CN105497224A - Anti-viral traditional Chinese medicine micro-ecological preparation for livestock and poultry and preparation method of anti-viral traditional Chinese medicine micro-ecological preparation - Google Patents
Anti-viral traditional Chinese medicine micro-ecological preparation for livestock and poultry and preparation method of anti-viral traditional Chinese medicine micro-ecological preparation Download PDFInfo
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Abstract
The invention discloses an anti-viral traditional Chinese medicine micro-ecological preparation for livestock and poultry and a preparation method of the anti-viral traditional Chinese medicine micro-ecological preparation and belongs to the technical field of veterinary drugs. The traditional Chinese medicine micro-ecological preparation is mainly prepared from fermentation strains and the following traditional Chinese medicine raw materials through mixing and fermentation: fineleaf schizonepeta herbs, divaricate saposhnikovia roots, Poria cocos, pubescent angelica roots, Chinese thorowax roots, hogfennel roots, Szechuan lovage rhizomes, orange fruits, incised notopterygium rhizomes or roots, platycodon roots, mint and liquorice roots; the fermentation strains comprise Lactobacillus plantarum strains, Lactobacillus acidophilus strains, Bifidobacterium strains, Enterococcus faecalis strains and yeast strains. The anti-viral traditional Chinese medicine micro-ecological preparation for the livestock and poultry is high in utilization rate, good to absorb, low in cost and free of toxic and side effects, has functions of maintaining balance of intestinal floras and enhancing the immunity of the livestock and poultry, and has the significant effect in preventing and treating viral diseases of the livestock and poultry.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of poultry anti virus herb microbial ecological agent and preparation method thereof.
Background technology
At present, along with the fast development of livestock and poultry breeding industry, animal viral disease also increases gradually, as reproductive and respiratory syndrome, circovirus disease, influenza; Infectious bursal disease, newcastle etc., propagate wider at livestock and poultry farm, and there is new popularity, as acute case reduces, mild infects, mixed infection increases, cause low and production cost raising of immunosuppressant, immuning failure, the rate of animals delivered to the slaughter-house etc., cause serious economic loss to aquaculture.
From 2005, antiviral Western medicine is as amantadine, rimantadine, ribavirin, acyclovir, morpholine (two) guanidine etc., forbid in edible animal comprehensively, this results in the minimizing of available antiviral drugs in aquaculture, and when using vaccine immunity, due to the ubiquity of immunosuppressive disease, make humoral immunization and cellular immune function suffer grievous injury, cause the vaccine eliminating epidemic disease performance pivotal role to play a role, cause the cell of the virus of intraor extracellular and viral infection not to be eliminated.Chinese herbal medicine has biological homology in disease therapy, and action function is many, and side effect is little, and the advantage such as wide of originating, therefore, the antivirus action of Chinese medicine more and more comes into one's own.Chinese medicine prescription Antiphlogistic Powder of Schizonepetae and Ledebouriellae, is sieved through pulverizing by 14 taste Chinese medicines such as Herba Schizonepetae, Radix Saposhnikoviae, Poria, Radix Angelicae Pubescentis, Radix Bupleuri, Rhizoma Chuanxiongs, and mixing is prepared and obtains.Existing many researcheres prove, it is evident in efficacy that Jingfang toxicity-removing is dispersed in the above-mentioned disease aspect of control.But complicated and changeable along with pathophoresis and extraneous factor, the problems such as often occur slow curative effect when conventional Jingfang toxicity-removing is dispersed in application, utilization rate is low, and action effect is unstable.Therefore, for the control of animal viral disease, need to be sought a kind of instant effect, good absorbing, Chinese medicine preparation that availability is high.
Summary of the invention
The object of this invention is to provide a kind of poultry anti virus herb microbial ecological agent, this Chinese medicine microecological preparation absorbance is high, instant effect, to have no side effect, high for preventing and treating animal viral disease effective percentage.
Second object of the present invention is to provide the preparation method of a kind of poultry anti virus herb microbial ecological agent.
In order to realize above object, the technical solution adopted in the present invention is:
A kind of poultry anti virus herb microbial ecological agent, the raw material of Chinese medicine mixed culture fermentation primarily of fermented bacterium and following parts by weight is made: Herba Schizonepetae 35 ~ 55 parts, Radix Saposhnikoviae 20 ~ 40 parts, 35 ~ 55 parts, Poria, Radix Angelicae Pubescentis 15 ~ 35 parts, Radix Bupleuri 20 ~ 40 parts, Radix Peucedani 15 ~ 35 parts, Rhizoma Chuanxiong 15 ~ 35 parts, Fructus Aurantii 20 ~ 40 parts, Rhizoma Et Radix Notopterygii 15 ~ 35 parts, Radix Platycodonis 20 ~ 40 parts, Herba Menthae 5 ~ 25 parts, 5 ~ 25 parts, Radix Glycyrrhizae; The consumption of described fermented bacterium is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds Lactobacillus plantarum strain 35 ~ 45mL, Lactobacillus acidophilus species 15 ~ 25mL, bifidobacterium species 35 ~ 45mL, enterococcus faecalis strain 10 ~ 30mL, yeast seeds 20 ~ 40mL.
Above-mentioned poultry anti virus herb microbial ecological agent, is made up of described fermented bacterium, raw material of Chinese medicine and fermenting additive mixed culture fermentation; The consumption of described fermenting additive is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds cellulase 8 ~ 12g, phytase 8 ~ 12g, maltose 3 ~ 8g, sodium acetate 1 ~ 3g, potassium dihydrogen phosphate 0.4 ~ 0.8g.
Preferably, described poultry anti virus herb microbial ecological agent, the raw material of Chinese medicine mixed culture fermentation primarily of fermented bacterium and following parts by weight is made: Herba Schizonepetae 45 parts, Radix Saposhnikoviae 30 parts, 45 parts, Poria, Radix Angelicae Pubescentis 25 parts, Radix Bupleuri 30 parts, Radix Peucedani 25 parts, Rhizoma Chuanxiong 25 parts, Fructus Aurantii 30 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Platycodonis 30 parts, Herba Menthae 15 parts, 15 parts, Radix Glycyrrhizae; The consumption of described fermented bacterium is: the Herba Schizonepetae correspondence of every 45g adds Lactobacillus plantarum strain 40mL, Lactobacillus acidophilus species 20mL, bifidobacterium species 40mL, enterococcus faecalis strain 20mL, yeast seeds 30mL.
Above-mentioned poultry anti virus herb microbial ecological agent, is made up of described fermented bacterium, raw material of Chinese medicine and fermenting additive mixed culture fermentation; The consumption of described fermenting additive is: the Herba Schizonepetae correspondence of every 45g adds cellulase 10g, phytase 10g, maltose 5g, sodium acetate 2g, potassium dihydrogen phosphate 0.7g.
Described Lactobacillus plantarum strain viable count is 1.0 ~ 3.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 1.0 ~ 3.0 × 10
8cFU/mL, bifidobacterium species viable count are 4.0 ~ 6.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 2.0 ~ 4.0 × 10
8cFU/mL, yeast seeds viable count are 3.0 ~ 5.0 × 10
8cFU/mL.
A kind of above-mentioned poultry preparation method of anti virus herb microbial ecological agent, comprise raw material of Chinese medicine, fermented bacterium and the fermenting additive of getting formula ratio, load hermetic container after mix homogeneously, after 32 ~ 42 DEG C of fermentation 72 ~ 144h, dry and obtain poultry anti virus herb microbial ecological agent.
Described fermenting additive is: cellulase, phytase, maltose, sodium acetate and potassium dihydrogen phosphate; The consumption of fermenting additive is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds cellulase 8 ~ 12g, phytase 8 ~ 12g, maltose 3 ~ 8g, sodium acetate 1 ~ 3g, potassium dihydrogen phosphate 0.4 ~ 0.8g.
Described bake out temperature is 40 ~ 50 DEG C.
Preferably, the above-mentioned poultry preparation method of anti virus herb microbial ecological agent, comprise the raw material of Chinese medicine getting formula ratio, fermented bacterium and fermenting additive, the parts by weight of raw material of Chinese medicine are: 35 ~ 55 parts, Herba Schizonepetae powder, Radix Saposhnikoviae powder 20 ~ 40 parts, Poria powder 35 ~ 55 parts, 15 ~ 35 parts, Radix Angelicae Pubescentis powder, 20 ~ 40 parts, Radix Bupleuri powder, front English white 15 ~ 35 parts, Rhizoma Chuanxiong power 15 ~ 35 parts, 20 ~ 40 parts, Fructus Aurantii powder, 15 ~ 35 parts, Rhizoma Et Radix Notopterygii powder, balloonflower powder 20 ~ 40 parts, Herba Menthae powder 5 ~ 25 parts, Radix Glycyrrhizae powder 5 ~ 25 parts, the consumption of fermented bacterium is: the Herba Schizonepetae powder correspondence of every 35 ~ 55g adds Lactobacillus plantarum strain 35 ~ 45mL, Lactobacillus acidophilus species 15 ~ 25mL, bifidobacterium species 35 ~ 45mL, enterococcus faecalis strain 10 ~ 30mL, yeast seeds 20 ~ 40mL, the consumption of fermenting additive is: the Herba Schizonepetae powder correspondence of every 35 ~ 55g adds cellulase 8 ~ 12g, phytase 8 ~ 12g, maltose 3 ~ 8g, sodium acetate 1 ~ 3g, potassium dihydrogen phosphate 0.4 ~ 0.8g, load hermetic container after mix homogeneously, after 32 ~ 42 DEG C of fermentation 72 ~ 144h, dry and obtain poultry anti virus herb microbial ecological agent.
Preferably, the condition of fermentation is 35 DEG C of fermentation 120h.
Preferably, the temperature of oven dry is 45 DEG C.
Poultry of the present invention anti virus herb microbial ecological agent, the feature of each raw material is as follows:
Herba Schizonepetae: be Labiatae Schizonepeta tenuifolia platymiscium Schizonepeta tenuifolia and the stem and leaf and the spica that split page Herba Schizonepetae more; Containing volatile oil as pulegone, menthone, isomenthone, neomenthol etc., monoterpenes, as schizonepetoside A, B, C, D, E, also contains flavonoid chicken liposoluble ingredient.Pungent, the micro-hardship of property, tepor; Return lung, Liver Channel; Effect, for dispeling the wind, is induced sweat, rash, hemostasis; Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, furuncle, spit blood, have blood in stool, metrorrhagia, puerperal blood faints.Modern pharmacology research shows, Herba Schizonepetae has antipyretic, cooling, calmness, analgesia, antiinflammatory, hemostasis and antioxidation, antimicrobial effect.
Radix Saposhnikoviae: be the root of Umbelliferae Radix Saposhnikoviae platymiscium Radix Saposhnikoviae, containing containing Radix Saposhnikoviae keto-alcohol, 4 '-O-glucosyl group-5-O-methyl visamminol, last of the twelve Earthly Branches thatch alcohol isochrome ketone, the Coumarinses such as fragrant glycosides lactone, psoralen, imperatorin, the effective ingredient such as the carbene such as Panaxynol, falcarindiol class.Property is pungent, sweet, tepor; Return bladder, lung, spleen channel; Effect is expelling pathogenic wind from the body surface, removing dampness to relieve pain, and relieving convulsion is antipruritic; Cure mainly affection of exogenous wind-cold, migraine and general headache, rheumatic arthralgia, stomachache is had loose bowels, discharging fresh blood stool, tetanus, infantile convulsion, rubella pruritus, skin infection from the beginning of.Modern pharmacology research shows, Radix Saposhnikoviae has antipyretic, cooling, calmness, analgesia, convulsion, antiinflammatory, antibacterial, antitumor and immunoregulatory effect.
Poria: for Polyporaceae hole of crouching belongs to the sclerotium of fungus Poria, containing triterpenes as pachymic acid, 16 Alpha-hydroxy red holes acid, β-para hydroxybenzene acyl group dehydroeburicoic acid etc., polysaccharide as pachyman, the effective ingredient such as pachymaran.Property is sweet, light, flat; GUIXIN, spleen, lung, kidney channel; Effect is promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, to have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.Modern pharmacology research show, Poria have diuresis, preventing gastric ulcer, anticancer and strengthen immunity effect.
Radix Angelicae Pubescentis: be the root of the heavy tooth Radix Angelicae Sinensis of Umbelliferae archangel, containing coumarin kind compound columbianetin and acetas thereof, osthole, different imperatorin, fragrant glycosides lactone, xanthotoxin etc.; Volatile oil is as effective ingredient such as Buddhist art alkene, thymol, eneα-cedars.Property bitter, pungent, tepor; Return kidney, urinary bladder channel; Effect is expelling wind and dampness, dispersing cold for relieving pain; Cure mainly anemofrigid-damp arthralgia, lumbocrural pain, headache toothache.Modern pharmacology research shows, Radix Angelicae Pubescentis has analgesia, calmness, antiinflammatory, photosensitive, spasmolytic, antitumor, antibacterial effect, and mouse experiment proves, Radix Angelicae Pubescentis has anticoagulant and antithrombotic effect.
Radix Bupleuri: be the root of Umbelliferae Bupleunim. L Radix Bupleuri or Radix Bupeuri Scorzonerfolii., containing volatile oil as o-methoxyphenol, heptalactone, caprylolactone, decalactone, eugenol, undecalactone etc., also contain saponins as saikoside, acetyl saikoside, flavonoid is as the effective ingredient such as rutin, Quercetin.Bitter, pungent, be slightly cold, return liver, gallbladder meridian; Effect is brought down a fever for inducing sweat, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Cure mainly fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI mammary swelling, headache dizziness, menoxenia, proctoptosis, the uterus of collapse of QI hang, gastroptosis.Modern pharmacology research shows, Radix Bupleuri has antiinflammatory, antipyretic, calm, analgesia, antitussive, protects the liver, protects the effects such as stomach, blood fat reducing, anti-bacteria and anti-virus, antitumor, promotion metabolism.
Radix Peucedani: be the root of Umbelliferae Peucedanum plant Peucedanum praeruptorum DUNN and RADIX PEUCEDANI, containing raceme praeruptorin A, dextrorotation praeruptorin C, D, E, pteryxin, Radix Peucedani phase legumin A, the coumarin kind compounds such as psoralen, coumarin glycoside compounds and other effective ingredient such as nodakenin, India's glycosides, skimmin.Property bitter, pungent, be slightly cold; Return lung, spleen, Liver Channel; Effect is dispelling wind and heat pathogens, lowering the adverse-rising QI to resolve phlegm; Cure mainly affection due to external wind and heat, lung-heat phlegm stagnancy.Cough with asthma abundant expectoration, expectorant is yellow thick glutinous, vomiting lack of appetite, and chest and diaphragm is full vexed.Modern pharmacology research shows, the effects such as Radix Peucedani has antiplatelet aggregation, arrhythmia, eliminate the phlegm.
Rhizoma Chuanxiong: be the rhizome of Umbelliferae Ligustrum plant Rhizoma Chuanxiong, containing multiple lactones such as ligustrazine, loline, perlolyrine, ligustilide, Rhizoma Chuanxiong naphthalene furan lactones, also containing the plurality of active ingredients such as phenolic acids, volatile oil.Property is pungent, warm, returns liver, gallbladder, pericardium channel; Effect is blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; Cure mainly menoxenia, amenorrhea dysmenorrhea, the stasis of blood in puerperal stagnant stomachache ， WEIJIA lump, pain in chest and hypochondrium, has a headache dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.Modern pharmacology research shows, Rhizoma Chuanxiong has enhancing systema cariovasculare functional (as blood vessel dilating, suppress hypertension, to resist myocardial ischemia and Reperfusion injury injures protective effect etc. to cerebral ischemia), strengthens hematological function, strengthens the effect such as urinary system and function of immune system, antitumor, anti-radiation.
Fructus Aurantii: be Rutaceae citrus plant Citrus aurantium Linn. and cultivation product green fruit thereof, containing flavonoid as effective ingredient such as Hesperidin, alkaloid, limonins; Property bitter, sour, temperature, returns lung, spleen, stomach, large intestine channel.Effect is the chest stuffiness relieving of regulating the flow of vital energy, the stagnant removing food stagnancy of row; Cure mainly the acid of chest and diaphragm band, distending pain over the hypochondrium, accumulation of food in the stomach and intes tine due to indigestion, distension and fullness in the abdomen, heavy after dysentery, uterine prolapse.Modern pharmacology research proves, Fructus Aurantii has enhancing systema cariovasculare functional, promotes the effects such as gastrointestinal.
Rhizoma Et Radix Notopterygii: be rhizome and the root of Umbelliferae Notopterygium plant Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii, containing coumarin kind compounds such as different imperatorin, the different imperatorin of 8-methoxyl group, fragrant glycosides lactone 5 '-hydroxyl bergmot elements, the phytosterin compounds such as cupreol glucoside, cupreol, and the effective ingredient such as α-thujene.Property pungent, bitter, temperature, return bladder, kidney channel; Effect is loose exterior cold, wind-damp dispelling, sharp joint, pain relieving, pain relieving; Cure mainly affection of exogenous wind-cold, have a headache lossless, anemofrigid-damp arthralgia, edema due to wind pathogen edema, sore swollen toxin.Modern pharmacology research proves, Rhizoma Et Radix Notopterygii has antipyretic, analgesia, antiinflammatory, antiallergic, increase cerebral blood flow, arrhythmia, antithrombus formation, epilepsy, antioxidation, antibacterial effect.
Radix Platycodonis: be the root of campanulaceae Platycodon grandiflouorum Platycodon grandiflouorum; Containing effective ingredient such as platycodin, sapogenin, sterols.Bitter in the mouth, property is put down, and returns lung meridian; Effect for opening lung qi dispersing gas, evacuation of pus of eliminating the phlegm; The diseases such as be used for the treatment of exogenous cough, laryngopharynx swelling and pain, lung abscess is spat, fullness in the chest and hypochondriac pain, dysentery stomachache." pearl sac " is recorded: " passing through with Radix Glycyrrhizae, is drugs of guiding other drugs to act on upper JIAO ".Radix Platycodonis has many-sided pharmacological action, is wherein a most important ring to the regulating and controlling effect of macrophage, is one of the mechanism of action of Radix Platycodonis antiinflammatory, antitumor, resisting pathogenic microbes.
Herba Menthae: be herb or the leaf of Labiatae mint Herba Menthae, containing volatile oil, left-handed menthone, isomenthone, pulegone, decyl acetate, menthyl acetate, the effective ingredient such as essence of Niobe.Property is pungent, cool; Return lung, Liver Channel; Cure mainly dispelling wind-heat, the clear sharp head, sore-throat relieving, rash, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly wind heat exterior syndrome, headache conjunctival congestion, laryngopharynx swelling and pain, measles without adequate eruption, rubella pruritus, hypochondriac pain due to stagnation of liverQI.Modern pharmacology research proves that Herba Menthae has spasmolytic, hepatic cholagogic, antiearly pregnancy antiinflammatory, promotes Transdermal absorption, antimicrobial effect, take the effect that a small amount of Herba Menthae has excited cental system, Herba Menthae preparation topical application can make skin mucosa vasoconstriction, Oleum menthae external can benumb teleneuron, has refrigerant, antiinflammatory, pain relieving and antipruritic effect.
Radix Glycyrrhizae: be the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat., containing plurality of active ingredients such as triterpene saponin, flavone compound, coumarin kind compound, alkaloids and polysaccharide; Property sweet, flat, return spleen, stomach, the heart, lung meridian.Effect is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Cure mainly weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, dirty dry, consumptive lung disease is coughed, laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle and medicine, alimentary toxicosis.Modern pharmacology research proves that Radix Glycyrrhizae has antimicrobial, improves systema cariovasculare functional, facilitating digestion, protects the liver, antiinflammatory, ease pain, eliminate the phlegm, improve the effects such as function of immune system, antitumor, mutation, removing toxic substances, antioxidation.
Lactobacillus plantarum, Lactobacillus acidophilus species, bacillus bifidus, enterococcus faecalis, saccharomycetic effect are: be supplemented with bacteria group, maintain microecological balance; Nutrition digestion-aid effect; Improve immunity of organisms; Play health invigorating, control the pathogenetic effect of disease.
Poultry of the present invention anti virus herb microbial ecological agent, Herba Schizonepetae, Radix Saposhnikoviae, Poria, Radix Angelicae Pubescentis, Radix Bupleuri, Radix Peucedani, Rhizoma Chuanxiong, Fructus Aurantii, Rhizoma Et Radix Notopterygii, Radix Platycodonis, Herba Menthae, Radix Glycyrrhizae 12 taste Chinese medicine and the composite fermentation of microorganism is adopted to obtain, wherein Radix Bupleuri has more significant antivirus action, Radix Saposhnikoviae, Radix Angelicae Pubescentis, Herba Schizonepetae have anti-inflammatory and analgesic effect, Radix Glycyrrhizae, Fructus Aurantii, Radix Platycodonis have preventing phlegm from forming and stopping coughing effect, Herba Menthae, Radix Glycyrrhizae energy anti-liver injury, Radix Bupleuri, Radix Peucedani, Rhizoma Et Radix Notopterygii heat clearing away successful, Poria then has diuresis etc.The Chinese medicine undergone microbial fermentation, i.e. Chinese medicine microecological preparation, Chinese medicine ingredients wherein, through microbial transformation, is decomposed into small-molecule substance by macromolecular substances, rapid-action, drug effect is high, 100% absorbed by body; Can decompose the toxicant of Chinese herbal medicine in sweat, medicine noresidue, has no side effect, safe and reliable simultaneously.So, adopt Chinese medicine microecological preparation to prevent and treat viral disease, will the effect of getting twice the result with half the effort be reached.
The preparation method of the Chinese medicine microecological preparation for preventing and treating chicken proventriculitis disease of the present invention, easy to operate, simple, without medicine residue after fermentation, fermentation utilization rate is high, and feasibility is good, is applicable to wide popularization and application.
The usage of described poultry anti virus herb microbial ecological agent is: add Chinese medicine microecological preparation of the present invention 2000 ~ 4000 grams in feedstuff per ton and throw something and feed.During treatment, adding Chinese medicine microecological preparation of the present invention 4000 grams and throw something and feed in feedstuff per ton, 3 ~ 5 days is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add Chinese medicine microecological preparation of the present invention 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1
The poultry anti virus herb microbial ecological agent of the present embodiment, is made up of following raw material mixed culture fermentation: Herba Schizonepetae powder 35g, Radix Saposhnikoviae powder 20g, Poria powder 55g, Radix Angelicae Pubescentis powder 15g, Radix Bupleuri powder 40g, front English white 35g, Rhizoma Chuanxiong power 15g, Fructus Aurantii powder 20g, Rhizoma Et Radix Notopterygii powder 35g, balloonflower powder 40g, Herba Menthae powder 5g, Radix Glycyrrhizae powder 25g, Lactobacillus plantarum strain 35mL, Lactobacillus acidophilus species 25mL, bifidobacterium species 35mL, enterococcus faecalis strain 30mL, yeast seeds 20mL, cellulase 8g, phytase 12g, maltose 3g, sodium acetate 3g, potassium dihydrogen phosphate 0.4g.
The poultry anti virus herb microbial ecological agent of the present embodiment, the viable count of described Lactobacillus plantarum strain is 1.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 2.0 × 10
8cFU/mL, bifidobacterium species viable count are 4.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 4.0 × 10
8cFU/mL, yeast seeds viable count are 5.0 × 10
8cFU/mL.
The poultry preparation method of anti virus herb microbial ecological agent of the present embodiment, loads hermetic container after comprising the raw material mix homogeneously getting formula ratio, after 32 DEG C of fermentation 144h, dries and obtain poultry anti virus herb microbial ecological agent for 40 DEG C.
The usage of the poultry anti virus herb microbial ecological agent of the present embodiment is: during treatment, adds gained Chinese medicine microecological preparation 4000 grams and throw something and feed in feedstuff per ton, within 3 ~ 5 days, is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add gained Chinese medicine microecological preparation 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Embodiment 2
The poultry anti virus herb microbial ecological agent of the present embodiment, be made up of following raw material mixed culture fermentation:: Herba Schizonepetae powder 40g, Radix Saposhnikoviae powder 25g, Poria powder 50g, Radix Angelicae Pubescentis powder 20g, Radix Bupleuri powder 35g, front English white 30g, Rhizoma Chuanxiong power 20g, Fructus Aurantii powder 25g, Rhizoma Et Radix Notopterygii powder 30g, balloonflower powder 35g, Herba Menthae powder 10g, Radix Glycyrrhizae powder 20g, Lactobacillus plantarum strain 45mL, Lactobacillus acidophilus species 15mL, bifidobacterium species 45mL, enterococcus faecalis strain 10mL, yeast seeds 40mL, cellulase 12g, phytase 8g, maltose 8g, sodium acetate 1g, potassium dihydrogen phosphate 0.8g.
The poultry anti virus herb microbial ecological agent of the present embodiment, the viable count of described Lactobacillus plantarum strain is 2.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 1.0 × 10
8cFU/mL, bifidobacterium species viable count are 6.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 3.0 × 10
8cFU/mL, yeast seeds viable count are 4.0 × 10
8cFU/mL.
The poultry preparation method of anti virus herb microbial ecological agent of the present embodiment, loads hermetic container after comprising the raw material mix homogeneously getting formula ratio, after 37 DEG C of fermentation 96h, dries and obtain poultry anti virus herb microbial ecological agent for 45 DEG C.
The usage of the poultry anti virus herb microbial ecological agent of the present embodiment is: during treatment, adds gained Chinese medicine microecological preparation 4000 grams and throw something and feed in feedstuff per ton, within 3 ~ 5 days, is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add gained Chinese medicine microecological preparation 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Embodiment 3
The poultry anti virus herb microbial ecological agent of the present embodiment, is made up of following raw material mixed culture fermentation: Herba Schizonepetae powder 45g, Radix Saposhnikoviae powder 30g, Poria powder 45g, Radix Angelicae Pubescentis powder 25g, Radix Bupleuri powder 30g, front English white 25g, Rhizoma Chuanxiong power 25g, Fructus Aurantii powder 30g, Rhizoma Et Radix Notopterygii powder 25g, balloonflower powder 30g, Herba Menthae powder 15g, Radix Glycyrrhizae powder 15g, Lactobacillus plantarum strain 40mL, Lactobacillus acidophilus species 20mL, bifidobacterium species 40mL, enterococcus faecalis strain 20mL, yeast seeds 30mL, cellulase 10g, phytase 10g, maltose 5g, sodium acetate 2g, potassium dihydrogen phosphate 0.7g.
The poultry anti virus herb microbial ecological agent of the present embodiment, the viable count of described Lactobacillus plantarum strain is 3.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 2.0 × 10
8cFU/mL, bifidobacterium species viable count are 5.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 3.0 × 10
8cFU/mL, yeast seeds viable count are 4.5 × 10
8cFU/mL.
The poultry preparation method of anti virus herb microbial ecological agent of the present embodiment, loads hermetic container after comprising the raw material mix homogeneously getting formula ratio, after 35 DEG C of fermentation 120h, dries and obtain poultry anti virus herb microbial ecological agent for 40 DEG C.
The usage of the poultry anti virus herb microbial ecological agent of the present embodiment is: during treatment, adds gained Chinese medicine microecological preparation 4000 grams and throw something and feed in feedstuff per ton, within 3 ~ 5 days, is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add gained Chinese medicine microecological preparation 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Embodiment 4
The poultry anti virus herb microbial ecological agent of the present embodiment, is made up of following raw material mixed culture fermentation: Herba Schizonepetae powder 50g, Radix Saposhnikoviae powder 35g, Poria powder 40g, Radix Angelicae Pubescentis powder 30g, Radix Bupleuri powder 25g, front English white 25g, Rhizoma Chuanxiong power 30g, Fructus Aurantii powder 35g, Rhizoma Et Radix Notopterygii powder 25g, balloonflower powder 25g, Herba Menthae powder 20g, Radix Glycyrrhizae powder 10g, Lactobacillus plantarum strain 35mL, Lactobacillus acidophilus species 15mL, bifidobacterium species 35mL, enterococcus faecalis strain 30mL, yeast seeds 40mL, fermented cellulosic enzyme 9g, phytase 9g, maltose 7g, sodium acetate 3g, potassium dihydrogen phosphate 0.8g.
The poultry anti virus herb microbial ecological agent of the present embodiment, the viable count of described Lactobacillus plantarum strain is 3.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 2.0 × 10
8cFU/mL, bifidobacterium species viable count are 5.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 2.0 × 10
8cFU/mL, yeast seeds viable count are 3.0 × 10
8cFU/mL.
The poultry preparation method of anti virus herb microbial ecological agent of the present embodiment, loads hermetic container after comprising the raw material mix homogeneously getting formula ratio, after 42 DEG C of fermentation 72h, dries and obtain poultry anti virus herb microbial ecological agent for 50 DEG C.
The usage of the poultry anti virus herb microbial ecological agent of the present embodiment is: during treatment, adds gained Chinese medicine microecological preparation 4000 grams and throw something and feed in feedstuff per ton, within 3 ~ 5 days, is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add gained Chinese medicine microecological preparation 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Embodiment 5
The poultry anti virus herb microbial ecological agent of the present embodiment, is made up of following raw material mixed culture fermentation: Herba Schizonepetae powder 55g, Radix Saposhnikoviae powder 40g, Poria powder 35g, Radix Angelicae Pubescentis powder 35g, Radix Bupleuri powder 20g, front English white 15g, Rhizoma Chuanxiong power 35g, Fructus Aurantii powder 40g, Rhizoma Et Radix Notopterygii powder 15g, balloonflower powder 20g, Herba Menthae powder 25g, Radix Glycyrrhizae powder 5g, Lactobacillus plantarum strain 45mL, Lactobacillus acidophilus species 25mL, bifidobacterium species 35mL, enterococcus faecalis strain 10mL, yeast seeds 20mL, cellulase 12g, phytase 11g, maltose 4g, sodium acetate 1g, potassium dihydrogen phosphate 0.6g.
The poultry anti virus herb microbial ecological agent of the present embodiment, the viable count of described Lactobacillus plantarum strain is 2.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 3.0 × 10
8cFU/mL, bifidobacterium species viable count are 6.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 3.0 × 10
8cFU/mL, yeast seeds viable count are 4.5 × 10
8cFU/mL.
The poultry preparation method of anti virus herb microbial ecological agent of the present embodiment, loads hermetic container after comprising the raw material mix homogeneously getting formula ratio, after 37 DEG C of fermentation 96h, dries and obtain poultry anti virus herb microbial ecological agent for 45 DEG C.。
The usage of the poultry anti virus herb microbial ecological agent of the present embodiment is: during treatment, adds gained Chinese medicine microecological preparation 4000 grams and throw something and feed in feedstuff per ton, within 3 ~ 5 days, is a course for the treatment of, each course for the treatment of 3 days, interval; During prevention, add gained Chinese medicine microecological preparation 2000 grams in feedstuff per ton and throw something and feed, weekly feeding 1 time, each 3 days.
Comparative example
The poultry anti-virus formulation of this comparative example, is made up of the raw material of following parts by weight: 45 parts, Herba Schizonepetae powder, Radix Saposhnikoviae powder 30 parts, Poria powder 45 parts, 25 parts, Radix Angelicae Pubescentis powder, 30 parts, Radix Bupleuri powder, front English white 25 parts, Rhizoma Chuanxiong power 25 parts, 30 parts, Fructus Aurantii powder, 25 parts, Rhizoma Et Radix Notopterygii powder, balloonflower powder 30 parts, Herba Menthae powder 15 parts, Radix Glycyrrhizae powder 15 parts, cellulase 10 parts, phytase 10 parts, maltose 5 parts, sodium acetate 2 parts, potassium dihydrogen phosphate 0.7 part.
Experimental example 1
Jiyuan, Henan pig farm, fatten house swinery sudden onset, in swinery there is symptom in most pig simultaneously, performance anorexia, blunt, exhaustion, roll up, sick pig is crowded together, conjunctival congestion, eye, nose flow out serosity secretions.Swinery bradykinesia, sick pig is reluctant to walk about, and drives also motionless even consumingly.There is rapid and ventral breathing, when particularly forcing disease pig to walk about, more obviously, occurring together serious paroxysmal cough, up to 40.5 ~ 41.7 DEG C, can there is conjunctivitis, rhinitis, nasal secretion and sneeze in body temperature, due to anorexia, sick pig body weight obviously declines, weak.Sick pig is divided into 6 groups at random, and feeding is containing the feedstuff of the Chinese medicine microecological preparation of embodiment 1 ~ 5 successively for experimental group 1 ~ 5, and method is as embodiment 1 ~ 5.Group 6 is matched group, and feeding is containing the feedstuff of comparative example anti-virus formulation, and using method is identical with experimental group 1 ~ 5.
Efficacy assessment standard: cure: piglet searches for food, body temperature, spirit are normal, and respiratory symptom disappears, and weight recovery is normal; Take a turn for the better: respiratory symptom disappears substantially, and temperature recovery is normal; Piglet searches for food, mental status recovers normal substantially; Invalid: not reach improvement target person.
Be used in conjunction 3 days, observe clinical symptoms, the results are shown in Table 1:
Table 1 respectively group efficacy result compares
| Project | Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 4 | Experimental group 5 | Matched group |
| Case load (head) | 128 | 135 | 147 | 130 | 120 | 140 |
| Cure number (head) | 87 | 90 | 102 | 85 | 82 | 85 |
| Good revolution (head) | 32 | 32 | 38 | 34 | 29 | 20 |
| Invalid number (head) | 9 | 13 | 7 | 11 | 9 | 35 |
| Cure rate (%) | 67.97 | 66.67 | 69.39 | 65.38 | 68.33 | 60.71 |
| Improvement rate (%) | 25.0 | 23.70 | 25.85 | 26.15 | 24.17 | 14.29 |
| Effective percentage (%) | 92.97 | 90.37 | 95.24 | 91.53 | 92.50 | 75.00 |
Therapeutic outcome shows, add Chinese medicine microecological preparation of the present invention in feedstuff after, to the treatment of the diseases such as growing and fattening pigs anorexia, not good, the heating of spirit, dyspnea, cough and conjunctivitis, rhinitis and sneeze, there is remarkable result, effective percentage is 90.37%-95.24%, is significantly higher than 75.00% of matched group.Take Chinese medicine microecological preparation of the present invention and do not occur the untoward reaction such as hepatic and renal function injure, show that Chinese medicine microecological preparation of the present invention has good safety.
Experimental example 2
Pig farm, Luohe, Henan Province, carries out ablactational baby pig anorexia, lying on bed for a long time does not rise, generates heat, coughs, the disease prevention experiment such as ventral breathing and respiratory symptom.Experiment pig is divided into 7 groups at random, and feeding is containing the feedstuff of the Chinese medicine microecological preparation of embodiment 1 ~ 5 successively for experimental group 1 ~ 5, and method is as embodiment 1 ~ 5.Group 6 is matched group, and feeding is containing the feedstuff of comparative example anti-virus formulation, and using method is identical with experimental group 1 ~ 5.Group 7 is blank group, and feeding is not containing the feedstuff of any medicine.
Be used in conjunction 3 days, observe clinical symptoms, morbidity piglet head number in January after record wean, the results are shown in Table 2:
Table 2 compares the preventive effect of ablactational baby pig after respectively organizing medication
(note: sickness rate decreasing value be experimental group 1 ~ 5 and matched group respectively with the absolute value of the difference of the sickness rate of blank group)
Prevention result shows, after taking the feedstuff containing Chinese medicine microecological preparation of the present invention, after weaned piglet, anorexia, lying on bed for a long time do not risen, generate heat, cough, the sickness rate of the disease such as ventral breathing and respiratory symptom far below matched group, illustrate that poultry of the present invention fermented type antiviral traditional Chinese medicine has good preventive effect.
Experimental example 3
Zhumadian prefecture, Henan province broiler field, 3 age in days broiler chicken, carry out disease prevention test.Experiment pig is divided into 7 groups at random, and feeding is containing the feedstuff of the Chinese medicine microecological preparation of embodiment 1 ~ 5 successively for experimental group 1 ~ 5, and method is as embodiment 1 ~ 5.Group 6 is matched group, and feeding is containing the feedstuff of comparative example anti-virus formulation, and using method is identical with experimental group 1 ~ 5.Group 7 is blank group, and feeding is not containing the feedstuff of any medicine.
Feeding 1 time weekly, each 3 days, records morbidity broiler quantity in two weeks, the results are shown in Table 3:
Table 3 compares the preventive effect of broiler after respectively organizing medication
(note: sickness rate decreasing value be experimental group 1 ~ 5 and matched group respectively with the absolute value of the difference of blank group sickness rate, mortality rate decreasing value be experimental group 1 ~ 5 and matched group respectively with the absolute value of the difference of blank group mortality rate)
Result shows, compared with blank group, after taking the feedstuff containing Chinese medicine microecological preparation of the present invention, experimental group broiler sickness rate reduces 44 ~ 46%, mortality rate reduces 24 ~ 25.6%, illustrates that Chinese medicine microecological preparation of the present invention has good effect to broiler disease prevention.
Model case 1: broiler field, Heze city of Shandong province, 21 Day-old Broiler Chickens show as spirit depressed, feed intake sharply declines, watery nasal discharge of shedding tears, head enlargement, rapid breathing, cough, sneeze, nasal sinuses swelling, dysentery, part there is death.Main pathology is changed to larynx tracheorrhagia, and nasal sinuses gathers secretions, the pathological change that eye chemosis is hemorrhage.Treat according to the usage of the embodiment of the present invention 2, have positive effect after 2 days, after 5 days, clinical symptoms all disappears.
Model case 2: broiler field, Ruzhou City of Henan Province, morbidity broiler 15 age in days, sickness rate 65%, is mainly respiratory symptom, and rhinorrhea, cough, swelling of the nose is swollen, sneeze, stretch neck and dehisce to breathe, and cockscomb fills, blood inappetence, and drink is for increasing.Cut open inspection and see that nasal sinuses, trachea, air bag, intestinal have some exudative inflammations, sometimes see that air bag has cellulosic to ooze out, cyst wall thickens.Treat according to the usage of the embodiment of the present invention 4, have positive effect after 2 days, after 4 days, clinical symptoms all disappears.
Claims (8)
1. a poultry anti virus herb microbial ecological agent, is characterized in that: the raw material of Chinese medicine mixed culture fermentation primarily of fermented bacterium and following parts by weight is made: Herba Schizonepetae 35 ~ 55 parts, Radix Saposhnikoviae 20 ~ 40 parts, 35 ~ 55 parts, Poria, Radix Angelicae Pubescentis 15 ~ 35 parts, Radix Bupleuri 20 ~ 40 parts, Radix Peucedani 15 ~ 35 parts, Rhizoma Chuanxiong 15 ~ 35 parts, Fructus Aurantii 20 ~ 40 parts, Rhizoma Et Radix Notopterygii 15 ~ 35 parts, Radix Platycodonis 20 ~ 40 parts, Herba Menthae 5 ~ 25 parts, 5 ~ 25 parts, Radix Glycyrrhizae; The consumption of described fermented bacterium is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds Lactobacillus plantarum strain 35 ~ 45mL, Lactobacillus acidophilus species 15 ~ 25mL, bifidobacterium species 35 ~ 45mL, enterococcus faecalis strain 10 ~ 30mL, yeast seeds 20 ~ 40mL.
2. poultry according to claim 1 anti virus herb microbial ecological agent, is characterized in that: be made up of described fermented bacterium, raw material of Chinese medicine and fermenting additive mixed culture fermentation; The consumption of described fermenting additive is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds cellulase 8 ~ 12g, phytase 8 ~ 12g, maltose 3 ~ 8g, sodium acetate 1 ~ 3g, potassium dihydrogen phosphate 0.4 ~ 0.8g.
3. poultry according to claim 1 anti virus herb microbial ecological agent, is characterized in that: the raw material of Chinese medicine mixed culture fermentation primarily of fermented bacterium and following parts by weight is made: Herba Schizonepetae 45 parts, Radix Saposhnikoviae 30 parts, 45 parts, Poria, Radix Angelicae Pubescentis 25 parts, Radix Bupleuri 30 parts, Radix Peucedani 25 parts, Rhizoma Chuanxiong 25 parts, Fructus Aurantii 30 parts, Rhizoma Et Radix Notopterygii 25 parts, Radix Platycodonis 30 parts, Herba Menthae 15 parts, 15 parts, Radix Glycyrrhizae; The consumption of described fermented bacterium is: the Herba Schizonepetae correspondence of every 45g adds Lactobacillus plantarum strain 40mL, Lactobacillus acidophilus species 20mL, bifidobacterium species 40mL, enterococcus faecalis strain 20mL, yeast seeds 30mL.
4. poultry according to claim 3 anti virus herb microbial ecological agent, is characterized in that: be made up of described fermented bacterium, raw material of Chinese medicine and fermenting additive mixed culture fermentation; The consumption of described fermenting additive is: the Herba Schizonepetae correspondence of every 45g adds cellulase 10g, phytase 10g, maltose 5g, sodium acetate 2g, potassium dihydrogen phosphate 0.7g.
5. the anti virus herb microbial ecological agent of the poultry according to any one of claim 1-4, is characterized in that: described Lactobacillus plantarum strain viable count is 1.0 ~ 3.0 × 10
8cFU/mL, Lactobacillus acidophilus species's viable count are 1.0 ~ 3.0 × 10
8cFU/mL, bifidobacterium species viable count are 4.0 ~ 6.0 × 10
8cFU/mL, enterococcus faecalis strain viable count are 2.0 ~ 4.0 × 10
8cFU/mL, yeast seeds viable count are 3.0 ~ 5.0 × 10
8cFU/mL.
6. the poultry as claimed in claim 1 preparation method of anti virus herb microbial ecological agent, it is characterized in that: comprise raw material of Chinese medicine, fermented bacterium and the fermenting additive of getting formula ratio, hermetic container is loaded after mix homogeneously, after 32 ~ 42 DEG C of fermentation 72 ~ 144h, dry and obtain poultry anti virus herb microbial ecological agent.
7. the poultry according to claim 6 preparation method of anti virus herb microbial ecological agent, is characterized in that: described fermenting additive is: cellulase, phytase, maltose, sodium acetate and potassium dihydrogen phosphate; The consumption of fermenting additive is: the Herba Schizonepetae correspondence of every 35 ~ 55g adds cellulase 8 ~ 12g, phytase 8 ~ 12g, maltose 3 ~ 8g, sodium acetate 1 ~ 3g, potassium dihydrogen phosphate 0.4 ~ 0.8g.
8. the poultry according to claim 6 preparation method of anti virus herb microbial ecological agent, is characterized in that: the condition of fermentation is 35 DEG C of fermentation 120h.
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| CN107048389A (en) * | 2017-05-02 | 2017-08-18 | 青岛康迈臣生物科技有限责任公司 | Lung-moistening and throat-clearing food and preparation method |
| CN107349420A (en) * | 2017-06-01 | 2017-11-17 | 烟台民生家禽养殖专业合作社 | A kind of composition, preparation method and application method for being used to prevent and treat contagious catarrh |
| CN108245630A (en) * | 2017-09-30 | 2018-07-06 | 河南牧动物药业有限公司 | For preventing the Chinese medicine composition of pig breeding and respiratory syndrome, fermented type Chinese medicine microecological preparation and its preparation method and application |
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| CN113995788A (en) * | 2020-07-28 | 2022-02-01 | 鲁南制药集团股份有限公司 | Composition for protecting liver and preparation process thereof |
| CN113995788B (en) * | 2020-07-28 | 2023-11-24 | 鲁南制药集团股份有限公司 | Liver protection composition and preparation process thereof |
| CN115671198A (en) * | 2022-11-24 | 2023-02-03 | 河南招财生物工程有限公司 | Antiviral preparation for pigs and preparation method thereof |
| CN115671198B (en) * | 2022-11-24 | 2023-07-14 | 河南招财生物工程有限公司 | An antiviral preparation for pig and its preparation method |
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