, the bioactivator such as organic acid flavones and bioflavonoid of anti-antibacterial composition, to adjustment human body immune function, good effect of improving health conditions.It is reported, ward off more and there is the reaction of promotion thymus gland, stimulation reticuloendothelial cell raising specific antigen respond; Alkaloid can strengthen body fluid and cellular immune function, and the phagocytic function of stimulating expression of macrophage, two classes can strengthen the phagocytic function of reticuloendothelial system, and can generate by enhancing antibody, promote antigen-antibody reaction and lymphocyte transformation organic acid, intestines can be regulated interior and prevent the breeding of harmful bacteria and improve the activity of enzyme, animal body intracellular metabolic can normally be carried out.The nutriment of folding Chinese herbal feed additive not only containing some is divided from the theory of modern nutriology, but also contain unknown growth regulator and the pigment of some, there is the biochemical reaction activating body directly or indirectly, strengthen biosynthesis effect, thus promote the production performance of animal.

Chinese medicine additive of the present invention follows promoting diuresis to remove toxic substance, the object of invigorating the spleen hemostasis, provide a kind of for preventing the functional feed of rainbow trout infectious pancreas infectious disease, it comprises Chinese medicine additive, Chinese medicine additive comprises following raw medicinal material: coriandrum, cape jasmine, dayflower, the root of large-flowered skullcap, the coptis, the bark of ash, kuh-seng, Herba Andrographitis, rhizome of cyrtomium, cymose buckwheat rhizome, sargentodoxa cuneata, field pennycress, Chinese lobelia, brush-cherry seed, lilac daphne, Phytolacca acinosa, pawpaw, play both sides of the street, caulis sinomenii, heroubill, Poria cocos, rhizoma alismatis, cucurbit, hoveniae semoveniae semen, shepherd's purse, hirsute gonostegia herb with root, bambusa textile is joined, tendrilleaf solomonseal rhizome, China's match justicia, dillseed, Han dish, chicken crop, Argemone mexicana and whitebracteole bugle herb.Wherein, wherein, coriandrum, cape jasmine, dayflower, the root of large-flowered skullcap, the coptis, the bark of ash, kuh-seng heat-clearing and damp-drying drug; Herba Andrographitis, rhizome of cyrtomium, cymose buckwheat rhizome, sargentodoxa cuneata, field pennycress, Chinese lobelia removing toxic substances, dehumidifying, hemostasis; Brush-cherry seed, lilac daphne, Phytolacca acinosa Li Shui, defaecation; Pawpaw, play both sides of the street, caulis sinomenii, heroubill be clearing heat and detoxicating; Poria cocos, rhizoma alismatis, cucurbit, hoveniae semoveniae semen, shepherd's purse, chicken crop, Argemone mexicana and whitebracteole bugle herb inducing diuresis for removing edema; Hirsute gonostegia herb with root, bambusa textile ginseng, tendrilleaf solomonseal rhizome, China's match justicia, dillseed, with Han dish invigorating the spleen removing toxic substances, make a general survey of full side's compatibility science, rigorous, can strengthen the resistance against diseases of rainbow trout while disinfecting detoxifying.

Now each taste Chinese medicine pharmacology is described below:

Coriandrum: have another name called caraway.Pungent, temperature.Attach to the lung and stomach meridians." Roche about can cure mirror ": " ward off all not gas just, dispersing wind and cold, fever and headache, the paddy that disappears food is stagnated, and along two just, goes order screen, increasingly acne rash." there is sweating promoting eruption, the merit of promoting digestion to eliminate stagnation, be applicable to flu, children's measles or rubella and thoroughly send out not smooth, eating accumulation, indigestion etc.Caraway is nutritious, and caraway includes vitamin c, carrotene, vitamin b1, b2 etc., simultaneously also containing abundant mineral matter, as calcium, iron, phosphorus, magnesium etc.Also containing potassium malate etc. in caraway.The amount of the vitamin c contained in caraway is more much higher than common vegetable, and common people eat 7 ~ 10 grams of caraway leaves just can meet the demand of human body to vitamin c; Carrotene contained in caraway exceeds more than 10 times than tomato, Kidney bean, cucumber etc.

Cape jasmine: bitter, cold, nontoxic; Enter the heart channel of Hang-Shaoyin, Liver Channel, lung channel, stomach warp, tri-jiao channel.Shennong's Herbal: " perverse trend in main five, pathogenic heat in the stomach gas, flushing wine blister Cha nose, the red impetigo ulcer of white leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the red pain of order heat, the large heat of chest heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.Pyreticosis is vexed, irascibility hot eyes, and headache, jaundice with damp-heat pathogen, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt fire-evil, purge the sthenic heart-fire and relieving restlessness, the key medicine that pyreticosis is vexed in order to control, dysphoria is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels liver and gallbladder damp-heat, availablely control the hot and suffocating jaundice of liver and gallbladder damp-heat, scanty drak urine person.The hypotensive activity position of cape jasmine, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Dayflower: sweet, cold, light; Enter the heart, all warps of liver,spleen,kidney, intestine and small intestine.Supplement to the Herbal: " fourth swells, and meat disease is not smooth, infantile erysipelas, mad epilepsy of generating heat for main fever and chills malignant malaria, phlegm and retained fluid, and large abdomen ruffian is full, and body face wind-puff, hot dysentery, dog stings snake, the poison such as ulcer." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " invigorating QI and blood, treat married woman leukorrhea, redly to collapse, raw new blood, only hematuria, nosebleed epistaxis blood, blood drench." for fever caused by exogenous pathogens, or febrile disease heating is not moved back, or abscess of throat, and carbuncle swells the diseases such as sore.For difficult urination, oedema, or wet into diseases such as bet bladder, the puckery pains of dribbling urination.The water logging agent of congener cauline leaf or decoction can excited uterus, vasoconstriction, and can the clotting time be shortened.

The root of large-flowered skullcap: property is bitter, cold.Return lung, courage, spleen, large intestine, small intestinl channel." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and radix bupleuri is best, so can not reach table by cool flesh without the root of large-flowered skullcap.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so the house root of large-flowered skullcap can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with detoxify and promote granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section is semi-exterior-interior, agent is also." can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, and rush down dysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.The root of large-flowered skullcap has antipyretic, calm, hypotensive, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, typhoid bacillus, dysentery coccus, ewcastle disease, Pseudomonas aeruginosa, there is certain inhibitory action, have good curative effect to the infection of the upper respiratory tract, chronic bronchitis, bacillary dysentery etc.

The coptis: bitter, cold, nontoxic.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel." drug property cerse ": " bitter, flat, gas is trembled with fear, nontoxic.Sink also, the moon also.It is with having four: purge the sthenic heart-fire, the shape that the epigastric fullness that disappears is full; Main intestines Bleach is red except what mix in intestines; Control order disease to break out and should use, treat sore head and the tail all same." function heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, vomiting acid regurgitation, rushes down dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing the heart-fire stomach, and have preventing or arresting vomiting concurrently and to disappear the merit of ruffian, can be used for the prosperous caused dysphoria and insomnia for the treatment of internal heat, blood-head tells nosebleed, hot eyes, has a toothache, quenches one's thirst, and carbuncle swells furunculosis; Control eczema outward, wet sore, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach preventing or arresting vomiting.Tie mutually for fever and chills, damp and hot middle resistance, ruffian is completely vomitted.The cornel coptis is relaxed liver and stomach preventing or arresting vomiting.For liver-stomach disharmony, vomiting acid regurgitation.

The bark of ash: bitter, cold; Return Liver Channel, gallbladder channel, large intestine channel." book on Chinese herbal medicine converges and says ": " bark of ash, bitter is puckery and hard, can restrain the vital essence of wandering away.Therefore Zhong Jing baitouweng decoction, control the inferior burnt abnormal heat and sharp person with this, get bitter with puckery meaning also." Compendium of Material Medica: “ Ash skin, look clear gas is trembled with fear, and bitter is puckery, is faint cloudy liver, few positive gallbladder channel medicine also.Therefore control order disease, frightened epilepsy, get its flat wood also; Control the inferior dysentery, collapse band, get its inducing astrigency also; The few essence of man can be controlled again, beneficial essence has son, all get that it is puckery and have benefit also." Shennong's Herbal: " heat extraction, blue or green screen tunica albuginea in order." function heat-clearing and damp-drying drug, clear liver and improve vision, inducing astrigency stops dysentery, only band.Dysentery is rushed down, the lower pruritus vulvae of band, the hot red eye, swell pain of liver, the raw ocular of order for hot poison.

Kuh-seng: the effect having anti-inflammation, all has inhibitory action to Propiobacterium, staphylococcus aureus, Escherichia coli, can diuresis, antiallergy, ease pain, relieving asthma, eliminate the phlegm.Bitter; Cold in nature.Return liver; Kidney; Large intestine; Small intestinl channel; Bladder; The heart channel of Hang-Shaoyin; Urinary bladder channel.Effect: heat-clearing and damp-drying drug: extensive use and multiple humidifier fever, as damp-heat dysentery external application can decoct soup washout, for hemorrhoid, women gynaecology; Desinsection (external application), diuresis.Can heat-clearing and damp-drying drug; Wind dispelling insecticide.Main damp-heat dysentery; Hematochezia; Jaundice; Difficult urination; Oedema; Under band; Pruritus vulvae; Mange; Leprosy; Pruitus; Eczema of lower limb ulcer.Compendium of Material Medica is said: " bitter cold of kuh-seng, golden cypress, all can kidney tonifying, and lid gets its bitter eliminating dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind desinsection can be controlled again.Only kidney water is weak and mutually fiery victor is suitable with it, the cold sperm if fire declines, and true strength is not enough, and year high people is also unavailable.ZHANG Cong-zheng is cloud also, all medicines all poison also, though Radix Glycyrrhizae, kuh-seng, can not poison unexpectedly, take for a long time, the five tastes respectively return it dirty, must have the trouble of victory gas increasings partially, and all medicines are all right, scholar's length when tactile class can also, as the same as diet.Again by " Records of the Historian " cloud, the sick carious tooth of granary public Chunyu Yi doctor doctor Qi, moxibustion left hand yangming meridian, gargles three liters with kuh-seng soup day, careful wind of coming in and going out, and more this also got the justice that it removes the damp and hot desinsection of general mood on five, six ".

Herba Andrographitis: have another name called Chun Lianqiuliu, Banlangen, Lan Helian, andrographis paniculata, golden vanilla, golden tack, India's grass, eel grass etc.There are clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.Cure mainly bacillary dysentery, urinary tract infections, acute tonsillitis, enteritis, sphagitis, pneumonia and influenza etc., external application can treat sore furuncle poison, trauma infection contamination etc.Herba Andrographitis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, the infection of the upper respiratory tract, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infections, endometritis, pelvic infecton, tympanitis, periodontitis etc., all have curative effect in various degree.

Rhizome of cyrtomium: nature and flavor are bitter, are slightly cold.Return liver, the spleen channel.Have clearing heat and detoxicating, cooling blood and hemostasis, effect of desinsection.Anemopyretic cold can be cured mainly, febrile virulent maculae; Blood-head is hemorrhage; Worm disease; This product also can be used for treatment burn and scald and married woman is with inferior disease.Shennong's Herbal cloud: " main abdomen be possessed hot gas, all poison, kill three worms ".Main containing bright and beautiful Ma Su, Tectaria subtriphlla (Hook. Et Arn.) powder, flavaspidic acid, bright and beautiful horse hypo acid, volatile oil, bright and beautiful horse tannin etc.Bright and beautiful horse acid contained by this product, yellow bright and beautiful horse acid have stronger anthelmintic action, have strong toxicity, hookworm can be made to benumb and discharge, also have and drive away the parasitic effect such as hookworm, roundworm tapeworm.According to clinical report, rhizome of cyrtomium has good therapeutic effect to multiple disease of viral infection, is widely used in the Prevention and Curation of flu, influenza and the infection of the upper respiratory tract.

Cymose buckwheat rhizome: cool in nature, taste is pungent, bitter.Can be clearing heat and detoxicating, the carbuncle that disappears of invigorating blood circulation, sore of dispelling rheumatism, snake bite and insect sting.Main lung carbuncle, lung heat is coughed and is breathed heavily, abscess of throat, dysentery, rheumatism bi Zheng, traumatic injury, carbuncle cancer.Though experiment in vitro is without obvious antibacterial action, antagonism is have to the coagulase of staphylococcus aureus, hemolysin and Pseudomonas aeruginosa endogenous toxic material.

Sargentodoxa cuneata: bitter, property is put down, and returns liver, large intestine channel, " Hunan medicine will ": " stimulate the menstrual flow and enrich blood, strengthen muscles and bones, expelling parasite.Control traumatic injury, rheumatalgia pain, bruise, blood drenches, arthralgia and myalgia, sore furuncle, filariasis." " simple and easy herbal medicine ": " control arthralgia and myalgia, chase after wind, strong waist knee, establishing-Yang thing." there is the carbuncle that disappears that relieves internal heat, promoting blood circulation and removing obstruction in channels, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, arthralgia due to wind-dampness, dysentery characterized by blood in the stool, and blood drenches, irregular menstruation, infantile malnutrition due to digestive disturbances or intestinalparasites, worm pain, the cards such as injury from falling down.Ba Mushi isolated heart device is pressed to the effect of Isolated Toad Heart, with 20ml ringer solution perfusion, 0.1g Sargent gloryvine is added (0.5%) in perfusate, find to suppress in slight isolated heart, performance heart contracting power weakens, and decreased heart rate (P0.05), cardiac output reduces (P0.01).To the effect of isolated rabbit aortic article by the aortic article of isolated rabbit, result blood vessel starts to occur obvious contraction, and this effect can be blocked by phentolamine, points out its contraction may be receptor related with a-.Gradually there is lasting relexation again subsequently.

Field pennycress: taste is pungent, bitter, is slightly cold; Return liver, stomach, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cool blood-head, cold stomach are sent out in tripe abdomen all long-pending, diuresis.Compendium of Material Medica: " control blood and drench hemorrhoid complicated by anal fistula." Tang Materia Medica: " Patrinia scaniosaefolia, does not go out shortcut, and between Duo Shenggang ridge, leaf is like water Liang and common vetch rank, and grow thickly, brightly yellowish, root purple makes old dark reddish brown; Its leaf different Bu Si pig Xian also." function is clearing heat and detoxicating, cool blood, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing, for acute appendicitis, the high heat of lung carbuncle, coughs vomiting of pus and blood, hot carbuncle malignant boil, and sore furuncle pain is swollen, chest abdomen pain, appendicitis, enteritis, dysentery, postpartum abdominal pain, dysmenorrhoea.

Chinese lobelia: taste is sweet; Property is put down.Thoughts of returning home warp, lung channel, small intestinl channel." Luchuan book on Chinese herbal medicine ": " detoxicating, relieving inflammation, diuresis, hemostasia and promoting granulation.Control ascites, child convulsion, two unilateral tonsillitis, dermatitis rhus, traumatism and bleeding, skin mange, snake honeybee scorpion hinders." function is clearing heat and detoxicating, inducing diuresis for removing edema.Cure mainly in venomous snake bite, carbuncle swells furunculosis, tonsillitis, warm rash, tinea pedis, traumatic injury, jaundice with damp-heat pathogen, appendicitis, enteritis, ephritis, cirrhotic ascites and kinds cancer.

Brush-cherry seed: pungent, bitter, sweet, flat.Return spleen, large intestine, small intestinl channel.Function cures mainly: moisturize laxation, lower gas, Li Shui.For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, oedema, beriberi, difficult urination.Contained by brush-cherry seed, brush-cherry seed glucoside has strong discharge function to animal used as test.The protein component IR-A raised from brush-cherry seed and IR-B intravenously administrable have anti-inflammatory and analgesic activity.Brush-cherry seed has the significant effect promoting small bowel peristalsis. and strongly fragrant Lee's glucoside has strong discharge function to animal used as test, also has calmness and diuresis.Strongly fragrant Lee's glucoside and Senna Fructus are both large intestine purgatives, but the former side effect is little compared with the latter.

Lilac daphne: bitter, acrid, cold; Return lung, spleen, kidney channel." property of medicine opinion ": " control trusted subordinate's turgor, anhydrate gas, and sharp the five internal organs are trembled with fear phlegm, and tears saliva is as glue person.Main promoting blood circulation, control and dislike sore wandering arthritis and wet, all malicious wind, four limbs contraction is anxious, can not go step, can water pouring swelling completely." " herbal classic ": " main cough with dyspnea, laryngeal stridor is breathed heavily, and pharynx is swollen loses heart, terrible malaria, and hernia lump in the abdomen, carbuncle swells." desinsection detoxifies for removing water retention by purgation, expelling phlegm and arresting coughing.Cure mainly oedema tympanites, the phlegm and retained fluid hypochondriac lump, hypochondriac pain of breathing with cough, carbuncle furuncle mange.Vinegar lilac daphne and the benzene lilac daphne alcohol aqueous extract of in vitro test 1:50 concentration all have inhibitory action to pneumococcus, Streptococcus hemolyticus, hemophilus influenzae.Faint from fear in experiment at anti-strychnine or caffeine sodium benzoate, have obvious anticonvulsant action, the peaceful convulsion effect of anti-soil is stronger; In addition, lilac daphne obviously can also strengthen the anesthetic effect of amobarbital sodium to dog.

Phytolacca acinosa: its bitter, cold in nature, return lung, kidney, large intestine channel.To relieve oedema or abdominal distension through diuresis or purgation detumescence, smoothening secretion, the function of detoxicating and resolving a mass.Cure mainly oedema turgor, constipation and anuresis, scrofula, sore etc.This savors decoction, tincture, water logging agent have obvious phlegm-dispelling functions to mouse stomach.Mouse ammonia spraying draws to be coughed experimental method and proves: Phytolacca acinosa slightly carries that alkaloid is oral obvious antitussive effect.This product root extract perfusion toad kidney or directly instillation frog kidney, can make urine volume increase, and its mechanism of action may be stimulate vasomotor center, telangiectasis, and CBF increases, and makes the result that kidney blood circulation is accelerated.The triterpenic acid extracted from Phytolacca acinosa has antiinflammatory action, similar to hydrocortisone to the antiinflammation of rat swollen feet.Phytolacca acinosa infusion has the effect killing Ability of Culex Pipiens Larvae.

Pawpaw: taste acid, warm in nature, nontoxic; Return liver, the spleen channel." modern Practical Chinese medicinal ": " crude fruit liquid, controls gastric indigestion, and is nutriment, is again agent of stimulating the secretion of milk.Ripe fruit, can sharp stool and urine, also can control red-white dysentery." " food book on Chinese herbal medicine ": " main sharp gas, loose stagnant blood, treats pained, antipyretic strongly fragrant." pawpaw has the effect of stimulating the circulation of the blood and cause the muscles and joints to relax preferably, and energy dampness elimination, commonly used by controlling arthralgia due to wind-dampness, muscle arteries and veins contraction person particularly key medicine.Papaya powder can alleviate the liver cell fatty degeneration and necrosis of liver cells that rat skin lower injection carbon tetrachloride causes, and prevents swelling of liver cell and balloon sample from becoming, can promote hepatocellular reparation, SGPT is significantly reduced.There is remarkable inhibitory action to multiple enteron aisle bacterium and staphylococcus, also have obvious inhibitory action to Diplococcus pneumopniae and tubercle bacillus.Carpaine has the effect alleviating spasm pain, has obvious therapeutic action for systremma.

Play both sides of the street: bitter, flat; Return liver, kidney channel." detailed outline is picked up any lost article from the road ": " maple fruit, tree is like white poplar, and inner circle, as honeycomb, namely plays both sides of the street.The large acupoints of twelve meridians that can pass through of its property, therefore " the lifesaving sea of bitterness " harnesses the river, swelling is with it, can search by Fu Shuiye with it." " modern Practical Chinese medicinal ": " ashing is outer for skin exudative dermatitis, anal fistula etc., has convergence, anti-inflammatory, disinfective action." dispelling, collateral-activating, Li Shui stimulates the menstrual flow.For joint pain, numbness contracture, oedema turgor, breast is few through closing.

Caulis sinomenii: bitter, pungent; Return liver, the spleen channel.Compendium of Material Medica: " control rheumatism streamer, go through joint crane knee, paralysis itch, damage sore swells, and enters in yeast for brewing rice wine and uses." " will planted by Tianmu Mountains of Zhejiang Province medicine ": " row water diuresis, it is damp and hot to rush down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system.Control edema caused by wind, beriberi, Fengshi Guanjie pain, facial paralysis, carbuncle is swollen dislikes sore." function wines used as antirheumatic, stimulate the menstrual flow network, diuresis.For arthralgia due to wind-dampness, arthroncus, paralysis itch.Sabia japonica dispersing wind and cold arthritis with fixed pain caused by dampness, can relax the muscles and stimulate the blood circulation, and boneset sharp marrow, therefore wind disease is weak and feeble, and the card that strength is attached undue importance to one thing to the neglect of the other by force, take informal dress for a long time, make outstanding contributions greatly.Cucoline, in the test with mouse electrostimulation, hot plate method and rabbit photo-thermal stimulus method, all proves the analgesic activity with affirmative.Sinomenium acutum total alkali is to anesthesia or not anaesthesia experiment animal (dog, cat, rabbit, rat), and intravenous injection or gavage all have the acute antihypertensive effect of affirmative.

Heroubill: bitter, micro-pungent is flat.Return liver, kidney, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control meridian hectic fever, dizzy, be afraid of cold, limbs are aching and tired, distaste for food, the virgin infantile malnutrition due to digestive disturbances or intestinalparasites of male heroubill woman, deficient fever do not move back person with it, diuresis, buffalo meat is for drawing." remove rheumatism, for arthralgia due to wind-dampness.The extract of the wild heroubill root of heroubill contains flavonoids, catechin, tannin, and wherein the effect of resisiting influenza virus is the most obvious to suppress copy (as influenza, herpe simplex, cowpox, the HIV-I) of multiple virus.Heroubill can suppress liver mitochondrion and MC lipid peroxidation, reduces plasma cholesterol and GOT/GPT level, suppresses the mitochondrial lipid peroxidation effect brought out by ADP and ascorbic acid.The sterile water solution of heroubill extract all has inhibitory action to shigella flexneri, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa in vitro.

Poria cocos: sweet, light is flat.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Function: sharp water medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria cocos, the sharp key of light energy.The sweet flat yang-tonifying of taste, beneficial spleen is relieved oedema or abdominal distension through diuresis or purgation, air guide of promoting the production of body fluid." modern study shows that the effect that Poria cocos has a develop immunitypty can many-sided regulate immunologic function.Poria cocos has significant inhibitory action to staphylococcus aureus, proteus.

Rhizoma alismatis: taste is sweet, light, cold in nature, enters kidney, urinary bladder channel, and theory of traditional Chinese medical science thinks that it is cold in nature, has clearing damp and promoting diuresis, the lung that clears away heart-fire, rushes down effect of kidney fire.Be mainly used in insufficiency of the spleen retention of water-damp, the wet anasarca of spreading unchecked of water; Heresy that water drink phlegm is wet is tired to be hindered, and what cause that lucid yang failing to raise voiced sound do not fall is dizzy; The difficult urination of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice with damp-heat pathogen.Modern medicine study, rhizoma alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.

Cucurbit: bitter, temperature; Return kidney channel.《 Jiayou Bencao ": " the dirty empty cold air of pivot.Monkshood, Sulfur, control suffer from a deficiency of the kidney cold, abdomen the side of body turgor, greenish complexion is black; The fragrant son of get Huai, peach kernel, control bladder gas." " detailed outline ": " control cold air hernia lump in the abdomen, the disturbance of lower legs due to pathogenic cold and dampness; The right kidney of benefit, warm public region.There are kidney tonifying wind dispelling, supporing yang analgesic effect, have refreshing people's body and mind, quiet brain calmed the nerves, lax nerve, relieving fatigue, remove obstruction in channels to relieve pain, the effect of replenishing vital essence to tonify kidney establishing-Yang, be usually used in treating impotence involuntary emission, have a pain in the back, the illness such as young married woman's dysmenorrhoea, the hernia swelling and hanging down of either of the testes, the disturbance of lower legs due to pathogenic cold and dampness.

Hoveniae semoveniae semen: property is put down, and taste is sweet.Enter the heart channel of Hang-Shaoyin, the spleen channel.Supplement to the Herbal: " sharp stool and urine, go heat on diaphragm, function is as honey for relieving restlessness of quenching the thirst, moisturizing viscera." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control the right paralysis of all left paralysiss, rheumatic numbness, energy relieving alcoholism; Also can relaxing muscles and tendons network.Children's takes it, changes worm, supports spleen." relieving restlessness of quenching the thirst, disappear damp and hot, relieving alcoholism.To vomit inverse, difficulty in urination and defecation for middle wine poison, polydipsia.Hoveniae semoveniae semen has significant diuresis, and hoveniae semoveniae semen saponin has hypotensive effect, and hoveniae semoveniae semen homogenate has lipoid peroxidization resistant and strengthens cold-resistant and heat-resisting function.Containing a large amount of glucose, organic acid in hoveniae semoveniae semen, the blood volume of human body can be expanded, again can relieving alcoholism, therefore have the effect of sobering up and calming the nerves.Containing a large amount of calcium and hoveniae semoveniae semen saponin in hoveniae semoveniae semen, there is central inhibitory action, can be anticonvulsion, prevent tetany spasm, can be used to the disease for the treatment of arthralgia due to wind-dampness numbness.

Shepherd's purse: be slightly cold is sweet, light.Energy cooling blood and hemostasis, promoting urination and removing dampness, clears liver and improve vision." modern Practical Chinese medicinal ": " hemostasis, controls empsyxis, uterine hemorrhage, miscarry hemorrhage, menorrhalgia, headache, order pain or retinal hemorrhage." shepherd's purse has the effect of similar ergot.Its medicinal extract is tried out and to be left one's post uterus or intestinal tube in animal, all in significantly shrinking.The alcohol extract of shepherd's purse, to dog, cat, rabbit, rat intravenous injection, can produce transient blood pressure and decline, and this effect is not by 80 μ g/kg atropine institute antagonisms.

Hirsute gonostegia herb with root: nature and flavor sweetness and bitterness is cool.1. " Kweiyang medicinal herbs among the people ": " misery, cold, nontoxic." 2. " Traditional Chinese Medicine in Sichuan product ": " property is put down, lightly seasoned, nontoxic." 3. " Fujian Chinese herbal medicine ": " sweet micro-hardship, cool." cure mainly clearing heat and detoxicating, invigorating the spleen, hemostasis.Treatment sore, carbuncle swells, scrofula, dysentery, women leukorrhea, infantile malnutrition, spits blood, traumatism and bleeding.1. " Tian Bao book on Chinese herbal medicine ": " control to fall and injure, scrofula of itching, all sore ulcer carbuncle on the back." 2. " mount emei medicine is planted ": " root: mash, applies and controls weapons wound." 3. " Guizhou side's medicine among the people lamp stand ": " qi-restoratives, lactagogue." 4. " conventional glossary of Herbs and Drugs among the people ": " increase blood, strengthening the spleen and stomach, Gu in nourish blood.For oral administration the controlling of fricassee has a weak heart." 5. " Traditional Chinese Medicine in Sichuan will ": " strengthening spleen, tonifying kidney.Control breast inflammation and infantile malnutrition." 6. " Guizhou herbal medicine ": " is clearing heat and detoxicating, and invigorating the spleen disappears long-pending, hemostasis.Control furunculosis, nine sub-ulcers, infantile indigestion with food retention turgor, traumatism and bleeding." 7. " Yunnan Chinese herbal medicine ": " synthetism myogenic, anti-inflammatory antidiarrheal.Control dysentery, dysmenorrhoea." 8. " Fujian Chinese herbal medicine "; " clearing heat and cooling blood, subdhing swelling and detoxicating.Control haematemesis, damp and hot leukorrhea, boil on the nape, treating swelling and pain by traumatic injury."

Bambusa textile is joined: nature and flavor are sweet; Flat.Cure mainly nourishing Yin and clearing heat; Invigorating the spleen; Hemostasis.Main fever due to yin deficiency; Spontaneous perspiration; Night sweat; Body void is weak after being ill; Food is few; Spit blood.

China's match justicia: nature and flavor are micro-sweet; Bitter; Slightly warm in nature.Cure mainly spleen benefiting and stimulating the appetite; Loose stasis of blood hemostasis; Subdhing swelling and detoxicating.Main body void is weak; Poor appetite; Spit blood; Bleeding from five sense organs or subcutaneous tissue; Fall and beat stasis of blood pain; Sore swollen toxin; Snakebite.

Dillseed: nature and flavor are pungent, temperature.1. supplement to the Herbal: " pungent, fragrant." 2. " Kaibao Bencao ": " taste is pungent, temperature, nontoxic." return through entering spleen, kidney channel.1. " medicineization justice ": " enter liver, kidney, bladder three warp." 2. " book on Chinese herbal medicine is through separating ": " enters the liver channel of foot-Jueyin, lung meridian." 3. " book on Chinese herbal medicine is looked for the truth ": " enters liver, stomach, kidney, bladder, small intestine." 4. " book on Chinese herbal medicine is new again ": " enters spleen, stomach, kidney three warp." cure mainly warm spleen kidney, appetizing, loose cold, promoting the circulation of qi, separates ichthyosacrotoxin.Control acute diseases such as cholera and sunstroke dirty vomit inverse, crymodynia in abdomen, cold hernia, the completely few food of ruffian.1. supplement to the Herbal: " children's's inflatable, cholera is vomitted inverse, and the cold not lower food of abdomen, both sides of the chest ruffian is full." 2. " Haiyao Bencao, Oversea Materia Medica ": " main diaphragm gas, helps digestion, warm stomach, and kind taste food flavor, many foods are harmless." 3. " Japan hanako materia medica ": " invigorating the spleen, appetizing gas, warm intestines, kill ichthyosacrotoxin, and moisturizing is dirty and strengthen the bone, and controls kidney qi." 4. " medical center bun is wanted ": " profit kidney kidney tonifying, mend the gate of vitality, warm public region, appetizing above reaches Danzhong in adjusting, and edema with the liver involved of relaxing reaches gloomy, relaxing muscles and tendons, lower to beriberi, controls cold hernia." 5. " occupying diet spectrum with breath ": " warm stomach invigorating the spleen, eliminating cold to stop pain, desinsection helps digestion, regulating the qi flowing in the channels preventing or arresting vomiting, determines waist, tooth pain, separates ichthyosacrotoxin."

Han dish: another name edible wild herbs, iron vegetable seeds, sarson, Herba Rorippae, barbarea, cowpea.Ten Zi Hua section Han dish platymiscium Han dish Rorippa montana (Wall.) Small or river adjoin clinopodium herb Rorippa indica (L.) Hiern., with all herbal medicine.Xia Qiu gathers, and dries.Nature and flavor are sweet, light, cool.Cure mainly clearing heat and detoxicating, antibechic, diuresis.For cold, fever, abscess of throat, cough with lung heat, chronic bronchitis, acute rheumatic arthritis, hepatitis, difficult urination; Dermatitis rhus is controlled in external application, snake bite, and furunculosis carbuncle swells.

Chicken crop: nature and flavor are bitter is flat.1. " Kunming conventional herbal medicine among the people ": " property is put down, bitter." 2. " Yunnan Chinese herbal medicine ": " is pained, cool." cure mainly clearing heat and detoxicating, Li Shui, desinsection.Control hepatitis, ascites, roundworm disease, burn and scald.1. " Kunming conventional herbal medicine among the people ": " disappear long-pending getting rid of intestinal parasites by means of drugs." 2. " choosing of Yunnan Chinese herbal medicine ": " row water, anti-inflammatory, cholagogic, desinsection." 3. " Yunnan Chinese herbal medicine ": " is clearing heat and detoxicating."

Argemone mexicana: nature and flavor are pungent; Bitter; Cool.Return through spleen, lung, courage three warp.Cure mainly sweating Li Shui, clearing heat and detoxicating, antalgesic-antipruritic.。Main flu is lossless, yellow wash with watercolours, gonorrhoea, oedema, laceration of eyelid, colic, and scabies is insane, syphilis.

Whitebracteole bugle herb: nature and flavor " Chinese herbal medicine is commonly used in Tibet ": " bitter, cold." returning through " plateau Chinese herbal treatment handbook ": " enters liver kidney two warp." cure mainly clearing heat and detoxicating, activating blood circulation and reducing swelling.Cure cold wind-heat, abscess of throat, cough, spits blood, hypertension, facial paralysis, falls and beat stasis of blood pain.1. " Chinese herbal medicine is commonly used in Tibet ": " clearing heat and detoxicating, promoting diuresis for stranguria, cool blood step-down.Control affection of exogenous wind-heat, hypertension, sphagitis, bronchitis, lithangiuria, sore and toxic." 2. " Qinghai-Tibet medicine illustrated handbook ": " detoxifies.Control influenza, Poisoning liver damage and liver stomach complication." 3. " plateau Chinese herbal treatment handbook ": " is antipyretic antibacterial, activating blood circulation and reducing swelling.Control fall damage the stasis of blood coagulate, facial paralysis mouth is askew, epersalgia cough, spit blood, gas pain sterilization, anthrax."

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese medicine additive

Coriandrum 15 weight portion, cape jasmine 20 weight portion, dayflower 18 weight portion, the root of large-flowered skullcap 14 weight portion, the coptis 16 weight portion, the bark of ash 15 weight portion, kuh-seng 15 weight portion, Herba Andrographitis 18 weight portion, rhizome of cyrtomium 6 weight portion, cymose buckwheat rhizome 15 weight portion, sargentodoxa cuneata 15 weight portion, field pennycress 15 weight portion, Chinese lobelia 20 weight portion, brush-cherry seed 15 weight portion, lilac daphne 15 weight portion, Phytolacca acinosa 5 weight portion, pawpaw 15 weight portion, play both sides of the street 14 weight portions, caulis sinomenii 16 weight portion, heroubill 15 weight portion, Poria cocos 14 weight portion, rhizoma alismatis 15 weight portion, cucurbit 15 weight portion, hoveniae semoveniae semen 18 weight portion, shepherd's purse 25 weight portion, hirsute gonostegia herb with root 20 weight portion, 23 weight portions joined by bambusa textile, tendrilleaf solomonseal rhizome 22 weight portion, China's match justicia 23 weight portion, dillseed 24 weight portion, Han dish 20 weight portion, chicken crop 15 weight portion, Argemone mexicana 18 weight portion, whitebracteole bugle herb 22 weight portion.

Its preparation method comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 84%, adds hot reflux 2 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 times to be again the ethanol of 84%, to add hot reflux 1 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 hour, pulverize, sieve, obtain 200 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline cellulose of its quality 0.2 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix, granulate, dry, add relative to micropowders quality 0.001 times of dolomol, whole grain, compressing tablet, makes.

Embodiment 2 functional feed

Embodiments provide a kind of for preventing the functional feed of rainbow trout infectious pancreas infectious disease, in functional feed, the parts by weight of each raw material are: fish meal 9 weight portion, blood meal 3 weight portion, feather meal 6 weight portion, soya-bean cake 21 weight portion, shrimp chaff 11 weight portion, wheat flour 6 weight portion, rice bran 12 weight portion, grease 2 weight portion, Chinese scholartree leaf powder 6 weight portion, wheat bran 38 weight portion, salt 0.5 weight portion, vitamine supplement 1 weight portion, fodder yeast 1 weight portion, mineral additive 0.8 weight portion, trace mineral supplement 1 weight portion and Chinese medicine additive 8 weight portion, Chinese medicine additive wherein used is the Chinese medicine additive tablet of embodiment 1,

Its preparation method comprises the following steps:

The first step, pulverizes raw material stage: by described raw material: soya-bean cake, shrimp chaff, rice bran and wheat bran are pulverized, and grinding particle size is 300mm, makes its fine powder amount reach more than 92% of total material;

Second step, blend step: the raw material after the first step being pulverized and other raw materials add mixer, and mix, incorporation time is 60 minutes;

3rd step, granulation step: the mixture obtained by second step adds in granulator granulates, and pelleting temperature is set to 80 DEG C, and gelatinization degree reaches more than 93%;

4th step, drying steps: the feed granules that the 3rd step obtains is carried out drying, baking temperature is 55 DEG C, and drying time is 5 hours, and de-water ratio reaches more than 94%.

The toxicity test of Chinese medicine additive

1, trial drug: get coriandrum 15g, cape jasmine 20g, dayflower 18g, root of large-flowered skullcap 14g, coptis 16g, bark of ash 15g, kuh-seng 15g, Herba Andrographitis 18g, rhizome of cyrtomium 6g, cymose buckwheat rhizome 15g, sargentodoxa cuneata 15g, field pennycress 15g, Chinese lobelia 20g, brush-cherry seed 15g, lilac daphne 15g, Phytolacca acinosa 5g, pawpaw 15g, play both sides of the street 14g, caulis sinomenii 16g, heroubill 15g, Poria cocos 14g, rhizoma alismatis 15g, cucurbit 15g, hoveniae semoveniae semen 18g, shepherd's purse 25g, hirsute gonostegia herb with root 20g, bambusa textile ginseng 23g, tendrilleaf solomonseal rhizome 22g, China match justicia 23g, dillseed 24g, Han dish 20g, chicken crop 15g, Argemone mexicana 18g, purple casserole is put in whitebracteole bugle herb 22g mixing, add clear water, to clear water dipped medicinal material upper surface 3cm, soak 4 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to liquid be slowly 100ml, filters, obtain filtrate a, for subsequent use, the residue dregs of a decoction are added clear water again, to clear water dipped medicinal material upper surface 3cm, soaks 3 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25 minutes dosage to liquid be slowly 100ml, filters, obtain filtrate b, filtrate a and filtrate b is mixed to get decoction.

2, test method: select 30 healthy mices, female, each 15 of hero, is divided into test group and control group, each 15 at random.Take trial drug as object, test group 15 small white mouses are fed, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.2LD50,0.35LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 6000m part/k part BW (five dosage is 600,900,1200,2100,3000m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition test group, off-test, and by ascending-dose to tested material after 20 days, female, the buck of test group all occur without death condition.And compare with 15 small white mouses of control group, the equal Non Apparent Abnormalities of index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat.Can learn that Chinese medicine additive of the present invention does not have causing toxicity.

Contrast test

Rainbow trout cultivation base, Linqu County, Shandong Province, rainbow trout fry is about 3000 tails, in October, 2012,3 monthly ages at monthly age-4 rainbow trout outburst disease, dead nearly half.Sick fish body colour deepens, and abdominal distension, food refusal, occurs rotary motion before dying.Fish virus is isolated from sick fish guts with cell culture method.Standard anti-serum inspection through providing with the U.S., and compare with standard virus, confirm that this virus is for " infectious pancreatic necrosis virus (IP N V) " the sixth of the twelve Earthly Branches.The infectious disease that virus causes thus is called " fish infectious pancreatic necrosis (IPN).Can be judged as that ill is infectious pancreatic necrosis according to the above description.

Choose rainbow trout 160 tail of the same size, by 160 childhood rainbow trout pull out and be divided into three groups at random, often organize 80 tails, put into the container of the applicable rainbow trout growth relatively isolated respectively, environment of feeding is consistent.Be respectively test group and control group, the rainbow trout of two groups all without significant difference, has comparativity in body weight, the state of an illness etc.

Test group uses the functional feed of embodiments of the invention 2 to treat.Every day, feed continuously 7 days, every day more renewed water to the fish feeding in test group pond 1 time;

Control group uses rich going out 100 times to dilute rear full pool spilling head, and be used in conjunction two days, more renew water every day two days later, must health be mixed in conventional feed with the use of the frog, every day, to the fish feeding in control group pond 1 time, feeds 7 days continuously simultaneously;

The treatment situation of experimental session record rainbow trout childhood, the treatment front and back changes of weight situation of 15 days, and carry out meat nutrition judge to often organizing rainbow trout.Wherein, it is effective for treating situation: illness is removed; Invalid: the state of an illness is heavier or dead.Result is as shown in table 1, table 2, table 3.

Table 1 is the treatment situation contrast of each group:

Can be learnt by table 1, functional feed of the present invention is on treatment rainbow trout infectious pancreatic necrosis, and result for the treatment of is good, and cure rate is high, determined curative effect.

Table 2 is that each group for the treatment of daily weight of latter 15 days increases contrast:

Can be learnt by table 2, functional feed of the present invention is on treatment rainbow trout infectious pancreatic necrosis, and while treatment, the growth of rainbow trout, also comparatively faster than control group, effectively promotes its growth.

Table 3 is the trophic component contrast of the rainbow trout after the treatment of each group:

As can be seen from Table 3, DHA, the EPA of the rainbow trout after functional feed of the present invention treatment, moisture and crude protein equal size are all higher than the rainbow trout after treatment of control group, i.e. functional feed of the present invention, after treatment, nutritive value is higher.

In sum, functional feed of the present invention, on treatment rainbow trout infectious pancreatic necrosis, result for the treatment of is good, cure rate is high, determined curative effect, while treatment, better promote that it grows, moreover, there is no toxicity, also can better improve the nutritive value of rainbow trout in addition.

Model case: in April, 2013, one, Hebei province rainbow trout raiser, about 100 the monthly age at tail 3 monthly age-4 rainbow trout there is the symptom of infectious pancreatic necrosis, isolate ill rainbow trout, sick fish body colour deepens, abdominal distension, food refusal, can be judged as infectious pancreatic necrosis according to the above description.The functional feed of embodiments of the invention 2 is adopted to treat the ill rainbow trout of 100 tail.The functional feed of embodiment 2 is fed according to normal mode, feeds continuously 7 days.Feed after terminating, symptom all solutions removes, and weight average increases 0.31g.Later stage follows up, and sick fish is not recurred, and grows fine.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. one kind for preventing the functional feed of rainbow trout infectious pancreas infectious disease, it is characterized in that, described functional feed comprises following raw material: fish meal, blood meal, feather meal, soya-bean cake, shrimp chaff, wheat flour, rice bran, grease, Chinese scholartree leaf powder, wheat bran, salt, vitamine supplement, fodder yeast, mineral additive and trace mineral supplement.

2. according to claim 1 for preventing the functional feed of rainbow trout infectious pancreas infectious disease, it is characterized in that, in described functional feed, the ratio of weight and number of each raw material is: fish meal 9-13 weight portion, blood meal 2-5 weight portion, feather meal 6-8 weight portion, soya-bean cake 21-25 weight portion, shrimp chaff 11-15 weight portion, wheat flour 3-6 weight portion, rice bran 12-15 weight portion, grease 2-4 weight portion, Chinese scholartree leaf powder 6-8 weight portion, wheat bran 38-40 weight portion, salt 0.5-1 weight portion, vitamine supplement 0.5-1 weight portion, fodder yeast 1-2 weight portion, mineral additive 0.1-1 weight portion and trace mineral supplement 0.5-1 weight portion.

3. according to claim 1 and 2 for preventing the functional feed of rainbow trout infectious pancreas infectious disease, it is characterized in that, described functional feed also comprises Chinese medicine additive, in described functional feed, the ratio of weight and number of each raw material is: fish meal 9-13 weight portion, blood meal 2-5 weight portion, feather meal 6-8 weight portion, soya-bean cake 21-25 weight portion, shrimp chaff 11-15 weight portion, wheat flour 3-6 weight portion, rice bran 12-15 weight portion, grease 2-4 weight portion, Chinese scholartree leaf powder 6-8 weight portion, wheat bran 38-40 weight portion, salt 0.5-1 weight portion, vitamine supplement 0.5-1 weight portion, fodder yeast 1-2 weight portion, mineral additive 0.1-1 weight portion, trace mineral supplement 0.5-1 weight portion and Chinese medicine additive 5-8 weight portion.

4. the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-3, it is characterized in that, in described functional feed, the ratio of weight and number of each raw material is: fish meal 9 weight portion, blood meal 3 weight portion, feather meal 6 weight portion, soya-bean cake 21 weight portion, shrimp chaff 11 weight portion, wheat flour 6 weight portion, rice bran 12 weight portion, grease 2 weight portion, Chinese scholartree leaf powder 6 weight portion, wheat bran 38 weight portion, salt 0.5 weight portion, vitamine supplement 1 weight portion, fodder yeast 1 weight portion, mineral additive 0.8 weight portion, trace mineral supplement 1 weight portion and Chinese medicine additive 8 weight portion.

5. the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-4, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: coriandrum, cape jasmine, dayflower, the root of large-flowered skullcap, the coptis, the bark of ash, kuh-seng, Herba Andrographitis, rhizome of cyrtomium, cymose buckwheat rhizome, sargentodoxa cuneata, field pennycress, Chinese lobelia, brush-cherry seed, lilac daphne, Phytolacca acinosa, pawpaw, play both sides of the street, caulis sinomenii, heroubill, Poria cocos, rhizoma alismatis, cucurbit, hoveniae semoveniae semen, shepherd's purse, hirsute gonostegia herb with root, bambusa textile is joined, tendrilleaf solomonseal rhizome, China's match justicia, dillseed, Han dish, chicken crop, Argemone mexicana and whitebracteole bugle herb.

6. the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-5, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: coriandrum 10-25 weight portion, cape jasmine 12-20 weight portion, dayflower 10-28 weight portion, root of large-flowered skullcap 13-24 weight portion, coptis 12-20 weight portion, bark of ash 10-23 weight portion, kuh-seng 10-25 weight portion, Herba Andrographitis 12-28 weight portion, rhizome of cyrtomium 6-11 weight portion, cymose buckwheat rhizome 15-25 weight portion, sargentodoxa cuneata 13-20 weight portion, field pennycress 10-25 weight portion, Chinese lobelia 10-20 weight portion, brush-cherry seed 12-25 weight portion, lilac daphne 15-24 weight portion, Phytolacca acinosa 5-12 weight portion, pawpaw 11-20 weight portion, play both sides of the street 10-20 weight portion, caulis sinomenii 14-26 weight portion, heroubill 10-25 weight portion, Poria cocos 11-24 weight portion, rhizoma alismatis 10-20 weight portion, cucurbit 10-25 weight portion, hoveniae semoveniae semen 12-28 weight portion, shepherd's purse 13-25 weight portion, hirsute gonostegia herb with root 10-20 weight portion, bambusa textile ginseng 13-30 weight portion, tendrilleaf solomonseal rhizome 15-28 weight portion, China match justicia 10-25 weight portion, dillseed 12-24 weight portion, Han dish 10-20 weight portion, chicken crop 15-25 weight portion, Argemone mexicana 14-22 weight portion, whitebracteole bugle herb 12-30 weight portion.

7. the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-6, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: coriandrum 15 weight portion, cape jasmine 20 weight portion, dayflower 18 weight portion, the root of large-flowered skullcap 14 weight portion, the coptis 16 weight portion, the bark of ash 15 weight portion, kuh-seng 15 weight portion, Herba Andrographitis 18 weight portion, rhizome of cyrtomium 6 weight portion, cymose buckwheat rhizome 15 weight portion, sargentodoxa cuneata 15 weight portion, field pennycress 15 weight portion, Chinese lobelia 20 weight portion, brush-cherry seed 15 weight portion, lilac daphne 15 weight portion, Phytolacca acinosa 5 weight portion, pawpaw 15 weight portion, play both sides of the street 14 weight portions, caulis sinomenii 16 weight portion, heroubill 15 weight portion, Poria cocos 14 weight portion, rhizoma alismatis 15 weight portion, cucurbit 15 weight portion, hoveniae semoveniae semen 18 weight portion, shepherd's purse 25 weight portion, hirsute gonostegia herb with root 20 weight portion, 23 weight portions joined by bambusa textile, tendrilleaf solomonseal rhizome 22 weight portion, China's match justicia 23 weight portion, dillseed 24 weight portion, Han dish 20 weight portion, chicken crop 15 weight portion, Argemone mexicana 18 weight portion, whitebracteole bugle herb 22 weight portion.

8. the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-7, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 84 ~ 92%, adds hot reflux 2 ~ 4 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 84 ~ 92%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 200 order ~ 300 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline cellulose of its quality 0.2 ~ 0.4 times, 0.05 ~ 0.12 times of lactose, the starch of 0.1 ~ 0.4 times, sieve, mix, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.03 times of dolomol, whole grain, compressing tablet, makes.

9. the preparation method of the functional feed for preventing rainbow trout infectious pancreas infectious disease according to any one of claim 1-8, it is characterized in that, described preparation method comprises the following steps:

The first step, pulverizes raw material stage: by described raw material: soya-bean cake, shrimp chaff, rice bran and wheat bran are pulverized, and grinding particle size is 300 ~ 550mm, makes its fine powder amount reach more than 92% of total material;

Second step, blend step: the raw material after the first step being pulverized and other raw materials add mixer, and mix, incorporation time is 40-60 minute;

3rd step, granulation step: the mixture obtained by second step adds in granulator granulates, and pelleting temperature is set to 70-80 DEG C, and gelatinization degree reaches more than 93%;

4th step, drying steps: the feed granules that the 3rd step obtains is carried out drying, baking temperature is 50-65 DEG C, and drying time is 4-8 hour, and de-water ratio reaches more than 94%.