CN106692871A

CN106692871A - Traditional Chinese medicine composition, preparation method thereof and application of traditional Chinese medicine composition in liver cancer treatment

Info

Publication number: CN106692871A
Application number: CN201611121063.8A
Authority: CN
Inventors: 吴蓓莉
Original assignee: Shenzhen City Dedao Chinese Medicine Museum Management LLC
Current assignee: Shenzhen City Dedao Chinese Medicine Museum Management LLC
Priority date: 2016-09-21
Filing date: 2016-12-08
Publication date: 2017-05-24

Abstract

The invention discloses a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in liver cancer treatment. The traditional Chinese medicine composition is prepared from the following raw materials: herba leonuri, leech, rhizoma galangae, gadfly, rhizoma corydalis, frankincense, ferula asafoetida, radix rehmanniae praeparata, safflower carthamus, angelica sinensis, rhizoma cyperi, rhizoma curcumae longae, rheum officinale, peach kernels, turtle shell, radix paeoniae alba, resina toxicodendri, caesalpinia sappan, ligusticum wallichii, ginseng, myrrh, fructus perillae, trogopterus dung, pollen typhae, fructus evodiae, astragalus membranaceus, licorice roots, common camptotheca fruits, pangolin scale and toad. According to the traditional Chinese medicine composition, the raw materials are synergized to achieve the effects of inhibiting or killing cancer cells, softening and reducing tumors and eliminating cancer, have remarkable liver cancer treatment effect, and do not have toxic or side effect on human bodies. The traditional Chinese medicinal ingredient prepared by adopting the fermenting method are subjected to solid fermentation to change big molecules into small molecules, and can be absorbed by a human body by 100 percent, so that the curative effect can be improved; taste of the traditional Chinese medicine can be improved by adding honey.

Description

A kind of application of Chinese medicine composition and preparation method thereof and treatment liver cancer

Technical field

The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method thereof should with treatment liver cancer With.

Background technology

Industrialized development has promoted the advance of society and the progress of the mankind, while the problems such as also bringing environmental pollution, People are influenceed by factors such as chemistry, physics, biologies, and the incidence of disease more and more higher of cancer, wherein liver cancer are common China One of malignant tumour, the death rate is high, be only second in mortality of malignant tumors cis-position stomach cancer, cancer of the esophagus and occupy the 3rd.It is right In the treatment of liver cancer, mainly operative treatment, radiation and chemotherapy are taken on modern medicine.Operative treatment is that cancer does not occur to early stage Transcellular cancer patient reaches the method cured or control cancer by removal of lesions position.Radiotherapy is penetrated using high energy Cancer cell is killed in the irradiation of line, but human normal cell is subject to a certain degree of damage while cancer cell is killed.Chemotherapy is Treated using chemicals, whole body to is taken medicine by blood circulation and all cells of body are acted on, killed cancer thin Born of the same parents can also kill human normal cell simultaneously.

Either use operative treatment, chemotherapy or radiotherapy, can all cause great vigour to damage to patient, at the same radiotherapy or The problems such as chemotherapy may result in body immunity decline, poor appetite.Because there is traditional Chinese medicine anticancer to press down swollen, toxic and side effect Small the features such as, is increasingly subject to the concern of people.Traditional Chinese medicine typically using in extracting medicinal material in method that family boils it is effective into Point, but family boils time of Chinese medicine, temperature, pressure and is difficult to unify, therefore, it is difficult to the active ingredient for determining to be extracted in medicinal material Content；Decoction or Chinese patent drug that patient takes, it is necessary to the probiotics for passing through human body gastrointestinal system is digested and is decomposed again, ability It is converted into the final active ingredient for working and enters blood, if the flora of probiotics is unbalance in patient's gastrointestinal system, medicine Composition effectively can not be decomposed and then be absorbed by the body, then medicine cannot reach its due curative effect.

The content of the invention

A kind of deficiency that the present invention exists for the present situation and traditional Chinese medicine of existing western medical treatment liver cancer, there is provided Chinese medicine Composition and preparation method thereof, active ingredient changes into small molecule and is easily absorbed by the body in the Chinese medicine composition for preparing, It is evident in efficacy.

The present invention provide Chinese medicine composition, including following weight portion raw material：10~40 parts of motherwort, leech 5~25 Part, 6~32 parts of galangal, 3~15 parts of gadfly, 10~40 parts of corydalis tuber, 8~28 parts of frankincense, 6~32 parts of asafoetide, prepared rhizome of rehmannia 8~ 28 parts, 12~32 parts of safflower, 10~40 parts of Radix Angelicae Sinensis, 6~32 parts of rhizoma cyperi, 10~40 parts of turmeric, 8~28 parts of rheum officinale, peach kernel 12~ 32 parts, 3~25 parts of turtle shell, 10~40 parts of the root of herbaceous peony, 3~15 parts of dried lacquer, 8~28 parts of bush, 6~32 parts of Ligusticum wallichii, ginseng 3~25 Part, 3~15 parts of myrrh, 8~28 parts of perilla seed, 10~40 parts of excrementum pteropi, 12~32 parts of cattail pollen, 6~32 parts of evodia rutaecarpa, the Radix Astragali 10 ~40 parts, 8~28 parts of Radix Glycyrrhizae, 6~32 parts of Common Camptotheca Fruit, 3~15 parts of pangolin, 3~15 parts of toad.

Preferably, Chinese medicine composition of the present invention, including following weight portion raw material：22~28 parts of motherwort, leech 12~18 parts, 16~22 parts of galangal, 6~12 parts of gadfly, 22~28 parts of corydalis tuber, 14~22 parts of frankincense, 16~22 parts of asafoetide, 14~22 parts of prepared rhizome of rehmannia, 18~26 parts of safflower, 22~28 parts of Radix Angelicae Sinensis, 16~22 parts of rhizoma cyperi, 22~28 parts of turmeric, rheum officinale 14~22 Part, 18~26 parts of peach kernel, 9~19 parts of turtle shell, 22~28 parts of the root of herbaceous peony, 6~12 parts of dried lacquer, 14~22 parts of bush, Ligusticum wallichii 16~22 Part, 9~19 parts of ginseng, 6~12 parts of myrrh, 14~22 parts of perilla seed, 22~28 parts of excrementum pteropi, 18~26 parts of cattail pollen, evodia rutaecarpa 16~22 parts, 22~28 parts of the Radix Astragali, 14~22 parts of Radix Glycyrrhizae, 16~22 parts of Common Camptotheca Fruit, 6~12 parts of pangolin, 6~12 parts of toad.

It is optimal, Chinese medicine composition of the present invention, including following weight portion raw material：25 parts of motherwort, 15 parts of leech, Gao Liang 19 parts of ginger, 9 parts of gadfly, 25 parts of corydalis tuber, 18 parts of frankincense, 19 parts of asafoetide, 18 parts of prepared rhizome of rehmannia, 22 parts of safflower, 25 parts of Radix Angelicae Sinensis, rhizoma cyperi 19 parts, 25 parts of turmeric, 18 parts of rheum officinale, 22 parts of peach kernel, 14 parts of turtle shell, 25 parts of the root of herbaceous peony, 9 parts of dried lacquer, 18 parts of bush, 19 parts of Ligusticum wallichii, 14 parts of ginseng, 9 parts of myrrh, 18 parts of perilla seed, 25 parts of excrementum pteropi, 22 parts of cattail pollen, 19 parts of evodia rutaecarpa, 25 parts of the Radix Astragali, 18 parts of Radix Glycyrrhizae, 19 parts of Common Camptotheca Fruit, 9 parts of pangolin, 9 parts of toad.

Chinese medicine composition of the present invention is made pharmaceutically acceptable preparation.

The preparation is any one in tablet, capsule, granule, powder or pill.

The preparation method of the Chinese medicine composition, comprises the following steps：The first step, weigh by weight motherwort, leech, Galangal, gadfly, corydalis tuber, frankincense, asafoetide, prepared rhizome of rehmannia, safflower, Radix Angelicae Sinensis, rhizoma cyperi, turmeric, rheum officinale, peach kernel, turtle shell, the root of herbaceous peony, Dried lacquer, bush, Ligusticum wallichii, ginseng, myrrh, perilla seed, excrementum pteropi, cattail pollen, evodia rutaecarpa, the Radix Astragali, Radix Glycyrrhizae, Common Camptotheca Fruit, pangolin, toad Bufonid toad, crushes, and sieving is well mixed to obtain fermentation raw material；Second step, strain is added in fermentation raw material, is filled after stirring Enter fermentation tank to be fermented；3rd step, at 33~40 DEG C, is fermented 8~12 days, and low temperature is extracted at 20~60 DEG C, obtains humidity Powder；4th step, adds auxiliary material, is made pharmaceutically acceptable preparation.

In second step, the strain is honey or probiotics.

Further, the honey and the part by weight of fermentation raw material are 1~2：1, the probiotics and fermentation raw material Part by weight is 0.05~0.1:1.

Further, the probiotics be lactic acid bacteria, Bifidobacterium, saccharomycete in one or two.

In 3rd step, at 37 DEG C, ferment 10 days, low temperature is extracted at 45 DEG C, obtains moist powder.

The invention further relates to application of the Chinese medicine composition in treatment liver-cancer medicine is prepared.

, wherein it is desired to explanation, for realizing the purpose of the present invention, Chinese medicine composition of the invention is not limited to Above-mentioned preparation method, present invention only provides a kind of specific preparation method.

Chinese medicine composition of the present invention, selected herbal nature is described below：

Motherwort, taste is pungent is bitter, cool in nature, with promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, inducing diuresis to remove edema, clearing heat and detoxicating effect, cures mainly Irregular menstruation, dysmenorrhoea, Amenorrhea, Hypomenorrhea, postpartum anemic fainting, abdominalgia with blood stasis, nephralgia oedema, difficult urination, hematuria etc..

Leech, it is bitter, salty, it is mild-natured, with promoting blood circulation and breaking stagnation, disperse accumulations of stimulating the menstrual flow, cure mainly stasis amenorrhoea, traumatic stasis, Disorder lumps in the abdomen product The illness such as poly-.

Galangal, taste is pungent, property heat, with dispelling cold, stomach invigorating and analgesic effect, mainly treating intolerance of cold is had a pain, vomits gas.

Gadfly, bitter is cool in nature, have functions that blood-breaking stimulate the menstrual flow, Zhu Yu Xiao Disorder, cure mainly blood stasis is through closing, prolonged lochia, A type of tubercular disease found in women, few abdomen store Xue, Disorder lump in the abdomen product block, injuries from falls as well, carbuncle swells, larynx numbness.

Corydalis tuber, taste is pungent, hardship are warm in nature, have functions that promoting blood circulation to remove blood stasis, promoting qi circulation and relieving pain, cure mainly headache, pain in the back, muscle and bone ache, Dysmenorrhoea, Amenorrhea, traumatic injury.

Frankincense, taste is pungent, hardship are warm in nature, have functions that promoting blood circulation analgesic therapy, detumescence and promoting granulation, cure mainly dysmenorrhoea, amenorrhoea, gastral cavity pain, Arthralgia pain due to rheumatism, injuries from falls as well, ulcer sore pain etc..

Asafoetide, taste is pungent, hardship are warm in nature, have functions that disperse accumulations, dissipate ruffian, desinsection, in curing mainly meat stagnation, hemostasis note of the ancient Chinese lump in the abdomen, abdomen Lump in the abdomen, abdominal pain due to enterositosis.

Prepared rhizome of rehmannia, sweet, slightly warm in nature has functions that nourishing yin and supplementing blood, beneficial to spirit and marrow, cure mainly the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, Osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, beard and hair It is early white.

Safflower, taste is pungent is warm in nature, has functions that invigorate blood circulation, blood stasis removing analgesic, cures mainly Amenorrhea, dysmenorrhoea, traumatic injury.

Radix Angelicae Sinensis, it is sweet, pungent, it is warm in nature, have functions that to enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly all cards of the deficiency of blood, Irregular menstruation, Amenorrhea, dysmenorrhoea, abdominal mass knot are poly-, uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestines are dry and shit is difficult, weight, carbuncle after dysentery characterized by blood in the stool Subcutaneous ulcer sore, injury from falling down.

Rhizoma cyperi, it is sweet, it is mild-natured, there are regulating the flow of vital energy Xie Yu, menstruction regulating and pain relieving.

Turmeric, taste is pungent, hardship are warm in nature, have functions that blood-breaking, promoting the circulation of qi, stimulate the menstrual flow, relieve pain, and cure mainly trusted subordinate's feeling of fullness distending pain, arm Bitterly, abdominal mass, women's blood stasis is through closing, the postpartum stasis of blood stop stomachache, injury from falling down, carbuncle swells.

Rheum officinale, bitter is cold in nature, the poison that has functions that to purge heat, broken stagnant, row hemostasis, cure mainly real heat constipation, delirious speech hair support, Dyspepsia feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menopause Bi, lumps in the chest and abdomen, when row hot epidemic disease, sudden and violent swelling ophthalmalgia, haematemesis, bleeding from five sense organs or subcutaneous tissue, sun Huang, oedema, stranguria with turbid discharge, urinate also, large carbuncle pyogenic infections, furunculosis, burn.

Peach kernel, it is bitter, sweet, it is mild-natured, with promoting blood circulation, relax bowel, relieving cough and asthma effect, cure mainly closed dysmenorrhea, Wei lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.

Turtle shell, taste is salty, cold nature, has functions that nourishing and suppressing Yang, brings down a fever except steaming, softening and resolving hard mass, cures mainly fever due to yin deficiency, bone Steam labor heat, hyperactivity of yang due to yin deficiency, have a dizzy spell, endogenous deficient wind, Amenorrhea, Disorder lumps in the abdomen, chronic malaria, malaria mother.

The root of herbaceous peony, bitter, acid, cold nature has functions that to enrich blood, holds back cloudy soft liver, relieving spasm to stop pain, cures mainly dizziness of having a headache, the side of body Bitterly, stomachache, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.

Dried lacquer, taste is pungent is warm in nature, has functions that broken stasis of blood blood, disperse accumulations, desinsection, cures mainly amenorrhoea, hemostasis abdominal mass, abdominal pain due to enterositosis.

Bush, it is sweet, salty, it is cool in nature, there is promoting blood circulation, detumescence ding-tong, cure mainly amenorrhea due to stagnation of blood, dysmenorrhoea, postpartum Stasis blocking pain in the chest and abdomen, postpartum anemic fainting, carbuncle swells, traumatic injury, lockjaw.

Ligusticum wallichii, taste is pungent is warm in nature, with promote breath and open depression, dispels pathogenic wind and remove dampness, effect of promoting blood circulation and stopping pain, cure mainly air-cooled headache rotation it is dizzy, Hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores.

Ginseng, sweet, slight bitter is warm in nature, flat, returns spleen, lung, the heart channel of Hang-Shaoyin, with tonifying Qi, take off admittedly, promote the production of body fluid, calming the nerves, the work(of intelligence development Effect, cure mainly it is physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung are breathed with cough, injury thirst, Heat Diabetes, prolonged illness void are thin, palpitation with fear is lost Dormancy, impotence Gong Leng, heart failure, cardiogenic shock.

Myrrh, taste is pungent, hardship are mild-natured, have functions that scattered stasis pain, detumescence and promoting granulation, cure mainly chest impediment and cardialgia, gastral cavity pain, Dysmenorrhoea Amenorrhea, postpartum stasis, Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore etc..

Perilla seed, taste is pungent is warm in nature, have functions that sending down abnormally ascending dissolving phlegm, relieving asthma, ease constipation, cure mainly phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma, Dry constipation of intestines.

Excrementum pteropi, it is sweet, it is warm in nature, there are promoting blood circulation to remove blood stasis, fries charcoal hemostasis, cure mainly trusted subordinate's extravasated blood, dysmenorrhoea, blood Traumatic injury, snake, insect bite are controlled in stasis of blood Amenorrhea, curing postpartum bleeding is suffered from abdominal pain, Fry charcoal and control metrostaxis, external application.

Cattail pollen, it is sweet, it is mild-natured, with hemostasia and dissipation blood stasis, treating stranguria effect, cure mainly haematemesis, bleeding from five sense organs or subcutaneous tissue, spitting of blood, uterine bleeding, wound and go out Blood, Amenorrhea are stimulated the menstrual flow, chest and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.

Evodia rutaecarpa, taste is pungent, hardship, property heat is slightly poisonous, the effect of with eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.

The Radix Astragali, sweet, slightly warm in nature, return lung, spleen, liver and kidney channel, with invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation Effect, cure mainly treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, the deficiency of vital energy oedema Radix Astragali Disk, ulcer is difficult to burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes.

Radix Glycyrrhizae, it is sweet, it is mild-natured, with invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription work( Effect, cures mainly weakness of the spleen and the stomach, deficiency of food, stomachache loose stool, overstrain heating, consumptive lung disease cough, palpitaition, frightened epilepsy, abscess of throat, digestibility routed Ulcer, ulcer sores, medicine poison and food poisoning.

Common Camptotheca Fruit, it is bitter, puckery, it is cold in nature, there is anticancer, dissipating bind, blood-breaking stagnation resolvation, cure mainly kinds of tumors, stomach cancer, intestines Cancer, chorioepithelioma, lymphosarcoma etc..

Pangolin, taste is salty, cold nature, have functions that blood circulation promoting and dispersing pathogen accumulation, stimulate the menstrual flow it is lower breast, anti-stain in solid, cure mainly blood stasis is through closing, Abdominal mass, arthralgia pain due to rheumatism, agalactia, carbuncle swells, scrofula.

Toad, be it is pungent, it is cool in nature, there is detoxicating and resolving a mass, disperse accumulations Li Shui, destroying parasites for curing malnutrition, cure mainly dysentery subcutaneous ulcer, furunculosis, hair The back of the body, scrofula, evil sore, the abdominal mass hypochondriac lump, expansion, oedema, infantile malnutrition, lockjaw, chronic cough and asthma.

Can be acted synergistically between raw material selected by Chinese medicine composition of the present invention, suppress or kill cancer cell, soften contracting Little tumour, eliminates cancer and makes, and human body is had no toxic side effect, and treatment liver cancer efficacy is notable；Using fermentation process system of the present invention The standby Chinese medicine composition for obtaining becomes small molecule by solid state fermentation by macromolecular, can be absorbed by the body with 100%, improves Curative effect, while the addition of honey improves Chinese medicine taste.

Specific embodiment

In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment pair The present invention is further described.It should be appreciated that specific embodiment described herein is only used to explain the present invention, but simultaneously It is not used in the restriction present invention.

Embodiment 1

The first step, weighs motherwort 10g, leech 5g, galangal 6g, gadfly 3g, corydalis tuber 10g, frankincense 8g, asafoetide 6g, Prepared rhizome of rehmannia 8g, safflower 12g, Radix Angelicae Sinensis 10g, rhizoma cyperi 6g, turmeric 10g, rheum officinale 8g, peach kernel 12g, turtle shell 3g, root of herbaceous peony 10g, dried lacquer 3g, Bush 8g, Ligusticum wallichii 6g, ginseng 3g, myrrh 3g, perilla seed 8g, excrementum pteropi 10g, cattail pollen 12g, evodia rutaecarpa 6g, Radix Astragali 10g, Radix Glycyrrhizae 8g, Common Camptotheca Fruit 6g, pangolin 3g, toad 3g, crush, and sieving is well mixed to obtain fermentation raw material；Second step, by honey 216g It is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 33 DEG C, ferments 12 days, at 20 DEG C Low temperature is extracted, and obtains moist powder；4th step, moist powder is dried, and adds dextrin, compressing tablet to be made tablet.

Embodiment 2

The first step, weighs motherwort 40g, leech 25g, galangal 32g, gadfly 15g, corydalis tuber 40g, frankincense 28g, asafoetide 32g, prepared rhizome of rehmannia 28g, safflower 32g, Radix Angelicae Sinensis 40g, rhizoma cyperi 32g, turmeric 40g, rheum officinale 28g, peach kernel 32g, turtle shell 25g, the root of herbaceous peony 40g, dried lacquer 15g, bush 28g, Ligusticum wallichii 32g, ginseng 25g, myrrh 15g, perilla seed 28g, excrementum pteropi 40g, cattail pollen 32g, Wu Zhu Cornel 32g, Radix Astragali 40g, Radix Glycyrrhizae 28g, Common Camptotheca Fruit 32g, pangolin 15g, toad 15g, crush, and sieving is well mixed to be fermented Raw material；Second step, honey 900g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, At 35 DEG C, ferment 11 days, low temperature is extracted at 25 DEG C, obtains moist powder；4th step, moist powder is dried, and adds starch, system Into pill.

Embodiment 3

The first step, weighs motherwort 25g, leech 15g, galangal 19g, gadfly 9g, corydalis tuber 25g, frankincense 18g, asafoetide 19g, prepared rhizome of rehmannia 18g, safflower 22g, Radix Angelicae Sinensis 25g, rhizoma cyperi 19g, turmeric 25g, rheum officinale 18g, peach kernel 22g, turtle shell 14g, the root of herbaceous peony 25g, dried lacquer 9g, bush 18g, Ligusticum wallichii 19g, ginseng 14g, myrrh 9g, perilla seed 18g, excrementum pteropi 25g, cattail pollen 22g, evodia rutaecarpa 19g, Radix Astragali 25g, Radix Glycyrrhizae 18g, Common Camptotheca Fruit 19g, pangolin 9g, toad 9g, crush, and sieving is well mixed to obtain fermentation raw material； Second step, honey 828g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 37 DEG C Under, fermenting 10 days, low temperature is extracted at 45 DEG C, obtains moist powder；4th step, adds dextrin, drying of pelletizing, and is made granule.

Embodiment 4

The first step, weighs motherwort 22g, leech 12g, galangal 16g, gadfly 6g, corydalis tuber 22g, frankincense 14g, asafoetide 16g, prepared rhizome of rehmannia 14g, safflower 18g, Radix Angelicae Sinensis 22g, rhizoma cyperi 16g, turmeric 22g, rheum officinale 14g, peach kernel 18g, turtle shell 9g, root of herbaceous peony 22g, Dried lacquer 6g, bush 14g, Ligusticum wallichii 16g, ginseng 9g, myrrh 6g, perilla seed 14g, excrementum pteropi 22g, cattail pollen 18g, evodia rutaecarpa 16g, it is yellow Stilbene 22g, Radix Glycyrrhizae 14g, Common Camptotheca Fruit 16g, pangolin 6g, toad 6g, crush, and sieving is well mixed to obtain fermentation raw material；Second Step, honey 716g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 38 DEG C, hair Ferment 9 days, low temperature is extracted at 50 DEG C, obtains moist powder；4th step, moist powder is dried, and adds starch, is made powder.

Embodiment 5

The first step, weighs motherwort 28g, leech 18g, galangal 22g, gadfly 12g, corydalis tuber 28g, frankincense 22g, asafoetide 22g, prepared rhizome of rehmannia 22g, safflower 26g, Radix Angelicae Sinensis 28g, rhizoma cyperi 22g, turmeric 28g, rheum officinale 22g, peach kernel 26g, turtle shell 19g, the root of herbaceous peony 28g, dried lacquer 12g, bush 22g, Ligusticum wallichii 22g, ginseng 19g, myrrh 12g, perilla seed 22g, excrementum pteropi 28g, cattail pollen 26g, Wu Zhu Cornel 22g, Radix Astragali 28g, Radix Glycyrrhizae 22g, Common Camptotheca Fruit 22g, pangolin 12g, toad 12g, crush, and sieving is well mixed to be fermented Raw material；Second step, honey 850g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, At 40 DEG C, ferment 8 days, low temperature is extracted at 55 DEG C, obtains moist powder；4th step, moist powder is dried, and adds starch, system Into powder.

Embodiment 6

The first step, weighs motherwort 28g, leech 16g, galangal 17g, gadfly 7g, corydalis tuber 23g, frankincense 20g, asafoetide 21g, prepared rhizome of rehmannia 17g, safflower 20g, Radix Angelicae Sinensis 26g, rhizoma cyperi 18g, turmeric 24g, rheum officinale 19g, peach kernel 21g, turtle shell 17g, the root of herbaceous peony 26g, dried lacquer 7g, bush 17g, Ligusticum wallichii 18g, ginseng 12g, myrrh 8g, perilla seed 15g, excrementum pteropi 26g, cattail pollen 23g, evodia rutaecarpa 20g, Radix Astragali 26g, Radix Glycyrrhizae 19g, Common Camptotheca Fruit 21g, pangolin 7g, toad 7g, crush, and sieving is well mixed to obtain fermentation raw material； Second step, honey 764g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 40 DEG C Under, fermenting 8 days, low temperature is extracted at 60 DEG C, obtains moist powder；4th step, moist powder is dried, and adds starch, is made ball Agent.

Embodiment 7

The first step, weighs motherwort 19g, leech 9g, galangal 15g, gadfly 4g, corydalis tuber 21g, frankincense 13g, asafoetide 15g, prepared rhizome of rehmannia 13g, safflower 17g, Radix Angelicae Sinensis 20g, rhizoma cyperi 15g, turmeric 13g, rheum officinale 13g, peach kernel 17g, turtle shell 7g, root of herbaceous peony 21g, Dried lacquer 5g, bush 13g, Ligusticum wallichii 15g, ginseng 7g, myrrh 6g, perilla seed 13g, excrementum pteropi 21g, cattail pollen 17g, evodia rutaecarpa 15g, it is yellow Stilbene 21g, Radix Glycyrrhizae 14g, Common Camptotheca Fruit 16g, pangolin 4g, toad 4g, crush, and sieving is well mixed to obtain fermentation raw material；Second Step, honey 806g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 40 DEG C, hair Ferment 8 days, low temperature is extracted at 45 DEG C, obtains moist powder；4th step, moist powder is dried, and adds dextrin to dry, filling dress Capsule, is made capsule.

Embodiment 8

The first step, weighs motherwort 29g, leech 17g, galangal 23g, gadfly 13g, corydalis tuber 29g, frankincense 23g, asafoetide 23g, prepared rhizome of rehmannia 24g, safflower 23g, Radix Angelicae Sinensis 26g, rhizoma cyperi 25g, turmeric 29g, rheum officinale 25g, peach kernel 27g, turtle shell 20g, the root of herbaceous peony 29g, dried lacquer 14g, bush 23g, Ligusticum wallichii 24g, ginseng 20g, myrrh 14g, perilla seed 24g, excrementum pteropi 30g, cattail pollen 25g, Wu Zhu Cornel 25g, Radix Astragali 32g, Radix Glycyrrhizae 26g, Common Camptotheca Fruit 23g, pangolin 12g, toad 12g, crush, and sieving is well mixed to be fermented Raw material；Second step, honey 758g is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, At 40 DEG C, ferment 8 days, low temperature is extracted at 45 DEG C, obtains moist powder；4th step, moist powder is dried, and adds dextrin, pressure Piece, is made tablet.

In embodiment 1-8, using honey as strain raw material, the addition of honey can improve Chinese medicine taste.

Embodiment 9

The first step, weighs motherwort 29g, leech 17g, galangal 23g, gadfly 13g, corydalis tuber 29g, frankincense 23g, asafoetide 23g, prepared rhizome of rehmannia 24g, safflower 23g, Radix Angelicae Sinensis 26g, rhizoma cyperi 25g, turmeric 29g, rheum officinale 25g, peach kernel 27g, turtle shell 20g, the root of herbaceous peony 29g, dried lacquer 14g, bush 23g, Ligusticum wallichii 24g, ginseng 20g, myrrh 14g, perilla seed 24g, excrementum pteropi 30g, cattail pollen 25g, Wu Zhu Cornel 25g, Radix Astragali 32g, Radix Glycyrrhizae 26g, Common Camptotheca Fruit 23g, pangolin 12g, toad 12g, crush, and sieving is well mixed to be fermented Raw material；Second step, 34.45g lactic acid bacterias are added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd Step, at 40 DEG C, is fermented 8 days, and low temperature is extracted at 45 DEG C, obtains moist powder；4th step, moist powder is dried, and adds paste Essence, compressing tablet is made tablet.

Embodiment 10

The first step, weighs motherwort 19g, leech 9g, galangal 15g, gadfly 4g, corydalis tuber 21g, frankincense 13g, asafoetide 15g, prepared rhizome of rehmannia 13g, safflower 17g, Radix Angelicae Sinensis 20g, rhizoma cyperi 15g, turmeric 13g, rheum officinale 13g, peach kernel 17g, turtle shell 7g, root of herbaceous peony 21g, Dried lacquer 5g, bush 13g, Ligusticum wallichii 15g, ginseng 7g, myrrh 6g, perilla seed 13g, excrementum pteropi 21g, cattail pollen 17g, evodia rutaecarpa 15g, it is yellow Stilbene 21g, Radix Glycyrrhizae 14g, Common Camptotheca Fruit 16g, pangolin 4g, toad 4g, crush, and sieving is well mixed to obtain fermentation raw material；Second Step, 32.24g saccharomycete is added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd step, at 40 DEG C Under, fermenting 8 days, low temperature is extracted at 45 DEG C, obtains moist powder；4th step, moist powder is dried, and adds dextrin to dry, and is filled out Capsule is filled, capsule is made.

Embodiment 11

The first step, weighs motherwort 22g, leech 12g, galangal 16g, gadfly 6g, corydalis tuber 22g, frankincense 14g, asafoetide 16g, prepared rhizome of rehmannia 14g, safflower 18g, Radix Angelicae Sinensis 22g, rhizoma cyperi 16g, turmeric 22g, rheum officinale 14g, peach kernel 18g, turtle shell 9g, root of herbaceous peony 22g, Dried lacquer 6g, bush 14g, Ligusticum wallichii 16g, ginseng 9g, myrrh 6g, perilla seed 14g, excrementum pteropi 22g, cattail pollen 18g, evodia rutaecarpa 16g, it is yellow Stilbene 22g, Radix Glycyrrhizae 14g, Common Camptotheca Fruit 16g, pangolin 6g, toad 6g, crush, and sieving is well mixed to obtain fermentation raw material；Second Step, lactic acid bacteria, the common 44.8g of Bifidobacterium are added in fermentation raw material, fermentation tank is loaded after stirring and is fermented；3rd Step, at 38 DEG C, is fermented 9 days, and low temperature is extracted at 50 DEG C, obtains moist powder；4th step, moist powder is dried, and is added and is formed sediment Powder, is made powder.

Instructions of taking：All kinds of medicament instructions of taking are as follows in the present invention：Tablet and pill：Three times a day, one after each meal, often Secondary two panels, every 0.5 gram of content of dispersion；Capsule：Three times a day, one after each meal, two every time, every 0.5 gram of content of dispersion；Dissipate Agent：Three times a day, one after each meal, each takes a bag, often comprising dose 0.5g；Granule：Three times a day, one after each meal, often It is secondary to take two, every content of dispersion 0.5g.

Beneficial effects of the present invention are further illustrated below in conjunction with clinical data and model case.

Clinical observation

1st, clinical data：It is normal by blood selected from June, 2013 to the outpatient service in December, 2014 and inpatient totally 113 The imageological examinations such as rule inspection, hepatic and renal function inspection and CT, two months are a course for the treatment of, it is more than one course for the treatment of of medication, 78% trouble Person's tumour reduces more than 50%, wherein 45% patient tumors are wholly absent.

2nd, treatment method：Take granule, the pill of the system of embodiment 6 or embodiment that the embodiment of the present invention three is prepared 7 made capsules, divide early, middle and late three times and take, two every time.It is within two months a course for the treatment of.

3rd, efficacy assessment standard：

Complete incidence graph：Cases of complete remission, maintains more than surrounding；

Alleviate part：Tumor regression more than 50%, maintains surrounding；

Stabilization：Tumor regression increases above 25% not as good as 50%；

Deteriorate：Tumour increase more than 25%.

4th, therapeutic effect：Complete incidence graph 65, part alleviates 24, stablizes 13.Total effective rate is (complete incidence graph+portion Divide and alleviate+stabilization) it is 90.2%.

5th, side effect analysis

In 113 patients of observation, take in Chinese medicine of the present invention only 3 occur having a stomach upset, 1 laxativeness, go out The probability of existing side reaction is only 3.5%, and remaining is without any side effects.

Equally according to clinical verification, patient takes other embodiments of the invention formulation also has same therapeutic effect.

Model case

1st, Lee, 53 years old, be the liver cancer initial stage by hospital diagnosis, takes the capsule one obtained by the embodiment of the present invention seven After the course for the treatment of, check again for finding tumor regression more than 50% through hospital, continue to take 2 courses for the treatment of, cases of complete remission recovers just Often.

2nd, Cai, 63 years old, be liver cancer mid-term by hospital diagnosis, takes the granule of the system of the embodiment of the present invention three, three treatments Stable disease after journey, continues taking the two courses, and returns to normal.

3rd, thank certain, 67 years old, by hospital diagnosis be later period of hepatocarcinoma, take the embodiment of the present invention six obtained in pill, take three After the individual course for the treatment of, stable disease continues to take three courses for the treatment of, tumor regression and has no diffusion.

In sum, the present invention has effective inhibitory action, curative effect to liver cancer for treating the Chinese medicine composition of liver cancer Significantly, and without obvious toxic-side effects.

Description of the invention is not exhaustively or limits the invention to disclosed form.Wherein many modifications and Change is for the ordinary skill in the art obvious, before without departing from the technical scheme described in claim Put also other deformations.

Claims

1. a kind of Chinese medicine composition, it is characterised in that the raw material including following weight portion：10~40 parts of motherwort, leech 5~25 Part, 6~32 parts of galangal, 3~15 parts of gadfly, 10~40 parts of corydalis tuber, 8~28 parts of frankincense, 6~32 parts of asafoetide, prepared rhizome of rehmannia 8~ 28 parts, 12~32 parts of safflower, 10~40 parts of Radix Angelicae Sinensis, 6~32 parts of rhizoma cyperi, 10~40 parts of turmeric, 8~28 parts of rheum officinale, peach kernel 12~ 32 parts, 3~25 parts of turtle shell, 10~40 parts of the root of herbaceous peony, 3~15 parts of dried lacquer, 8~28 parts of bush, 6~32 parts of Ligusticum wallichii, ginseng 3~25 Part, 3~15 parts of myrrh, 8~28 parts of perilla seed, 10~40 parts of excrementum pteropi, 12~32 parts of cattail pollen, 6~32 parts of evodia rutaecarpa, the Radix Astragali 10 ~40 parts, 8~28 parts of Radix Glycyrrhizae, 6~32 parts of Common Camptotheca Fruit, 3~15 parts of pangolin, 3~15 parts of toad.

2. Chinese medicine composition according to claim 1, it is characterised in that the raw material including following weight portion：Motherwort 22~ 28 parts, 12~18 parts of leech, 16~22 parts of galangal, 6~12 parts of gadfly, 22~28 parts of corydalis tuber, 14~22 parts of frankincense, asafoetide 16~22 parts, 14~22 parts of prepared rhizome of rehmannia, 18~26 parts of safflower, 22~28 parts of Radix Angelicae Sinensis, 16~22 parts of rhizoma cyperi, 22~28 parts of turmeric, 14~22 parts of rheum officinale, 18~26 parts of peach kernel, 9~19 parts of turtle shell, 22~28 parts of the root of herbaceous peony, 6~12 parts of dried lacquer, 14~22 parts of bush, 16~22 parts of Ligusticum wallichii, 9~19 parts of ginseng, 6~12 parts of myrrh, 14~22 parts of perilla seed, 22~28 parts of excrementum pteropi, cattail pollen 18~26 Part, 16~22 parts of evodia rutaecarpa, 22~28 parts of the Radix Astragali, 14~22 parts of Radix Glycyrrhizae, 16~22 parts of Common Camptotheca Fruit, 6~12 parts of pangolin, toad 6~12 parts.

3. Chinese medicine composition according to claim 2, it is characterised in that the raw material including following weight portion：25 parts of motherwort, 15 parts of leech, 19 parts of galangal, 9 parts of gadfly, 25 parts of corydalis tuber, 18 parts of frankincense, 19 parts of asafoetide, 18 parts of prepared rhizome of rehmannia, 22 parts of safflower, 25 parts of Radix Angelicae Sinensis, 19 parts of rhizoma cyperi, 25 parts of turmeric, 18 parts of rheum officinale, 22 parts of peach kernel, 14 parts of turtle shell, 25 parts of the root of herbaceous peony, 9 parts of dried lacquer, bush 18 Part, 19 parts of Ligusticum wallichii, 14 parts of ginseng, 9 parts of myrrh, 18 parts of perilla seed, 25 parts of excrementum pteropi, 22 parts of cattail pollen, 19 parts of evodia rutaecarpa, the Radix Astragali 25 Part, 18 parts of Radix Glycyrrhizae, 19 parts of Common Camptotheca Fruit, 9 parts of pangolin, 9 parts of toad.

4. the Chinese medicine composition according to any one of claims 1 to 3, it is characterised in that the Chinese medicine composition is made medicine Acceptable preparation on.

5. Chinese medicine composition according to claim 4, it is characterised in that the preparation is tablet, capsule, granule, powder Or any one in pill.

6. the preparation method of Chinese medicine composition described in a kind of claim 4, it is characterised in that comprise the following steps：The first step, presses Weight portion weighs motherwort, leech, galangal, gadfly, corydalis tuber, frankincense, asafoetide, prepared rhizome of rehmannia, safflower, Radix Angelicae Sinensis, rhizoma cyperi, ginger Huang, rheum officinale, peach kernel, turtle shell, the root of herbaceous peony, dried lacquer, bush, Ligusticum wallichii, ginseng, myrrh, perilla seed, excrementum pteropi, cattail pollen, evodia rutaecarpa, Huang Stilbene, Radix Glycyrrhizae, Common Camptotheca Fruit, pangolin, toad, crush, and sieving is well mixed to obtain fermentation raw material；Second step, strain is added to Load fermentation tank in fermentation raw material, after stirring to be fermented；3rd step, at 33~40 DEG C, ferments 8~12 days, 20~ Low temperature is extracted at 60 DEG C, obtains moist powder；4th step, adds auxiliary material, is made pharmaceutically acceptable preparation.

7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in second step, the strain is honeybee Honey or probiotics.

8. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that the weight of the honey and fermentation raw material Amount ratio is 1~2：1, the probiotics is 0.05~0.1 with the part by weight of fermentation raw material:1.

9. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in the 3rd step, at 37 DEG C, Fermentation 10 days, low temperature is extracted at 45 DEG C, obtains moist powder.

10. application of any Chinese medicine composition of claims 1 to 3 in treatment liver-cancer medicine is prepared.