CN104161977A - Traditional Chinese medicinal composition used for preventing and treating infectious rhinitis of chicken, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition used for preventing and treating infectious rhinitis of chicken, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition used for preventing and treating infectious rhinitis of chicken, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines for animals. The traditional Chinese medicinal composition mainly comprises, by weight, 20-25 parts of Radix Astragali, 20-25 parts of safflower, 15-20 parts of Andrographis paniculata, 15-20 parts of wolfberry fruit, 15-20 parts of Polygonum multiflorum, 15-20 parts of Radix Scutellariae, 15-20 parts of epimeddium, 10-20 parts of Cortex Fraxini, 10-20 parts of Ligustri Lucidi Fructus, 10-20 parts of Atractylodes lancea, 8-15 parts of Radix Codonopsis, 8-15 parts of Liriope spicata, 30-35 parts of Folium Polygoni Tinctrorii, 15-25 parts of Herba Violae, 15-18 parts of Chinese angelica and 5-10 parts of Rhizoma Coptidis. The composition prepared by blending the above medicines according to a monarch, minister, assistant and guide principle has the efficacies of heat clearing, detoxifying, bacterium resisting, inflammation eliminating, body immunity improving and the like, and is mainly used for treating the infectious rhinitis of chicken.
Description
Technical field
The present invention is specifically related to a kind of for preventing and treating the Chinese medicine composition of infectious coryza of chicken, and the preparation method of this Chinese medicine composition, belongs to Chinese medicine technical field for animals.
Background technology
Infectious coryza of chicken is the acute respiratory disease by chicken that haemophilus paragallinarum causes.Cardinal symptom is nasal cavity and Dou Fayan, rhinorrhea, facial swelling and sneeze.Primary disease betides the chicken at various ages, and aged chicken infects comparatively serious., often can there is primary disease with nasal cavity artificial vaccination pathogenic bacteria in the chickling of 7d, the chickling of 3～4d is resistance slightly.The chicken susceptible in 4 week age to 3 year, but have individual diversity.Artificial challenge chicken in 4～8 week age has the typical symptom of 90% appearance.100% infection of 13 week age and larger chicken.In older chicken, incubation period is shorter, and the course of disease is long.Primary disease is distributed in the whole world, can cause the laying rate of the laying hen of infection generally to decline 10～40%, and the weightening finish of growth chicken is stagnated and superseded chicken quantity increases, and to aquaculture, brings serious economic loss.
At present, treatment infectious coryza of chicken generally adopts sulfa drugs, but these medicines not only have side effect, and easily produces drug resistance or cause drug residue, to human health, brings potential hazard.Have safely, have no side effect, the Chinese herbal and crude drugs preparations of noresidue is undoubtedly for control infectious coryza of chicken provides a new thinking, but Chinese herbal and crude drugs preparations in the market remains the shortcomings such as low in bioavailability, clinical effectiveness is not good.
Summary of the invention
The object of this invention is to provide a kind of for preventing and treating the Chinese medicine composition of infectious coryza of chicken.
Meanwhile, the present invention also provides a kind of for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken.
In order to realize above object, the technical solution adopted in the present invention is:
For preventing and treating a Chinese medicine composition for infectious coryza of chicken, mainly the crude drug by following weight portion forms: 20～25 parts of the Radixs Astragali, 20～25 parts, Flos Carthami, 15～20 parts of Herba Andrographis, 15～20 parts of Fructus Lycii, 15～20 parts of Radix Polygoni Multiflori, 15～20 parts of Radix Scutellariaes, 15～20 parts of Herba Epimedii, 10～20 parts of Cortex Fraxinis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Atractylodis, 8～15 parts of Radix Codonopsis, 8～15 parts of Radix Ophiopogonis, 30～35 parts of Folium Isatidiss, 15～25 parts of Herba Violaes, 15～18 parts of Radix Angelicae Sinensis, 5～10 parts of Rhizoma Coptidis.
Preferably, for preventing and treating a Chinese medicine composition for infectious coryza of chicken, mainly the crude drug by following weight portion forms: 25 parts of the Radixs Astragali, 20～22 parts, Flos Carthami, 15～18 parts of Herba Andrographis, 18～22 parts of Fructus Lycii, 15～20 parts of Radix Polygoni Multiflori, 18 parts of Radix Scutellariaes, 15～20 parts of Herba Epimedii, 12～15 parts of Cortex Fraxinis, 15 parts of Fructus Ligustri Lucidi, 12～18 parts of Rhizoma Atractylodis, 8～15 parts of Radix Codonopsis, 8～15 parts of Radix Ophiopogonis, 35 parts of Folium Isatidiss, 15～20 parts of Herba Violaes, 15～18 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Coptidis.
For preventing and treating a Chinese medicine composition for infectious coryza of chicken, also comprise the adjuvant of following weight portion: 70～90 parts of sucrose, add 80～90 parts, beneficial powder.
There is choosing, a kind of for preventing and treating the Chinese medicine composition of infectious coryza of chicken, also comprise the adjuvant of following weight portion: 80 parts of sucrose, add 85 parts, beneficial powder.
In the present invention, each crude drug effect is summarized as follows:
The Radix Astragali: be the root of pulse family Astragalus Radix Astagali and Radix Astragali; Contain saponin component as astragaloside, isoflavones components is as calycosin, and fatty acid is as Palmic acid and linoleic acid, and polysaccharide is as astragalus polysaccharides, heteropolysaccharide etc., and nearly 20 various trace elements; Radix Astragali nature and flavor are sweet, and temperature is returned lung, spleen channel; Energy benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Cure mainly the disease of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts and do not hold back for a long time; The modern pharmacology proof Radix Astragali can affect organism metabolism and have antioxidation, can also antithrombotic, antiviral, arthritis, anticancer, anti-inflammatory and antalgic, and protection cardio-cerebrovascular and promote hemopoietic function.
Flos Carthami: be the flower of Compositae Flos Carthami platymiscium Flos Carthami; Contain flavone compound as saffloside, front saffloside, safflower yellow A, B etc., Polyphenols is as chlorogenic acid, caffeic acid, catechol etc., also contain more than 80 and plant volatile ingredient as methyl cinnamate, Flos Caryophylli alkene, Flos Caryophylli alkene epoxide etc., and 16 seed amino acid as lysine, fatty acid, as Palmic acid, myristic acid, lauric acid, oleic acid etc., separately contains Flos Carthami polysaccharide and other multiple active components; Nature and flavor are pungent, warm, GUIXIN, Liver Channel; Energy promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Cure mainly blood stasis amenorrhea, dysmenorrhea, postpartum stagnation stomachache, obstruction of qi in the chest and cardialgia, lumps in the chest and abdomen, traumatic injury, arthralgia, apoplectic hemiplegia etc.; Modern pharmacology proof Flos Carthami has anticoagulation, antiinflammatory, antioxidation etc.
Herba Andrographis: be the herb of Acanthaceae Herba Andrographis platymiscium Herba Andrographis; Leaf contains Diterpenes as andrographolide etc., flavonoid is as oroxylin A, wogonin, also contain Polyphenols as caffeic acid, chlorogenic acid etc., root contains flavonoid as andrographin, andrographin glycosides A, B, C, D, E and F, also contains the various active compositions such as α-Sitosterol; Nature and flavor are bitter, contain GUIXIN, lung, large intestine, urinary bladder channel; Energy heat-clearing and toxic substances removing, pathogenic fire purging, dampness; Cure mainly anemopyretic cold, epidemic febrile disease heating, cough due to lung-heat, pertussis, lung abscess, laryngopharynx swelling and pain, toothache due to stomach-fire, acute bacillary dysentery, jaundice due to damp-heat, skin infection carbuncle etc.; That modern pharmacology proof Herba Andrographis has is antipyretic, antiinflammatory, anticancer, D-dimer, antithrombotic, hepatic cholagogic, blood pressure lowering, antioxidant protection Endothelial Cell Function etc.
Fructus Lycii: for Fructus Lycii is the fruit of Solanaceae Lycium plant lycium barbarum; Contain the various active compositions such as Allylamines, polysaccharide, cerebroside, ursolic acid, alkaloid, P-coumaric acid, daucosterol, carotene, atropine, hyoscyamine, Semen Maydis xanthin, physalin, kryptoxanthin, vitamin C; Nature and flavor are sweet, flat, return liver, kidney, lung meridian; Energy nourishing the liver, nourishing kidney, lung moistening; Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, cough due to consumptive disease etc.; Modern pharmacology proof Fructus Lycii has the effects such as slow down aging, anti-fatty liver, adjusting blood fat and blood glucose, promotion hemopoietic function, can also regulate body's immunity, effectively suppresses tumor growth and cell mutation etc.
Radix Polygoni Multiflori: be the tuber of Polygonaceae arsesmart Radix Polygoni Multiflori; Contain anthraquinone analog compound as various active compositions such as emodin, chrysophanol, chrysophanic acid anthrone, Radix Polygoni Multiflori the third element, piceids; Nature and flavor are bitter, sweet, puckery, and tepor, returns liver, the heart, kidney channel; Can nourishing the blood and yin, loosening bowel to relieve constipation, dispel the wind, detoxify; Cure mainly Light-headedness, cardiopalmus, insomnia, soreness of the waist and knees, early whitening of beard and hair, tinnitus, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula etc.; Modern pharmacology proof Radix Polygoni Multiflori has blood fat reducing, atherosclerosis, enhancing immunity, slow down aging, anti-genetic damage, antiinflammatory, analgesic activity etc.
Radix Scutellariae: be the root of Labiatae Scutellaria plant Radix Scutellariae; Contain flavone compound as baicalin, neobaicalein, baicalin, wogonoside etc., also contain the plurality of active ingredients such as cupreol, campesterol and stigmasterol; Nature and flavor are bitter, cold, return lung, the heart, liver, gallbladder, large intestine channel; Energy clearing away heat-fire, dampness removing toxic substances, hemostasis, antiabortive; Cure mainly lung-heat cough with asthma, calentura unconsciousness due to high fever, liver-fire headache, conjunctival congestion and swelling pain, jaundice due to damp-heat, dysentery, pyretic stranguria, tell nosebleed, excessive fetal movement due to heat in pregnancy, carbuncle furuncle etc.; Modern pharmacology proof Radix Scutellariae have antimicrobial, antiplatelet aggregation and anticoagulant, antioxidation, anticancer, reduce blood pressure and diuresis, effect for reducing blood fat etc.
Herba Epimedii: be stem, the leaf of Radix Berberidis Amurensis gram barrenwort Herba Epimedii, arrow leaf Herba Epimedii, Epimedium wushanense, Herba Epimedii, pubescence Herba Epimedii etc.; Its aerial parts contains flavonoid as epimedium flavone glycosides, epimedium flavone time glycosides I, and inorganic elements is as various active compositions such as potassium, calcium; Nature and flavor acrid, sweet, warm, return kidney, Liver Channel; Energy kidney invigorating and YANG supporting, strengthening the tendons and bones, expelling wind and removing dampness; Cure mainly the cough with asthma of suffering from a deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia etc.; Modern pharmacology proof Herba Epimedii has slow down aging, regulates immunologic function, prevents and treats osteoporosis, promotes union of fracture, antitumor action etc.
Cortex Fraxini: be the bark of Oleaceae Fraxinus plant great Ye Ash, sharp leaf Ash, Chinese ash and Fraxinus fallax Lingelsh．; Contain aesculin, aesculetin, also contain Coumarins as various active compositions such as aesculetin, fraxetin and alkaloids; Nature and flavor are bitter, puckery, cold, return liver, gallbladder, large intestine channel; Energy heat clearing and damp drying, liver heat removing and eyesight improving; Cure mainly damp-heat dysentery, conjunctival congestion and swelling pain, lung-heat asthma and cough etc.; That modern pharmacology proof Cortex Fraxini has is antibacterial, cough-suppressing phlegm-dispelling functions etc.
Fructus Ligustri Lucidi: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi; Contain triterpenes as oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid, phenolic glycoside class is as p-hydroxyphenylethanol, foreign syringin etc., iridoid glycosides is as nuzhenide, oleuropein, different nuzhenide etc., also contain flavonoid as raceme eriodictyol, Quercetin etc., and fatty acid is as Palmic acid, oleic acid etc., phospholipid is as LYSO-PHOSPHATIDYLCHOLINE LYSOPC, PHOSPHATIDYL ETHANOLAMINE etc., and volatile oil is as various active compositions such as thioacetones; Nature and flavor sweet, bitter, cold, returns liver, kidney channel, energy liver and kidney tonifying, clearind deficient heat, improving eyesight; Cure mainly Light-headedness, soreness of the waist and knees, tinnitus, early whitening of beard and hair, osteopyrexia and fever etc.; Modern pharmacology proof Fructus Ligustri Lucidi has antiinflammatory, blood sugar lowering, protects the liver, antimutagenesis etc.
Rhizoma Atractylodis: be the rhizome of Compositae [WTBX plant Atractylodes lancea (Thunb.) DC., Atractylis chinensis, atractylodes japonica; Contain volatile oil as β-Fructus Canarii albi alkene, chamigrene, Flos Caryophylli alkene, elemene etc., the various active compositions such as hemiterpene glucosides class, alkynes alkene class, also contain the inorganic elementss such as cobalt, chromium, copper, manganese, molybdenum; Nature and flavor are pungent, bitter, and temperature is returned spleen, stomach, Liver Channel; Can be drying damp and strengthening spleen, wind-damp dispelling, improving eyesight; Cure mainly that the spleen and stomach being stranded by dampness, asthenia drowsiness, feeling of stuffiness in chest abdominal distention, inappetence, vomiting are had loose bowels, phlegm retention, damp-edema, exterior syndrome folder are wet, a heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere are ached is weighing etc.; Modern pharmacology proof Rhizoma Atractylodis have anti-hypoxia, diuresis, arrhythmia, antibacterial, antivirus action etc.
Radix Codonopsis: be the root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens; Contain saccharide as fructose, inulin, polysaccharide and 4 kinds of heteropolysaccharide CP
1, CP
2, CP
3, CP
4glycoside is as ligustrin, n-hexyl-β-pyranglucoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component, as choline, loline etc., also contain the various active compositions such as syringic aldehyde, vanillic acid, pyromucic acid, atractyloide I, II; Radix Codonopsis nature and flavor are sweet, flat, return spleen, lung meridian; Energy strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung breath with cough, breathe hard spontaneous perspiration, all cards of deficiency of both QI and blood; Modern pharmacology proof Radix Codonopsis has enhancing body stress ability, enhancing human body immunity function, slow down aging, antiulcer, antitumor assosting effect etc.
Radix Ophiopogonis: be the tuber of Liliaceae Ophiopogon plant Radix Ophiopogonis or dwarf lilyturf; Contain saponins as ophiopogonin, high isoflavonoid class is as methyl flavanone Radix Ophiopogonis, and wet goods volatilizees; Sweet, the micro-hardship of Radix Ophiopogonis nature and flavor, is slightly cold, and returns lung, stomach, heart channel; Energy nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire; Cure mainly dryness of the lung dry cough, lung abscess, deficiency of YIN chronic cough, Tianjin wound is thirsty, quenches one's thirst, and vexed insomnia, has sore throat, dryness of the intestine constipation etc.; Modern pharmacology proof Radix Ophiopogonis exerts an influence to cardiovascular system, immunologic function, gastrointestinal motility function etc., also has antibacterial, arrhythmia, blood sugar lowering, removing free radical, slow down aging, resisting oxygen lack etc.
Folium Isatidis: be the leaf of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.; Contain the plurality of active ingredients such as indigo, Isatis indigotica Fort. glycosides, indirubin, rosasterol; Nature and flavor are bitter, cold; GUIXIN, stomach, liver, lung meridian; Energy heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly the high hot excessive thirst of epidemic febrile disease, coma, macule, spits blood, epistaxis, jaundice, dysentery, erysipelas, sore throat, aphtha, mumps etc.; Modern pharmacology proof Folium Isatidis has the effects such as resisting pathogenic microbes, antiendotoxin, antioxidation.
Herba Violae: be the herb of Violaceae Viola Chinese violet; Contain the various active compositions such as Palmic acid, P-hydroxybenzoic acid, trans p hydroxycinnamic acid; Nature and flavor bitter, acrid, cold, GUIXIN, Liver Channel; Energy heat-clearing and toxic substances removing, dampness removing heat from blood; Cure mainly furuncle carbuncle, erysipelas, acute mastitis, acute appendicitis, scrofula, damp-heat dysentery, conjunctival congestion and swelling pain etc.; Modern pharmacology proof Herba Violae has resisting pathogenic microbes effect etc.
Radix Angelicae Sinensis: be the root of Umbelliferae archangel Radix Angelicae Sinensis; Contain multiple volatile oil and organic acid, also contain more than 20 kind of inorganic elements and polysaccharide composition; Nature and flavor are sweet, pungent, bitter, and temperature is returned liver, the heart, spleen channel; Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturizes laxation; Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down etc.; Modern pharmacology proof Radix Angelicae Sinensis can affect blood and hemopoietic system, has blood fat reducing, arteriosclerosis, radioprotective, antitumor, anti-inflammatory and antalgic and injury-resistance etc.
Rhizoma Coptidis: be the rhizome of Ranunculaceae coptis plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis teeta; Contain alkaloids as plurality of active ingredients such as berberine, coptisine, epiberberine, obacunone; Nature and flavor are bitter, cold, GUIXIN, liver, stomach, large intestine channel; Energy clearing away heat-fire, dampness, removing toxic substances; Cure mainly the telling nosebleed, the damp and hot feeling of stuffiness in chest, have loose bowels of high heat that calentura heresy enters heart channel, irritated, delirium or the absurd shape of intenseness of heat forcing blood, dysentery, the vexed insomnia of hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue etc.; Modern pharmacology proof Rhizoma Coptidis has antimicrobial, disease-resistant protozoon, antiviral, arrhythmia, antiulcer, antitumor, antiinflammatory action etc.
A kind of for preventing and treating the Chinese medicine composition of infectious coryza of chicken, can adopt conventional method to be prepared into the Chinese herbal medicine dosage forms such as solution, powder, granule, soluble powder, pre-mixing agent, tablet, capsule, injection, wherein take injection and granule as good, and the present invention provides respectively the preparation method of a kind of injection and granule.
For preventing and treating a preparation method for the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverize post-heating and decoct twice, filter, merges twice filtrate heating and concentrate, be then cooled to 40～60 ℃ standby;
(2) in the concentrated solution of step (1), add 2～3% enzyme preparation, standing rear standby;
(3) medicine liquid heating after step (2) is standing decocts 20～30 minutes, the purified water that adds 1.5～2.5 times of medicine liquid volumes, be heated to again 60～80 ℃, add the acetum containing 1% chitosan that accounts for medicine liquid volume 8～12%, stir after standing and get supernatant, regulator solution pH value is 6.5～7.5, concentrates rear filtration, fill, sterilizing and get final product.
In described step (1), decoct and add 8～10 times of water gagings for the first time, decoct 1～2 hour, decoct and add 6～8 times of water gagings for the second time, decoct 0.5～1.5 hour.
In described step (1), be filtered into four layers of gauze.
The ratio that is concentrated into medicine liquid volume and crude drug in described step (1) is 1:1.
Enzyme preparation in described step (2) is cellulase by mass ratio: the component of pectase: protease=2:1:1 forms.
In described step (2), the standing time is 12 hours.
In described step (3), the standing time is 12 hours.
Described step is concentrated into 1/3～1/2 of medicine liquid volume in (3).
In described step (3), be filtered into 0.45 micron of filter membrane.
The usage and dosage of injection is: subcutaneous injection, every 0.5ml, 1 time on the one, is used in conjunction 7.
For preventing and treating a preparation method for the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverize post-heating and decoct twice, filter, merge twice filtrate and also heat and be concentrated into the thick paste that at 65～75 ℃, relative density is 1.15～1.20, be cooled to room temperature standby;
(2) in the thick paste of step (1), to add concentration be 80～95% ethanol to being 45～50% containing alcohol amount, standing rear filtration, and it is standby that decompression recycling ethanol obtains medicinal liquid;
(3) in the medicinal liquid of step (3), add the sucrose that mixes and add beneficial powder, parboiling, stirs evenly, after spraying is dry, granule is sieved, then vacuum drying and get final product.
In described step (1), decoct and add 8～10 times of water gagings for the first time, decoct 1～2 hour, decoct and add 6～8 times of water gagings for the second time, decoct 0.5～1.5 hour.
In described step (1), be filtered into four layers of gauze.
In described step (2), the standing time is 12 hours.
In described step (3), sieve as crossing 32 mesh sieves.
In described step (4), vacuum drying temperature is 45～60 ℃, and be 1.5～2.5 hours drying time.
The usage and dosage of granule is: every 500g feedstuff adds granule 1g, every day 3～4 times, is used in conjunction 7.
Beneficial effect of the present invention:
The present invention adopts the Radix Astragali, Flos Carthami, Herba Andrographis, Fructus Lycii, Radix Polygoni Multiflori, Radix Scutellariae, Herba Epimedii, Cortex Fraxini, Fructus Ligustri Lucidi, Rhizoma Atractylodis, Radix Codonopsis, Radix Ophiopogonis, Folium Isatidis, Herba Violae, Radix Angelicae Sinensis, Rhizoma Coptidis totally 16 taste pure natural Chinese herbal medicine, medicine source is extensive, have little without Drug resistance, toxic and side effects, be difficult for producing the features such as hazard residue in meat, its effective ingredient except participate in directly antibacterial, can also excite or specificity and the non-specific immunity of enhancing body, control infectious coryza of chicken is had to significant curative effect.In addition, in Chinese herbal medicine, contained protein, saccharide, fat, starch, trace element, vitamin etc., can directly provide chicken growth promoter required nutrient substance, can also reduce the irritability of domestic animal simultaneously.
In the present invention, all medicines are according to monarch principle composition of prescription, wherein, the Radix Astragali, Herba Andrographis, Radix Scutellariae, Folium Isatidis is monarch drug, there is heat-clearing and toxic substances removing, antimicrobial and anti-inflammation efficacy, Cortex Fraxini, Herba Violae, Radix Angelicae Sinensis, Rhizoma Coptidis is ministerial drug, there is heat clearing and damp drying, eliminating fire and detoxication effect, Fructus Lycii, Radix Polygoni Multiflori, Herba Epimedii, Fructus Ligustri Lucidi, Rhizoma Atractylodis, Radix Codonopsis, Radix Ophiopogonis is adjuvant drug, there is expelling wind and removing dampness, strong muscle key bone effect, Flos Carthami is for making medicine, there is promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing effect, all medicines share plays heat-clearing and toxic substances removing altogether, anti-inflammation, improve the effect of immunity of organisms, be mainly used in treating infectious coryza of chicken.
The present invention will be prepared into injection or granule for preventing and treating the Chinese medicine composition of infectious coryza of chicken, method is simple, easy to operate, and the injection character of preparation is stable, easy to use, bioavailability is high, can significantly improve immunity of organisms, enhancing body resistance against diseases, infectious coryza of chicken is had to good prophylactic-therapeutic effect, clinically extensive use.
The specific embodiment
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
In the present embodiment, for preventing and treating the Chinese medicine composition of infectious coryza of chicken, mainly the crude drug by following weight portion forms: 25 parts of the Radixs Astragali, 20 parts, Flos Carthami, 15 parts of Herba Andrographis, 18 parts of Fructus Lycii, 15 parts of Radix Polygoni Multiflori, 18 parts of Radix Scutellariaes, 15 parts of Herba Epimedii, 12 parts of Cortex Fraxinis, 15 parts of Fructus Ligustri Lucidi, 12 parts of Rhizoma Atractylodis, 8 parts of Radix Codonopsis, 8 parts of Radix Ophiopogonis, 35 parts of Folium Isatidiss, 15 parts of Herba Violaes, 15 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Coptidis.
In the present embodiment, for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverizing post-heating decocts twice, decoct and add 8 times of water gagings for the first time, decoct 1 hour, decoct and add 8 times of water gagings for the second time, decoct 0.5 hour, by four layers of filtered through gauze, merging the ratio that twice filtrate heating be concentrated into medicine liquid volume and crude drug is 1:1, be then cooled to 60 ℃ standby;
(2) in the concentrated solution of step (1), add 2%(quality percent by volume) enzyme preparation, described enzyme preparation is cellulase by mass ratio: the component of pectase: protease=2:1:1 forms, standby after then standing 12 hours;
(3) medicine liquid heating after step (2) is standing decocts 20 minutes, the purified water that adds 2 times of medicine liquid volumes, be heated to again 80 ℃, add the dilute acetic acid solution (concentration of dilute acetic acid solution is 1%) containing 1% chitosan that accounts for medicine liquid volume 8%, stir latter standing 12 hours, get supernatant, regulator solution pH value is 6.5, be concentrated into 1/3 of medicine liquid volume, then cross 0.45 micron of filter membrane, fill, sterilizing and get final product.
Embodiment 2
In the present embodiment, for preventing and treating the Chinese medicine composition of infectious coryza of chicken, mainly the crude drug by following weight portion forms: 25 parts of the Radixs Astragali, 22 parts, Flos Carthami, 18 parts of Herba Andrographis, 22 parts of Fructus Lycii, 20 parts of Radix Polygoni Multiflori, 18 parts of Radix Scutellariaes, 20 parts of Herba Epimedii, 15 parts of Cortex Fraxinis, 15 parts of Fructus Ligustri Lucidi, 18 parts of Rhizoma Atractylodis, 15 parts of Radix Codonopsis, 15 parts of Radix Ophiopogonis, 35 parts of Folium Isatidiss, 20 parts of Herba Violaes, 18 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Coptidis.
In the present embodiment, for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverizing post-heating decocts twice, decoct and add 10 times of water gagings for the first time, decoct 1.5 hours, decoct and add 6 times of water gagings for the second time, decoct 1 hour, by four layers of filtered through gauze, merging the ratio that twice filtrate heating be concentrated into medicine liquid volume and crude drug is 1:1, be then cooled to 40 ℃ standby;
(2) in the concentrated solution of step (1), add 3%(quality percent by volume) enzyme preparation, described enzyme preparation is cellulase by mass ratio: the component of pectase: protease=2:1:1 forms, standby after then standing 12 hours;
(3) medicine liquid heating after step (2) is standing decocts 30 minutes, the purified water that adds 2.5 times of medicine liquid volumes, be heated to again 60 ℃, add the dilute acetic acid solution (concentration of dilute acetic acid solution is 1%) containing 1% chitosan that accounts for medicine liquid volume 12%, stir latter standing 12 hours, get supernatant, regulator solution pH value is 7, be concentrated into 1/3 of medicine liquid volume, then cross 0.45 micron of filter membrane, fill, sterilizing and get final product.
Embodiment 3
In the present embodiment, for preventing and treating the Chinese medicine composition of infectious coryza of chicken, mainly the crude drug by following weight portion forms: 22 parts of the Radixs Astragali, 25 parts, Flos Carthami, 20 parts of Herba Andrographis, 20 parts of Fructus Lycii, 20 parts of Radix Polygoni Multiflori, 20 parts of Radix Scutellariaes, 20 parts of Herba Epimedii, 20 parts of Cortex Fraxinis, 20 parts of Fructus Ligustri Lucidi, 20 parts of Rhizoma Atractylodis, 15 parts of Radix Codonopsis, 15 parts of Radix Ophiopogonis, 32 parts of Folium Isatidiss, 25 parts of Herba Violaes, 18 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Coptidis.
In the present embodiment, for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverizing post-heating decocts twice, decoct and add 9 times of water gagings for the first time, decoct 2 hours, decoct and add 7 times of water gagings for the second time, decoct 1.5 hours, by four layers of filtered through gauze, merging the ratio that twice filtrate heating be concentrated into medicine liquid volume and crude drug is 1:1, be then cooled to 50 ℃ standby;
(2) in the concentrated solution of step (1), add 2.5%(quality percent by volume) enzyme preparation, described enzyme preparation is cellulase by mass ratio: the component of pectase: protease=2:1:1 forms, standby after then standing 12 hours;
(3) medicine liquid heating after step (2) is standing decocts 25 minutes, the purified water that adds 1.5 times of medicine liquid volumes, be heated to again 70 ℃, add the dilute acetic acid solution (concentration of dilute acetic acid solution is 1%) containing 1% chitosan that accounts for medicine liquid volume 10%, stir latter standing 12 hours, get supernatant, regulator solution pH value is 7.5, be concentrated into 1/2 of medicine liquid volume, then cross 0.45 micron of filter membrane, fill, sterilizing and get final product.
Embodiment 4
In the present embodiment for preventing and treating the Chinese medicine composition of infectious coryza of chicken, mainly the crude drug by following weight portion forms: 20 parts of the Radixs Astragali, 22 parts, Flos Carthami, 17 parts of Herba Andrographis, 15 parts of Fructus Lycii, 17 parts of Radix Polygoni Multiflori, 15 parts of Radix Scutellariaes, 18 parts of Herba Epimedii, 10 parts of Cortex Fraxinis, 10 parts of Fructus Ligustri Lucidi, 10 parts of Rhizoma Atractylodis, 11 parts of Radix Codonopsis, 11 parts of Radix Ophiopogonis, 30 parts of Folium Isatidiss, 20 parts of Herba Violaes, 17 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Coptidis, also comprise the adjuvant of following weight portion: 80 parts of sucrose, add 85 parts, beneficial powder.
In the present embodiment, for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverizing post-heating decocts twice, decoct and add 10 times of water gagings for the first time, decoct 1.5 hours, decoct and add 8 times of water gagings for the second time, decoct 1 hour, by four layers of filtered through gauze, merge twice filtrate and also heat and be concentrated into the thick paste that at 70 ℃, relative density is 1.20, be cooled to room temperature standby;
(2) in the thick paste of step (1), to add concentration be 95% ethanol to being 47.5% containing alcohol amount, sucking filtration after standing 12 hours, and it is standby that decompression recycling ethanol obtains medicinal liquid;
(3) according to weight portion, accurately take adjuvant, slowly add the sucrose that mixes and add beneficial powder in the medicinal liquid of step (3), parboiling, stirs evenly, and after spraying is dry, granule is crossed to 32 mesh sieves, then vacuum drying 2 hours and get final product at 50 ℃.
Through check, the granule of the injection of above-described embodiment 1～3 preparation and embodiment 4 preparations all meets quality standard.
Test example
Experimental animal: breeding layer chicken field, Henan, 180 age in days chickens have been made a definite diagnosis generation infectious coryza of chicken through clinical diagnosis and laboratory diagnosis, from ill chicken group, choose at random 300, and the chicken individuals of selecting is heavy and the mental status is approaching, be divided at random again 6 groups, 50 every group.
Test group: the injection of test group 1～3 cervical region subcutaneous injection embodiment 1～3 preparation, every 0.5ml, 1 time on the one, is used in conjunction 7 days; Test group 4 is fed and is added the chicken feedstuff that embodiment 4 prepares granule, and every 500g feedstuff adds granule 1g, every day 3～4 times, is used in conjunction 7; The commercially available compound recipe tylosin tartrate of matched group subcutaneous injection injection, every 0.5ml, is used in conjunction 71 time on the one.Blank group subcutaneous injection water for injection, every 0.5ml, 1 time on the one, is used in conjunction 7.Result of the test refers to following table 1.
Curative effect judging standard:
Cure: after off-test, the state of an illness, appetite, clinical symptoms recover normal completely;
Effective: after off-test, the state of an illness, appetite, clinical symptoms take a turn for the better to some extent;
Invalid: after off-test, the state of an illness, appetite, clinical symptoms are without taking a turn for the better and having degradating trend.
The result of the test of each processed group treatment infectious coryza of chicken of table 1
Conclusion: statistical analysis shows, the cure rate of test group and total effective rate are all significantly higher than matched group (P < 0.01), and cure rate reaches more than 90%, and total effective rate reaches more than 94%.Wherein, take the curative effect of test group 2 as good.As can be seen from Table 1, injection prepared by the present invention and granule can obviously be controlled infectious coryza of chicken epidemic situation, with respect to commercially available Western medicine, aspect safety and effective percentage rate, are having more advantage.
Claims (10)
1. for preventing and treating a Chinese medicine composition for infectious coryza of chicken, it is characterized in that: mainly the crude drug by following weight portion forms: 20～25 parts of the Radixs Astragali, 20～25 parts, Flos Carthami, 15～20 parts of Herba Andrographis, 15～20 parts of Fructus Lycii, 15～20 parts of Radix Polygoni Multiflori, 15～20 parts of Radix Scutellariaes, 15～20 parts of Herba Epimedii, 10～20 parts of Cortex Fraxinis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Atractylodis, 8～15 parts of Radix Codonopsis, 8～15 parts of Radix Ophiopogonis, 30～35 parts of Folium Isatidiss, 15～25 parts of Herba Violaes, 15～18 parts of Radix Angelicae Sinensis, 5～10 parts of Rhizoma Coptidis.
2. according to claim 1 for preventing and treating the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: mainly the crude drug by following weight portion forms: 25 parts of the Radixs Astragali, 20～22 parts, Flos Carthami, 15～18 parts of Herba Andrographis, 18～22 parts of Fructus Lycii, 15～20 parts of Radix Polygoni Multiflori, 18 parts of Radix Scutellariaes, 15～20 parts of Herba Epimedii, 12～15 parts of Cortex Fraxinis, 15 parts of Fructus Ligustri Lucidi, 12～18 parts of Rhizoma Atractylodis, 8～15 parts of Radix Codonopsis, 8～15 parts of Radix Ophiopogonis, 35 parts of Folium Isatidiss, 15～20 parts of Herba Violaes, 15～18 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Coptidis.
3. according to claim 1 and 2 for preventing and treating the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: the adjuvant that also comprises following weight portion: 70～90 parts of sucrose, add 80～90 parts, beneficial powder.
4. as claimed in claim 1 or 2 for preventing and treating a preparation method for the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverize post-heating and decoct twice, filter, merges twice filtrate heating and concentrate, be then cooled to 40～60 ℃ standby;
(2) in the concentrated solution of step (1), add 2～3% enzyme preparation, standing rear standby;
(3) medicine liquid heating after step (2) is standing decocts 20～30 minutes, the purified water that adds 1.5～2.5 times of medicine liquid volumes, be heated to again 60～80 ℃, add the acetum containing 1% chitosan that accounts for medicine liquid volume 8～12%, stir after standing and get supernatant, regulator solution pH value is 6.5～7.5, concentrates rear filtration, fill, sterilizing and get final product.
5. according to claim 4 for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: in described step (1), decoct and add 8～10 times of water gagings for the first time, decoct 1～2 hour, decoct and add 6～8 times of water gagings for the second time, decoct 0.5～1.5 hour.
6. according to claim 4 for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: the enzyme preparation in described step (2) is cellulase by mass ratio: the component of pectase: protease=2:1:1 forms.
7. according to claim 4 for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: described step is concentrated into 1/3～1/2 of medicine liquid volume in (3).
8. as claimed in claim 3 for preventing and treating a preparation method for the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: comprise the following steps:
(1) according to weight portion, accurately take each taste crude drug, pulverize post-heating and decoct twice, filter, merge twice filtrate and also heat and be concentrated into the thick paste that at 65～75 ℃, relative density is 1.15～1.20, be cooled to room temperature standby;
(2) in the thick paste of step (1), to add concentration be 80～95% ethanol to being 45～50% containing alcohol amount, standing rear filtration, and it is standby that decompression filtrate recycling ethanol obtains medicinal liquid;
(3) in the medicinal liquid of step (3), add the sucrose that mixes and add beneficial powder, parboiling, stirs evenly, after spraying is dry, granule is sieved, then vacuum drying and get final product.
9. according to claim 8 for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: in described step (1), decoct and add 8～10 times of water gagings for the first time, decoct 1～2 hour, decoct and add 6～8 times of water gagings for the second time, decoct 0.5～1.5 hour.
10. according to claim 8 for preventing and treating the preparation method of the Chinese medicine composition of infectious coryza of chicken, it is characterized in that: in described step (4), vacuum drying temperature is 45～60 ℃, be 1.5～2.5 hours drying time.
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| CN104922197A (en) * | 2015-07-07 | 2015-09-23 | 杨南松 | Combination for improving chicken resistance |
| CN105770135A (en) * | 2016-04-19 | 2016-07-20 | 烟台民望机电技术有限公司 | Chicken feed additive for preventing and treating infectious coryza of chickens and preparation method thereof |
| CN105878720A (en) * | 2016-06-22 | 2016-08-24 | 吴淑芬 | Compound traditional Chinese medicine for treating infectious rhinitis of chicken and preparation method thereof |
| CN107259093A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of duck infectious rhinitis and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104922197A (en) * | 2015-07-07 | 2015-09-23 | 杨南松 | Combination for improving chicken resistance |
| CN105770135A (en) * | 2016-04-19 | 2016-07-20 | 烟台民望机电技术有限公司 | Chicken feed additive for preventing and treating infectious coryza of chickens and preparation method thereof |
| CN105878720A (en) * | 2016-06-22 | 2016-08-24 | 吴淑芬 | Compound traditional Chinese medicine for treating infectious rhinitis of chicken and preparation method thereof |
| CN107259093A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of duck infectious rhinitis and preparation method thereof |
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Effective date of registration: 20211221 Address after: 463000 Zhumadian Industrial Park, Henan Province Patentee after: HENAN HOUYI PHARMACY CO.,LTD. Address before: 451162 Henan Zhengzhou Zhengzhou airport comprehensive economic experimentation area, Xingang Avenue East Patentee before: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. |