CN113499425A

CN113499425A - Composition for treating viral influenza and preparation method thereof

Info

Publication number: CN113499425A
Application number: CN202111028471.XA
Authority: CN
Inventors: 杨继广
Original assignee: Beijing Gongyuan Bencao Biotechnology Co ltd
Current assignee: Beijing Gongyuan Bencao Biotechnology Co ltd
Priority date: 2021-09-02
Filing date: 2021-09-02
Publication date: 2021-10-15

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and discloses a composition for treating viral influenza and a preparation method thereof. Regulating middle energizer with pericarpium Citri Tangerinae for eliminating phlegm; semen Scaphii Lychnophori has effects in clearing lung-heat and eliminating phlegm; perilla frutescens has the effects of relieving exterior syndrome and dispelling cold; rhodiola rosea strengthens spleen and tonifies qi; prepared licorice root, radix Glycyrrhizae Praeparata has the effects of moistening lung, removing toxic substance, and harmonizing the effects of the other drugs; fructus momordicae clears away the lung-heat and relieves sore throat, and eliminates phlegm and stops coughing; the cordate houttuynia has the functions of clearing away heat and toxic materials; the almond can relieve cough and asthma; exocarpium Citri rubrum is used for eliminating dampness and phlegm; ramulus Cinnamomi warms and unblocks meridians; the ginger relieves exterior syndrome, dispels cold, warms lung and relieves cough; lily bulb nourishing yin and moistening lung; tuckahoe induces diuresis to alleviate edema; the seville orange flower can regulate qi and relieve chest stuffiness; honeysuckle flower can clear blood toxin; radix Puerariae has effects of relieving muscles and reducing fever; the ageratum is fragrant and turbid; bluish dogbane has the functions of clearing heat and promoting urination; herba Menthae is effective in dispelling wind and heat; the Chinese yam has the effects of tonifying qi and nourishing yin; the Chinese olive has the effects of clearing heat and removing toxicity, and after all the raw materials are reasonably mixed, the effects of clearing fire and diminishing inflammation, warming middle energizer and dispelling cold, clearing damp and removing toxicity, inhibiting bacteria and diminishing inflammation and improving immunity are achieved. The preparation method is simple, ensures the precipitation rate of the effective components, and the prepared finished product is granules, which also aims to improve the absorption rate of patients on the effective components.

Description

Composition for treating viral influenza and preparation method thereof

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a composition for treating viral influenza and a preparation method thereof.

Background

Viral influenza is an upper respiratory infectious disease caused by viral infection, can be transmitted by air and contact, and is often manifested as fever, nasal obstruction, sneezing, rhinorrhea, dry throat, pharyngalgia, cough, headache, fatigue, weakness, inappetence and the like. Viral influenza can be divided into common cold, influenza and acute viral pharyngitis, and is a series of symptoms caused by respiratory tract injury caused by excessive virus propagation in respiratory tract, and is easy to cause death when serious.

At present, the common medicines for treating various colds are combined by Chinese patent medicines, western medicines or Chinese and western medicines, and the following modes are mainly adopted: (1) pure oral medication; (2) intramuscular injection; (3) the mode is a conventional treatment method, has a good effect on simple cold, but has a slight effect on complications caused by high fever of cold, particularly viral cold, and patients cannot be cured for a long time or even die.

However, no drug which can quickly and effectively relieve and cure viral influenza is developed at present, and the dosage can only be increased. It is known by people that the medicine is three-way toxic, and large dosage of the medicine can cause toxic and side effects of different degrees on the intestines, stomach, liver, kidney, bladder and other viscera of a patient, even can reduce the immunity resistance of the patient, is harmful to the health of people during treatment, can cause secondary damage sometimes, prolongs the treatment period, has high cost and causes serious economic burden to the patient.

Modern medicine considers that the virus infection of a plurality of viruses belongs to intracellular invasion, symptomatic treatment is generally adopted, including antipyretic and analgesic and prevention and treatment of secondary bacterial infection, and the effect of common antiviral medicines is not ideal.

Disclosure of Invention

In order to solve the above problems in the prior art, the present invention aims to provide a composition for treating viral influenza and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the composition for treating the viral influenza is mainly prepared from the following raw materials in parts by mass:

3-10 parts of dried orange peel, 5-15 parts of boat-fruited sterculia seed, 5-10 parts of purple perilla, 6-12 parts of rhodiola rosea, 6-12 parts of honey-fried licorice root, 10-30 parts of momordica grosvenori, 15-25 parts of houttuynia cordata, 3-10 parts of almond, 3-10 parts of exocarpium citri rubrum, 3-9 parts of cassia twig, 3-9 parts of ginger, 6-12 parts of lily, 10-15 parts of poria cocos, 3-5 parts of seville orange flower, 6-15 parts of honeysuckle, 9-15 parts of radix puerariae, 5-10 parts of ageratum, 5-10 parts of apocynum venetum, 3-6 parts of mint, 15-30 parts of Chinese yam and 4.5-9 parts of Chinese olive.

Pericarpium Citri Tangerinae, mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. Compendium (compendium): orange peel, bitter in flavor and purging in property can dry, pungent in flavor and dispersing in property and warm in property. For all kinds of diseases, it is always used to regulate qi and dry dampness, tonics are used to tonify qi, purgatives are used to purge qi, ascending qi and descending qi. The spleen is the mother of original qi and the lung is the key of qi absorption, so orange peel is the key of qi of the two meridians, but it can tonify and purge ascending and descending along with it. "nature and taste: warm in nature, pungent and bitter in flavor. Meridian tropism: enter spleen, stomach and lung meridians. The main treatment effects are as follows: regulate qi-flowing for strengthening spleen, regulate middle energizer, dry dampness and resolve phlegm. It can be used for treating abdominal distention, pain, and dyspepsia due to qi stagnation of spleen and stomach. Chest oppression, abdominal distension, poor appetite and loose stool due to damp-turbidity obstruction. Cough and dyspnea due to phlegm-dampness obstructing the lung. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm. Chenpi is warm in nature and can nourish spleen, pungent in nature and bitter in nature can invigorate spleen. Because Chen Pi governs qi movement of spleen and stomach, spleen and stomach are in the middle energizer and qi of middle energizer passes through, qi of triple energizer also surges. The triple energizer is the organ of profanity and governs dampness to pass water.

Boat-fruited sterculia seed, traditional Chinese medicine name. Is mature seed of Sterculialychnophora hance of Sterculiaceae, Pinctada Margaritifera. Has the effects of clearing lung-heat, eliminating phlegm, relieving sore throat, relieving voice, and loosening bowel to relieve constipation. It can be used for treating hoarseness due to lung heat, throat pain, cough, constipation due to dryness-heat, headache, and conjunctival congestion. Sweet taste and cold nature; it enters lung and large intestine meridians. Chemical components: the seed contains fat-sea element in the outer layer and galactose and pentose (mainly arabinose) in the peel. The pharmacological action is as follows: the fat and large sea food has the function of contracting vascular smooth muscle; can improve mucosal inflammation. Relieving spasmodic pain. The water extract has the effects of promoting enterokinesia and relieving diarrhea, and has the strongest effect on the kernels. The semen Armeniacae amarum solution (made from defatted dry powder) has blood pressure lowering effect. Toxicological effects scaphium scaphigerum seed (fat-free dry powder) is used for acute poisoning tests, which can show that rabbits have dyspnea and dyskinesia; after the dogs die after a large amount of continuous use for 10-15 days, pulmonary congestion, edema and hepatic lipidosis can be seen; half lethal oral LD of mice₅₀It was 12.96 g/kg. Intravenous injection of a large amount (1% 2ml) of boat-fruited sterculia seed aqueous infusion into rabbits showed that respiration was stopped first, the heart was still beating, and the gastrointestinal surface was very red.

Purple perilla, name of traditional Chinese medicine. Is stem and leaf of Perilla Perillarietescens (L.) Britt. of Perilla of Labiatae. Its leaves are called perilla leaves, and its stems are called perilla stems. Has effects of relieving exterior syndrome, dispelling cold, promoting qi circulation, relieving epigastric distention, preventing miscarriage, and relieving fish and crab toxin. It can be used for treating wind-cold type common cold, qi stagnation of spleen and stomach, chest distress, emesis, fetal qi adverse rising, threatened abortion, seven emotions stagnation, phlegm stagnation, and syphilis, abdominal pain, emesis, and diarrhea due to poisoning of fish and crab. Pungent and spicy taste, slight heat in property; entering the cold channel. Contains volatile oil, which mainly contains perillaldehyde, levolimonene and a small amount of alpha-pinene. 1. Bacteriostasis: has different degrees of inhibition effects on staphylococcus, streptococcus, typhoid bacteria, large intestine bacteria, dysentery bacteria, diphtheria bacillus, meningococcus, catacoccus, influenza virus and candida albicans. Can inhibit growth of filamentous fungi on skin. 2. The antipyretic effect is as follows: it can dilate skin blood vessel, stimulate sweat gland secretion and relieve fever. 3. Effects on the central nervous system: the water extract and perillaldehyde can prolong sleep time of barbiturate in male mouse, and has effects of inhibiting upper larynx nerve reflex of cat, and inhibiting excitability membrane of snail nerve cell and frog sciatic nerve fiber. The aqueous extract can inhibit the exercise capacity of rats. Perillaldehyde has tranquilizing effect. 4. Impact on the respiratory system: can reduce bronchial secretion, relieve bronchospasm, and has significant effect of relieving cough caused by acrolein or citric acid, and mouse phenol red test shows positive effect, so it can be proved that Perillae herba has effects of eliminating phlegm, relieving cough and relieving asthma. 5. Effects on the digestive system: can promote secretion of digestive juice and increase gastrointestinal motility. 6. Effects on the reproductive system: can inhibit uterine contraction and prevent miscarriage. 7. Effects on metabolism: on the premise of feeding nitrogen foods with equal calorie and the like, the weight, the liver weight, the plasma cholesterol, the liver cholesterol, the blood sugar and the acid phosphate activity of the rabbits fed with perilla oil are increased to different degrees compared with those of the control group. 8. Hemostasis effect: the Perillae herba can shorten blood coagulation time, blood plasma recalcification time and thrombin activating time.

Rhodiola root, name of Chinese medicine. Is rhizome of rhodiola rosea Rholiola rosea limn. or rhodiola crenulata R.euryphylla (Frod.) S.H.Fu. of Crassulaceae. Has the effects of invigorating spleen, invigorating qi, clearing lung-heat, relieving cough, promoting blood circulation, and removing blood stasis. It is used for treating spleen qi deficiency syndrome, lung yin deficiency, and cough due to lung heat. Sweet taste and cold nature; it enters spleen and lung meridians. Chemical components: the product contains salidroside, benzhydryl piperidine, beta-sitosterol, etc. The pharmacological action is as follows: rhodiola rosea or salidroside has the effects of resisting fatigue, anoxia, cold and microwave radiation, improving work efficiency and mental activity, enhancing excitability of brainstem reticular system, enhancing response to light and electrical stimulation, and regulating the content of central nervous system medium to be normal. The rhodiola rosea can enhance the secretion function of thyroid, adrenal gland and ovary, improve the total protein content of muscle and the level of RNA, increase the number of hemoglobin and erythrocyte in blood, promote the normalization of oxidative metabolism index of loaded muscle, and resist tetanus toxin. Rhodiola rosea pair S₁₈₀The sarcoma cell has inhibitory effect.

Radix Glycyrrhizae Preparata is a plant of Leguminosae, and is baked with Mel. Radix Glycyrrhizae Preparata contains glycyrrhizin, glycyrrhetinic acid, and Glycyrrhiza polysaccharide, and has antiinflammatory, antiallergic, immunity regulating, antitumor, and analgesic effects. Therefore, the main effects of honey-fried licorice root are to harmonize the middle warmer, relieve urgency, moisten lung, remove toxicity, and harmonize the other drugs. It is commonly indicated for weakness of spleen and stomach, lassitude, palpitation and intermittent pulse, and can relieve subsidiary toxicity. The clinical application of radix Glycyrrhizae Preparata is mostly radix Glycyrrhizae Preparata decoction, which is prepared from radix Glycyrrhizae Preparata as main raw material. Therefore, the efficacy and action of gan-ji-gan-Cao can be analyzed from gan-ji-gan-Cao decoction. By integrating the physicians of all generations, the following four points are considered to be the main efficacies and effects of the prepared licorice decoction: the functions of nourishing yin, enriching blood, tonifying qi and blood, and regulating yin and yang.

Momordica grosvenori, the name of traditional Chinese medicine. Is dried fruit of Momordica grosvenori Swingle belonging to genus Momordica of family Cucurbitaceae. Has the effects of clearing lung-heat, relieving sore throat, eliminating phlegm, relieving cough, and loosening bowel to relieve constipation. It can be used for treating cough, asthma, pharyngalgia, and constipation. Sweet in taste and cool in nature; it enters lung and large intestine meridians. Chemical components: the fruit mainly contains triterpene glycosides including siamenoside I and mogroside II_EIII, V, VI, mogroside, flavone components kaempferol-3, 7-alpha-L dirhamnoside and mogroside D-mannitol, and also contains a large amount of glucose and fructose, manganese, iron, nickel and the likeMore than 20 inorganic elements, protein, vitamin C, E, etc. The kernel contains oil component, and the fatty acid includes linoleic acid, oleic acid, palmitic acid, etc. The pharmacological action is as follows: the aqueous extract has obvious effects of relieving cough and eliminating phlegm, has the effect of reducing the activity of serum glutamic-pyruvic transaminase, can obviously improve the percentage of peripheral ascorbyl naphthyl acetate esterase positive lymphocytes of experimental animals, and prompts that the cellular immune function of an organism can be enhanced, and the large dose of momordica grosvenori can improve the ratio of spleen-specific rosette forming cells and has no obvious effect on the granulocyte phagocytosis rate in peripheral blood. The water extract can inhibit cariogenic effect of mutans bacteria.

Cordate houttuynia, name of Chinese traditional medicine. Is dried aerial part of houttuynia cordata Thunb of houttuynia of Saururaceae. Has effects of clearing away heat and toxic materials, eliminating carbuncle, expelling pus, promoting urination, and treating stranguria. It can be used for treating lung abscess with purulent vomiting, cough due to lung heat, sore due to heat-toxin, carbuncle, stranguria due to damp-heat, and dysentery due to damp-heat. Pungent taste and slightly cold nature; it enters lung meridian. Chemical components: the product contains houttuynin, volatile oil, houttuynine, quercetin, potassium chloride, etc. The pharmacological action is as follows: the houttuynin has different degrees of inhibition effects on various gram positive and negative bacteria such as staphylococcus aureus, diplococcus pneumoniae, streptococcus A, bacillus influenzae, catacoccus, typhoid bacillus, tubercle bacillus and the like; it is non-volatile extracted with diethyl ether, and has antiviral effect. The product has effects in improving phagocytic ability of leukocyte, enhancing immunity, and relieving inflammation. The contained quercetin and potassium salt can dilate renal artery and increase renal artery blood flow, thus having stronger diuretic effect. In addition, it also has analgesic, hemostatic, tissue regeneration promoting, wound healing promoting, and antitussive effects.

Almond, the name of traditional Chinese medicine. Is Armeniaca vulgaris Lam [ Prunus Armeniaca L of Prunus of Rosaceae.]Prungaris lam. var. ansu (Maxim) Yu et Lu [ prunus armeniaca l. var. ansu Maxim.]And apricots a. sibirica (L.) Lam. [ prunus sibirica L.]Northeast apricot a. mandshurica (Maxim.) Skv. [ prunumandshurica (Maxim.) Koehne]The seed of (1). Has effects of relieving cough and asthma, and loosening bowel to relieve constipation. It can be used for treating cough, asthma, chest fullness, excessive phlegm, blood deficiency, dry body fluid, constipation due to intestinal dryness. Bitter taste and slightly warm nature; it enters lung and large intestine meridians. Mouse intravenous injection LD₅₀25g/kg, yet intragastric LD₅₀It was 0.887 g/kg. Rat intravenous LD₅₀25g/kg, 8g/kg for intraperitoneal injection and 0.6g/kg for intragastric administration.

Exocarpium Citri rubrum, named as Chinese medicine. Is dried outer peel of Citrus reticulata Blanco of Rutaceae and its cultivar. Pungent and bitter with warm nature. It enters lung and spleen meridians. The functions are as follows: to regulate qi, relax middle energizer, dry dampness and resolve phlegm. The main treatment is as follows: can be used for treating cough with excessive phlegm, food stagnation, alcohol impairment, nausea, and oppression. Exocarpium Citri rubrum, named as Chinese medicine. Is dried outer peel of Citrus reticulata Blanco of Rutaceae and its cultivar. Harvesting after fruit ripening in late autumn and early winter, cutting off exocarp, and sun drying or shade drying. Pungent and bitter with warm nature. It enters lung and spleen meridians. The functions are as follows: to regulate qi, relax middle energizer, dry dampness and resolve phlegm. The main treatment is as follows: can be used for treating cough with excessive phlegm, food stagnation, alcohol impairment, nausea, and oppression. The book of medical science: tangerine peel, exocarpium Citri rubrum, pungent flavor can move transversely to dissipate nodulation and bitter flavor can move downward directly, is the key herb for promoting qi. For phlegm should be treated by the cap, it is necessary to regulate qi, and qi is good at self-healing, so it enters lung and spleen, and is mainly indicated for all kinds of phlegm diseases. Zhu Ru is used to treat hiccup and help Qing Pi to remove stagnant qi, and is combined with Bai Suo and Ma Huang to dispel food-qi, relieve alcoholism, stop vomiting and open chest and diaphragm stuffiness and plug, so it is pungent, bitter and descending in nature, and it is also used together with cang Zhu and Hou Po to calm stomach and excess, and it is also combined with Bai Su and Ma Huang to dispel food-qi, relieve alcoholism, stop vomiting and open chest and diaphragm stuffiness and plug.

Cassia twig, name of traditional Chinese medicine. Is the twig of Cinnamomum cassia Presl of the genus Lauraceae, Cinnamomum cassia. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, supporting yang, and regulating qi. It can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, water retention syndrome, and palpitation. Pungent and sweet in flavor and warm in nature; it enters heart, lung and bladder meridians. Chemical components: the product contains volatile oil, and cinnamic aldehyde as main ingredient. In addition, it also contains phenols, organic acids, polysaccharides, glycosides, coumarins, tannin, etc. The pharmacological action is as follows: the decoction of ramulus Cinnamomi and cinnamaldehyde have effects of lowering temperature and relieving fever. The ramulus Cinnamomi decoction and ethanol extractive solution have inhibitory effect on Staphylococcus aureus, Staphylococcus albus, Bacillus typhi, common pathogenic dermatophytes, Bacillus dysenteriae, Salmonella enteritidis, Vibrio cholerae, influenza virus, etc. Oleum Cinnamomi and cinnamaldehyde have effects of inhibiting tubercle bacillus, invigorating stomach, relieving gastrointestinal spasm, promoting urination, and strengthening heart. Cinnamic aldehyde has analgesic effect,Tranquilizing and anticonvulsive effects. The volatile oil has antitussive and expectorant effects. And (3) toxicological effects: LD with cassia twig water decoction taken by mice in daytime₅₀624.7mg/kg LD for nighttime drenching₅₀It was 773.6 mg/kg. Therefore, the cassia twig has obvious day and night difference on the toxic effect of the experimental mice, and the toxicity and the lethal effect in the day are obviously enhanced compared with the toxicity and the lethal effect at night.

Fresh ginger, named as traditional Chinese medicine. Is fresh rhizome of Zingiber officinale Rosc of Zingiberaceae. Has the effects of relieving exterior syndrome, dispelling cold, warming middle warmer, relieving vomit, warming lung, relieving cough, and removing toxic substance. Can be used for treating wind-cold type common cold, spleen and stomach cold syndrome, stomach cold emesis, cough due to lung cold, and fish and crab toxin. Pungent taste and warm nature; it enters lung, spleen and stomach meridians. Chemical components: the product contains volatile oil mainly comprising gingerol, alpha-zingiberene, beta-phellandrene, citral, aromatic alcohol, methyl heptenone, nonanal, alpha-borneol, etc., and pungent component gingerol. The pharmacological action is as follows: rhizoma Zingiberis recens has effects of promoting secretion of digestive juice, protecting gastric mucosa, resisting ulcer, protecting liver, promoting bile flow, resisting inflammation, relieving fever, resisting bacteria, relieving pain, and stopping vomiting. The alcohol extract can excite blood vessel movement center, respiratory center and heart. If you chew ginger, he can increase blood pressure. The ginger water extract has different degrees of inhibiting and killing effects on typhoid bacillus, vibrio cholerae, trichophyton violaceum and trichomonas vaginalis, and has the effects of preventing the hatching of blood sucking eggs and killing schistosome.

Lily bulb, name of traditional Chinese medicine. Is a fleshy scaly leaf of Lilium Brownnii F.E.Brownvar.viridulium baker or Lilium tenuifolium L.pulimum DC.of Lilium of Liliaceae. Has the effects of nourishing yin, moistening lung, clearing away heart-fire and tranquilizing mind. It is mainly used for treating yin deficiency dry cough, cough with hemoptysis, insomnia and palpitation due to yin deficiency with heat, and heart-lung yin deficiency internal heat syndrome due to lily disease. Sweet in taste and slightly cold in nature; it enters lung, heart and stomach meridians. Chemical components: the product contains phenolic glyceride, propionate derivative, phenolic glycoside, phenolic glyceride glycoside, steroid alkaloid, trace elements, starch, protein, fat, etc. The pharmacological action is as follows: the lily water extract has the functions of relieving cough and eliminating phlegm for experimental animals; can be used for treating toad asthma caused by antihistamine; the lily water extract also has the effects of strengthening, tranquilizing and resisting allergy; the lily water decoction and alcohol precipitation solution has the function of hypoxia resistance; can also be used for preventing leukopenia caused by cyclophosphamide.

Tuckahoe, name of traditional Chinese medicine. Is dried sclerotium of Wolf of Poriacos (Schw.) of Polyporaceae family. Yun Ling is called Yun Ling in Yunnan province, and is superior in quality. Has effects of inducing diuresis to alleviate edema, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, phlegm retention, diarrhea due to spleen deficiency, palpitation, and insomnia. Sweet and light taste, mild in nature; it enters heart, lung and spleen meridians.

The name of the Chinese medicine is seville orange flower. Is dried flower minel of Citrus aurantium L.var.amara Eng. Has effects of regulating qi-flowing, relieving chest stuffiness, and stimulating appetite. It can be used for treating chest and abdominal distention, nausea, and anorexia. Mild in nature, sweet and slightly bitter in taste. Chemical components: the leaf and flower of Citrus aurantium L.have aromatic oil content of about 0.2-0.4%, and the pericarp has oil content of about 1.5-2%. The oil comprises the following components: nerol, nerobdol, linalool, etc. about 20 types. Also contains multiple flavonoid glycosides; aurantiamarin, auranetin, heperidine, and the like. The pulp mainly contains citric acid and vitamin C. It is possible that putrescine is contained in the composition with a particular off-flavor. The foreign sour orange variety also contains dipentene, sabinene, myrcene and quinoline alkaloid. The seeds contain fatty oil: mainly comprising oleic acid, linoleic acid and palmitic acid, and a small amount of stearic acid. The pharmacological action is as follows: the seville orange flower herb contains various components of cardiac glycoside and non-cardiac glycoside, and is seen in medicine and food in many countries. The Chinese medicine is called herba Adonidis. It has effects in tonifying heart, promoting urination, tranquilizing mind, and slowing heart rate, and can be used for treating acute diseases and chronic cardiac insufficiency, and can reduce excitability of nervous system and hyperreflexia of spinal cord. It can be used for treating congestive heart failure, cardiac edema and atrial fibrillation, and can be used together with silver bromide for treating epilepsy.

Flos Lonicerae, wherein the flos Lonicerae is Lonicera Japonica of Lonicera of Caprifoliaceae and its congeneric plant, and its dried bud or flower with initial bloom. Honeysuckle is known as a good medicine for clearing heat and removing toxicity from old times. It is sweet and cold in nature and fragrant, sweet and cold in nature and clearing heat without hurting stomach, and the fragrance is thorough and can eliminate pathogens. The honeysuckle can disperse wind-heat and clear away blood toxin, and has obvious effect on various heat diseases such as fever, eruption, macula, sore and carbuncle due to heat toxin, sore throat and the like. Is cold in nature and sweet in taste, enters lung, heart and stomach meridians, has the effects of clearing away heat and toxic materials, resisting inflammation, tonifying deficiency and treating wind, and is mainly used for treating diseases such as distending pain, fever due to epidemic febrile disease, toxic heat, carbuncle and ulcer, tumor and the like. It has therapeutic effects on dizziness, thirst, hyperhidrosis, vexation, enteritis, bacillary dysentery, measles, pneumonia, encephalitis B, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle, furuncle, erysipelas, parotitis, and suppurative tonsillitis.

Kudzu root, name of Chinese traditional medicine. Is dried root of Ohwi of Pueraria lobata (Willd.) Ohwi of Pueraria of Leguminosae. Has the effects of expelling pathogenic factors from muscles, relieving fever, promoting eruption, promoting salivation, quenching thirst, invigorating yang, and relieving diarrhea. It can be used for treating fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency. Nature, flavor and meridian tropism: sweet and pungent in flavor and cool in nature; it enters spleen and stomach meridians.

Ageratum, academic name: agastacherugosa (fischer.et Mey.) o.ktze; also named: hexiang, cang Ji and shan Feng Zi belong to Labiatae family perennial herb of Labiatae family. Aromatic oil can be extracted from stem and leaf of herba Agastaches. The ground part can be used as a medicine, has mild nature, pungent and sweet taste, has the functions of relieving summer-heat, resolving dampness, harmonizing stomach, stopping vomiting and the like, and is mainly used for treating diseases such as summer-heat and dampness, headache and fever, chest distress and abdominal distension, vomiting, diarrhea and the like. Agastache rugosa is also rich in nutrients and trace elements. Its tender stem, leaf and seedling contain calcium, carotene, protein, cellulose and various minerals, so that it can be used as vegetable, not only is palatable, but also is a health-care product. Herba Agastaches in cold sauce is often eaten in summer, and can be used for preventing common cold and summer dampness, and caring skin. The stem and leaf of Agastache rugosa can be used as aromatic oil for food industry and cosmetic industry. Nature, flavor and meridian tropism: pungent and warm. It enters spleen, stomach and lung meridians. The functions and indications are as follows: fragrant, resolving turbidity, regulating the middle warmer, arresting vomiting, relieving exterior syndrome and clearing summer-heat. Can be used for treating damp obstruction in middle warmer, abdominal distention, emesis, summer-heat dampness exterior syndrome, early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, abdominal pain, emesis, diarrhea, nasosinusitis, and headache. Herba Agastaches has antibacterial effect, and can be used for removing halitosis, preventing infectious diseases, and as antiseptic. It is administered orally in summer by decocting herba Agastaches in porridge or making tea, and can be used for treating severe summer-damp disease, dampness obstruction of spleen and stomach, abdominal distention, physical weakness, nausea and emesis.

Apocynum venetum, named as traditional Chinese medicine. Apocynum Veneum L. [ Trachomotum venetum L. ], Woodson; leaves of Apocynumlancifolicum Russan. Has effects of suppressing liver yang, clearing heat, promoting diuresis, and tranquilizing mind. It can be used for treating dizziness, dysphoria, insomnia, convulsion, edema, dysuria, hematemesis, epistaxis, traumatic hemorrhage, and wind-heat type common cold due to hyperactivity of liver-yang and flaring-up of liver-fire. Sweet, slightly bitter and cool in nature. Chemical components: the dogbane leaf mainly contains flavonoid glycoside, phenolic substances, organic acids, amino acids, polyglycoside, tannin, sterol, steroidal sapogenin and triterpenes; the root contains cardiac glycosides, i.e. canadian glycoside, Convolvulus arvensis aglycone and K-Convolvulus arvensis glycoside-beta. The pharmacological action is as follows: 1. effects on the cardiovascular system: the dogbane leaf has the function of reducing blood pressure, but does not reduce normal blood pressure, and has the function of regulating the pressure of patients with low blood pressure; the herba Apocyni Veneti root has effects of tonifying heart, increasing myocardial contraction force, slowing down heart rate, and increasing coronary blood flow. 2. Effects on the central nervous system: folium Apocyni Veneti has tranquilizing and anticonvulsive effects. 3. Effects on the blood system: the folium Apocyni Veneti water extract can reduce serum total cholesterol value and serum triglyceride value without affecting lipid absorption of animals, and has effect of reducing serum total cholesterol greater than that of clofibrate. The dogbane leaf can also reduce the platelet aggregation rate and the number of platelets, and is beneficial to preventing and treating cardiovascular and cerebrovascular thrombotic diseases. 4. Impact on immune function: apocynum venetum has the effects of regulating organism immunity and enhancing organism immunity. 5. The virus inhibiting effect is as follows: apocynum venetum has certain inhibitory effect on rhinovirus and influenza virus infection. The apocynum venetum injection and the apocynum ephedra ketone aluminum salt have no direct inhibition effect on rhinovirus, but have obvious early treatment effect and slight prevention effect; has direct inhibition effect on influenza A virus. 6. Other functions are as follows: the apocynum venetum has selective inhibition effect on drug metabolizing enzyme of the liver, and can improve the detoxification function of the liver; has radioprotective, antiaging, genetic injury resisting, and diuretic effects.

Mint, name of traditional Chinese medicine. Is aerial part of Mentha haphallocalyxBriq. belonging to Mentha of Labiatae. Has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat type common cold, early stage epidemic febrile disease, wind-heat type headache, conjunctival congestion, lacrimation, sore throat, measles without adequate eruption, pruritus, stagnation of qi due to depression of liver, chest distress, and hypochondriac pain. Pungent taste and cool nature; it enters lung and liver meridians.

Yam, name of traditional Chinese medicine. Is rhizome of Dioscorea opposita Thunb of Dioscorea of Dioscoreaceae. Has effects of invigorating qi, nourishing yin, invigorating spleen, lung and kidney, and stopping leukorrhagia. It can be used for treating spleen deficiency, anorexia, asthenia, loose stool, diarrhea, cough and asthma due to lung deficiency, spermatorrhea, leukorrhagia, frequent micturition, internal heat, and diabetes. Sweet in taste and neutral in nature; it enters spleen, lung and kidney meridians. Chemical components: the product contains diosgenin, mucus, choline, starch, glycoprotein, free amino acids, vitamin C, amylase, etc. The pharmacological action is as follows: 1. effects on the digestive system: the rhizoma Dioscoreae has effects of stimulating small intestine movement and promoting evacuation of intestinal canal content. Can reduce intestinal canal tension caused by epinephrine, and rhizoma Dioscoreae can restore rhythm. 2. Impact on the immune system: rhizoma Dioscoreae has effects of enhancing cellular immunity and humoral immunity. 3. The anti-aging effect is as follows: 20% of yam or prepared rehmannia root, chrysanthemum, yam and achyranthes root mixture decoction is soaked in mulberry leaves and then dried in the shade, and has the function of anti-aging. 4. The function of reducing blood sugar is as follows: the yam can obviously reduce blood sugar, has the effects of preventing and treating diabetes, and can obviously resist the blood sugar rise caused by adrenalin and glucose. 5. In addition, yam has certain effects of promoting wound healing, resisting anoxia and the like.

Chinese medicine name of Chinese olive. Is dried mature fruit of Canarium album Raeusch of Terminalia of Combretaceae. Has the effects of clearing away heat and toxic materials, relieving sore throat and promoting fluid production. Can be used for treating swelling and pain of throat, cough, polydipsia, fish and crab poisoning. Sweet and sour in taste and mild in nature; it enters lung and stomach meridians. Chemical components: the fruit of the product contains protein, fat, carbohydrate, calcium, phosphorus, iron, ascorbic acid, etc.; the seed contains volatile oil and resinol. The pharmacological action is as follows: the Chinese olive extract has protective effect on hepatosis caused by the galactose amine; can also relieve the damage of carbon tetrachloride to liver. It can excite salivary glands to increase salivary secretion, so it is helpful for digestion. Compendium of materia Medica: "Shengjinye" can stop polydipsia and treat sore throat. When the throat juice is chewed, all fish and turtle toxins can be removed. ".

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

4-8 parts of dried orange peel, 8-12 parts of boat-fruited sterculia seed, 6-9 parts of purple perilla, 8-11 parts of rhodiola rosea, 8-11 parts of honey-fried licorice root, 13-25 parts of momordica grosvenori, 17-23 parts of houttuynia cordata, 4-8 parts of almond, 4-8 parts of exocarpium citri rubrum, 4-8 parts of cassia twig, 4-8 parts of ginger, 8-11 parts of lily, 11-14 parts of poria cocos, 3.5-4.5 parts of seville orange flower, 8-12 parts of honeysuckle, 11-13 parts of radix puerariae, 6-9 parts of ageratum, 6-9 parts of apocynum venetum, 4-5.5 parts of mint, 18-26 parts of Chinese yam and 5-8 parts of Chinese olive.

the traditional Chinese medicine composition comprises, by weight, 5 parts of dried orange peel, 10 parts of boat-fruited sterculia seed, 7 parts of purple perilla, 10 parts of rhodiola rosea, 10 parts of honey-fried licorice root, 20 parts of momordica grosvenori, 18 parts of houttuynia cordata, 5 parts of almond, 5 parts of exocarpium citri rubrum, 6 parts of cassia twig, 6 parts of ginger, 10 parts of lily, 13 parts of poria cocos, 4 parts of seville orange flower, 11 parts of honeysuckle, 12 parts of kudzu vine root, 7 parts of ageratum, 7 parts of apocynum venetum, 5 parts of mint, 23 parts of Chinese yam and 6 parts of Chinese olive.

A method for preparing a composition for treating viral influenza comprises the following steps:

selecting boat-fruited sterculia seed, purple perilla, rhodiola rosea, honey-fried licorice root, momordica grosvenori, heartleaf houttuynia herb, almond, red tangerine peel, cassia twig, ginger, lily, tuckahoe, seville orange flower, honeysuckle, kudzuvine root, apocynum venetum and Chinese olive according to a corresponding proportion, soaking, decocting, filtering, adding ground tangerine peel, wrinkled gianthyssop herb, mint and Chinese yam, mixing uniformly, drying, granulating and finishing to obtain a finished product.

Preferably, water is selected for soaking;

the soaking time is 40-65 minutes.

Preferably, the decoction temperature is 80-110 ℃.

Preferably, the decocting time is 30-75 minutes.

Preferably, the particle size of the pulverized tangerine peel, wrinkled giant hyssop, mint and Chinese yam powder is 30-50 μm.

Preferably, the finished product is in the form of granules.

Preferably, the finished particle size is no greater than 70 mm.

The invention has the beneficial effects that:

the invention provides a composition for treating viral influenza, which is prepared from dried orange peel, has warm nature, pungent taste and bitter taste, enters spleen channels, stomach channels and lung channels, regulates middle-jiao and reduces phlegm; boat-fruited sterculia seed, sweet in taste, cold in nature, capable of clearing lung and eliminating phlegm, relieving sore throat and easing up voice, and moistening intestines and relaxing bowels; purple perilla, slightly hot in nature, enters cold channel, relieves exterior syndrome, dispels cold, promotes qi circulation and relieves epigastric distention; rhodiola root, sweet in taste, cold in nature, capable of strengthening spleen and replenishing qi, and clearing lung and relieving cough; prepared licorice root, radix Glycyrrhizae Praeparata, harmonizing the recipe of the drugs, moistening the lung, removing toxicity, and harmonizing the effects of the other drugs; fructus momordicae clears away the lung-heat and relieves sore throat, and eliminates phlegm and stops coughing; the heartleaf houttuynia herb has the effects of clearing heat and removing toxicity, eliminating carbuncle and discharging pus; apricot kernel, bitter in taste, slightly warm in nature, can relieve cough and asthma; exocarpium Citri rubrum, pungent and bitter in flavor, warm in nature, dampness eliminating and phlegm resolving; cassia twig, pungent and sweet in flavor, warm in nature, and capable of warming and dredging channels and collaterals and inhibiting bacteria; ginger, pungent in flavor, warm in nature, relieving exterior syndrome, dispelling cold, warming lung, relieving cough, and removing toxic substance; lily, for nourishing yin and moistening lung; tuckahoe, Poria, inducing diuresis to alleviate edema, excreting dampness; the bitter orange flower has mild nature, sweet and slightly bitter taste, and can regulate qi and relieve chest stuffiness; honeysuckle flower, cold in nature, sweet in taste, enters lung, heart and stomach channels, disperses wind-heat, clears blood toxin and resists inflammation; kudzu root, sweet and pungent in flavor, cool in nature, and capable of expelling pathogenic factors from muscles and skin and reducing fever; ageratum, fragrant, turbid, middle warmer regulating and vomiting stopping; bluish dogbane, sweet in taste, slightly bitter, cool in nature, calms down liver yang, clears heat and induces diuresis; mint, dispersing wind-heat, refreshing mind; the Chinese yam has the effects of supplementing qi, nourishing yin and tonifying spleen, lung and kidney; the Chinese olive has the effects of clearing heat, removing toxicity and relieving sore throat, and after all the raw materials are reasonably mixed, the effects of clearing fire, diminishing inflammation, warming spleen and stomach, dispelling cold, eliminating dampness, removing toxicity, inhibiting bacteria, diminishing inflammation and improving immunity are achieved.

The preparation method of the composition is simple and easy to operate, can ensure the precipitation rate of all effective components, and the prepared finished product is granules, and also aims to improve the absorption rate of patients on the effective components. The composition has no adverse side effects and irritation.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

selecting 5g of boat-fruited sterculia seed, 5g of perilla, 6g of rhodiola rosea, 6g of honey-fried licorice root, 10g of momordica grosvenori, 15 g of houttuynia cordata, 3 g of almond, 3 g of exocarpium citri rubrum, 3 g of cassia twig, 3 g of ginger, 6g of lily, 10g of poria cocos, 3 g of seville orange flower, 6g of honeysuckle, 9 g of kudzu vine root, 5g of apocynum venetum and 4.5 g of Chinese olive according to a corresponding proportion, soaking for 40 minutes, decocting for 75 minutes at 80 ℃, filtering, adding 3 g of dried orange peel, 5g of wrinkled gianthyssop herb, 3 g of mint and 15 g of Chinese yam which are ground into powder with the particle size of 30 mu m, uniformly mixing, drying, granulating and finishing to obtain a finished product with the particle size of not more than 70 mm.

Example 2:

selecting 15 g of boat-fruited sterculia seed, 10g of perilla, 12 g of rhodiola rosea, 12 g of honey-fried licorice root, 30 g of momordica grosvenori, 25g of houttuynia cordata, 10g of almond, 10g of red tangerine peel, 9 g of cassia twig, 9 g of ginger, 12 g of lily, 15 g of poria cocos, 5g of seville orange flower, 15 g of honeysuckle, 15 g of kudzu vine root, 10g of apocynum venetum and 9 g of Chinese olive according to a corresponding proportion, soaking for 65 minutes, decocting for 30 minutes at 110 ℃, filtering, adding 10g of dried orange peel, 10g of wrinkled gianthyssop herb, 6g of mint and 30 g of Chinese yam which are ground into powder with the particle size of 50 mu m, uniformly mixing, drying, granulating and finishing to obtain a finished product with the particle size of not more than 70 mm.

Example 3:

selecting 8g of boat-fruited sterculia seed, 6g of perilla, 8g of rhodiola rosea, 8g of honey-fried licorice root, 13 g of momordica grosvenori, 17 g of houttuynia cordata, 4 g of almond, 4 g of exocarpium citri rubrum, 4 g of cassia twig, 4 g of ginger, 8g of lily, 11 g of poria cocos, 3.5 g of seville orange flower, 8g of honeysuckle, 11 g of kudzu root, 6g of apocynum venetum and 5g of Chinese olive according to a corresponding proportion, soaking for 40 minutes, decocting for 75 minutes at 80 ℃, filtering, adding 4 g of dried orange peel, 6g of wrinkled gianthyssop herb, 4 g of mint and 18 g of Chinese yam which are ground into powder with the particle size of 30 mu m, uniformly mixing, drying, granulating and finishing to obtain a finished product with the particle size of not more than 70 mm.

Example 4:

selecting 12 g of boat-fruited sterculia seed, 9 g of purple perilla, 11 g of rhodiola rosea, 11 g of honey-fried licorice root, 25g of momordica grosvenori, 23 g of houttuynia cordata, 8g of almond, 8g of red tangerine peel, 8g of cassia twig, 8g of ginger, 11 g of lily, 14 g of poria cocos, 4.5 g of seville orange flower, 12 g of honeysuckle flower, 13 g of kudzu root, 9 g of apocynum venetum and 8g of Chinese olive according to a corresponding proportion, soaking for 65 minutes, decocting for 30 minutes at 110 ℃, filtering, adding 8g of dried orange peel, 9 g of wrinkled gianthyssop herb, 5.5 g of mint and 26 g of Chinese yam which are ground into powder with the particle size of 50 mu m, uniformly mixing, drying, granulating and finishing to obtain a finished product with the particle size of not more than 70 mm.

Example 5:

selecting 10g of boat-fruited sterculia seed, 7g of perilla, 10g of rhodiola rosea, 10g of honey-fried licorice root, 20 g of momordica grosvenori, 18 g of houttuynia cordata, 5g of almond, 5g of red tangerine peel, 6g of cassia twig, 6g of ginger, 10g of lily, 13 g of poria cocos, 4 g of seville orange flower, 11 g of honeysuckle, 12 g of kudzu vine root, 7g of apocynum venetum and 6g of Chinese olive according to a corresponding proportion, soaking for 65 minutes, decocting for 30 minutes at 110 ℃, filtering, adding 5g of dried orange peel, 7g of wrinkled gianthyssop herb, 5g of mint and 23 g of Chinese yam which are ground into powder, uniformly mixing, drying, granulating and finishing to obtain a finished product with the particle size of not more than 70 mm.

Soaking semen Scaphii Lychnophori, Perillae herba, radix Rhodiolae, radix Glycyrrhizae Preparata, fructus Siraitiae Grosvenorii, herba Houttuyniae, semen Armeniacae amarum, exocarpium Citri rubrum, ramulus Cinnamomi, rhizoma Zingiberis recens, Bulbus Lilii, Poria, bitter Citrus immature flower, flos Lonicerae, radix Puerariae, herba Apocyni Veneti and fructus Canarii albi with water.

The administration mode is as follows: three times a day, one bag each time, 10 g/bag.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The composition for treating viral influenza is characterized by being prepared from the following raw materials in parts by mass:

2. The composition for treating viral influenza according to claim 1, wherein the composition is prepared from the following raw materials in parts by mass:

3. The composition for treating viral influenza according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. A method of preparing a composition for treating a viral cold according to any one of claims 1 to 3, comprising the steps of:

5. The method for preparing a composition for treating viral influenza according to claim 4, wherein the soaking is carried out with water;

the soaking time is 40-65 minutes.

6. The method of claim 4, wherein the decocting temperature is 80-110 ℃.

7. The method of claim 6, wherein the decocting is carried out for a period of 30-75 minutes.

8. The method for preparing a composition for treating viral influenza according to claim 4, wherein the particle size of the pulverized tangerine peel, wrinkled giant hyssop, mint and Chinese yam is 30-50 μm.

9. The method of claim 4, wherein the composition is in the form of a granule.

10. The method of claim 9, wherein the finished granules have a particle size of no greater than 70 mm.