CN107951951B

CN107951951B - Traditional Chinese medicine composition for removing senile plaques and preparation method thereof

Info

Publication number: CN107951951B
Application number: CN201810071340.1A
Authority: CN
Inventors: 向昌荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-01-25
Filing date: 2018-01-25
Publication date: 2021-04-13
Anticipated expiration: 2038-01-25
Also published as: CN107951951A

Abstract

The invention discloses a traditional Chinese medicine composition for removing senile plaques, which comprises the following oral medicine raw materials: 3-6 parts of radix aconiti kusnezoffii, 1-3 parts of caulis spatholobi, 2-4 parts of castoreum fruit, 1-2 parts of ginkgo, 1-2 parts of rehmannia, 1-2 parts of astragalus membranaceus and 1-2 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines: 5-7 parts of radix aconiti kusnezoffii, 3-5 parts of radix tinosporae and 2-4 parts of radix sophorae flavescentis. The medicine of the invention is scientifically matched, has strong efficacy, rapid efficacy and stable efficacy, and has the efficacies of clearing away heat and toxic material, removing heat from the blood, promoting blood circulation to remove blood stasis and the like. The medicine has unique treatment effect on senile plaque, and has obvious treatment effect on freckle, chloasma, sunburn, cyasma and pigmented spots of middle-aged and young people. The medicine also has the characteristics of unique formula, small dosage, quick response, obvious curative effect and the like, and the effective rate of treatment is more than 86% through clinical verification.

Description

Traditional Chinese medicine composition for removing senile plaques and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for removing senile plaques and a preparation method thereof.

Background

The senile plaques are brownish black, the diameters of the senile plaques are mostly between 1 mm and 10 mm, the senile plaques are different in size, the diameters of large plaques can reach 2-3 cm, most of the senile plaques are not higher than the skin, and some of the senile plaques are higher than the skin and are flat. Senile plaques are not only found in the skin, but also in the heart, blood vessels, liver, and the internal glands, which affect the normal functions of the organs.

Cause of senile plaque: the appearance of age spots is a manifestation of a decline in cell function, which is formed by the accumulation of certain waste products during the metabolism of the cells, including "lipid peroxide" amino acid residues and insoluble sludge formed by the condensation of amino acids and other components.

First, after entering the elderly, the metabolism of cells is reduced, the body fat is easily oxidized to produce pigment for the elderly, and the pigment cannot be discharged out of the body and then is deposited on the cell body, thereby forming the elderly.

Secondly, after the aged, the metabolism in the body begins to go downhill, the decline of the cell function is accelerated year by year, the blood circulation also tends to be slow, and the aged changes and exercises on the dietary structure and the proportion of the plant fat intake is disordered, and other reasons promote that a tiny brown particle called lipofuscin is accumulated in basal layer cells of the skin, the brown particle is a product in the process of lipid peroxidation, and aged histiocyte loses the function of decomposition and rejection, so that excessive brown particles are accumulated in the basal layer of local cells, thereby forming senile plaques on the surface of the human body.

And thirdly, the activity of superoxide dismutase with anti-peroxidation effect in the elderly is reduced, the free radicals are relatively increased, and the free radicals and the induced peroxidation reaction are toxic to organisms for a long time. In addition, the formation and abundance of senile plaques are influenced by various factors, some are related to congenital genetic factors, some are related to deficiency of certain nutritional factors, and some are related to certain physical factors.

The damage of age spots: it is found not only in the skin but also in the heart, blood vessels, liver and endocrine glands, which affect the normal functions of the organs. It has no major influence on health, but seriously affects beauty-internal youth and external aging, so it is needed to prevent and treat early, so it is not too early to prevent yellow face and grandmother's age.

At present, the treatment of senile plaques in modern medicine is usually carried out by using a carbon dioxide laser, liquid nitrogen freezing, an erbium laser, scraping or surgical excision method, and although the symptoms can be effectively relieved, the treatment process is slow and the treatment cost is high. Some external products such as spot-removing facial masks, spot-removing creams, lotions and the like appear on the market, but the skin barriers and the skin spot forming mechanisms are different, so that the symptoms are treated, the root causes are not treated, and some hormone-containing products have great harm to the skin; unlike the external products, the oral products such as vitamin E are convenient to use, but have poor effect, and the long-term administration of the products can not lead to metabolism of human bodies and cause poisoning.

Disclosure of Invention

In order to overcome the defects of slow treatment course, high treatment cost, large body injury and the like in the prior art for treating the senile plaques, the invention provides the seedling Chinese medicinal composition for removing the senile plaques, which has the advantages of small dosage, low cost, quick response, safety and reliability, and the preparation method thereof.

According to the blunderbuss traditional Chinese medicine theory and the modern medicine theory, aiming at the mechanism and the treatment principle of senile plaque, on the basis of inheriting the secret prescription handed down from the ancestors of the Miao nationality, the inventor obtains the medicine through screening and summary of more than thirty years of intensive research. The medicine is divided into an oral administration part and an external application part, and when the medicine is used, the oral administration is matched with the external application, and the method of oral administration and external application is adopted, and the external application is mainly used. The traditional Chinese medicine composition has the main functions of clearing heat and removing toxicity, enriching blood and tonifying qi and regulating nutrition, and has the main functions of clearing heat and removing toxicity, clearing blood and cooling blood and promoting blood circulation and removing blood stasis.

The traditional Chinese medicine composition for treating senile plaque comprises an oral medicine and an external medicine, wherein the oral medicine comprises the following raw material medicines in parts by weight: 3-6 parts of radix aconiti kusnezoffii, 1-3 parts of caulis spatholobi, 2-4 parts of castoreum fruit, 1-2 parts of ginkgo, 1-2 parts of rehmannia, 1-2 parts of astragalus membranaceus and 1-2 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 5-7 parts of radix aconiti kusnezoffii, 3-5 parts of radix tinosporae and 2-4 parts of radix sophorae flavescentis.

The inventor finds that the senile plaque can be obviously removed by selecting a specific formula of oral and external medicines for combined use, the traditional Chinese medicine composition for treating the senile plaque comprises the oral medicine and the external medicine, and the oral medicine comprises the following raw materials in parts by weight: 3 parts of radix aconiti kusnezoffii, 1 part of caulis spatholobi, 2 parts of castoreum fruit, 1 part of ginkgo, 1 part of rehmannia root, 1 part of astragalus membranaceus and 1 part of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 6 parts of radix aconiti kusnezoffii, 2 parts of radix tinosporae and 2 parts of radix sophorae flavescentis.

In order to solve the technical problems, the invention also provides a preparation method of the traditional Chinese medicine composition for removing the senile plaques, and the preparation method of the oral medicine comprises the following steps: a. mixing the oral medicine of radix Linderae, caulis Sargentodoxae, fructus raccoon, semen Ginkgo, rehmanniae radix, radix astragali and Saviae Miltiorrhizae radix according to the formula, pulverizing, adding 10-15 times of water, soaking for 2-3 hr, heating, decocting, and slightly boiling for leaching to obtain decoction and residue; b. adding 10-15 times of water, and decocting the residue in step a for 2-3 times to obtain 2-3 times decoction; c. mixing the decoctions obtained in the step a and the step b, settling, filtering, concentrating, and freeze-drying to obtain active components of the oral medicine; d. and c, adding pharmaceutically acceptable auxiliary materials into the active components of the oral medicament obtained in the step c to prepare any pharmaceutically acceptable oral dosage form.

Or drying and crushing the active components of the internal medicine obtained in the step c, and sieving the crushed active components with a 100-mesh and 120-mesh sieve.

The active components of the oral medicine are added with pharmaceutically acceptable auxiliary materials to prepare a pharmaceutically acceptable oral preparation. For example, adding filler, adhesive, disintegrating agent, etc. to make into any common oral dosage form, such as pill, granule, tablet, capsule, etc. by conventional Chinese medicinal preparation method.

Preferably, the oral medicament is a big honeyed pill, and the preparation method comprises the steps of mixing, drying and crushing the oral medicament of radix linderae, spatholobus stem, castanopsis mollis, ginkgo biloba, rehmannia root, astragalus root and salvia miltiorrhiza to fine powder according to a formula, sieving the fine powder by a 120-mesh sieve, weighing honey according to a weight ratio of 1:5, heating the honey in an evaporation dish to boil, refining the honey, mixing the refined honey with the medicinal powder according to a ratio, and preparing the mixture into the big honeyed pill for administration.

In order to solve the technical problems, the invention also provides a preparation method of the traditional Chinese medicine composition for removing the senile plaques, the preparation form of the externally applied medicine is medicinal liquor, and the preparation method comprises the following steps: mixing the topical medicines of radix Linderae, radix tinosporae and radix Sophorae Flavescentis according to the formula, pulverizing, placing into a container, adding 2-5 times of 35-45 ° wine, sealing, soaking for 3-5 days, and collecting supernatant and applying to affected part.

Preferably, the invention further provides a preparation method of the traditional Chinese medicine composition for removing the senile plaques, the external application medicine is powder, and the preparation method comprises the following steps: mixing the externally applied medicines of radix aconiti kusnezoffii, radix tinosporae and radix sophorae flavescentis according to a formula, crushing, putting into a container, adding pharmaceutically acceptable auxiliary materials of a filler and a lubricant, fully mixing, and sieving by a sieve of 100 meshes and 120 meshes to obtain powder.

In the technical scheme, the external application medicament can also be water agent and cream. Mixing the topical medicines including radix Linderae, radix tinosporae and radix Sophorae Flavescentis according to the formula, pulverizing, placing in a container, adding water solvent or dispersant, and stirring thoroughly.

The beneficial technical effects of the invention comprise the following points:

(1) the medicine has the advantages of convenient administration, direct effect on the focus of a patient, easy preparation and low cost;

(2) the medicinal materials are pure natural, scientific in compatibility, few in medicinal materials, safe and free of toxic and side effects, and an ideal treatment effect can be achieved;

(3) the formula is novel, and the Miao medicine is taken as the basis and is combined with the traditional Chinese medicine to play the roles of treating both symptoms and root causes, clearing heat and detoxicating, enriching blood and tonifying qi, clearing blood and cooling blood and activating blood and dissolving stasis.

(4) The medicine of the invention has scientific compatibility, strong efficacy, rapid efficacy and stable efficacy, not only has unique treatment efficacy on senile plaque, but also has significant treatment efficacy on freckle, chloasma, sunburn, cyasma and pigmented spots of middle-aged people, and the treatment effective rate is up to 86 percent proved by more than 160 clinical cases.

Detailed Description

From the perspective of traditional Chinese medicine, the internal organs of the body are qi stagnation and blood stasis, the internal organs of the body are full of essence, the skin is delicate and glossy, the essence of the internal organs of the body is deficient, and the skin is cachectic and withered, according to the method of ' external drinking and internal drinking ' in the traditional Chinese medical classic ' Huangdi internal classic, only internal regulation and external treatment can be performed, both the symptoms and root causes can be treated, and the cure can be thoroughly realized. The formula of the invention is provided by combining the application principles of Miao medicine plant application, wherein hot medicine can treat cold diseases, cold medicine can treat heat diseases, and medicine can tonify physique and treat deficiency diseases.

Black-bubble morphology, shrub, up to 3 meters; thick stem, yellow villous velveteen and sparse hook-like small skin prickles. The single leaf is nearly round, the diameter is 7-16 cm, the tip is round and blunt or sharp, the base is heart-shaped, the upper surface is provided with soft hair and dense small bulges, the lower surface is densely covered with yellow gray or yellow villi, the soft hair is arranged along the leaf vein, the edge is palm-shaped and has 7-9 shallow cracks, the top crack is not obvious and has 3 cracks, irregular and coarse sawteeth are arranged, the base has palm-shaped 5-out pulses, and the network pulse is obvious; the leaf stalk is 3-6 cm long and is densely covered by yellow villous soft hair and small skin prickles; the supporting leaves are wider, are wide in ellipse or wide in inverted oval, have comb-shaped deep cracks at the top ends, and have needle-shaped or linear needle-shaped cracks without splitting. The terminal generation narrow cone inflorescence or the total inflorescence, and the axillary generation inflorescence is the total shape or the flower cluster set; the thick covers of the total pedicel, pedicel and calyx are yellow or yellow white silk-like long and soft hair; the flower stalk is 1-1.5 cm long and thin and long; the bract is wide and big, and is shaped like a leaf, and the palm is cracked; the diameter of the flower is 1.5-2.5 cm; the sepals are wide and oval, the tops of the sepals are tapered, the edges of the sepals sometimes have villi, the sepals are usually wide and large, the top of the sepals are divided from palmar to pinnate, the sepals are rare and not split, the sepals are long and narrow, and are not split or split, and the sepals are upright in the fruit stage; the petals are inverted egg-shaped or spoon-shaped, white and provided with claws; most stamens, wide and flat filaments, and a few long and soft anthers; there are many pistils and the ovaries are hairless. The fruit is spherical, the diameter can reach 2 cm, and the fruit is red; the nucleus had significant wrinkles. The flowering period is 4-6 months, and the fruit period is 8-9 months.

[ Latin name ] the original plant Rubus multibacteatus Levl.

[ alias ] Dahong Huangpao, Wupao thorn, August bubble, Wulong tail, Chuanjiang dragon and Zaocys

[ PRODUCT ] Rubus multibacteatus Levl. et Vant of Rubus of Rosaceae is used as the root and whole plant. Collected all the year round and dried in the sun.

[ PROPERTIES AND WESTERN CHANNELS ] bitter in flavor and cool in spleen and liver meridians

[ FUNCTIONS ] can clear away heat, promote diuresis, stop bleeding, and heal fracture. Can be used for treating common cold, fever, enteritis, dysentery, hemoptysis, epistaxis, and rheumatalgia.

[ EXTRACTION ] COLOUR OF CHINESE MEDICINAL HERBS

The functions are mainly used for clearing away heat and toxic materials, dispelling wind and removing dampness; clear blood and cool blood, activate blood and stop bleeding, and heal bone. It can be used for treating dysentery, diarrhea, rheumatalgia, hemoptysis, female menorrhea, and fracture.

Caulis Kadsurae Longipedunculatae is caulis and root of Schisandra sphenanthera of Schisandraceae.

[ PROPERTIES AND FLAVOURS ] XIN; sexual temperature

[ FUNCTIONS ] can be used for treating rheumatic arthritis, dispelling pathogenic wind, and removing dampness; promoting qi circulation and relieving pain; promoting blood circulation to stop bleeding. Chief wind-damp arthralgia; pain in the heart and stomach; hematemesis due to tuberculosis; amenorrhea; menoxenia; traumatic injury; pyogenic infections of incised wound

[ extract ] China materia Medica

Dan Shen is bitter in taste and slightly cold in nature. It enters heart and liver meridians.

[ efficacy and pharmacology ]

1. Dan Shen is good at activating blood and resolving stasis, and is a commonly used herb for activating blood and resolving stasis. Compendium of materia Medica is called: red Dan Shen is red in color and bitter in taste, flat and descending in flavor, and yang in yin … … can also reduce blood. Salvia miltiorrhiza, which activates blood and removes stasis, is mainly related to its action on the blood system and cardiovascular and cerebrovascular systems.

Protection of cerebral ischemia

② improving coronary circulation

③ protection against myocardial ischemia and myocardial infarction

Improving microcirculation

Fifth to influence on the cardiovascular system

Sixthly, reducing blood fat and resisting atherosclerosis

Influence on blood

2. Heart nourishing and tranquilization, Shen Dan from Jing Yue quan Shu, also can nourish yin and calm mind, tonify qi and relieve restlessness. Its heart nourishing and mind tranquilizing effects are related to central tranquilizing action.

3. Blood cooling and pain relieving for red sage root from Rihua Zi Cao (Rihua Zi Cao) can be used for treating malignant sore, scabies, goiter, tumor, swelling and erysipelas, etc., and blood cooling and pain relieving for red sage root is mainly manifested in terms of antibiosis and antiphlogosis.

4. Pus discharge and tissue regeneration promoting function of Dan Shen from Jing Yue quan Shu (full book of Jing Yue) is to expel pus, stop pain, promote granulation.

5. Hypoxia tolerance

6. Action on the liver

7. Resisting peptic ulcer

8. Antitumor agent

9. Action on the lungs

10. Others

The main indications are irregular menstruation, menstrual pain, amenorrhea, abdominal mass, postpartum blood stasis, pain of chest and abdomen or limb blood stasis, pain and swelling, sore and toxin, vexation, insomnia and the like

The raccoon is sour and sweet in taste and mild in nature. It enters liver, gallbladder and heart meridians.

[ efficacy and pharmacology ]

1. Tranquilizing mind by nourishing the heart

Tranquilizing and hypnotizing, relieving pain and convulsion and cooling.

2. Effects on the cardiovascular System

Anti-arrhythmic action

② improving myocardial ischemia and reducing ischemic myocardial damage

Effect of improving cerebral ischemia

Lowering blood pressure

3. Blood lipid reducing effect

4. Influence on immune function and anti-radiation injury effect

5. Anti-lipid peroxidation

6. Others

[ indications ] restlessness, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid consumption and thirst

Huang Qi is sweet in flavor and slightly warm in nature. It enters lung and spleen meridians.

[ efficacy and pharmacology ]

1. Astragalus root, radix astragali, being sweet and warm in nature, is the essential herb for tonifying qi, and can tonify qi. Pearl sac (pearl sac) is characterized by: the astragalus root, radix astragali, sweet in taste and warm in nature, is used for treating the diseases of five types: to remedy deficiency, one is also; benefiting primordial qi, and two also; strengthening the spleen and stomach, and strengthening the spleen and stomach; muscle heat removal, also four; pus discharge and pain relief, blood circulation and generation of blood, deep rooted carbuncle of yin type, are the hallucination medicine of sore. Its qi-tonifying action is related to its action of enhancing immunity, strengthening heart and affecting gastrointestinal function.

2. The traditional Chinese medicine considers that qi and blood are homologous, the blood is the mother of qi, and the qi is the commander of the blood, namely the qi and the blood can mutually influence, the qi can generate the blood, and the blood circulation depends on the promotion of the qi; qi circulation is followed by blood circulation, qi stagnation is followed by blood stasis, and Huang Qi is the holy drug for tonifying qi, so Huang Qi can tonify qi and blood, and has the actions of removing blood stasis and dissipating nodulation. Its action is mainly manifested by the influence on the blood system and hemorheology.

3. Yi Wei Gu exterior (from medical Source): astragalus root is used for spontaneous sweating due to consumptive disease, tonifying lung qi, excess fur, purging pus and middle fire, and wiry pulse spontaneous sweating. Huang Qi is sweet and warm, and is mainly indicated for tonifying qi of lung and spleen, and for strengthening the exterior and stopping sweating. Its action mainly shows the aspects of raising immunity of human body and resisting virus, etc.

4. Traditional Chinese medicine for strengthening body and prolonging life considers that the deficiency of kidney qi and spleen qi is the main reason for aging. Astragalus root is the holy drug for invigorating qi. It is thought to have anti-aging effect because it can tonify spleen qi and tonify lung qi.

5. Other effects

The main indications are qi deficiency and hypodynamia, poor appetite and loose stool, collapse of middle-jiao energy, chronic diarrhea and rectocele, hematochezia and metrorrhagia, superficial deficiency and spontaneous perspiration, edema due to qi deficiency, pain and deep rooted carbuncle which are difficult to ulcerate, chronic ulceration which is not convergent, blood deficiency and sallow complexion, internal heat and thirst quenching.

Ginkgo has sweet, bitter and astringent taste and mild property. It enters lung and kidney meridians.

[ efficacy and pharmacology ]

1. The ginkgo leaves which benefit heart and astringe lung can treat chest distress and heartache, palpitation, severe palpitation, phlegm asthma, cough and other symptoms.

2. Promoting blood circulation to arrest pain

3. Prolonging life and promoting intelligence

4. Others

[ indications ] chest distress and cardiodynia, palpitation, phlegm asthma and cough, diarrhea and white leukorrhea

Rehmannia root, radix rehmanniae is sweet and bitter in taste and cold in nature. It enters heart, liver and kidney meridians.

[ efficacy and pharmacology ]

1. Clearing heat and cooling blood, nourishing Yin and promoting the production of body fluid, this herb Hei Yuan from Ben Cao Yuan (materia Medica) means that it is indicated for cooling blood and nourishing Yin internally, moistening skin and moistening skin externally, and it should be added for patients with deficiency and heat. It is called as the key herb of kidney tonifying family and the superior product for nourishing yin and blood in Ben Cao Jing Shu (materia Medica of Prateness management and Dredging). The efficacy is related to the following.

Influence on the syndrome of yin deficiency of hyperthyroidism

② the influence on the yin deficiency syndrome of adrenocortical hormone

Influence on blood sugar

Hypertension relieving effect

Influence on blood coagulation and rheology

Anti-radiation damage effect

2. Sheng Xue (one herb through various records) says that it is specialized in tonifying blood, tonifying blood leading to the harmonization of yin and qi without the symptoms of dryness and spasm. "its hematopoiesis function is related to its action of promoting hematopoiesis.

3. Other effects

Enhancing the immune function of the organism

② antitumor action

③ strengthening heart and inducing diuresis

Sedative hypnotic effect

The liver-protecting function

Anti-inflammatory action

(ii) antioxidation

The main indications are heat fire damaging yin, tongue lowering polydipsia, macula and eruption, hematemesis, epistaxis blood and swollen and sore throat. Sheng Di Huang is indicated for fever with thirst, yin deficiency with internal heat, bone-steaming with internal heat, internal heat with thirst, hematemesis, epistaxis, macula and eruption. Prepared rehmannia root, radix rehmanniae Praeparata has the effects of nourishing yin and blood, and replenishing essence and marrow. Can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, severe palpitation, menoxenia, metrorrhagia, metrostaxis, hemorrhage, giddiness, tinnitus, and early white beard and hair.

The name of radix tinosporae is traditional Chinese medicine. Dried root tuber of Tinospora cordifolia or Tinospora cordifolia of Menispermaceae family. Collected in autumn and winter, removed fibrous root, cleaned and dried in the sun. Is bitter and cold in nature, and has the effects of clearing away heat and toxic materials, relieving sore throat and alleviating pain. Can be used for treating swelling and pain of throat, carbuncle, furuncle, diarrhea, dysentery, and abdominal pain. Plant name: radix tinosporae: radix Tinosporae.

[ PROPERTIES, WESTERN AND GUIJING ] is bitter and cold. It enters lung and large intestine meridians.

[ FUNCTIONS AND INDICATIONS ] can clear away heat and toxic materials, relieve sore throat, and relieve swelling and pain. Can be used for treating swelling and pain of throat, carbuncle, furuncle, diarrhea, dysentery, and abdominal pain due to heat. Clearing away heat and toxic material. Treating acute and chronic tonsillitis, acute pharyngolaryngitis, stomatitis, parotitis, mastitis, appendicitis, superficial infection, furuncle, acute and chronic enteritis, bacillary dysentery, gastralgia, and aphonia due to hot cough.

(1) Examination of drug Properties: "detoxification". It is suitable for throat with acute arthralgia and erosion of mouth. On the back, burning red furuncle, and injuring snake, scorpion and insect, it is ground and applied. It is indicated for eye pain, ear distention, cough, glaucoma, hematemesis and other external diseases. "

(2) (Small wisdom in Tang Yuan): ' dispel interior and exterior knot heat, general body malign poison, eliminate miasma, double single laryngeal moth and toothache, slice and contain; grind and spread the furuncle swelling toxin. "

(3) The "Renzai of materia Medica": nourishing yin to reduce pathogenic fire, quenching thirst and promoting fluid production. "

(4) Luchuan Bencao: it is indicated for infantile carbuncle. "

(5) Guangzhou army 'handbook of Chinese herbal medicines for general use': clearing away heat and toxic material, relieving sore throat and alleviating pain. It can be used for treating diphtheria, acute pharyngolaryngitis, tonsillitis, cough, dysentery, traumatic injury, and snake wound. "

(6) Guangxi Chinese herbal medicine: it is used to treat acute gastroenteritis and stomatitis. "

(7) Practical Chinese herbal medicine selection in Guangxi: it is indicated for stomach ache, high fever due to exogenous pathogens, contact dermatitis, etc.

(8) For traumatic injury, scrofula, fish mouth and stool toxin, snake bite: the tinospora root is ground into juice and applied externally. ("Hunan Zhi Yao Zhi)

(9) Treating acute and chronic enteritis and bacillary dysentery: the tinospora root is sliced, dried in the sun, ground into powder and orally taken, 2 g for each time and three times a day. ("Guangxi Chinese herbal medicine new medical therapy prescription Collection)

(10) Treating infantile asthmatic bronchitis: the three-coin of radix tinosporae is decocted with water for two to three times for oral administration. (Zunyi auxiliary college of medicine (11): 17, 1971)

(11) Treating stomachache: the green ox gall is sliced, dried in the sun and ground into powder, the dose is reduced by half for children, and the medicine is taken one time and three times a day. Raw, cold, sour and hot foods are prohibited. ("full exhibition selective edition. internal medicine)

White, powdery, narrow skin, hidden and visible cambium ring, and radial small number of ductal bundles visible on the outer edge of the wood. The taste is extremely bitter.

Clinical application

1. Can be used for treating swelling and pain of throat, cough due to lung heat, etc.

The product has the functions of clearing heat and removing toxicity, and has good efficacy for treating red swelling and pain of throat and even fever by decocting one product or two products; for cough due to lung heat with yellow and thick sputum, it is combined with phlegm-resolving and cough-relieving herbs such as Qian Hu, fo Er Cao and Pi Pa Ye.

2. Can be used for treating swelling and pain due to heat furuncle.

It is bitter and cold in property, can clear heat and remove toxicity, cool blood and relieve swelling, and is indicated for heat furuncle, carbuncle and swelling, etc. besides being decocted for oral administration, it can also be smashed with fresh herbs for external application. For traumatic hemorrhage, the powder can be ground from hay and wrapped by spreading; for swelling and pain due to blood stasis, appropriate amount of fresh herbs is pounded and applied externally.

Radix Sophorae Flavescentis (with the scientific name of Sophora flavescens var. flavescens) is a variant of Sophora in Leguminosae. Bitter taste and cold nature. Has little toxicity. It enters heart, lung, kidney and large intestine meridians.

[ MEDICINAL HERBA PHARMACEUTICAL ] the traditional Chinese medicine radix Sophorae Flavescentis is the root of perennial deciduous shrub plant radix Sophorae Flavescentis. Produced in all parts of China. The medicine is collected in spring and autumn every year.

[ PROPERTIES AND FLAVOUR ] bitter in taste; is cold in nature.

[ GUIJING ] liver; a kidney; the large intestine; the small intestine channel; the bladder; the heart meridian; the bladder channel.

[ APPLICATION ]

1. Can be used for treating leukorrhagia and pudendal pruritus. Has good treatment effect on yellow leucorrhea of women and male vulva swelling and pruritus vulvae.

2. Treating eczema and scabies. The sophora flavescens bath can clear damp-heat in lower jiao, kill parasites and relieve itching, and has good relieving effect on skin pruritus caused by eczema and scabies.

3. Can be used for treating dysuria. The bath lotion can be used for treating dysuria, ardor and pain due to various reasons. Especially for dysuresia of women caused by pregnancy, it is effective when administered with radix Sophorae Flavescentis decoction.

[ FUNCTIONS ] can clear heat and eliminate dampness; dispel wind and kill parasites. Diarrhea and dysentery due to damp-heat; hematochezia due to intestinal wind; jaundice; difficulty in urination; edema; leucorrhea; pruritus vulvae; scabies; leprosy; itch of the skin; sores and ulcers due to damp toxin

[ discussions of the respective families ]

1. Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): ku Shen can tonify yin drastically or cause waist heaviness because it does not rise due to qi descending, so it is not called kidney injury. It is effective in treating strong wind, and has the symptoms of wind-heat and slight rash.

2. Compendium of materia Medica: ku Shen and Huang Bai are bitter and cold in property, and can tonify kidney, and cover them to remove dampness, and also clear heat. Heat generates wind and dampness generates worms, so it can be used for wind disinfestation. But those with weak kidney water and strong fire are suitable for those with strong fire, but those with weak fire and cold essence can not be used by those with high ages. Zhang from Zheng Yun, all herbs are toxic, while gan Cao and Ku Shen are not so toxic, if it is taken for a long time, the five flavors enter the zang organs, which is always the best to prevail the qi increase, all herbs are natural, so the students can feel like a touch and have a long time to drink, or the diet is also the same. It is also used to treat wind-damp-heat-removing parasites according to the theory of Shi Ji cloud and Taicang Chun-Yi-Qi-Du-Dou-Shi, moxibustion of the left-hand Yangming pulse, three liters of bitter ginseng decoction gargling every day, wind cautions in and out, and five or six days of healing.

3. The book Ben Cao Hui Yan (treatise on materia Medica): yao Fei Cheng Yun, Ku Shen, also can dispel wind and purge fire, dry dampness and remove parasites. The former is that kuh-seng tonifies kidney and tonifies yin, which is a paradox. When the medicine is bitter and fishy, the smell of yin is dry, the foul smell is hard to take, but the kidney-qi is excessive and the damp-fire is dominant; it is not advisable for those with deficiency of fire, cold essence, deficiency of original yang and those with high ages, because of stomach deficiency and weak qi. What is why the waist is heavy due to long-term taking, what is meant by the kidney injury because it is descending and ascending, is what is the effect of tonifying kidney and yin?

4. The book of hundreds of records of materia Medica: ku Shen is indicated for heart fire and has similar action to Huang Lian. However, Huang Lian is likely to remove heart fire, and Ku Shen is likely to remove heart fire and small intestine fire, so it is clear in the smell of Huang Lian and turbid in the smell of Ku Shen. It is also indicated that the bitter taste is accompanied by dryness of spleen according to the two characters of Buzhong.

5. Changsha Yao Jie (Changsha Yao Jie solution): for fox being eroded in the lower part, the liver governs tendons, while the anterior yin accumulates in the zongzi, so that wood is soaked in soil and wood is depressed to generate heat, which can generate NI and erode the anterior yin, so that Kuh-seng can clear heat and remove dampness to cure sore and kill parasites. The Dang Gui Bei mu Ku Shen Wan is used for treating difficulty in urination and defecation due to dampness and wood invasion by soil, heat generation due to depression, inability to drain water and heat conduction in bladder, and also for treating stranguria due to dampness and heat clearing of Ku Shen.

6. The book of materia Medica: ku Shen is bitter and cold in nature, has actions of bringing down fever and purging damp-heat, similar to Qin, Lian and Long Dan, but Ku Shen is extremely bitter and dry, so it can kill damp-heat parasites, and is stronger than Qin and Lian. People are afraid of using decoction, and are afraid of bitter taste and serious and evasive. Although this is not the case, people are supposed to wash sores because of the bitter wind, and people are unlikely to eat ears due to dysphagia.

7. Shen nong Ben Cao Jing: it is mainly used for treating heart and abdominal stagnation, abdominal mass accumulation, jaundice, drowning, removing edema, removing carbuncle, strengthening the middle warmer, improving eyesight, and stopping lacrimation.

8. The miscellaneous records of famous physicians: nourishing liver and gallbladder qi, calming five internal organs, tranquilizing mind, replenishing vital essence, benefiting nine orifices, removing latent heat in intestine, quenching thirst, relieving hangover, yellow and red urine, treating malignant boil lower ulcer, calming stomach qi, and being addicted to food.

9. Ceramic carry scene: for those who suffer from scabies and who are drunk in the mouth, they can kill parasites.

10. Treatise on herb Property: for heat-toxin wind, skin and muscle irritability and sores, scabby eyebrows, it is mainly used to remove hot and somnolence, cold and pain in abdomen, nausea and abdominal pain, and to remove body stuffiness and accumulation of heart and abdomen.

11. Tang Ben Cao (materia Medica of Tang Dynasty): it is used for treating tibial acid and malignant insect.

12. Rihuazi Bencao: killing infantile malnutrition insect. Stir-baked with smoke and discharged as powder, and when meal is drunk, it is indicated for intestinal wind and bleeding with dysentery due to heat.

13. Pearl sacs: and (6) dehumidifying.

14. The Yunnan herbal medicine: cool blood, clear heat toxin, scabies and pus-nest sore toxin. Treating skin pruritus, tinea, skin ulcer, obstinate dander, intestinal wind and hematochezia. Dispel wind, remove swelling and toxicity, and remove phlegm-toxicity.

15. The herbal supplement: dry dampness, predominating heat, indicated for seminal emission.

The medicine of the invention is scientifically matched, has strong efficacy, rapid efficacy and stable efficacy, and has the efficacies of clearing away heat and toxic material, removing heat from the blood, promoting blood circulation to remove blood stasis and the like. The medicine has unique treatment effect on senile plaque, and has obvious treatment effect on freckle, chloasma, sunburn, cyasma and pigmented spots of middle-aged and young people. The medicine also has the characteristics of unique formula, small dosage, quick response, obvious curative effect and the like, and the effective rate of treatment is more than 86% through clinical verification.

The following specific examples provided by the inventors further illustrate a traditional Chinese medicine composition for removing senile plaques and a preparation method thereof.

Example 1

A Chinese medicinal composition for removing senile plaque comprises oral medicine and topical medicine; the weight of each raw material medicine in the oral medicine is as follows: 6 parts of radix aconiti kusnezoffii, 2.5 parts of caulis spatholobi, 4 parts of castoreum fruit, 2 parts of ginkgo, 1 part of rehmannia root, 2 parts of astragalus membranaceus and 2 parts of salvia miltiorrhiza; the weight of each raw material medicine in the externally applied medicine is as follows: 6 parts of radix aconiti kusnezoffii, 3 parts of radix tinosporae and 4 parts of radix sophorae flavescentis.

The oral administration pharmaceutical preparation of the invention is orally disintegrating tablets, and the preparation method is as follows: a. mixing 6 parts of radix aconiti kusnezoffii, 2.5 parts of sargentgloryvine stem, 4 parts of castoreum fruit, 2 parts of ginkgo, 1 part of rehmannia root, 2 parts of astragalus root and 2 parts of salvia miltiorrhiza according to a formula, crushing, adding 12-fold volume of water for soaking for 2-3 hours, heating and decocting, and slightly boiling and leaching to obtain decoction liquid and decoction dregs; b. adding 10 times of water to decoct the Chinese medicine residue in the step a for 3 times to obtain 3 times of decoction liquid; c. mixing the decoctions obtained in the steps a and b, settling, filtering, concentrating, and freeze-drying to obtain active components of the oral medicine; d. and c, adding the active components of the oral medicine obtained in the step c into filler mannitol, microcrystalline cellulose, disintegrant low-substituted hydroxypropyl cellulose and sodium carboxymethyl starch to prepare an orally disintegrating tablet, wherein the hardness of the tablet is 1.0 kgf-3.0 kgf.

The topical medicinal preparation is prepared by mixing 6 parts radix Linderae, 3 parts radix tinosporae and 4 parts radix Sophorae Flavescentis, crushing, placing in a container, adding 3 times of 35-45% (v/v) Chinese liquor, sealing, soaking for 5 days, and collecting supernatant.

Example 2

A Chinese medicinal composition for removing senile plaque comprises oral medicine and topical medicine; the oral medicine comprises the following raw material medicines in parts by weight: 4 parts of radix aconiti kusnezoffii, 1.5 parts of caulis spatholobi, 2 parts of castoreum fruit, 1 part of ginkgo, 2 parts of rehmannia root, 1 part of astragalus root and 1.5 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 5 parts of radix aconiti kusnezoffii, 5 parts of radix tinosporae and 3.5 parts of radix sophorae flavescentis.

In this embodiment, the oral pharmaceutical preparation is a large honeyed pill, and the preparation method is as follows: mixing 4 parts of radix aconiti kusnezoffii, 1.5 parts of sargentgloryvine stem, 2 parts of castoreum fruit, 1 part of ginkgo, 2 parts of rehmannia, 1 part of astragalus and 1.5 parts of salvia miltiorrhiza according to a formula, drying, crushing into fine powder, sieving with a 120-mesh sieve, weighing honey according to a weight ratio of 1:5, heating in an evaporation dish to boil, refining the honey, mixing the refined honey with the medicinal powder according to a ratio, and preparing into large honeyed pills.

The externally applied medicine preparation is powder, and the preparation process includes mixing 5 portions of radix aconiti kusnezoffii, 5 portions of tinospora cordifolia and 3.5 portions of radix sophorae flavescentis, crushing, mixing in container, adding mannitol as stuffing and magnesium stearate as lubricant, sieving with 100-mesh 120-mesh sieve to obtain the powder.

Example 3

A Chinese medicinal composition for removing senile plaque comprises oral medicine and topical medicine; the oral medicine comprises the following raw material medicines in parts by weight: 3 parts of radix aconiti kusnezoffii, 3 parts of caulis spatholobi, 2 parts of castoreum fruit, 2 parts of ginkgo, 1 part of rehmannia root, 1 part of astragalus root and 2 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 6 parts of radix aconiti kusnezoffii, 3 parts of radix tinosporae and 4 parts of radix sophorae flavescentis.

Preferably, the oral pharmaceutical preparation is a capsule, and the preparation method is as follows: a. mixing 3 parts of radix aconiti kusnezoffii, 3 parts of caulis spatholobi, 2 parts of castanopsis mollis, 2 parts of ginkgo, 1 part of rehmannia, 1 part of astragalus and 2 parts of salvia miltiorrhiza according to a formula, crushing, adding 12 times of water for soaking for 3 hours, heating and decocting, and slightly boiling and leaching to obtain decoction liquid and decoction dregs; b. adding 12 times of water to decoct the Chinese medicine residue in the step a for 3 times to obtain 3 times of decoction; c. mixing the decoctions obtained in the steps a and b, settling, filtering, concentrating, and freeze-drying to obtain active components of the oral medicine; d. and c, drying and crushing the active components of the oral medicine obtained in the step c, and sieving the crushed active components with a 100-mesh sieve, wherein the active components are as follows by weight: the pharmaceutically acceptable auxiliary materials are 1:0.5, wherein the auxiliary materials are filler, lubricant and adhesive, and are respectively starch, talcum powder and water, and the mixture is prepared into capsules for taking.

The topical medicinal preparation is prepared by mixing 6 parts radix Linderae, 3 parts radix tinosporae and 4 parts radix Sophorae Flavescentis, pulverizing, placing into a container, adding 35-45% (v/v) Chinese liquor 3 times the volume of the container, sealing, soaking for 5 days, and collecting supernatant to be applied to affected part.

Example 4

A Chinese medicinal composition for removing senile plaque comprises oral medicine and topical medicine; the oral medicine comprises the following raw material medicines in parts by weight: 3 parts of radix aconiti kusnezoffii, 1 part of caulis spatholobi, 2 parts of castoreum fruit, 1 part of ginkgo, 1 part of rehmannia root, 1 part of astragalus membranaceus and 2 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 5 parts of radix aconiti kusnezoffii, 3 parts of radix tinosporae and 2 parts of radix sophorae flavescentis.

The preparation method of the oral medicament dosage form is the following steps: a. mixing 3 parts of radix aconiti kusnezoffii, 1 part of caulis spatholobi, 2 parts of castanopsis mollis, 1 part of ginkgo, 1 part of rehmannia glutinosa, 1 part of astragalus membranaceus and 2 parts of salvia miltiorrhiza according to a formula, crushing, adding 10 times of water for soaking for 3 hours, heating and decocting, and slightly boiling and leaching to obtain decoction liquid and decoction dregs; b. adding 10 times of water to decoct the Chinese medicine residue in the step a for 3 times to obtain 3 times of decoction liquid; c. mixing the decoctions obtained in the steps a and b, settling, filtering, concentrating, and freeze-drying to obtain active components of the oral medicine; d. and c, drying and crushing the active components of the oral medicine obtained in the step c, and sieving the crushed active components with a 100-mesh sieve, wherein the active components are as follows by weight: the pharmaceutically acceptable auxiliary materials are 1:0.5, wherein the auxiliary materials are filler, lubricant and adhesive, and are respectively mannitol, magnesium stearate and water, and the mixture is tabletted, and the weight of the tablet is 65 mg/tablet.

The topical preparation is in the form of cream, and is prepared by mixing 5 parts of radix Rubi Corchorifolii Immaturus, 3 parts of radix tinosporae and 2 parts of radix Sophorae Flavescentis, pulverizing, placing in a container, adding 5-20% glycerol as dispersant, and stirring.

Example 5

The oral pharmaceutical compositions are mixed and decocted with water to obtain decoction for administration, and can also be prepared into various oral preparations such as granules, pills, tablets, capsules and the like by using the conventional Chinese medicinal preparation method for administration. Preferably, the oral medicines are mixed, dried and crushed into fine powder according to the proportion, the fine powder is sieved by a 120-mesh sieve, the honey is weighed according to the weight ratio of 1:5, the mixture is heated in an evaporation dish to boil, the refined honey is refined, and the refined honey and the medicinal powder are mixed according to the proportion to prepare large honeyed pills for taking.

The topical part is preferably prepared into medicated liquor, and applied to affected part by mixing the topical medicines, crushing, placing in a suitable container, adding 35-45% (v/v) Chinese liquor, sealing, soaking for 3-5 days, and collecting supernatant; or can be applied to affected part in the form of liquid, cream, powder, etc.

Example 6

The traditional Chinese medicine composition for removing the senile plaques comprises the following raw material medicines in parts by weight in an oral medicine: 3 parts of radix aconiti kusnezoffii, 1 part of caulis spatholobi, 2 parts of castoreum fruit, 1 part of ginkgo, 1 part of rehmannia root, 1 part of astragalus root and 1 part of salvia miltiorrhiza. The preparation method comprises the following steps: weighing the raw materials according to the proportion, mixing, chopping, adding 12 times of water for soaking for 2 hours, heating and decocting until the mixture is slightly boiled, and separating decoction; adding 10 times of water, decocting twice, combining the three decoctions, settling and filtering residues, evaporating and concentrating, freeze-drying, sieving by a 100-mesh sieve, and subpackaging in capsules to obtain the oral administration capsule.

The external application medicine comprises the following raw material medicines in parts by weight: 6 parts of radix aconiti kusnezoffii, 2 parts of radix tinosporae and 2 parts of radix sophorae flavescentis. Mixing the raw materials at a certain proportion, crushing, placing in a suitable container, adding 35-45% (v/v) Chinese liquor, sealing, soaking for 3-5 days to obtain clear liquid, and applying on affected part.

The dosage and the use method of the medicine are as follows: the oral medicine is taken orally on an empty stomach 3 times in the morning, in the middle and at night, and the oral dose is 60-90g per time; the topical medicine is applied to affected part 3-5 times daily for 4 hr, with the application amount being 30-50 g. The medicine is used internally and externally, 7 days are taken as treatment courses, 2-3 treatment courses are generally taken by patients, and 5-7 treatment courses are taken by serious patients.

Proof of drug effect

According to case history, from 1932 to 1978, 110 cases of senile plaques are removed by a secret recipe handed down from the ancestor by an ancestor father (Miao medicine family) of the applicant, wherein 67 cases of the epilogies, 15 cases of the validators, 28 cases of the invalidators and 74% of the total validators are recorded.

The applicant inherits the secret prescription handed down from the ancestors of the seedling from the beginning of the nineties, and 50 cases of senile plaques are removed by using the medicament, wherein 30 cases of the remarkable patients, 13 cases of the effective patients, 7 cases of the ineffective patients and 86 percent of the total effective patients.

Typical cases

Case 1: zhang a certain, man, 69 years old, Shang Ji Zi Bao Wan Cui people in ancient county of Xiangxi state, worked at home. Clinical treatment in 2002, symptoms show: the left and right cheeks, nape and hand back of the eye have uneven spots, large spots higher than the skin and are flat brown pigment. And (3) diagnosis: it belongs to the typical senile plaque. The treatment method is that the medicine for clearing away heat and toxic material, tonifying qi and enriching blood, clearing blood and removing stasis and nourishing and conditioning is taken orally, and the medicine for clearing away heat and toxic material, clearing blood and cooling blood, activating blood and dissolving stasis is taken externally. The medicine can be externally applied and orally taken for 3 treatment courses (seven days are one treatment course).

Case 2: zhang Yi, woman, 53 years old, Yuan Ling county, Huai City. The symptoms are shown as follows: yellow skin, spots on face, forehead, back, neck, chest, back of hand, and hand stick, flat shape, large spots higher than skin, hard touch, large and lumpy cheeks on the left and right sides of the eye, and spots on face. Since the skin is white and thin, a plurality of small black spots are formed on the face of the child after the child grows two births, and the number of the small black spots is increased, so that the small black spots are also formed on the chest of the upper body. And (3) diagnosis: the symptoms belong to senile plaque and chloasma. The treatment method comprises the following steps: the medicine of the invention is orally taken and externally applied, and has the functions of clearing away heat and toxic material, invigorating qi and enriching blood, clearing blood and removing stasis, and externally used for clearing away heat and toxic material, clearing blood and cooling blood, and promoting blood circulation and removing blood stasis. The medicine is externally applied and orally taken for 7 courses of treatment (seven days is one course of treatment).

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and it will be apparent to those skilled in the art that any modifications, equivalents and improvements made within the spirit and principle of the present invention are included in the scope of the present invention.

Claims

1. The traditional Chinese medicine composition for removing the senile plaques is characterized by comprising an oral medicine and an external medicine, wherein the oral medicine comprises the following raw material medicines in parts by weight: 3-6 parts of radix aconiti kusnezoffii, 1-3 parts of caulis spatholobi, 2-4 parts of castoreum fruit, 1-2 parts of ginkgo, 1-2 parts of rehmannia, 1-2 parts of astragalus membranaceus and 1-2 parts of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 5-7 parts of radix aconiti kusnezoffii, 3-5 parts of radix tinosporae and 2-4 parts of radix sophorae flavescentis.

2. The traditional Chinese medicine composition for removing the senile plaques as claimed in claim 1, wherein the oral medicine comprises the following raw materials in parts by weight: 3 parts of radix aconiti kusnezoffii, 1 part of caulis spatholobi, 2 parts of castoreum fruit, 1 part of ginkgo, 1 part of rehmannia root, 1 part of astragalus membranaceus and 1 part of salvia miltiorrhiza; the external application medicine comprises the following raw material medicines in parts by weight: 6 parts of radix aconiti kusnezoffii, 3 parts of radix tinosporae and 2 parts of radix sophorae flavescentis.

3. The traditional Chinese medicine composition for removing the senile plaques as claimed in any one of claims 1 and 2, wherein the oral administration dosage form is pills, granules, tablets or capsules; the dosage form of the external application medicine is aqua, cream, powder or wine.

4. The preparation method of the traditional Chinese medicine composition for removing the senile plaques as claimed in any one of claims 1 and 2, wherein the preparation method of the oral medicine comprises the following steps: a. mixing the oral medicine of radix Linderae, caulis Sargentodoxae, fructus raccoon, semen Ginkgo, rehmanniae radix, radix astragali and Saviae Miltiorrhizae radix according to the formula, pulverizing, adding 10-15 times of water, soaking for 2-3 hr, heating, decocting, and slightly boiling for leaching to obtain decoction and residue; b. adding 10-15 times of water, and decocting the residue in step a for 2-3 times to obtain 2-3 times decoction; c. mixing the decoctions obtained in the steps a and b, settling, filtering, concentrating, and freeze-drying to obtain active components of the oral medicine; d. and c, adding pharmaceutically acceptable auxiliary materials into the active components of the oral medicament obtained in the step c to prepare any pharmaceutically acceptable oral dosage form.

5. The method for preparing the traditional Chinese medicine composition for removing the senile plaques as claimed in claim 4, wherein the active components of the oral medicine obtained in the step c are dried, crushed and sieved by a sieve of 100-120 meshes.

6. The preparation method of the traditional Chinese medicine composition for removing the senile plaques as claimed in any one of claims 1 and 2, wherein the oral medicine is a big honeyed pill, and the preparation method comprises the steps of mixing, drying and crushing the oral medicine of radix linderae, caulis spatholobi, castoreum, ginkgo, rehmannia, astragalus and salvia miltiorrhiza according to a formula into fine powder, sieving the fine powder by a 120-mesh sieve, weighing honey according to a weight ratio of 1:5, heating the honey in an evaporation dish to boil, refining the honey, and mixing the refined honey with the medicine powder according to a ratio to prepare the big honeyed pill.

7. The preparation method of the traditional Chinese medicine composition for removing the senile plaques as claimed in any one of claims 1 and 2, wherein the dosage form of the externally applied medicine is a medicinal liquor, and the preparation method comprises the following steps: mixing the topical medicines including radix Linderae, radix tinosporae and radix Sophorae Flavescentis according to the formula, crushing, placing in a suitable container, adding 2-5 times of 35-45 ° Chinese liquor, sealing, soaking for 3-5 days, and collecting supernatant to be applied to affected part.

8. The preparation method of the traditional Chinese medicine composition for removing the senile plaques as claimed in any one of claims 1 and 2, wherein the external application medicine is in the form of powder, and the preparation method comprises the following steps: mixing the externally applied medicines of radix aconiti kusnezoffii, radix tinosporae and radix sophorae flavescentis according to a formula, crushing, putting into a container, adding pharmaceutically acceptable auxiliary materials of a filler and a lubricant, fully mixing, and sieving by a sieve of 100 meshes and 120 meshes to obtain powder.