CN103055207B - Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof - Google Patents
Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp. The composition is prepared by mixing the following components in part by weight: 15 to 35 parts of rhubarb, 15 to 35 parts of baikal skullcap root, 15 to 35 parts of isatis root, 15 to 35 parts of propolis, 15 to 35 parts of honeysuckle flower, 15 to 35 parts of amur corktree bark, 20 to 40 parts of quassia, 20 to 40 parts of malt, 20 to 40 parts of medicated leaven, and 20 to 40 parts of Chinese mugwort leaf. The pure Chinese medicinal composition is reasonable in formula, easy to prepare, and high in bioavailability, is the pure Chinese medicinal composition, does not have any toxic or side effects, can treat both symptoms and root causes, has a very obvious curative effect and is obtained through super fine crushing; the medicine residues and medicine resistance are avoided; and the clinical results prove that the pure Chinese medicinal composition has a special effect of treating infectious hemorrhagic disease of the grass carp.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof.
Background technology
Ctenopharyngodon idellus infectiousness hemorrhagic disease is a kind of infectious disease of serious harm Ctenopharyngodon idellus, and this is a kind of popular wide, season is long, sickness rate is high, mortality rate is high a kind of disease.Production to Grass Carp Juveniles causes heavy losses.This disease pathogen is GCHV, generally still has popularly in late June to early October, and be epidemic peak season August.This disease shows as the mottled or block hyperemia of each Organ and tissue of Ctenopharyngodon idellus inside and outside, and congested phenomenon appears in the organs such as oral cavity, the gill cover, fin base, muscle, intestinal, liver,spleen,kidney, is " red muscularity ".10～15 centimetres of above Ctenopharyngodon idellus kinds, take intestinal, fin base, the gill cover and oral cavity hyperemia as main, are " the thin gill cover type of red fin " or " intestinal type ", and in various degree hemorrhage appears in Ctenopharyngodon idellus more than an age.
Sharply, General Symptoms worsens fast the disease of primary disease, and malpractice easily causes death, causes serious economic loss to fish culture industry, and mortality rate is generally between 50%-80%.
This disease almost spreads all over all fish cultures country of the world, is widely distributed.Primary disease western medical treatment mainly uses antiviral agents and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.And therapeutic principle of traditional Chinese medicine is take heat-clearing and toxic substances removing, removing heat from blood, harmonizing yingfen and weifen as the rule for the treatment of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, particle diameter is excessive, and drug release is slower, causes its bioavailability lower, and clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, micronizing, bioavailability are high, and the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, micronizing, bioavailability are high, treating both the principal and secondary aspects of a disease, pure Chinese medicine composition of effective treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part.
Described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 25 parts of Radix Isatidis, 25 parts of propolis, 25 parts of Flos Loniceraes, 25 parts of Cortex Phellodendris, 30 parts of Ramulus Et Folium Picrasmaes, 30 parts, Fructus Hordei Germinatus, 30 parts of Massa Medicata Fermentata, 30 parts of Folium Artemisiae Argyis.
Treat a preparation method for the pure Chinese medicine composition of Ctenopharyngodon idellus infectiousness hemorrhagic disease, carry out as follows:
(1) the each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, mix 5-10 minute to even;
(3) take by weight Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Flos Lonicerae: sweet, cold, attach to the lung and stomach meridians, there is the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Ramulus Et Folium Picrasmae: bitter, cold, return lung, large intestine channel, there is the function of heat-clearing and toxic substances removing, removing dampness and killing parasites; Cure mainly respiratory tract infection, pneumonia, acute gastroenteritis, dysentery, biliary tract infection, eczema etc.
Fructus Hordei Germinatus: sweet, flat, return spleen, stomach warp, there is the function of spleen benefiting and stimulating the appetite, promote qi circulation digestion promoting; Cure mainly that food stagnation does not disappear, tripe is swollen etc.
Massa Medicata Fermentata: sweet, pungent, warm, return stomach, spleen channel, the function that there is invigorating the spleen and regulating the stomach, helps digestion in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Folium Artemisiae Argyi: acrid, bitter, warm, return liver,kidney,spleen warp, there is the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
All herbal medicines, according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of Ctenopharyngodon idellus infectiousness hemorrhagic disease, are brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's theory, optimizes this ten herbal medicine, and they is formed according to optimum ratio, and clinical practice proves that treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Radix Et Rhizoma Rhei, 150 parts of Radix Scutellariaes, 150 parts of Radix Isatidis, 150 parts of propolis, 150 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weight 150 parts of Cortex Phellodendris, 200 parts of Ramulus Et Folium Picrasmaes, 200 parts, Fructus Hordei Germinatus, 200 parts of Massa Medicata Fermentata, 200 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Scutellariaes, 250 parts of Radix Isatidis, 250 parts of propolis, 250 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weight 250 parts of Cortex Phellodendris, 300 parts of Ramulus Et Folium Picrasmaes, 300 parts, Fructus Hordei Germinatus, 300 parts of Massa Medicata Fermentata, 300 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) the each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Radix Et Rhizoma Rhei, 350 parts of Radix Scutellariaes, 350 parts of Radix Isatidis, 350 parts of propolis, 350 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weight 350 parts of Cortex Phellodendris, 400 parts of Ramulus Et Folium Picrasmaes, 400 parts, Fructus Hordei Germinatus, 400 parts of Massa Medicata Fermentata, 400 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
Clinical experiment animal selects 150 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus infectiousness hemorrhagic disease.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 30 tails, 3 groups of feeding environments are identical, and experiment is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment with " fish is precious loose " by specification; Present composition group can be for oral administration by product of the present invention (the prepared compositions of the embodiment of the present invention 1), admixes bait feeding in 2.5% ratio, every day 2-3 time, is used in conjunction 3-5 days; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 53.3 | 30.0 | 16.7 |
| II | The precious loose group of fish | 13.3 | 73.4 | 13.3 |
| III | Present composition group | 3.3 | 86.7 | 10.0 |
This clinical effectiveness statistical analysis, the precious loose group of present composition treatment group and fish extremely significantly (P < 0.01) of difference compared with aspect cure rate.
Safety testing:
Choose 80 age in days healthy grass carp 30 tails, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 take orally 10 days, during medication, there is not any bad or Deviant Behavior performance in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that pure Chinese medicine composition to this treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for Ctenopharyngodon idellus infectiousness hemorrhagic disease, it is characterized in that by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part.
2. the pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 25 parts of Radix Isatidis, 25 parts of propolis, 25 parts of Flos Loniceraes, 25 parts of Cortex Phellodendris, 30 parts of Ramulus Et Folium Picrasmaes, 30 parts, Fructus Hordei Germinatus, 30 parts of Massa Medicata Fermentata, 30 parts of Folium Artemisiae Argyis.
3. a preparation method for the pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1, is characterized in that carrying out as follows:
(1) the each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, mix 5-10 minute to even;
(3) take by weight Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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