CN101869220A - Traditional herbal medicine feed addictive for preventing and controlling swine high fever syndrome - Google Patents

Abstract

The invention discloses a traditional herbal medicine feed addictive for preventing and controlling swine high fever syndrome, belonging to the technical field of feed addictives. The addictive is prepared from Chinese angelica, white paeony root, scutellaria, argy wormwood leaf, rhizoma atractylodis, hawthorn, magnolia officinalis, dried orange peel and liquorice as raw materials according to a certain weight part. By using the functions of enhancing the immunity of pigs, improving the success rate of vaccination and the like, the traditional herbal medicine feed addictive achieves the aims of improving the growth speed of commercial pigs and the conversion rate of the feed, reducing the death rate and the mortality of the pigs and improving economic benefits. The traditional herbal medicine feed addictive can be popularized and applied in pig farmers or farms.

Description

Chinese herbal medicine feed additive for preventing and controlling swine high fever syndrome

Technical Field

The invention relates to the technical field of feed additives, in particular to a Chinese herbal medicine feed additive with prevention and control effects on swine high fever syndrome and a preparation method thereof.

Background

Porcine hyperthermia syndrome is an infectious disease whose cause is not finally determined, and clinically, sick pigs show high body temperature rise, red skin, respiratory symptoms and digestive symptoms, and high morbidity and mortality. The swinery dies 5-7 days after the disease occurs, and the death gradually subsides after 3 weeks. The incidence rate of the diseases of the swinery is 50-100 percent, and the fatality rate of the diseases is 20-100 percent. In 2006, the swine fever syndrome which occurs in southern provinces at first in China and gradually spreads and spreads to most of swine provinces and regions in China causes huge loss to the swine industry in China, the quantity of stocked swine in some regions with serious epidemic situations is reduced by more than 60%, a plurality of medium and small-sized swine farms are closed due to the high fever syndrome, and the prevalence of the epidemic disease causes death of diseases and culled pigs to reach tens of millions according to estimation of related persons in the industry.

The etiology of porcine high fever syndrome has not been determined to date. From the pathogens detected and separated from sick and dead pigs, porcine reproductive and respiratory syndrome (blue ear disease) virus, porcine circovirus type 2, hog cholera virus, swine influenza virus, porcine pseudorabies virus, escherichia coli, streptococcus suis type 2, salmonella, pasteurella multocida, actinobacillus pleuropneumoniae, haemophilus parasuis, staphylococcus, treponema, toxoplasma gondii, eperythrozoon and the like are involved, and the pathogens are considered to be caused by mixed infection of different combinations of variant strains, bacteria and protozoa of the viruses or the viruses; there is also an epidemiological factor analysis based on which it is believed that an unknown pathogen (virus) is truly an alleged cause.

Because the etiology is unknown, no specific prevention and treatment measures for the swine high fever syndrome exist at present. The method has the main tasks of cutting off all possible spreading sources for a pig farm without epidemic situation, well performing immunization of epidemic diseases such as swine fever and swine enzootic pneumonia, strengthening the feeding management of pigs, increasing the feeding of nutrient additives capable of enhancing the resistance of swinery and well performing the drug prevention and health care of the swinery; for a pig farm with epidemic situation, measures such as disinfection, closing of a pig house with the disease, restriction of flow of raising personnel and the like are enhanced to prevent the spread of the epidemic situation, timely isolation and independent treatment of the sick pigs are needed, and harmless treatment such as deep burying or burning of the pigs dead of the disease is needed to prevent the spread of the pathogen. The vaccine immunization is stopped for the sick pig herd, the antipyretic or antibacterial drug is not needed in the early stage, and the death of the sick pig is accelerated by indiscriminate drug administration. The maintenance measures such as electrolyte and multiple vitamins can be added into drinking water, and after 5-7 days, some symptomatic treatments and antibiotics can be added to control secondary infection.

Through tests, the Chinese herbal medicine feed additive added into the pig feed has a good prevention and control effect on the high fever syndrome of pigs, can reduce the death rate of the herd with epidemic disease by 15 percent (65.2 percent), can improve the growth speed and the feed conversion efficiency of the pigs, and improves the economic benefit.

Disclosure of Invention

Aiming at the pig high fever syndrome, no specific effective prevention and control method exists at present, and a Chinese herbal medicine feed additive with prevention and control effects on the pig high fever syndrome is provided through a compatibility test of compound Chinese herbal medicines, so that various medicines are mutually cooperated to play roles in improving the immunity of the organism, inhibiting or killing probably related pathogeny, and relieving or eliminating various symptoms caused by the high fever syndrome so as to achieve the effect of preventing and controlling the pig high fever syndrome; the invention also aims to provide a preparation method of the Chinese herbal medicine feed additive.

The Chinese herbal medicine feed additive selects Chinese angelica, white paeony root, baical skullcap root, Chinese mugwort leaf, swordlike atractylodes rhizome, hawthorn fruit, officinal magnolia bark, tangerine peel, liquoric root, pilose asiabell root, medicated leaven, Indian buead, sweet wormwood herb, lightyellow sophora root and Chinese pulsatilla root as raw medicinal materials, and is characterized in that:

angelica sinensis can tonify blood, regulate menstruation, promote blood circulation, relieve pain, moisten intestines and relieve constipation. Has effects in nourishing blood, promoting granulation, expelling pus, supporting the interior, moistening intestine and stomach, caring skin, and tonifying blood. Radix Angelicae sinensis contains volatile oil (main component of ligustilide), alkaloid, ferulic acid, radix Angelicae sinensis polysaccharide, fatty oil, nicotinic acid, sucrose, and vitamin B₁₂And trace elements. The angelica can promote the generation of hemoglobin and red blood cells and has the functions of anti-anemia and hematopoiesis; the angelica and the sodium ferulate can inhibit platelet aggregation and have obvious antithrombotic effect, and the angelica has the functions of expanding blood vessels, resisting myocardial ischemia and reducing blood fat. The angelica can also obviously improve the phagocytic capacity of monocytes and abdominal macrophages. Can relax smooth muscle of trachea and has strong spasmolytic effect. Has obvious protective effect on liver damage, liver cell membrane damage and liver mitochondria damage caused by carbon tetrachloride and D-galactosamine, and also has obvious promoting effect on bile secretion. In vitro tests show that radix Angelicae sinensis has inhibitory effect on dysentery bacillus, typhoid bacillus, Escherichia coli, hemolytic streptococcus, etc.

White peony root, radix Paeoniae alba nourishes blood and astringes yin, regulates ying and wei, purges liver and calms spleen. Can be used for treating chest and hypochondrium pain, damp-heat dysentery, and tenesmus abdominal pain. Radix Paeoniae alba contains paeoniflorin, benzoic acid, tannin, volatile oil and paeoniflorin. Has strong inhibiting effect on dysentery bacillus, Escherichia coli, Pseudomonas aeruginosa, staphylococcus, hemolytic streptococcus, Diplococcus pneumoniae, etc. Radix Paeoniae alba also has analgesic and anticonvulsant effects, and can improve tolerance of animal to high temperature stimulation. In addition, the phagocytic function of reticuloendothelial system and the phagocytic function of abdominal macrophage are obviously enhanced; can restore the antibody production of cyclophosphamide-induced hypoimmunity mice to normal level. The white peony root has obvious anti-inflammatory effect, has an inhibiting effect on smooth muscle contraction, has a spasmolytic effect on bronchial smooth muscle spasm during animal asthma attack, and also has an antitussive effect due to bronchiectasis.

Huang Qin clears heat and dries dampness, purges fire and relieves toxicity, especially for clearing lung heat, it is commonly used for cough and dyspnea due to lung heat. Contains baicalin, baicalein, wogonin, and baicalein. Has broad-spectrum antibacterial effect, and can inhibit typhoid bacillus, dysentery bacillus, Pseudomonas aeruginosa, tubercle bacillus, Bordetella pertussis, Vibrio cholerae, staphylococcus, hemolytic streptococcus, meningococcus, influenza virus, dermatophytes, etc. Has antipyretic, tranquilizing, blood pressure lowering, diuretic, animal allergic asthma and skin allergy inhibiting, and capillary permeability reducing effects. Can reduce the lung injury of mice infected with influenza virus and prolong the survival time. Baicalein has antiallergic effect by inhibiting the release of allergic mediator (histamine, chronic reaction substance SRS-A) by inhibiting the prevalence of mercaptoenzyme, and has direct relaxation effect on smooth muscle. It can be used for treating influenza, hyperpyrexia, anicteric hepatitis, pyelonephritis, and viral pneumonia.

Folium Artemisiae Argyi contains volatile oils such as phellandrene, piperylene, thujaplicin, thujaponin, stigmasterol, beta-sitosterol, alpha-resinol, tannin, potassium chloride, vitamin A, D, B, C and choline. The water decoction has different degrees of inhibition effects on staphylococcus aureus, alpha-hemolytic streptococcus, pneumococcus, diphtheria bacillus, dysentery bacillus, typhoid bacillus, paratyphoid bacillus, vibrio cholerae and the like in vitro tests, and has a certain inhibition effect on fungi. The water extract has effects of relaxing guinea pig bronchus, promoting blood coagulation and relieving fever, and promoting urination. It also has therapeutic effect on chronic hepatitis and protozoosis.

Rhizoma atractylodis has the functions of drying dampness and strengthening spleen, and dispelling wind and eliminating dampness and is used for treating abdominal distension, diarrhea and inappetence caused by transport and transformation disorder, can relieve pathogenic wind-cold and can transform damp-turbidity into stagnation, and is the essential product for treating abnormal qi in four seasons. Rhizoma Atractylodis contains volatile oil such as atractylol, atractyl, beta-eucalyptol, etc., and also contains small amount of atractylone and large amount of vitamins A, D and B. It can be used for treating incoordination between spleen and stomach, diarrhea, damp-heat syndrome, dysentery, etc.

Haw is effective in promoting digestion, resolving food stagnation, promoting blood circulation, removing blood stasis, and relieving diarrhea and dysentery. Contains maslinic acid, tartaric acid, citric acid, flavonoids, lactone, saccharides, glycosides, lipolytic enzyme, vitamin C, protein, etc. Has inhibitory effect on various dysentery bacillus and Pseudomonas aeruginosa, and has effects of dilating coronary artery, enhancing myocardial contraction force, slowing heart rate, improving myocardial blood circulation, lowering blood pressure, promoting gastric juice digestive enzyme secretion, and promoting digestion.

The magnolia bark has the functions of promoting qi circulation, eliminating dampness, lowering adverse qi and relieving asthma. It is suitable for treating abdominal distention and abdominal pain due to qi movement disorder, abdominal distention and abdominal pain due to heat accumulation constipation, phlegm retention, cough and asthma. Contains Magnolia officinalis oil, beta-eucalyptol, magnolol, Magnolia obuxonine, tannin, nicotinic acid, etc. Has good inhibitory effect on dysentery bacillus, staphylococcus, amebic protozoa, etc. It is also useful for treating hepatitis B.

Tangerine peel, pericarpium Citri Reticulatae promotes the circulation of qi and strengthens the spleen, eliminates dampness and phlegm. Mainly treats the diseases such as discomfort of spleen and stomach, vomiting, cough, fullness and inappetence, vertigo and the like, contains hesperetin and cis-coumarine, has anti-inflammatory effect, and has obvious anti-ulcer effect on methyl hesperidin. The in vitro test has the effects of inhibiting the growth of staphylococcus, Katanil bacteria and haemophilus hemolyticus. Also contains a large amount of vitamin B₁。

Licorice root, radix Glycyrrhizae has the effects of invigorating the middle warmer, replenishing qi, clearing away heat and toxic materials, moistening lung, arresting cough, relieving spasm, alleviating pain, and regulating drug properties. Can be used for treating spleen deficiency, qi deficiency, blood deficiency, heat toxin attacking throat swelling and pain, cough due to lung heat, cough due to lung cold, bladder retention, micturition pain, abdominal spasm pain, stomach cold, abdominal pain, and diarrhea. The Glycyrrhrizae radix contains glycyrrhizin, liquiritin and adrenocorticoid. Has good curative effect on various toxicosis, metabolite poisoning in vivo, tetanus endotoxin, allergic diseases and the like. Has effects in inhibiting smooth muscle activity and relieving intestinal spasm; inhibiting gastric acid secretion, eliminating phlegm, and relieving pain.

Codonopsis pilosula has the effects of tonifying middle-jiao and Qi, enriching blood and promoting fluid production. It is an important herb for deficiency of both qi and blood because it excels in regulating the spleen and stomach. Radix Codonopsis contains saponin, alkaloid, protein, and vitamin B₁And B₂And glucose and the like. Radix Codonopsis has effects of exciting nervous system, enhancing body resistance, increasing erythrocyte and hemoglobin, and can be used for treating iron deficiency anemia and malnutritional anemia, especially anemia due to digestive absorption dysfunction. The external medicine can eliminate phlegm, invigorate stomach and strengthen metabolism; helping digestion and promoting chyle absorption; increasing blood sugar and promoting blood coagulation. When being matched with angelica, the composition can supplement qi and blood, and further enhance the defense capability of the organism. The codonopsis pilosula stimulates the nervous system to resist the mental depression of the sick pigs;

medicated leaven has the effects of promoting digestion and invigorating stomach, and can be used for treating dyspepsia due to food damage and exogenous pathogenic factors, and diarrhea due to spleen deficiency. The medicated leaven contains lactic acid bacteria, yeast, amylase, volatile oil, glycosides, vitamin B, etc., and has the function of helping digestion of protein, fat and starch.

Poria contains beta-pachyman, triterpenes, ergosterol, protein, fat, lecithin, choline, potassium salt, etc. The ethanol extract of Poria can kill leptospira in vitro. It is combined with Dang Gui and Bai Shao to treat recessive HBV carriers. Therefore, the compound can be used for treating other viral diseases when being matched with the prescription.

Herba Artemisiae Annuae has effects of clearing away heat, relieving summer-heat, cooling blood, removing heat from the blood, and clearing deficiency heat, and contains artemisinin with effects of resisting plasmodium, coccidium, eperythrozoon, toxoplasma, etc., and its alcohol extract has effect of inhibiting leptospira.

Flavescent sophora root has the functions of clearing away heat, drying dampness, dispelling wind, killing parasites and promoting urination. Has inhibiting effect on Staphylococcus aureus, Pseudomonas aeruginosa, dermatophytes, trichomonad, coccidium, etc., and has obvious effect on piglet dysentery.

The Chinese pulsatilla root has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery, has the effects of inhibiting and killing coccidium, trichomonad, amoeba and other protozoa, and has the treatment effects on bacillary dysentery, mycotic enteritis, ulcerative colitis and the like.

The pathogenesis process of the high fever syndrome is as follows: generally, pigs in the early stage of disease only show increased body temperature, depressed spirit, decreased food intake or loss of appetite, then most pigs are constipation and are spherical, a small amount of sick pigs have diarrhea, yellow and little urine, turbidity and deepened color. The skin of pig is red, the ear edge is cyanosed after the ear, and skin of many parts of the body such as the abdomen and the extremities has purplish red plaques, and the viscera are dissected to show typical septicemia changes. The pigs suffering from dyspnea and lying are partially suffered from severe abdominal respiration and asthma, some pigs are irregularly breathed, and the pigs suffering from rhinorrhea, sneezing, cough and eye secretion increase are suffered from conjunctivitis symptoms. The sick pigs are rapidly thinned, the pigs with a long disease course are pale, the anemia phenomenon appears, the fur is rough, some pigs are yellow-dyed, individual pigs cannot stand before death, and finally the whole pigs die due to convulsion.

The Chinese herbal medicine components of the additive are designed aiming at the clinical symptoms of the swine high fever syndrome: wherein,

radix Codonopsis, radix Angelicae sinensis, radix Paeoniae alba, and Poria all have functions of enhancing immunity and resistance. Particularly, at present, pig farms are originally infected with immune system suppression diseases such as blue-ear diseases, circovirus, swine fever and the like, the overall immune level of the swinery to various infectious diseases is not high, and hidden troubles are buried for outbreak of high fever syndrome. Therefore, improving the resistance of pigs is one of the key measures for preventing such diseases. Scutellariae radix, folium Artemisiae Argyi, and cortex Magnolia officinalis can be used for treating viral diseases such as influenza, hepatitis, and pneumonia, and can also inhibit related viruses. The scutellaria baicalensis, the white paeony root, the folium artemisiae argyi, the hawthorn, the angelica, the dried orange peel and the like have the effect of inhibiting or killing most of gram-positive bacteria and gram-negative bacteria separated from pigs suffering from high fever syndrome. Cortex Magnolia officinalis and folium Artemisiae Argyi have effects of preventing and controlling protozoal diseases. The scutellaria baicalensis clears heat and dampness, purges fire and detoxifies, particularly clears lung heat and treats asthma and cough, and is the symptomatic medicine for treating high fever; the Chinese medicinal composition is also used for treating symptoms of throat swelling and pain, lung heat cough and the like due to congestion or hemorrhage of the larynx and trachea of the pig suffering from high fever and hemorrhagic lung and interstitial pneumonia of the lung. Rhizoma Atractylodis, fructus crataegi, Massa Medicata Fermentata, cortex Magnolia officinalis, pericarpium Citri Tangerinae, and radix Codonopsis can be used for treating anorexia, constipation, and diarrhea and enhancing gastrointestinal digestion function; the folium artemisiae argyi has the effect of treating dysuria, and Chinese herbal medicines such as the angelica sinensis, the folium artemisiae argyi, the rhizoma atractylodis, the hawthorn, the mangnolia officinalis and the like can provide a large amount of vitamins and trace elements to ensure normal operation of body metabolism; the liquorice can neutralize endotoxin generated in metabolism, and can prevent accumulation and poisoning of the endotoxin in sick pigs and death due to the normal digestion, absorption and excretion functions of the sick pigs. In order to enhance the control of parasitic diseases such as pig eperythrozoon, toxoplasma, coccidium and the like, the invention can also add sweet wormwood, radix sophorae flavescentis and Chinese pulsatilla root on the basis of the medicinal materials.

The raw medicinal materials of the invention achieve the comprehensive effect of preventing and controlling the porcine hyperthermia syndrome by the dual functions of inhibiting or killing pathogenic microorganisms and treating various diseases appearing in the porcine hyperthermia syndrome.

The purpose of the invention is realized by the following technical scheme.

The Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of pigs comprises the following raw material medicines in parts by weight: 2-8 parts of angelica sinensis, 2-5 parts of radix paeoniae alba, 8-12 parts of scutellaria baicalensis, 4-6 parts of folium artemisiae argyi, 5-8 parts of rhizoma atractylodis, 8-12 parts of hawthorn, 2-5 parts of mangnolia officinalis, 5-8 parts of pericarpium citri reticulatae and 4-6 parts of liquorice.

The preferred formulation of the additive is: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae and 5 parts of liquorice.

The Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of pigs comprises the following raw material medicines: 2-5 parts of codonopsis pilosula, 8-12 parts of medicated leaven and 3-7 parts of poria cocos.

The preferred formulation of the additive is: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae, 5 parts of liquorice, 3 parts of codonopsis pilosula, 10 parts of medicated leaven and 5 parts of poria cocos.

The Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of pigs comprises the following raw material medicines: 3-7 parts of sweet wormwood, 3-8 parts of radix sophorae flavescentis and 3-8 parts of Chinese pulsatilla root.

The preferred formulation of the additive is: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae, 5 parts of liquorice, 3 parts of codonopsis pilosula, 10 parts of medicated leaven, 5 parts of poria cocos, 5 parts of sweet wormwood, 5 parts of radix sophorae flavescentis and 5 parts of Chinese pulsatilla root.

The preparation method of the Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of the pigs comprises the following steps:

(1) drying and crushing the raw material medicines: drying the raw materials in the sun or in an oven at 60 deg.C; weighing each dry raw material medicine according to a formula; pulverizing the dried raw materials except fructus crataegi and folium Artemisiae Argyi with pulverizer respectively, sieving with 60 mesh sieve, and mixing;

(2) and (3) processing the hawthorn: pulverizing dried fructus crataegi with pulverizer, sieving with 60 mesh sieve, removing hard shell on the sieve, and retaining powder under the sieve;

(3) processing the folium artemisiae argyi: pulverizing dried folium Artemisiae Argyi with pulverizer, and sieving with 60 mesh sieve; decocting the screened large-volume floccules twice with water, wherein the water amount is preferably larger than the medicine surface each time, soaking for 6 hours for the first time, heating and decocting for 30 minutes, and soaking for 2 hours for the second time, and decocting for 30 minutes; cooling each time, squeezing and filtering with 200 mesh nylon screen cloth, mixing extractive solutions, and heating and concentrating to one tenth of original volume; pouring the concentrated solution into sieved folium Artemisiae Argyi powder, stirring, oven drying at 60 deg.C, cooling, and pulverizing into powder;

(4) mixing of the additive: and (3) adding the hawthorn powder in the step (2) and the folium artemisiae argyi powder in the step (3) into the mixed powder in the step (1), and uniformly mixing to obtain the Chinese herbal medicine feed additive.

The application method of the Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of the pigs comprises the following steps: adding the feed in an amount of 0.35%, 0.30% and 0.25% of the weight of the feed respectively in the piglet stage, the pig growth stage and the pig fattening stage, and feeding after uniformly stirring.

The invention has the beneficial effects that:

1. currently, most people consider porcine hyperthermia syndrome to be caused by a mixed infection of viruses, bacteria and protozoa. The feed additive contains broad-spectrum antiviral, antibacterial and antiprotozoal Chinese herbal medicine effective components, and can be used for treating various mixed infection sources of swine high fever syndrome.

2. The feed additive contains a plurality of raw material medicines for enhancing the immunity and the resistance of organisms, can resist the inhibition of an immune system caused by certain viral diseases, reduces secondary infection and improves the survival rate of sick pigs.

3. The feed additive contains the medicines for improving the appetite of animals, promoting digestion and absorption, facilitating excretion and preventing endotoxin poisoning; wherein, the normal appetite and the digestion and absorption functions are maintained, so that the animals can be ensured to take enough nutrition and medicines every day, and the prevention and treatment effects of the medicines are exerted; the normal excretion function is maintained, and the food residues and metabolites can be prevented from being fermented by harmful microorganisms in vivo to generate endotoxin to cause septicemia; the medicine capable of neutralizing endotoxin poisoning has the insurance effect of further eliminating endotoxin.

4. The feed additive contains the medicines for clearing heat, purging fire, detoxifying and treating lung heat cough and asthma, and can be used for resisting the symptoms of body temperature rise, pneumonia and cough and asthma caused by the swine high fever syndrome.

5. The feed additive disclosed by the invention is composed of multiple Chinese herbal medicines rich in vitamins and minerals, and can maintain normal physiological functions, reduce death and accelerate recovery of animals under the condition that electrolytes such as diarrhea and vomiting of pigs are greatly lost.

6. Because the folium artemisiae argyi is large in size after being crushed, the folium artemisiae argyi is difficult to be uniformly mixed with the powder of other raw material medicines, and the palatability is poor, the large-size flocculent oversize product of the crushed folium artemisiae argyi is mixed with other raw materials after the effective components of the crushed folium artemisiae argyi are extracted by water, so that the palatability is improved, the volume of the feed additive is greatly reduced, and the condition that a pig can take enough nutrition and medicines to play the physiological functions of the pig can be ensured.

7. After the Chinese herbal medicine feed additive is used, antibiotics do not need to be added into the feed, so that green and safe pork without the antibiotics can be produced, the drug resistance of microorganisms to the antibiotics can be relieved, the service life of the antibiotics is prolonged, the development cost is reduced, and the prevention and treatment cost of high fever is favorably reduced.

8. After the Chinese herbal medicine feed additive is used, when a pig farm suffers from high fever syndrome of pigs, the Chinese herbal medicine feed additive has the effects of preventing and controlling the disease, can improve the growth speed and the feed conversion efficiency of the pigs, reduce the death rate and the elimination rate of the pigs, reduce the loss caused by diseases and improve the economic benefit of pig raising (see test example 3).

Detailed Description

The Chinese herbal medicine feed additive with prevention and control effect on swine high fever syndrome and the preparation method thereof are further described in detail by the following examples.

Example 1: (Chinese herbal medicine feed additive formula 1)

The formula of the additive comprises the following components: 2kg of angelica, 5kg of white paeony root, 8kg of scutellaria baicalensis, 6kg of folium artemisiae argyi, 5kg of rhizoma atractylodis, 12kg of hawthorn, 2kg of mangnolia officinalis, 8kg of dried orange peel and 4kg of liquorice.

Example 2: (Chinese herbal medicine feed additive formula 2)

The formula of the additive comprises the following components: 5kg of angelica, 3kg of white paeony root, 10kg of scutellaria baicalensis, 5kg of folium artemisiae argyi, 7kg of rhizoma atractylodis, 10kg of hawthorn, 3kg of mangnolia officinalis, 7kg of dried orange peel and 5kg of liquorice.

Example 3: (Chinese herbal medicine feed additive formula 3)

The formula of the additive comprises the following components: 8kg of angelica, 2kg of white paeony root, 12kg of scutellaria baicalensis, 4kg of folium artemisiae argyi, 8kg of rhizoma atractylodis, 8kg of hawthorn, 5kg of mangnolia officinalis, 5kg of dried orange peel and 6kg of liquorice.

Example 4: (Chinese herbal medicine feed additive formula 4)

The formula of the additive is as follows: 8kg of angelica, 2kg of white paeony root, 12kg of baical skullcap root, 4kg of argyi leaf, 8kg of swordlike atractylodes rhizome, 8kg of hawthorn fruit, 5kg of officinal magnolia bark, 5kg of tangerine peel, 6kg of liquoric root, 2kg of pilose asiabell root, 12kg of medicated leaven and 3kg of Indian buead.

Example 5: (Chinese herbal medicine feed additive formula 5)

The formula of the additive is as follows: 5kg of angelica, 3kg of white paeony root, 10kg of baical skullcap root, 5kg of argyi leaf, 7kg of swordlike atractylodes rhizome, 10kg of hawthorn fruit, 3kg of officinal magnolia bark, 7kg of tangerine peel, 5kg of liquoric root, 3kg of pilose asiabell root, 10kg of medicated leaven and 5kg of Indian buead.

Example 6: (Chinese herbal medicine feed additive formula 6)

The formula of the additive is as follows: 2kg of angelica, 5kg of white paeony root, 8kg of scutellaria baicalensis, 6kg of folium artemisiae argyi, 5kg of rhizoma atractylodis, 12kg of hawthorn, 2kg of mangnolia officinalis, 8kg of dried orange peel, 4kg of liquorice, 5kg of codonopsis pilosula, 8kg of medicated leaven and 7kg of poria cocos.

Example 7: (Chinese herbal medicine feed additive formula 7)

The formula of the additive is as follows: 2kg of Chinese angelica, 5kg of white paeony root, 8kg of baical skullcap root, 6kg of Chinese mugwort leaf, 5kg of swordlike atractylodes rhizome, 12kg of hawthorn, 2kg of officinal magnolia bark, 8kg of tangerine peel, 4kg of liquoric root, 5kg of pilose asiabell root, 8kg of medicated leaven, 7kg of Indian buead, 3kg of sweet wormwood herb, 8kg of lightyellow sophora root and 3kg of Chinese pulsatilla root.

Example 8: (Chinese herbal medicine feed additive formula 8)

The formula of the additive is as follows: 5kg of Chinese angelica, 3kg of white paeony root, 10kg of baical skullcap root, 5kg of Chinese mugwort leaf, 7kg of swordlike atractylodes rhizome, 10kg of hawthorn fruit, 3kg of officinal magnolia bark, 7kg of tangerine peel, 5kg of liquoric root, 3kg of pilose asiabell root, 10kg of medicated leaven, 5kg of Indian buead, 5kg of sweet wormwood herb, 5kg of lightyellow sophora root and 5kg of Chinese pulsatilla root.

Example 9: (Chinese herbal medicine feed additive formula 9)

The formula of the additive is as follows: 8kg of Chinese angelica, 2kg of white paeony root, 12kg of baical skullcap root, 4kg of Chinese mugwort leaf, 8kg of swordlike atractylodes rhizome, 8kg of hawthorn fruit, 5kg of officinal magnolia bark, 5kg of tangerine peel, 6kg of liquoric root, 2kg of pilose asiabell root, 12kg of medicated leaven, 3kg of Indian buead, 7kg of sweet wormwood herb, 3kg of lightyellow sophora root and 8kg of Chinese pulsatilla root.

Example 10: (method for preparing additive of examples 1, 2, 3, 4, 5, 6, 7, 8 or 9)

The method comprises the following steps:

(1) drying and crushing the raw material medicines: baking the raw materials in a 60 ℃ oven for 4 hours respectively until the raw materials are dried; weighing the dry raw materials according to the formula; pulverizing the dried raw materials except folium Artemisiae Argyi and fructus crataegi respectively with a pulverizer, sieving with 60 mesh sieve, and mixing;

(2) and (3) processing the hawthorn: pulverizing dried fructus crataegi with pulverizer, sieving with 60 mesh sieve, removing hard shell on the sieve, and retaining powder under the sieve;

(3) processing the folium artemisiae argyi: pulverizing dried folium Artemisiae Argyi with pulverizer, and sieving with 60 mesh sieve; decocting the screened large-volume floccules twice with water, wherein the water amount is preferably larger than the medicine surface each time, soaking for 6 hours for the first time, heating and decocting for 30 minutes, and soaking for 2 hours for the second time, and decocting for 30 minutes; cooling each time, squeezing and filtering with 200 mesh nylon screen cloth, mixing extractive solutions, and heating and concentrating to one tenth of original volume; pouring the concentrated solution into sieved folium Artemisiae Argyi powder, stirring, oven drying at 60 deg.C, cooling, and pulverizing into powder;

(4) mixing of the additive: and (3) adding the hawthorn powder in the step (2) and the folium artemisiae argyi powder in the step (3) into the mixed powder in the step (1), and uniformly mixing in a mixer to obtain the Chinese herbal medicine feed additive.

Test example 1: (comparative tests of different feed additives on pig growth and feed conversion rates)

40 weaned piglets with the weight of about 10kg are selected, the number of the weaned piglets is 4 for each half of the weaned piglets and 2 for each group. The control group was fed with antibiotics and the test group was fed with the Chinese herbal medicine feed additive and the compound feed according to the formula of example 2 at a ratio of 0.35% (no antibiotics were added to the feed). As a result: the daily gain of the piglet stage test group and the piglet stage control group are 433 +/-173 g and 371 +/-154 g respectively, the feed weight ratio is 2.00 and 2.31 respectively, the daily gain of the test group is increased by 16.7 percent compared with the piglet stage control group, and the feed weight ratio is reduced by 13.4 percent; the daily gain of the test group and the control group in the growing pig stage is 548 +/-71 g and 474 +/-87 g respectively, the feed-weight ratio is 2.50 and 2.82 respectively, the daily gain of the test group is increased by 15.6 percent compared with the control group, and the feed-weight ratio is reduced by 11.3 percent. Tests prove that the Chinese herbal medicine feed additive has better growth promoting effect and feed reward improving effect by replacing antibiotics.

Test example 2: (comparative tests of different feed additives on pig mortality, elimination rate, feed-to-weight ratio and digestibility)

400 weaned piglets weighing about 14kg were picked and randomly divided into 4 groups of 10 columns with 10 pigs in each group and pigs in 4 groups randomly distributed in 2 piggeries. Feeding antibiotic + compound feed (the antibiotic used in the feed in the piglet stage is sulfuric acid antibiotics + bacitracin zinc + p-aminobenzene arsenic acid, and the antibiotic used in the growing pig and fattening pig stage is aureomycin + p-aminobenzene arsenic acid); group 2 was fed with the herbal feed additive + compound feed (0.35% in piglet stage feed and 0.30% in growing pig stage feed) of the formula of example 2; feeding the group 3 with the feed additive containing the Chinese herbal medicines prepared in example 3 in the same amount as the group 2; group 4 was fed the same feed supplement containing the herbal composition prepared in example 4 in the same amount as in group 2. The basic formulas of the daily rations of 4 groups are the same, 3 groups using the Chinese herbal medicine feed additive do not contain any antibiotic, and other daily production management is the same as that of a pig farm production group.

Approximately 1 month after the start of the trial, the pig farm was attacked by swine high fever syndrome, and the trial house was also infected. As a result, 23 pigs in group 1, the antibiotic control group, died with a mortality rate of 23%; group 2, group 3 and group 4 died 9, 8, 9 respectively, with mortality rates of 9%, 8% and 9%, respectively. The two percentage data were tested for significant difference, with group 2 and group 4 being significantly different from the control (P < 0.05), and group 3 being significantly different from the control (P < 0.01). The application of the Chinese herbal medicine feed additive of the invention can obviously reduce the death rate of the swinery affected by the hyperpyrexia syndrome. Some pigs suffering from high fever syndrome are eliminated as dead pigs without death through rescue and treatment, and the eliminated pigs of the 1 st group to the 4 th group have 11 heads, 4 heads, 2 heads and 3 heads respectively. Through statistical test, the elimination rate of the group 3 and the group 4 is obviously lower than that of the control group (P is less than 0.05), and the difference between the group 2 and the control group is not obvious (P is more than 0.05). If the Chinese herbal medicine feed additives are combined and calculated, the elimination rate of the Chinese herbal medicine feed additive group is extremely lower than that of an antibiotic control group (P is less than 0.01), so the number of eliminated pigs caused by high fever syndrome can be obviously reduced after the Chinese herbal medicine feed additive is applied.

At the beginning of the test, the average body weights of the pigs in groups 1 to 4 were 14.2 + -3.2, 13.7 + -3.1, 13.5 + -1.9 and 13.8 + -2.8 kg, respectively. The average weight of each group (no culled pig is added) at the end of the piglet stage is respectively 30.8 +/-5.0, 31.9 +/-4.9, 31.8 +/-4.8 and 31.7 +/-5.1 kg, the average daily weight gain is respectively 346, 377, 381 and 373g, and the daily weight gain of the Chinese herbal medicine feed additive group is obviously higher than that of the control group (P is less than 0.05). By the end of the growing pig stage, the average body weight of each group (excluded pigs) was 64.7 + -10.6, 67.3 + -10.6, 67.7 + -10.5 and 67.0 + -10.8 kg, and the daily gain was 611, 632, 634 and 630 g. Differences between groups in daily gain were not significant (P > 0.05). The feed weight ratio of each group is respectively 2.32, 2.20, 2.19 and 2.22 in the piglet stage and is respectively 2.63, 2.51, 2.49 and 2.51 in the growing pig stage, the feed consumption of each kilogram of weight gain is lower, and the Chinese herbal medicine feed additive group is lower than the antibiotic control group. In general, the growth rate and feed return of pigs using the herbal feed additive were higher than those of the control group using antibiotics.

When the test was performed for about 100 days, feed samples of pigs in groups 1 and 3 and fecal samples of pigs were collected, and digestion test was performed by 4N HCl insoluble ash method, and as a result, the digestibility of dry matter, crude protein, crude fat, crude fiber, crude ash, and nitrogen-free extract in groups 1 and 3 (herbal additive group 2) was (93.3 ± 1.5%), 94.9 ± 0.9%, (93.3 ± 1.3%), 94.4 ± 1.2%, (73.2 ± 5.7%), 79.0 ± 3.3%, (76.9 ± 5.2),% (82.8 ± 3.5%), 73.2 ± 5.7%, (78.8 ± 3.3%, (97.4 ± 0.7%) and (98.2 ± 0.4%), and the digestibility of the feed additive group was improved by 1.7%, and 7% respectively. From the above data, the nutrient with lower digestibility is improved to a greater extent, which indicates that the Chinese herbal medicine feed additive of the invention has the function of improving the pig digestibility.

In conclusion, the Chinese herbal medicine feed additive has a prevention and control effect on the hyperpyrexia syndrome of pigs, can obviously reduce the death and culling rate of the pigs suffering from hyperpyrexia, improves the weight gain speed, the digestibility of nutrient substances and improves the feed reward; and the Chinese herbal medicine feed additive is a pure natural substance, has no potential safety and residue problems like using antibiotics, and has wide application prospect.

Test example 3: (comparative test of different feed additives on pig productivity, economic benefit and immunity)

90 weaned piglets with the weight of about 8kg are selected, divided into 9 columns and 10 pigs in each column, and randomly divided into 3 groups, and each group comprises 30 pigs. The formal test was started after the pigs were tested for 10 days without abnormality. Wherein, one group (Chinese herbal medicine group) is fed with the Chinese herbal medicine feed additive (prepared by the formula of the example 5), the other group is fed with the plant extract additive (high-benefit group) produced by the biological technology limited company of Yingguorekang (Guangzhou), and the other group is only the compound feed (control group) self-prepared in the test pig farm. Wherein the Chinese herbal medicine feed is prepared by respectively adding 0.35%, 0.30% and 0.25% of Chinese herbal medicine feed additives into piglets, growing pigs and fattening pigs on the basis of the control group feed. The high-goodness high-group feed is prepared by respectively adding 0.08%, 0.06% and 0.05% of high-goodness high-additives on the basis of the control group feed. The three groups of the feed management measures are the same except for different additives. The production performance, mortality and elimination rate of the pigs of each treatment group were observed. 12 pigs were collected before the start of the test and at a weight of about 60kg per group to analyze the immune index, and swine fever antibodies were detected by collecting blood 29 days after inoculation of swine fever vaccine.

When the piglet stage test is started, the average body weight of each group is similar, and when the stage test is ended, the average body weight is sequentially a control group, a Chinese herbal medicine group and a high-benefit group from high to low, and the average daily feed intake, the average daily gain and the feed conversion efficiency are consistent in sequence, but the difference is very small (P is more than 0.05). The daily gain of the Chinese herbal medicine is 4.0 percent lower than that of the control group, and the feed consumption of unit gain is 1.8 percent higher; the daily gain of the Chinese herbal medicine is 1.9 percent higher than that of a good group, and the feed consumption of unit gain is 0.6 percent lower than that of a good group.

The results of the tests, the productivity of the pigs are shown in Table 1.

TABLE 1 comparison of Productivity of pigs tested in each group

Note: initial average body weights at the growing and finishing stages did not include body weights of dead or culled pigs at this stage.

In the growing stage of pigs, the average daily weight gain of the Chinese herbal medicine is 7.9 percent higher than that of a control group, and the feed consumption of unit weight gain is reduced by 8.4 percent compared with that of the control group; compared with the good group, the daily gain of the two groups is very close (99.96%), and the feed consumption of the unit gain is reduced by 4.3%. The daily gain of the high-performance group is increased by 7.9 percent compared with that of a control group, the feed consumption of unit weight gain is reduced by 4.3 percent, and the high-performance group also shows certain effects of promoting growth and improving the feed efficiency. At this stage, the average daily food intake of the Chinese herbal medicine group was the lowest, 1.2% and 4.3% lower than the control group and the good high group, respectively, but the comprehensive productivity was the highest among the three groups.

In the stage of fattening pigs, the average daily weight gain of the Chinese herbal medicines is 2.1 percent higher than that of a control group, the average daily feed intake is reduced by 5.1 percent, and the feed consumption of unit weight gain is reduced by 7.0 percent compared with that of the control group; compared with the Haoyao group, the daily gain is improved by 5.9 percent, the average daily feed intake is reduced by 7.2 percent, and the feed consumption of unit weight gain is reduced by 11.4 percent. The daily gain of the high-benefit group is 3.6 percent lower than that of the control group, the average daily feed intake is improved by 2.3 percent, the feed consumption of unit weight gain is reduced by 5.0 percent, and the comprehensive production performance of the high-benefit group is inferior to that of the control group.

In the whole test period, the average daily weight gain of the Chinese herbal medicine is respectively increased by 2.9 percent and 0.6 percent compared with the control group and the high-benefit group, the feed consumption of unit weight gain is respectively reduced by 5.7 percent and 5.4 percent, but the difference is not obvious (P is more than 0.05). From the test results, the Chinese herbal medicine feed additive has the tendency of improving the daily weight gain and the feed utilization rate of pigs.

The number of dead and culled pigs in each stage of the trial for the three groups is shown in table 2. During the test period, 3 pigs died in the control group, and 3 pigs were rejected due to the diseased cad; 1 pig died from the Chinese herbal medicine group, and 2 pigs were rejected; the high pigs died 4 and 3 were rejected. Compared with a control group and a good group, the Chinese herbal medicine has the mortality rate reduced by 66.7 percent and 75 percent, and the elimination rate is reduced by 33.3 percent and 33.3 percent. The Chinese herbal medicine pig has ruddy skin and bright hair color, and has certain health care and disease prevention effects.

TABLE 2 number of dead and culled pigs at different stages of the test for each group (head)

According to the method, the prices of market piglets and fat pigs are 12.8 yuan/kg at the end of the test, the prices of piglet feed, growing pig feed and fattening pig feed during the test are respectively 2.83 yuan/kg, 2.55 yuan/kg and 2.36 yuan/kg, the prices of Chinese herbal medicine feed additive and the high-yield additive are respectively 36 yuan/kg and 100 yuan/kg, the prices of piglet feed, growing pig feed and fattening pig feed of the Chinese herbal medicine are calculated according to the using amount of the additive and are respectively 2.956 yuan/kg, 2.658 yuan/kg and 2.45 yuan/kg, the prices of piglet feed, growing pig feed and fattening pig feed of the high-yield group are respectively 2.91 yuan/kg, 2.61 yuan/kg and 2.41 yuan/kg, the hair profit after the piglet cost and the feed cost are deducted from the Chinese herbal medicine feed group is calculated is increased by 2916.84 yuan compared with that of the control group, and is increased by 4913.97 yuan compared with that of the high-yield group. That is, the amount of the Chinese herbal medicine in each pig is more than 97.23 yuan in comparison with the control group and more than 163.80 yuan in comparison with the benefit group. The economic benefit obtained by adding Chinese herbal medicines is very obvious.

The immune index and the detection result of the swine fever antibody are shown in Table 3.

TABLE 3 immune index and swine fever antibody test results of each treatment group

Detecting items	Chinese herbal medicine	High group of great benefit	Control group
				α-IFN(pg/ml)	36.63±20.6	35.92±15.41	40.16±14.50
IL-2(ng/ml)	6.41±3.58	5.17±2.40	7.05±3.52
				CD4(u/ml)	6.72±2.20	6.57±1.29	6.44±1.49
CD3(u/ml)	7.62±8.91	5.42±2.77	5.27±5.01
				CD8(u/ml)	27.47±44.07	12.79±8.37	18.58±32.87
C3(μg/ml)	19.34±17.74	12.14±6.38	8.39±8.38
				C4(μg/ml)	1.14±1.55	0.71±0.34	0.80±0.70
IgA(g/l)	0.89±0.22	0.72±0.17	0.78±0.23
				IgM(g/l)	1.23±1.16	1.15±0.33	1.22±0.33

Detecting items	Chinese herbal medicine	High group of great benefit	Control group
				IgG(g/l)	8.00±1.86	6.79±2.50	9.13±1.91
Antibody positive for hog cholera	10/12	5/12	5/12

As can be seen from Table 3, the other 7 index Chinese herbal medicines except for alpha-IFN, IL-2 and IgG are all higher than the control group; all immunity index values were higher than those in the good high group. Jingchi type²The test shows that the Chinese herbal medicine feed additive has very obvious effect (P is less than 0.005) on improving the generation of the antibody of the swine fever vaccine. Illustrating the Chinese herbal medicine feed additive of the inventionHas certain function of improving the immunity of the organism.

Experimental example 4: (comparative tests of different feed additives on pig Productivity, Swine fever antibody and pathogen detection)

Selecting 60 weaned piglets with similar weight and age of day, and dividing into 6 rows, 3 rows in each group, and 30 pigs. A control group feeding field self-prepared compound feed is added into a test group, the Chinese herbal medicine feed additive (0.35 percent in piglet feed, 0.30 percent in growing pig feed and 0.25 percent in fattening pig feed) with the formula in the embodiment 8 is added into the control group feed, the production performance of pigs is observed, 4 pigs are extracted for blood sampling to detect swine fever antibodies 29 days after inoculation of swine fever vaccines, 4 pigs are extracted for blood sampling before and 5 months after the test, RNA is extracted, and the pathogeny of blue ear disease (PRRS) and Japanese encephalitis (JBE) is analyzed by an RT-PCR method.

The production performance of pigs fed with the herbal feed additive of the invention was compared with that of the control group as shown in Table 4.

Table 4 experimental example 4 comparison of the productivity of differently treated pigs

Item	Chinese herbal medicine	Control group	Comparison of
				Mean body weight (kg) at the beginning of the test	11.98±1.68	12.26±1.49	97.72
Average weight (kg) at piglet end	49.91±4.82	50.62±5.62	98.60
				Average weight (kg) at the end of growing pigs	75.89±7.98	73.43±9.09	103.35
Average weight (kg) at finishing of fattening pig	110.81±10.21	107.17±10.25	103.40
				Average daily gain (g) of piglets	621.8±70.9	628.9±85.0	98.87
Average daily gain (g) of growing pig	742.3±140.5	677.5±122.5	109.56
				Average daily gain (g) of fattening pig	812.1±128.5	762.7±211.9	106.48
Average daily gain (g) over the whole period	711.0±73.6	683.1±73.4	104.08
				Piglet stage feed weight ratio	2.22±0.19	2.23±0.15	99.34
Feed-to-weight ratio in growing pig stage	3.01±0.05	3.33±0.19	90.27
				Feed weight ratio of fattening pig stage	3.89±0.21	4.61±0.18	84.51

Item	Chinese herbal medicine	Control group	Comparison of
				At the whole stageMaterial to weight ratio	2.97	3.25	91.38
Total consumptive material (kg)	7973.26	8217.05	97.03
				Total weight gain (kg)	2682.46	2530.83	105.99

Although the daily gain of the fed Chinese herbal medicine pig is 1.4 percent lower than that of a control group in a piglet stage, the daily gain of the fed Chinese herbal medicine pig is respectively increased by 9.56 percent and 6.48 percent compared with that of the control group in a growing stage and a fattening stage, the average daily gain of the whole stage is increased by 4.1 percent, the feed consumed by each kilogram of weight gain is respectively reduced by 0.6 percent, 9.7 percent and 15.5 percent in the piglet stage, the growing stage and the fattening stage, and the whole stage is reduced by 8.6 percent.

The results of the detection of the hog cholera antibodies and the pathogen are shown in Table 5.

TABLE 5 hog cholera antibody and pathogen detection results of Chinese herbal medicine and control group pigs

Item	Chinese herbal medicine	ControlGroup of
			Hog cholera antibody (negative number/detection number)	1/12	4/12
PRRS pathogen positivity (number of positives/number of detections)	12/12	12/12
			JBE pathogen positivity (number of positive/number of test)	0/12	1/12

The detection shows that the vaccine inoculation failure (swine fever antibody negative) of swine fever is 1 in the Chinese herbal medicine, 4 in the control group and chi²The difference is significant (P < 0.05) by inspection. The porcine reproductive and respiratory syndrome virus was positive in both groups because the pigs were vaccinated against porcine reproductive and respiratory syndrome. The encephalitis B virus is negative before the test is started, the Chinese herbal medicine group still keeps negative after the spot check 5 months after the test is started, and the control group has 1 positive, so that the Chinese herbal medicine is presumed to have a certain prevention effect on epidemic encephalitis B.

Test example 5: (comparison test of pig productivity, mortality and elimination rate with different feed additives)

120 weaned piglets with the weight of about 10kg and the age of day close to each other are selected, the weaned piglets are divided into 8 groups, 15 pigs in each group are randomly divided into 2 groups, 4 pigs in each group and 60 pigs in each group, and two adjacent pigs in the same group share one trough. The control group feeding farm self-prepared compound feed, the Chinese herbal medicine test group added the Chinese herbal medicine feed additive prepared according to the formula of example 5 (0.35% in the piglet feed, 0.30% in the growing pig feed and 0.25% in the fattening pig feed) on the basis of the control group feed, the production performance of the pigs was examined, and the number of dead pigs and the number of rejected pigs were recorded. The results are shown in Table 6.

TABLE 6 test results of pig productivity, mortality and culling

Item	Chinese herbal medicine	Control group
			Average daily gain (g) in piglet stage	527.9±87.5	492.8±88.6g
Average daily gain (g) in growing pig stage	668.2±165.5	651.4±137.6

Item	Chinese herbal medicine	Control group
			Average daily gain (g) over the whole period	603.5±89.2	582.3±100.5
Piglet stage feed weight ratio	1.65	1.75
			Feed-to-weight ratio in growing pig stage	1.79	1.85
Material to weight ratio at full stage	1.82	1.73
			Pig mortality (%)	0	1.7
Pig culling rate (%)	0	1.7
			Number of pigs biting into tail (head)	5	10

In the piglet stage, the daily gain of the Chinese herbal medicine pig is increased by 7.2 percent compared with that of a control group, and the daily gain of the growing pig is increased by 2.6 percent; the Chinese herbal medicines are saved by 5.9 percent and 3.6 percent respectively compared with the control group when the weight of each kilogram of the feed is increased; the Chinese herbal medicine for the whole-period daily gain is improved by 3.6 percent compared with the control group, and the feed consumption of each kilogram of gain is reduced by 4.6 percent. The Chinese herbal medicine group has no pig death or elimination in the test period, and the pig death rate and elimination rate are reduced by 1.7 percent compared with those of a control group. The number of pigs with tail biting is half less than that of the control group.

From the test examples, the Chinese herbal medicine feed additive has the effects of preventing and controlling the high fever syndrome of the pigs, improving the growth speed, the feed utilization efficiency and the economic benefit of the pigs, improving the organism immunity of the pigs, reducing the allotriophagy of the pigs and the like.

Claims (7)

1. The Chinese herbal medicine feed additive for preventing and controlling the high fever syndrome of pigs is characterized in that the raw material medicines of the additive and the raw material medicines are in parts by weight: 2-8 parts of angelica sinensis, 2-5 parts of radix paeoniae alba, 8-12 parts of scutellaria baicalensis, 4-6 parts of folium artemisiae argyi, 5-8 parts of rhizoma atractylodis, 8-12 parts of hawthorn, 2-5 parts of mangnolia officinalis, 5-8 parts of pericarpium citri reticulatae and 4-6 parts of liquorice.

2. The additive as claimed in claim 1, wherein the raw material medicine of the additive comprises the following raw material medicines in parts by weight: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae and 5 parts of liquorice.

3. The additive as claimed in claim 1, wherein the additive comprises the following raw material herbs in parts by weight: 2-5 parts of codonopsis pilosula, 8-12 parts of medicated leaven and 3-7 parts of poria cocos.

4. The additive as claimed in claim 3, wherein the raw material medicine of the additive comprises the following raw material medicines in parts by weight: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae, 5 parts of liquorice, 3 parts of codonopsis pilosula, 10 parts of medicated leaven and 5 parts of poria cocos.

5. The additive as claimed in claim 3, wherein the additive comprises the following raw material herbs in parts by weight: 3-7 parts of sweet wormwood, 3-8 parts of radix sophorae flavescentis and 3-8 parts of Chinese pulsatilla root.

6. The additive as claimed in claim 5, wherein the raw material medicine of the additive comprises the following raw material medicines in parts by weight: 5 parts of angelica, 3 parts of white peony root, 10 parts of scutellaria baicalensis, 5 parts of folium artemisiae argyi, 7 parts of rhizoma atractylodis, 10 parts of hawthorn, 3 parts of mangnolia officinalis, 7 parts of pericarpium citri reticulatae, 5 parts of liquorice, 3 parts of codonopsis pilosula, 10 parts of medicated leaven, 5 parts of poria cocos, 5 parts of sweet wormwood, 5 parts of radix sophorae flavescentis and 5 parts of Chinese pulsatilla root.

7. A process for the preparation of the additive according to claim 1, 2, 3, 4, 5 or 6, characterized in that it is carried out by the following steps:

(1) drying and crushing the raw material medicines: drying the raw materials in the sun or in an oven at 60 deg.C; weighing each dry raw material medicine according to a formula; pulverizing the dried raw materials except fructus crataegi and folium Artemisiae Argyi with pulverizer respectively, sieving with 60 mesh sieve, and mixing;

(2) and (3) processing the hawthorn: pulverizing dried fructus crataegi with pulverizer, sieving with 60 mesh sieve, removing hard shell on the sieve, and retaining powder under the sieve;

(3) processing the folium artemisiae argyi: pulverizing dried folium Artemisiae Argyi with pulverizer, and sieving with 60 mesh sieve; decocting the screened large-volume floccules twice with water, wherein the water amount is preferably larger than the medicine surface each time, soaking for 6 hours for the first time, heating and decocting for 30 minutes, and soaking for 2 hours for the second time, and decocting for 30 minutes; cooling each time, squeezing and filtering with 200 mesh nylon screen cloth, mixing extractive solutions, and heating and concentrating to one tenth of original volume; pouring the concentrated solution into sieved folium Artemisiae Argyi powder, stirring, oven drying at 60 deg.C, cooling, and pulverizing into powder;

(4) mixing of the additive: and (3) adding the hawthorn powder in the step (2) and the folium artemisiae argyi powder in the step (3) into the mixed powder in the step (1), and uniformly mixing to obtain the Chinese herbal medicine feed additive.