CN102512644A - Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same - Google Patents
Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same Download PDFInfo
- Publication number
- CN102512644A CN102512644A CN2011104233257A CN201110423325A CN102512644A CN 102512644 A CN102512644 A CN 102512644A CN 2011104233257 A CN2011104233257 A CN 2011104233257A CN 201110423325 A CN201110423325 A CN 201110423325A CN 102512644 A CN102512644 A CN 102512644A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for removing freckles and nourishing skin and a preparation method for the same, wherein the traditional Chinese medicine composition contains traditional Chinese medicines in the following parts by weight: 10-100 parts of radix bupleuri, 10-100 parts of bighead atractylodes rhizome, 10-100 parts of ginger, 10-100 parts of salvia miltiorrhiza, 10-100 parts of peach kernels, 10-100 parts of artemisia apiacea, 10-100 parts of ligusticum wallichii, 20-80 parts of angelica sinensis, 20-80 parts of radix paeoniae alba, 20-80 parts of fried gardenias, 20-80 parts of rhizoma cyperi, 10-70 parts of moutan bark, 10-70 parts of mint and 1-10 parts of saffron crocus. The traditional Chinese medicine composition provided by the invention can be used for treating facial chloasma and chromatosis.
Description
Technical field
The present invention relates to medical invention field, be specifically related to Chinese medicine composition of a kind of spot-removing beautifying face and preparation method thereof.
Background technology
(Chloasma Melasma) is also referred to as chloasma hepaticum to chloasma, is a kind of of facial melanosis, is the pigmentation spots that occurs in face.
Chloasma is also referred to as chloasma hepaticum and butterfly spot, is a kind of symptom of facial melanosis, is the pigmentation spots that occurs in face.The reason that chloasma forms mainly is that stress is big because of the female incretion imbalance, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.
Mainly because of the female incretion imbalance, stress is big for chloasma, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.For the chloasma of skin, mainly in line with prevention and the bonded method of treatment.Conditioned female incretion environment keeps happy, and active prevention gynaecopathia etc. is the effective means of prevention chloasma.The treatment chloasma is divided into methods such as food accent, medication, naturopathy, but effective method is that laser is nursed one's health with Chinese Medicine and Clavicular.
Traditional Chinese medical science research draws, and is reflected in the fleckiness on the skin, all with internal organs necessary relation is arranged.The essence of five ZANG-organs and six FU-organs gas is full, the then delicate gloss of skin; The essence of five ZANG-organs and six FU-organs gas is deficient, and skin is then dispirited withered and yellow." speckle " comes down to vital organs of the human body dysfunction, disharmony between QI and blood, and stagnation of QI due to depression of the liver, qi depression to blood stasis, qi-blood-body fluid circulation freely do not reach the reflection of endocrine disturbance at face.Control speckle and answer treating both the principal and secondary aspects of a disease, the conditioning of traditional Chinese medical science draft speckle dispelling is controlled from the five internal organs opinion, through regulating qi-blood-body fluid in the hope of Yin Yang balancing, reaches the purpose of spot-removing beautifying face, can obtain to stop chloasma to recur.
One Chinese patent application 99124907.0 discloses the compound recipe of being made up of Herba Artemisiae Annuae, Borneolum Syntheticum, three kinds of Chinese medicines of Stigma Croci, is used to treat laryngopharyngeal diseases.
One Chinese patent application 201010194124.X discloses a kind of nursing face health wine; This nursing face health wine takes by weighing following raw materials according by weight: the pure grain Chinese wine 1500 of Radix Angelicae Sinensis 9-11, Rhizoma Chuanxiong 4-6, Radix Paeoniae Alba 9-11, Radix Rehmanniae Preparata 9-11, Radix Polygoni Multiflori 9-11, Radix Salviae Miltiorrhizae 9-11, Radix Astragali 19-21, Radix Codonopsis 9-11, Rhizoma Atractylodis Macrocephalae 9-11, Fructus Jujubae 9-11, Fructus Lycii 9-11, Fructus Corni 5-7, Radix Bupleuri 5-7, Flos Carthami 5-7, Rhizoma Cyperi 5-7, Radix Achyranthis Bidentatae 5-7, Herba Leonuri 5-7, Radix Angelicae Dahuricae 5-7,50 degree; With the raw material chopping, put into container, in container, add the pure grain Chinese wine of 50 degree again; Container is put into the cellar; Seal after 80-90 days, filter, the packing of gained filtrating gets final product.Wine has dissolved above-mentioned Chinese medicine as solvent, makes effective ingredient discharge, but Chinese liquor is not suitable for the irritated or responsive crowd of ethanol for ethanol.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of spot-removing beautifying face.
Another object of the present invention provides a kind of method for preparing of Chinese medicine composition.
The invention provides a kind of Chinese medicine composition of spot-removing beautifying face, contain following parts by weight of Chinese traditional medicine: Radix Bupleuri 10-100 part, Rhizoma Atractylodis Macrocephalae 10-100 part, Rhizoma Zingiberis Recens 10-100 part, Radix Salviae Miltiorrhizae 10-100 part, Semen Persicae 10-100 part, Herba Artemisiae Annuae 10-100 part, Rhizoma Chuanxiong 10-100 part, Radix Angelicae Sinensis 20-80 part, Radix Paeoniae Alba 20-80 part, Fructus Gardeniae (parched) 20-80 part, Rhizoma Cyperi 20-80 part, Cortex Moutan 10-70 part, Herba Menthae 10-70 part, Stigma Croci 1-10 part.
Preferably; The Chinese medicine composition of spot-removing beautifying face provided by the invention contains following parts by weight of Chinese traditional medicine: Radix Bupleuri 40-80 part, Rhizoma Atractylodis Macrocephalae 40-80 part, Rhizoma Zingiberis Recens 40-80 part, Radix Salviae Miltiorrhizae 40-80 part, Semen Persicae 40-80 part, Herba Artemisiae Annuae 40-80 part, Rhizoma Chuanxiong 40-80 part, Radix Angelicae Sinensis 30-70 part, Radix Paeoniae Alba 30-70 part, Fructus Gardeniae (parched) 30-70 part, Rhizoma Cyperi 30-70 part, Cortex Moutan 20-60 part, Herba Menthae 20-60 part, Stigma Croci 3-7 part.
Further preferably; The Chinese medicine composition of spot-removing beautifying face provided by the invention contains following parts by weight of Chinese traditional medicine: 60 parts of Radix Bupleuri, 60 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts in Rhizoma Zingiberis Recens, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts in Semen Persicae, 60 parts of Herba Artemisiae Annuaes, 60 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 50 parts of the Radix Paeoniae Albas, 50 parts of Fructus Gardeniae (parched), 50 parts of Rhizoma Cyperis, 40 parts of Cortex Moutans, 40 parts of Herba Menthaes, 5 parts of Stigma Crocis.
Said Radix Bupleuri is preferably Radix Bupleuri (processed with vinegar); The Rhizoma Atractylodis Macrocephalae is preferably Rhizoma Atractylodis Macrocephalae (parched with bran); Radix Salviae Miltiorrhizae is preferably Radix Salviae Miltiorrhizae; Radix Angelicae Sinensis is preferably Radix Angelicae Sinensis (steamed); The Radix Paeoniae Alba is preferably Radix Paeoniae Alba (processed with wine).
The present invention also provides the method for preparing above-mentioned Chinese medicine composition, and this method may further comprise the steps:
1) Stigma Croci extracted 0.5-3 hour with ethanol extraction 2-5 time at every turn, filter, and merging filtrate, filtrate recycling ethanol also is concentrated into the concentrated solution that relative density is 1.05 (30 ℃), and is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross the 40-200 mesh sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2-5 time, decocting time is 0.5-3 hour; Collecting decoction; Be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make it contain alcohol amount to reach 60%, left standstill 12-36 hour; Filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 60-85 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing promptly gets.
In the said method:
Said concentration of ethanol is 30-80%, and consumption is that the 1-5 of croceous weight doubly measures;
When decocting boils in the said step 3), the consumption of water be medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan weight 1-5 doubly.
Chinese medicine composition provided by the invention can directly be prepared into various dosage forms, also can be prepared into various dosage forms with pharmaceutically acceptable carrier combinations.
Said dosage form is sheet, hard capsule, granule, granule, soft capsule or pill.
Said pharmaceutically acceptable carrier or diluent are meant the pharmaceutical carrier that pharmaceutical field is conventional, are selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
Said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Said binding agent is selected from cellulose derivative, alginate, ethanol, gelatin or polyvinylpyrrolidone etc.;
Said disintegrating agent is selected from microcrystalline Cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Said lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate;
Said suspending agent is selected from micropowder silica gel, Cera Flava, cellulose, solid polyethylene glycol;
Said wetting agent is selected from glycerol, tween 80, ethyoxyl castor oil hydrogenated or lecithin;
Said solvent is selected from ethanol, liquid polyethylene glycol, isopropyl alcohol, glycerol, propylene glycol or vegetable oil, and said vegetable oil is selected from soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods;
Said surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, polyoxyethylene-polyoxypropylene copolymer, the fatty acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.;
Said sweeting agent is selected from aspartame, Sucralose, essence, citric acid or saccharin sodium.
The present invention also provides above-mentioned Chinese medicine composition and its preparation to treat chloasma faciei, the health product of pigment or the application on the medicine in preparation.
Not provided by the invention not being taken by pregnant women.
Chinese medicine composition provided by the invention has the following advantages:
1, in the medicine of the present invention:
Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..Radix Bupleuri (processed with vinegar) is hot, bitter, is slightly cold.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for cold, fever, alternate attack of chill and fever, sternal rib pain, menoxenia, uterine prolapse, proctoptosis.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Rhizoma Atractylodis Macrocephalae (parched with bran) bitter in the mouth, sweet, warm.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Rhizoma Zingiberis Recens is the fresh rhizome of zingiber Zingiber officinale Rosc..Acrid in the mouth, tepor.Return lung, spleen, stomach warp.The cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.Be used for anemofrigid cold, gastrofrigid vomiting, the cold-phlegm cough, the fish Eriocheir sinensis poisons.
Radix Salviae Miltiorrhizae is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Bitter in the mouth is slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle.Be used for obstruction of qi in the chest and cardialgia, gastral cavity abdominal rib Tong ， lumps in the chest and abdomen, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, the dysmenorrhea amenorrhea, skin infection swells and ache.
Semen Persicae is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunusdavidiana (Carr.) Franch. dry mature seed.Bitter in the mouth, sweet is flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea dysmenorrhea ， mass in the abdomen mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae annuae Artemisia annua L..Bitter in the mouth, suffering, cold.Return liver, gallbladder meridian.Clearind deficient heat is removed hectic fever due to YIN-deficiency, separates summer-heat, cut cruel, jaundice eliminating.Be used for the pathogenic warmth impairment of YIN, night fever abating at dawn, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, pathogenic summer-heat heating, malaria cold and heat, jaundice due to damp-heat.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Acrid in the mouth, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for obstruction of qi in the chest and cardialgia, costa sternales twinge, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, headache, rheumatic arthralgia.
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Sweet in the mouth, suffering, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Bitter in the mouth, acid is slightly cold.Return liver, spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Be used for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, costalgia, stomachache, limb pain twin, it is dizzy to have a headache.
Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.Bitter in the mouth, cold.GUIXIN, lung, tri-jiao channel.The pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The externally used detumescence pain relieving.It is vexed to be used for calentura, jaundice due to damp-heat, and the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Acrid in the mouth, little hardship, little sweet, flat.Return liver, spleen, tri-jiao channel.Dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, sternal rib pain, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
Cortex Moutan is the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Bitter in the mouth, suffering are slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Be used for heat and go into nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, the amenorrhea dysmenorrhea is fallen and is pounced on the pain of injury, too fat to move sore.
Herba Menthae is the dry aerial parts of labiate Mentha haplocalyx Briq..Acrid in the mouth, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, the headache, conjunctival congestion, sore throat, aphtha, rubella, measles, costa sternales feeling of distension and oppression.
Stigma Croci is the dry stigma of irides Stigma Croci Crocus sativus L..Sweet in the mouth is flat.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Play liver-smoothing, qi-regulating, constraint eliminating and menstruation regulating, invigorate blood circulation full side, the effect of blood stasis dispelling, speckle dispelling, is applicable to chloasma faciei, pigmentation.
2, through clinical experience for many years, finally confirmed the present invention, experimental result shows: Chinese medicine composition provided by the invention has treatment chloasma faciei, Pigmented effect, and effect is superior to prior art.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 60g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 60g, Rhizoma Zingiberis Recens 60g, Radix Salviae Miltiorrhizae 60g, Semen Persicae 60g, Herba Artemisiae Annuae 60g, Rhizoma Chuanxiong 60g, Radix Angelicae Sinensis (steaming) 50g, the Radix Paeoniae Alba (wine is processed) 50g, Fructus Gardeniae (parched) 50g, Rhizoma Cyperi 50g, Cortex Moutan 40g, Herba Menthae 40g, Stigma Croci 5g.
2, method for preparing:
1) Stigma Croci adds 50% ethanol of 2 times of amounts of Stigma Croci weight with extracting 2 times at every turn, and extraction time is: 1 hour for the first time, and 0.5 hour for the second time, filter, it is the concentrated solution of 1.05 (30 ℃) that merging filtrate, filtrate recycling ethanol are concentrated into to relative density, subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross 40 mesh sieves, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 3 times adds 2 times water of nine highly seasoned amounts such as medicinal residues and all the other Radix Bupleuri at every turn; Extracted 2 hours for the first time, extracted 1 hour for the second time, extracted for the third time 1 hour; Collecting decoction is concentrated into relative density 1.05 (30 ℃), adds ethanol and makes content reach 60%; Left standstill 24 hours, and filtered, be condensed into the thick paste of relative density 1.30 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and processes 1000, promptly gets.
Embodiment 2: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 80g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 40g, Rhizoma Zingiberis Recens 80g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 40g, Herba Artemisiae Annuae 40g, Rhizoma Chuanxiong 40g, Radix Angelicae Sinensis (steaming) 70g, the Radix Paeoniae Alba (wine is processed) 30g, Fructus Gardeniae (parched) 30g, Rhizoma Cyperi 50g, Cortex Moutan 60g, Herba Menthae 20g, Stigma Croci 5g.
2, method for preparing:
1) Stigma Croci adds 2 times 60% ethanol of Stigma Croci weight with ethanol extraction 3 times at every turn, and extraction time is: 1 hour for the first time, and 0.5 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2 times adds 3 times water of nine highly seasoned amounts such as medicinal residues and all the other Radix Bupleuri at every turn; Extraction time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction; Be concentrated into relative density 1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 12 hours; Filter, be condensed into the thick paste of relative density 1.30 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, adds the starch of 20g, and mixing incapsulates, and processes 1000, promptly gets.
Embodiment 3: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 40g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 80g, Rhizoma Zingiberis Recens 40g, Radix Salviae Miltiorrhizae 40g, Semen Persicae 80g, Herba Artemisiae Annuae 80g, Rhizoma Chuanxiong 60g, Radix Angelicae Sinensis (steaming) 30g, the Radix Paeoniae Alba (wine is processed) 50g, Fructus Gardeniae (parched) 70g, Rhizoma Cyperi 60g, Cortex Moutan 50g, Herba Menthae 50g, Stigma Croci 5g.
2, method for preparing:
1) Stigma Croci is with ethanol extraction 3 times, adds 3 times of Stigma Croci weight 60% ethanol at every turn, and extraction time is: 1.5 hours for the first time, and 1 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2 times adds 3 times water of medicinal residues and all the other nine flavor medicine weight at every turn; Decocting time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction; Be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 36 hours; Filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and processes 1000, promptly gets.
Embodiment 4: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 20g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 100g, Rhizoma Zingiberis Recens 80g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 100g, Herba Artemisiae Annuae 50g, Rhizoma Chuanxiong 50g, Radix Angelicae Sinensis (steaming) 30g, the Radix Paeoniae Alba (wine is processed) 10g, Fructus Gardeniae (parched) 80g, Rhizoma Cyperi 70g, Cortex Moutan 40g, Herba Menthae 10g, Stigma Croci 5g.
2, method for preparing:
1) Stigma Croci is with ethanol extraction 3 times, adds 5 times of Stigma Croci weight 30% ethanol at every turn, and 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2 times adds 3 times water of medicinal residues and all the other nine flavor medicine weight; 2 hours for the first time, 1 hour for the second time, collecting decoction; Be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours; Filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃; Be ground into fine powder, sieve, volatile oil sprays into dissolve with ethanol, adds microcrystalline Cellulose, the 5g starch of 10g again; Mixing incapsulates, and processes 1000, promptly gets.
Embodiment 5: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 100g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 20g, Rhizoma Zingiberis Recens 40g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 30g, Herba Artemisiae Annuae 100g, Rhizoma Chuanxiong 20g, Radix Angelicae Sinensis (steaming) 80g, the Radix Paeoniae Alba (wine is processed) 80g, Fructus Gardeniae (parched) 30g, Rhizoma Cyperi 50g, Cortex Moutan 60g, Herba Menthae 20g, Stigma Croci 5g.
2, method for preparing:
1) Stigma Croci is with ethanol extraction 3 times, adds 65% ethanol of 3 times of amounts of Stigma Croci weight at every turn, and decocting time is: 1 hour for the first time, and 1 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2 times, amount of water is medicinal residues and all the other nine flavor medicine weight 2 times; Decocting time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction; Be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours; Filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and processes 1000, promptly gets.
Embodiment 6: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 50g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 50g, Rhizoma Zingiberis Recens 50g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 50g, Herba Artemisiae Annuae 50g, Rhizoma Chuanxiong 50g, Radix Angelicae Sinensis (steaming) 40g, the Radix Paeoniae Alba (wine is processed) 40g, Fructus Gardeniae (parched) 40g, Rhizoma Cyperi 30g, Cortex Moutan 30g, Herba Menthae 30g, Stigma Croci 3g.
2, method for preparing:
1) Stigma Croci is with 70% ethanol extraction 3 times, adds alcoholic acid amount three times to be respectively 3 times, 1.5 times, 1.5 times, and decocting time is: 1 hour for the first time; 0.5 hour for the second time, 0.5 hour for the second time, filter; Merging filtrate, filtrate recycling ethanol also is concentrated in right amount, and concentrated solution is subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2 times, amount of water is medicinal residues and all the other nine flavor medicine weight 2 times; Decocting time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction; Be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours; Filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃).The Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and processes 1000, promptly gets.
Experimental example: effect experiment
1, experimental data
128 routine patients are the women, age 24-52 year, 27-37 year 92 examples (72%), course of disease 0.5-12, butterfly 86 examples in the majority (67%), other 3 type, 42 examples (23%).
2, clinical diagnosis standard: according to Dermatology Professional Committee of CAIM pigment group " clinical diagnosis of chloasma and curative effect " diagnosis and typing.
3, Therapeutic Method:
According to pill taker voluntarily and on request, divide treatment by Chinese herbs group and western medicine group.Chinese drug-treated group 73 examples wherein, Western medicine group 55 examples.Poor different no significances such as two groups of patient's Clinical typings, age, the course of disease, wherein:
Chinese drug-treated group: take spot removing and face nursing capsule (product of embodiments of the invention 1 preparation, called after spot removing and face nursing capsule), oral, each 1.6g, every day 3 times.(2) Western medicine group: VITAMIN C TABLET, 0.2g, 3 times/day, oral, vitamin E drop pill 0.1g, 3 times/day are oral.Without other drug, 1 month course of treatment, treat 3 post-evaluation course of treatment curative effects during two groups of treatments.
4, observational technique:
Observe and treat onset time: point system, standard and the equal reference literature of scoring decline index note point methods.Per 2 all further consultation record pigment situations of change.Compare two groups of curative effects and healing time.
The judgement of clinical efficacy:
Basic cure disappear for naked eyes visual pigment speckle area＞90%, color disappears basically, decline index >=0.5 of marking;
Progressive color is thin out for the pigmented spots area disappears 30%, scoring decline index >=0.3.Invalidly disappear for naked eyes visual pigment speckle area＜30%;
Effectively add produce effects note point with basic healing.
5, result: see table 1
Table 1
| Case load | The basic healing | Produce effects | Progressive | Invalid | Total effective rate | |
| Chinese drug-treated group | 73 | 26 examples (35.6%) | 31 examples (42.5%) | 15 examples (20.5%) | 1 example (1.4%) | 78.1％ |
| Western medicine group | 55 | 8 examples (14.5%) | 15 examples (27.3%) | 29 examples (52.7%) | 3 examples (5.5%) | Total effective rate 41.8% |
Can find out from table 1 result: embodiment 1 effect provided by the invention is superior to Western medicine group.
Two groups of healing times: Chinese medicine spot removing and face nursing capsule group 68 ± 13 days, Western medicine group 76 ± 11 days, two groups of comparing differences have significance.
Equally, all the other embodiment and all the other proportionings of the present invention are experimentized, effect and embodiment 1 are similar.
6, conclusion: Chinese medicine composition provided by the invention has treatment chloasma faciei, Pigmented effect, and effect is superior to prior art.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. the Chinese medicine composition of a spot-removing beautifying face; It is characterized in that this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: Radix Bupleuri 10-100 part, Rhizoma Atractylodis Macrocephalae 10-100 part, Rhizoma Zingiberis Recens 10-100 part, Radix Salviae Miltiorrhizae 10-100 part, Semen Persicae 10-100 part, Herba Artemisiae Annuae 10-100 part, Rhizoma Chuanxiong 10-100 part, Radix Angelicae Sinensis 20-80 part, Radix Paeoniae Alba 20-80 part, Fructus Gardeniae (parched) 20-80 part, Rhizoma Cyperi 20-80 part, Cortex Moutan 10-70 part, Herba Menthae 10-70 part, Stigma Croci 1-10 part.
2. Chinese medicine composition according to claim 1; It is characterized in that this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: Radix Bupleuri 40-80 part, Rhizoma Atractylodis Macrocephalae 40-80 part, Rhizoma Zingiberis Recens 40-80 part, Radix Salviae Miltiorrhizae 40-80 part, Semen Persicae 40-80 part, Herba Artemisiae Annuae 40-80 part, Rhizoma Chuanxiong 40-80 part, Radix Angelicae Sinensis 30-70 part, Radix Paeoniae Alba 30-70 part, Fructus Gardeniae (parched) 30-70 part, Rhizoma Cyperi 30-70 part, Cortex Moutan 20-60 part, Herba Menthae 20-60 part, Stigma Croci 3-7 part.
3. Chinese medicine composition according to claim 1; It is characterized in that this Chinese medicine composition contains following parts by weight of Chinese traditional medicine: 60 parts of Radix Bupleuri, 60 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts in Rhizoma Zingiberis Recens, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts in Semen Persicae, 60 parts of Herba Artemisiae Annuaes, 60 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 50 parts of the Radix Paeoniae Albas, 50 parts of Fructus Gardeniae (parched), 50 parts of Rhizoma Cyperis, 40 parts of Cortex Moutans, 40 parts of Herba Menthaes, 5 parts of Stigma Crocis.
4. according to each described Chinese medicine composition of claim 1-3, it is characterized in that said Radix Bupleuri is Radix Bupleuri (processed with vinegar); The Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched with bran); Radix Salviae Miltiorrhizae is a Radix Salviae Miltiorrhizae; When being classified as Radix Angelicae Sinensis (steamed); The Radix Paeoniae Alba is a Radix Paeoniae Alba (processed with wine).
5. method for preparing each said Chinese medicine composition of claim 1-4, this method may further comprise the steps:
1) Stigma Croci extracted 0.5-3 hour with ethanol extraction 2-5 time at every turn, filter, merging filtrate, filtrate recycling ethanol and when being concentrated into 30 ℃ relative density be 1.05 concentrated solution, subsequent use;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be subsequent use;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decocte with water 2-5 time, decocting time is 0.5-3 hour; Collecting decoction; Relative density 1.05-1.10 when being concentrated into 30 ℃ adds ethanol and makes it contain alcohol amount to reach 60%, left standstill 12-36 hour; Filter, relative density is the thick paste of 1.30-1.40 when being condensed into 50 ℃;
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 60-85 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing promptly gets.
6. method according to claim 5 is characterized in that, said concentration of ethanol is 30-80%, and consumption is 1-5 a times of Stigma Croci weight; When decocting boils in the said step 3), the consumption of water be medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan weight 1-5 doubly.
7. contain the preparation that right requires each said Chinese medicine composition of 1-4, said preparation is made up of this Chinese medicine composition and pharmaceutically acceptable carrier or diluent.
8. preparation according to claim 7 is characterized in that, said preparation is sheet, hard capsule, granule, granule, soft capsule, oral liquid or pill.
9. preparation according to claim 7; It is characterized in that; Said pharmaceutically acceptable carrier or diluent are meant the pharmaceutical carrier that pharmaceutical field is conventional, are selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
10. each described Chinese medicine composition of claim 1-4 or each described preparation of claim 7-9 application in preparation treatment chloasma faciei, Pigmented health product and medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110423325 CN102512644B (en) | 2011-12-16 | 2011-12-16 | Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110423325 CN102512644B (en) | 2011-12-16 | 2011-12-16 | Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102512644A true CN102512644A (en) | 2012-06-27 |
| CN102512644B CN102512644B (en) | 2013-08-28 |
Family
ID=46283896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110423325 Active CN102512644B (en) | 2011-12-16 | 2011-12-16 | Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102512644B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830446A (en) * | 2012-11-22 | 2014-06-04 | 师秀玉 | Traditional Chinese medicine for treating endocrine dyscrasia |
| CN104474331A (en) * | 2014-11-29 | 2015-04-01 | 柯利佳 | Preparation method of medicine for treating facial pigmentation |
| CN104587129A (en) * | 2015-02-05 | 2015-05-06 | 济南市儿童医院 | Traditional Chinese medicinal preparation for treating chloasma and preparation method of traditional Chinese medicinal preparation |
| CN106237282A (en) * | 2016-08-25 | 2016-12-21 | 刘根喜 | A kind of replenishing and activating blood, the medicated wine and preparation method thereof of dredging collateral skin care |
| CN108186846A (en) * | 2018-03-23 | 2018-06-22 | 翟启超 | A kind of Chinese medicine composition for treating chloasma and preparation method thereof |
-
2011
- 2011-12-16 CN CN 201110423325 patent/CN102512644B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 付丹丹等: "黄褐斑的中医药治疗概况 ", 《河南中医》 * |
| 付丹丹等: "黄褐斑的中医药治疗概况", 《河南中医》, vol. 25, no. 05, 10 May 2005 (2005-05-10), pages 83 - 86 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830446A (en) * | 2012-11-22 | 2014-06-04 | 师秀玉 | Traditional Chinese medicine for treating endocrine dyscrasia |
| CN104474331A (en) * | 2014-11-29 | 2015-04-01 | 柯利佳 | Preparation method of medicine for treating facial pigmentation |
| CN104587129A (en) * | 2015-02-05 | 2015-05-06 | 济南市儿童医院 | Traditional Chinese medicinal preparation for treating chloasma and preparation method of traditional Chinese medicinal preparation |
| CN104587129B (en) * | 2015-02-05 | 2017-12-29 | 济南市儿童医院 | A kind of Chinese medicine preparation for treating chloasma and preparation method thereof |
| CN106237282A (en) * | 2016-08-25 | 2016-12-21 | 刘根喜 | A kind of replenishing and activating blood, the medicated wine and preparation method thereof of dredging collateral skin care |
| CN108186846A (en) * | 2018-03-23 | 2018-06-22 | 翟启超 | A kind of Chinese medicine composition for treating chloasma and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102512644B (en) | 2013-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488850B (en) | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof | |
| CN102000175B (en) | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof | |
| CN105477616A (en) | Medicine for easing mental anxiety, reducing phlegm, restoring consciousness and promoting blood circulation to remove meridian obstruction and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN102512644B (en) | Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same | |
| CN103055239B (en) | Traditional Chinese medicine for beautifying face and removing freckles and preparation method thereof | |
| CN103432559B (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN103055285A (en) | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof | |
| CN104825612A (en) | Medicine composition for treating gastritis and method for manufacturing medicine composition | |
| CN102512649A (en) | Composition of Chinese medicinal herbs for treating postpartum blood stasis and preparation method thereof | |
| CN104906507A (en) | Traditional Chinese medicine combination for lowering blood pressure and toning physical fitness | |
| CN103690869B (en) | Chinese medicine for the treatment of irritable bowel syndrome and preparation method thereof | |
| CN112870286A (en) | Traditional Chinese medicine composition for treating atopic dermatitis, preparation method and application thereof | |
| CN105521332A (en) | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof | |
| CN104840773A (en) | Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same | |
| CN111388625A (en) | Traditional Chinese medicine composition for regulating and treating blood stasis constitution and preparation and application thereof | |
| CN104324332A (en) | Traditional Chinese medicine preparation for treating liver-qi stagnation type chloasma and production method of traditional Chinese medicine preparation | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN103751582A (en) | Pharmaceutical composition for treating infantile night sweats and preparation method of pharmaceutical composition | |
| CN102988890A (en) | Pure Chinese medicine preparation for treating chloasma | |
| CN115737771B (en) | Traditional Chinese medicine composition for treating liver qi stagnation type oviduct obstruction | |
| CN103417836B (en) | Chinese medicine composition for the treatment of tumor and preparation method thereof | |
| CN105796927A (en) | Traditional Chinese medicine composition for treating blepharospasm | |
| CN103393973B (en) | Chinese medicinal composition for treating rhinitis | |
| CN105343688A (en) | Medicine composition for treating myocardial infarction and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YUNNAN KANGCHUANG BIO-MEDICINE TECHNOLOGY INCUBATI Free format text: FORMER OWNER: GELIKANG BIOLOGICAL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD., QUJING ECONOMI Effective date: 20150212 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150212 Address after: 655000 No. 51 West Swiss Road, Qilin District, Yunnan, Qujing Patentee after: YUNNAN KANGCHUANG BIOPHARMACEUTICAL TECHNOLOGY INCUBATION CO., LTD. Address before: 655000 No. 1 Garden Road, Qujing, Yunnan, Qujing Patentee before: Gelikang Biological Science and Technology Development Co., Ltd., Qujing Economi |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211026 Address after: 655000 No.1 Yuanyuan Road, Qilin District, Qujing City, Yunnan Province Patentee after: QUJING NO.1 PEOPLE'S Hospital Address before: 655000 No. 51, Ruihe West Road, Qilin District, Qujing City, Yunnan Province Patentee before: YUNNAN KANGCHUANG BIOLOGICAL MEDICAL TECHNOLOGY HATCHING Co.,Ltd. |