CN104127558B - There is the veterinary Chinese medicinal composition of heat-clearing toxin-expelling functions, preparation method and application - Google Patents
There is the veterinary Chinese medicinal composition of heat-clearing toxin-expelling functions, preparation method and application Download PDFInfo
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Abstract
The present invention discloses a kind of veterinary Chinese medicinal composition, preparation method and the application with heat-clearing toxin-expelling functions, belongs to Chinese materia medica for animals and additive for farm animal feed technical field. It is made up of the bulk drug of following weight part number: Japanese Honeysuckle 20��40 parts, the capsule of weeping forsythia 20��40 parts, Radix Rehmanniae 10��20 parts, Tree Peony Bark 10��20 parts, the radix paeoniae rubrathe 10��20 parts, schizonepeta 10��20 parts, peppermint 10��20 parts, windproof 10��20 parts, kuh-seng 20��40 parts, cicada slough 20��40 parts, 10��20 parts, Radix Glycyrrhizae, radix bupleuri 10��20 parts, 15��25 parts, mulberry leaf, chrysanthemum 15��25 parts. Above-mentioned 14 taste Chinese medicines according to monarch principle composition of prescription, Japanese Honeysuckle in side, the capsule of weeping forsythia, schizonepeta, windproof be monarch's medicine, Radix Rehmanniae, Tree Peony Bark, the radix paeoniae rubrathe, kuh-seng, radix bupleuri are ministerial drug, and peppermint, cicada slough, mulberry leaf, chrysanthemum are adjutant, and Radix Glycyrrhizae is for making medicine; All medicines share plays wind and heat dispersing, removing pattogenic heat from the blood and toxic material from the body, reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, purging the lung of pathogenic fire are hot, relieving cough and asthma, Li Shui, the bright order of flat liver, liter lift yang-energy merit altogether.
Description
Technical field
The present invention is specifically related to a kind of veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions, also relates to the preparation method of this Chinese medicine composition and the application in fodder additives simultaneously, belongs to Chinese materia medica for animals and additive for farm animal feed technical field.
Background technology
The anti-removing toxic substances of chaste tree fall apart for " People's Republic of China's veterinary drug allusion quotation " 2010 editions the 2nd announce prescription, by the windproof 15g of schizonepeta 15g, Japanese Honeysuckle 30g, capsule of weeping forsythia 30g, kuh-seng 30g, Radix Rehmanniae 15g, Tree Peony Bark 15g, radix paeoniae rubrathe 15g, peppermint 15g, cicada slough 30g, Radix Glycyrrhizae 15g prescription. In side, kuh-seng and the loose wind of cicada slough are antipruritic, are monarch's medicine; Japanese Honeysuckle and the capsule of weeping forsythia is clearing heat and detoxicating, dispelling wind and heat pathogens is ministerial drug; Schizonepeta, peppermint and windproof dispelling wind and heat pathogens are with antipruritic, and Radix Rehmanniae, the root bark of tree peony and radix paeoniae rubrathe clearing heat and cooling blood, to control blood-head, are adjutant altogether; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription share, and plays the merit of wind and heat dispersing, removing pattogenic heat from the blood and toxic material from the body altogether; Curing mainly maculae caused by violent heat pathogen, blood under intestines heat, conjunctival congestion with pain and swelling of the eye, carbuncle swells sore, wound etc.; Clinical cure mainly blood-head rubella, Huang all over. But, above-mentioned prescription is still not ideal enough in the effect of control livestock and poultry Digestive tract and respiratory system disease.
Summary of the invention
It is an object of the invention to provide a kind of veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions.
Meanwhile, the present invention also provides the preparation method of a kind of veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions.
Moreover, the application also provides the application of a kind of veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions in fodder additives.
In order to realize above object, the technical solution adopted in the present invention is:
A veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions, is made up of the bulk drug of following weight part number: Japanese Honeysuckle 20��40 parts, the capsule of weeping forsythia 20��40 parts, Radix Rehmanniae 10��20 parts, Tree Peony Bark 10��20 parts, the radix paeoniae rubrathe 10��20 parts, schizonepeta 10��20 parts, peppermint 10��20 parts, windproof 10��20 parts, kuh-seng 20��40 parts, cicada slough 20��40 parts, 10��20 parts, Radix Glycyrrhizae, radix bupleuri 10��20 parts, 15��25 parts, mulberry leaf, chrysanthemum 15��25 parts.
Preferably, a kind of veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions, is made up of the bulk drug of following weight part number: Japanese Honeysuckle 30 parts, the capsule of weeping forsythia 30 parts, Radix Rehmanniae 15 parts, Tree Peony Bark 15 parts, the radix paeoniae rubrathe 15 parts, schizonepeta 15 parts, peppermint 15 parts, windproof 15 parts, kuh-seng 30 parts, cicada slough 30 parts, 15 parts, Radix Glycyrrhizae, radix bupleuri 15 parts, 20 parts, mulberry leaf, chrysanthemum 20 parts.
The present invention adopts Japanese Honeysuckle, the capsule of weeping forsythia, Radix Rehmanniae, Tree Peony Bark, the radix paeoniae rubrathe, schizonepeta, peppermint, windproof, kuh-seng, cicada slough, Radix Glycyrrhizae, radix bupleuri, mulberry leaf, chrysanthemum totally ten four taste Chinese medicine, according to monarch principle composition of prescription. Japanese Honeysuckle in side, the capsule of weeping forsythia, schizonepeta, windproof be monarch's medicine, Radix Rehmanniae, Tree Peony Bark, the radix paeoniae rubrathe, kuh-seng, radix bupleuri are ministerial drug, and peppermint, cicada slough, mulberry leaf, chrysanthemum are adjutant, and Radix Glycyrrhizae is for making medicine; All medicines share plays wind and heat dispersing, removing pattogenic heat from the blood and toxic material from the body, reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, purging the lung of pathogenic fire are hot, relieving cough and asthma, Li Shui, the bright order of flat liver, liter lift yang-energy merit altogether.
The summary of each bulk drug effect is as follows:
Japanese Honeysuckle: be the bud of Caprifoliaceae woodbine honeysuckle, Lonicera confusa, wild rice gland honeysuckle, Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms; Containing phenolic acids such as chlorogenic acid, isochlorogenic acid, sterols is such as ��-sitosterol, and volatile oil is such as phantol, ethyl palmitate, ethyl linolenate etc., and flavonoid is such as plurality of active ingredients such as Reseda odorata glycosides, xylostein, Quercetin 3-galactosides; Japanese Honeysuckle nature and flavor are sweet, cold; Attach to the lung and stomach meridians; Can be clearing heat and detoxicating; Curing mainly affection of exogenous wind-heat or warm disease heating, heatstroke, toxic-heat and blood stasis, carbuncle swells furunculosis, larynx numbness, multiple infectious diseases etc.; Modern pharmacology proves that Japanese Honeysuckle has the effects such as resisting pathogenic microbes, inflammation antitoxin, anti-, reducing blood-fat;
The capsule of weeping forsythia: be the fruit of the Oleaceae Forsythia plant capsule of weeping forsythia; Containing lignin compound such as phyllyrin, phyllyrin unit, dextrorotation rosin powder etc., flavonoid compound is such as violaguercitrin, phenylethane analog derivative is such as the capsule of weeping forsythia fat glycosides A, C, D, E, capsule of weeping forsythia kind glycosides etc., cyclohexyl alcohol derivatives is such as bright wood glycosides, capsule of weeping forsythia hexalin etc., triterpene compound, such as Betulinic acid, Oleanolic Acid etc., also contains the plurality of active ingredients such as furans list lactone compound; Capsule of weeping forsythia nature and flavor are bitter, micro-cold, return lung, the heart, gallbladder channel; Clearing heat and detoxicating, the dispersing swelling and dissipating binds of energy; Cure mainly common cold due to wind-heat, warm disease, heat pouring renal shutdown, ulcer, swollen poison, scrofula, goiter and tumor, larynx numbness etc.; Modern pharmacology proves that the capsule of weeping forsythia has antimicrobial, anti-liver injury, suppression phosphodiesterase and lipoxygenase and town and the effect such as tells;
Radix Rehmanniae: be the block root of scrophulariaceae glutinous rehmannia platymiscium glutinous rehmannia; Containing iridoid and glycosides class thereof such as Motherwort Herb glycosides, aucubin, Chinese catalpa alcohol, Martynoside A, B, C, D etc., violet ketoside is such as glutinous rehmannia violet glycosides A, B, C etc., single terpene glycosides glycosides as bitter in glutinous rehmannia, phenylethyl alcohol glucosides is such as Folium Digitalis glycosides C etc., phenylpropyl alcohol glucosides, such as echinacosid etc., also contains JNGZ-B 1-b, lipid acid such as multiple finite element such as TRANSCINNAMIC ACID, lauric acid, tetradecanoic acids; Radix Rehmanniae nature and flavor are sweet, bitter, micro-cold, the thoughts of returning home, liver, kidney channel; Energy removing heat from blood, benefit cloudy blood, promoting blood circulation; Cure mainly warm disease heating, jaundice, haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, hematuria caused by blood-head, have blood in stool, quench one's thirst, hectic fever due to yin labor heat, through closing, puerperal abdonimal pain, numbness impotence, wound etc.; Modern pharmacology proves that Radix Rehmanniae has tumor suppression, anti-inflammation, antimycotic, hypoglycemic, protection effect such as stomach mucous membrane;
Tree Peony Bark: be the root skin of Paeoniaceae Chinese herbaceous peony platymiscium tree peony; Containing iridoid glycoside such as peoniflorin, oxypaeoniflorin, paeonol, the new phenol of tree peony etc., also containing plurality of active ingredients such as gallic acids; Nature and flavor are bitter, pungent, micro-cold, the thoughts of returning home, liver, kidney channel; Energy clearing heat and cooling blood, promoting blood circulation to remove blood stasis; Cure mainly febrile disease pathogenic heat attacking blood system in febrile diseases, send out spot, tell nosebleed, the pyreticosis later stage hot Fu Yin divides heating, hectic fever due to yin hectic fever, amenorrhea due to stagnation of blood, dysmenorrhoea, lump in the abdomen, carbuncle sore tumefacting virus, fall and flutter the pain of injury, beriberoid pyretic arthralgia etc.;Modern pharmacology proves that Tree Peony Bark has anti-inflammation, the effect such as hypoglycemic, and cental system, cardiovascular systems, blood system and immunologic function are produced impact in various degree;
The radix paeoniae rubrathe: be the root of Paeoniaceae Chinese herbaceous peony platymiscium Chinese herbaceous peony, the river radix paeoniae rubrathe; Containing monoterpenes such as radix paeoniae rubrathe glycosides, oxidation radix paeoniae rubrathe glycosides etc., organic acid, such as phenylformic acid, gallic acid etc., also contains the plurality of active ingredients such as catechin, ��-sitosterol; Nature and flavor are bitter, micro-cold, return Liver Channel; Energy clearing heat and cooling blood, row stasis of blood pain relieving, dissipating blood stasis for subsidence of swelling; Curing mainly through closing dysmenorrhoea, hernia lump in the abdomen is gathered, maculae caused by violent heat pathogen, hematemesis and epistaxis, hypochondriac pain due to stagnation of liverQI, discharging fresh blood stool, conjunctival congestion with pain and swelling of the eye, injury from falling down, and carbuncle swellsSore, can be used for through the disease such as closing; Modern pharmacology proves that the radix paeoniae rubrathe has the effects such as antithrombotic, platelet aggregation-against, arteriosclerosis, guarantor liver;
Schizonepeta: be stem leaf and the Hua Sui of Labiatae Schizonepeta tenuifolia platymiscium Schizonepeta tenuifolia and many Schizonepeta tenuifolias; Containing pulegone, piperitone, isomenthone, isopulegone, tens kinds of volatile oil such as neomenthol, menthol, also containing monoterpenes composition such as schizonepeta glycosides A, B, C, D, E, nepetol etc., flavones ingredient is such as diosmetin, Hesperidin, luteolin etc., and liposoluble ingredient is such as plurality of active ingredients such as coffic acid, rosmarinic acid, rosmarinic acid mono-methyls; Schizonepeta nature and flavor hardship pungent, micro-, tepor; Return lung, Liver Channel; Can dispel the wind, induce sweat, promoting eruption, hemostasis; Curing mainly cold, fever, headache, eye itching, cough, swelling and pain in the throat, measles, rubella, carbuncle swells, sore scabies, bleeding from five sense organs or subcutaneous tissue, spits blood, has blood in stool, uterine bleeding, puerperal blood faints etc.; Modern pharmacology proves that schizonepeta has the effects such as antipyretic cooling, calmness, analgesia, anti-inflammation, hemostasis, anti-oxidant, antimicrobial and enhancing body immunologic function;
Peppermint: be full grass or the leaf of Labiatae Mentha plant peppermint; Containing volatile oil such as levorotatory menthol, isomenthol, pulegol etc., 1,2-dihydronaphthalene derivative, ketones component is such as different Rui Fuling, peppermint isoflavone aglycone etc., phenolic acid composition is such as rosmarinic acid, coffic acid etc., and aminoacid component is such as the plurality of active ingredients such as aspartic acid, L-glutamic acid; Peppermint nature and flavor are pungent, cool, return lung, Liver Channel; Energy dispelling wind-heat, the clear profit head, profit pharynx, promoting eruption, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly wind-heat illness that has not attacked the vital organs of the human body, headache hot eyes, swelling and pain in the throat, measles without adequate eruption, rubella itch, hypochondriac pain due to stagnation of liverQI etc.; Modern pharmacology proves that peppermint has spasmolysis, hepatic cholagogic, anti-inflammation, the effect such as antimicrobial, and central nervous system, Digestive tract, respiratory system, cardiovascular systems all have impact in various degree;
Windproof: to be the root that the windproof platymiscium of umbelliferae is windproof; Containing chromone constituents such as windproof chromone alcohol etc., coumarins composition is such as bergmot lactone, psoralene, Phellopterus littoralis element etc., polyacetylene constituents is such as Panaxynol etc., polysaccharide component is such as windproof acidic polysaccharose A, C, volatile oil, such as octanal etc., also contains the plurality of active ingredients such as ��-sitosterol, vanillic acid, wogonin; Windproof nature and flavor are pungent, sweet, tepor, return bladder, lung, the spleen channel; Can dispel the wind induce sweat, removing dampness to relieve pain, only convulsion, antipruritic; Cure mainly catch cold, migraine and general headache, rheumatic arthralgia, stomachache are had loose bowels, discharging fresh blood stool, tetanus, infantile convulsion, kite itch, sore from the beginning of etc.; Modern pharmacology proves windproof to have antipyretic cooling, analgesia, calmness, anti-convulsions, anti-inflammation, the effect such as antibacterial, antitumor;
Kuh-seng: be the root of cassia leguminous plant kuh-seng;Containing alkaloid such as matrine, Oxymatyine etc., flavonoid compound as new in kuh-seng alcohol A, B, C, D, F, G, H, I, J, K, L, M, N, O etc., triterpene saponin is such as Sayasaponin �� etc., and quinones is such as plurality of active ingredients such as kuh-seng quinone A; Kuh-seng nature and flavor are bitter, cold, the thoughts of returning home, lung, kidney, large intestine channel; Energy heat-clearing and damp-drying drug, wind dispelling insecticide; Under curing mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, oedema, band, leprosy, skin pruritus, eczema of lower limb ulcer etc.; Modern pharmacology proves that kuh-seng has the effects such as hepatitis antitumor, anti-and hepatic fibrosis, and cardiovascular systems, central nervous system, immunity system etc. are had regulating effect;
Cicada slough: for cicada section south China grasshopper cicada belong to the black grasshopper of insect sprout wings after cicada shell; Containing effective constituents such as a large amount of chitin, protein, amino acid and organic acids; Nature and flavor are sweet, salty, cool, return lung, Liver Channel; Energy dispelling wind-heat, promoting eruption profit are swallowed, are expellingged wind and relieving convulsion; Cure mainly that common cold due to wind-heat, swelling and pain in the throat, cough sound are mute, measles without adequate eruption, rubella itch, cataract, frightened epilepsy tic, tetanus etc.; Modern pharmacology proves that cicada slough has the effects such as calmness, anti-convulsions, antipyretic, antianaphylaxis and immunosuppression;
Radix Glycyrrhizae: be the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, smooth bark Radix Glycyrrhizae, glycyrrhiza inflate bat; Containing triterpenoid saponin such as glycyrrhizin, Glycyrrhiza uralensis Fisch. saponin A, B etc., flavonoid compound is such as 4',7-Dihydroxyflavanone, liquirtin etc., coumarin kind compound is such as Radix Glycyrrhizae tonka bean camphor, Radix Glycyrrhizae phenol etc., alkaloids is such as quinoline, iloquinoline derivative etc., polysaccharide, such as Radix Glycyrrhizae dextran GBW, licorice polysaccharide UA, UB, UC etc., also contains the plurality of active ingredients such as Radix Glycyrrhizae phenylpropyl alcohol furans, n-tricosane; Radix Glycyrrhizae nature and flavor are sweet, flat, return spleen, stomach, the heart, lung channel; Energy and middle emergency, moistening lung, removing toxic substances, coordinating the actions of various ingredients in a prescription; Process with controlling that weakness of the spleen and the stomach, burnout is eaten less, stomachache loose stool, the anxious pain of four limbs contraction, palpitaition, hysteria, consumptive lung disease cough, raw with controlling swelling and pain in the throat, carbuncle pyogenic infections from tumour or sore, infantile carbuncle and medicine, food poisoning etc.; Modern pharmacology proves that Radix Glycyrrhizae has inflammation antimicrobial, anti-, antibechic, eliminates the phlegm, antitumor, anti-mutation, the effect such as anti-oxidant, and Digestive tract, cardiovascular systems, reproductive system and brain, renal function etc. have regulating effect;
Radix bupleuri: be the root of umbelliferae Bupleunim. L radix bupleuri or Radix Bupeuri Scorzonerfolii.; Containing volatile oil such as o-methoxyphenol, allylguaiacol, cresylol etc., saponin component is such as saikoside a, b2��b3, c etc., flavonoid is such as the plurality of active ingredients such as rutin, Quercetin; Radix bupleuri nature and flavor are bitter, pungent, micro-cold, return liver, gallbladder channel; Can induce sweat bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, liter lift yang-energy; Cure mainly fever caused by exogenous pathogens, alternate attacks of chills and fever, malaria, hypochondriac pain due to stagnation of liverQI breast is swollen, headache is dizzy; Modern pharmacology proves that radix bupleuri has the effects such as anti-inflammation, antitumor, antibacterial, antiviral, antipyretic, calm, analgesia, antibechic, and liver, gi tract, immunologic function, blood fat etc. are had regulating effect;
Mulberry leaf: be the leaf of Sang Ke Mulberry plant mulberry; Containing steroid body and triterpene compound such as Inokosterone, ecdysterone, stigmasterone etc., flavones and glycosides class thereof are such as violaguercitrin, Quercetin etc., tonka bean camphor and glycosides class thereof are such as bergmot lactone, Umbelliferone etc., volatile oil is such as acetic acid, propionic acid, butyric acid etc., amino acid and peptide class are such as L-glutamic acid, aspartic acid, L-Ala etc., alkaloid is if VITAMIN B4, choline etc., organic acid and compound thereof are such as chlorogenic acid, palmitinic acid etc.; Mulberry leaf nature and flavor are bitter, sweet, cold, return lung, Liver Channel; Can dispelling wind and heat pathogens, clearing away lung-heat and moistening dryness, clear liver and improve vision; Cure mainly common cold due to wind-heat, wind-warm syndrome from the beginning of, fever and headache, perspiration and aversion to wind, cough pectoralgia, or dryness of the lung dry cough without phlegm, dry throat are thirsty, wind-heat and liver-yang are disturbed, conjunctival congestion with pain and swelling of the eye etc.; Modern pharmacology proves that mulberry leaf have inflammation hypoglycemic, anti-, increase immunologic function, anti-freezing, the effect such as antibacterial;
Chrysanthemum: be the head inflorescence of composite family chrysanthemum platymiscium chrysanthemum;Containing borneol, camphor, chrysanthemum oil ring ketone, luteolin-7-glucoside, cosmos glycosides, Quercitroside etc., also containing the plurality of active ingredients such as carbohydrate and amino acid; Nature and flavor are sweet, bitter, micro-cold, return lung, Liver Channel; Energy wind and heat dispersing, the bright order of flat liver, detoxify and promote the subsdence of swelling; Cure mainly affection of exogenous wind-heat or wind-heat from the beginning of, fever and headache, dizzy, conjunctival congestion with pain and swelling of the eye, furuncle swelling toxin etc.; Modern pharmacology prove chrysanthemum have antibacterial, antiviral, antitumor, the effect such as delay senility.
A preparation method with the veterinary Chinese medicinal composition of heat-clearing toxin-expelling functions, concrete steps are as follows:
(1) accurately take each bulk drug according to weight part number, pulverize, sieve after mixed even for subsequent use;
(2) be 1:(1��5 according to weight ratio in the mixture of step (1)) add 40��95% ethanolic soln, mixed even rear soaking at room temperature 12��24 hours;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 3��30W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeats 3-5 time;
(4) it is drying to obtain after the medicinal material after radiation treatment in step (3) being reclaimed ethanol.
In described step (2) in immersion treatment process constantly, so that medicinal material complete swelling.
Described step constantly stirs in (3) after each radiation treatment, so that medicinal material is heated evenly.
By medicinal material low temperature Distillation recovery ethanol at 40��50 DEG C in described step (4).
In step (3), microwave power adopts the unit of W/g min, refers to that the wet medicinal material after every gram of imbibition gives the microwave power process of 3-30 watt for every minute.
The application of the veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions in fodder additives, concrete steps are as follows: be 2��300 grams by this Chinese medicine composition according to daily dosage portion and add in animal and fowl fodder.
The useful effect of the present invention:
The veterinary Chinese medicinal composition in the present invention with heat-clearing toxin-expelling functions has the following advantages:
(1) adding the nature and flavor ownership of former prescription, wherein radix bupleuri, chrysanthemum belong to pungent and cold medicine for relieving the exterior syndrome, and mulberry leaf belong to antibechic expectoration medicine;
(2) except the general hot viral disease for the treatment of, simultaneously to chill, common cold due to wind-heat, influenza pestilence, respiratory tract disease such as pneumonia, the equal excellent curative of bronchitis; Alternative Jingfang toxicity-removing falls apart prescription, is that a side is dual-purpose; Depression of liver-QI hepatic diseases also there is fabulous curative effect, to bacterium, viral polyinfection venereal disease example also excellent curative; Three newly-increased taste medicines are the important composition compositions in Sang Ju Yin and Herba Sidae Rhombifoliae soup two prescriptions, therefore the scope of original prescription disease therapy is expanded, turn increase the curative effect of monarch in original prescription, ministerial drug, adjutant is also served good synergy, form a connecting link, making body equilibrium between yin and yang, disease is recovered rapidly;
(3) clinical practice shows to achieve good effect in prophylactic treatment livestock and poultry.
In the present invention, 14 taste Chinese medicines are plant origin, its effective ingredient mainly concentrates in cell, owing to plant cell wall is thicker, most of monogastric animal digestive tube is short, lack again peptidoglycan lytic enzyme, can not be broken its cell walls completely, and its effective ingredient can not discharge, thus has influence on the bioavailability of effective components of Chinese medicinal. Therefore, it may also be useful to being added in feed to prevent and treat livestock and poultry through the simple Chinese medicine pulverized, its Clinical practice effect is not obvious.The present invention utilizes microwave technology process Chinese medicine, take aqueous ethanolic solution as solvent, Chinese medicine fully soaks and makes cell swelling, under microwave high-frequency effect, polar molecule in Chinese medicine cell overturns, and produces heat of friction, causes pressure in cell to raise rapidly, causing cell walls explosion, the effective ingredient in its cell can discharge. Present method does not change the structure of effective ingredient in prescriptions of traditional Chinese medicine, but make its cell wall rupture, discharge in cell and play a role, as peptidoglycan, the cell walls broken as the carrier matrix of effective ingredient, also can promote that in animal body intestinal beneficial bacterium is bred again simultaneously. It is strong that the method has penetration power, and irradiation is even, and a heat is quick, product Energy Consumption Cost is low, production efficiency advantages of higher.
Embodiment
The present invention is only described in further detail by following embodiment, but does not form any limitation of the invention.
Embodiment 1
The veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions is made up of the bulk drug of following weight part number: Japanese Honeysuckle 20 parts, the capsule of weeping forsythia 40 parts, Radix Rehmanniae 20 parts, Tree Peony Bark 10 parts, the radix paeoniae rubrathe 20 parts, schizonepeta 10 parts, peppermint 10 parts, windproof 20 parts, kuh-seng 20 parts, cicada slough 40 parts, 20 parts, Radix Glycyrrhizae, radix bupleuri 10 parts, 15 parts, mulberry leaf, chrysanthemum 25 parts.
The preparation method of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions specifically comprises the following steps:
(1) accurately take each bulk drug according to weight part number, pulverize, fully mixed even for subsequent use after crossing 120 order sieves;
(2) being the ethanolic soln that 1:1 adds 95% according to weight ratio in the mixture of step (1), mixed even rear soaking at room temperature 12 hours, constantly stirs in immersion process, so that medicinal material complete swelling;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 3W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeat 4 times, constantly stir after each radiation treatment, so that medicinal material is heated evenly;
(4) by the low temperature Distillation recovery ethanol at 40 DEG C of the medicinal material after radiation treatment in step (3), then it is dried to moisture content and lower than 10% and get final product.
The application of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions in fodder additives, concrete steps are as follows: be respectively in 200 grams, 40 grams, 40 grams, the 4 grams feeds adding ox, sheep, pig, chicken successively to according to daily dosage portion by the Chinese medicine of above-mentioned preparation.
Embodiment 2
The veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions is made up of the bulk drug of following weight part number: Japanese Honeysuckle 30 parts, the capsule of weeping forsythia 30 parts, Radix Rehmanniae 15 parts, Tree Peony Bark 15 parts, the radix paeoniae rubrathe 15 parts, schizonepeta 15 parts, peppermint 15 parts, windproof 15 parts, kuh-seng 30 parts, cicada slough 30 parts, 15 parts, Radix Glycyrrhizae, radix bupleuri 15 parts, 20 parts, mulberry leaf, chrysanthemum 20 parts.
The preparation method of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions specifically comprises the following steps:
(1) accurately take each bulk drug according to weight part number, pulverize, fully mixed even for subsequent use after crossing 120 order sieves;
(2) being the ethanolic soln that 1:5 adds 75% according to weight ratio in the mixture of step (1), mixed even rear soaking at room temperature 18 hours, constantly stirs in immersion process, so that medicinal material complete swelling;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 18W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeat 4 times, constantly stir after each radiation treatment, so that medicinal material is heated evenly;
(4) by the low temperature Distillation recovery ethanol at 45 DEG C of the medicinal material after radiation treatment in step (3), then it is dried to moisture content and lower than 10% and get final product.
The application of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions in fodder additives, concrete steps are as follows: be respectively in 200 grams, 40 grams, 40 grams, the 4 grams feeds adding ox, sheep, pig, chicken successively to according to daily dosage portion by the Chinese medicine of above-mentioned preparation.
Embodiment 3
The veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions is made up of the bulk drug of following weight part number: Japanese Honeysuckle 40 parts, the capsule of weeping forsythia 40 parts, Radix Rehmanniae 10 parts, Tree Peony Bark 20 parts, the radix paeoniae rubrathe 10 parts, schizonepeta 20 parts, peppermint 20 parts, windproof 10 parts, kuh-seng 40 parts, cicada slough 20 parts, 10 parts, Radix Glycyrrhizae, radix bupleuri 20 parts, 25 parts, mulberry leaf, chrysanthemum 15 parts.
The preparation method of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions specifically comprises the following steps:
(1) accurately take each bulk drug according to weight part number, pulverize, fully mixed even for subsequent use after crossing 120 order sieves;
(2) being the ethanolic soln that 1:3 adds 40% according to weight ratio in the mixture of step (1), mixed even rear soaking at room temperature 24 hours, constantly stirs in immersion process, so that medicinal material complete swelling;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 30W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeat 4 times, constantly stir after each radiation treatment, so that medicinal material is heated evenly;
(4) by the low temperature Distillation recovery ethanol at 50 DEG C of the medicinal material after radiation treatment in step (3), then it is dried to moisture content and lower than 10% and get final product.
The application of the veterinary Chinese medicinal composition in the present embodiment with heat-clearing toxin-expelling functions in fodder additives, concrete steps are as follows: be respectively in 200 grams, 40 grams, 40 grams, the 4 grams feeds adding ox, sheep, pig, chicken successively to according to daily dosage portion by the Chinese medicine of above-mentioned preparation.
Comparative example 1
The anti-removing toxic substances of chaste tree in this comparative example is loose to be made up of the bulk drug of following weight part number: Japanese Honeysuckle 30 parts, the capsule of weeping forsythia 30 parts, Radix Rehmanniae 15 parts, Tree Peony Bark 15 parts, the radix paeoniae rubrathe 15 parts, schizonepeta 15 parts, peppermint 15 parts, windproof 15 parts, kuh-seng 30 parts, cicada slough 30 parts, 15 parts, Radix Glycyrrhizae.
This comparative example specifically comprises the following steps for the preparation method that the anti-removing toxic substances of the chaste tree of livestock and poultry is loose:
(1) accurately take each bulk drug according to weight part number, pulverize, fully mixed even for subsequent use after crossing 120 order sieves;
(2) being the ethanolic soln that 1:5 adds 75% according to weight ratio in the mixture of step (1), mixed even rear soaking at room temperature 18 hours, constantly stirs in immersion process, so that medicinal material complete swelling;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 18W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeat 4 times, constantly stir after each radiation treatment, so that medicinal material is heated evenly;
(4) by the low temperature Distillation recovery ethanol at 45 DEG C of the medicinal material after radiation treatment in step (3), then it is dried to moisture content and lower than 10% and get final product.
The application being dispersed in fodder additives for the anti-removing toxic substances of the chaste tree of livestock and poultry in this comparative example, concrete steps are as follows: be respectively loose for anti-for the chaste tree of above-mentioned preparation removing toxic substances in 200 grams, 40 grams, 40 grams, the 4 grams feeds adding ox, sheep, pig, chicken successively to according to daily dosage portion.
Test example
Experimental animal: test with ox and sheep: by virus or bacteriological infection, or what the factor such as catch cold suddenly caused, there is depression of liver-QI, anorexia, do not ruminate, the cows of the clinical symptom such as eye is crimson and flock of sheep. Test with pig: the swinery of clinical symptom such as occurring that spirit is depressed, lose the appetite, eye of blushing is red, cough is breathed, have loose bowels. Test with chicken: have that spirit is depressed, poor appetite, the hat whisker swollen face of head blue, swollen, expiratory dyspnea, cough, snore, scream, get rid of nose, sneeze, the chicken group of the clinical symptom such as have hemorrhage, green of having loose bowels or yellow-green colour just under hemoptysis, leg scale. Each animal experiment quantity is in table 1.
Test group: test is divided into 5 groups, test is divided into groups according to each colony house actual raising number as a test group (tone group easily causes stress reaction), feed prepared by the edible embodiment 1��3 of test group 1��3 correspondence, control group 1 eats feed prepared by comparative example 1, the edible conventional feed not adding any Chinese medicine of blank group, for eliminating the impact of feed, before adding Chinese medicine, above-mentioned five groups of feeds adopted are identical. Each group experimental animal quantity sees the following form 1.
Test method: start test in each trial flock when there being part individuality that clinical symptom occurs, because modern farming has population characteristic, it is sick that part occurs that namely symptom is considered as whole mass-sending, does not treat for individuality, and using whole group as subjects, test period is 1 month; Experimental animal free choice feeding, drinking-water. Test-results sees the following form 1.
The criterion of clinical prevention effect is as follows:
Cure criterion: clinical symptom disappearance, recover diet wish, it is possible to normally produce;
Effective criterion: part clinical symptom is improved, recovers diet wish, and production restoration is to close to original level;
Effective criterion: part clinical symptom is improved, recovers diet wish, it is possible to produce, but level is general;
Invalid criterion: dead or clinical symptom is not improved;
Curative ratio=(curing number+effective number) �� test sum �� 100%;
Always there is efficiency=(curing number+effective number+significant figure) �� test sum �� 100%.
The result of each treatment group treatment livestock and poultry of table 1
Conclusion: by upper table 1 it will be seen that for test with ruminating animal such as ox, sheep, the curative ratio of test group, always has efficiency to reach 77% and 90%, and control group is only 58% and 82%; For test with pig, the curative ratio of test group, always efficiency is had to reach 74% and more than 91%, and control group is only 61.7 and 85.5%; For test with chicken, the curative ratio of test group, always efficiency is had to reach 84% and more than 94%, and control group is 78.7% and 90%; Visible, test group is better than control group in the curative effect of control livestock and poultry. In whole process of the test, test group and control group all do not find any untoward reaction.
Generally there is the problems such as stocking density is big, the interior Air quality difference of house in modernization breeding scale, in addition cause the cause of disease kind of livestock and poultry complicated, most of case is by caused by the polyinfection of many cause of diseases, therefore, clinical treatment needs consider comprehensive medication, coordinate the prevention effect of science feeding and management can be more remarkable in clinical application.
Claims (6)
1. one kind has the veterinary Chinese medicinal composition of heat-clearing toxin-expelling functions, it is characterised in that: it is made up of the bulk drug of following weight part number: Japanese Honeysuckle 20��40 parts, the capsule of weeping forsythia 20��40 parts, Radix Rehmanniae 10��20 parts, Tree Peony Bark 10��20 parts, the radix paeoniae rubrathe 10��20 parts, schizonepeta 10��20 parts, peppermint 10��20 parts, windproof 10��20 parts, kuh-seng 20��40 parts, cicada slough 20��40 parts, 10��20 parts, Radix Glycyrrhizae, radix bupleuri 10��20 parts, 15��25 parts, mulberry leaf, chrysanthemum 15��25 parts.
2. the veterinary Chinese medicinal composition with heat-clearing toxin-expelling functions according to claim 1, it is characterised in that: it is made up of the bulk drug of following weight part number: Japanese Honeysuckle 30 parts, the capsule of weeping forsythia 30 parts, Radix Rehmanniae 15 parts, Tree Peony Bark 15 parts, the radix paeoniae rubrathe 15 parts, schizonepeta 15 parts, peppermint 15 parts, windproof 15 parts, kuh-seng 30 parts, cicada slough 30 parts, 15 parts, Radix Glycyrrhizae, radix bupleuri 15 parts, 20 parts, mulberry leaf, chrysanthemum 20 parts.
3. one kind adopts the method that veterinary Chinese medicinal composition as claimed in claim 1 or 2 prepares Chinese medicine, it is characterised in that: concrete steps are as follows:
(1) accurately take each bulk drug according to weight part number, pulverize, sieve after mixed even for subsequent use;
(2) be 1:(1��5 according to weight ratio in the mixture of step (1)) add 40��95% ethanolic soln, mixed even rear soaking at room temperature 12��24 hours;
(3) ethanolic soln not absorbed in filtering step (2), medicinal material after filtering is carried out radiation treatment with the microwave power of 3��30W/g min, it is 80 DEG C of stoppings to temperature, it is down to 60��70 DEG C when temperature and repeats radiation treatment by above-mentioned power, it is 80 DEG C of stoppings to temperature, so repeats 3-5 time;
(4) it is drying to obtain after the medicinal material after radiation treatment in step (3) being reclaimed ethanol.
4. method according to claim 3, it is characterised in that: described step constantly stirs in (2) in immersion treatment process.
5. method according to claim 3, it is characterised in that: described step constantly stirs in (3) after each radiation treatment.
6. method according to claim 3, it is characterised in that: by medicinal material low temperature Distillation recovery ethanol at 40��50 DEG C in described step (4).
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| CN105851569A (en) * | 2016-04-19 | 2016-08-17 | 周清 | Live pig summer heat avoiding feed |
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| CN114642709B (en) * | 2022-03-29 | 2023-03-03 | 四川农业大学 | Traditional Chinese medicine composition and extract for improving reproductive performance of later laying period of breeding hens and preparation method thereof |
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| CN1781522A (en) * | 2004-11-30 | 2006-06-07 | 王丙尧 | Chinese medicine composition for treating avian flu |
| CN101019939A (en) * | 2007-03-23 | 2007-08-22 | 李懋洲 | Acne treating medicine composition |
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| CN1733182A (en) * | 2005-08-17 | 2006-02-15 | 江苏济川制药有限公司 | Medicine composition for curing exogenous fever and process for preparing the same |
| CN101019939A (en) * | 2007-03-23 | 2007-08-22 | 李懋洲 | Acne treating medicine composition |
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