CN103054985B - Pure Chinese medicinal composition for treating red fin disease of eels and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating red fin disease of eels and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the red fin disease of eels. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 25 to 45 parts of houttuynia cordata, 15 to 40 parts of Chinese knotweed herb, 15 to 35 parts of red-knees herb, 15 to 35 parts of licorice root, 15 to 35 parts of indigowoad root, 15 to 35 parts of hedyotis diffusa, 10 to 20 parts of salt, 20 to 40 parts of dried orange peel, 20 to 40 parts of plantain herb and 20 to 40 parts of lonicera japonica. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the red fin disease of the eels.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of Anguillar japonica red fin fish disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment Anguillar japonica red fin fish disease and preparation method thereof.
Background technology
Anguillar japonica red fin fish disease is that caused by Aeromonas hydrophila a kind of has that spread speed is fast, relapse rate is high, and the easy deadly infectious disease of other bacterial disease of secondary.Sick eel anal fin, pectoral fin are rubescent, and the veutro skin of trunk and head has hemorrhage and ecchymosis, and when serious, above-mentioned position is all rubescent, and even trunk back and dorsal fin also take on a red color.Sick eel does not eat food, and near pool wall transfixion, some heads upwards, " erect trip " feebly, most dead in several days.The sick eel intestinal of anatomic observation is congested, rubescent, and liver congestion is kermesinus, kidney enlargement.This disease causes serious economic loss to eel fish culture.
This disease almost spreads all over the world all eel cultures country, is widely distributed.Primary disease western medicine is mainly used antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, particle diameter is excessive, and drug release is slower, causes its bioavailability lower, and clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of Anguillar japonica red fin fish disease, micronizing, bioavailability are high, and the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, micronizing, bioavailability are high, treating both the principal and secondary aspects of a disease, pure Chinese medicine composition of effective treatment Anguillar japonica red fin fish disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Anguillar japonica red fin fish disease, by following component by weight mixed preparing form: Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part.
Described various component optimum ratio amount is: 35 parts of Herba Houttuyniae, 25 parts of Herb Polygoni Chinensiss, 25 parts of Herba polygoni hydropiperis, 25 parts, Radix Glycyrrhizae, 25 parts of Radix Isatidis, 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Sal, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Plantaginiss, 30 parts of Flos Loniceraes.
Treat a preparation method for the pure Chinese medicine composition of Anguillar japonica red fin fish disease, carry out as follows:
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;
(3) take by weight Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Herba Houttuyniae: pungent, be slightly cold, return lung meridian, there is the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
Herb Polygoni Chinensis: sour, puckery, cool, return liver, large intestine channel, there is heat-clearing and toxic substances removing, the antipruritic function of dampness removing; Cure mainly hygropyretic dysentery, eczema etc.
Herba polygoni hydropiperis: pungent, warm, return lung, liver, large intestine channel, there is the function of removing toxic substances, damp eliminating, dissipating blood stasis, hemostasis; Cure mainly dysentery, rheumatic arthralgia, carbuncle furuncle, eczema, traumatic hemorrhage etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Herba Hedyotidis Diffusae: bitter, sweet, cold, GUIXIN, liver, spleen channel, have the functions such as heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema, cures mainly laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, the puckery pain of pyretic stranguria, jaundice due to damp-heat, venom, the swollen hot carbuncle of skin ulcer etc.
Sal: cold, become, return stomach, kidney, lung, liver, large intestine, small intestine meridian, there is heat-clearing and toxic substances removing, removing heat from blood, softening the hard mass, parasite killing, antipruritic function; Cure mainly trusted subordinate's distension syndrome, constipation and anuresis, hemorrhage, skin infection etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Herba Plantaginis: sweet, cold, return lung, kidney, liver, small intestine meridian, there is clearing away heat and promoting diuresis, eliminate the phlegm, the function of removing heat from blood, removing toxic substances; Cure mainly that pyretic stranguria, short urination are red, diarrhea due to damp-heat, phlegm-heat cough, carbuncle sore tumefacting virus etc.
Flos Lonicerae: sweet, cold, attach to the lung and stomach meridians, there is the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
All herbal medicines, according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of Anguillar japonica red fin fish disease, are brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment Anguillar japonica red fin fish disease is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of the red fin of Anguillar japonica and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Herba Houttuyniae, 150 parts of Herb Polygoni Chinensiss, 150 parts of Herba polygoni hydropiperis, 150 parts, Radix Glycyrrhizae, 150 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weight 150 parts of Herba Hedyotidis Diffusaes, 100 parts of Sal, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Herba Plantaginiss, 200 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of Anguillar japonica red fin fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Herba Houttuyniae, 300 parts of Herb Polygoni Chinensiss, 250 parts of Herba polygoni hydropiperis, 250 parts, Radix Glycyrrhizae, 250 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weight 250 parts of Herba Hedyotidis Diffusaes, 150 parts of Sal, 300 parts of Pericarpium Citri Reticulataes, 300 parts of Herba Plantaginiss, 300 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of Anguillar japonica red fin fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 450 parts of Herba Houttuyniae, 400 parts of Herb Polygoni Chinensiss, 350 parts of Herba polygoni hydropiperis, 350 parts, Radix Glycyrrhizae, 350 parts of Radix Isatidis, mix 5-10 minute to even;
(3) take by weight 350 parts of Herba Hedyotidis Diffusaes, 200 parts of Sal, 400 parts of Pericarpium Citri Reticulataes, 400 parts of Herba Plantaginiss, 400 parts of Flos Loniceraes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
Clinical experiment animal selects 300 ages in days, body weight at 0.08kg-0.1kg, and Laboratory Diagnosed is the ill fish of Anguillar japonica red fin fish disease.Ill fish isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 60 tails, 3 groups of feeding environments are identical, and experiment is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment with " eel Yukangsan " by specification; Present composition group can be for oral administration by product of the present invention (the prepared compositions of the embodiment of the present invention 1), in 2.5% ratio, admixes bait feeding, every day 2-3 time, is used in conjunction 3-5 days; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 5th day) when following table is experiment end.
Table is the applicable cases contrast of the present invention and other medicines treatment Anguillar japonica red fin fish disease:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 23.3 | 52.7 | 40.0 |
| II | Eel Yukangsan group | 10.0 | 76.7 | 13.3 |
| III | Present composition group | 6.7 | 86.6 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with eel Yukangsan group aspect cure rate.
Safety testing:
Choose healthy Anguillar japonica 30 tails of 80 ages in days, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 take orally 10 days, during medication, there is not any bad or Deviant Behavior performance in healthy fish, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment Anguillar japonica red fin fish disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for Anguillar japonica red fin fish disease, it is characterized in that by following component by weight mixed preparing form: Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part.
2. the pure Chinese medicine composition for the treatment of according to claim 1 Anguillar japonica red fin fish disease, it is characterized in that by following component by weight mixed preparing form: 35 parts of Herba Houttuyniae, 25 parts of Herb Polygoni Chinensiss, 25 parts of Herba polygoni hydropiperis, 25 parts, Radix Glycyrrhizae, 25 parts of Radix Isatidis, 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Sal, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Herba Plantaginiss, 30 parts of Flos Loniceraes.
3. a preparation method for the pure Chinese medicine composition for the treatment of according to claim 1 Anguillar japonica red fin fish disease, is characterized in that carrying out as follows:
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Houttuyniae 25-45 part, Herb Polygoni Chinensis 15-40 part, Herba polygoni hydropiperis 15-35 part, Radix Glycyrrhizae 15-35 part, Radix Isatidis 15-35 part, mix 5-10 minute to even;
(3) take by weight Herba Hedyotidis Diffusae 15-35 part, Sal 10-20 part, Pericarpium Citri Reticulatae 20-40 part, Herba Plantaginis 20-40 part, Flos Lonicerae 20-40 part, mix 5-10 minutes to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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