CN104127551B - A kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition and preparation method and application - Google Patents
A kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition and preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition and preparation method and application, belong to Chinese medicine for animals and additive for farm animal feed technical field.This Chinese medicine composition is made up of the crude drug of following parts by weight: Rhizoma Coptidis 20 ~ 40 parts, Radix Scutellariae 50 ~ 70 parts, Cortex Phellodendri 50 ~ 70 parts, Fructus Gardeniae 35 ~ 55 parts, Flos Lonicerae 40 ~ 60 parts, Radix Isatidis 50 ~ 70 parts, the Radix Pulsatillae 10 ~ 30 parts.Above-mentioned seven taste Chinese medicines are according to monarch principle composition of prescription, in side, Rhizoma Coptidis, Radix Isatidis are monarch drug, Radix Scutellariae, Flos Lonicerae are ministerial drug, Cortex Phellodendri, the Radix Pulsatillae are adjuvant drug, Fructus Gardeniae is for making medicine, all medicines share the merit of playing eliminating fire and detoxication, clearing away heat and cooling blood, treatment enteritis and dysentery altogether, cure mainly excessive heat in SAN JIAO, skin ulcer general edema with yellowish skin poison, pestilence, pyretic toxicity sore throat, dysentery enteritis, the febrile disease etc. that caused by bacterial virus mixed infection.
Description
Technical field
The present invention is specifically related to a kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition, also relates to the preparation method of this Chinese medicine composition and the application in feed additive simultaneously, belongs to Chinese medicine for animals and additive for farm animal feed technical field.
Background technology
Huanglian Jiedusan is the prescription that " People's Republic of China's veterinary drug allusion quotation " 2010 editions second is announced, by Rhizoma Coptidis 30g, Radix Scutellariae 60g, Cortex Phellodendri 60g, Fructus Gardeniae 45g prescription.In side, Rhizoma Coptidis rushes down that part of the body cavity above the diaphragm housing the heart and lungs heart-fire is double rushes down moderate heat, is monarch drug; Radix Scutellariae rushes down part of the body cavity above the diaphragm housing the heart and lungs lung-fire, is ministerial drug; Huang Bo rushes down kidney of lower warmer fire, is adjuvant drug; The logical fire rushing down three Jiao of Fructus Gardeniae, heat conduction is descending to go out from bladder, for making medicine.All medicines share, and play the merit of eliminating fire and detoxication altogether; Clinically cure mainly excessive heat in SAN JIAO, skin ulcer general edema with yellowish skin poison; Be used for the treatment of the diseases such as septicemia, pyemia, dysentery and pneumonia.
Huanglian Jiedusan can think " formulation of three-yellow decoction "-Radix Et Rhizoma Rhei, Rhizoma Coptidis, Radix Scutellariae from prescription composition angle, removes Radix Et Rhizoma Rhei, adds Cortex Phellodendri, prescription that Fructus Gardeniae two taste Chinese medicine forms, is anti-inflammation side; Also can be regarded as " in Treatise on Febrile Diseases Radix Pulsatillae Decoction "-Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, is clearing away damp-heat dysentery relieving side, removes the Radix Pulsatillae, Cortex Fraxini two taste Chinese medicine adds Radix Scutellariae, Fructus Gardeniae forms prescription.From original prescription four taste Chinese medicine nature and flavor ownership, Fructus Gardeniae ownership heat clearing and fire purging medicine, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri belong to heat clearing and dampness removing medicine.And heat clearing away class medicine divides four classes in Chinese medicine rationale: heat clearing and fire purging medicine, the dry light medicine of heat clearing away, heat removing and blood cooling medicine, heat and toxic materials clearing away medicine.And only account for two classes in original prescription.Can say that the pathogenic fire purging of original prescription Huanglian Jiedusan is prosperous and powerful, but disease-resistant virulence is not enough.
Summary of the invention
The object of this invention is to provide a kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition.
Meanwhile, the present invention also provides the preparation method of a kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition.
Moreover the present invention also provides a kind of heat-clearing and toxic substances removing, the application of antiviral veterinary Chinese medicinal composition in feed additive.
In order to realize above object, the technical solution adopted in the present invention is:
A kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition, be made up of the crude drug of following parts by weight: Rhizoma Coptidis 20 ~ 40 parts, Radix Scutellariae 50 ~ 70 parts, Cortex Phellodendri 50 ~ 70 parts, Fructus Gardeniae 35 ~ 55 parts, Flos Lonicerae 40 ~ 60 parts, Radix Isatidis 50 ~ 70 parts, the Radix Pulsatillae 10 ~ 30 parts.
Preferably, a kind of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition, be made up of the crude drug of following parts by weight: Rhizoma Coptidis 30 parts, Radix Scutellariae 60 parts, Cortex Phellodendri 60 parts, Fructus Gardeniae 45 parts, Flos Lonicerae 50 parts, Radix Isatidis 60 parts, the Radix Pulsatillae 20 parts.
The present invention adopts Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Flos Lonicerae, Radix Isatidis, the Radix Pulsatillae totally seven taste Chinese medicines, according to monarch principle composition of prescription, there is effect of eliminating fire and detoxication, clearing away heat and cooling blood, treatment enteritis and dysentery, cure mainly excessive heat in SAN JIAO, skin ulcer general edema with yellowish skin poison, pestilence, pyretic toxicity sore throat, dysentery enteritis, the febrile disease etc. that caused by bacterial virus mixed infection.Wherein, Rhizoma Coptidis, Radix Isatidis are monarch drug, and Radix Scutellariae, Flos Lonicerae are ministerial drug, and Cortex Phellodendri, the Radix Pulsatillae are adjuvant drug, and Fructus Gardeniae is for making medicine.
Each crude drug effect is summarized as follows:
Rhizoma Coptidis: be the rhizome of Ranunculaceae coptis plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis teeta; Containing alkaloids as plurality of active ingredients such as berberine, coptisine, epiberberine, obacunone; Nature and flavor are bitter, cold, GUIXIN, liver, stomach, large intestine channel; Energy clearing away heat-fire, dampness, removing toxic substances; Cure mainly calentura heresy and enter the high heat of heart channel, the telling nosebleed, the damp and hot feeling of stuffiness in chest, have loose bowels of irritated, delirium or the absurd shape of intenseness of heat forcing blood, the vexed insomnia of dysentery, hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue etc.; Modern pharmacology proves that Rhizoma Coptidis has the effects such as antimicrobial, disease-resistant protozoon, antiviral, arrhythmia, antiulcer, antitumor, antiinflammatory;
Radix Scutellariae: be the root of Labiatae Scutellaria plant Radix Scutellariae; Containing flavone compound as baicalin, neobaicalein, baicalin, wogonoside etc., also containing plurality of active ingredients such as cupreol, campesterol and stigmasterol; Nature and flavor are bitter, cold, return lung, the heart, liver, gallbladder, large intestine channel; Can clearing away heat-fire, dampness removing toxic substances, hemostasis, antiabortive; Cure mainly lung-heat cough with asthma, calentura unconsciousness due to high fever, liver-fire headache, conjunctival congestion and swelling pain, jaundice due to damp-heat, dysentery, pyretic stranguria, tell nosebleed, excessive fetal movement due to heat in pregnancy, carbuncle furuncle etc.; Modern pharmacology prove Radix Scutellariae have antimicrobial, antiplatelet aggregation and anticoagulant, antioxidation, anticancer, reduce blood pressure and the effect such as diuresis, blood fat reducing;
Cortex Phellodendri: be the bark of Rutaceae Phellodendron plant wampee or Cortex Phellodendri; Containing alkaloids as berberine, phellodendrine, magnoflorine, jateorhizine etc., also containing plurality of active ingredients such as limonin, obacunone, campesterol, stigmasterol; Nature and flavor are bitter, cold, return kidney, bladder, large intestine channel; Energy heat clearing and damp drying, eliminating fire and detoxication; Cure mainly hygropyretic dysentery, have loose bowels, jaundice, hectic fever due to YIN-deficiency consumptive fever, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore etc.; Modern pharmacology proves that Cortex Phellodendri has resisting pathogenic microbes, antipyretic and effect such as anti-inflammatory, antiplatelet aggregation, has facilitation to cardiovascular system, digestive system and central nervous system;
Fructus Gardeniae: be the fruit of Rubiaceae Gardenia Ellis plant Fructus Gardeniae; Containing iridoids as jasminoidin, Fructus Gardeniae glycosides, Fructus Gardeniae ketoside etc., phenolic acids is as chlorogenic acid etc., and carotenoid, as crocin, crocetin etc., also contains the plurality of active ingredients such as rutin, ursolic acid; Nature and flavor are bitter, cold, GUIXIN, liver, lung, stomach, tri-jiao channel; Energy pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Cure mainly that calentura is vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, haematemesis, epistaxis, dysentery, hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprain and swell and ache; Modern pharmacology proves that Fructus Gardeniae has the effects such as antibacterial, antiinflammatory, has facilitation to digestive system, central nervous system cardiovascular system of unifying;
Flos Lonicerae: be the alabastrum of Caprifoliaceae woodbine Radix Ophiopogonis, Lonicera confusa, wild rice gland Radix Ophiopogonis, Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms; Containing phenolic acids as chlorogenic acid, isochlorogenic acid, sterols is as cupreol, and volatile oil is as linalool, ethyl palmitate, ethyl linolenate etc., and flavonoid is as plurality of active ingredients such as luteoloside, xylostein, hyperins; Flos Lonicerae nature and flavor are sweet, cold; Attach to the lung and stomach meridians; Energy heat-clearing and toxic substances removing; Cure mainly affection due to external wind and heat or epidemic febrile disease heating, heatstroke, toxic-heat and blood stasis, carbuncle furuncle, sore throat, multi-infection disease etc.; Modern pharmacology proves that Flos Lonicerae has the effects such as resisting pathogenic microbes, antitoxin, antiinflammatory, blood fat reducing; Especially stronger antibacterial action is had to dysentery bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus etc.;
Radix Isatidis: be the root of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.; Containing indigo, indirubin and several amino acids, as arginine, glutamic acid etc., also containing plurality of active ingredients such as sinigrin, indigo glycosides, couroupitine As; Radix Isatidis nature and flavor are bitter, cold, GUIXIN, lung.Liver, stomach warp; Energy heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving; Cure mainly anemopyretic cold, influenza, epidemic encephalitis, encephalitis b, major part pestilence, the diseases such as scarlet fever; Modern pharmacology proves that Radix Isatidis has antibacterium, antiviral, antiendotoxin, the effect such as anticancer, has regulating action to immune system simultaneously; Research shows that Radix Isatidis is to G
+and G
-bacterium all has inhibitory action, in control encephalitis b, parotitis, have good therapeutic effect;
The Radix Pulsatillae: be the root of the Ranunculaceae Pulsatilla plant Radix Pulsatillae; Containing triterpenoid as the plurality of active ingredients such as Anemonin, betulic acid, 3-oxo fat acid, Pulsatilla saponin A, B, C, D; Nature and flavor are bitter, cold, return stomach, large intestine channel; Energy heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; Cure mainly dysentery, epistaxis, internal hemorrhoid with bleeding, cold and heat pyrexial malaria, scrofula, eczema carbuncle skin ulcer, eyes swelling pain etc.; Modern pharmacology proves that the Radix Pulsatillae has resisting pathogenic microbes, anti-ameba, other pathogen anti-, antitumor, antiinflammatory and strengthens the effects such as immunologic function; Dermatophytes and bacillus pyocyaneus can be suppressed, have the cardiotonic of similar Folium Digitalis Purpureae simultaneously.
A preparation method for heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition, concrete steps are as follows:
(1) accurately take each crude drug according to parts by weight, pulverize, sieve after mix for subsequent use;
(2) be 1:(1 ~ 5 according to weight ratio in the mixture of step (1)) add 40 ~ 95% alcoholic solution, soaking at room temperature 12 ~ 24 hours after mixing;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 3 ~ 30W/gmin, is 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, so repeat 3-5 time;
(4) be drying to obtain after the medical material after radiation treatment in step (3) being reclaimed ethanol.
Described step constantly stirs in (2) in immersion treatment process, to make medical material complete swelling.
Described step constantly stirs in (3) after each radiation treatment, is heated evenly to make medical material.
By medical material low temperature Distillation recovery ethanol at 40 ~ 50 DEG C in described step (4).
In step (3), microwave power adopts the unit of W/gmin, refers to the microwave power process giving 3-30 watt per minute of the wet medical material after every gram of imbibition.
Heat-clearing and toxic substances removing, the application of antiviral veterinary Chinese medicinal composition in feed additive, concrete steps are as follows: Chinese medicine composition is 1 ~ 250 gram according to consumption per day and adds in animal and fowl fodder.
Beneficial effect of the present invention:
In the present invention, heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition have the following advantages:
(1) both maintain effect of original prescription pathogenic fire purging power prosperity, overcome again the defect of its anti-virus ability deficiency; Novel composing prescription Chinese medicine is except the effect possessing eliminating fire and detoxication, also possess heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, removing toxic substances heat radiation, clearing away heat and cooling blood, resolving toxin and disinhibiting the throat, the poison of solution pestilence sore throat, eliminating pathogenic heat from blood to cure dysentery, removing toxic substances control the effects such as dysentery, cure mainly excessive heat in SAN JIAO, skin ulcer general edema with yellowish skin poison, pestilence, pyretic toxicity sore throat, dysentery enteritis, the febrile disease etc. that caused by bacterial virus mixed infection;
(2) novel composing prescription Chinese medicine is not only applicable to three burnt intenseness of heat clinically, dry mad, the dryness of the mouth and throat that generates heat, sends out speckle and tell the strong case of nosebleed, carbuncle furunculosis, red tongue with yellow fur, rapid pulse, antibacterial, virus mixed infection, pestilence, sore throat case, pyretic toxicity are got deeply stuck in simultaneously, blood system dysentery, pus and blood, tenesmus, have heating etc. concurrently and all reach fabulous therapeutic effect;
(3) clinical practice shows to achieve good effect in prophylactic treatment livestock and poultry.
In the present invention, seven taste Chinese medicines are plant origin, its active ingredient mainly concentrates in cell, because plant cell wall is thicker, most of nonruminant digestive tract is short, lack Peptidoglycan catabolic enzyme again, can not be broken its cell wall completely, and its active ingredient can not discharge, thus has influence on the bioavailability of effective components of Chinese medicinal.Therefore, use the Chinese medicine through simple pulverizing to be added in feedstuff and prevent and treat livestock and poultry, its Clinical practice DeGrain.The present invention utilizes microwave technology process Chinese medicine composition, take ethanol water as solvent, Chinese medicine fully soaks and makes cell swelling, under microwave high-frequency effect, the intracellular polar molecule of Chinese medicine overturns, and produces frictional heat, causes ICP to raise rapidly, cause cell wall explosion, its intracellular active ingredient can discharge.This method does not change the structure of active ingredient in prescriptions of Chinese medicine, but make its cell wall rupture, discharge in cell and play a role, as Peptidoglycan, the cell wall broken as the carrier matrix of active ingredient, also can promote that intestinal beneficial bacterium is bred again simultaneously in animal body.It is strong that the method has penetration power, uniform irradiation, and a heat is quick, product Energy Consumption Cost is low, production efficiency advantages of higher.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
In the present embodiment, heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition are made up of the crude drug of following parts by weight: Rhizoma Coptidis 20 parts, Radix Scutellariae 50 parts, Cortex Phellodendri 70 parts, Fructus Gardeniae 35 parts, Flos Lonicerae 60 parts, Radix Isatidis 70 parts, the Radix Pulsatillae 10 parts.
In the present embodiment, the preparation method of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition specifically comprises the following steps:
(1) accurately take each crude drug according to parts by weight, pulverize, fully mix for subsequent use after crossing 60 mesh sieves;
(2) be the alcoholic solution that 1:2 adds 60% according to weight ratio in the mixture of step (1), after mixing, soaking at room temperature 18 hours, constantly stirs in immersion process, to make medical material complete swelling;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 20W/gmin, be 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, repetition like this 4 times, constantly stirs after each radiation treatment, is heated evenly to make medical material;
(4) by the medical material low temperature Distillation recovery ethanol at 40 DEG C after radiation treatment in step (3), moisture is then dried to lower than 10% and get final product.
Heat-clearing and toxic substances removing, the application of antiviral veterinary Chinese medicinal composition in feed additive in the present embodiment, concrete steps are as follows: the Chinese medicine of above-mentioned preparation is respectively 180 grams, 35 grams, 35 grams, 3 grams according to consumption per day and adds to successively in the feedstuff of cattle, sheep, pig, chicken.
Embodiment 2
In the present embodiment, heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition are made up of the crude drug of following parts by weight: Rhizoma Coptidis 30 parts, Radix Scutellariae 60 parts, Cortex Phellodendri 60 parts, Fructus Gardeniae 45 parts, Flos Lonicerae 50 parts, Radix Isatidis 60 parts, the Radix Pulsatillae 20 parts.
In the present embodiment, the preparation method of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition specifically comprises the following steps:
(1) accurately take each crude drug according to parts by weight, pulverize, fully mix for subsequent use after crossing 120 mesh sieves;
(2) be the alcoholic solution that 1:5 adds 40% according to weight ratio in the mixture of step (1), after mixing, soaking at room temperature 24 hours, constantly stirs in immersion process, to make medical material complete swelling;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 3W/gmin, be 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, repetition like this 3 times, constantly stirs after each radiation treatment, is heated evenly to make medical material;
(4) by the medical material low temperature Distillation recovery ethanol at 50 DEG C after radiation treatment in step (3), moisture is then dried to lower than 10% and get final product.
Heat-clearing and toxic substances removing, the application of antiviral veterinary Chinese medicinal composition in feed additive in the present embodiment, concrete steps are as follows: the Chinese medicine of above-mentioned preparation is respectively 180 grams, 35 grams, 35 grams, 3 grams according to consumption per day and adds to successively in the feedstuff of cattle, sheep, pig, chicken.
Embodiment 3
In the present embodiment, heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition are made up of the crude drug of following parts by weight: Rhizoma Coptidis 40 parts, Radix Scutellariae 70 parts, Cortex Phellodendri 50 parts, Fructus Gardeniae 55 parts, Flos Lonicerae 40 parts, Radix Isatidis 50 parts, the Radix Pulsatillae 30 parts.
In the present embodiment, the preparation method of heat-clearing and toxic substances removing, antiviral veterinary Chinese medicinal composition specifically comprises the following steps:
(1) accurately take each crude drug according to parts by weight, pulverize, fully mix for subsequent use after crossing 80 mesh sieves;
(2) be the alcoholic solution that 1:1 adds 95% according to weight ratio in the mixture of step (1), after mixing, soaking at room temperature 12 hours, constantly stirs in immersion process, to make medical material complete swelling;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 30W/gmin, be 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, repetition like this 5 times, constantly stirs after each radiation treatment, is heated evenly to make medical material;
(4) by the medical material low temperature Distillation recovery ethanol at 45 DEG C after radiation treatment in step (3), moisture is then dried to lower than 10% and get final product.
Heat-clearing and toxic substances removing, the application of antiviral veterinary Chinese medicinal composition in feed additive in the present embodiment, concrete steps are as follows: the Chinese medicine of above-mentioned preparation is respectively 180 grams, 35 grams, 35 grams, 3 grams according to consumption per day and adds to successively in the feedstuff of cattle, sheep, pig, chicken.
Comparative example 1
Huanglian Jiedusan in this comparative example is made up of the crude drug of following parts by weight: Rhizoma Coptidis 30 parts, Radix Scutellariae 60 parts, Cortex Phellodendri 60 parts, Fructus Gardeniae 45 parts.
The preparation method of the Huanglian Jiedusan in this comparative example specifically comprises the following steps:
(1) accurately take each crude drug according to parts by weight, pulverize, fully mix for subsequent use after crossing 120 mesh sieves;
(2) be the alcoholic solution that 1:5 adds 40% according to weight ratio in the mixture of step (1), after mixing, soaking at room temperature 24 hours, constantly stirs in immersion process, to make medical material complete swelling;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 3W/gmin, be 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, repetition like this 3 times, constantly stirs after each radiation treatment, is heated evenly to make medical material;
(4) by the medical material low temperature Distillation recovery ethanol at 50 DEG C after radiation treatment in step (3), moisture is then dried to lower than 10% and get final product.
Coptis detoxifcation in this comparative example is dispersed in the application in feed additive, and concrete steps are as follows: the Chinese medicine of above-mentioned preparation is respectively 180 grams, 35 grams, 35 grams, 3 grams according to consumption per day and adds to successively in the feedstuff of cattle, sheep, pig, chicken.
Test example
Experimental animal: test is with cattle and sheep: caused by factors such as viral or bacteriological infection, the cows of three burnt intenseness of heat, the generate heat clinical symptoms such as dry mad, dryness of the mouth and throat, constipation with dry stool and flock of sheep.Test is with pig: occur that spirit is depressed, blush eye red, cough and to breathe, draw the swinery of the clinical symptoms such as excrement ball.Test is with chicken: have that spirit is depressed, inappetence, feather dry up, be preced with that whisker is blue, dyspnea, cough, scream, the chicken group of sneeze, the clinical symptoms such as draw green just.Each animal experiment quantity sees the following form 1.
Test group: test is divided into 5 groups, test is divided into groups according to each colony house actual raising number as a test group (tone group easily causes stress), feedstuff prepared by the edible embodiment 1 ~ 3 of test group 1 ~ 3 correspondence, matched group 1 eats feedstuff prepared by comparative example 1, blank group eats the conventional feedstuff not adding any Chinese medicine, for eliminating the impact of feedstuff, before adding Chinese medicine, above-mentioned five groups of feedstuffs adopted are identical.Each group experimental animal quantity sees the following form 1.
Test method: start test in each trial flock when there being some individuals to occur clinical symptoms, because modern farming has population characteristic, part occurs that namely symptom is considered as cluster morbidity, does not treat for individuality, and using cluster as subjects, test period is 1 month; Experimental animal free choice feeding, drinking-water.Result of the test sees the following form 1.
The criterion of clinical prevention effect is as follows:
Cure criterion: clinical symptom disappearance, recover diet wish, can normally produce;
Effective criterion: partial clinical symptom is improved, recovers diet wish, and production restoration is to close to original level;
Effective criterion: partial clinical symptom is improved, recovers diet wish, can produce, but level is general, finally eliminates;
Invalid criterion: dead or clinical symptoms is not improved;
Cure rate=(curing number+effective number) ÷ test sum × 100%;
Total effective rate=(curing number+effective number+significant figure) ÷ test sum × 100%.
The result of table 1 each processed group treatment livestock and poultry
Conclusion: from upper table 1, at the different poultry anemopyretic cold of control and by virus, the disease that causes of bacteria mixed infection, the cure rate of test group, total effective rate are all 70%, more than 90%, and matched group is only 60% and about 80%; In whole process of the test, test group and matched group all do not find any untoward reaction.
The problems such as modernization breeding scale ubiquity stocking density is large, the interior air quality difference of house, in addition cause the cause of disease kind of livestock and poultry complicated, most of case is caused by cause of disease mixed infection, therefore, clinical treatment needs consider comprehensive medication, and though the Chinese medicine of comparative example 1 can be used for heat-clearing and toxic substances removing, anti-virus ability is not enough, and its curative effect of case of preventing and treating multiple cause of disease mixed infection is clinically slightly inadequate.In clinical practice, coordinate the prevention effect of science feeding and management can be more remarkable.
Claims (6)
1. heat-clearing and toxic substances removing, an antiviral veterinary Chinese medicinal composition, is characterized in that: be made up of the crude drug of following parts by weight: Rhizoma Coptidis 20 ~ 40 parts, Radix Scutellariae 50 ~ 70 parts, Cortex Phellodendri 50 ~ 70 parts, Fructus Gardeniae 35 ~ 55 parts, Flos Lonicerae 40 ~ 60 parts, Radix Isatidis 50 ~ 70 parts, the Radix Pulsatillae 10 ~ 30 parts.
2. heat-clearing and toxic substances removing according to claim 1, antiviral veterinary Chinese medicinal composition, is characterized in that: be made up of the crude drug of following parts by weight: Rhizoma Coptidis 30 parts, Radix Scutellariae 60 parts, Cortex Phellodendri 60 parts, Fructus Gardeniae 45 parts, Flos Lonicerae 50 parts, Radix Isatidis 60 parts, the Radix Pulsatillae 20 parts.
3. adopt veterinary Chinese medicinal composition as claimed in claim 1 or 2 to prepare a method for Chinese medicine, it is characterized in that: concrete steps are as follows:
(1) accurately take each crude drug according to parts by weight, pulverize, sieve after mix for subsequent use;
(2) be 1:(1 ~ 5 according to weight ratio in the mixture of step (1)) add 40 ~ 95% alcoholic solution, soaking at room temperature 12 ~ 24 hours after mixing;
(3) unabsorbed alcoholic solution in filtering step (2), medical material after filtering is carried out radiation treatment with the microwave power of 3 ~ 30W/gmin, is 80 DEG C of stoppings to temperature, when temperature is down to 60 ~ 70 DEG C by the process of above-mentioned power repetitive irradiation, be 80 DEG C of stoppings to temperature, so repeat 3-5 time;
(4) be drying to obtain after the medical material after radiation treatment in step (3) being reclaimed ethanol.
4. method according to claim 3, is characterized in that: described step constantly stirs in (2) in immersion treatment process.
5. method according to claim 3, is characterized in that: described step constantly stirs in (3) after each radiation treatment.
6. method according to claim 3, is characterized in that: by medical material low temperature Distillation recovery ethanol at 40 ~ 50 DEG C in described step (4).
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| CN107375753A (en) * | 2017-08-14 | 2017-11-24 | 宜宾五尺道集团有限公司 | A kind of autumn and winter market pig health care preparation and application |
| CN107468796A (en) * | 2017-08-22 | 2017-12-15 | 武汉新联大生物有限公司 | A kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition and preparation method |
| CN110101762B (en) * | 2019-06-13 | 2021-05-11 | 山东畜牧兽医职业学院 | Traditional Chinese medicine composition for treating damp-heat diarrhea of poultry and preparation method thereof |
| CN111265534A (en) * | 2020-03-19 | 2020-06-12 | 广西馨海药业科技有限公司 | Application of pulsatilla chinensis saponin B4 in preparation of medicines for treating/preventing sepsis |
| CN112587636A (en) * | 2020-12-28 | 2021-04-02 | 江西嘉博生物工程有限公司 | Antiviral particle and preparation method thereof |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
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