CN103432497A - External preparation for treating haemorrhoids - Google Patents
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- CN103432497A CN103432497A CN2013104079200A CN201310407920A CN103432497A CN 103432497 A CN103432497 A CN 103432497A CN 2013104079200 A CN2013104079200 A CN 2013104079200A CN 201310407920 A CN201310407920 A CN 201310407920A CN 103432497 A CN103432497 A CN 103432497A
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external preparation for treating haemorrhoids. The external preparation comprises active ingredients and auxiliary materials acceptable in pharmaceutical science, wherein the active ingredients are prepared through water extract and alcohol precipitate by the following traditional Chinese medicinal materials in parts by weight: 8-13 parts of sanguisorba officinalis, 8-13 parts of honeysuckle, 8-13 parts of radix stemonae, 10-18 parts of ligusticum wallichii, 10-18 parts of sophora flower, 10-18 parts of agrimonia pilosa, 10-18 parts of purslane, 25-35 parts of burdock, and 25-35 parts of cortex dictamni. Through combined actions of stopping blood, improving microcirculation, diminishing inflammation and easing pain, the external preparation can treat the haemorrhoids once and for all.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of pharmaceutical composition for the treatment of hemorrhoid, relate in particular to a kind of external preparation for the treatment of hemorrhoid.
Background technology
Hemorrhoid are a kind of common property, multiple characteristic of disease anal and intestinal disease, hemorrhoid be under the rectum end mucosa and anal canal skin under venous plexus expansion and the formed soft vein agglomerate of flexing occur, main clinical manifestation for having blood in stool, pain, edema, falling inflation, pruritus, secretions increase and the symptom such as deviate from, relevant research shows, the sickness rate of China's hemorrhoid is about 46%, reach 70% in some district, sickness rate American-European, Japanese data survey is about 40%-60%.Many patients, because hemorrhoid occur having blood in stool, deviate from and the symptoms such as pain, have had a strong impact on life, working and learning, so there is the exploitation of the hemorrhoid treating medicine of good result to have great importance.
The method for the treatment of hemorrhoid mainly contains Drug therapy, surgical ligation and injection treatment at present.China anorectal educational circles has held the sick symposium of national hemorrhoid in April, 2000 in Chengdu, in new definition to hemorrhoid, explicitly point out " purpose of all treatments is not to eliminate the hemorrhoid body; but eliminate symptom; and the symptom of removing hemorrhoid is more meaningful than changing hemorrhoid body size, should be considered the standard of therapeutic effect ".These new treatment theories make the Therapeutic Principle of hemorrhoid clear, and the importance of the especially basic Drug therapy of non-operative treatment is appeared suddenly.Now mostly scholar's suggestion is that hemorrhoid patients more than ninety percent can adopt non-operative treatment, only less than 10% hemorrhoid patients, needs surgical intervention.Reason is Drug therapy energy reducing swelling and alleviating pain, relief of symptoms, has avoided again the pain of operation and the complication of injection treatment, so most people is applicable to Drug therapy.At present the medicine for hemorrhoid mainly contains antibiotics, hemorrhage and Chinese patent medicine, front two class medicines often take stopgap measures refractory this, the recurrence probability is large, of long duration often can worsen.In addition, drug treatment takes for oral administration or topical patch to need systemic Absorption treatment relieving constipation medicine in addition clinically at present, this class drug main will rely on softening stool, reduce the impact of stool to the anus blood stasis during defecation, thereby alleviate the misery of hemorrhoid patients, but this class medicine does not change the basic state of an illness of hemorrhoid patients and does not change in other words conj.or perhaps the cause of disease, and in fact the state of an illness is among development.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide a kind of external used medicine that there is antiinflammatory, analgesia, hemostasis, improves the treatment hemorrhoid of vascular permeability effect.
In order to realize purpose of the present invention, the inventor studies by lot of experiments, has finally obtained following technical scheme:
A kind of external preparation for the treatment of hemorrhoid, comprise active component and pharmaceutically acceptable adjuvant, described active component is prepared from through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion: Radix Sanguisorbae 8-13 part, Flos Lonicerae 8-13 part, Radix Stemonae 8-13 part, Rhizoma Chuanxiong 10-18 part, Flos Sophorae 10-18 part, Herba Agrimoniae 10-18 part, Herba portulacae 10-18 part, Fructus Arctii 25-35 part, Cortex Dictamni 25-35 part.
The external preparation for the treatment of hemorrhoid of the present invention, the traditional Chinese medicinal material raw materials that active component wherein is preferably by following weight portion is prepared from through water extract-alcohol precipitation: 10 parts of Radix Sanguisorbaes, 10 parts of Flos Loniceraes, 10 parts of the Radixs Stemonae, 14 parts of Rhizoma Chuanxiongs, 14 parts, Flos Sophorae, 14 parts of Herba Agrimoniaes, 14 parts of Herba portulacaes, 30 parts of Fructus Arctiis, 30 parts of Cortex Dictamni.
The external preparation of above-mentioned treatment hemorrhoid can be prepared into gel, ointment, suppository or ointment.
Further preferably, when the external preparation of above-mentioned treatment hemorrhoid is prepared into gel, wherein said pharmaceutically acceptable adjuvant is selected from the two or more of carbomer, propylene glycol, glycerol, triethanolamine and cellulose derivative.
Further preferably, when the external preparation of above-mentioned treatment hemorrhoid is prepared into ointment, wherein said pharmaceutically acceptable adjuvant is selected from two or more in glyceryl monostearate, glycerol, propylene glycol, stearic acid, white vaseline, triethanolamine, sodium lauryl sulphate and ethyl hydroxybenzoate.
Further preferably, when the external preparation of above-mentioned treatment hemorrhoid is prepared into suppository, wherein said pharmaceutically acceptable adjuvant is selected from two or more in semi-synthetic fatty glyceride, glycerol, gelatin and Polyethylene Glycol.
Further preferably, when the external preparation of above-mentioned treatment hemorrhoid is prepared into ointment, wherein said pharmaceutically acceptable adjuvant is selected from two or more in glyceryl monostearate, paraffin, white vaseline, liquid paraffin, propylene glycol, P-hydroxybenzoic acid second and sorbester p17.
It should be noted that, according to the Chinese medicine Historical Data Data About, the selected Chinese crude drug of the present invention has following function and cures mainly and originate:
Radix Sanguisorbae: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Spit blood, spitting of blood, epistaxis, hematuria, have blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.Select the dry root of rosaceous plant Radix Sanguisorbae Sanguisorba officinalis L..
Flos Lonicerae: heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multi-infection disease.Be selected from the dry flower of caprifoliaceae plant Radix Ophiopogonis (Lonicera japonica Thunb).
The Radix Stemonae: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.For new chronic cough, cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.Be selected from the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq..
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Select the rhizome of samphire Rhizoma Chuanxiong.
Flos Sophorae: cooling blood for hemostasis; Liver heat removing and eyesight improving.Main discharging fresh blood stool; The hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; The liver-heat headache; Conjunctival congestion and swelling pain; The carbuncle skin infection.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, the liver-heat conjunctival congestion, have a headache dizzy.
Herba Agrimoniae: astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.
Herba portulacae: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Select the young young stem and leaf of portulacaceous plant Herba Portulacae.
Fructus Arctii: there is the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule not thoroughly, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Cortex Dictamni: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Cure mainly the rubella due to the wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.Select the root bark of rutaceae shaggy-fruited dittany and Dictamnus angustifolius.
By the preparation technology of above-mentioned each traditional Chinese medicinal material raw materials preparation cost invention external preparation, be: take the mixing of Radix Sanguisorbae 8-13 part, Flos Lonicerae 8-13 part, Radix Stemonae 8-13 part, Rhizoma Chuanxiong 10-18 part, Flos Sophorae 10-18 part, Herba Agrimoniae 10-18 part, Herba portulacae 10-18 part, Fructus Arctii 25-35 part and Cortex Dictamni 25-35 part, add the water that 10-12 doubly measures, soak 12h-16h, then decoct three times, decoct for the first time 1.5-2h, leach medicinal liquid stand-by, the water that adds for the second time 8-10 doubly to measure, decoct 1-1.5h, leaches medicinal liquid stand-by, the water that adds for the third time 6-8 doubly to measure, decoct 0.8-1h, leaches medicinal liquid stand-by, merge three times decocting liquid, filter, collect filtrate, 0.07MPa, the extractum that while under 60-70 ℃, being evaporated to 65 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing the alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, relative density when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃ (water relatively) is 1.25 left and right, and recovery ethanol, obtain concentrated solution, by the concentrated solution spray drying, (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain the clear paste powder; Clear paste powder and pharmaceutically acceptable adjuvant are prepared into to gel, ointment, suppository or ointment according to common process.
Chinese medicine for external application provided by the present invention reaches the effect of radical cure hemorrhoid by the comprehensive functions such as microcirculation, antiinflammatory, analgesia of stopping blooding, improve, be applicable to the intractable hemorrhoid for the treatment of, especially is applicable to treating the hemorrhagic hemorrhoid.By animal experiment study, find, Chinese medicine for external application of the present invention can suppress the auris dextra swelling of caused by dimethylbenzene xylene inflammation mouse model, reduce the rectum vein permeability of Oleum Tiglii hemorrhoid rat model, analgesic effect is also more remarkable simultaneously, and the first-line drug that can be used as hemorrhoid treating is developed.In addition, formula of the present invention not only can bring into play the effect separately of component, can embody again the cooperative effect of said components, promotes mutually to absorb, and strengthened the therapeutic effect of hemorrhoid.
Specific embodiment
We find in screening experiment, and in pharmaceutical composition of the present invention, the consumption of every kind of traditional Chinese medicinal material raw materials slightly changes among a small circle, and it all has the biological activity for the treatment of hemorrhoid.Now by following embodiment, further illustrate pharmaceutical composition of the present invention and preparation method thereof and therapeutic effect, but protection scope of the present invention is not limited to embodiment.
The preparation of embodiment 1 Chinese medicine clear paste powder
Take 10 parts of Radix Sanguisorbaes, 10 parts of Flos Loniceraes, 10 parts of the Radixs Stemonae, 14 parts of Rhizoma Chuanxiongs, 14 parts, Flos Sophorae, 14 parts of Herba Agrimoniaes, 14 parts of Herba portulacaes, 30 parts of Fructus Arctiis and 30 parts of mixing of Cortex Dictamni, the water that adds 12 times of amounts, soak 12h-16h, then decocts three times, decoct for the first time 1.5-2h, leach medicinal liquid stand-by; The water that adds for the second time 10 times of amounts, decoct 1-1.5h, leaches medicinal liquid stand-by; The water that adds for the third time 8 times of amounts, decoct 0.8-1h, leaches medicinal liquid stand-by; Merge three times decocting liquid, filter, collect filtrate, 0.07MPa, extractum that while being evaporated to 65 ℃ under 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing the alcohol amount, stir, standing 24 hours, filter, relative density when filtrate concentrating under reduced pressure under 0.07MPa, 65 ℃ of conditions becomes to 65 ℃ (water relatively) is 1.25 left and right, and recovery ethanol, obtain concentrated solution, by the concentrated solution spray drying, (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain the clear paste powder.
The preparation of embodiment 2 Chinese medicine gel
Chinese medicine clear paste powder 20g
Carbomer 15g
Propylene glycol 75ml
Glycerol 75ml
Triethanolamine is appropriate
Purified water adds to 1000ml
Preparation technology: carbomer is slowly joined in the water of recipe quantity 50% left and right, the limit edged stirs until form transparent gel-type vehicle, the Chinese medicine clear paste powder of embodiment 1 preparation is dissolved in suitable quantity of water, add again in substrate, stir, add propylene glycol, glycerol, purified water to full dose, triethanolamine is regulated pH value to neutral, obtains.
The preparation of embodiment 3 Chinese medicine ointment
Chinese medicine clear paste powder 20g
Glyceryl monostearate 100g
Paraffin 100g
White vaseline 50g
Liquid paraffin 55g
Propylene glycol 50g
Sorbester p17 6g
Ethylparaben 1.2g
Purified water adds to 1000ml
Preparation technology: get paraffin, glyceryl monostearate, white vaseline, liquid paraffin, propylene glycol, sorbester p17 and ethylparaben heat fused keep 80 ℃ in water-bath, slowly add the water of 80 ℃ under stirring, the limit edged is stirred to condensation, i.e. ointment base.Get Chinese medicine clear paste powder and be dissolved in appropriate purified water, join in substrate, finally add water to full dose, obtain.
The preparation of embodiment 4 Chinese medicine suppository
Chinese medicine clear paste powder 20g
Semi-synthetic fatty glyceride 350g
Tween 80 1.5g
Preparation technology: get semi-synthetic fatty glyceride and put in vessel, heating in water bath melts, and treats that temperature is down to 50 ℃ of left and right, add Tween 80, stir, add Chinese medicine clear paste powder, stir, rear injection scribbles the bolt mould of lubricant to slightly overflowing die orifice for degree, cooling, prunes after solidifying and overflows part, the demoulding, quality inspection, packing, obtain.
The preparation of the blank ointment of comparative example
Glyceryl monostearate 100g
Paraffin 100g
White vaseline 50g
Liquid paraffin 55g
Propylene glycol 50g
Sorbester p17 6g
Ethylparaben 1.2g
Purified water adds to 1000ml
Preparation technology: get paraffin, glyceryl monostearate, white vaseline, liquid paraffin, propylene glycol, sorbester p17 and ethylparaben heat fused keep 80 ℃ in water-bath, slowly add the purified water of 80 ℃ under stirring, the limit edged is stirred to condensation, i.e. blank ointment.
The impact of embodiment 5 Chinese medicine ointment on rat Oleum Tiglii hemorrhoid model
Modeling method: Oleum Tiglii is a kind of proinflammatory agent commonly used, 1 part of distilled water, 4 parts of pyridines, 5 parts of ether and 10 part of 15% Oleum Tiglii diethyl ether solution preparation for Oleum Tiglii mixed liquor commonly used.Be stained with Oleum Tiglii with the 10mg cotton balls, the cotton balls after soaking is put into to the rat anal, stop and take out afterwards in 15 seconds.
36 SD rats (200 gram left and right) are divided into three groups at random by body weight: model control group (the blank ointment of administration), Ma Yinglong group (administration MAYINGLONG MUSK HEMORRHOID UNGUENTUM), test group (Chinese medicine ointment of administration embodiment 3 preparations), 12 every group.Rat is carried a few days ago drop rectum with drug, and every day, each once, was stained with medicine with the 10mg cotton balls sooner or later, and cotton balls is filled in to internal rectum, during next administration, should first check whether internal rectum has cotton balls (should take out if any cotton balls).Last administration should be after modeling 2 hours.Last administration is after 5 hours, every blue normal saline solution (2ml/kg) of rat intravenous injection 1% she Wen, sacrificed by exsanguination animal after 40 minutes, cut-off intestinal and anus surrounding tissue, the rear use acetone normal saline 7:3 solution soaking of weighing 48 hours, centrifugal 10 minutes of 3000rpm, get supernatant and survey absorbance in 590nm, as estimating the vascular permeability index, the results are shown in Table 1.
Result of the test by table 1 can find out, Chinese medicine ointment of the present invention can well reduce the rectum vein permeability of Oleum Tiglii hemorrhoid model mice, with Ma Yinglong group there was no significant difference.
The comparison of each treatment group of table 1 and model control group absorbance
| Group | The rat number of elements | Absorbance |
| Model control group | 12 | 0.150±0.041 |
| The Ma Yinglong group | 12 | ?0.107±0.046 ★ |
| Test group | 12 | ?0.113±0.030 ★ |
★compare P<0.05 with matched group;
★ ★compare P<0.01 with matched group.
The impact of embodiment 6 Chinese medicine ointment on mice dimethylbenzene inflammatory model
36 KM mices, male and female half and half, body weight 25-30 gram is divided into three groups at random by body weight: model control group (the blank ointment of administration), Ma Yinglong group (administration MAYINGLONG MUSK HEMORRHOID UNGUENTUM), test group (Chinese medicine ointment of administration embodiment 3 preparations), 12 every group.Get dimethylbenzene 20 μ l, be applied to mouse right ear.Get after 30min and respectively be subject to reagent evenly to be applied to respectively mouse right ear, put to death after administration 3h.Along the auricle baseline, place cuts two ears, with the 8mm card punch, at the same position of left and right ear, lays auricle, weighs, and the ear method of double differences=auris dextra sheet weight-left auricle weight, the results are shown in Table 2.
Result of the test by table 2 can find out, Chinese medicine ointment of the present invention has obvious antiinflammatory action, and the antiinflammatory curative effect is better than the Ma Yinglong treatment group.
Each treatment group of table 2 and the model control group ear method of double differences are relatively
| Group | The rat number of elements | The ear method of double differences (mg) |
| Model control group | 12 | 7.17±2.47 |
| The Ma Yinglong group | 12 | 4.97±2.61 ★ |
| Test group | 12 | 3.08±1.83 ★★● |
★compare P<0.05 with matched group;
★ ★compare P<0.01 with matched group;
●organize P<0.05 with Ma Yinglong;
● ●compare P<0.01 with the Ma Yinglong group.
The impact of embodiment 7 Chinese medicine ointment on pain model in mice
36 of KM mices, male and female half and half, body weight 25-30 gram is divided into three groups at random by body weight: model control group (the blank ointment of administration), Ma Yinglong group (administration MAYINGLONG MUSK HEMORRHOID UNGUENTUM), test group (Chinese medicine ointment of administration embodiment 3 preparations), 12 every group.The mice anum administration, be stained with medicine with the 10mg cotton balls, and cotton balls is filled in to internal rectum, once a day, continuous three days, after last administration 30 minutes, apart from anus 3.5cm place rectal wall, injects 5% formalin 0.2ml.Record writhing number of times in mice 20 minutes.Concrete outcome is in Table 3.
Result of the test by table 2 can find out, Chinese medicine ointment of the present invention has fairly obvious analgesic effect, with Ma Yinglong group there was no significant difference.
Each treatment group of table 3 and model control group writhing number of times are relatively
| Group | The rat number of elements | The writhing number of times |
| Model control group | 12 | 48.3±11.7 |
| The Ma Yinglong group | 12 | ? 36.7±12.6 ★ |
| Test group | 12 | ? 33.0±15.1 ★ |
★compare P<0.05 with matched group;
★ ★compare P<0.01 with matched group.
Claims (7)
1. an external preparation for the treatment of hemorrhoid, comprise active component and pharmaceutically acceptable adjuvant, it is characterized in that described active component is prepared from through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion: Radix Sanguisorbae 8-13 part, Flos Lonicerae 8-13 part, Radix Stemonae 8-13 part, Rhizoma Chuanxiong 10-18 part, Flos Sophorae 10-18 part, Herba Agrimoniae 10-18 part, Herba portulacae 10-18 part, Fructus Arctii 25-35 part, Cortex Dictamni 25-35 part.
2. treat according to claim 1 the external preparation of hemorrhoid, it is characterized in that described active component is prepared from through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion: 10 parts of Radix Sanguisorbaes, 10 parts of Flos Loniceraes, 10 parts of the Radixs Stemonae, 14 parts of Rhizoma Chuanxiongs, 14 parts, Flos Sophorae, 14 parts of Herba Agrimoniaes, 14 parts of Herba portulacaes, 30 parts of Fructus Arctiis, 30 parts of Cortex Dictamni.
3. according to the external preparation of the described treatment hemorrhoid of claim 1 or 2, it is characterized in that: described external preparation is gel, ointment, suppository or ointment.
4. treat according to claim 3 the external preparation of hemorrhoid, it is characterized in that: when described external preparation is gel, described pharmaceutically acceptable adjuvant is selected from the two or more of carbomer, propylene glycol, glycerol, triethanolamine and cellulose derivative.
5. treat according to claim 3 the external preparation of hemorrhoid, it is characterized in that: when described external preparation is ointment, described pharmaceutically acceptable adjuvant is selected from two or more in glyceryl monostearate, glycerol, propylene glycol, stearic acid, white vaseline, triethanolamine, sodium lauryl sulphate and ethyl hydroxybenzoate.
6. treat according to claim 3 the external preparation of hemorrhoid, it is characterized in that: when described external preparation is suppository, described pharmaceutically acceptable adjuvant is selected from two or more in semi-synthetic fatty glyceride, glycerol, gelatin and Polyethylene Glycol.
7. treat according to claim 3 the external preparation of hemorrhoid, it is characterized in that: when described external preparation is ointment, described pharmaceutically acceptable adjuvant is selected from two or more in glyceryl monostearate, paraffin, white vaseline, liquid paraffin, propylene glycol, P-hydroxybenzoic acid second and sorbester p17.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169456A (en) * | 2015-08-25 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Medical biological hydrogel functional dressing for hemorrhoid and preparation method thereof |
| CN105943655A (en) * | 2016-05-04 | 2016-09-21 | 昆明理工大学 | Compound ointment for treating hemorrhoids and preparation method of compound ointment |
| CN106266301A (en) * | 2015-06-04 | 2017-01-04 | 刘飞德 | A kind of Chinese medicine composition treating inflammatory external hemorrhoid and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000175A (en) * | 2010-11-17 | 2011-04-06 | 黄文珍 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
| CN102772598A (en) * | 2012-08-20 | 2012-11-14 | 解连新 | Traditional Chinese medicine for treating bacillary dysentery |
-
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- 2013-09-10 CN CN201310407920.0A patent/CN103432497B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000175A (en) * | 2010-11-17 | 2011-04-06 | 黄文珍 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
| CN102772598A (en) * | 2012-08-20 | 2012-11-14 | 解连新 | Traditional Chinese medicine for treating bacillary dysentery |
Non-Patent Citations (1)
| Title |
|---|
| 赵国鸣等: "肛肠安胶囊治疗痔疮188例疗效观察", 《云南中医中药杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266301A (en) * | 2015-06-04 | 2017-01-04 | 刘飞德 | A kind of Chinese medicine composition treating inflammatory external hemorrhoid and preparation method thereof |
| CN105169456A (en) * | 2015-08-25 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Medical biological hydrogel functional dressing for hemorrhoid and preparation method thereof |
| CN105943655A (en) * | 2016-05-04 | 2016-09-21 | 昆明理工大学 | Compound ointment for treating hemorrhoids and preparation method of compound ointment |
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