CN102000175A - Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hemorrhoids and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients in parts by weight: 10 to 25 parts of cimicifuga foetida, 8 to 16 parts of radix bupleuri, 10 to 20 parts of radix scutellariae, 4 to 10 parts of rhubarb, 4 to 10 parts of angelica, 2 to 8 parts of sanguisorba, 2 to 8 parts of glabrous sarcandra herb, 1 to 6 parts of yerbadetajo herba ecliptae and 1 to 6 parts of liquorice. The traditional Chinese medicine composition can be prepared into any one clinically acceptable oral medicine preparation according to the conventional preparation method of the traditional Chinese medicine preparation, has the effects of removing pathogenic heat from blood, stopping bleeding for convergence and activating blood circulation to dissipate blood stasis, can fast realize the hemostasis convergence on various haemorrhoids such as internal hemorrhoids, external hemorrhoids, mixed hemorrhoids and the like, has exact and reliable curative effect, treats both the secondary and primary symptoms, is safe in clinical application and has no any toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of hemorrhoid and preparation method thereof, belong to the treatment by Chinese herbs field of hemorrhoid.
Background technology
Human body rectum end mucosa down and under the anal canal skin venous plexus take place to expand and the formed soft vein of flexing group, be called hemorrhoid, have another name called hemorrhoid, blood stasis, hemorrhoid disease, haemorrhoids etc.Medical science indication hemorrhoid comprise internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, are the venous plexus generation varicose of anal orifice and rectal intestine bottom and anal mucosa and a kind of chronic disease of the one or more softish vein group that forms.Hemorrhoid comprise internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, are the venous plexus generation varicose of anal orifice and rectal intestine bottom and anal mucosa and a kind of chronic disease of the one or more softish vein group that forms.
Show that according to relevant reconnaissance information the sickness rate of anorectal disease is 59.1%, hemorrhoid account for 87.25% of all anal and intestinal diseases, and wherein common with internal hemorrhoid, account for 52.19% of all anal and intestinal diseases.The men and women all can fall ill, and women's sickness rate is 67%, and male's sickness rate is 53.9%; Any age all can fall ill, and wherein the people in 20-40 year comparatively more sees, and increases the weight of with advancing age and gradually, so saying of " ten people, nine hemorrhoid " arranged.
The method of treatment hemorrhoid has operative treatment and two kinds of methods of Drug therapy.Adopt operative treatment, the patient suffering is bigger, and certain sequela risk is arranged.At present, the Chinese patent medicine that is used for the treatment of hemorrhoid has a variety of, and these medicines all have certain therapeutical effect for hemorrhoid, but all in various degree exist slow, the defective such as curative effect is remarkable inadequately that takes effect, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention be overcome the medicine of existing treatment hemorrhoid existing take effect slow, curative effect inadequately significantly, defective such as side effect is big, the Chinese medicine composition of the treatment hemorrhoid that provide a kind of instant effect, determined curative effect, have no side effect;
Another technical problem to be solved by this invention provides a kind of method for preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of hemorrhoid comprises that each component of following weight portion is formed: Rhizoma Cimicifugae 10-25 part, Radix Bupleuri 8-16 part, Radix Scutellariae 10-20 part, Radix Et Rhizoma Rhei 4-10 part, Radix Angelicae Sinensis 4-10 part, Radix Sanguisorbae 2-8 part, Herba Sarcandrae 2-8 part, Herba Ecliptae 1-6 part and Radix Glycyrrhizae 1-6 part;
Preferably, the weight portion of each crude drug is: Rhizoma Cimicifugae 15-20 part, Radix Bupleuri 10-15 part, Radix Scutellariae 10-15 part, Radix Et Rhizoma Rhei 4-8 part, Radix Angelicae Sinensis 4-8 part, Radix Sanguisorbae 2-6 part, Herba Sarcandrae 4-8 part, Herba Ecliptae 1-4 part, Radix Glycyrrhizae 1-4 part;
Most preferred, the weight portion of each crude drug is: 18 parts of Rhizoma Cimicifugaes, 12 parts of Radix Bupleuri, 15 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 6 parts of Radix Sanguisorbaes, 6 parts of Herba Sarcandraes, 3 parts of Herba Ecliptaes, 3 parts in Radix Glycyrrhizae;
Chinese medicine composition of the present invention is based on the inventor to pathogenetic research of hemorrhoid deep layer and Therapeutic Principle thereof, simultaneously according to inventor clinical experience and pharmaceutical research achievement for many years, filter out clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, hemostasis astringent crude drug, form according to certain weight proportion prescription.
Rhizoma Cimicifugae: be the dry rhizome of the big SANYE Rhizoma Cimicifugae of ranunculaceae plant Cimicifuga heracleifolia Kom., Rhizoma Cimicifugae Cimicifuga dahurica (Turcz.) Maxim. of Xingan or Rhizoma Cimicifugae Cimicifugafoetida L..Property suffering, little sweet is slightly cold.Return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.Be used for headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome is sent out speckle; Proctoptosis, uterine prolapse.
Radix Bupleuri: nature and flavor: hardship, be slightly cold, return through: return Liver Channel, gallbladder meridian.Function: evacuate and bring down a fever the yang invigorating soothing liver-QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after the solarization, dry.Nature and flavor with return through hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, the hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Et Rhizoma Rhei: be the root and the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Nature and flavor: hardship, cold.Gui Jing: stomach warp; Large intestine channel; Liver Channel; Spleen channel; Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation;
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Meridian distribution of property and flavor is warm in nature, hides sweet, hot.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Sanguisorbae: Radix Sanguisorbae (formal name used at school: Radix Sanguisorbae) be the plant of Rosaceae burnet.Return through liver; Lung; Kidney; Large intestine channel.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing, skin ulcer is held back in detumescence
Herba Sarcandrae: be the Herb of gold chestnut orchid Herba Pileae Scriptae Sarcandra glabra (Thunb.) Nakai, nature and flavor slightly warm in nature, bitter in the mouth, suffering.Function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.Be used for pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor.
Herba Ecliptae: be the herb of dicotyledon medicine feverfew Eclipta prostrata.Removing heat from blood is arranged, hemostasis, the kidney invigorating, the effect of tonifying YIN.
Radix Glycyrrhizae: property is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
In order to reach the effect of better clearing away heat and cooling blood, can in above-mentioned Chinese medicine composition, add Radix Rehmanniae 6-15 part, Flos Lonicerae 6-15 part, Folium Callicarpae Formosanae 5-12 part, Rhizoma Coptidis 2-6 part, Radix Trichosanthis 2-6 part, Radix Asparagi 2-8 part, Herba Sarcandrae 2-8 part, Herba Polygoni Perfoliati 2-8 part, Herba Verbenae 1-6 part, Herba Portulacae 1-6 part, Herba Ecliptae 1-6 part, Mahonia fortunei (Lindl.) Fedde 1-6 part and Squama Manis 1-6 part; Wherein, the weight portion of each component more preferably: 3 parts of 12 parts in the Radix Rehmanniae, 12 parts of Flos Lonicerae, 9 parts of Folium Callicarpae Formosanae, Rhizoma Coptidis 2-6 part, 4 parts of Radix Trichosanthis, 6 parts of Radix Asparagis, 6 parts of Herba Sarcandraes, 6 parts of Herba Polygoni Perfoliati, Herba Verbenae 1-6 part, 3 parts of Herba Portulacaes, 3 parts of Herba Ecliptaes, 3 parts of Mahonia fortunei (Lindl.) Fedde and Squama Maniss.
The Radix Rehmanniae:, be used as medicine with tuber for goatweed bosom celebrating Radix Rehmanniae [Rehmannia glutinosa (Gaerin) Libosch.f.huelchingensis (Chao et Schih) Hsiao)].Have the clearing away heat and cooling blood effect and be used for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.
Flos Lonicerae (Caulis Lonicerae Japonicae): prescription name: Flos Lonicerae, Flos Lonicerae, two precious flowers, Flos Lonicerae; Meridian distribution of property and flavor: cold; Sweet, little hardship; GUIXIN, lung meridian; Function cures mainly: heat-clearing and toxic substances removing, dispelling wind collateral dredging.Be used for the epidemic febrile disease heating, sore and toxic, toxic-heat and blood stasis, rheumatism pyretic arthralgia.
Folium Callicarpae Formosanae:, be used as medicine with root and leaf for Herba Verbenae Callicarpa plant Folium Callicarpae Macrophyllae Callicarpa macrophylla Vahl.Nature and flavor with return through: hot, bitter, flat.Return liver, spleen, stomach warp; Function with cure mainly: dissipating blood stasis hemostasis, reducing swelling and alleviating pain.Leaf: be used for spitting blood, spitting of blood, epistaxis is had blood in stool; The external curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.
Radix Trichosanthis: be the root of cucurbitaceous plant Chinese juniper beach wormwood, be clearing away heat-fire class medicine, its effect is a clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.
Radix Asparagi: the tuber for liliaceous plant Radix Asparagi Asparaguscochinchinensis (Lour.) Merr. has another name called Radix Asparagi.Cold in nature, sweet in the mouth, little hardship.Has replenishing YIN and removing heat, the effect of lung moistening nourishing kidney.Be used to control fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst, disease such as constipation.
Herba Polygoni Perfoliati: the herb that passes through the leaf knotweed for the Polygonaceae platymiscium.It has removing blood stasis and replenishing blood, the effect of heat-clearing and toxic substances removing.
Herba Verbenae: be the aerial parts of Verenaceae plant Herba Verbenae Verbena officinalis L..Heat and toxic materials clearing away medicine; The promoting blood circulation to restore menstrual flow medicine; Edema-alleviating diuretic; The preventing the attack (or recurrence) of malaria medicine.
Herba Portulacae: also cry horse Herba Amaranthi tricoloris, five elements' grass, five FANGCAO, long life dish, Herba Peristrophes.Herba Portulacae has the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.
Mahonia fortunei (Lindl.) Fedde: be Berberidaceae Mahonia plant Mahonia bealei (Fort.) Carr. Mahonia bealei (Fort.) Carr. and narrow leaf Mahonia fortunei (Lindl.) Fedde M.fortunei (Lindl) Fedde.Be used as medicine with root, stem, leaf.Leaf: nourishing YIN and clearing away heat.Cure mainly pulmonary tuberculosis, flu.Root, stem: heat-clearing and toxic substances removing.Cure mainly bacillary dysentery, acute smooth gastritis, infectious hepatitis, pneumonia, pulmonary tuberculosis, bronchitis, laryngopharynx swelling and pain.Eye conjunctivitis is controlled in external, carbuncle furuncle and phyma poison, burn.
Squama Manis: be the scale of Manidae animal Manitis.Effect: blood circulation promoting and dispersing pathogen accumulation; The stimulating milk secretion of stimulating the menstrual flow; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle; Scrofula.
In order to reach better hemostasis astringent effect, can in above-mentioned Chinese medicine composition, add Rhizoma Imperatae 5-15 part, Radix Rubiae 4-12 part, Herba Agrimoniae 4-12 part, Flos Sophorae 4-12 part, Radix Paeoniae Alba 2-8 part, Xiao Thistle 2-8 part, Galla Chinensis 2-8 part and Pseudobulbus Bletillae (Rhizoma Bletillae) 2-8 part; Preferred, the weight portion of each component is: 6 parts of 12 parts of Rhizoma Imperataes, 10 parts in Radix Rubiae, 10 parts of Herba Agrimoniaes, 10 parts in Flos Sophorae, 6 parts of 6 parts of, Xiao of Radix Paeoniae Alba Thistle, 6 parts of Galla Chinensiss and the Pseudobulbus Bletillae (Rhizoma Bletillae)s;
Rhizoma Imperatae: have another name called Rhizoma Imperatae, Rhizoma Imperatae, Rhizoma Imperatae, for the grass family Rhizoma Imperatae belongs to herbaceos perennial.Removing heat from blood, hemostasis, heat clearing away, diuresis.Control the calentura excessive thirst, spit blood epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.
Radix Rubiae: this product is the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling.
Herba Agrimoniae: the overground part of Verenaceae plant; Formal name used at school: Agrimonia eupatoria.Astringing to arrest bleeding has heart tonifying, rises blood pressure, blood coagulation, hemostasis, removing heat from blood, effect such as antibiotic.
Flos Sophorae: effect with heat-clearing and toxic substances removing, removing heat from blood lung moistening, blood pressure lowering, prevention of stroke.
Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Xiao Thistle: be the aerial parts of feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..Function with cure mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.Be used for epistaxis, spit blood, hematuria is had blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Galla Chinensis: go up the insect gall that forms behind parasitic times Aphidiadae insecticide Chinese Nut-gall aphid or the melaphis peitan Tsai et Tang for Anacardiaceae plant Fructus rhois chinensis (Rhus chinensis Mill.), blue or green bran poplar (R.potaninii Maxim.) and Radix Rhois Sinicae trees such as (R.punjabensis Stewardvar.sinica (Diels) Rehd.et Wils.).Meridian distribution of property and flavor: sour in the mouth is puckery, cold in nature.Return lung, large intestine, kidney channel.Effect: astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Detoxifcation.
The Pseudobulbus Bletillae (Rhizoma Bletillae): have another name called Rhizoma Bletillae, luxuriant tongue orchid, Lian Jicao; Effect: astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
In order to reach the effect of better blood circulation promoting and blood stasis dispelling, can in above-mentioned Chinese medicine composition, add Radix Paeoniae Rubra 6-12 part, Radix Notoginseng 6-12 part and Semen Persicae 2-8 part; Preferred, the weight portion of each component is: 5 parts in 9 parts of Radix Paeoniae Rubra, 9 parts of Radix Notoginseng and Semen Persicae;
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeoniaveitchii Lynch.The property hardship is slightly cold.Return Liver Channel.Function cures mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.
Radix Notoginseng: nature and flavor: warm in nature, sweet in the mouth, little hardship.Function cures mainly: dissipating blood stasis hemostasis, subduing swelling and relieving pain.Be used for various inside and outside hemorrhage, breast ventral spine pain, tumbling and swelling.
Semen Persicae: another name Radix Fici Hirtae core, almond core, big Semen Persicae.Seed for Folium rosae multiflorae plant peach prunuspersicabatsch.Function cures mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
In order to reach the effect of moistening dryness for relaxing bowels, can in above-mentioned Chinese medicine composition, add Fructus Cannabis 4-10 part, Cortex Magnoliae Officinalis 4-10 part, Fructus Aurantii 2-8 part, Radix Scrophulariae 2-8 part and Radix Ophiopogonis 2-8 part; Preferred, the weight portion of each component is: 5 parts of 8 parts of Fructus Cannabiss, 8 parts of Cortex Magnoliae Officinalis, 5 parts of Fructus Aurantiis, 5 parts of Radix Scrophulariae and Radix Ophiopogonis.
Fructus Cannabis: Fructus Cannabis is the dry mature seed of moraceae plants Fructus Cannabis (Cannabis sativa L.), and another name is cannabis,fructus, Urtica cannabina L., hemp again.Urtica cannabina L. has cultivation in the most of area of China, and happiness warm and moist weather is not tight to the soil requirement, and deep with soil layer, loose fertile, well-drained sand paper soil or clayey soil are advisable.Gather during fruit maturation autumn, removes impurity, dries the back and be Fructus Cannabis.The Fructus Cannabis sweet in the mouth, property is flat, returns spleen, stomach, large intestine channel, the effect loosening bowel to relieve constipation, moisturizes parasite killing.
Fructus Aurantii: Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.The nature and flavor hardship; Acid; Cold nature is returned through lung; Spleen; Liver; Stomach; The large intestine channel function cures mainly: the septum pectorale feeling of fullness; Distending pain over the hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Distension and fullness in the abdomen; Heavy behind the dysentery; Proctoptosis; Uterine prolapse.
Radix Scrophulariae: Radix Scrophulariae is the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae.Another name: Radix Scrophulariae, Zhejiang Radix Scrophulariae, black ginseng, black Radix Scrophulariae.Bitter in the mouth is salty.Cold nature.Nontoxic.Cure mainly: main pathogenic cold in abdomen heat localization.
Each medicine compatibility is played the effect of clearing away heat and cooling blood, hemostasis convergence, blood circulation promoting and blood stasis dispelling together altogether among the side of the present invention, Chinese medicine composition of the present invention is for the hemorrhoid treating both the principal and secondary aspects of a disease of various cards, clinical observation on the therapeutic effect confirms, for the convergence of all stopping blooding rapidly of various pattern of syndrome hemorrhoid such as internal hemorrhoid, external hemorrhoid and mixed hemorrhoid, determined curative effect is reliable, true.Chinese medicine composition of the present invention is nontoxic, and is safe and reliable, has no adverse reaction after taking, clinical safe in utilization.
The material medicine of respectively distinguishing the flavor of that the present invention is used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any suitable clinical preparation, for example can be pill, powder, granule, capsule, tablet, oral liquid or drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after each crude drug of the present invention taken by weighing by described weight portion proportioning, pulverize, sieve (for example can be the 400-1000 mesh sieve), promptly.Certainly, after also each crude drug can being pulverized, add required adjuvant or the excipient of preparations shaping, be prepared into capsule, tablet or pill according to conventional method.
The another kind of preparation method of Chinese medicine composition of the present invention: take by weighing each crude drug by described weight portion; Each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds the adjuvant or the excipient of preparations shaping, preparations shaping, promptly.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on factors such as concrete dosage form, patient's age, health status.As guidance: usage and dosage: capsule, each capsule content 0.6 gram crude drug, each oral 8 to 12, three times on the one, 3 days is a course of treatment.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment; these embodiment only are exemplary; what those skilled in the art should understand that is; down can make amendment or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention the details of technical solution of the present invention and form.
The preparation of embodiment 1 capsule
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 180, Radix Bupleuri 120, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 60, Herba Ecliptae 30, Radix Glycyrrhizae 30 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 2 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 150, Radix Bupleuri 100, Radix Scutellariae 100, Radix Et Rhizoma Rhei 40, Radix Angelicae Sinensis 40, Radix Sanguisorbae 20, Herba Sarcandrae 40, Herba Ecliptae 10, Radix Glycyrrhizae 10 by following weight; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 3 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 200, Radix Bupleuri 150, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 80, Herba Ecliptae 40, Radix Glycyrrhizae 40 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 6 times of weight of water for the first time, decocted 2 hours, add 4 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 4 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 100, Radix Bupleuri 80, Radix Scutellariae 100, Radix Et Rhizoma Rhei 40, Radix Angelicae Sinensis 40, Radix Sanguisorbae 20, Herba Sarcandrae 20, Herba Ecliptae 10, Radix Glycyrrhizae 10 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 5 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 250, Radix Bupleuri 160, Radix Scutellariae 200, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Herba Sarcandrae 80, Herba Ecliptae 60, Radix Glycyrrhizae 60 by following weight; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 6 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 180 by following weight, Radix Bupleuri 120, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 60, Herba Ecliptae 30, Radix Glycyrrhizae 30, the Radix Rehmanniae 60, Flos Lonicerae 60, Folium Callicarpae Formosanae 50, Rhizoma Coptidis 20, Radix Trichosanthis 20, Radix Asparagi 20, Herba Polygoni Perfoliati 20, Herba Verbenae 10, Herba Portulacae 10, Mahonia fortunei (Lindl.) Fedde 10, Squama Manis 10; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 7 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 250 by following weight, Radix Bupleuri 160, Radix Scutellariae 200, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Radix Glycyrrhizae 60, the Radix Rehmanniae 150, Flos Lonicerae 150, Folium Callicarpae Formosanae 120, Rhizoma Coptidis 60, Radix Trichosanthis 60, Radix Asparagi 80, Herba Polygoni Perfoliati 80, Herba Verbenae 60, Herba Portulacae 60, Mahonia fortunei (Lindl.) Fedde 60 and Squama Manis 60; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 8 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 180, Radix Bupleuri 120, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80 by following weight, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 60, Herba Ecliptae 30, Radix Glycyrrhizae 30, Rhizoma Imperatae 50, Radix Rubiae 40, Herba Agrimoniae 40, Flos Sophorae 40, Radix Paeoniae Alba 20, Xiao Thistle 20, Galla Chinensis 20 and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 9 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 250, Radix Bupleuri 160, Radix Scutellariae 200 by following weight, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Radix Glycyrrhizae 60, Rhizoma Imperatae 150, Radix Rubiae 120, Herba Agrimoniae 120, Flos Sophorae 120, Radix Paeoniae Alba 80, Xiao Thistle 80, Galla Chinensis 80 and the Pseudobulbus Bletillae (Rhizoma Bletillae) 80; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 10 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 180, Radix Bupleuri 120, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 60, Herba Ecliptae 30, Radix Glycyrrhizae 30, Radix Paeoniae Rubra 60, Radix Notoginseng 60 and Semen Persicae 20 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 11 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 250, Radix Bupleuri 160, Radix Scutellariae 200, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Radix Glycyrrhizae 60, Radix Paeoniae Rubra 120, Radix Notoginseng 120 and Semen Persicae 80 by following weight; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 12 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 180, Radix Bupleuri 120, Radix Scutellariae 150, Radix Et Rhizoma Rhei 80, Radix Angelicae Sinensis 80, Radix Sanguisorbae 60, Herba Sarcandrae 60, Herba Ecliptae 30, Radix Glycyrrhizae 30, Fructus Cannabis 40, Cortex Magnoliae Officinalis 40, Fructus Aurantii 20, Radix Scrophulariae 20 and Radix Ophiopogonis 20 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add ethanol and make granule in right amount, drying, granulate, filled capsules, promptly.
The preparation of embodiment 13 capsules
Take by weighing each crude drug (unit: g): Rhizoma Cimicifugae 250, Radix Bupleuri 160, Radix Scutellariae 200, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Radix Glycyrrhizae 60, Fructus Cannabis 100, Cortex Magnoliae Officinalis 100, Fructus Aurantii 80, Radix Scrophulariae 80 and Radix Ophiopogonis 80 by following weight; Above-mentioned each crude drug is pulverized the back cross 800 mesh sieves, filled capsules, promptly.
The preparation of embodiment 14 tablets
Take by weighing each raw material (unit: g): Rhizoma Cimicifugae 100 by following weight, Radix Bupleuri 80, Radix Scutellariae 100, Radix Et Rhizoma Rhei 40, Radix Angelicae Sinensis 40, Radix Sanguisorbae 20, Radix Glycyrrhizae 10, the Radix Rehmanniae 60, Flos Lonicerae 60, Folium Callicarpae Formosanae 50, Rhizoma Coptidis 20, Radix Trichosanthis 20, Radix Asparagi 20, Herba Sarcandrae 20, Herba Polygoni Perfoliati 20, Herba Verbenae 10, Herba Portulacae 10, Herba Ecliptae 10, Mahonia fortunei (Lindl.) Fedde 10, Squama Manis 10; After each crude drug mixing, add 6 times of weight decoctings of water and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Filtrate decompression is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃), and spray drying was pulverized 120 mesh sieves, adds dextrin, granulation, dry, granulate, and tabletting, coating is made tablet, promptly.
The preparation of embodiment 15 oral liquids
Take by weighing each raw material (unit: g): Rhizoma Cimicifugae 250 by following weight, Radix Bupleuri 160, Radix Scutellariae 200, Radix Et Rhizoma Rhei 100, Radix Angelicae Sinensis 100, Radix Sanguisorbae 80, Radix Glycyrrhizae 60, the Radix Rehmanniae 150, Flos Lonicerae 150, Folium Callicarpae Formosanae 120, Rhizoma Coptidis 60, Radix Trichosanthis 60, Radix Asparagi 80, Herba Sarcandrae 80, Herba Polygoni Perfoliati 80, Herba Verbenae 60, Herba Portulacae 60, Herba Ecliptae 60, Mahonia fortunei (Lindl.) Fedde 60 and Squama Manis 60; After each crude drug mixing, add 6 times of weight decoctings and boil 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction left standstill, and filtered; Add ethanol in the filtrate and make and contain the alcohol amount and reach 70-80%, left standstill 24 hours, get supernatant, add syrup after, add water to 10000ml, filter, fill, sterilization, promptly.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating hemorrhoid of the present invention
One, physical data: observe 275 examples altogether, women's 142 examples wherein, male's 133 examples, 34 years old mean age; Wherein internal hemorrhoid patient 87 examples, external hemorrhoid patient's 98 examples, mixed hemorrhoid patient's 90 examples;
Two, trial drug
Embodiment of the invention 1-15 drug prepared.
Three, Therapeutic Method
275 routine patients are divided into 5 groups at random, that is: test 1 group, 2 groups of tests, 3 groups of tests, test 4 groups and test 5 groups, every group of each 55 example are tested 1 group and are adopted the prepared capsule treatment of embodiment 1, test 2 groups and adopt the prepared capsules treatment of embodiment 6; Test 3 groups and adopt embodiment 8 prepared capsules to treat, test 4 groups and adopt embodiment 10 prepared capsules to treat; Testing 5 groups adopts embodiment 12 prepared capsules to treat; Oral, one time 8 (0.6g crude drug/grain), 3 times on the one, 3 days is a course of treatment, treats 2 courses of treatment altogether; Period in a medicine is withdrawn other related drugs and other treatment.
Four, efficacy assessment standard
Efficacy assessment standard and foundation: (1) clinical recovery: clinical symptom disappearance, Signs integration reduce 〉=95%; (2) produce effects: clinical symptoms obviously alleviates, and the Signs integration reduces 70-90%; (3) effective: clinical symptoms takes a turn for the better to some extent, and the Signs integration reduces 40-70%; (4) invalid: the clinical symptoms no change, the Signs integration reduces≤50%;
Five, clinical observation result
Clinical observation result sees Table 1.
The clinical observation on the therapeutic effect result of the test of the various hemorrhoid of table 1 traditional Chinese medicine composition for treating of the present invention
Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention has significant curative effect for various hemorrhoid patients; Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (10)
1. a Chinese medicine composition for the treatment of hemorrhoid is characterized in that, comprises that the component of following weight portion is formed: Rhizoma Cimicifugae 10-25 part, Radix Bupleuri 8-16 part, Radix Scutellariae 10-20 part, Radix Et Rhizoma Rhei 4-10 part, Radix Angelicae Sinensis 4-10 part, Radix Sanguisorbae 2-8 part, Herba Sarcandrae 2-8 part, Herba Ecliptae 1-6 part and Radix Glycyrrhizae 1-6 part.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight portion of each component is: Rhizoma Cimicifugae 15-20 part, Radix Bupleuri 10-15 part, Radix Scutellariae 10-15 part, Radix Et Rhizoma Rhei 4-8 part, Radix Angelicae Sinensis 4-8 part, Radix Sanguisorbae 2-6 part, Herba Sarcandrae 4-8 part, Herba Ecliptae 1-4 part, Radix Glycyrrhizae 1-4 part.
3. according to claim 1 or 2 described Chinese medicine compositions, it is characterized in that the weight portion of each component is: 18 parts of Rhizoma Cimicifugaes, 12 parts of Radix Bupleuri, 15 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Radix Angelicae Sinensis, 6 parts of Radix Sanguisorbaes, 6 parts of Herba Sarcandraes, 3 parts of Herba Ecliptaes, 3 parts in Radix Glycyrrhizae.
4. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that, also contain: Radix Rehmanniae 6-15 part, Flos Lonicerae 6-15 part, Folium Callicarpae Formosanae 5-12 part, Rhizoma Coptidis 2-6 part, Radix Trichosanthis 2-6 part, Radix Asparagi 2-8 part, Herba Polygoni Perfoliati 2-8 part, Herba Verbenae 1-6 part, Herba Portulacae 1-6 part, Mahonia fortunei (Lindl.) Fedde 1-6 part and Squama Manis 1-6 part; Preferably, the weight portion of each component is: 3 parts of 12 parts in the Radix Rehmanniae, 12 parts of Flos Lonicerae, 9 parts of Folium Callicarpae Formosanae, Rhizoma Coptidis 2-6 part, 4 parts of Radix Trichosanthis, 6 parts of Radix Asparagis, 6 parts of Herba Polygoni Perfoliati, Herba Verbenae 1-6 part, 3 parts of Herba Portulacaes, 3 parts of Mahonia fortunei (Lindl.) Fedde and Squama Maniss.
5. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that, also contain: Rhizoma Imperatae 5-15 part, Radix Rubiae 4-12 part, Herba Agrimoniae 4-12 part, Flos Sophorae 4-12 part, Radix Paeoniae Alba 2-8 part, Xiao Thistle 2-8 part, Galla Chinensis 2-8 part and Pseudobulbus Bletillae (Rhizoma Bletillae) 2-8 part; Preferably, the weight portion of each component is: 6 parts of 12 parts of Rhizoma Imperataes, 10 parts in Radix Rubiae, 10 parts of Herba Agrimoniaes, 10 parts in Flos Sophorae, 6 parts of 6 parts of, Xiao of Radix Paeoniae Alba Thistle, 6 parts of Galla Chinensiss and the Pseudobulbus Bletillae (Rhizoma Bletillae)s.
6. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that, also contain: Radix Paeoniae Rubra 6-12 part, Radix Notoginseng 6-12 part and Semen Persicae 2-8 part; Preferably, the weight portion of each component is: 5 parts in 9 parts of Radix Paeoniae Rubra, 9 parts of Radix Notoginseng and Semen Persicae.
7. according to any one described Chinese medicine composition of claim 1-3, it is characterized in that, also contain: Fructus Cannabis 4-10 part, Cortex Magnoliae Officinalis 4-10 part, Fructus Aurantii 2-8 part, Radix Scrophulariae 2-8 part and Radix Ophiopogonis 2-8 part; Preferably, the weight portion of each component is: 5 parts of 8 parts of Fructus Cannabiss, 8 parts of Cortex Magnoliae Officinalis, 5 parts of Fructus Aurantiis, 5 parts of Radix Scrophulariae and Radix Ophiopogonis.
8. according to any one described Chinese medicine composition of claim 1-7, it is characterized in that: it is prepared into any acceptable clinically oral drug preparation; Preferably, described oral drug preparation is pill, powder, granule, capsule, tablet, drop pill or oral liquid.
9. method for preparing any one described Chinese medicine composition of claim 1-7 may further comprise the steps:
(1), takes by weighing each crude drug by described weight proportion;
(2) each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds the adjuvant or the excipient of preparations shaping, preparations shaping, promptly.
10. the purposes of any one described Chinese medicine composition of claim 1-7 in preparation antihaemorrhoidals thing.
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Cited By (9)
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| CN102579690A (en) * | 2012-03-02 | 2012-07-18 | 陈电云 | Blood circulation promoting hemorrhoids ointment |
| CN103055132A (en) * | 2011-10-18 | 2013-04-24 | 王维德 | Drug for treating anorectal diseases |
| CN103432497A (en) * | 2013-09-10 | 2013-12-11 | 于浩 | External preparation for treating haemorrhoids |
| CN103463449A (en) * | 2013-10-11 | 2013-12-25 | 雷会勇 | Traditional Chinese medicine composite used for treating haemorrhoids and preparation method and application thereof |
| CN103830427A (en) * | 2014-03-01 | 2014-06-04 | 朱素华 | Drug for treating haemorrhoids and preparation method thereof |
| CN104705461A (en) * | 2015-04-15 | 2015-06-17 | 曾盛钊 | Traditional Chinese medicine herbal tea bag capable of treating haemorrhoids |
| CN105521332A (en) * | 2015-12-26 | 2016-04-27 | 黄文珍 | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof |
| CN105983020A (en) * | 2015-02-09 | 2016-10-05 | 青岛申达高新技术开发有限公司 | Pharmaceutical composition for treating inflammatory external hemorrhoids and application of pharmaceutical composition |
| CN108186766A (en) * | 2018-01-19 | 2018-06-22 | 范鹏程 | For treating the Chinese medicine composition of hemorrhoid |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103055132A (en) * | 2011-10-18 | 2013-04-24 | 王维德 | Drug for treating anorectal diseases |
| CN102579690A (en) * | 2012-03-02 | 2012-07-18 | 陈电云 | Blood circulation promoting hemorrhoids ointment |
| CN102579690B (en) * | 2012-03-02 | 2013-07-31 | 陈电云 | Blood circulation promoting hemorrhoids ointment |
| CN103432497A (en) * | 2013-09-10 | 2013-12-11 | 于浩 | External preparation for treating haemorrhoids |
| CN103432497B (en) * | 2013-09-10 | 2015-05-20 | 李健 | External preparation for treating haemorrhoids |
| CN103463449A (en) * | 2013-10-11 | 2013-12-25 | 雷会勇 | Traditional Chinese medicine composite used for treating haemorrhoids and preparation method and application thereof |
| CN103830427A (en) * | 2014-03-01 | 2014-06-04 | 朱素华 | Drug for treating haemorrhoids and preparation method thereof |
| CN105983020A (en) * | 2015-02-09 | 2016-10-05 | 青岛申达高新技术开发有限公司 | Pharmaceutical composition for treating inflammatory external hemorrhoids and application of pharmaceutical composition |
| CN104705461A (en) * | 2015-04-15 | 2015-06-17 | 曾盛钊 | Traditional Chinese medicine herbal tea bag capable of treating haemorrhoids |
| CN105521332A (en) * | 2015-12-26 | 2016-04-27 | 黄文珍 | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof |
| CN108186766A (en) * | 2018-01-19 | 2018-06-22 | 范鹏程 | For treating the Chinese medicine composition of hemorrhoid |
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| CN102000175B (en) | 2012-11-14 |
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