CN106511864A - Traditional Chinese medicine composition and preparation method and applications thereof in treatment of cervical carcinoma - Google Patents
Traditional Chinese medicine composition and preparation method and applications thereof in treatment of cervical carcinoma Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition and a preparation method and applications thereof in treatment of cervical carcinoma. The traditional Chinese medicine composition comprises the following raw materials: radix angelicae sinensis, rhizoma ligustici chuanxiong, poria, cortex cinnamomi, radix rehmanniae preparata, radix codonopsis, radix glycyrrhizae, radix paeoniae alba, rhizoma atractylodis macrocephalae, radix astragali seu hedysari, pulp of cornus, rhizoma dioscoreae, fructus schisandrae chinensis, fructus alpiniae oxyphyllae, fructus jujubae, radix salviae miltiorrhizae, radix adenophorae, hippocampus, fructus lycii, radix polygalae, gecko, radix ginseng, tortoise plastron, sesamum indicum and herba epimedii. The traditional Chinese medicine composition can inhibit or kill carcinoma cells, soften and reduce tumor, and eliminate carcinoma lesions, the organism immunity of patients with cervical carcinoma can be enhanced, the bearing capability of the patients can be increased, and the treatment possibility can be increased; the radix angelicae sinensis, radix rehmanniae preparata, radix codonopsis, radix glycyrrhizae and the like chosen in the formula of the medicine composition have the efficacies of replenishing blood and benefitting qi, and the dual depletion of qi and blood of patients can be obviously improved; the ingredients in the medicine can be absorbed by 100% due to micromolecules changed from macromolecules through solid-state fermentation, the efficacies can be enhanced, and the taste of the traditional Chinese medicine can be improved due to the addition of honey.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, and in particular to a kind of Chinese medicine composition and preparation method thereof and treatment cervix uteri
The application of cancer.
Background technology
Cervical cancer is one of female tumor common in the world, not only accounts for first place in tumors of female reproductive organ, and
It is most common tumor in the various malignant tumor of women, drastically influence the health of women.
At present, conventional Therapeutic Method has operative treatment, radiotherapy, chemotherapy etc..It is big when being made a definite diagnosis due to cervical cancer
Part in, late period is generally required and is treated using integrated approach.Although radiotherapy, chemotherapy have certain effect,
But its toxic and side effects is big, while cancerous cell is killed, many normal cells of human body is also killed, causes the normal organ of patient
And digestive system is damaged by different degrees of, patient's body's immunity is caused to decline, the normal hypofunction of body.And in
Medicine is received more and more attention as which has the advantages such as anticancer suppression is swollen, toxic and side effects are little, but existing on market is directed to
The Chinese medicine of cervical cancer is but more rare.
The content of the invention
It is an object of the invention to provide the application of a kind of Chinese medicine composition and preparation method thereof and treatment cervical cancer, Chinese medicine
Compositionss all select natural Chinese medicinal herb, can effectively treatment cervical cancer and be effectively improved patients blood two lose symptom.
The technical scheme is that：A kind of Chinese medicine composition, including the raw material of following weight portion：4～36 parts of Radix Angelicae Sinensis, river
3～25 parts of rhizome of chuanxiong, 4～30 parts of Poria, 3～25 parts of Cortex Cinnamomi, 8～28 parts of Radix Rehmanniae Preparata, 6～32 parts of Radix Codonopsis, 5～25 parts of Radix Glycyrrhizae, the Radix Paeoniae Alba 3
～25 parts, 8～28 parts of the Rhizoma Atractylodis Macrocephalae, 4～30 parts of the Radix Astragali, 5～25 parts of Fructus Corni, 4～36 parts of Rhizoma Dioscoreae, 4～30 parts of Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae
3～25 parts, 6～32 parts of Fructus Jujubae, 3～25 parts of Radix Salviae Miltiorrhizae, 3～25 parts of Radix Adenophorae (Radix Glehniae), 8～28 parts of Hippocampus, 4～36 parts of Fructus Lycii, Radix Polygalae 4～32
Part, 6～32 parts of Gecko, 3～25 parts of Radix Ginseng, 5～25 parts of Rhizoma Polygonati, 3～25 parts of Carapax et Plastrum Testudiniss, 3～25 parts of Semen sesami Niger, Herba Epimedii 6～32
Part.
Preferably, Chinese medicine composition of the present invention, including the raw material of following weight portion：12～28 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiong 12
～16 parts, 15～20 parts of Poria, 12～16 parts of Cortex Cinnamomi, 14～22 parts of Radix Rehmanniae Preparata, 14～24 parts of Radix Codonopsis, 12～18 parts of Radix Glycyrrhizae, in vain
12～16 parts of Chinese herbaceous peony, 14～22 parts of the Rhizoma Atractylodis Macrocephalae, 15～20 parts of the Radix Astragali, 12～18 parts of Fructus Corni, 12～28 parts of Rhizoma Dioscoreae, Fructus Schisandrae Chinensis 15～20
Part, 12～16 parts of Fructus Alpiniae Oxyphyllae, 14～24 parts of Fructus Jujubae, 12～16 parts of Radix Salviae Miltiorrhizae, 12～16 parts of Radix Adenophorae (Radix Glehniae), 14～22 parts of Hippocampus, Fructus Lycii 12
～28 parts, 12～24 parts of Radix Polygalae, 14～24 parts of Gecko, 12～16 parts of Radix Ginseng, 12～18 parts of Rhizoma Polygonati, 12～16 parts of Carapax et Plastrum Testudiniss, huge victory
12～16 parts of son, 14～24 parts of Herba Epimedii.
Preferably, Chinese medicine composition of the present invention, including the raw material of following weight portion：28 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiong, Fu
18 parts of Siberian cocklebur, 15 parts of Cortex Cinnamomi, 20 parts of Radix Rehmanniae Preparata, 22 parts of Radix Codonopsis, 13 parts of Radix Glycyrrhizae, 13 parts of the Radix Paeoniae Alba, 20 parts of the Rhizoma Atractylodis Macrocephalae, 16 parts of the Radix Astragali, mountain cornel
14 parts of meat, 15 parts of Rhizoma Dioscoreae, 16 parts of Fructus Schisandrae Chinensis, 13 parts of Fructus Alpiniae Oxyphyllae, 16 parts of Fructus Jujubae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Adenophorae (Radix Glehniae), 16 parts of Hippocampus, Chinese holly
18 parts of Qi, 16 parts of Radix Polygalae, 24 parts of Gecko, 13 parts of Radix Ginseng, 16 parts of Rhizoma Polygonati, 15 parts of Carapax et Plastrum Testudiniss, 15 parts of Semen sesami Niger, 20 parts of Herba Epimedii.
Optimal, Chinese medicine composition of the present invention, including the raw material of following weight portion：20 parts of Radix Angelicae Sinensis, 14 parts of Rhizoma Chuanxiong, Fu
17 parts of Siberian cocklebur, 14 parts of Cortex Cinnamomi, 18 parts of Radix Rehmanniae Preparata, 19 parts of Radix Codonopsis, 15 parts of Radix Glycyrrhizae, 14 parts of the Radix Paeoniae Alba, 18 parts of the Rhizoma Atractylodis Macrocephalae, 17 parts of the Radix Astragali, mountain cornel
15 parts of meat, 20 parts of Rhizoma Dioscoreae, 17 parts of Fructus Schisandrae Chinensis, 14 parts of Fructus Alpiniae Oxyphyllae, 19 parts of Fructus Jujubae, 14 parts of Radix Salviae Miltiorrhizae, 14 parts of Radix Adenophorae (Radix Glehniae), 18 parts of Hippocampus, Chinese holly
20 parts of Qi, 18 parts of Radix Polygalae, 19 parts of Gecko, 14 parts of Radix Ginseng, 15 parts of Rhizoma Polygonati, 14 parts of Carapax et Plastrum Testudiniss, 14 parts of Semen sesami Niger, 19 parts of Herba Epimedii.
The Chinese medicine composition makes pharmaceutically acceptable preparation.
Further, the preparation is any one in tablet, capsule, pill, granule or powder.
The preparation method of the Chinese medicine composition, comprises the following steps：The first step, weighs Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fu by weight
Siberian cocklebur, Cortex Cinnamomi, Radix Rehmanniae Preparata, Radix Codonopsis, Radix Glycyrrhizae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Corni, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae, Fructus Jujubae, Radix Salviae Miltiorrhizae,
Radix Adenophorae (Radix Glehniae), Hippocampus, Fructus Lycii, Radix Polygalae, Gecko, Radix Ginseng, Rhizoma Polygonati, Carapax et Plastrum Testudiniss, Semen sesami Niger, Herba Epimedii, crush, sieve, and mix homogeneously is obtained
Fermentation raw material；Second step, Mel is added in fermentation raw material, loads fermentation tank and fermented after stirring；3rd step,
At 33～40 DEG C, ferment 8～12 days, extract at low temperature at 20～60 DEG C obtains moist powder；4th step, adds adjuvant, be dried,
Make pharmaceutically acceptable preparation.
In second step, the strain is Mel or probiotic bacteria.
Further, the Mel is 1～2 with the part by weight of fermentation raw material:1, the probiotic bacteria and fermentation raw material
Part by weight is 0.05～0.1:1.
Further, the probiotic bacteria be lactic acid bacteria, bacillus bifiduss, one or two in yeast.
In 3rd step, at 37 DEG C, ferment 10 days, the extract at low temperature at 45 DEG C obtains moist powder.
The invention further relates to application of the Chinese medicine composition in treatment cervix uteri cancer drug is prepared.
, wherein it is desired to explanation, for the purpose of the present invention is realized, the Chinese medicine composition of the present invention is not limited to
Above-mentioned preparation method, present invention only provides a kind of specific preparation method.
In Chinese medicine composition of the present invention, the selected herbal pharmacology property of medicine is described below：
Radix Angelicae Sinensis, sweet in the mouth, pungent, warm in nature, Return liver, the heart, spleen channel have functions that to enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation,
Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, poly- lump in the abdomen knot, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine just
Weight, ulcer sores, injury from falling down after difficult, bloody dysentery.
Rhizoma Chuanxiong, acrid in the mouth are warm in nature, Return liver, gallbladder meridian, have functions that activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain, cure mainly wind
Cold head pain revolves dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.
Poria, sweet in the mouth, light, mild-natured, GUIXIN, lung, spleen, kidney channel, has functions that promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming, cures mainly water
Swollen oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool are had loose bowels, irritability, insomnia of palpitating with fear.
Cortex Cinnamomi, acrid in the mouth, sweet, property heat, returns kidney, spleen, the heart, Liver Channel, with mends fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation
The effect stimulated the menstrual flow, cure mainly cold weak pulse of limb, YANG-depletion collapse, stomachache have loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, stream
Note, and empty sun is floating more, heat in the upper and cold in the lower.
Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature return liver and kidney channel, have functions that enrich blood moist, beneficial essence fill out marrow, cure mainly and wither in blood deficiency
Huang, dizziness palpitaition, menoxenia, collapse more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, menoxenia, metrorrhagia
Hematochezia, soreness of the waist and knees, Hiccough and deaf, head is dim-sighted, early whitening of beard and hair, quench one's thirst, constipation, syndrome characterized by dyspnea.
Radix Codonopsis, mild-natured, sweet in the mouth, micro- acid, returns spleen, lung meridian have functions that invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung, cure mainly insufficiency of the spleen food
Few loose stool, myasthenia of limbs, cardiopalmus, shortness of breath, xerostomia, spontaneous perspiration, proctoptosis.
Radix Glycyrrhizae, sweet in the mouth are mild-natured, returns spleen, stomach, lung meridian, with invigorating middle warmer and replenishing QI, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication,
Effect of coordinating the actions of various ingredients in a prescription, cures mainly weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion, controls throat
Swell and ache, peptic ulcer, ulcer sores, solution poison of drug and alimentary toxicosis.
The Radix Paeoniae Alba, bitter in the mouth, acid, cold nature, Return liver, spleen channel, with enriching blood, yin fluid astringing easing the affected liver, effect of relieving spasm to stop pain cures mainly head
Pain dizziness, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
The Rhizoma Atractylodis Macrocephalae, bitter in the mouth are warm in nature, returns spleen, stomach, with invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of.Cure mainly spleen
Empty lack of appetite, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, edema, spontaneous perspiration, frequent fetal movement.
The Radix Astragali, sweet in the mouth, slightly warm in nature, return lung, spleen, liver and kidney channel, with invigorating QI to consolidate the body surface resistance, diuretic and maintain drug, evacuation of pus, expelling pus and promoting granulation
Effect, cure mainly treatment deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle
Cellulitis difficult routed, bursts for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes.
Fructus Corni, sour in the mouth, puckery, slightly warm in nature, have functions that invigorating the liver and kidney, beneficial vital essence, it is solid collapse, cure mainly soreness of waist and knee joint, dizzy
Dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shake scattered pulse.
Rhizoma Dioscoreae, sweet in the mouth are mild-natured, returns spleen, lung, kidney channel, have functions that invigorating spleen and reinforcing stomach, kidney nourishing and replenishing vital essence, benefit lung and restrain cough.
Fructus Schisandrae Chinensis, sour in the mouth are warm in nature, return lung, kidney channel, have functions that to restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, mind tranquilizing and the heart calming, cure mainly
Chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, injury thirst, deficient pulse of losing heart, Heat Diabetes, cardiopalmus
Insomnia.
Fructus Alpiniae Oxyphyllae, acrid in the mouth are warm in nature, returns spleen, kidney channel, have functions that warming the spleen, antidiarrheal, take the photograph saliva, warming the kidney, reducing urination, controlling nocturnal emission with astringent drugs, main
Control Deficiency and coldness of spleen and stomach, vomit, have loose bowels, cold type of pain, many salivas of mouth, enuresis due to deficiency of the kidney, frequent micturition, seminal emission, nebulousurine in abdomen.
Fructus Jujubae, acrid in the mouth, sweet, warm in nature, GUIXIN, liver, spleen channel, has functions that replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation,
Cure mainly blood deficiency, menoxenia, traumatic injury, rheumatic arthralgia.
Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature, GUIXIN, Liver Channel, with blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle
Effect, cures mainly obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass accumulation, hot numbness pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection
Swell and ache.
Radix Adenophorae (Radix Glehniae), sweet in the mouth, slight bitter, cold nature attach to the lung and stomach meridians, and have functions that replenishing YIN and removing heat, moistening the lung and resolving phlegm, reinforcing stomach reg fluid,
Cure mainly main yin chronic cough, consumptive disease to cough few expectorant blood, cough caused by dryness expectorant, deficiency-heat sore throat, injury thirst.
Hippocampus, the effects such as with building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma.
Fructus Lycii, sweet in the mouth are mild-natured, have functions that nourishing the liver, nourishing kidney, lung moistening.
Radix Polygalae, bitter in the mouth, pungent, warm in nature, GUIXIN, kidney, lung meridian, has functions that tranquilize the mind and promote the intelligence, resolving depression, controls palpitation with fear, forgetful, dream
Something lost, insomnia, cough ant phlegm, carbuncle sore swells.
Gecko, salty in the mouth are mild-natured, return lung, kidney channel, have functions that kidney tonifying tonifying the lung, Dingchuan, antitussive, cure mainly palpitation with fear, it is forgetful,
Nocturnal emission, insomnia, cough ant phlegm, carbuncle sore swells.
Radix Ginseng, sweet in the mouth, slight bitter are warm in nature, flat, returns spleen, lung, heart channel, with QI invigorating, take off admittedly, promote the production of body fluid, calming the nerves, the work(of Fructus Alpiniae Oxyphyllae
Effect, cure mainly weak body and prostration, cold weak pulse of limb, spleen eating less, the deficiency of the lung breath with cough, injury thirst, Heat Diabetes, prolonged illness weakness with emaciation, palpitation with fear lose
Dormancy, sexual impotence cold womb, heart failure, cardiogenic shock.
Rhizoma Polygonati, sweet in the mouth are mild-natured, returns spleen, lung, kidney channel, have functions that boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying, cure mainly spleen
Insufficiency of stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, beard and hair morning
In vain, Heat Diabetes.
Carapax et Plastrum Testudiniss, salty in the mouth are sweet, mild-natured, GUIXIN, spleen, lung meridian, have functions that YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone, cure mainly kidney yin
Deficiency, hectic fever due to YIN-deficiency consumptive fever, haematemesis, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid
Skin ulcer.
Semen sesami Niger, bitter in the mouth, pungent, slightly warm in nature, returns liver and kidney channel, has functions that liver and kidney tonifying, promoting blood circulation, black beard and hair, cures mainly waist
Bitterly, bleeding not during menses, seminal emission, bones and tendons injury pain.
Herba Epimedii, acrid in the mouth are warm in nature, have functions that kidney invigorating and YANG supporting, remove rheumatism, cure mainly impotence due to deficiency of the kidney, premature ejaculation of passing out semen, waist
Knees soreness, cold extremities with aversion to cold, arthralgia due to cold-dampnes, spasm of the limbs numbness etc..
Raw material selected by Chinese medicine composition of the present invention can synergism, suppress or kill cancerous cell, soften reduce tumor, disappear
Except cancer is made, while the immunity of organisms of cervical cancer patient can be effectively improved, increase the ability to bear of patient, can prevent recurrence and
Transfer, increases the chance for the treatment of；Selected Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Codonopsis, Radix Glycyrrhizae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng in drug regimen composition formula
Deng having functions that to enrich blood, QI invigorating, can obviously improve the symptom that patients blood two loses；Chinese medicine composition of the present invention is through solid-state
Fermentation, becomes small molecule by macromole, can be absorbed by the body with 100%, improves curative effect.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with specific embodiment pair
The present invention is further described.It should be appreciated that specific embodiment described herein is only to explain the present invention, but and
It is not used in the restriction present invention.
Embodiment 1
The first step, weighs Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 3g, Poria 4g, Cortex Cinnamomi 3g, Radix Rehmanniae Preparata 8g, Radix Codonopsis 6g, Radix Glycyrrhizae 5g, Radix Paeoniae Alba 3g,
Rhizoma Atractylodis Macrocephalae 8g, Radix Astragali 4g, Fructus Corni 5g, Rhizoma Dioscoreae 4g, Fructus Schisandrae Chinensis 4g, Fructus Alpiniae Oxyphyllae 3g, Fructus Jujubae 6g, Radix Salviae Miltiorrhizae 3g, Radix Adenophorae (Radix Glehniae) 3g, Hippocampus 8g,
Fructus Lycii 4g, Radix Polygalae 4g, Gecko 6g, Radix Ginseng 3g, Rhizoma Polygonati 5g, Carapax et Plastrum Testudiniss 3g, Semen sesami Niger 3g, Herba Epimedii 6g are crushed, are sieved, and mixing is equal
It is even to obtain fermentation raw material；Second step, Mel 118g is added in fermentation raw material, and loading fermentation tank after stirring carries out sending out
Ferment；3rd step, at 33 DEG C, ferments 12 days, and extract at low temperature at 20 DEG C obtains moist powder；4th step, adds in moist powder
Enter dextrin, tabletting is dried, makes tablet.
Embodiment 2
The first step, weighs Radix Angelicae Sinensis 36g, Rhizoma Chuanxiong 25g, Poria 30g, Cortex Cinnamomi 25g, Radix Rehmanniae Preparata 28g, Radix Codonopsis 32g, Radix Glycyrrhizae 25g,
Radix Paeoniae Alba 25g, Rhizoma Atractylodis Macrocephalae 28g, Radix Astragali 30g, Fructus Corni 25g, Rhizoma Dioscoreae 36g, Fructus Schisandrae Chinensis 30g, Fructus Alpiniae Oxyphyllae 25g, Fructus Jujubae 32g, Radix Salviae Miltiorrhizae
25g, Radix Adenophorae (Radix Glehniae) 25g, Hippocampus 28g, Fructus Lycii 36g, Radix Polygalae 32g, Gecko 32g, Radix Ginseng 25g, Rhizoma Polygonati 25g, Carapax et Plastrum Testudiniss 25g, Semen sesami Niger
25g, Herba Epimedii 32g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 890g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 35 DEG C, ferments 11 days, and extract at low temperature at 25 DEG C is obtained
Moist powder；4th step, adds starch in moist powder, is dried, makes pill.
Embodiment 3
The first step, weighs Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 14g, Poria 17g, Cortex Cinnamomi 14g, Radix Rehmanniae Preparata 18g, Radix Codonopsis 19g, Radix Glycyrrhizae 15g,
Radix Paeoniae Alba 14g, Rhizoma Atractylodis Macrocephalae 18g, Radix Astragali 17g, Fructus Corni 15g, Rhizoma Dioscoreae 20g, Fructus Schisandrae Chinensis 17g, Fructus Alpiniae Oxyphyllae 14g, Fructus Jujubae 19g, Radix Salviae Miltiorrhizae
14g, Radix Adenophorae (Radix Glehniae) 14g, Hippocampus 18g, Fructus Lycii 20g, Radix Polygalae 18g, Gecko 19g, Radix Ginseng 14g, Rhizoma Polygonati 15g, Carapax et Plastrum Testudiniss 14g, Semen sesami Niger
14g, Herba Epimedii 19g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 680g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 37 DEG C, ferments 10 days, and extract at low temperature at 45 DEG C is obtained
Moist powder；4th step, adds dextrin in moist powder, drying of pelletizing, and makes granule.
Embodiment 4
The first step, weighs Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Poria 15g, Cortex Cinnamomi 12g, Radix Rehmanniae Preparata 14g, Radix Codonopsis 14g, Radix Glycyrrhizae 12g,
Radix Paeoniae Alba 12g, the Rhizoma Atractylodis Macrocephalae 14, Radix Astragali 15g, Fructus Corni 12g, Rhizoma Dioscoreae 12g, Fructus Schisandrae Chinensis 15g, Fructus Alpiniae Oxyphyllae 12g, Fructus Jujubae 14g, Radix Salviae Miltiorrhizae 12g,
Radix Adenophorae (Radix Glehniae) 12g, Hippocampus 14g, Fructus Lycii 12g, Radix Polygalae 12g, Gecko 14g, Radix Ginseng 12g, Rhizoma Polygonati 12g, Carapax et Plastrum Testudiniss 12g, Semen sesami Niger 12g are excessive
Sheep leaves of pulse plants 14g, crushes, sieves, and mix homogeneously obtains fermentation raw material；Second step, Mel 670g is added in fermentation raw material, stirring
Load fermentation tank to be fermented after uniform；3rd step, at 38 DEG C, ferments 9 days, and extract at low temperature at 30 DEG C obtains moist powder；
4th step, adds starch in moist powder, is dried, makes powder.
Embodiment 5
The first step, weighs Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 16g, Poria 20g, Cortex Cinnamomi 16g, Radix Rehmanniae Preparata 22g, Radix Codonopsis 24g, Radix Glycyrrhizae 18g,
Radix Paeoniae Alba 16g, Rhizoma Atractylodis Macrocephalae 22g, Radix Astragali 20g, Fructus Corni 18g, Rhizoma Dioscoreae 28g, Fructus Schisandrae Chinensis 20g, Fructus Alpiniae Oxyphyllae 16g, Fructus Jujubae 24g, Radix Salviae Miltiorrhizae
16g, Radix Adenophorae (Radix Glehniae) 16g, Hippocampus 22g, Fructus Lycii 28g, Radix Polygalae 24g, Gecko 24g, Radix Ginseng 16g, Rhizoma Polygonati 18g, Carapax et Plastrum Testudiniss 16g, Semen sesami Niger
16g, Herba Epimedii 24g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 633g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 45 DEG C obtains tide
Wet powder；4th step, adds starch in moist powder, is dried, makes powder.
Embodiment 6
The first step, weighs Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 15g, Poria 18g, Cortex Cinnamomi 15g, Radix Rehmanniae Preparata 20g, Radix Codonopsis 22g, Radix Glycyrrhizae 13g,
Radix Paeoniae Alba 13g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 16g, Fructus Corni 14g, Rhizoma Dioscoreae 15g, Fructus Schisandrae Chinensis 16g, Fructus Alpiniae Oxyphyllae 13g, Fructus Jujubae 16g, Radix Salviae Miltiorrhizae
15g, Radix Adenophorae (Radix Glehniae) 15g, Hippocampus 16g, Fructus Lycii 18g, Radix Polygalae 16g, Gecko 24g, Radix Ginseng 13g, Rhizoma Polygonati 16g, Carapax et Plastrum Testudiniss 15g, Semen sesami Niger
15g, Herba Epimedii 20g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 611g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 60 DEG C obtains tide
Wet powder；4th step, adds starch in moist powder, is dried, makes powder.
Embodiment 7
The first step, weighs Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, Poria 16g, Cortex Cinnamomi 13g, Radix Rehmanniae Preparata 16g, Radix Codonopsis 18g, Radix Glycyrrhizae 14g,
Radix Paeoniae Alba 15g, Rhizoma Atractylodis Macrocephalae 16g, Radix Astragali 19g, Fructus Corni 16g, Rhizoma Dioscoreae 22g, Fructus Schisandrae Chinensis 18g, Fructus Alpiniae Oxyphyllae 15g, Fructus Jujubae 21g, Radix Salviae Miltiorrhizae
13g, Radix Adenophorae (Radix Glehniae) 13g, Hippocampus 20g, Fructus Lycii 22g, Radix Polygalae 22g, Gecko 17g, Radix Ginseng 15g, Rhizoma Polygonati 13g, Carapax et Plastrum Testudiniss 13g, Semen sesami Niger
12g, Herba Epimedii 17g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 550g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 60 DEG C obtains tide
Wet powder；4th step, adds dextrin in moist powder, is dried, filling dress capsule, makes capsule.
Embodiment 8
The first step, weighs Radix Angelicae Sinensis 21g, Rhizoma Chuanxiong 12g, Poria 19g, Cortex Cinnamomi 13g, Radix Rehmanniae Preparata 17g, Radix Codonopsis 21g, Radix Glycyrrhizae 17g,
Radix Paeoniae Alba 13g, Rhizoma Atractylodis Macrocephalae 21g, Radix Astragali 18g, Fructus Corni 14g, Rhizoma Dioscoreae 25g, Fructus Schisandrae Chinensis 16g, Fructus Alpiniae Oxyphyllae 13g, Fructus Jujubae 16g, Radix Salviae Miltiorrhizae
15g, Radix Adenophorae (Radix Glehniae) 15g, Hippocampus 16g, Fructus Lycii 19g, Radix Polygalae 16g, Gecko 23g, Radix Ginseng 13g, Rhizoma Polygonati 14g, Carapax et Plastrum Testudiniss 15g, Semen sesami Niger
12g, Herba Epimedii 21g, crush, sieve, and mix homogeneously obtains fermentation raw material；Mel 780g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 38 DEG C, ferments 9 days, and extract at low temperature at 55 DEG C obtains tide
Wet powder；4th step, adds starch in moist powder, is dried, makes pill.
In embodiment 1-8, using Mel as strain raw material, the addition of Mel can improve Chinese medicine taste.
Embodiment 9
The first step, weighs Radix Angelicae Sinensis 21g, Rhizoma Chuanxiong 12g, Poria 19g, Cortex Cinnamomi 13g, Radix Rehmanniae Preparata 17g, Radix Codonopsis 21g, Radix Glycyrrhizae 17g,
Radix Paeoniae Alba 13g, Rhizoma Atractylodis Macrocephalae 21g, Radix Astragali 18g, Fructus Corni 14g, Rhizoma Dioscoreae 25g, Fructus Schisandrae Chinensis 16g, Fructus Alpiniae Oxyphyllae 13g, Fructus Jujubae 16g, Radix Salviae Miltiorrhizae
15g, Radix Adenophorae (Radix Glehniae) 15g, Hippocampus 16g, Fructus Lycii 19g, Radix Polygalae 16g, Gecko 23g, Radix Ginseng 13g, Rhizoma Polygonati 14g, Carapax et Plastrum Testudiniss 15g, Semen sesami Niger
12g, Herba Epimedii 21g, crush, sieve, and mix homogeneously obtains fermentation raw material；21.6g lactic acid bacterias are added to proferment by second step
In material, load fermentation tank after stirring and fermented；3rd step, at 38 DEG C, ferments 9 days, and extract at low temperature at 55 DEG C is obtained
Moist powder；4th step, adds starch in moist powder, is dried, makes pill.
Embodiment 10
The first step, weighs Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 15g, Poria 16g, Cortex Cinnamomi 13g, Radix Rehmanniae Preparata 16g, Radix Codonopsis 18g, Radix Glycyrrhizae 14g,
Radix Paeoniae Alba 15g, Rhizoma Atractylodis Macrocephalae 16g, Radix Astragali 19g, Fructus Corni 16g, Rhizoma Dioscoreae 22g, Fructus Schisandrae Chinensis 18g, Fructus Alpiniae Oxyphyllae 15g, Fructus Jujubae 21g, Radix Salviae Miltiorrhizae
13g, Radix Adenophorae (Radix Glehniae) 13g, Hippocampus 20g, Fructus Lycii 22g, Radix Polygalae 22g, Gecko 17g, Radix Ginseng 15g, Rhizoma Polygonati 13g, Carapax et Plastrum Testudiniss 13g, Semen sesami Niger
12g, Herba Epimedii 17g, crush, sieve, and mix homogeneously obtains fermentation raw material；42.3g yeast is added to proferment by second step
In material, load fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 60 DEG C is obtained
Moist powder；4th step, adds dextrin in moist powder, is dried, filling dress capsule, makes capsule.
Embodiment 11
The first step, weighs Radix Angelicae Sinensis 28g, Rhizoma Chuanxiong 15g, Poria 18g, Cortex Cinnamomi 15g, Radix Rehmanniae Preparata 20g, Radix Codonopsis 22g, Radix Glycyrrhizae 13g,
Radix Paeoniae Alba 13g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 16g, Fructus Corni 14g, Rhizoma Dioscoreae 15g, Fructus Schisandrae Chinensis 16g, Fructus Alpiniae Oxyphyllae 13g, Fructus Jujubae 16g, Radix Salviae Miltiorrhizae
15g, Radix Adenophorae (Radix Glehniae) 15g, Hippocampus 16g, Fructus Lycii 18g, Radix Polygalae 16g, Gecko 24g, Radix Ginseng 13g, Rhizoma Polygonati 16g, Carapax et Plastrum Testudiniss 15g, Semen sesami Niger
15g, Herba Epimedii 20g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, by yeast, the common 26.3g of bacillus bifiduss
It is added in fermentation raw material, loads fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, at 60 DEG C
Extract at low temperature, obtains moist powder；4th step, adds starch in moist powder, is dried, makes powder.
Instructions of taking：In the present invention, all kinds of medicament instructions of taking are as follows：Tablet and pill：Three times a day, one after each meal, often
Secondary two panels, 0.5 gram of every content of dispersion；Capsule：Three times a day, one after each meal, two every time, 0.5 gram of every content of dispersion；Dissipate
Agent：Three times a day, one after each meal, each takes a bag, often comprising dose 0.5g；Granule：Three times a day, one after each meal, often
It is secondary to take two, every content of dispersion 0.5g.
Beneficial effects of the present invention are further illustrated below in conjunction with clinical data and model case.
Clinical observation
1st, clinical data：Selected from outpatient service and the inpatient totally 132 in January, 2013 in June, 2014, wherein early stage palace
Neck cancer 25.Age is 46～64 years old, 57.3 years old mean age.There are 98 to be presented with insufficiency of vital energy and blood in wherein 132 patients.
2nd, Therapeutic Method：The granule that the embodiment of the present invention 3 is prepared is taken, is divided early, middle and late three times and is taken, every time
Two.It is within one month a course for the treatment of.
3rd, efficacy assessment standard：According to Ministry of Public Health《Chinese common cancer diagnosis and treatment specification》Cervical cancer efficacy evaluation mark
Standard, with before patient's treatment with treatment after B ultrasonic or CT compared, with complete incidence graph, part alleviation, stably carry out curative effect and comment
It is fixed.
4th, therapeutic effect：Complete incidence graph 95, part alleviate 24, stablize 13.Effective percentage is (complete incidence graph+part
Alleviate) it is 90.1%, coefficient of stabilization (alleviate+stablize in complete incidence graph+part) is 100%.Have 19 in 25 cervical cancers of early stage simultaneously
Example cures (tumor all disappears, and follow-up is not recurred for 1 year).There are 89 patients to be greatly improved in 98 insufficiency of vital energy and blood patients,
Prove that the Chinese medicine composition that the present invention is prepared has good therapeutic effect to insufficiency of vital energy and blood symptom cervical cancer.
5th, side effect analysis
In 132 patients of observation, only have 3 in taking Chinese medicine of the present invention and stomach discomfort, 1 laxativeness occur, go out
The probability of existing side reaction is only 3.03%, and remaining is without any side effects.
Equally according to clinical verification, patient takes other embodiments of the invention dosage form also with same therapeutic effect.
Clinical case
Case 1, female, 53 years old.Patient's abnormal vaginal bleeding four months, Jing examination in hospital are diagnosed as cervical cancer early stage.
In western medical treatment and chemotherapy process, nausea and vomiting, inappetence, and have the symptom appearance of insufficiency of vital energy and blood, stop treatment.Clothes
Two courses for the treatment of of capsule prepared with the embodiment of the present invention 5, chest and abdomen swelling and pain mitigate, and vaginal hemorrhage is reduced, and insufficiency of vital energy and blood symptom is obtained
To improvement.Continue to take three courses for the treatment of of capsule, chest and abdomen swelling and pain, vaginal hemorrhage and insufficiency of vital energy and blood symptom disappear substantially.Swell on inspection
Tumor disappears.Follow-up is not recurred for 1 year.
Case 2, female, 47 years old.Patient's abnormal vaginal bleeding 1 year, Jing examination in hospital are diagnosed as cervical cancer mid-term, and row is put
After treating five courses for the treatment of, the state of an illness does not improve, lower abdominal distention pain, and causes patients blood not enough.Take the glue of the preparation of the embodiment of the present invention 2
After three courses for the treatment of of capsule, symptom takes a turn for the better, and lower abdomen pain mitigates, and insufficiency of vital energy and blood symptom is improved.Continue to take 5 courses for the treatment of of capsule,
Symptom disappears substantially.
Case 3, female, 52 years old.Patient's abnormal vaginal bleeding 4 months, Jing examination in hospital are diagnosed as cervical cancer early stage, patient
The aggravation Jing after two courses for the treatment of of chemotherapy, sagging distention in the smaller abdomen pain, Jing take two courses for the treatment of of capsule of the preparation of the embodiment of the present invention seven
Afterwards, cervix uteri does not occur bleeding again, and after continuing two courses for the treatment of of medication, symptom disappears, and recovers normal.
In sum, the Chinese medicine composition for treating cervical cancer of the invention has effective inhibitory action to cervical cancer,
And without obvious toxic-side effects.
Description of the invention is not exhaustively or limits the invention to disclosed form.Wherein many modifications and
Change is obvious for the ordinary skill in the art, before without departing from the technical scheme described in claim
Put also other deformations.
Claims (10)
1. a kind of Chinese medicine composition, including the raw material of following weight portion：4～36 parts of Radix Angelicae Sinensis, 3～25 parts of Rhizoma Chuanxiong, Poria 4～30
Part, 3～25 parts of Cortex Cinnamomi, 8～28 parts of Radix Rehmanniae Preparata, 6～32 parts of Radix Codonopsis, 5～25 parts of Radix Glycyrrhizae, 3～25 parts of the Radix Paeoniae Alba, 8～28 parts of the Rhizoma Atractylodis Macrocephalae,
4～30 parts of the Radix Astragali, 5～25 parts of Fructus Corni, 4～36 parts of Rhizoma Dioscoreae, 4～30 parts of Fructus Schisandrae Chinensis, 3～25 parts of Fructus Alpiniae Oxyphyllae, Fructus Jujubae 6～32
Part, 3～25 parts of Radix Salviae Miltiorrhizae, 3～25 parts of Radix Adenophorae (Radix Glehniae), 8～28 parts of Hippocampus, 4～36 parts of Fructus Lycii, 4～32 parts of Radix Polygalae, 6～32 parts of Gecko, people
3～25 parts of ginseng, 5～25 parts of Rhizoma Polygonati, 3～25 parts of Carapax et Plastrum Testudiniss, 3～25 parts of Semen sesami Niger, 6～32 parts of Herba Epimedii.
2. Chinese medicine composition according to claim 1, it is characterised in that including the raw material of following weight portion：Radix Angelicae Sinensis 12～28
Part, 12～16 parts of Rhizoma Chuanxiong, 15～20 parts of Poria, 12～16 parts of Cortex Cinnamomi, 14～22 parts of Radix Rehmanniae Preparata, 14～24 parts of Radix Codonopsis, Radix Glycyrrhizae 12
～18 parts, 12～16 parts of the Radix Paeoniae Alba, 14～22 parts of the Rhizoma Atractylodis Macrocephalae, 15～20 parts of the Radix Astragali, 12～18 parts of Fructus Corni, 12～28 parts of Rhizoma Dioscoreae, five
15～20 parts of taste, 12～16 parts of Fructus Alpiniae Oxyphyllae, 14～24 parts of Fructus Jujubae, 12～16 parts of Radix Salviae Miltiorrhizae, 12～16 parts of Radix Adenophorae (Radix Glehniae), Hippocampus 14～22
Part, 12～28 parts of Fructus Lycii, 12～24 parts of Radix Polygalae, 14～24 parts of Gecko, 12～16 parts of Radix Ginseng, 12～18 parts of Rhizoma Polygonati, Carapax et Plastrum Testudiniss 12～
16 parts, 12～16 parts of Semen sesami Niger, 14～24 parts of Herba Epimedii.
3. Chinese medicine composition according to claim 2, it is characterised in that including the raw material of following weight portion：20 parts of Radix Angelicae Sinensis, river
14 parts of rhizome of chuanxiong, 17 parts of Poria, 14 parts of Cortex Cinnamomi, 18 parts of Radix Rehmanniae Preparata, 19 parts of Radix Codonopsis, 15 parts of Radix Glycyrrhizae, 14 parts of the Radix Paeoniae Alba, 18 parts of the Rhizoma Atractylodis Macrocephalae, the Radix Astragali
17 parts, 15 parts of Fructus Corni, 20 parts of Rhizoma Dioscoreae, 17 parts of Fructus Schisandrae Chinensis, 14 parts of Fructus Alpiniae Oxyphyllae, 19 parts of Fructus Jujubae, 14 parts of Radix Salviae Miltiorrhizae, 14 parts of Radix Adenophorae (Radix Glehniae), sea
18 parts of horse, 20 parts of Fructus Lycii, 18 parts of Radix Polygalae, 19 parts of Gecko, 14 parts of Radix Ginseng, 15 parts of Rhizoma Polygonati, 14 parts of Carapax et Plastrum Testudiniss, 14 parts of Semen sesami Niger, excessive sheep
19 parts of the leaves of pulse plants.
4. the Chinese medicine composition according to any one of claims 1 to 3, it is characterised in that the Chinese medicine composition makes medicine
Acceptable preparation on.
5. Chinese medicine composition according to claim 4, it is characterised in that the preparation is tablet, capsule, pill, granule
Or any one in powder.
6. the preparation method of Chinese medicine composition described in a kind of claim 4, it is characterised in that comprise the following steps：The first step, presses
Weight portion weigh Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata, Radix Codonopsis, Radix Glycyrrhizae, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Fructus Corni, Rhizoma Dioscoreae, five
Taste, Fructus Alpiniae Oxyphyllae, Fructus Jujubae, Radix Salviae Miltiorrhizae, Radix Adenophorae (Radix Glehniae), Hippocampus, Fructus Lycii, Radix Polygalae, Gecko, Radix Ginseng, Rhizoma Polygonati, Carapax et Plastrum Testudiniss, Semen sesami Niger, Herba Epimedii,
Crush, sieve, mix homogeneously obtains fermentation raw material；Second step, strain is added in fermentation raw material, loads and send out after stirring
Fermentation tank is fermented；3rd step, at 33～40 DEG C, ferments 8～12 days, and extract at low temperature at 20～60 DEG C obtains moist powder；
4th step, adds adjuvant, is dried, makes pharmaceutically acceptable preparation.
7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in second step, the strain is honeybee
Honey or probiotic bacteria.
8. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that the weight of the Mel and fermentation raw material
Amount ratio is 1～2:1, probiotic bacteria is 0.05～0.1 with the weight ratio of fermentation raw material:1.
9. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in the 3rd step, at 37 DEG C,
Fermentation 10 days, the extract at low temperature at 45 DEG C obtains moist powder.
10. application of the arbitrary Chinese medicine composition of claims 1 to 3 in treatment cervix uteri cancer drug is prepared.
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| CN111184835A (en) * | 2020-04-09 | 2020-05-22 | 喻小兰 | A pharmaceutical composition prepared from baicalein for treating cervical cancer |
| CN111643625A (en) * | 2020-07-18 | 2020-09-11 | 王国辉 | Traditional Chinese medicine composition and application thereof |
| CN115918852A (en) * | 2022-12-28 | 2023-04-07 | 金华市食品药品检验检测研究院 | Kidney-tonifying and spleen-invigorating paste and preparation method thereof |
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