CN102512644B - Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same - Google Patents
Traditional Chinese medicine composition for removing freckles and nourishing skin and preparation method for same Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for removing freckles and nourishing skin and a preparation method for the same, wherein the traditional Chinese medicine composition contains traditional Chinese medicines in the following parts by weight: 10-100 parts of radix bupleuri, 10-100 parts of bighead atractylodes rhizome, 10-100 parts of ginger, 10-100 parts of salvia miltiorrhiza, 10-100 parts of peach kernels, 10-100 parts of artemisia apiacea, 10-100 parts of ligusticum wallichii, 20-80 parts of angelica sinensis, 20-80 parts of radix paeoniae alba, 20-80 parts of fried gardenias, 20-80 parts of rhizoma cyperi, 10-70 parts of moutan bark, 10-70 parts of mint and 1-10 parts of saffron crocus. The traditional Chinese medicine composition provided by the invention can be used for treating facial chloasma and chromatosis.
Description
Technical field
The present invention relates to medical invention field, be specifically related to Chinese medicine composition of a kind of spot-removing beautifying face and preparation method thereof.
Background technology
(Chloasma Melasma) is also referred to as chloasma hepaticum to chloasma, is a kind of of facial melanosis, is the pigmentation spots that occurs in face.
Chloasma is also referred to as chloasma hepaticum and butterfly spot, is a kind of symptom of facial melanosis, is the pigmentation spots that occurs in face.The reason that chloasma forms mainly is that stress is big because of the female incretion imbalance, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.
Mainly because of the female incretion imbalance, stress is big for chloasma, lacks the stimulation of vitamin and external chemicals in various diseases (hepatic and kidney function obstacle, gynaecopathia, diabetes) etc. and the body and causes.For the chloasma of skin, mainly in line with the method for prevention with the treatment combination.Conditioned female incretion environment keeps happy, and active prevention gynaecopathia etc. is the effective means of prevention chloasma.The treatment chloasma is divided into methods such as food accent, medication, naturopathy, but effective method is laser and Chinese Medicine and Clavicular conditioning.
Traditional Chinese medical science research draws, and is reflected in the fleckiness on the skin, all with internal organs necessary relation is arranged.The essence of five ZANG-organs and six FU-organs gas is full, and skin is delicate gloss then; The essence of five ZANG-organs and six FU-organs gas scarcity, skin are then dispirited withered and yellow." speckle " comes down to vital organs of the human body dysfunction, disharmony between QI and blood, and stagnation of QI due to depression of the liver, qi depression to blood stasis, qi-blood-body fluid circulation freely do not reach the endocrine disturbance in the reflection of face.Control speckle and answer treating both the principal and secondary aspects of a disease, the conditioning of traditional Chinese medical science draft speckle dispelling is controlled from the five internal organs opinion, by regulating qi-blood-body fluid in the hope of Yin Yang balancing, reaches the purpose of spot-removing beautifying face, can obtain to stop chloasma to recur.
Chinese patent application 99124907.0 discloses the compound recipe of being made up of Herba Artemisiae Annuae, Borneolum Syntheticum, three kinds of Chinese medicines of Stigma Croci, is used for the treatment of laryngopharyngeal diseases.
Chinese patent application 201010194124.X discloses a kind of nursing face health wine, this nursing face health wine takes by weighing following raw materials according by weight: Radix Angelicae Sinensis 9-11, Rhizoma Chuanxiong 4-6, Radix Paeoniae Alba 9-11, Radix Rehmanniae Preparata 9-11, Radix Polygoni Multiflori 9-11, Radix Salviae Miltiorrhizae 9-11, Radix Astragali 19-21, Radix Codonopsis 9-11, Rhizoma Atractylodis Macrocephalae 9-11, Fructus Jujubae 9-11, Fructus Lycii 9-11, Fructus Corni 5-7, Radix Bupleuri 5-7, Flos Carthami 5-7, Rhizoma Cyperi 5-7, Radix Achyranthis Bidentatae 5-7, Herba Leonuri 5-7, Radix Angelicae Dahuricae 5-7, the pure grain Chinese wine 1500 of 50 degree, raw material is shredded, put into container, in container, add 50 pure grain Chinese wine of spending again, container is put into the cellar, seal after 80-90 days, filter, the packing of gained filtrate gets final product.Wine has dissolved above-mentioned Chinese medicine as solvent, makes effective ingredient discharge, but Chinese liquor is not suitable for for ethanol allergy or the responsive crowd of ethanol.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of spot-removing beautifying face.
Another object of the present invention provides a kind of preparation method of Chinese medicine composition.
The invention provides a kind of Chinese medicine composition of spot-removing beautifying face, contain following parts by weight of Chinese traditional medicine: Radix Bupleuri 10-100 part, Rhizoma Atractylodis Macrocephalae 10-100 part, Rhizoma Zingiberis Recens 10-100 part, Radix Salviae Miltiorrhizae 10-100 part, Semen Persicae 10-100 part, Herba Artemisiae Annuae 10-100 part, Rhizoma Chuanxiong 10-100 part, Radix Angelicae Sinensis 20-80 part, Radix Paeoniae Alba 20-80 part, Fructus Gardeniae (parched) 20-80 part, Rhizoma Cyperi 20-80 part, Cortex Moutan 10-70 part, Herba Menthae 10-70 part, Stigma Croci 1-10 part.
Preferably, the Chinese medicine composition of spot-removing beautifying face provided by the invention contains following parts by weight of Chinese traditional medicine: Radix Bupleuri 40-80 part, Rhizoma Atractylodis Macrocephalae 40-80 part, Rhizoma Zingiberis Recens 40-80 part, Radix Salviae Miltiorrhizae 40-80 part, Semen Persicae 40-80 part, Herba Artemisiae Annuae 40-80 part, Rhizoma Chuanxiong 40-80 part, Radix Angelicae Sinensis 30-70 part, Radix Paeoniae Alba 30-70 part, Fructus Gardeniae (parched) 30-70 part, Rhizoma Cyperi 30-70 part, Cortex Moutan 20-60 part, Herba Menthae 20-60 part, Stigma Croci 3-7 part.
Further preferably, the Chinese medicine composition of spot-removing beautifying face provided by the invention contains following parts by weight of Chinese traditional medicine: 60 parts of Radix Bupleuri, 60 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts in Rhizoma Zingiberis Recens, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts in Semen Persicae, 60 parts of Herba Artemisiae Annuaes, 60 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 50 parts of the Radix Paeoniae Albas, 50 parts of Fructus Gardeniae (parched), 50 parts of Rhizoma Cyperis, 40 parts of Cortex Moutans, 40 parts of Herba Menthaes, 5 parts of Stigma Crocis.
Described Radix Bupleuri is preferably Radix Bupleuri (processed with vinegar); The Rhizoma Atractylodis Macrocephalae is preferably Rhizoma Atractylodis Macrocephalae (parched with bran); Radix Salviae Miltiorrhizae is preferably Radix Salviae Miltiorrhizae; Radix Angelicae Sinensis is preferably Radix Angelicae Sinensis (steamed); The Radix Paeoniae Alba is preferably Radix Paeoniae Alba (processed with wine).
The present invention also provides the method for preparing above-mentioned Chinese medicine composition, and this method may further comprise the steps:
1) Stigma Croci ethanol extraction 2-5 time extracted 0.5-3 hour at every turn, filter, and merging filtrate, filtrate recycling ethanol also is concentrated into the concentrated solution that relative density is 1.05 (30 ℃), and is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross the 40-200 mesh sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2-5 time, decocting time is 0.5-3 hour, collecting decoction, be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make it contain alcohol amount to reach 60%, left standstill 12-36 hour, filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 60-85 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, mixing, namely.
In the said method:
Described concentration of ethanol is 30-80%, and consumption is that the 1-5 of croceous weight doubly measures;
When decocting boils in the described step 3), the consumption of water be medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan weight 1-5 doubly.
Chinese medicine composition provided by the invention can directly be prepared into various dosage forms, also can be prepared into various dosage forms with pharmaceutically acceptable carrier combinations.
Described dosage form is sheet, hard capsule, granule, granule, soft capsule or pill.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier of pharmaceutical field routine, are selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Described binding agent is selected from cellulose derivative, alginate, ethanol, gelatin or polyvinylpyrrolidone etc.;
Described disintegrating agent is selected from microcrystalline Cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate;
Described suspending agent is selected from micropowder silica gel, Cera Flava, cellulose, solid polyethylene glycol;
Described wetting agent is selected from glycerol, tween 80, ethyoxyl castor oil hydrogenated or lecithin;
Described solvent is selected from ethanol, liquid polyethylene glycol, isopropyl alcohol, glycerol, propylene glycol or vegetable oil, and described vegetable oil is selected from soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods;
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, polyoxyethylene-polyoxypropylene copolymer, the fatty acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.;
Described sweeting agent is selected from aspartame, Sucralose, essence, citric acid or saccharin sodium.
The present invention also provides above-mentioned Chinese medicine composition and its preparation in preparation treatment chloasma faciei, the health product of pigment or the application on the medicine.
Not provided by the invention not being taken by pregnant women.
Chinese medicine composition provided by the invention has the following advantages:
1, in the medicine of the present invention:
Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..Radix Bupleuri (processed with vinegar) suffering, hardship are slightly cold.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for cold, fever, alternate attack of chill and fever, sternal rib pain, menoxenia, uterine prolapse, proctoptosis.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Rhizoma Atractylodis Macrocephalae (parched with bran) bitter in the mouth, sweet, warm.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Rhizoma Zingiberis Recens is the fresh rhizome of zingiber Zingiber officinale Rosc..Acrid in the mouth, tepor.Return lung, spleen, stomach warp.The cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, solving toxin of fish and crab.Be used for anemofrigid cold, gastrofrigid vomiting, the cold-phlegm cough, the fish Eriocheir sinensis poisons.
Radix Salviae Miltiorrhizae is dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Bitter in the mouth is slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle.Be used for obstruction of qi in the chest and cardialgia, gastral cavity abdominal rib Tong ， lumps in the chest and abdomen, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, the dysmenorrhea amenorrhea, skin infection swells and ache.
Semen Persicae is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunusdavidiana (Carr.) Franch. dry mature seed.Bitter in the mouth, sweet is flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea dysmenorrhea ， mass in the abdomen mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Herba Artemisiae Annuae is the dry aerial parts of feverfew Herba Artemisiae annuae Artemisia annua L..Bitter in the mouth, suffering, cold.Return liver, gallbladder meridian.Clearind deficient heat except hectic fever due to YIN-deficiency, is separated summer-heat, cut cruel, jaundice eliminating.Be used for the pathogenic warmth impairment of YIN, night fever abating at dawn, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, pathogenic summer-heat heating, malaria cold and heat, jaundice due to damp-heat.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Acrid in the mouth, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for obstruction of qi in the chest and cardialgia, costa sternales twinge, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, headache, rheumatic arthralgia.
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Sweet in the mouth, suffering, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Bitter in the mouth, acid is slightly cold.Return liver, spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Be used for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, costalgia, stomachache, limb pain twin, it is dizzy to have a headache.
Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.Bitter in the mouth, cold.GUIXIN, lung, tri-jiao channel.The pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The externally used detumescence pain relieving.It is vexed to be used for calentura, jaundice due to damp-heat, and the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Acrid in the mouth, little hardship, little sweet, flat.Return liver, spleen, tri-jiao channel.Dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, sternal rib pain, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
Cortex Moutan is the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Bitter in the mouth, suffering are slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Be used for heat and go into nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, the amenorrhea dysmenorrhea is fallen and is pounced on the pain of injury, too fat to move sore.
Herba Menthae is the dry aerial parts of labiate Mentha haplocalyx Briq..Acrid in the mouth, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, costa sternales feeling of distension and oppression.
Stigma Croci is the dry stigma of irides Stigma Croci Crocus sativus L..Sweet in the mouth is flat.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Play liver-smoothing, qi-regulating, constraint eliminating and menstruation regulating, invigorate blood circulation full side, the effect of blood stasis dispelling, speckle dispelling, is applicable to chloasma faciei, pigmentation.
2, through clinical experience for many years, finally determined the present invention, experimental result shows: Chinese medicine composition provided by the invention has treatment chloasma faciei, Pigmented effect, and effect is better than prior art.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 60g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 60g, Rhizoma Zingiberis Recens 60g, Radix Salviae Miltiorrhizae 60g, Semen Persicae 60g, Herba Artemisiae Annuae 60g, Rhizoma Chuanxiong 60g, Radix Angelicae Sinensis (steaming) 50g, the Radix Paeoniae Alba (wine is processed) 50g, Fructus Gardeniae (parched) 50g, Rhizoma Cyperi 50g, Cortex Moutan 40g, Herba Menthae 40g, Stigma Croci 5g.
2, preparation method:
1) Stigma Croci adds 50% ethanol of 2 times of amounts of Stigma Croci weight with extracting 2 times at every turn, and extraction time is: 1 hour for the first time, and 0.5 hour for the second time, filter, it is the concentrated solution of 1.05 (30 ℃) that merging filtrate, filtrate recycling ethanol are concentrated into to relative density, standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross 40 mesh sieves, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 3 times, add 2 times water of nine highly seasoned amounts such as medicinal residues and all the other Radix Bupleuri at every turn, extracted 2 hours for the first time, extracted 1 hour for the second time, extracted for the third time 1 hour, collecting decoction is concentrated into relative density 1.05 (30 ℃), adding ethanol makes content reach 60%, left standstill 24 hours, and filtered, be condensed into the thick paste of relative density 1.30 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and makes 1000, namely.
Embodiment 2: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 80g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 40g, Rhizoma Zingiberis Recens 80g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 40g, Herba Artemisiae Annuae 40g, Rhizoma Chuanxiong 40g, Radix Angelicae Sinensis (steaming) 70g, the Radix Paeoniae Alba (wine is processed) 30g, Fructus Gardeniae (parched) 30g, Rhizoma Cyperi 50g, Cortex Moutan 60g, Herba Menthae 20g, Stigma Croci 5g.
2, preparation method:
1) Stigma Croci adds 2 times 60% ethanol of Stigma Croci weight with ethanol extraction 3 times at every turn, and extraction time is: 1 hour for the first time, and 0.5 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2 times, add 3 times water of nine highly seasoned amounts such as medicinal residues and all the other Radix Bupleuri, extraction time is at every turn: 2 hours for the first time, and 1 hour for the second time, collecting decoction, be concentrated into relative density 1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 12 hours, filter, be condensed into the thick paste of relative density 1.30 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, adds the starch of 20g, and mixing incapsulates, and makes 1000, namely.
Embodiment 3: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 40g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 80g, Rhizoma Zingiberis Recens 40g, Radix Salviae Miltiorrhizae 40g, Semen Persicae 80g, Herba Artemisiae Annuae 80g, Rhizoma Chuanxiong 60g, Radix Angelicae Sinensis (steaming) 30g, the Radix Paeoniae Alba (wine is processed) 50g, Fructus Gardeniae (parched) 70g, Rhizoma Cyperi 60g, Cortex Moutan 50g, Herba Menthae 50g, Stigma Croci 5g.
2, preparation method:
1) Stigma Croci is with ethanol extraction 3 times, adds 3 times of Stigma Croci weight 60% ethanol at every turn, and extraction time is: 1.5 hours for the first time, and 1 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2 times, add 3 times water of medicinal residues and all the other nine flavor medicine weight, decocting time is at every turn: 2 hours for the first time, and 1 hour for the second time, collecting decoction, be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 36 hours, filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and makes 1000, namely.
Embodiment 4: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 20g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 100g, Rhizoma Zingiberis Recens 80g, Radix Salviae Miltiorrhizae 80g, Semen Persicae 100g, Herba Artemisiae Annuae 50g, Rhizoma Chuanxiong 50g, Radix Angelicae Sinensis (steaming) 30g, the Radix Paeoniae Alba (wine is processed) 10g, Fructus Gardeniae (parched) 80g, Rhizoma Cyperi 70g, Cortex Moutan 40g, Herba Menthae 10g, Stigma Croci 5g.
2, preparation method:
1) Stigma Croci is with ethanol extraction 3 times, adds 5 times of Stigma Croci weight 30% ethanol at every turn, and 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2 times, 3 times the water that adds medicinal residues and all the other nine flavor medicine weight, 2 hours for the first time, 1 hour for the second time, collecting decoction, be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours, filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, be ground into fine powder, sieve, volatile oil sprays into dissolve with ethanol, adds microcrystalline Cellulose, the 5g starch of 10g again, mixing incapsulates, and makes 1000, namely.
Embodiment 5: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 100g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 20g, Rhizoma Zingiberis Recens 40g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 30g, Herba Artemisiae Annuae 100g, Rhizoma Chuanxiong 20g, Radix Angelicae Sinensis (steaming) 80g, the Radix Paeoniae Alba (wine is processed) 80g, Fructus Gardeniae (parched) 30g, Rhizoma Cyperi 50g, Cortex Moutan 60g, Herba Menthae 20g, Stigma Croci 5g.
2, preparation method:
1) Stigma Croci is with ethanol extraction 3 times, adds 65% ethanol of 3 times of amounts of Stigma Croci weight at every turn, and decocting time is: 1 hour for the first time, and 1 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also are concentrated into an amount of, and concentrated solution is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2 times, amount of water is medicinal residues and all the other nine flavor medicine weight 2 times, and decocting time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction, be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours, filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃);
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and makes 1000, namely.
Embodiment 6: spot removing and face nursing capsule
1, Chinese medicine is formed: Radix Bupleuri (processed with vinegar) 50g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 50g, Rhizoma Zingiberis Recens 50g, Radix Salviae Miltiorrhizae 50g, Semen Persicae 50g, Herba Artemisiae Annuae 50g, Rhizoma Chuanxiong 50g, Radix Angelicae Sinensis (steaming) 40g, the Radix Paeoniae Alba (wine is processed) 40g, Fructus Gardeniae (parched) 40g, Rhizoma Cyperi 30g, Cortex Moutan 30g, Herba Menthae 30g, Stigma Croci 3g.
2, preparation method:
1) Stigma Croci is with 70% ethanol extraction 3 times, and the amount that adds ethanol for three times is respectively 3 times, 1.5 times, 1.5 times, and decocting time is: 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the second time, filter, merging filtrate, filtrate recycling ethanol also is concentrated in right amount, and concentrated solution is standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2 times, amount of water is medicinal residues and all the other nine flavor medicine weight 2 times, and decocting time is: 2 hours for the first time, and 1 hour for the second time, collecting decoction, be concentrated into relative density 1.05-1.10 (30 ℃), add ethanol and make content reach 60%, left standstill 24 hours, filter, be condensed into the thick paste of relative density 1.30-1.40 (50 ℃).The Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 80 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, and mixing incapsulates, and makes 1000, namely.
Experimental example: effect experiment
1, experimental data
128 routine patients are the women, age 24-52 year, 27-37 year 92 examples (72%), course of disease 0.5-12, butterfly 86 examples in the majority (67%), other 3 type, 42 examples (23%).
2, clinical diagnosis standard: according to CAIM (Chinese Association Of Integrative Medicine) Dermatology Professional Committee pigment group " clinical diagnosis of chloasma and curative effect " diagnosis and typing.
3, Therapeutic Method:
According to pill taker voluntarily and on request, divide treatment by Chinese herbs group and western medicine group.Chinese drug-treated group 73 examples wherein, Western medicine group 55 examples.Poor different no significances such as two groups of patient's Clinical typings, age, the course of disease, wherein:
Chinese drug-treated group: take spot removing and face nursing capsule (product of embodiments of the invention 1 preparation, called after spot removing and face nursing capsule), oral, each 1.6g, every day 3 times.(2) Western medicine group: VITAMIN C TABLET, 0.2g, 3 times/day, oral, vitamin E drop pill 0.1g, 3 times/day are oral.Without other drug, 1 month course for the treatment of, treat 3 post-evaluation course for the treatment of curative effects during two groups of treatments.
4, observational technique:
Observe and treat onset time: point system, standard and the equal reference literature of scoring decline index note point methods.Per 2 all further consultation record pigment situations of change.Compare two groups of curative effects and healing time.
The judgement of clinical efficacy:
Basic cure disappear for naked eyes visual pigment speckle area＞90%, color disappears substantially, decline index 〉=0.5 of marking;
Progressive color is thin out for the pigmented spots area disappears 30%, scoring decline index 〉=0.3.Invalidly disappear for naked eyes visual pigment speckle area＜30%;
Effectively add produce effects note point with basic healing.
5, result: see Table 1
Table 1
| Case load | The basic healing | Produce effects | Progressive | Invalid | Total effective rate | |
| Chinese drug-treated group | 73 | 26 examples (35.6%) | 31 examples (42.5%) | 15 examples (20.5%) | 1 example (1.4%) | 78.1％ |
| The Western medicine group | 55 | 8 examples (14.5%) | 15 examples (27.3%) | 29 examples (52.7%) | 3 examples (5.5%) | Total effective rate 41.8% |
As can be seen from Table 1: embodiment 1 effect provided by the invention is better than the Western medicine group.
Two groups of healing times: Chinese medicine spot removing and face nursing capsule group 68 ± 13 days, Western medicine group 76 ± 11 days, two groups of comparing differences have significance.
Equally, all the other embodiment and all the other proportionings of the present invention are experimentized, effect is similar to Example 1.
6, conclusion: Chinese medicine composition provided by the invention has treatment chloasma faciei, Pigmented effect, and effect is better than prior art.
Though, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. the Chinese medicine composition of a spot-removing beautifying face, it is characterized in that this Chinese medicine composition is made by following parts by weight of Chinese traditional medicine: Radix Bupleuri 10-100 part, Rhizoma Atractylodis Macrocephalae 10-100 part, Rhizoma Zingiberis Recens 10-100 part, Radix Salviae Miltiorrhizae 10-100 part, Semen Persicae 10-100 part, Herba Artemisiae Annuae 10-100 part, Rhizoma Chuanxiong 10-100 part, Radix Angelicae Sinensis 20-80 part, Radix Paeoniae Alba 20-80 part, Fructus Gardeniae (parched) 20-80 part, Rhizoma Cyperi 20-80 part, Cortex Moutan 10-70 part, Herba Menthae 10-70 part, Stigma Croci 1-10 part.
2. Chinese medicine composition according to claim 1, it is characterized in that this Chinese medicine composition is made by following parts by weight of Chinese traditional medicine: Radix Bupleuri 40-80 part, Rhizoma Atractylodis Macrocephalae 40-80 part, Rhizoma Zingiberis Recens 40-80 part, Radix Salviae Miltiorrhizae 40-80 part, Semen Persicae 40-80 part, Herba Artemisiae Annuae 40-80 part, Rhizoma Chuanxiong 40-80 part, Radix Angelicae Sinensis 30-70 part, Radix Paeoniae Alba 30-70 part, Fructus Gardeniae (parched) 30-70 part, Rhizoma Cyperi 30-70 part, Cortex Moutan 20-60 part, Herba Menthae 20-60 part, Stigma Croci 3-7 part.
3. Chinese medicine composition according to claim 1, it is characterized in that this Chinese medicine composition is made by following parts by weight of Chinese traditional medicine: 60 parts of Radix Bupleuri, 60 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts in Rhizoma Zingiberis Recens, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts in Semen Persicae, 60 parts of Herba Artemisiae Annuaes, 60 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 50 parts of the Radix Paeoniae Albas, 50 parts of Fructus Gardeniae (parched), 50 parts of Rhizoma Cyperis, 40 parts of Cortex Moutans, 40 parts of Herba Menthaes, 5 parts of Stigma Crocis.
4. according to each described Chinese medicine composition of claim 1-3, it is characterized in that described Radix Bupleuri is Radix Bupleuri (processed with vinegar); The Rhizoma Atractylodis Macrocephalae is Rhizoma Atractylodis Macrocephalae (parched with bran); Radix Salviae Miltiorrhizae is Radix Salviae Miltiorrhizae; When being classified as Radix Angelicae Sinensis (steamed); The Radix Paeoniae Alba is Radix Paeoniae Alba (processed with wine).
5. method for preparing each described Chinese medicine composition of claim 1-4, this method may further comprise the steps:
1) Stigma Croci extracted 0.5-3 hour with ethanol extraction 2-5 time at every turn, filtration, merging filtrate, filtrate recycling ethanol and when being concentrated into 30 ℃ relative density be 1.05 concentrated solution, standby;
2) Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are ground into fine powder, sieve, and be standby;
3) Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, aqua methnae steam distillation, device is collected distillate in addition; Medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan, decoct with water 2-5 time, decocting time is 0.5-3 hour, collecting decoction, relative density 1.05-1.10 when being concentrated into 30 ℃ adds ethanol and makes it contain alcohol amount to reach 60%, left standstill 12-36 hour, filter, relative density is the thick paste of 1.30-1.40 when being condensed into 50 ℃;
4) the Stigma Croci concentrated solution is added in the above-mentioned thick paste, stir, mixing adds the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba fine powder, dry below 60-85 ℃, is ground into fine powder, sieves, and volatile oil sprays into dissolve with ethanol, mixing, namely.
6. method according to claim 5 is characterized in that, described concentration of ethanol is 30-80%, and consumption is 1-5 times of Stigma Croci weight; When decocting boils in the described step 3), the consumption of water be medicinal residues and Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Salviae Miltiorrhizae, Herba Artemisiae Annuae, Fructus Gardeniae (parched), Rhizoma Cyperi, Cortex Moutan weight 1-5 doubly.
7. contain the preparation that right requires each described Chinese medicine composition of 1-4, said preparation is made up of this Chinese medicine composition and pharmaceutically acceptable carrier.
8. preparation according to claim 7 is characterized in that, described preparation is sheet, hard capsule, granule, soft capsule, oral liquid or pill.
9. preparation according to claim 7, it is characterized in that, described pharmaceutically acceptable carrier refers to the pharmaceutical carrier of pharmaceutical field routine, is selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
10. each described Chinese medicine composition of claim 1-4 or each described preparation of claim 7-9 application in preparation treatment chloasma faciei, Pigmented health product and medicine.
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