CN104161977B - It is a kind of to be used to prevent and treat Chinese medicine composition of infectious coryza of chicken and preparation method thereof - Google Patents
It is a kind of to be used to prevent and treat Chinese medicine composition of infectious coryza of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken and preparation method thereof, belong to technical field of Chinese medicine for animals.The Chinese medicine composition is mainly made up of the bulk drug of following parts by weight：20~25 parts of the Radix Astragali, 20~25 parts of safflower, 15~20 parts of Herba Andrographitis, 15~20 parts of the fruit of Chinese wolfberry, 15~20 parts of the fleece-flower root, 15~20 parts of radix scutellariae, 15~20 parts of barrenwort, 10~20 parts of the bark of ash, 10~20 parts of the fruit of glossy privet, 10~20 parts of rhizoma atractylodis, 8~15 parts of Radix Codonopsis, 8~15 parts of the tuber of dwarf lilyturf, 30~35 parts of folium isatidis, 15~25 parts of Chinese violet, 15~18 parts of Radix Angelicae Sinensis, 5~10 parts of the coptis.Above-mentioned all medicines are according to monarch principle composition of prescription, and the effects such as all medicines share plays clearing heat and detoxicating, anti-inflammation, improves immunity of organisms altogether is mainly used in treating infectious coryza of chicken.
Description
Technical field
It is used to preventing and treating the Chinese medicine composition of infectious coryza of chicken present invention relates particularly to a kind of, and the Chinese medicine composition
Preparation method, belongs to technical field of Chinese medicine for animals.
Background technology
Infectious coryza of chicken is the acute respiratory disease of the chicken as caused by haemophilus paragallinarum.Cardinal symptom is nasal cavity
With Dou Fayan, have a running nose, facial swelling and sneeze.This disease betides the chicken at various ages, and aged chicken infection is more serious.7d
Chick, can often occur this disease with artificial infection germ in nasal cavity, and 3~4d chick then slightly resistance.4 week old were to 3 years
Chicken it is susceptible, but have individual otherness.The week old chicken of artificial challenge 4~8 has the typical symptom of 90% appearance.13 week old and big
Then 100% infection of a little chickens.In older chicken, incubation period is shorter, and the course of disease is long.This disease is distributed in the whole world, can cause infection
The laying rate of laying hen be generally reduced 10~40%, Young cock weightening is stagnated and the increase of eliminate chicken quantity, is brought sternly to aquaculture
The economic loss of weight.
At present, treatment infectious coryza of chicken generally uses sulfa drugs, but these medicines not only have side effect, and
Easily produce drug resistance or cause medicament residue, potential hazard is carried out to mankind's health care belt.With it is safe and free of toxic and side effects, without residual
The Chinese herbal and crude drugs preparations stayed suspected of preventing and treating infectious coryza of chicken without providing new thinking, but Chinese herbal medicine in the market
Preparation is remained the shortcomings of bioavilability is low, clinical effectiveness is not good.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken.
Meanwhile, the present invention also provides a kind of preparation method for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken, is mainly made up of the bulk drug of following parts by weight：It is yellow
20~25 parts of stilbene, 20~25 parts of safflower, 15~20 parts of Herba Andrographitis, 15~20 parts of the fruit of Chinese wolfberry, 15~20 parts of the fleece-flower root, radix scutellariae 15~
20 parts, 15~20 parts of barrenwort, 10~20 parts of the bark of ash, 10~20 parts of the fruit of glossy privet, 10~20 parts of rhizoma atractylodis, 8~15 parts of Radix Codonopsis, Mai Men
8~15 parts of winter, 30~35 parts of folium isatidis, 15~25 parts of Chinese violet, 15~18 parts of Radix Angelicae Sinensis, 5~10 parts of the coptis.
It is preferred that, a kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken, mainly by the bulk drug of following parts by weight
Composition：25 parts of the Radix Astragali, 20~22 parts of safflower, 15~18 parts of Herba Andrographitis, 18~22 parts of the fruit of Chinese wolfberry, 15~20 parts of the fleece-flower root, radix scutellariae
18 parts, 15~20 parts of barrenwort, 12~15 parts of the bark of ash, 15 parts of the fruit of glossy privet, 12~18 parts of rhizoma atractylodis, 8~15 parts of Radix Codonopsis, the tuber of dwarf lilyturf 8
~15 parts, 35 parts of folium isatidis, 15~20 parts of Chinese violet, 15~18 parts of Radix Angelicae Sinensis, 8 parts of the coptis.
A kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken, includes the auxiliary material of following parts by weight：Sucrose 70~
90 parts plus beneficial 80~90 parts of powder.
There is choosing, a kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken includes the auxiliary material of following parts by weight：Sugarcane
80 parts of sugar plus beneficial 85 parts of powder.
Each bulk drug effect is summarized as follows in the present invention：
The Radix Astragali：For pulse family Astragalus astragalus mongolicus and the root of Astragalus membranacus；It is different containing saponin component such as astragalin
Flavone component such as calycosin, fatty acid such as palmitic acid and linoleic acid, polysaccharide such as astragalus polyose, heteroglycan etc., and
Nearly 20 various trace elements；Radix Astragali nature and flavor are sweet, temperature, return lung, the spleen channel；Can benefiting qi and raising yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, eliminating toxic
Myogenic；Cure mainly the disease of all Qi and blood deficiencies, such as splenasthenic diarrhea, cough due to deficiency of the lung, prolapse of the anus, metroptosis, spontaneous perspiration, night sweat, oedema, blood
Numbness, ulcer is difficult to burst or burst for a long time and does not holds back；Modern pharmacology proves that the Radix Astragali can influence organism metabolism to have antioxidation, moreover it is possible to anti-blood
Bolt, antiviral, Antiarthritic, anticancer, anti-inflammatory and antalgic, protection cardio-cerebrovascular and promotion hematopoiesis function.
Safflower：For the flower of composite family safflower platymiscium safflower；Contain flavone compound such as carthamic acid, preceding carthamic acid, safflower
Safflor yellow A, B etc., Polyphenols such as chlorogenic acid, caffeic acid, catechol etc. also plant volatile ingredient such as cinnamic acid first containing more than 80
Ester, cloves alkene, cloves alkene epoxides etc., and 16 kinds of amino acid such as lysines, fatty acid for example palmitic acid, myristic acid,
Laurate, oleic acid etc., separately containing various active compositions such as safflower polysaccharides；Nature and flavor are pungent, temperature, the thoughts of returning home, Liver Channel；Can invigorate blood circulation, dispel
The stasis of blood is relieved pain；Cure mainly blood stasis, dysmenorrhoea, postpartum stasis stomachache, chest impediment and cardialgia, lumps in the chest and abdomen, traumatic injury, arthralgia, in
Windage yaw paralysis etc.；Modern pharmacology proves that safflower has anticoagulation, anti-inflammatory, antioxidation etc..
Herba Andrographitis：For the herb of Acanthaceae punching nelumbium Herba Andrographitis；Leaf contains Diterpenes such as andrographolide etc., yellow
Ketone such as oroxylin A, wogonin, also containing Polyphenols such as caffeic acid, chlorogenic acid etc., it is yellow that root contains flavonoids such as Herba Andrographitis
Ketone, andrographin glycosides A, B, C, D, E and F, also containing the various active composition such as α- Sitosterol；It is bitter in taste, contain, it is the thoughts of returning home, lung, big
Intestines, bladder warp；Can clearing heat and detoxicating, purging intense heat, eliminating dampness；Cure mainly anemopyretic cold, warm disease heating, cough with lung heat, pertussis, lung carbuncle, pharynx
Larynx swells and ache, gastropyretic toothache, acute bacillary dysentery, jaundice with damp-heat pathogen, sore carbuncle swells etc.；It is antipyretic, anti-that modern pharmacology proves that Herba Andrographitis has
Inflammation, anticancer, D-dimer, antithrombotic, hepatic cholagogic, decompression, antioxidant protection Endothelial Cell Function etc..
The fruit of Chinese wolfberry：For the fruit that the fruit of Chinese wolfberry is Solanaceae Lycium lycium barbarum；Contain Allylamines, polysaccharide, brain glycosides
The yellow matter of fat, ursolic acid, alkaloid, p-Coumaric Acid, daucosterol, carrotene, atropine, hyoscyamine, maize, wintercherry fruit
The various active composition such as red pigment, kryptoxanthin, vitamin C；Nature and flavor are sweet, flat, Return liver, kidney, lung channel；Can nourishing the liver, nourshing kidney, moistening lung；It is main
Caused by liver and kidney deficiency is controlled, is had a dizzy spell, visually unclear, soreness and weakness of waist and knees, cough due to consumptive disease etc.；Modern pharmacology proves that the fruit of Chinese wolfberry has and delayed
The effect such as aging, anti-fatty liver, regulation blood fat and blood glucose, promotion hematopoiesis function, moreover it is possible to adjust body's immunity, effectively suppress
Tumour growth and cell mutation etc..
The fleece-flower root：For the root tuber of the polygonaceae arsesmart fleece-flower root；Contain anthraquinone analog compound such as rheum emodin, Chrysophanol, big
The various active compositions such as yellow phenol anthrone, fleece-flower root C prime, piceid；It is bitter in taste, sweet, puckery, tepor, Return liver, the heart, kidney channel；Energy
Nourishing the blood and yin, relax bowel, wind-dispelling, removing toxic substances；Cure mainly Light-headedness, palpitaition, insomnia, soreness and weakness of waist and knees, poliosis, tinnitus, intestines
Dry constipation, chronic malaria body void, rubella itch, sore carbuncle, scrofula etc.；Modern pharmacology proves that the fleece-flower root has reducing blood lipid, anti-artery congee
Sample hardening, immune enhancing, anti-aging, anti-genetic damage, anti-inflammatory, analgesic activity etc..
Radix scutellariae：For the root of lamiaceae labiatae scutellaria plant radix scutellariae；Contain flavone compound such as baicalein, neobaicalein, Huang
A kind of reed mentioned in ancient books glycosides, wogonoside etc., also containing plurality of active ingredients such as cupreol, campesterol and stigmasterol；It is bitter in taste, cold, return lung,
The heart, liver, courage, large intestine channel；Can clearing heat-fire, eliminating dampness removing toxic substances, hemostasis, it is antiabortive；Cure mainly lung heat cough and asthma, high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility
Headache, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis, fetal movement with fever, carbuncle swells furunculosis etc.；Modern pharmacology proves radix scutellariae
With antimicrobial, platelet aggregation-against and anti-freezing, anti-oxidant, anticancer, reduce blood pressure with diuresis, effect for reducing blood fat etc..
Barrenwort：For barberry gram barrenwort barrenwort, Epimedium sagittatum, E. wushanense T. S. Ying, korean epimedium herb, soft
Stem, the leaf of hair barrenwort etc.；Its aerial part contains flavonoids such as epimedium flavone glycosides, epimedium flavone time glycosides I, and inorganic
The element such as various active composition such as potassium, calcium；Nature and flavor acrid, sweet, warm, return kidney, Liver Channel；Energy tonifying kidney and strengthening yang, strengthening the muscles and bones, wind-dispelling are removed
It is wet；Cure mainly kidney deficiency cough and asthma, soreness and weakness of waist and knees, arthralgia pain due to rheumatism etc.；Modern pharmacology proves that barrenwort has anti-aging, regulation immune
Function, prevent and treat osteoporosis, promote union, antitumor action etc..
The bark of ash：For the bark of Oleaceae Chinese ash platymiscium great Ye Ash, sharp leaf Ash, Chinese ash and Pax ash；Contain horse-chestnut
Bark glycosides, aesculetin, also containing the Coumarins such as various active composition such as aesculetin, fraxetin and alkaloid；Nature and flavor
It is bitter, puckery, tremble with fear, Return liver, courage, large intestine channel；Can heat-clearing and damp-drying drug, clear liver and improve vision；Cure mainly damp-heat dysentery, red eye, swell pain, lung heat asthma cough
Cough；Modern pharmacology proves that the bark of ash has antibacterial, cough-suppressing phlegm-dispelling functions etc..
The fruit of glossy privet：For the fruit of Oleaceae glossy privet platymiscium glossy privet；Contain triterpenes such as oleanolic acid, acetyl olive
Acid, ursolic acid, acetyl ursolic acid, phenolic glycoside class such as p-hydroxyphenylethanol, Syring vulgaris phenolic glycoside etc., the iridoid glycosides such as fruit of glossy privet
Glycosides, oleuropein, different nuzhenide etc., also containing flavonoids such as racemic eriodictyol, Quercetin etc., and aliphatic acid such as palm
Acid, oleic acid etc., phospholipid such as lysophosphatidyl choline, phosphatidyl-ethanolamine etc., the various active such as volatile oil such as thioacetone into
Point；Nature and flavor sweet, bitter, cold, returns liver and kidney channel, can tonify the liver and kidney, clearind deficient heat, improving eyesight；Cure mainly Light-headedness, soreness and weakness of waist and knees, tinnitus,
Poliosis, osteopyrexia and fever etc.；Modern pharmacology proves that the fruit of glossy privet has anti-inflammatory, hypoglycemic, liver protection, antimutagenesis etc..
Rhizoma atractylodis：For composite family rhizoma atractylodis platymiscium Atractylis lancea, Atractylis chinensis, atractylodes japonica rhizome；Contain volatile oil such as β-olive
Alkene, chamigrene, cloves alkene, elemene etc., the various active composition such as hemiterpene glycoside, ene-alkyne class, also containing cobalt, chromium, copper, manganese,
The inorganic elements such as molybdenum；Nature and flavor are pungent, hardship, temperature, returns spleen, stomach, Liver Channel；Can drying damp and strengthening spleen, wind-damp dispelling, improving eyesight；Cure mainly the spleen and stomach being stranded by dampness, it is tired
Idle thermophilic sleeping, feeling of stuffiness in chest abdominal distension, poor appetite, vomiting and diarrhea, phlegm and retained fluid, wet wet swollen, exterior syndrome folder, head body weight pain, the wet victory of bi Zheng, podomere acid
Pain is weighed；Modern pharmacology proves that rhizoma atractylodis have anti anoxia, diuresis, anti-arrhythmia, antibacterial, antivirus action etc..
Radix Codonopsis：For campanulaceae of the genus codonopsis Radix Codonopsis, codonopsis pilosula var. modesta, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, gray wool party
The root of ginseng；Contain carbohydrate such as fructose, synanthrin, polysaccharide and 4 kinds of heteroglycan CP1、CP2、CP3、CP4, glycoside such as syringin, n-hexyl-
β-glucopyranoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component such as choline, loline etc.,
Also containing various active compositions such as syringaldehyde, vanillic acid, pyromucic acid, atractyloides I, II；Radix Codonopsis nature and flavor are sweet, put down, returns spleen,
Lung channel；Can strengthening the spleen and tonifying the lung, nourishing generate fluid；Cure mainly weakness of the spleen and the stomach, anorexia and loose stool, limbs fatigue, the deficiency syndrome of the lung breath with cough, shortness of breath spontaneous perspiration, gas
Blood two loses all cards；Modern pharmacology prove Radix Codonopsis have enhancing physical stress ability, enhancing body's immunity, anti-aging,
Antiulcer, antitumor booster action etc..
The tuber of dwarf lilyturf（The tuber of dwarf lilyturf）：For the Liliaceae Ophiopogon plant tuber of dwarf lilyturf or the root tuber of dwarf lilyturf；Contain the saponins such as tuber of dwarf lilyturf
Saponin(e, high isoflavonoid class such as methyl ophiopogon flavonoid, volatile oil etc.；Tuber of dwarf lilyturf nature and flavor are sweet, slight bitter, are slightly cold, return lung, stomach, the heart
Through；Can nourishing Yin and moistening lung, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire；Dryness of the lung dry cough is cured mainly, lung carbuncle, deficiency of Yin overstrain cough, injury thirst is quenched one's thirst, vexed
Insomnia, has sore throat, dry constipation of intestines etc.；Modern pharmacology proves the tuber of dwarf lilyturf to cardiovascular system, immunologic function, gastrointestinal motility work(
Energy etc. produces influence, also with antibacterial, anti-arrhythmia, hypoglycemic, removing free radical, anti-aging, resisting oxygen lack etc..
Folium isatidis：For the leaf of Cruciferae woaded blue platymiscium woaded blue；Contain indigo, woaded blue glycosides, indigo red, rosasterol etc.
Plurality of active ingredients；It is bitter in taste, tremble with fear；The thoughts of returning home, stomach, liver, lung channel；Can clearing heat and detoxicating, blood cooling and ecchymoses removing；Warm heat disease hyperpyrexia is cured mainly to be tired of
Yearningly, coma, macula is spitted blood, bleeding from five sense organs or subcutaneous tissue, jaundice, rush down dysentery, erysipelas, larynx numbness, aphtha, mumps etc.；Modern pharmacology proves folium isatidis tool
There is the effect such as resisting pathogenic microbes, antiendotoxin, anti-oxidant.
Chinese violet：For the herb of Violaceae Viola Chinese violet；Contain palmitic acid, P-hydroxybenzoic acid, anti-
The various active composition such as formula hydroxycinnamic acid；Nature and flavor bitter, acrid, cold, the thoughts of returning home, Liver Channel；Can clearing heat and detoxicating, eliminating dampness cool blood；Cure mainly
Furunculosis ulcer, erysipelas, acute mastitis, acute appendicitis, scrofula, damp-heat dysentery, red eye, swell pain etc.；It is anti-that modern pharmacology proves that Chinese violet has
Pathogenic microorganism effect etc..
Radix Angelicae Sinensis：For the root of Umbelliferae archangel Radix Angelicae Sinensis；Containing a variety of volatile oil and organic acid, also containing kind more than 20
Inorganic elements and polysaccharide constituents；Nature and flavor are sweet, pungent, hardship, temperature, Return liver, the heart, the spleen channel；Energy replenishing and activating blood, menstruction regulating and pain relieving moisturizes cunning
Intestines；The all cards of the deficiency of blood are cured mainly, irregular menstruation, Amenorrhea, dysmenorrhoea , Disorder lumps in the abdomen knot gathers, uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestinal dryness
Just it is difficult, weight, ulcer sores, injury from falling down etc. after dysentery characterized by blood in the stool；Modern pharmacology proves that Radix Angelicae Sinensis can influence blood and hemopoietic system, has
Reducing blood lipid, anti arteriosclerosis, radioresistance, antitumor, anti-inflammatory and antalgic and injury-resistance etc..
The coptis：For the rhizome of the Ranunculaceae coptis plant coptis, the triangle leaf coptis or rhizoma coptidis teetoidis；Containing alkaloids such as
The plurality of active ingredients such as jamaicin, coptisine, epiberberine, obakunone；It is bitter in taste, cold, the thoughts of returning home, liver, stomach, large intestine channel；Can be clear
Hot purging intense heat, eliminating dampness, removing toxic substances；Cure mainly pyreticosis heresy and enter the hyperpyrexia, agitation, delirium or excess heat of the heart channel of Hang-Shaoyin and compel the hematemesis of blood absurd shape, damp and hot chest
Ruffian, diarrhea, dysentery, the vexed insomnia of heart-fire hyperactivity, gastropyretic vomiting, rapid digestion of food and polyorexia, irascibility red eye, swell pain, and pathopyretic ulcer,
Serious case of furuncle septicemia, swelling and aching of gum, aphthae etc.；Modern pharmacology prove the coptis have antimicrobial, disease-resistant protozoon, it is antiviral,
Anti-arrhythmia, antiulcer, antitumor, antiinflammatory action etc..
A kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken, solution can be prepared into using conventional method, is dissipated
The Chinese herbal medicine formulation such as agent, granule, soluble powder, pre-mixing agent, tablet, capsule, parenteral solution, wherein with parenteral solution and particle
Agent is preferred, and the present invention provides the preparation method of a kind of parenteral solution and granule respectively.
A kind of preparation method for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, and filtration merges filtrate twice
And heat concentration, be then cooled to 40~60 DEG C it is standby；
（2）In step（1）Concentrate in add 2~3% enzyme preparation, it is standby after standing；
（3）By step（2）Medicine liquid heating after standing is decocted 20~30 minutes, adds the pure of 1.5~2.5 times of medicine liquid volumes
Change water, be again heated to 60~80 DEG C, add the acetum containing 1% chitosan for accounting for medicine liquid volume 8~12%, stirring takes after standing
Supernatant, regulation solution ph is 6.5~7.5, filtering, filling, sterilizing, thus obtaining the product after concentration.
The step（1）Middle first time, which decocts, Jia 8~10 times of amount water, decocts 1~2 hour, and second of decoction Jia 6~and 8 times
Water is measured, is decocted 0.5~1.5 hour.
The step（1）In be filtered into four layers of gauze.
The step（1）In to be concentrated into the ratio of medicine liquid volume and crude drug be 1:1.
The step（2）In enzyme preparation by mass ratio be cellulase:Pectase:Protease=2:1:1 component group
Into.
The step（2）The time of middle standing is 12 hours.
The step（3）The time of middle standing is 12 hours.
The step（3）In be concentrated into the 1/3~1/2 of medicine liquid volume.
The step（3）In be filtered into 0.45 micron membrane filter.
The usage and dosage of parenteral solution is：It is subcutaneously injected, every 0.5ml 1 times a day, is used in conjunction 7.
A kind of preparation method for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, and filtration merges filtrate twice
And heating is concentrated into the thick paste that relative density at 65~75 DEG C is 1.15~1.20, is cooled to room temperature standby；
（2）In step（1）Thick paste in add concentration be 80~95% ethanol to alcohol content be 45~50%, mistake after standing
Filter, ethanol is recovered under reduced pressure, and to obtain decoction standby；
（3）In step（3）Decoction in add mixing sucrose and plus beneficial powder, parboiling stirs evenly, will after spray drying
Pellet through sieves, then be dried in vacuo and produce.
The step（1）Middle first time, which decocts, Jia 8~10 times of amount water, decocts 1~2 hour, and second of decoction Jia 6~and 8 times
Water is measured, is decocted 0.5~1.5 hour.
The step（1）In be filtered into four layers of gauze.
The step（2）The time of middle standing is 12 hours.
The step（3）Middle sieving was 32 mesh sieves.
The step（4）In vacuum drying temperature be 45~60 DEG C, drying time be 1.5~2.5 hours.
The usage and dosage of granule is：Per 500g feeds addition granule 1g, daily 3~4 times, it is used in conjunction 7.
Beneficial effects of the present invention：
The present invention is using the Radix Astragali, safflower, Herba Andrographitis, the fruit of Chinese wolfberry, the fleece-flower root, radix scutellariae, barrenwort, the bark of ash, the fruit of glossy privet, grey
Art, Radix Codonopsis, the tuber of dwarf lilyturf, folium isatidis, Chinese violet, Radix Angelicae Sinensis, the coptis totally 16 taste pure natural Chinese herbal medicine, medicine source extensively, with nonreactive
The property of medicine, toxic side effect are small, be difficult in meat produce hazard residue the features such as, its effective ingredient except directly participation antibacterial
Outside, moreover it is possible to excite or strengthen the specificity and non-specific immune function of body, there is notable treatment to preventing and treating infectious coryza of chicken
Effect.In addition, protein, carbohydrate, fat, starch, trace element, vitamin contained in Chinese herbal medicine etc., can directly provide chicken
Only grow required nutriment, while the irritability of livestock can also be reduced.
All medicines are according to monarch principle composition of prescription in the present invention, wherein, the Radix Astragali, Herba Andrographitis, radix scutellariae, folium isatidis are monarch
Medicine, with clearing heat and detoxicating, antimicrobial and anti-inflammation efficacy, the bark of ash, Chinese violet, Radix Angelicae Sinensis, the coptis are ministerial drug, with heat-clearing and damp-drying drug, purging intense heat
Detoxicating functions, the fruit of Chinese wolfberry, the fleece-flower root, barrenwort, the fruit of glossy privet, rhizoma atractylodis, Radix Codonopsis, the tuber of dwarf lilyturf are adjutant, with dispelling wind and eliminating dampness, strengthening tendons
Key bone effect, safflower is makes medicine, with invigorate blood circulation, stasis-dispelling and pain-killing effect, all medicines share play altogether clearing heat and detoxicating, anti-inflammation,
The effect of improving immunity of organisms, is mainly used in treating infectious coryza of chicken.
The present invention will be prepared into parenteral solution or granule, method letter for preventing and treating the Chinese medicine composition of infectious coryza of chicken
It is single, easy to operate, and the parenteral solution character prepared is stable, easy to use, bioavilability is high, can significantly improve immunity of organisms,
Strengthen body resistance against diseases, there is good prophylactic-therapeutic effect to infectious coryza of chicken, can clinically extensive use.
Embodiment
Following embodiments are only described in further detail to the present invention, but do not constitute any limitation of the invention.
Embodiment 1
It is used for the Chinese medicine composition for preventing and treating infectious coryza of chicken in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：25 parts of the Radix Astragali, 20 parts of safflower, 15 parts of Herba Andrographitis, 18 parts of the fruit of Chinese wolfberry, 15 parts of the fleece-flower root, 18 parts of radix scutellariae, 15 parts of barrenwort, the Qin
12 parts of skin, 15 parts of the fruit of glossy privet, 12 parts of rhizoma atractylodis, 8 parts of Radix Codonopsis, 8 parts of the tuber of dwarf lilyturf, 35 parts of folium isatidis, 15 parts of Chinese violet, Radix Angelicae Sinensis 15
Part, 8 parts of the coptis.
It is used for the preparation method for preventing and treating the Chinese medicine composition of infectious coryza of chicken in the present embodiment, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, decocted for the first time plus 8 times of amounts
Water, is decocted 1 hour, second decocts plus 8 times of amount water, decocts 0.5 hour, with four layers of filtered through gauze, merges filtrate twice and add
It is 1 that heat, which is concentrated into medicine liquid volume and the ratio of crude drug,:1, be then cooled to 60 DEG C it is standby；
（2）In step（1）Concentrate in add 2%（Quality percent by volume）Enzyme preparation, described enzyme preparation is by matter
Amount is than being cellulase:Pectase:Protease=2:1:1 component composition, it is standby after then standing 12 hours；
（3）By step（2）Medicine liquid heating after standing is decocted 20 minutes, adds the purified water of 2 times of medicine liquid volumes, is reheated
To 80 DEG C, the dilute acetic acid solution containing 1% chitosan for accounting for medicine liquid volume 8% is added（The concentration of dilute acetic acid solution is 1%）, after stirring
12 hours are stood, supernatant is taken, regulation solution ph is 6.5, is concentrated into the 1/3 of medicine liquid volume, then crosses 0.45 micron membrane filter,
Filling, sterilizing, thus obtaining the product.
Embodiment 2
It is used for the Chinese medicine composition for preventing and treating infectious coryza of chicken in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：25 parts of the Radix Astragali, 22 parts of safflower, 18 parts of Herba Andrographitis, 22 parts of the fruit of Chinese wolfberry, 20 parts of the fleece-flower root, 18 parts of radix scutellariae, 20 parts of barrenwort, the Qin
15 parts of skin, 15 parts of the fruit of glossy privet, 18 parts of rhizoma atractylodis, 15 parts of Radix Codonopsis, 15 parts of the tuber of dwarf lilyturf, 35 parts of folium isatidis, 20 parts of Chinese violet, Radix Angelicae Sinensis 18
Part, 8 parts of the coptis.
It is used for the preparation method for preventing and treating the Chinese medicine composition of infectious coryza of chicken in the present embodiment, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, decocted for the first time plus 10 times of amounts
Water, is decocted 1.5 hours, second decocts plus 6 times of amount water, decocts 1 hour, with four layers of filtered through gauze, merges filtrate twice and add
It is 1 that heat, which is concentrated into medicine liquid volume and the ratio of crude drug,:1, be then cooled to 40 DEG C it is standby；
（2）In step（1）Concentrate in add 3%（Quality percent by volume）Enzyme preparation, described enzyme preparation is by matter
Amount is than being cellulase:Pectase:Protease=2:1:1 component composition, it is standby after then standing 12 hours；
（3）By step（2）Medicine liquid heating after standing is decocted 30 minutes, adds the purified water of 2.5 times of medicine liquid volumes, then add
Heat adds the dilute acetic acid solution containing 1% chitosan for accounting for medicine liquid volume 12% to 60 DEG C（The concentration of dilute acetic acid solution is 1%）, stirring
12 hours are stood afterwards, supernatant is taken, regulation solution ph is 7, is concentrated into the 1/3 of medicine liquid volume, then crosses 0.45 micron membrane filter,
Filling, sterilizing, thus obtaining the product.
Embodiment 3
It is used for the Chinese medicine composition for preventing and treating infectious coryza of chicken in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：22 parts of the Radix Astragali, 25 parts of safflower, 20 parts of Herba Andrographitis, 20 parts of the fruit of Chinese wolfberry, 20 parts of the fleece-flower root, 20 parts of radix scutellariae, 20 parts of barrenwort, the Qin
20 parts of skin, 20 parts of the fruit of glossy privet, 20 parts of rhizoma atractylodis, 15 parts of Radix Codonopsis, 15 parts of the tuber of dwarf lilyturf, 32 parts of folium isatidis, 25 parts of Chinese violet, Radix Angelicae Sinensis 18
Part, 10 parts of the coptis.
It is used for the preparation method for preventing and treating the Chinese medicine composition of infectious coryza of chicken in the present embodiment, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, decocted for the first time plus 9 times of amounts
Water, is decocted 2 hours, second decocts plus 7 times of amount water, decocts 1.5 hours, with four layers of filtered through gauze, merges filtrate twice and add
It is 1 that heat, which is concentrated into medicine liquid volume and the ratio of crude drug,:1, be then cooled to 50 DEG C it is standby；
（2）In step（1）Concentrate in add 2.5%（Quality percent by volume）Enzyme preparation, described enzyme preparation by
Mass ratio is cellulase:Pectase:Protease=2:1:1 component composition, it is standby after then standing 12 hours；
（3）By step（2）Medicine liquid heating after standing is decocted 25 minutes, adds the purified water of 1.5 times of medicine liquid volumes, then add
Heat adds the dilute acetic acid solution containing 1% chitosan for accounting for medicine liquid volume 10% to 70 DEG C（The concentration of dilute acetic acid solution is 1%）, stirring
12 hours are stood afterwards, supernatant is taken, regulation solution ph is 7.5, is concentrated into the 1/2 of medicine liquid volume, then crosses 0.45 micron of filter
Film, filling, sterilizing, thus obtaining the product.
Embodiment 4
It is used for the Chinese medicine composition for preventing and treating infectious coryza of chicken in the present embodiment, mainly by the bulk drug group of following parts by weight
Into：20 parts of the Radix Astragali, 22 parts of safflower, 17 parts of Herba Andrographitis, 15 parts of the fruit of Chinese wolfberry, 17 parts of the fleece-flower root, 15 parts of radix scutellariae, 18 parts of barrenwort, the Qin
10 parts of skin, 10 parts of the fruit of glossy privet, 10 parts of rhizoma atractylodis, 11 parts of Radix Codonopsis, 11 parts of the tuber of dwarf lilyturf, 30 parts of folium isatidis, 20 parts of Chinese violet, Radix Angelicae Sinensis 17
Part, 5 parts of the coptis, include the auxiliary material of following parts by weight：80 parts of sucrose plus beneficial 85 parts of powder.
It is used for the preparation method for preventing and treating the Chinese medicine composition of infectious coryza of chicken in the present embodiment, comprises the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, decocted for the first time plus 10 times of amounts
Water, is decocted 1.5 hours, second decocts plus 8 times of amount water, decocts 1 hour, with four layers of filtered through gauze, merges filtrate twice and add
Heat is concentrated into the thick paste that relative density at 70 DEG C is 1.20, is cooled to room temperature standby；
（2）In step（1）Thick paste in add concentration be 95% ethanol to alcohol content be 47.5%, stand 12 hours after take out
Filter, ethanol is recovered under reduced pressure, and to obtain decoction standby；
（3）Auxiliary material is accurately weighed according to parts by weight, in step（3）Decoction in be slowly added to mix sucrose and plus benefit
Powder, parboiling is stirred evenly, and particle is crossed into 32 mesh sieves after spray drying, is then dried in vacuo and is produced at 50 DEG C for 2 hours.
Through examining, granule prepared by parenteral solution and embodiment 4 prepared by above-described embodiment 1~3 meets quality standard.
Test example
Experimental animal：Henan breeding layer chicken, 180 age in days chickens have made a definite diagnosis generation chicken through clinical diagnosis and laboratory diagnosis
Infective rhinitis, 300 are randomly selected from ill chicken group, and the chicken individuals weight and the state of mind selected are approached, then random point
For 6 groups, every group 50.
Test group：Parenteral solution prepared by embodiment 1~3, every 0.5ml, one day 1 is subcutaneously injected in the neck of test group 1~3
It is secondary, it is used in conjunction 7 days；The feeding addition embodiment 4 of test group 4 prepares the chicken feed of granule, per 500g feeds addition granule 1g, often
Day 3~4 times, it is used in conjunction 7；The commercially available compound Tylosin Tartrate parenteral solution of control group hypodermic injection, every 0.5ml, 1 times a day
It is used in conjunction 7.Water for injection is subcutaneously injected in blank control group, and every 0.5ml 1 times a day, is used in conjunction 7.Result of the test refers to following table
1。
Curative effect judging standard：
Cure：The state of an illness, appetite, clinical symptoms recover normal completely after off-test；
Effectively：The state of an illness, appetite, clinical symptoms have taken a turn for the better after off-test；
It is invalid：The state of an illness, appetite, clinical symptoms are without taking a turn for the better and have a degradating trend after off-test.
Each treatment group of table 1 treats the result of the test of infectious coryza of chicken
Conclusion：Statistical analysis shows that the cure rate and total effective rate of test group are all remarkably higher than control group（P ＜ 0.01）,
Cure rate is up to more than 90%, and total effective rate is up to more than 94%.Wherein, it is preferred with the curative effect of test group 2.As can be seen from Table 1, this hair
The parenteral solution and granule of bright preparation can substantially control infectious coryza of chicken epidemic situation, relative to commercially available Western medicine, in security and
Advantage is had more in terms of efficient rate.
Claims (10)
1. a kind of Chinese medicine composition for being used to prevent and treat infectious coryza of chicken, it is characterised in that：By the bulk drug group of following parts by weight
Into：20~25 parts of the Radix Astragali, 20~25 parts of safflower, 15~20 parts of Herba Andrographitis, 15~20 parts of the fruit of Chinese wolfberry, 15~20 parts of the fleece-flower root, Huang
15~20 parts of a kind of reed mentioned in ancient books, 15~20 parts of barrenwort, 10~20 parts of the bark of ash, 10~20 parts of the fruit of glossy privet, 10~20 parts of rhizoma atractylodis, Radix Codonopsis 8~15
Part, 8~15 parts of the tuber of dwarf lilyturf, 30~35 parts of folium isatidis, 15~25 parts of Chinese violet, 15~18 parts of Radix Angelicae Sinensis, 5~10 parts of the coptis.
2. the Chinese medicine composition according to claim 1 for being used to prevent and treat infectious coryza of chicken, it is characterised in that：By following heavy
Measure the bulk drug composition of part：25 parts of the Radix Astragali, 20~22 parts of safflower, 15~18 parts of Herba Andrographitis, 18~22 parts of the fruit of Chinese wolfberry, the fleece-flower root 15
~20 parts, 18 parts of radix scutellariae, 15~20 parts of barrenwort, 12~15 parts of the bark of ash, 15 parts of the fruit of glossy privet, 12~18 parts of rhizoma atractylodis, Radix Codonopsis 8~15
Part, 8~15 parts of the tuber of dwarf lilyturf, 35 parts of folium isatidis, 15~20 parts of Chinese violet, 15~18 parts of Radix Angelicae Sinensis, 8 parts of the coptis.
3. the Chinese medicine composition according to claim 1 or 2 for being used to prevent and treat infectious coryza of chicken, it is characterised in that：Also wrap
Include the auxiliary material of following parts by weight：70~90 parts of sucrose plus beneficial 80~90 parts of powder.
4. a kind of preparation method as claimed in claim 1 or 2 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, it is special
Levy and be：Comprise the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, filtration merges filtrate twice and added
Heat concentration, be then cooled to 40~60 DEG C it is standby；
（2）In step（1）Concentrate in add 2~3% enzyme preparation, it is standby after standing；
（3）By step（2）Medicine liquid heating after standing is decocted 20~30 minutes, adds the purifying of 1.5~2.5 times of medicine liquid volumes
Water, is again heated to 60~80 DEG C, adds the acetum containing 1% chitosan for accounting for medicine liquid volume 8~12%, and stirring takes after standing
Clear liquid, regulation solution ph is 6.5~7.5, filtering, filling, sterilizing, thus obtaining the product after concentration.
5. the preparation method according to claim 4 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature exists
In：The step（1）Middle first time, which decocts, Jia 8~10 times of amount water, decocts 1~2 hour, second of decoction Jia 6~8 times of amount water,
Decoct 0.5~1.5 hour.
6. the preparation method according to claim 4 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature exists
In：The step（2）In enzyme preparation by mass ratio be cellulase:Pectase:Protease=2:1:1 component composition.
7. the preparation method according to claim 4 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature exists
In：The step（3）In be concentrated into the 1/3~1/2 of medicine liquid volume.
8. a kind of preparation method as claimed in claim 3 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature
It is：Comprise the following steps：
（1）Each taste bulk drug is accurately weighed according to parts by weight, heating is decocted twice after crushing, filtration merges filtrate twice and added
Heat is concentrated into the thick paste that relative density at 65~75 DEG C is 1.15~1.20, is cooled to room temperature standby；
（2）In step（1）Thick paste in add concentration be 80~95% ethanol to alcohol content be 45~50%, after standing filter,
It is standby that decompression filtrate recycling ethanol obtains decoction；
（3）In step（3）Decoction in add mixing sucrose and plus beneficial powder, parboiling is stirred evenly, by particle after spray drying
Sieving, then be dried in vacuo and produce.
9. the preparation method according to claim 8 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature exists
In：The step（1）Middle first time, which decocts, Jia 8~10 times of amount water, decocts 1~2 hour, second of decoction Jia 6~8 times of amount water,
Decoct 0.5~1.5 hour.
10. the preparation method according to claim 8 for being used to prevent and treat the Chinese medicine composition of infectious coryza of chicken, its feature exists
In：The step（4）In vacuum drying temperature be 45~60 DEG C, drying time be 1.5~2.5 hours.
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| CN105770135A (en) * | 2016-04-19 | 2016-07-20 | 烟台民望机电技术有限公司 | Chicken feed additive for preventing and treating infectious coryza of chickens and preparation method thereof |
| CN105878720A (en) * | 2016-06-22 | 2016-08-24 | 吴淑芬 | Compound traditional Chinese medicine for treating infectious rhinitis of chicken and preparation method thereof |
| CN107259093A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of duck infectious rhinitis and preparation method thereof |
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| 中兽药防治鸡多病因呼吸道病的思路;史万玉;《北方牧业》;20100220;12页"一、治本"部分 * |
| 野山鸡传染性鼻炎的诊治;潘明兴;《贵州畜牧兽医》;20110228;第35卷(第2期);38页右栏第2段,39页左栏第2段 * |
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