CN104922426A - Pharmaceutical composition for treating post gynecologic operation low fever - Google Patents

Abstract

A pharmaceutical composition for treating post gynecologic operation low fever comprises the following raw material drugs: turtle shell, dahurian patrinia herb, rhizoma cimicifugae, momordica grosvenori, caulis spatholobi, artemisia apiacea, fritillaria, Paris polyphylla, common andrographis herb, radix pueraiae, liquorice, radix paeoniae alba, common cephalanoplos herb, portulaca oleracea, honeysuckle, hawthorn, motherwort, cassia twig, radix sophorae flavescentis, angelica sinensis, immature bitter orange, oldenlandia diffusa, Chinese yam, calcined oyster shell, large-leaved gentian, smoked plum, schisandra chinensis, ligusticum wallichii, mangnolia officinalis and Chinese dates. The raw material drug are combined for use, the medication is appropriate, the compatibility is simple, a distinction is made between the primary thing and secondary thing, both symptoms and root causes can be treated, the post gynecologic operation low fever can be effectively treated, the rehabilitation time of patients can be greatly shortened, the physical quality and living quality of patients can be improved and optimized, and an excellent treatment effect is achieved in clinical tests.

Description

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of pharmaceutical composition for the treatment of post gynecologic operation low fever.

Background technology

Post gynecologic operation low fever belongs to very general clinical obstetrical and gynecological disease, its clinical symptoms mainly comprises cough, cardiopalmus, inappetence, weak, dizzy etc., and main induced factor is cause body temperature nerve centre impaired under tuberculosis, rheumatism etc. inflammatory reaction and human body are in immense pressure for a long time.Many-sided reason can cause lasting low grade fever, and the mood of patient also has close ties with the morbidity of this disease.Current western medicine many employings intravenous antibiotics, cost is high, and side effect is large, still lacks the medicine effectively can treating post gynecologic operation low fever in doctor trained in Western medicine and the traditional Chinese medical science.

Summary of the invention

The object of this invention is to provide a kind of prepare easy, cost is low, evident in efficacy, the pharmaceutical composition for the treatment of post gynecologic operation low fever that has no side effect.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Treat a pharmaceutical composition for post gynecologic operation low fever, the crude drug of described pharmaceutical composition is made up of Carapax Trionycis, Herba Patriniae, Rhizoma Cimicifugae, Fructus Momordicae, Caulis Spatholobi, Herba Artemisiae Annuae, Bulbus Fritillariae Uninbracteatae, Rhizoma Paridis, Herba Andrographis, Radix Puerariae, Radix Glycyrrhizae, the Radix Paeoniae Alba, HERBA CIRSII, Herba Portulacae, Flos Lonicerae, Fructus Crataegi, Herba Leonuri, Ramulus Cinnamomi, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Hedyotidis Diffusae, Rhizoma Dioscoreae, Concha Ostreae (calcined), Radix Gentianae Macrophyllae, Fructus Mume, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, Cortex Magnoliae Officinalis, Fructus Jujubae.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: Radix Glycyrrhizae 12-20 part, Herba Hedyotidis Diffusae 10-16 part, Radix Sophorae Flavescentis 3-8 part, Carapax Trionycis 5-12 part, Rhizoma Cimicifugae 12-17 part, Herba Patriniae 7-12 part, Ramulus Cinnamomi 4-9 part, Fructus Crataegi 15-20 part, Cortex Magnoliae Officinalis 10-15 part, Flos Lonicerae 8-12 part, Herba Leonuri 2-5 part, Bulbus Fritillariae Uninbracteatae 3-7 part, Caulis Spatholobi 11-14 part, Rhizoma Paridis 9-15 part, Fructus Momordicae 3-6 part, Herba Portulacae 8-13 part, Concha Ostreae (calcined) 3-5 part, Herba Andrographis 1-3 part, Radix Angelicae Sinensis 5-10 part, Radix Puerariae 5-10 part, Fructus Mume 13-16 part, Herba Artemisiae Annuae 3-10 part, Fructus Aurantii Immaturus 8-13 part, Rhizoma Dioscoreae 3-5 part, Radix Paeoniae Alba 1-3 part, Rhizoma Chuanxiong 5-10 part, Fructus Jujubae 3-6 part, HERBA CIRSII 8-13 part, Radix Gentianae Macrophyllae 3-5 part, Fructus Schisandrae Chinensis 4-8 part.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 12 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 16 parts, Radix Sophorae Flavescentis 3 parts, Carapax Trionycis 12 parts, Rhizoma Cimicifugae 12 parts, Herba Patriniae 10 parts, Ramulus Cinnamomi 9 parts, Fructus Crataegi 15 parts, Cortex Magnoliae Officinalis 15 parts, Flos Lonicerae 8 parts, Herba Leonuri 5 parts, Bulbus Fritillariae Uninbracteatae 3 parts, Caulis Spatholobi 14 parts, Rhizoma Paridis 9 parts, Fructus Momordicae 6 parts, Herba Portulacae 8 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 1 part, Radix Angelicae Sinensis 10 parts, Radix Puerariae 5 parts, Fructus Mume 16 parts, Herba Artemisiae Annuae 10 parts, Fructus Aurantii Immaturus 8 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 1 part, Rhizoma Chuanxiong 10 parts, 6 parts, Fructus Jujubae, HERBA CIRSII 8 parts, Radix Gentianae Macrophyllae 3 parts, Fructus Schisandrae Chinensis 4 parts.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 20 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 parts, Radix Sophorae Flavescentis 8 parts, Carapax Trionycis 5 parts, Rhizoma Cimicifugae 17 parts, Herba Patriniae 12 parts, Ramulus Cinnamomi 4 parts, Fructus Crataegi 20 parts, Cortex Magnoliae Officinalis 10 parts, Flos Lonicerae 12 parts, Herba Leonuri 2 parts, Bulbus Fritillariae Uninbracteatae 7 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 15 parts, Fructus Momordicae 3 parts, Herba Portulacae 13 parts, Concha Ostreae (calcined) 3 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 5 parts, Radix Puerariae 10 parts, Fructus Mume 13 parts, Herba Artemisiae Annuae 3 parts, Fructus Aurantii Immaturus 13 parts, Rhizoma Dioscoreae 3 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 5 parts, 4 parts, Fructus Jujubae, HERBA CIRSII 10 parts, Radix Gentianae Macrophyllae 4 parts, Fructus Schisandrae Chinensis 5 parts.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 13 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 parts, Radix Sophorae Flavescentis 4 parts, Carapax Trionycis 6 parts, Rhizoma Cimicifugae 13 parts, Herba Patriniae 7 parts, Ramulus Cinnamomi 5 parts, Fructus Crataegi 18 parts, Cortex Magnoliae Officinalis 11 parts, Flos Lonicerae 9 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 6 parts, Caulis Spatholobi 12 parts, Rhizoma Paridis 13 parts, Fructus Momordicae 4 parts, Herba Portulacae 9 parts, Concha Ostreae (calcined) 4 parts, Herba Andrographis 2 parts, Radix Angelicae Sinensis 6 parts, Radix Puerariae 6 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 5 parts, Fructus Aurantii Immaturus 10 parts, Rhizoma Dioscoreae 4 parts, the Radix Paeoniae Alba 2 parts, Rhizoma Chuanxiong 6 parts, 5 parts, Fructus Jujubae, HERBA CIRSII 12 parts, Radix Gentianae Macrophyllae 3 parts, Fructus Schisandrae Chinensis 6 parts.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 17 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 15 parts, Radix Sophorae Flavescentis 7 parts, Carapax Trionycis 11 parts, Rhizoma Cimicifugae 16 parts, Herba Patriniae 8 parts, Ramulus Cinnamomi 8 parts, Fructus Crataegi 16 parts, Cortex Magnoliae Officinalis 14 parts, Flos Lonicerae 11 parts, Herba Leonuri 3 parts, Bulbus Fritillariae Uninbracteatae 5 parts, Caulis Spatholobi 13 parts, Rhizoma Paridis 14 parts, Fructus Momordicae 5 parts, Herba Portulacae 12 parts, Concha Ostreae (calcined) 3 parts, Herba Andrographis 1 part, Radix Angelicae Sinensis 10 parts, Radix Puerariae 9 parts, Fructus Mume 13 parts, Herba Artemisiae Annuae 7 parts, Fructus Aurantii Immaturus 11 parts, Rhizoma Dioscoreae 3 parts, the Radix Paeoniae Alba 1 part, Rhizoma Chuanxiong 10 parts, 4 parts, Fructus Jujubae, HERBA CIRSII 11 parts, Radix Gentianae Macrophyllae 4 parts, Fructus Schisandrae Chinensis 7 parts.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 15 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 parts, Radix Sophorae Flavescentis 5 parts, Carapax Trionycis 9 parts, Rhizoma Cimicifugae 15 parts, Herba Patriniae 9 parts, Ramulus Cinnamomi 7 parts, Fructus Crataegi 19 parts, Cortex Magnoliae Officinalis 13 parts, Flos Lonicerae 10 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 4 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 11 parts, Fructus Momordicae 5 parts, Herba Portulacae 10 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 8 parts, Radix Puerariae 8 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 9 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 8 parts, 6 parts, Fructus Jujubae, HERBA CIRSII 9 parts, Radix Gentianae Macrophyllae 5 parts, Fructus Schisandrae Chinensis 7 parts.

Further, crude drug composition and the parts by weight of making described pharmaceutical composition are: 19 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 14 parts, Radix Sophorae Flavescentis 6 parts, Carapax Trionycis 7 parts, Rhizoma Cimicifugae 14 parts, Herba Patriniae 9 parts, Ramulus Cinnamomi 6 parts, Fructus Crataegi 17 parts, Cortex Magnoliae Officinalis 13 parts, Flos Lonicerae 10 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 4 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 11 parts, Fructus Momordicae 5 parts, Herba Portulacae 10 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 8 parts, Radix Puerariae 8 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 4 parts, Fructus Aurantii Immaturus 9 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 8 parts, 3 parts, Fructus Jujubae, HERBA CIRSII 8 parts, Radix Gentianae Macrophyllae 5 parts, Fructus Schisandrae Chinensis 8 parts.

Further, described pharmaceutical composition adopts following preparation steps:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained is put into super micron mill and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, drying, granulate, can obtain granule; Or put into super micron mill after the dry extract drying obtained by step (2) and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, make powder; Or the dry extract that step (2) is obtained is put into super micron mill and pulverizes 1-2 hour, sieve, obtain 100-200 object micropowders, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or the dry extract that step (2) is obtained is put into super micron mill and pulverizes 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to the application of a kind of described pharmaceutical composition in treatment post gynecologic operation low fever medicine.

The pharmaceutical composition for the treatment of post gynecologic operation low fever provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Carapax Trionycis, salty, be slightly cold.Return liver, kidney channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.

Herba Patriniae: acrid in the mouth, hardship, be slightly cold.Return liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.For acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, breast abdomen pain, puerperal abdonimal pain, dysmenorrhea.

Rhizoma Cimicifugae, pungent, micro-sweet, be slightly cold.Return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.

Fructus Momordicae, sweet, cool.Return lung, large intestine channel.Function cures mainly: clearing heat and moistening lung, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Herba Artemisiae Annuae, bitter, acrid, cold.Return liver, gallbladder meridian.Function cures mainly: clearing away summer-heat, except steaming, and preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.

Bulbus Fritillariae Uninbracteatae, bitter in the mouth, gas is put down, be slightly cold, nontoxic.Enter lung, stomach, spleen, the heart four warp.The heat-phlegm that disappears is the most sharp, and only chronic cough should be used, and can separate in the heart against the how melancholy person of gas, and the disease of the sthenia cold fullness of chest that cures the wound, treat elbow-knee ulceration's efficiency.

Rhizoma Paridis hardship is slightly cold, and returns Liver Channel, function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, and Radix Sophorae Flavescentis is bitter, and cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, have heat clearing and damp drying, parasite killing, the merit of diuresis.

Herba Andrographis: bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, removing heat from blood, and detumescence, effect of dampness, cures mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, the cards such as venom.

Radix Puerariae, sweet in the mouth, pungent, cool in nature.Enter spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect that relieving restlessness is only warm.For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.Be used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity.

Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong.

The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, is classified as middle product, and note has " main pathogen, the Radix Paeoniae Alba is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.

HERBA CIRSII, sweet, bitter, cold.GUIXIN, Liver Channel.Cooling blood for hemostasis, dissipating blood stasis removing toxicity for eliminating carbuncles.Heat in blood goes out blood disorder.This moral character belongs to cold and cool, the kind heat to purify the blood point and cooling blood for hemostasis, no matter tells and coughs up epistaxis, metrorrhagia of having blood in stool etc. hemorrhage caused by bleeding due to blood-heat person all can select.Double energy inducing diuresis for treating stranguria syndrome, therefore outstanding being apt to controls hematuria, stranguria with blood, can apply by single, also can the compatibility Radix Rehmanniae, Talcum, Fructus Gardeniae, Herba Lophatheri etc.Pyretic toxicity carbuncle.This product energy heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, with controlling pathopyretic ulcer from the beginning of the card swollen and ache.

Herba Portulacae, acid, cold.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Flos Lonicerae: the flower that the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglaucaMiq., Flos Lonicerae Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or band are just opened.Property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.

Fructus Crataegi is the fruit of Flos Rosae Multiflorae tannin plant Fructus Crataegi or Crataegi cuneatae, its acid, sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, diuresis, effect of antidiarrheal.After human body takes Fructus Crataegi, the activity of enzyme in stomach can be increased, promote food digestion, circulation of qi promoting dissipating blood stasis, be beneficial to the meat that disappears and amass.

Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Ramulus Cinnamomi acrid-sweet flavor, warm in nature, it is the interior temperature medicine that interior cold is commonly used, there is effect of complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, has the effect of significantly analgesia and anti-cancer and cancer-preventing.

Radix Sophorae Flavescentis: bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Radix Angelicae Sinensis: sweet, pungent, warm.Return liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

Fructus Aurantii Immaturus: temperature; Bitter, pungent, sour; Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance, often utilize Herba Hedyotidis Diffusae anticancer, and it has certain radiation resistance.

Rhizoma Dioscoreae: sweet in the mouth, property is flat, nontoxic, returns spleen, lung, kidney channel; principle active component dioscin is a kind of polysaccharide; there is protective effect to the rat Langerhans islet B cell damage caused by alloxan, have hypoglycemic activity to fasting rat and rabbit, the hyperglycemia that alloxan etc. causes can be controlled.

Concha Ostreae (calcined), salty, be slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Radix Gentianae Macrophyllae, toil, flat.Enter liver, stomach, gallbladder meridian.Function cures mainly: expelling wind and removing dampness, and blood relaxing muscles and tendons, clearing away heat and promoting diuresis.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.

Fructus Mume: property of medicine acid is puckery, flat.Return liver, spleen, lung, large intestine channel; Effect: astringing lung-QI and relieving cough, relieving diarrhea with astringents, relieving pain by calming ascaris, promoting the production of body fluid to quench thirst.

Fructus Schisandrae Chinensis is warm in nature; Sour in the mouth, sweet, return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Thirsty for Tianjin wound, deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Modern study, containing abundant organic acid, vitamin, flavonoid, phytosterol and the lignan having potent reactivation, it is also one of the minority medical material having essence, gas, god's three large tonifications concurrently.

Rhizoma Chuanxiong, nature and flavor are pungent, temperature.Enter liver, gallbladder meridian.Cure mainly activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Cortex Magnoliae Officinalis: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Effect with cure mainly: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Effect with cure mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For the empty lack of appetite of board. weak loose stool, woman hysteria.

In pharmaceutical composition of the present invention, Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming, rash delivered by Rhizoma Cimicifugae, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy, Herba Artemisiae Annuae clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria, Radix Puerariae yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant, Ramulus Cinnamomi complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach, Concha Ostreae (calcined) tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, Carapax Trionycis, Rhizoma Cimicifugae, Herba Artemisiae Annuae, Radix Puerariae, the Radix Paeoniae Alba, Ramulus Cinnamomi, Concha Ostreae (calcined) are monarch drug, Flos Lonicerae dispelling wind-heat, removing summer-heat blood poison, Herba Patriniae heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing, Bulbus Fritillariae Uninbracteatae disappears heat-phlegm, Rhizoma Paridis heat-clearing and toxic substances removing, reducing swelling and alleviating pain, Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness, HERBA CIRSII cooling blood for hemostasis, dissipating blood stasis removing toxicity for eliminating carbuncles, Herba Portulacae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Radix Sophorae Flavescentis heat clearing and damp drying, parasite killing, diuresis, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, promoting diuresis to eliminate damp pathogen, Radix Gentianae Macrophyllae expelling wind and removing dampness, with blood relaxing muscles and tendons, clearing away heat and promoting diuresis, Flos Lonicerae, Herba Patriniae, Bulbus Fritillariae Uninbracteatae, Rhizoma Paridis, Herba Andrographis, HERBA CIRSII, Herba Portulacae, Radix Sophorae Flavescentis, Herba Hedyotidis Diffusae, Radix Gentianae Macrophyllae is ministerial drug, Fructus Momordicae clearing heat and moistening lung, laxation relieving constipation, Caulis Spatholobi is enriched blood, invigorate blood circulation, dredging collateral, hawthorn digesting amasss, dissipating blood stasis blood, diuresis, antidiarrheal, Herba Leonuri is invigorated blood circulation, blood stasis dispelling, regulating menstruation, disappear water, Chinese angelica blood supplementing, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy, to reduce phlegm loose painful abdominal mass, Chinese yam spleen-strengtheningporridge the kidney invigorating, Fructus Mume astringing lung-QI and relieving cough, relieving diarrhea with astringents, relieving pain by calming ascaris, promoting the production of body fluid to quench thirst, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming, Rhizoma Chuanxiong activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain, the expectorant of Cortex Magnoliae Officinalis dampness, the therapeutic method to keep the adverse QI flowing downwards is except full, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, Fructus Momordicae, Caulis Spatholobi, Fructus Crataegi, Herba Leonuri, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Rhizoma Dioscoreae, Fructus Mume, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, Cortex Magnoliae Officinalis, Fructus Jujubae is adjuvant drug, Radix Glycyrrhizae has effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, and medication is suitable for, and compatibility is simplified, make a distinction between the important and the lesser one, treating both the principal and secondary aspects of a disease, can effectively treat post gynecologic operation low fever, greatly can shorten the rehabilitation duration of patient, effectively improve and optimize body constitution and the quality of life of patient, clinical trial has obtained excellent therapeutic effect.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 12 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 16 grams, Radix Sophorae Flavescentis 3 grams, Carapax Trionycis 12 grams, Rhizoma Cimicifugae 12 grams, Herba Patriniae 10 grams, Ramulus Cinnamomi 9 grams, Fructus Crataegi 15 grams, Cortex Magnoliae Officinalis 15 grams, Flos Lonicerae 8 grams, Herba Leonuri 5 grams, Bulbus Fritillariae Uninbracteatae 3 grams, Caulis Spatholobi 14 grams, Rhizoma Paridis 9 grams, Fructus Momordicae 6 grams, Herba Portulacae 8 grams, Concha Ostreae (calcined) 5 grams, Herba Andrographis 1 gram, Radix Angelicae Sinensis 10 grams, Radix Puerariae 5 grams, Fructus Mume 16 grams, Herba Artemisiae Annuae 10 grams, Fructus Aurantii Immaturus 8 grams, Rhizoma Dioscoreae 5 grams, the Radix Paeoniae Alba 1 gram, Rhizoma Chuanxiong 10 grams, 6 grams, Fructus Jujubae, HERBA CIRSII 8 grams, Radix Gentianae Macrophyllae 3 grams, Fructus Schisandrae Chinensis 4 grams.

The preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1 hour: second time adds the water of 8 times amount, decocts 1h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained is put into super micron mill and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, drying, granulate, can obtain granule.

Embodiment 2:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 20 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 grams, Radix Sophorae Flavescentis 8 grams, Carapax Trionycis 5 grams, Rhizoma Cimicifugae 17 grams, Herba Patriniae 12 grams, Ramulus Cinnamomi 4 grams, Fructus Crataegi 20 grams, Cortex Magnoliae Officinalis 10 grams, Flos Lonicerae 12 grams, Herba Leonuri 2 grams, Bulbus Fritillariae Uninbracteatae 7 grams, Caulis Spatholobi 11 grams, Rhizoma Paridis 15 grams, Fructus Momordicae 3 grams, Herba Portulacae 13 grams, Concha Ostreae (calcined) 3 grams, Herba Andrographis 3 grams, Radix Angelicae Sinensis 5 grams, Radix Puerariae 10 grams, Fructus Mume 13 grams, Herba Artemisiae Annuae 3 grams, Fructus Aurantii Immaturus 13 grams, Rhizoma Dioscoreae 3 grams, the Radix Paeoniae Alba 3 grams, Rhizoma Chuanxiong 5 grams, 4 grams, Fructus Jujubae, HERBA CIRSII 10 grams, Radix Gentianae Macrophyllae 4 grams, Fructus Schisandrae Chinensis 5 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 12 times amount, decocts 1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) pulverizing 1-2 hour by putting into super micron mill after dry extract drying obtained for step (2), sieving, obtaining 100-200 object micropowders, make powder.

Embodiment 3:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 13 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 grams, Radix Sophorae Flavescentis 4 grams, Carapax Trionycis 6 grams, Rhizoma Cimicifugae 13 grams, Herba Patriniae 7 grams, Ramulus Cinnamomi 5 grams, Fructus Crataegi 18 grams, Cortex Magnoliae Officinalis 11 grams, Flos Lonicerae 9 grams, Herba Leonuri 4 grams, Bulbus Fritillariae Uninbracteatae 6 grams, Caulis Spatholobi 12 grams, Rhizoma Paridis 13 grams, Fructus Momordicae 4 grams, Herba Portulacae 9 grams, Concha Ostreae (calcined) 4 grams, Herba Andrographis 2 grams, Radix Angelicae Sinensis 6 grams, Radix Puerariae 6 grams, Fructus Mume 14 grams, Herba Artemisiae Annuae 5 grams, Fructus Aurantii Immaturus 10 grams, Rhizoma Dioscoreae 4 grams, the Radix Paeoniae Alba 2 grams, Rhizoma Chuanxiong 6 grams, 5 grams, Fructus Jujubae, HERBA CIRSII 12 grams, Radix Gentianae Macrophyllae 3 grams, Fructus Schisandrae Chinensis 6 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.15;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 48 hours, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained is put into super micron mill and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule.

Embodiment 4:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 17 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 15 grams, Radix Sophorae Flavescentis 7 grams, Carapax Trionycis 11 grams, Rhizoma Cimicifugae 16 grams, Herba Patriniae 8 grams, Ramulus Cinnamomi 8 grams, Fructus Crataegi 16 grams, Cortex Magnoliae Officinalis 14 grams, Flos Lonicerae 11 grams, Herba Leonuri 3 grams, Bulbus Fritillariae Uninbracteatae 5 grams, Caulis Spatholobi 13 grams, Rhizoma Paridis 14 grams, Fructus Momordicae 5 grams, Herba Portulacae 12 grams, Concha Ostreae (calcined) 3 grams, Herba Andrographis 1 gram, Radix Angelicae Sinensis 10 grams, Radix Puerariae 9 grams, Fructus Mume 13 grams, Herba Artemisiae Annuae 7 grams, Fructus Aurantii Immaturus 11 grams, Rhizoma Dioscoreae 3 grams, the Radix Paeoniae Alba 1 gram, Rhizoma Chuanxiong 10 grams, 4 grams, Fructus Jujubae, HERBA CIRSII 11 grams, Radix Gentianae Macrophyllae 4 grams, Fructus Schisandrae Chinensis 7 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the water boiling and extraction adding 15 times of medical material gross weight, decocts 1-2 hour: second time adds the water of 8-12 times amount, decocts 1-1.2h, leaches medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained is put into super micron mill and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet.

Embodiment 5:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 15 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 grams, Radix Sophorae Flavescentis 5 grams, Carapax Trionycis 9 grams, Rhizoma Cimicifugae 15 grams, Herba Patriniae 9 grams, Ramulus Cinnamomi 7 grams, Fructus Crataegi 19 grams, Cortex Magnoliae Officinalis 13 grams, Flos Lonicerae 10 grams, Herba Leonuri 4 grams, Bulbus Fritillariae Uninbracteatae 4 grams, Caulis Spatholobi 11 grams, Rhizoma Paridis 11 grams, Fructus Momordicae 5 grams, Herba Portulacae 10 grams, Concha Ostreae (calcined) 5 grams, Herba Andrographis 3 grams, Radix Angelicae Sinensis 8 grams, Radix Puerariae 8 grams, Fructus Mume 14 grams, Herba Artemisiae Annuae 9 grams, Fructus Aurantii Immaturus 12 grams, Rhizoma Dioscoreae 5 grams, the Radix Paeoniae Alba 3 grams, Rhizoma Chuanxiong 8 grams, 6 grams, Fructus Jujubae, HERBA CIRSII 9 grams, Radix Gentianae Macrophyllae 5 grams, Fructus Schisandrae Chinensis 7 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.5 hours: second time adds the water of 8 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Embodiment 6:

A kind of pharmaceutical composition for the treatment of post gynecologic operation low fever of the present invention, get following traditional Chinese medicine raw medicine: 19 grams, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 14 grams, Radix Sophorae Flavescentis 6 grams, Carapax Trionycis 7 grams, Rhizoma Cimicifugae 14 grams, Herba Patriniae 9 grams, Ramulus Cinnamomi 6 grams, Fructus Crataegi 17 grams, Cortex Magnoliae Officinalis 13 grams, Flos Lonicerae 10 grams, Herba Leonuri 4 grams, Bulbus Fritillariae Uninbracteatae 4 grams, Caulis Spatholobi 11 grams, Rhizoma Paridis 11 grams, Fructus Momordicae 5 grams, Herba Portulacae 10 grams, Concha Ostreae (calcined) 5 grams, Herba Andrographis 3 grams, Radix Angelicae Sinensis 8 grams, Radix Puerariae 8 grams, Fructus Mume 14 grams, Herba Artemisiae Annuae 4 grams, Fructus Aurantii Immaturus 9 grams, Rhizoma Dioscoreae 5 grams, the Radix Paeoniae Alba 3 grams, Rhizoma Chuanxiong 8 grams, 3 grams, Fructus Jujubae, HERBA CIRSII 8 grams, Radix Gentianae Macrophyllae 5 grams, Fructus Schisandrae Chinensis 8 grams.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material of components by weight percent in described Chinese medicine composition, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1.2 hours: second time adds the water of 8-12 times amount, decocts 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently;

(3) to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test:

Get mice 40, body weight 22-24 gram, be divided into 2 groups at random by body weight, treatment group and matched group: treatment group takes medicinal liquid agent prepared by the embodiment of the present invention 6, and 0.42ml/10g body weight gastric infusion is pressed in fasting after 12 hours, dose 0.395g/ml, matched group takes distilled water, three times on the one, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of pharmaceutical composition of the present invention, in January, 2013 in JIUYUE ,-2014, outpatient service place randomly draw post gynecologic operation low fever patient 180 example, patient age scope be 21-42 year, the mean age is 33.5 ± 2.2 years old, and the course of disease is 10-30 days.Before treatment, patients for a haggard face, body of the tongue is yellowish, thready and weak pulse, and with classical symptoms such as uncomfortable in chest, anorexias.Patient temperature scope: 83 examples 37.2 ~ 37.8 DEG C, 67 examples 37.9 ~ 38.2 DEG C, 30 examples 38.3 ~ 38.7 DEG C.180 routine patients are divided into treatment group and matched group at random, and 2 groups of sexes, age, courses of disease etc. compare, and difference there are no significant meaning (P > 0.05), has comparability.

Therapeutic Method:

Treatment group takes granule prepared by the embodiment of the present invention 1, an oral 10mg, twice on the one.

Matched group intravenous drip adds antibiotic sodium oxide liquid, every day 2 times; Compound aminophenazone service condition is regulated according to patient temperature change (higher than 38 DEG C).

Two groups was all 1 course for the treatment of with 20 days, and then carry out second course for the treatment of after 3 days, total course for the treatment of is 40 day time.

Criterion of therapeutical effect:

Criterion of therapeutical effect is drafted with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".

Basic healing: patient is after treatment, and body temperature is normal, and simultaneous phenomenon disappears;

Effective: patient is after treatment, and body temperature is normal, and simultaneous phenomenon disappears substantially;

Effective: patient is after treatment, and body temperature recovers normal substantially, and simultaneous phenomenon disappears substantially;

Invalid: patient is after treatment, and body temperature is unchanged, and simultaneous phenomenon does not disappear.

Effect assessment: after two courses for the treatment of, to two groups of patient view, records the contents such as its body temperature, pulse, body of the tongue.Obvious effective rate=basic cure rate+obvious effective rate.

Date processing: all data all use SPSS17.0 data analysis software to carry out statistical procedures, diversity compares employing t inspection, and measurement data represents with (x ± s), and numeration data compares uses χ ²inspection, with P < 0.05 for difference has significance.

Efficacy result:

Table 1 liang group patient effective percentage relative analysis

Group

Number of cases

Basic healing

Effective

Effectively

Invalid

Effectively total

Treatment group

90

27(30％)

54(60％)

6(6.7％)

3(3.3％)

87(96.7％)

Matched group

90

24(26.7％)

27(30％)

11(12.2％)

28(31.1％)

62(68.9％)

Table 1 result shows: granule total effective rate prepared by the embodiment of the present invention 1 is 96.7%; matched group total effective rate 68.9%; result shows; the clinical efficacy of Chinese medicine composition in treatment post gynecologic operation low fever disease prepared by technical solution of the present invention is remarkable; and the intravenous drip being better than routine adds antibiotic sodium oxide liquid, is suitable for scale clinical practice.

Model case:

Case 1

Zhao, female, 41 years old is Qingdao City Laoshan District people, goes to a doctor on March 16th, 2014.Patient has a surplus because of hyper-menorrhea for 1 year, comes my the full uterus of institute's row and adds left side attachment excision.Postoperative low grade fever is continuous, and companion's aversion to cold, spontaneous perspiration, easily hyperhidrosis, fatigue and asthenia, dizziness and blurred vision, cardiopalmus, lazy speech of breathing hard, poor appetite, pale tongue with thin fur, thready and weak pulse.The capsule giving the embodiment of the present invention 3 is treated, and twice daily, each two, 20 days courses for the treatment of, after the course for the treatment of, calorific potential is gradually moved back, and after two courses for the treatment of, then body temperature is down to normally, and all disease knowing disappear.

Case 2

Money, female, 35 years old, Qingdao Jimo people, went to a doctor on May 1st, 2014.After patient looks plasty, synechiolysis, intestinal tube kposthesis because Total hysterectomy and bilateral salpingo break, heating is not moved back (body temperature 38 ~ 38.5e) and is exceeded a few days, companion's aversion to cold, hyperhidrosis, indigestion and loss of appetite lack of appetite, xerostomia and bitter, large loose stool and not well, day row 2 times, body of the tongue is partially dark, yellow, greasy and thin fur, soft pulse is sliding.The medicine decoction giving the embodiment of the present invention 5 is treated, and twice daily, 20 days courses for the treatment of, after 2 courses for the treatment of, temperature decline to 37.5 ~ 37.8e, sweating reduces and gradually stops, and aversion to cold also subtracts, and after 1 course for the treatment of of following the service, all diseases all disappear, and body temperature is normal.

Case 3

Grandson, female, 29 years old, people from Shinan District, Qingdao City, went to a doctor on November 23rd, 2014.Patient waits to arrange and row laparoscopic surgery because of ectopic pregnancy.Postoperative 3 days, there is heating in patient, after giving antibiotic therapy, calorific potential is alleviated not yet.Postoperative 7th day, body temperature 38e, felt stomachache simultaneously, and left side is very, can touch the lump of about 2.5cm3.5cm under left abdomen otch, accompanied indigestion and loss of appetite not fragrant, and two is just normal, and body of the tongue is partially dark, yellow and greasy fur, stringy and hesitant pulse.The powder giving the embodiment of the present invention 2 is treated, and twice daily, each two bags, 20 days courses for the treatment of, after 1 course for the treatment of, namely heat decorporate, and body temperature is normal, and stomachache and abdominal part scleroma also accuse disappearance.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. treat a pharmaceutical composition for post gynecologic operation low fever, it is characterized in that: the crude drug of described pharmaceutical composition is made up of Carapax Trionycis, Herba Patriniae, Rhizoma Cimicifugae, Fructus Momordicae, Caulis Spatholobi, Herba Artemisiae Annuae, Bulbus Fritillariae Uninbracteatae, Rhizoma Paridis, Herba Andrographis, Radix Puerariae, Radix Glycyrrhizae, the Radix Paeoniae Alba, HERBA CIRSII, Herba Portulacae, Flos Lonicerae, Fructus Crataegi, Herba Leonuri, Ramulus Cinnamomi, Radix Sophorae Flavescentis, Radix Angelicae Sinensis, Fructus Aurantii Immaturus, Herba Hedyotidis Diffusae, Rhizoma Dioscoreae, Concha Ostreae (calcined), Radix Gentianae Macrophyllae, Fructus Mume, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, Cortex Magnoliae Officinalis, Fructus Jujubae.

2. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: Radix Glycyrrhizae 12-20 part, Herba Hedyotidis Diffusae 10-16 part, Radix Sophorae Flavescentis 3-8 part, Carapax Trionycis 5-12 part, Rhizoma Cimicifugae 12-17 part, Herba Patriniae 7-12 part, Ramulus Cinnamomi 4-9 part, Fructus Crataegi 15-20 part, Cortex Magnoliae Officinalis 10-15 part, Flos Lonicerae 8-12 part, Herba Leonuri 2-5 part, Bulbus Fritillariae Uninbracteatae 3-7 part, Caulis Spatholobi 11-14 part, Rhizoma Paridis 9-15 part, Fructus Momordicae 3-6 part, Herba Portulacae 8-13 part, Concha Ostreae (calcined) 3-5 part, Herba Andrographis 1-3 part, Radix Angelicae Sinensis 5-10 part, Radix Puerariae 5-10 part, Fructus Mume 13-16 part, Herba Artemisiae Annuae 3-10 part, Fructus Aurantii Immaturus 8-13 part, Rhizoma Dioscoreae 3-5 part, Radix Paeoniae Alba 1-3 part, Rhizoma Chuanxiong 5-10 part, Fructus Jujubae 3-6 part, HERBA CIRSII 8-13 part, Radix Gentianae Macrophyllae 3-5 part, Fructus Schisandrae Chinensis 4-8 part.

3. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 12 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 16 parts, Radix Sophorae Flavescentis 3 parts, Carapax Trionycis 12 parts, Rhizoma Cimicifugae 12 parts, Herba Patriniae 10 parts, Ramulus Cinnamomi 9 parts, Fructus Crataegi 15 parts, Cortex Magnoliae Officinalis 15 parts, Flos Lonicerae 8 parts, Herba Leonuri 5 parts, Bulbus Fritillariae Uninbracteatae 3 parts, Caulis Spatholobi 14 parts, Rhizoma Paridis 9 parts, Fructus Momordicae 6 parts, Herba Portulacae 8 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 1 part, Radix Angelicae Sinensis 10 parts, Radix Puerariae 5 parts, Fructus Mume 16 parts, Herba Artemisiae Annuae 10 parts, Fructus Aurantii Immaturus 8 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 1 part, Rhizoma Chuanxiong 10 parts, 6 parts, Fructus Jujubae, HERBA CIRSII 8 parts, Radix Gentianae Macrophyllae 3 parts, Fructus Schisandrae Chinensis 4 parts.

4. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 20 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 10 parts, Radix Sophorae Flavescentis 8 parts, Carapax Trionycis 5 parts, Rhizoma Cimicifugae 17 parts, Herba Patriniae 12 parts, Ramulus Cinnamomi 4 parts, Fructus Crataegi 20 parts, Cortex Magnoliae Officinalis 10 parts, Flos Lonicerae 12 parts, Herba Leonuri 2 parts, Bulbus Fritillariae Uninbracteatae 7 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 15 parts, Fructus Momordicae 3 parts, Herba Portulacae 13 parts, Concha Ostreae (calcined) 3 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 5 parts, Radix Puerariae 10 parts, Fructus Mume 13 parts, Herba Artemisiae Annuae 3 parts, Fructus Aurantii Immaturus 13 parts, Rhizoma Dioscoreae 3 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 5 parts, 4 parts, Fructus Jujubae, HERBA CIRSII 10 parts, Radix Gentianae Macrophyllae 4 parts, Fructus Schisandrae Chinensis 5 parts.

5. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 13 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 11 parts, Radix Sophorae Flavescentis 4 parts, Carapax Trionycis 6 parts, Rhizoma Cimicifugae 13 parts, Herba Patriniae 7 parts, Ramulus Cinnamomi 5 parts, Fructus Crataegi 18 parts, Cortex Magnoliae Officinalis 11 parts, Flos Lonicerae 9 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 6 parts, Caulis Spatholobi 12 parts, Rhizoma Paridis 13 parts, Fructus Momordicae 4 parts, Herba Portulacae 9 parts, Concha Ostreae (calcined) 4 parts, Herba Andrographis 2 parts, Radix Angelicae Sinensis 6 parts, Radix Puerariae 6 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 5 parts, Fructus Aurantii Immaturus 10 parts, Rhizoma Dioscoreae 4 parts, the Radix Paeoniae Alba 2 parts, Rhizoma Chuanxiong 6 parts, 5 parts, Fructus Jujubae, HERBA CIRSII 12 parts, Radix Gentianae Macrophyllae 3 parts, Fructus Schisandrae Chinensis 6 parts.

6. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 17 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 15 parts, Radix Sophorae Flavescentis 7 parts, Carapax Trionycis 11 parts, Rhizoma Cimicifugae 16 parts, Herba Patriniae 8 parts, Ramulus Cinnamomi 8 parts, Fructus Crataegi 16 parts, Cortex Magnoliae Officinalis 14 parts, Flos Lonicerae 11 parts, Herba Leonuri 3 parts, Bulbus Fritillariae Uninbracteatae 5 parts, Caulis Spatholobi 13 parts, Rhizoma Paridis 14 parts, Fructus Momordicae 5 parts, Herba Portulacae 12 parts, Concha Ostreae (calcined) 3 parts, Herba Andrographis 1 part, Radix Angelicae Sinensis 10 parts, Radix Puerariae 9 parts, Fructus Mume 13 parts, Herba Artemisiae Annuae 7 parts, Fructus Aurantii Immaturus 11 parts, Rhizoma Dioscoreae 3 parts, the Radix Paeoniae Alba 1 part, Rhizoma Chuanxiong 10 parts, 4 parts, Fructus Jujubae, HERBA CIRSII 11 parts, Radix Gentianae Macrophyllae 4 parts, Fructus Schisandrae Chinensis 7 parts.

7. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 15 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 12 parts, Radix Sophorae Flavescentis 5 parts, Carapax Trionycis 9 parts, Rhizoma Cimicifugae 15 parts, Herba Patriniae 9 parts, Ramulus Cinnamomi 7 parts, Fructus Crataegi 19 parts, Cortex Magnoliae Officinalis 13 parts, Flos Lonicerae 10 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 4 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 11 parts, Fructus Momordicae 5 parts, Herba Portulacae 10 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 8 parts, Radix Puerariae 8 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 9 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 8 parts, 6 parts, Fructus Jujubae, HERBA CIRSII 9 parts, Radix Gentianae Macrophyllae 5 parts, Fructus Schisandrae Chinensis 7 parts.

8. the pharmaceutical composition for the treatment of post gynecologic operation low fever according to claim 1, it is characterized in that: crude drug composition and the parts by weight of making described pharmaceutical composition are: 19 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 14 parts, Radix Sophorae Flavescentis 6 parts, Carapax Trionycis 7 parts, Rhizoma Cimicifugae 14 parts, Herba Patriniae 9 parts, Ramulus Cinnamomi 6 parts, Fructus Crataegi 17 parts, Cortex Magnoliae Officinalis 13 parts, Flos Lonicerae 10 parts, Herba Leonuri 4 parts, Bulbus Fritillariae Uninbracteatae 4 parts, Caulis Spatholobi 11 parts, Rhizoma Paridis 11 parts, Fructus Momordicae 5 parts, Herba Portulacae 10 parts, Concha Ostreae (calcined) 5 parts, Herba Andrographis 3 parts, Radix Angelicae Sinensis 8 parts, Radix Puerariae 8 parts, Fructus Mume 14 parts, Herba Artemisiae Annuae 4 parts, Fructus Aurantii Immaturus 9 parts, Rhizoma Dioscoreae 5 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 8 parts, 3 parts, Fructus Jujubae, HERBA CIRSII 8 parts, Radix Gentianae Macrophyllae 5 parts, Fructus Schisandrae Chinensis 8 parts.

9. according to the pharmaceutical composition of the arbitrary described treatment post gynecologic operation low fever of claim 3-8, it is characterized in that, described pharmaceutical composition adopts following preparation steps:

(1) each medical material of components by weight percent in the arbitrary described pharmaceutical composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate, when being concentrated into 50-60 DEG C, relative density is the clear paste of 1.10-1.30;

(2), after the clear paste that step (1) is obtained being placed to room temperature, adding ethanol and make, containing amount of alcohol to percentage by weight 60-75%, to leave standstill 24-48 hour, get supernatant; Supernatant reclaims ethanol, and when being evaporated to 50-60 DEG C, relative density is the clear paste of 1.20-1.30, centrifugal under the rotating speed of 3000r/min subsequently; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(3) dry extract that step (2) is obtained is put into super micron mill and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, drying, granulate, can obtain granule; Or put into super micron mill after the dry extract drying obtained by step (2) and pulverize 1-2 hour, sieve, obtain 100-200 object micropowders, make powder; Or the dry extract that step (2) is obtained is put into super micron mill and pulverizes 1-2 hour, sieve, obtain 100-200 object micropowders, add appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or the dry extract that step (2) is obtained is put into super micron mill and pulverizes 1-2 hour, sieve, obtain 100-200 object micropowders, add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (2) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of pharmaceutical composition in treatment post gynecologic operation low fever medicine of the treatment post gynecologic operation low fever as described in as arbitrary in claim 1-9.