CN107468796A - A kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition and preparation method - Google Patents
A kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition and preparation method, belong to veterinary Chinese medicine field.The Chinese medicine composition is made up of the bulk drug of following mass fraction：20~40 parts of the coptis, 50~70 parts of radix scutellariae, 35~55 parts of radix bupleuri, 40~60 parts of hairyvein agrimony, 10~30 parts of oyster, 50~70 parts of giant knotweed, 20~40 parts of garden burnet, 20~40 parts of saline cistanche, 30~50 parts of schizonepeta, 10~30 parts of radish seed, 15~35 parts of cloves, 25~45 parts of the root of herbaceous peony, 50~70 parts of golden cypress, 20~40 parts of the Radix Astragali.The present invention uses pure natural Chinese herbal medicine, securely and reliably, has no toxic side effect, and all medicines press monarch principle compatibility, safe and free of toxic and side effects, has the effect of clearing heat and detoxicating, antiviral, anti-inflammation, raising immunity of organisms.
Description
Technical field
The invention belongs to field of veterinary medicine preparation, and in particular to a kind of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition, simultaneously
Further relate to the preparation method of the Chinese medicine composition.
Background technology
Livestock and poultry virus transmission of infection is fast, often mass-sends, and it is anxious to fall ill, and often with fervescence, the death rate is high, due to virus
Variation is exceedingly fast, so often undesirable using vaccine immunity preventive effect.Such as：Porcine circovirus desease, blue otopathy, swine fever, pig stream
A variety of virus infection such as sense and porcine pseudorabies are responsible for the critical symptom of pig hyperpyrexia, and above-mentioned epidemic disease flows in the whole world
OK, it is difficult to prevent, great economic loss is brought to aquaculture.Clinically often prevented and treated at present by the way of drug combination various
High fever critical illness caused by animal viral infection, not only workload is big, stress be big, and cost is high, and effect is undesirable, so must
A kind of efficient antipyretic and antiviral medicine treated both principal and secondary aspect of disease must be developed.
China's natural resources of Chinese medicinal materials enriches, and modern medicine study result shows, many Chinese medicines contain abundant polysaccharide, alkaloid
The materials such as class, organic acid, glucoside, volatile oil, Chinese medicine preparation is used for animal made of these materials, can exempt from activation
Epidemic disease cell, strengthen immunologic function, the effect of antiviral, antibacterium, resisting stress.But Chinese herbal medicine also there are many defects, profit is such as absorbed
Expenditure is poor, works slow etc..In recent years, the extractive technique of Chinese herbal medicine earns widespread respect, and conventional is water extraction and alcohol precipitation method, but this method
Extraction efficiency is low, and extraction time length, high temperature is highly vulnerable to breakage active material etc..
Ultrasonic assistant extraction is extractive technique emerging in recent years.Target compound is extracted from dried material substantially to divide
For two steps:1) expansion of the infiltration of material, i.e. material and aquation；2) Soluble target compound is by spreading, permeating
Mass transport process from material to solvent.Research shows that ultrasonic wave can make plant cell wall produce hole, be advantageous to mesh in cell
The dissolution of compound is marked, mass transport process can be promoted.In addition, ultrasonic wave can also reduce raw meal particle size, so as to increase material with
The contact area of solvent, be advantageous to the extraction of target compound.Ultrasonic assistant extraction have it is easy to operate, cost is cheap, carries
Take the time is short, be easy to amplification production the advantages that.
The content of the invention
It is an object of the invention to provide a kind of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition.
Meanwhile the present invention also provides a kind of preparation method of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition, is made up of the bulk drug of following mass fraction：The coptis 20~40
Part, 50~70 parts of radix scutellariae, 35~55 parts of radix bupleuri, 40~60 parts of hairyvein agrimony, 10~30 parts of oyster, giant knotweed 50~70
Part, 20~40 parts of garden burnet, 20~40 parts of saline cistanche, 30~50 parts of schizonepeta, 10~30 parts of radish seed, cloves 15~
35 parts, 25~45 parts of the root of herbaceous peony, 50~70 parts of golden cypress, 20~40 parts of the Radix Astragali.
The bulk drug composition of the above-mentioned preferably following mass fraction of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition：The coptis
30 parts, 60 parts of radix scutellariae, 40 parts of radix bupleuri, 50 parts of hairyvein agrimony, 20 parts of oyster, 60 parts of giant knotweed, 30 parts of garden burnet, 30 parts of saline cistanche, schizonepeta
40 parts, 20 parts of radish seed, 25 parts of cloves, 35 parts of the root of herbaceous peony, 60 parts of golden cypress, 30 parts of the Radix Astragali.
A kind of preparation method of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition, is comprised the following steps that：
（1）Each bulk drug is accurately weighed according to mass fraction, is mixed after crushing, mistake 40-60 mesh sieves standby；
（2）In step（1）Mixture according to mass ratio be 1:（2~10）30~95% ethanol solution is added, after mixing
Soaking at room temperature 12~24 hours；
（3）Medicinal material after immersion is placed in be ultrasonically treated in environment and extracted, ultrasonic power 600w-1800w/kg medicinal materials, ultrasound
Frequency 800-1200kHz, ultrasonic time 30-50min, ultrasonic interval time 1-3min, ultrasonication number 1-3 times, medicinal material
25-45 DEG C of temperature；The separation slagging-off of 500 mesh sieves is crossed, residue adds 1-2 times of ethanol and washed 2-3 times, crosses the separation slagging-off of 500 mesh sieves,
Merging filtrate.
（4）By step（3）It is drying to obtain after medicinal material recovery ethanol after middle supersound process.
The step（2）In be stirred continuously during immersion treatment so that Chinese medicine complete swelling.
The step（3）In be stirred continuously after each be ultrasonically treated so that Chinese medicine is evenly distributed.
The step（4）It is middle that by medicinal material, low-temperature reduced-pressure is distilled to recover ethanol at 30~50 DEG C.
The present invention uses pure natural Chinese herbal medicine, securely and reliably, has no toxic side effect, following 14 taste Chinese medicines are according to monarch
Principle composition of prescription, giant knotweed, the coptis, radix scutellariae, golden cypress are monarch drug in a prescription in side, and garden burnet, schizonepeta, radix bupleuri, the Radix Astragali are ministerial drug, cloves, meat
Desert cistanche, radish seed are adjutant, oyster, the root of herbaceous peony, hairyvein agrimony to make medicine, all medical instruments have it is clearing heat and detoxicating, it is antiviral, anti-inflammation, carry
The effect of high immunity of organisms.
Each bulk drug effect is summarized as follows：
The coptis：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation is vomitted, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity,
Dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache, quench one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.Prepared RHIZOMA COPTIDIS with vino is apt on clear
It is burnt burning hot.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.Mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.Cornel coptis
Easypro liver anti-vomiting.For liver-stomach disharmony, acid regurgitation is vomitted；
Radix scutellariae：For the root of lamiaceae labiatae scutellaria plant radix scutellariae；Containing flavone compound for example baicalein, neobaicalein, scutelloside,
Wogonoside etc., also containing plurality of active ingredients such as β-sitosterol, campesterol and stigmasterol；It is bitter in taste, cold, return lung, the heart,
Liver, courage, large intestine channel；Energy clearing heat-fire, eliminating dampness removing toxic substances, stop blooding, be antiabortive；Cure mainly lung heat cough and asthma, high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility head
Bitterly, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis, fetal movement with fever, carbuncle swells furunculosis etc.；Modern pharmacology proves radix scutellariae tool
There are antimicrobial, platelet aggregation-against and anti-freezing, anti-oxidant, anticancer, reduce blood pressure and diuresis, reducing blood lipid and other effects；
Radix bupleuri：Hardship is flat, channel tropism, enter liver, gallbladder channel.Function：Deliver, bring down a fever, be soothing the liver, Xie Yu, rising Yang.Cure mainly：Cat fever, fever and chills
Contact, malaria, side of body distending pain, irregular menstruation.Modern pharmacological research proves：Radix bupleuri has：1st, it is antipyretic, antipyretic effect is steadily reliable；
2nd, calm, analgesia, has and releases distending pain uncomfortable in chest, open strongly fragrant regulating menoxenia；3rd, antibacterial, there is inhibitory action to tubercle bacillus；4th, anti-liver damage
Wound acts on；5th, antiviral, infected by influenza has strong inhibitory action, to cell caused by the 1st type poliomyelitis virus
Lesion is inhibited；
Hairyvein agrimony：Property it is bitter, puckery, put down, the thoughts of returning home, Liver Channel.Herb is robustness astringent hemostatic, has cardiac stimulant, rises blood pressure, blood coagulation, stops
Blood, cool blood, antibacterial etc. act on, and are widely used in the card of various bleedings.The desinsection in addition, product can still detoxify, can be with the boil carbuncle such as controlling
Under swollen, pruritus vulvae band.With 3 spoons of dry Agrimonies of hot-water soak（Hairyvein agrimony is also known as）10-15 minutes.Improve diarrhoea, mitigate skin
Stimulate, with the soak scrape skin of cooling.Slow down oral stimulation, have a sore throat：Gargled with the soak of warm.Experiment proves：
The hot water or ethanol extract of hairyvein agrimony are in vitro to hay bacillus, staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, good fortune
Shigella flexneri and typhoid bacillus etc. have inhibitory action, also have inhibitory action to Bacillus tuberculosis.Herb water extract and
Water-alcohol extract, to rabbit conjunctivitis caused by mustard oil or staphy lococcus infection, there is antiinflammation, the effect and celestial being
It is relevant containing the tannin that can generate condensed type tan acid anhydride (Phlobaphene) in crane grass；
Oyster：It is salty, it is slightly cold.Return liver, courage, kidney channel.It is calming the liver, transquilization with heavy material, softening and resolving hard mass, restrain astringent or styptic treatment for spontaneous sweating.Main dizziness and tinnitus,
Insomnia of palpitating with fear, scrofula goiter and tumor, abdominal mass lump in the abdomen, spontaneous sweating, uterine bleeding of passing out semen, with.Liver-invigorating detoxication, the liver glycogen of oyster exist with
In the liver and muscle of stored energy, the activation of division, regeneration, red blood cell with cell suffers from very deep relation, can be with
Liver function is improved, is set up, enhancing muscle power.Contained taurine can promote choleresis in oyster, exclude accumulation
Neutral fat in liver, improve the detoxication of liver；
Giant knotweed nature and flavor slight bitter, it is slightly cold.Giant knotweed has anti-inflammation, anti-oxidant, antiviral, antitumor, antitussive and antiasthmatic, liver protection, drops blood
Fat, decompression, cardiac stimulant, improve the effect such as microcirculation, antalgic and sedative, Hemorrhagic shock；
The main component of garden burnet：Containing tannin, sanguisorbin and retinoid material.Pharmacological action：1st, restrain, in intestines and stomach energy
Hemostasis, antidiarrheal, mitigation are oozed out；2nd, antibacterial, mainly to enteral pathogenic bacteria（Such as sonne bacillus, typhoid bacillus, paratyphoid bar
Bacterium etc.）There is inhibitory action, also have different degrees of inhibitory action to golden yellow staphylococcus, diplococcus meningitidis, large-scale tubercle bacillus；
Saline cistanche：Kidney-replenishing；Benefiting essence-blood；Ease constipation road.Main decline of kidney-YANG；The impotence of asthenia of essence and blood；Seminal emission；Gonorrhoea；The frequent micturition heeltap；
Pain in the back flaccidity of lower limbs；Tinnitus mesh is spent；Menstruation is spread out the phase；Fertility；Dry constipation of intestines；Desert cistanche contain abundant alkaloid, it is crystalline in
The compositions such as property material, amino acid, trace element, vitamin.Energy kidney-replenishing, benefiting essence-blood, can suppress the appearance of " deficiency of yang " symptom, prevent
Only weight loss.Also improving immunocompetence, formation and activity of the wheat-based diet to human lymphocyte have significant shadow
Ring, it can increase the breeder reaction of lymphocyte, so as to strengthen the immunologic function of body；
The effect of schizonepeta：Inducing diaphoresis dissipates wind, and promoting eruption, disappear sore, hemostasis.For catching a cold, measles without adequate eruption, have blood in stool, uterine bleeding, nosebleed epistaxis.
Deliver, wind-dispelling, regulating blood condition；Fries charcoal hemostasis.Cure cold heating, headache, abscess of throat, apoplexy lockjaw, spits blood, bleeding from five sense organs or subcutaneous tissue, has blood in stool；Collapse
Leakage, postpartum anemic fainting；Carbuncle swells, sore scabies, scrofula.Ching-chieh effectiveness is identical, and only the power of diverging is stronger；
Radish seed has decompression, antibacterial, antiinflammatory action；Also eliminating the phlegm, antibechic, relieving asthma improvement urinary function and reduction cholesterol, prevent
Only artery sclerosis etc. acts on；It can neutralize tetanus toxin and diphtheria toxin in vitro；
Cloves has promotion gastric secretion, strengthens eupepsy, mitigates nausea and vomiting, alleviation abdominal bloating, also analgesia, anti-inflammatory, resists
Convulsions, antibacterial, antithrombus formation, anti diar rhea, cholagogic and anti anoxia etc. act on；
The root of herbaceous peony：Nourishing blood and liver, relieved pain in delaying, hold back cloudy receipts sweat.Control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, deficiency of Yin hair
Heat, irregular menstruation, uterine bleeding, with；White peony root's total glycoside has humidification still to have reduction gland in addition the delayed allergy of mouse
Trypsase potency, antibacterial etc. act on；
Golden cypress：For the bark of Rutaceae cork tree platymiscium wampee or cork tree；Contain alkaloids such as jamaicin, phellodendrine, wood
Magnoflorine, jateorrhizine etc., also containing plurality of active ingredients such as limonin, obakunone, campesterol, stigmasterol；Bitter in taste,
It is cold, return kidney, bladder, large intestine channel；Can heat-clearing and damp-drying drug, purging intense heat and detonicating；Cure mainly damp-heat dysentery, diarrhea, jaundice, hectic fever due to yin labor heat, dispute
Raw sore, red eye, swell pain, skin sore etc.；Modern pharmacology proves that golden cypress has resisting pathogenic microbes, antipyretic and anti-inflammatory, anti-blood
Platelet aggregation and other effects, has facilitation to cardiovascular system, digestive system and central nervous system；
The Radix Astragali can strengthen body's immunity, liver protection, resisting stress, and have extensive antibacterial action, on the one hand can strengthen netted
The phagocytic function of endothelial system, make blood leukocytes and the significant increase of multinuclear leucocyte quantity, make macrophage phagocytic percentage and
The significant rising of phagocytic index, there are facilitation, the also energy with enhanced virus inducement interferon to humoral immunity, cellular immunity
Power, as easy catching a cold person flu epidemic season take the Radix Astragali, can not only significantly reduce times of common cold, and cold symptoms can be made
It is relatively light, shorten the course of disease, on the other hand can also strengthen body hypoxia-bearing and stress ability.
Beneficial effects of the present invention：Clearing heat and detoxicating in the present invention, antiviral veterinary Chinese medicinal composition has advantages below：
1st, inventive formulation is unique, has the effect of clearing heat and detoxicating, antiviral, raising immunity of organisms；
2nd, the present invention is extracted using low temperature ultrasonic extractive technique to each composition medicine in invention formulation, whole extraction process
Middle 25-45 DEG C of Extracting temperature, greatly remains the active component of medicine, and extraction is more abundant, more thorough；
3rd, made preparation is pure Chinese medicine product, nontoxic, to livestock and poultry internal organs not damaged, drug residue free, is had no drug resistance, cost
It is relatively low, and reach the effect effected a permanent cure；
4th, clinical practice shows to achieve good effect in terms of prophylactic treatment livestock and poultry.
Chinese medicine in the present invention is mainly plant origin, and its effective ingredient is concentrated mainly on into the cell, due to plant cell
Wall is thicker, and most of nonruminant alimentary canals are short, lacks peptide glycan catabolic enzyme again, it is impossible to be completely severed its cell membrane, its is effective
Composition can not discharge, so as to have influence on the bioavailability of effective components of Chinese medicinal.Therefore, using the Chinese medicine through simply crushing
Addition prevents and treats livestock and poultry in feed, its Clinical practice DeGrain.The present invention utilizes ultrasonic technique processing Chinese traditional medicine composition
Thing, using ethanol water as solvent, Chinese medicine, which fully soaks, is swelled cell, high frequency, high-power ultrasonic good directionality, penetrates energy
Power is extremely strong.Violent cavitation effect will occur in liquid in ultrasonication solidliquid mixture, form strong pressure pulses, disperse
Plant tissue is destroyed, accelerates solvent quick penetration compact tissue, improves plant component extraction rate.Ultrasonic wave can accelerating medium simultaneously
Molecular motion so that Extraction medium and plant component Rapid contact, mutually fused, mixing, also realize and improve some constituents extractions
The effect of efficiency.Under other ul-trasonic irradiation void effect have a strong impact on plant cell wall, microbial cell film, organelle etc. by
To mechanical damage；The generation of the cavitation bubble of ultrasonic wave, grow up, the high pressure of implosion broken caused moment, change cell permeability
And the structure of cell, cause ICP to raise rapidly, cause cell membrane explosion, its intracellular effective ingredient releasably comes out.
This method does not change the structure of effective ingredient in prescriptions of traditional Chinese medicine, but makes its cell wall rupture, from intracellular release
Out play a role, the cell membrane of rupture again can be as the carrier matrix of effective ingredient, while also serves as prebiotics in animal
Intestinal beneficial bacterium can be promoted to breed in vivo.This method has that penetration power is strong, and recovery rate is high, and extraction is quick, Extracting temperature is low, right
Active ingredient has the advantages that protective effect, while energy-conservation energy consumption significantly, pollution is few in medicinal material.
Present inventor is guidance according to Traditional Chinese medical theory, under substantial amounts of clinical test, from numerous Chinese medicines
Select suitable medicinal material and its proportioning one by one and formulate the extracting method of its patent medicine, reached 95% clinical effective rate and
100% preventive effect, there is wide market promotion prospect.
Embodiment
Following embodiments are only described in further detail to the present invention, but do not form any limitation of the invention.
Embodiment 1
Clearing heat and detoxicating in the present embodiment, antiviral veterinary Chinese medicinal composition, is made up of the bulk drug of following mass fraction：The coptis 20
Part, 50 parts of radix scutellariae, 35 parts of radix bupleuri, 40 parts of hairyvein agrimony, 10 parts of oyster, 50 parts of giant knotweed, 20 parts of garden burnet, 20 parts of saline cistanche, schizonepeta 30
Part, 10 parts of radish seed, 15 parts of cloves, 25 parts of the root of herbaceous peony, 50 parts of golden cypress, 20 parts of the Radix Astragali.
A kind of preparation method of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition, is comprised the following steps that：
（1）Each bulk drug is accurately weighed according to mass fraction, is mixed after crushing, 40 mesh sieves excessively standby；
（2）In step（1）Mixture according to mass ratio be 1:10 add 30% ethanol solution, soaking at room temperature 12 after mixing
Hour, it is stirred continuously during immersion treatment, so that Chinese medicine complete swelling；
（3）Medicinal material after immersion is placed in be ultrasonically treated in environment and extracted, ultrasonic power 1800w/kg medicinal materials, supersonic frequency
1200kHz, ultrasonic time 50min, ultrasonic interval time 3min, ultrasonication number 3 times, 25 DEG C of medicinal material temperature；Cross 500 mesh
Sieve separation removes the gred, and residue adds 1-2 times of ethanol and washed 2-3 times, crosses the separation slagging-off of 500 mesh sieves, merging filtrate, in each ultrasound
It is stirred continuously after processing, so that Chinese medicine is evenly distributed.
（4）By step（3）Medicinal material after middle supersound process is drying to obtain at 30 DEG C after low-temperature reduced-pressure recovery ethanol.
Embodiment 2
Clearing heat and detoxicating in the present embodiment, antiviral veterinary Chinese medicinal composition, is made up of the bulk drug of following mass fraction：The coptis 30
Part, 60 parts of radix scutellariae, 40 parts of radix bupleuri, 50 parts of hairyvein agrimony, 20 parts of oyster, 60 parts of giant knotweed, 30 parts of garden burnet, 30 parts of saline cistanche, schizonepeta 40
Part, 20 parts of radish seed, 25 parts of cloves, 35 parts of the root of herbaceous peony, 60 parts of golden cypress, 30 parts of the Radix Astragali.
A kind of preparation method of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition, is comprised the following steps that：
（1）Each bulk drug is accurately weighed according to mass fraction, is mixed after crushing, 50 mesh sieves excessively standby；（2）In step（1）It is mixed
In compound according to mass ratio be 1:6 add 60% ethanol solution, soaking at room temperature 18 hours after mixing, during immersion treatment
It is stirred continuously, so that Chinese medicine complete swelling；（3）Medicinal material after immersion is placed in be ultrasonically treated in environment and extracted, ultrasonic wave work(
Rate 1200w/kg medicinal materials, supersonic frequency 1000kHz, ultrasonic time 40min, ultrasonic interval time 2min, ultrasonication number 2
It is secondary, 35 DEG C of medicinal material temperature；The separation slagging-off of 500 mesh sieves is crossed, residue adds 1-2 times of ethanol and washed 2-3 times, crosses the separation of 500 mesh sieves and removes
Slag, merging filtrate, it is stirred continuously after each be ultrasonically treated, so that Chinese medicine is evenly distributed.（4）By step（3）At middle ultrasound
Medicinal material after reason is drying to obtain at 40 DEG C after low-temperature reduced-pressure recovery ethanol.
Embodiment 3
Clearing heat and detoxicating in the present embodiment, antiviral veterinary Chinese medicinal composition, is made up of the bulk drug of following mass fraction：The coptis 40
Part, 70 parts of radix scutellariae, 55 parts of radix bupleuri, 60 parts of hairyvein agrimony, 30 parts of oyster, 70 parts of giant knotweed, 40 parts of garden burnet, 40 parts of saline cistanche, schizonepeta 50
Part, 30 parts of radish seed, 35 parts of cloves, 45 parts of the root of herbaceous peony, 70 parts of golden cypress, 40 parts of the Radix Astragali.
A kind of preparation method of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition, is comprised the following steps that：
（1）Each bulk drug is accurately weighed according to mass fraction, is mixed after crushing, 60 mesh sieves excessively standby；（2）In step（1）It is mixed
In compound according to mass ratio be 1:2 add 95% ethanol solution, soaking at room temperature 24 hours after mixing, during immersion treatment
It is stirred continuously, so that Chinese medicine complete swelling；（3）Medicinal material after immersion is placed in be ultrasonically treated in environment and extracted, ultrasonic wave work(
Rate 600w/kg medicinal materials, supersonic frequency 800kHz, ultrasonic time 30min, ultrasonic interval time 1min, ultrasonication number 1
It is secondary, medicinal material temperature 45 C；The separation slagging-off of 500 mesh sieves is crossed, residue adds 1-2 times of ethanol and washed 2-3 times, crosses the separation of 500 mesh sieves and removes
Slag, merging filtrate, it is stirred continuously after each be ultrasonically treated, so that Chinese medicine is evenly distributed.（4）By step（3）At middle ultrasound
Medicinal material after reason is drying to obtain at 50 DEG C after low-temperature reduced-pressure recovery ethanol.
Embodiment 4：Clinical observation
（1）General information the present inventor carries out clinical observation treatment in March, 2016-May to the pig of 160 aftosas.It is led
The clinical manifestation is wanted to be：Blister rash occurs for mucous membrane of mouth, hoof and skin of breast.What sb.'s illness took a turn for the worse, asthenia universalis, muscle hair
Tremble, appetite is useless exhausted, and walking is waved, astasia.
（2）Treatment method：The medicine of the embodiment of the present invention 2 is admixed into feed by the 0.1% of feed gross mass and even feeds 7-10
Day.（3）Efficacy assessment standard " healing "：The Clinical symptom and signs such as the blister rash of mucous membrane of mouth, hoof and skin of breast disappear,
The symptoms such as asthenia universalis, muscle are shaken, appetite is useless absolutely, walking is waved, astasia disappear, and body temperature is normal, limb function activity
Recover normal." effective "：Clinical symptoms are clearly better or most of disappearance.Engineering noise：Clinical symptom and sign is without improvement.
（4）Therapeutic effect：Clinical cure 157, accounts for 98.1%；Effective 3, account for 1.9%；Invalid 0；Total effective rate
100%。
Following Clinical Treatment Test similarly confirms the good result of the present invention：
Test example 5 treats pig circular ring virus II types disease
1st, clinical trial animal is from the ill pig that Laboratory Diagnosed is pig circular ring virus II types disease.The isolation of ill pig is independent
Raising, complete feed is fed, and be randomly divided into 3 groups, every group 66,3 groups of feeding environments are identical, and experiment is carried out 10 days altogether；
Blank control group is without any processing, and treatment is used according to an instruction with commercially available qingwen baidu powder for animals in drug control group；This hair
Bright Chinese medicine composition group can be by product of the present invention (composition obtained by the embodiment of the present invention 3) feeding illness pig etc., and day takes
Measure and be：It is daily 2-3 times by the present invention per the 1 ton of feeding of 250g spices or the 500kg that drinks water, 5-7 days are used in conjunction；Pass through stomach and intestine after oral
Road absorbs the purpose for reaching treatment disease.
Curative effect determinate standard is invalid：In administration and observation period, it is invalid that no effect or DeGrain are considered as；Effectively：Give
Medicine and various clinical symptom remissions in the observation period, diarrhoea number significantly reduce, disease and appetite, the essence such as expiratory dyspnea, anaemia jaundice
Refreshing state takes a turn for the better, or the pig cured completely is accordingly to be regarded as effectively；Cure：Various clinical symptom disappearances, diarrhoea stop, and breathing recovers just
Result of the test is shown in Table 1.Variance analysis is carried out using SPSS12.0 softwares to experimental data, result of the test data are carried out
Significance test.
The pig circular ring virus II type disease treatment results of table 1
| Group | Experiment pig number（Head） | Cure pig number（Head） | Cure rate（%） | Total effectively pig number（Head） | Total effective rate（%） |
| Present composition group | 22 | 20 | 90.9 | 21 | 95.5 |
| Drug control group | 22 | 12 | 54.5 | 15 | 68.2 |
| Blank group | 22 | 0 | 0 | 2 | 9.1 |
Experimental result is found：The total effective rate of present composition group is 95.5%, cure rate 90.9%；Drug control group
Total effective rate is 68.2%, and cure rate is only 54.5%.The total effective rate of blank group is only 9.1%.Present composition group with
Drug control group is compared, and difference extremely significantly (P ＜ 0.01), medicaments compound plurality of Chinese of the present invention, is treated both principal and secondary aspect of disease, effect is more
It is good.The results show, a kind of clearing heat and detoxicating, antiviral veterinary Chinese medicinal composition of the present invention are reasonable to pig circular ring virus II types
The therapeutic effect thought.
Claims (6)
1. a kind of clearing heat and detoxicating antiviral veterinary Chinese medicinal composition, it is characterised in that be made up of the bulk drug of following mass fraction：
20~40 parts of the coptis, 50~70 parts of radix scutellariae, 35~55 parts of radix bupleuri, 40~60 parts of hairyvein agrimony, oyster 10~30
Part, 50~70 parts of giant knotweed, 20~40 parts of garden burnet, 20~40 parts of saline cistanche, 30~50 parts of schizonepeta, radish seed 10~
30 parts, 15~35 parts of cloves, 25~45 parts of the root of herbaceous peony, 50~70 parts of golden cypress, 20~40 parts of the Radix Astragali.
2. clearing heat and detoxicating, the antiviral veterinary Chinese medicinal composition according to claim 1, it is characterised in that by following matter
Measure the bulk drug composition of number：30 parts of the coptis, 60 parts of radix scutellariae, 40 parts of radix bupleuri, 50 parts of hairyvein agrimony, 20 parts of oyster, 60 parts of giant knotweed,
30 parts of garden burnet, 30 parts of saline cistanche, 40 parts of schizonepeta, 20 parts of radish seed, 25 parts of cloves, 35 parts of the root of herbaceous peony, 60 parts of golden cypress, 30 parts of the Radix Astragali.
A kind of 3. method that Chinese medicine is prepared using veterinary Chinese medicinal composition as claimed in claim 1 or 2, it is characterised in that specific
Step is as follows：
（1）Each bulk drug is accurately weighed according to parts by weight, is mixed after crushing, mistake 40-60 mesh sieves standby；
（2）In step（1）Mixture according to weight ratio be 1:（2~10）30~95% ethanol solution is added, after mixing
Soaking at room temperature 12~24 hours；
（3）Medicinal material after immersion is placed in be ultrasonically treated in environment and extracted, ultrasonic power 600w~1800w/kg medicinal materials, ultrasound
800~1200kHz of frequency, 30~50min of ultrasonic time, ultrasonic 1~3min of interval time, ultrasonication number 1~3 time,
25~45 DEG C of medicinal material temperature；The separation slagging-off of 500 mesh sieves is crossed, residue adds 1~2 times of ethanol and washed 2~3 times, crosses 500 mesh sieves point
From slagging-off, merging filtrate；
（4）By step（3）It is drying to obtain after medicinal material recovery ethanol after middle supersound process.
4. the method according to claim 3, it is characterised in that：The step（2）During immersion treatment constantly
Stirring.
5. the method according to claim 3, it is characterised in that：The step（3）In after each be ultrasonically treated constantly
Stirring.
6. the method according to claim 3, it is characterised in that：The step（4）It is middle by medicinal material at 30~50 DEG C
Lower low-temperature reduced-pressure is distilled to recover ethanol.
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| CN116688012A (en) * | 2023-07-05 | 2023-09-05 | 浙江工业大学 | Buccal tablet for preventing influenza |
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