CN102755519A - Kudzuvine root-kudzuvine flower anti-canker sore particle and preparation method thereof - Google Patents
Kudzuvine root-kudzuvine flower anti-canker sore particle and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kudzuvine root-kudzuvine flower anti-canker sore particle and a preparation method thereof. The kudzuvine root-kudzuvine flower anti-canker sore particle mainly comprises the following raw materials in parts by weight: 700-900 parts of kudzuvine root, 100-200 parts of kudzuvine flower, 10-20 parts of pseudo-ginseng root, 100-200 parts of dwarf lilyturf root, 100-200 parts of dahurian angelica root, 50-100 parts of coptis root, 100-150 parts of baikal skullcap root, 200-300 parts of amur corktree bark and 150-200 parts of liquorice root. The method comprises the following steps of: extracting a kudzuvine root extracting solution or performing spray drying on the concentrating solution to obtain kudzuvine root dry powder; extracting a kudzuvine flower extract or drying and smashing the extract to obtain kudzuvine flower extract dry powder; extracting volatile oil from six types of medicinal materials including dwarf lilyturf root, dahurian angelica root, coptis root, baikal skullcap root, amur corktree bark and liquorice root, and concentrating a filtrate under reduced pressure to obtain a mixture extract or drying and smashing the extract to obtain mixture extract dry powder; and mixing the extract with pseudo-ginseng root powder and an appropriate quantity of auxiliary materials. The particle disclosed by the invention can be used for converging canker sore and promoting mucosal ulcer surface healing.
Description
Technical field
The invention belongs to medicine and medicament preparation technical field, be specifically related to anti-oral ulcer granule of a kind of Radix Puerariae Flos puerariae lobatae and preparation method thereof.
Background technology
Oral ulcer is a kind of common disease of cari oris mucosa, and the sickness rate in the crowd is about 20%, and has the characteristics of periodical attack, and it shows as oral mucosa has patch ulcer, redness, and the surface coverage tunica albuginea has spontaneous pain, and assassination swashs and can aggravate the pain.At present, mainly be to take symptomatic treatment to this disease clinically, spray commonly used or powder paster, pad pasting etc. impose on the affected part, to diminish inflammation, ease the pain, to shorten the course of disease.The traditional Chinese medical science thinks that oral ulcer belongs to " aphtha ", " erosion of the oral mucosa ", " getting angry in the oral cavity " category.As a kind of traditional medicine food dual purpose plant, Radix Puerariae, Flos puerariae lobatae medicinal, edible with a long history.Put down in writing according to medical ancient books and records such as Shennong's Herbal, Compendium of Material Medica: Radix Puerariae sweet in the mouth, suffering, flat, nontoxic; Have that the toxin expelling of relieving inflammation or internal heat, relieving restlessness quench the thirst, blood sugar lowering, cholesterol reducing, nourishing the human Body, effect such as relieve the effect of alcohol; Acute toothache, laryngopharynx swelling and pain, heat syndrome cough, hyperpyrexia etc. there are obvious curative effects, prophylaxis of hypertension, hyperlipidemia, coronary heart disease are had special efficacy; Flos puerariae lobatae has effects such as heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, promoting digestion, protecting liver, can be used for anti-treating dental ulcer, laryngopharynx swelling and pain, toothache caused by fire of deficiency type etc.Modern study shows: Radix Puerariae contains starch, polysaccharide, puerarin, puerarin xyloside, daidzein, daidzin, cupreol and protein, crude fibre, vitamin, mineral etc.; Flos puerariae lobatae contains materials such as volatile oil, sterol, Saponin, polyphenol, flavone.In view of the contained active component of Radix Puerariae, Flos puerariae lobatae and special medicinal, health care thereof are worth; The development and use of Radix Puerariae, Flos puerariae lobatae receive people's attention always; And developed some medicines and functional food, like Radix Puerariae Flos puerariae lobatae beverage, drunkenness dispelling kudzuvine flower sheet, Kkudzu incense sugar, Radix Puerariae starch, puerarin etc.
Summary of the invention
First order of the present invention provides the anti-oral ulcer granule of a kind of Radix Puerariae Flos puerariae lobatae.
The anti-oral ulcer granule of Radix Puerariae Flos puerariae lobatae of the present invention mainly consists of: the Radix Puerariae of 700-900 weight portion, the Flos puerariae lobatae of 100-200 weight portion; The Radix Notoginseng of 10-20 weight portion, the Radix Ophiopogonis of 100-200 weight portion, the Radix Angelicae Dahuricae of 100-200 weight portion; The Rhizoma Coptidis of 50-100 weight portion; The Radix Scutellariae of 100-150 weight portion, the Cortex Phellodendri of 200-300 weight portion, the Radix Glycyrrhizae of 150-200 weight portion.
Said Radix Puerariae is the tuber of legume pueraria lobata or Pachyrhizua angulatus; Flos puerariae lobatae is the alabastrum of legume pueraria lobata or Pachyrhizua angulatus; Be the Liliaceae herbaceos perennial dry tuber of Radix Ophiopogonis Radix Ophiopogonis; Radix Notoginseng is the perennial panax species Radix Notoginseng of an Araliaceae rhizome; The Radix Angelicae Dahuricae is the dry root of the samphire Radix Angelicae Dahuricae; Rhizoma Coptidis is the dry rhizome of cohosh Rhizoma Coptidis; Radix Scutellariae is the dry root of Labiatae Scutellaria Radix Scutellariae; Cortex Phellodendri is the dry bark of Rutaceae perennial woody plant Cortex Phellodendri; Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume.
Second purpose of the present invention provides the particulate method for preparing of the anti-oral ulcer of above-mentioned Radix Puerariae Flos puerariae lobatae, and this method comprises the step of following order:
(1) prepares following proportion raw material: the Radix Puerariae of 700-900 weight portion, the Flos puerariae lobatae of 100-200 weight portion, the Radix Notoginseng of 10-20 weight portion; The Radix Ophiopogonis of 100-200 weight portion; The Radix Angelicae Dahuricae of 100-200 weight portion, the Rhizoma Coptidis of 50-100 weight portion, the Radix Scutellariae of 100-150 weight portion; The Cortex Phellodendri of 200-300 weight portion, the Radix Glycyrrhizae of 150-200 weight portion;
(2) with after the raw material Radix Puerariae chopping, be incorporated as water logging bubble 1-2 hour post-heating to 100 that Radix Puerariae volume 5-10 doubly measures ℃, continue heating, reflux, extract, 0.5-1 hour, filter, collect filtrating; The Pueraria lobota slag is incorporated as the water that Pueraria lobota slag volume 5-10 doubly measures again, continues heating extraction 1-1.5 hour, filters, and collects filtrating; Merge above filtrating, relative density is 1.10-1.20 when being evaporated to 50 ℃, gets the Radix Puerariae concentrated solution; Concentrated solution is spray-dried, gets Radix Puerariae dry powder;
(3) the raw material Flos puerariae lobatae is pulverized after, be incorporated as the water that Flos puerariae lobatae volume 5-10 doubly measures or the mixed solution of second alcohol and water and soaked 0 ~ 1 hour, wherein, concentration of alcohol is 50%-70%, heating and refluxing extraction 0.5-1 hour then, filter, collect filtrating; Be incorporated as the water that filtering residue volume 5-10 doubly measures in the filtering residue, continued heating extraction 1-1.5 hour, filter, collect filtrating; Merge above filtrating, relative density is the extractum of 1.30-1.35 when being evaporated to 50 ℃, gets Flos puerariae lobatae extractum; Extractum gets the Flos puerariae lobatae extract dry powder through crushed after being dried;
(4) Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; Being incorporated as for the first time the decocting that raw material cumulative volume 8-10 doubly measures boiled 1-2 hour; Filter, be incorporated as the decocting that raw material cumulative volume 8-10 doubly measures for the second time and boiled 1-2 hour, filter; Merge filtering filtrating twice, relative density is the mixture extractum such as Radix Ophiopogonis of 1.25-1.30 when being evaporated to 50 ℃; Extractum gets mixture extract dry powder such as Radix Ophiopogonis through crushed after being dried;
(5) the raw material Radix Notoginseng powder is broken into fine powder, crosses the 80-100 mesh sieve;
(6) with an amount of adjuvant, with from step (2), extract the Radix Puerariae dry powder obtain, step (3) in extract mixture extract dry powder such as extracting Radix Ophiopogonis of obtaining in the Flos puerariae lobatae extract dry powder that obtains, the step (4) and the Radix Notoginseng fine powder mixes; Perhaps, the Radix Puerariae concentrated solution that step (2) is obtained, the Flos puerariae lobatae extractum that step (3) obtains, that mixture extractum Radix Ophiopogonis that step (4) obtains mixes the back is spray-dried, obtain extract mixtures dry powder after, mix with Radix Notoginseng fine powder and an amount of adjuvant again; Perhaps; The Radix Puerariae concentrated solution that step (2) is obtained mixes back spray-dried with the Flos puerariae lobatae extractum that step (3) obtains; Radix Puerariae Flos puerariae lobatae extract mixture dry powder, obtain with step (4) again Radix Ophiopogonis mixture extractum and Radix Notoginseng fine powder and an amount of adjuvant mix; Wherein, the quality summation of medicinal raw material is 1:3.0 ~ 1:3.5 with the ratio of adjuvant quality summation; In mixed process, measure few composition and adopt the equivalent method of progressively increasing to add; After the mix homogeneously, spray into concentration and be 50% ethanol, process soft material, soft material is granulated through extruding and is obtained wet granular, and the granulation sieve number is the 10-20 order; Must do granule behind the gained wet grain drying, then step (4) gained volatile oil evenly sprayed in the dried granule, promptly get the anti-oral ulcer granule of Radix Puerariae Flos puerariae lobatae after airtight a period of time.
Said adjuvant is one or more in cane sugar powder, dextrin, Celluloasun Microcrystallisatum, steviosin, sodium bicarbonate, the citric acid.
The pharmacological property of other raw material is following among the present invention:
Radix Notoginseng has the effect of hemostasis, blood circulation promoting and blood stasis dispelling and anti-inflammatory analgetic; Radix Ophiopogonis cold nature, sweet in the mouth, little hardship can YIN nourishing and the production of body fluid promoting, lung moistening relieves inflammation or internal heat; The Radix Angelicae Dahuricae has diffusing wind dehumidifying, understand things pain-stopping, the dense effect of detumescence row, has enhance immunity, promotes growth and antitumor action; The Rhizoma Coptidis sweet in the mouth is cold in nature, ability heat clearing and damp drying, eliminating fire and detoxication; The Radix Scutellariae bitter in the mouth is cold in nature, has the effect of heat clearing and damp drying, eliminating fire and detoxication, is widely used in diseases such as skin infection furuncle and phyma clinically; The Cortex Phellodendri nature and flavor are bitter, cold, and heat clearing and damp drying, eliminating fire and detoxication, treatment skin ulcer, antimicrobial effect are arranged; Radix Glycyrrhizae has than the strong solution toxic action, and corticoid effects such as antiinflammatory, antiallergic are arranged, and can activate the autoimmune defence system, improves the resistance of body to harmful substance, and Radix Glycyrrhizae is as messenger drug, but coordinating the actions of various ingredients in a prescription, and priming is up.
Granule of the present invention is a primary raw material with the extract active component of Radix Puerariae, Flos puerariae lobatae; And be aided with Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae extract and Radix Notoginseng, have that heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, dispelling wind pathogenic fire purging, blood circulation promoting and blood stasis dispelling, antiinflammatory are analgesic, the effect of reducing swelling and alleviating pain.Granule of the present invention is used to treat oral ulcer, oral ulcer is played convergence, the face healing of promotion mucosal ulcer, dissipating blood stasis analgesic therapy, ends the effect of infections granulation promoting, and mucocutaneous blood vessel is had the certain shrink effect.Can take after only need dashing when granule of the present invention uses with eliminating cold for resuscitation water, easy to use.Observe through clinical use, this anti-oral ulcer granule has curative effect preferably to oral ulcer.Below be that the curative effect record is used in clinical trial:
One, clinical data:
1, physical data: select oral ulcer patient's 200 examples through clinical definite, male patient's 120 examples wherein, female patient 80 examples (except women breast-feeding their children and the anemia of pregnant woman) are divided into 2 groups at random by the time of making a definite diagnosis.125 examples are organized in treatment, male's 80 examples, women's 45 examples; Matched group 75 examples, male's 40 examples wherein, women's 35 examples.
2, clinical diagnosis standard: according to " recurrent aphtha evaluation tentative standard " that oral mucosal disease Professional Committee of Chinese Medical Association announces, the experimenter who meets following standard can participate in voluntarily:
(1) age 18-50 year;
(2) the ulcer time of origin was treated in 48 hours as yet;
(3) except that the oral ulcer of having made a definite diagnosis, other are in a good state of health.
3, Therapeutic Method:
(1) treatment group: the treatment group is taken Radix Puerariae of the present invention, the anti-oral ulcer granule of Flos puerariae lobatae, each 5 grams, every day three times, warm boiled water.Continuous 10 days is a course of treatment, two courses of treatment of every patient's continuous use.
(2) matched group: oral vitamin B
2Sheet 10 mg, three every days; Catergen 00 mg, three every days; Compound borax liquid is gargled, three every days.2 mL of intramuscular injection transfer factor (3 mg/2 mL/ prop up) simultaneously, 3 times weekly, 10 times is 1 course of treatment.
(3) points for attention: during the treatment, all inactive other medicines of treatment group and matched group are noted oral hygiene, the food that avoids pungent food, and avoid overtired.
Two, therapeutic evaluation and therapeutic effect:
1, treatment evaluation criterion: criterion of therapeutical effect with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine promulgation and Chinese stomatology in 2000 can the formulation of oral mucosal disease Professional Committee recurrent oral ulceration therapeutic evaluation tentative standard observe the curative effect.Cure: suffer from the complete obiteration of oral disease symptom; Effectively: suffer from the oral disease sx; Invalid: symptom does not ditto have improvement.
2, therapeutic outcome:
After 1 course of therapy, treatment group and matched group efficacy result see the following form 1:
Visible from table 1, treatment group cure rate is 96.0%, and apparently higher than matched group (82.7%), treatment is organized average onset time obviously faster than matched group, and treatment group average cure time is significantly shorter than matched group, and this explanation treatment group therapeutic effect obviously is superior to matched group.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described in further detail.
Embodiment 1: Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae, prescription is: Radix Puerariae 900 g, Flos puerariae lobatae 100 g, Radix Notoginseng 10 g, Radix Ophiopogonis 100 g, the Radix Angelicae Dahuricae 150 g, Rhizoma Coptidis 60 g, Radix Scutellariae 120 g, Cortex Phellodendri 200 g, Radix Glycyrrhizae 200g.
Method for preparing:
The first step: with after the Radix Puerariae chopping, add 5 times of water gagings of Radix Puerariae and soak 1 hour post-heating to 100 ℃, continue heating, reflux, extract, 0.5 hour is filtered, and collects filtrating; The Pueraria lobota slag adds 8 times of water gagings of raw material, and heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Radix Puerariae concentrated solution that relative density is 1.13 (50 ℃), and concentrated solution is spray-dried, get powder of Radix Puerariae;
Flos puerariae lobatae is pulverized the back add 6 times of water gagings and soaked 1 hour post-heating reflux, extract, 1 hour, filter, collect filtrating; Add 8 times of water gagings of raw material in the Flos puerariae lobatae slag, heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Flos puerariae lobatae extractum that relative density is 1.30 (50 ℃); Extractum gets the Flos puerariae lobatae extract powder through crushed after being dried;
Second step: Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, and it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; The decocting that adds for the first time 10 times of amounts boiled 1.5 hours; The decocting that adds for the second time 8 times of amounts boiled 2 hours; Filter, merging filtrate, concentrating under reduced pressure get the mixture extractum such as Radix Ophiopogonis that relative density is 1.25 (50 ℃); Extractum gets mixture extract dry powder such as Radix Ophiopogonis through crushed after being dried;
The 3rd step: Radix Notoginseng powder is broken into fine powder, crosses 80 mesh sieves;
The 4th step: get cane sugar powder 450 grams, dextrin 300 grams, powder of Radix Puerariae 180 grams, mixing; Other gets mixture extract dry powder 50 grams Radix Ophiopogonis, Flos puerariae lobatae extract dry powder 10 grams, Radix Notoginseng powder 10 grams, mixing; These two kinds of mixed-powders are adopted equivalent method mixing that progressively increases, and spraying into concentration is that 50% ethanol is an amount of, processes soft material, soft material through extruding granulate wet granular, the granulation sieve number is 10 orders.Must do granule behind the gained wet grain drying, then volatile oil evenly is sprayed in the dried granule, promptly get Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae after airtight a period of time.
Instructions of taking: each 5 grams, every day three times, warm boiled water.Food avoids pungent food.
Embodiment 2: Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae, prescription is: Radix Puerariae 750 g, Flos puerariae lobatae 200 g, Radix Notoginseng 15 g, Radix Ophiopogonis 150 g, the Radix Angelicae Dahuricae 150 g, Rhizoma Coptidis 50 g, Radix Scutellariae 100 g, Cortex Phellodendri 200 g, Radix Glycyrrhizae 180g.
Method for preparing:
The first step: with after the Radix Puerariae chopping, add 5 times of water gagings of Radix Puerariae and soak 1 hour post-heating to 100 ℃, continue heating, reflux, extract, 0.5 hour is filtered, and collects filtrating; The Pueraria lobota slag adds 8 times of water gagings of raw material, and heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Radix Puerariae concentrated solution that relative density is 1.20 (50 ℃);
Flos puerariae lobatae is pulverized the back add 6 times of water gagings and soaked 1 hour post-heating reflux, extract, 1 hour, filter, collect filtrating; Add 8 times of water gagings of raw material in the Flos puerariae lobatae slag, heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Flos puerariae lobatae extractum that relative density is 1.35 (50 ℃);
Second step: Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, and it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; The decocting that adds for the first time 10 times of amounts boiled 1 hour; The decocting that adds for the second time 8 times of amounts boiled 1 hour; Filter, merging filtrate, concentrating under reduced pressure get mixture extractum Radix Ophiopogonis that relative density is 1.26 (50 ℃);
The 3rd step:, get extract mixtures dry powder with spray-dried after Radix Puerariae concentrated solution, Flos puerariae lobatae extractum, mixture extractum mixing Radix Ophiopogonis;
The 4th step: Radix Notoginseng powder is broken into fine powder, crosses 80 mesh sieves;
The 5th step: get cane sugar powder 450 grams, dextrin 320 grams, extract mixtures dry powder 215 grams, mixing; Other gets Radix Notoginseng powder 15 gram, adopts the equivalent method of progressively increasing to add, and spraying into concentration behind the mixing is that 50% ethanol is an amount of, processes soft material, soft material through extruding granulate wet granular, the granulation sieve number is 10 orders.Must do granule behind the gained wet grain drying, then volatile oil evenly sprayed in the dried granule, promptly get Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae after airtight a period of time.
Instructions of taking: each 5 grams, every day three times, warm boiled water.Food avoids pungent food.
Embodiment 3: Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae, prescription is: Radix Puerariae 800 g, Flos puerariae lobatae 200 g, Radix Notoginseng 12 g, Radix Ophiopogonis 150 g, the Radix Angelicae Dahuricae 150 g, Rhizoma Coptidis 50 g, Radix Scutellariae 100 g, Cortex Phellodendri 300 g, Radix Glycyrrhizae 200g.
Method for preparing:
The first step: with after the Radix Puerariae chopping, add 5 times of water gagings of Radix Puerariae and soak 1 hour post-heating to 100 ℃, continue heating, reflux, extract, 0.5 hour is filtered, and collects filtrating; The Pueraria lobota slag adds 8 times of water gagings of raw material, and heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Radix Puerariae concentrated solution that relative density is 1.16 (50 ℃);
With adding 6 times of amount concentration after the Flos puerariae lobatae coarse pulverization is that 50% alcohol heating reflux extracted 1 hour, filters, and collects filtrating; 8 times of amounts of adding raw material concentration is 50% alcoholic solution in the Flos puerariae lobatae filtering residue, and heating and refluxing extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Flos puerariae lobatae extractum that relative density is 1.33 (50 ℃); Flos puerariae lobatae extractum mixes the back with the Radix Puerariae concentrated solution spray-dried, gets Radix Puerariae-Flos puerariae lobatae extract mixture dry powder;
Second step: Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, and it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; The decocting that adds for the first time 10 times of amounts boiled 1 hour; The decocting that adds for the second time 8 times of amounts boiled 1 hour; Filter, merging filtrate, concentrating under reduced pressure get mixture extractum Radix Ophiopogonis that relative density is 1.28 (50 ℃);
The 3rd step: Radix Notoginseng powder is broken into fine powder, crosses 80 mesh sieves;
The 4th step: get cane sugar powder 450 grams, dextrin 300 grams, Radix Puerariae-Flos puerariae lobatae mixture dry powder 180 gram mixings; Get Radix Notoginseng powder 12 gram, adopt the equivalent method of progressively increasing to add, mixing adds mixture extractum 50 grams Radix Ophiopogonis, and spraying into concentration is that 50% ethanol is an amount of, processes soft material, soft material through extruding granulate wet granular, the granulation sieve number is 20 orders.Must do granule behind the gained wet grain drying, then volatile oil evenly sprayed in the dried granule, promptly get Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae after airtight a period of time.
Instructions of taking: each 5 grams, every day three times, warm boiled water.Food avoids pungent food.
Embodiment 4: Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae, prescription is: Radix Puerariae 800 g, Flos puerariae lobatae 200 g, Radix Notoginseng 20 g, Radix Ophiopogonis 150 g, the Radix Angelicae Dahuricae 150 g, Rhizoma Coptidis 50 g, Radix Scutellariae 100 g, Cortex Phellodendri 200 g, Radix Glycyrrhizae 180g.
Method for preparing:
The first step: with after the Radix Puerariae chopping, add 5 times of water gagings of Radix Puerariae and soak 1 hour post-heating to 100 ℃, continue heating, reflux, extract, 0.5 hour is filtered, and collects filtrating; The Pueraria lobota slag adds 8 times of water gagings of raw material, and heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Radix Puerariae concentrated solution that relative density is 1.22 (50 ℃), and concentrated solution is spray-dried, get powder of Radix Puerariae;
Flos puerariae lobatae is pulverized the back, and to add 6 times of amount concentration be 1 hour post-heating reflux, extract, of 70% soak with ethanol 1 hour, filters, and collects filtrating; Add 8 times of water gagings of raw material in the Flos puerariae lobatae slag, heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Flos puerariae lobatae extractum that relative density is 1.31 (50 ℃); Extractum gets the Flos puerariae lobatae extract powder through crushed after being dried;
Second step: Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, and it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; The decocting that adds for the first time 10 times of amounts boiled 1 hour; The decocting that adds for the second time 8 times of amounts boiled 1 hour; Filter, merging filtrate, concentrating under reduced pressure get mixture extractum Radix Ophiopogonis that relative density is 1.25 (50 ℃); Extractum gets mixture extract dry powder Radix Ophiopogonis through crushed after being dried;
The 3rd step: Radix Notoginseng powder is broken into fine powder, crosses 80 mesh sieves;
The 4th step: get dextrin 550 grams, Celluloasun Microcrystallisatum 200 grams, powder of Radix Puerariae 160 grams, mixing; Other gets Radix Notoginseng powder 20 gram, Flos puerariae lobatae extract dry powder 20 grams, Radix Ophiopogonis mixture extract dry powder 50 grams, an amount of mixing of steviosin; Be that 50% ethanol is an amount of with spraying into concentration behind these two kinds of mixed-powder mixings again, process soft material, soft material through extruding granulate wet granular, the granulation sieve number is 10 orders.Must do granule behind the gained wet grain drying, then volatile oil evenly sprayed in the dried granule, promptly get Sugarless type Radix Puerariae, the anti-oral ulcer granule of Flos puerariae lobatae after airtight a period of time.
Instructions of taking: each 5 grams, every day three times, warm boiled water.Food avoids pungent food.
Embodiment 5: Radix Puerariae, the anti-oral ulcer effervescent granule of Flos puerariae lobatae, prescription is: Radix Puerariae 900 g, Flos puerariae lobatae 150 g, Radix Notoginseng 18 g, Radix Ophiopogonis 150 g, the Radix Angelicae Dahuricae 150 g, Rhizoma Coptidis 50 g, Radix Scutellariae 100 g, Cortex Phellodendri 250 g, Radix Glycyrrhizae 200g.
Method for preparing:
The first step: with after the Radix Puerariae chopping, add 5 times of water gagings of Radix Puerariae and soak 1 hour post-heating to 100 ℃, continue heating, reflux, extract, 0.5 hour is filtered, and collects filtrating; The Pueraria lobota slag adds 8 times of water gagings of raw material, and heating extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Radix Puerariae concentrated solution that relative density is 1.18 (50 ℃), and concentrated solution is spray-dried, get powder of Radix Puerariae;
With adding 6 times of amount concentration after the Flos puerariae lobatae coarse pulverization is that 70% alcohol heating reflux extracted 1 hour, filters, and collects filtrating; 8 times of amounts of adding raw material concentration is 70% ethanol in the Flos puerariae lobatae slag, and heating and refluxing extraction 1 hour is filtered, and collects filtrating; Merging filtrate, concentrating under reduced pressure obtain the Flos puerariae lobatae extractum that relative density is 1.32 (50 ℃); Flos puerariae lobatae extractum gets Flos puerariae lobatae extract dry powder after drying, pulverizing;
Second step: Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, and it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; The decocting that adds for the first time 10 times of amounts boiled 1 hour; The decocting that adds for the second time 8 times of amounts boiled 1 hour; Filter, merging filtrate, concentrating under reduced pressure get mixture extractum Radix Ophiopogonis that relative density is 1.30 (50 ℃); Extractum gets mixture extract dry powder Radix Ophiopogonis through crushed after being dried;
The 3rd step: Radix Notoginseng powder is broken into fine powder, crosses 80 mesh sieves;
The 4th step: get sodium bicarbonate 60 grams, Flos puerariae lobatae extract dry powder 10 grams, Radix Notoginseng powder 10 grams, Radix Ophiopogonis extract dry powder 50 gram mixings; Other gets cane sugar powder 200 grams, dextrin 350 grams, Radix Puerariae extract dry powder 180 grams, citric acid 140 gram mixings; Again with these two kinds of powder mixings, it is an amount of to spray into concentration and be 50% ethanol, processes soft material, soft material through extruding granulate wet granular, the granulation sieve number is 20 orders.Must do granule behind the gained wet grain drying, then volatile oil evenly sprayed in the dried granule, promptly get Radix Puerariae, the anti-oral ulcer effervescent granule of Flos puerariae lobatae after airtight a period of time.
Instructions of taking: each 5 grams, every day three times, warm boiled water.Food avoids pungent food.
Embodiments of the invention are merely limited preferred embodiment, for the conversion of the equivalent technologies characteristic that does not break away from technical scheme essence of the present invention, are regarded as the category of claim protection of the present invention.
Claims (4)
1. the anti-oral ulcer granule of Radix Puerariae Flos puerariae lobatae is characterized in that mainly consisting of: the Radix Puerariae of 700-900 weight portion, the Flos puerariae lobatae of 100-200 weight portion; The Radix Notoginseng of 10-20 weight portion, the Radix Ophiopogonis of 100-200 weight portion, the Radix Angelicae Dahuricae of 100-200 weight portion; The Rhizoma Coptidis of 50-100 weight portion; The Radix Scutellariae of 100-150 weight portion, the Cortex Phellodendri of 200-300 weight portion, the Radix Glycyrrhizae of 150-200 weight portion.
2. the anti-oral ulcer granule of Radix Puerariae Flos puerariae lobatae according to claim 1 is characterized in that: said Radix Puerariae is the tuber of legume pueraria lobata or Pachyrhizua angulatus; Flos puerariae lobatae is the alabastrum of legume pueraria lobata or Pachyrhizua angulatus; Be the Liliaceae herbaceos perennial dry tuber of Radix Ophiopogonis Radix Ophiopogonis; Radix Notoginseng is the perennial panax species Radix Notoginseng of an Araliaceae rhizome; The Radix Angelicae Dahuricae is the dry root of the samphire Radix Angelicae Dahuricae; Rhizoma Coptidis is the dry rhizome of cohosh Rhizoma Coptidis; Radix Scutellariae is the dry root of Labiatae Scutellaria Radix Scutellariae; Cortex Phellodendri is the dry bark of Rutaceae perennial woody plant Cortex Phellodendri; Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume.
3. one kind prepares the particulate method of the anti-oral ulcer of Radix Puerariae Flos puerariae lobatae according to claim 1, it is characterized in that comprising the step of following order:
(1) prepares following proportion raw material: the Radix Puerariae of 700-900 weight portion, the Flos puerariae lobatae of 100-200 weight portion, the Radix Notoginseng of 10-20 weight portion; The Radix Ophiopogonis of 100-200 weight portion; The Radix Angelicae Dahuricae of 100-200 weight portion, the Rhizoma Coptidis of 50-100 weight portion, the Radix Scutellariae of 100-150 weight portion; The Cortex Phellodendri of 200-300 weight portion, the Radix Glycyrrhizae of 150-200 weight portion;
(2) with after the raw material Radix Puerariae chopping, be incorporated as water logging bubble 1-2 hour post-heating to 100 that Radix Puerariae volume 5-10 doubly measures ℃, continue heating, reflux, extract, 0.5-1 hour, filter, collect filtrating; The Pueraria lobota slag is incorporated as the water that Pueraria lobota slag volume 5-10 doubly measures again, continues heating extraction 1-1.5 hour, filters, and collects filtrating; Merge above filtrating, relative density is 1.10-1.20 when being evaporated to 50 ℃, gets the Radix Puerariae concentrated solution; Concentrated solution is spray-dried, gets Radix Puerariae dry powder;
(3) the raw material Flos puerariae lobatae is pulverized after, be incorporated as the water that Flos puerariae lobatae volume 5-10 doubly measures or the mixed solution of second alcohol and water and soaked 0 ~ 1 hour, wherein, concentration of alcohol is 50%-70%, heating and refluxing extraction 0.5-1 hour then, filter, collect filtrating; Be incorporated as the water that filtering residue volume 5-10 doubly measures in the filtering residue, continued heating extraction 1-1.5 hour, filter, collect filtrating; Merge above filtrating, relative density is the extractum of 1.30-1.35 when being evaporated to 50 ℃, gets Flos puerariae lobatae extractum; Extractum gets the Flos puerariae lobatae extract dry powder through crushed after being dried;
(4) Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, glycyrrhizic liuwei drug material are extracted volatile oil, it is subsequent use to get volatile oil; With Radix Ophiopogonis, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae decocte with water behind the extraction volatile oil 2 times; Being incorporated as for the first time the decocting that raw material cumulative volume 8-10 doubly measures boiled 1-2 hour; Filter, be incorporated as the decocting that raw material cumulative volume 8-10 doubly measures for the second time and boiled 1-2 hour, filter; Merge filtering filtrating twice, relative density is the mixture extractum such as Radix Ophiopogonis of 1.25-1.30 when being evaporated to 50 ℃; Extractum gets mixture extract dry powder such as Radix Ophiopogonis through crushed after being dried;
(5) the raw material Radix Notoginseng powder is broken into fine powder, crosses the 80-100 mesh sieve;
(6) with an amount of adjuvant, with from step (2), extract the Radix Puerariae dry powder obtain, step (3) in extract mixture extract dry powder such as extracting Radix Ophiopogonis of obtaining in the Flos puerariae lobatae extract dry powder that obtains, the step (4) and the Radix Notoginseng fine powder mixes; Perhaps, the Radix Puerariae concentrated solution that step (2) is obtained, the Flos puerariae lobatae extractum that step (3) obtains, that mixture extractum Radix Ophiopogonis that step (4) obtains mixes the back is spray-dried, obtain extract mixtures dry powder after, mix with Radix Notoginseng fine powder and an amount of adjuvant again; Perhaps; The Radix Puerariae concentrated solution that step (2) is obtained mixes back spray-dried with the Flos puerariae lobatae extractum that step (3) obtains; Radix Puerariae Flos puerariae lobatae extract mixture dry powder, obtain with step (4) again Radix Ophiopogonis mixture extractum and Radix Notoginseng fine powder and an amount of adjuvant mix; Wherein, the quality summation of medicinal raw material is 1:3.0 ~ 1:3.5 with the ratio of adjuvant quality summation; In mixed process, measure few composition and adopt the equivalent method of progressively increasing to add; After the mix homogeneously, spray into concentration and be 50% ethanol, process soft material, soft material is granulated through extruding and is obtained wet granular, and the granulation sieve number is the 10-20 order; Must do granule behind the gained wet grain drying, then step (4) gained volatile oil evenly sprayed in the dried granule, promptly get the anti-oral ulcer granule of Radix Puerariae Flos puerariae lobatae after airtight a period of time.
4. according to the particulate method of the anti-oral ulcer of the said preparation Radix Puerariae of claim 3 Flos puerariae lobatae, it is characterized in that: said adjuvant is one or more in cane sugar powder, dextrin, Celluloasun Microcrystallisatum, steviosin, sodium bicarbonate, the citric acid.
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| CN110381971A (en) * | 2017-03-07 | 2019-10-25 | 株式会社Lg生活健康 | Composition is used in the improvement of Menopause symptom |
| CN116350686A (en) * | 2023-01-31 | 2023-06-30 | 云南省药物研究所 | Medicinal and edible traditional Chinese medicine composition for treating dental ulcer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110381971A (en) * | 2017-03-07 | 2019-10-25 | 株式会社Lg生活健康 | Composition is used in the improvement of Menopause symptom |
| CN116350686A (en) * | 2023-01-31 | 2023-06-30 | 云南省药物研究所 | Medicinal and edible traditional Chinese medicine composition for treating dental ulcer and preparation method thereof |
| CN116350686B (en) * | 2023-01-31 | 2023-12-12 | 云南省药物研究所 | Medicinal and edible traditional Chinese medicine composition for treating dental ulcer and preparation method thereof |
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