CN103251883A - Antitumor pharmaceutical composition and preparation method thereof - Google Patents
Antitumor pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN103251883A CN103251883A CN2013101599468A CN201310159946A CN103251883A CN 103251883 A CN103251883 A CN 103251883A CN 2013101599468 A CN2013101599468 A CN 2013101599468A CN 201310159946 A CN201310159946 A CN 201310159946A CN 103251883 A CN103251883 A CN 103251883A
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Abstract
The invention aims at providing a traditional Chinese medicine composition with an antitumor effect and a preparation method thereof. The traditional Chinese medicine composition is prepared from medicinal liquor and traditional Chinese medicine extract; the medicinal liquor is prepared from crystal sugar, wild walnut peel, pine needle and pure grain liquor as materials; and the traditional Chinese medicine extract is prepared from ginseng, clove, hematoxylon, peach kernel, cassia twig, musk, radix curcumae longae, gadfly, purple perilla, lucid ganoderma, dalbergia wood, myrrh, rhizoma cyperi, rhizoma corydalis, leech, ferula asafetida, folium artemisiae argyi, ligusticum wallichii, angelica sinensis, fructus evodiae, rheum officinale, turtle shell and rice vinegar as the materials. The traditional Chinese medicine extract disclosed by the invention is taken as an active substance of the medicine; a pharmaceutically acceptable carrier can be added in requirement; and the preparation is prepared according to a common technology of pharmaceutics. The invention also provides application of the traditional Chinese medicine composition in preparation of a medicine for treating a tumor. The medicines in the formula disclosed by the invention are inter-coordinated to achieve the effects of invigorating the circulation of blood line, dispersing concretion, tonifying and strengthening the body resistance, entering the liver, resolving hard lump, and attacking but not hurting, and can effectively cure the tumor.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of antineoplastic pharmaceutical compositions and preparation method thereof.
Background technology
Tumor refers to body under various tumorigenesis factor long terms, and the cellular gene expression of local organization regulation and control are unusual, thereby has lost the normal regulation of cell growth, causes the excessive reproduction of mutant and the neoplasm that forms.Malignant tumor refers to the growth of uncontrollable malignant cell and diffusion, and tissue infiltration is feature, and determines to meet " disease and cause of the death classification " standard that health ministry announces through pathological examination and belong to the disease of the row of malignant tumor.Common as: pulmonary carcinoma, leukemia, osteosarcoma, liver tumor etc. all belong to malignant tumor.
Hepatocarcinoma refers to betide the tumor of liver, comprises two kinds of primary hepatocarcinoma and secondary liver cancers, and mostly the hepatocarcinoma of the daily theory of people is primary hepatocarcinoma if referring to.Primary hepatocarcinoma is one of modal malignant tumor clinically, and according to recent statistics, the annual New Development liver cancer patient in the whole world is about 600,000, occupies the 5th of malignant tumor.Primary hepatocarcinoma can be divided into hepatocyte type hepatocarcinoma, bile duct cell type hepatocarcinoma and mixed carcinoma of liver by cell typing.
Tumor is a kind of physiological phenomenon and pathological symptom, for tumor, still there is not specific drug at present both at home and abroad, the antitumor drug majority of selling on the market is determined synthetic drug for structure, they when killing tumor cell to the epithelial cell of molecular marker for increased proliferation, all has major injury as medullary cell, digestive tract mucosal epithelium cell etc., to the body vitals, after one's own heart, lung, kidney, nervous system etc. also have certain toxicity.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition with antitumor action and preparation method thereof.
Chinese medicine composition of the present invention is made up of medicated wine and Chinese medicine extract, and described medicated wine is formed by the feedstock production of following weight portion: crystal sugar 0.1-2 kilogram, wild Cortex walnut 1-4 kilogram, state Folium Pini 2-6 kilogram, pure grain wine 8-14 kilogram; Described Chinese medicine extract is formed by the feedstock production of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10--30 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2-15 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8-16 gram, Fructus Evodiae 1-5 gram, Radix Et Rhizoma Rhei 10-40 gram, Herba Leonuri 10-40 gram, Carapax Trionycis 20-100 gram, rice vinegar 50-1000 gram.
Preferably, described medicated wine is formed by the feedstock production of following weight portion: crystal sugar 0.5-1 kilogram, wild Cortex walnut 1.5-3 kilogram, state Folium Pini 3-5 kilogram, pure grain wine 10-12 kilogram.
According to one of embodiment of the present invention, described pure grain wine is the pure grain wine that can buy on the market.
Preferably, described pure grain wine is 34-42 degree pure grain wine.
Most preferred, described pure grain wine is 38 degree pure grain wines.
Preferably, described Chinese medicine extract is formed by the feedstock production of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15--20 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5-10 gram Radix Angelicae Sinensis 10-14 gram of Rhizoma Chuanxiong, Fructus Evodiae 2-3 gram, Radix Et Rhizoma Rhei 20-30 gram, Herba Leonuri 20-30 gram, Carapax Trionycis 50-70 gram, rice vinegar 200-500 gram.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine composition after the replacement is constant.
According to Chinese medicine composition of the present invention, the preparation method of medicated wine may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 7-15 days in the glass drying oven, filter, and remove slag charge, namely.
According to Chinese medicine composition of the present invention, the preparation method of Chinese medicine extract may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 15-20 minute, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
According to the preparation method of Chinese medicine composition of the present invention, the preparation method of described medicated wine may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 7-15 days in the glass drying oven, filter, and remove slag charge, namely.
According to the preparation method of Chinese medicine composition of the present invention, the preparation method of described Chinese medicine extract may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 15-20 minute, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
The present invention is by increasing the consumption of flavour of a drug, and raw material is fully pulverized, and concocts, and means such as repeatedly boils and can effectively improve its drug effect.
The present invention also provides a kind of anti-tumor agent, as pharmaceutically active substance, adds the medicine acceptable carrier with Chinese medicine extract of the present invention when needing, the preparation of making according to the routine techniques of galenic pharmacy.
Pharmaceutically active substance in the preparation can be 0.1-100%, and all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form refers to the unit of preparation, as every of tablet, and every capsules of capsule, every bottle of oral liquid, every bag of granule etc.
Preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, drop pill, capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preferably, preparation of the present invention is peroral dosage form, as: capsule, granule, pill, powder, sublimed preparation, unguentum etc.
Most preferred, preparation of the present invention is capsule.
The application of Chinese medicine composition of the present invention in the medicine of preparation treatment tumor.
The application of Chinese medicine composition of the present invention in the medicine of preparation treatment liver tumor.
Described liver tumor refers to constitutional liver tumor and metastatic hepatic neoplasm.
Chinese medicine composition of the present invention is used by the preparation of medicated wine and Chinese medicine extract, regulates the usage ratio of Chinese medicine extract and medicated wine according to conditions of patients.Medicated wine and Chinese medicine extract also can use separately.
Adopt Chinese medicine composition of the present invention, be used by the preparation of medicated wine and Chinese medicine extract or Chinese medicine extract, prescription medicine coordinates to reach the promoting the circulation of blood of invigorating blood circulation mutually, disease eliminating powder junction, tonification is set upright, and is pure and go into liver, hard masses softening and resolving is attacked and is not just hindered, and can effectively cure tumor.
Clinical trial proves: liver tumor patient takes the Chinese medicine composition state of an illness of the present invention all to be had in various degree and alleviates, the tumor body obviously dwindled in 20-30 days, substantially cured to half a year in 3 months, and in addition transfevent liver tumor and lung, stomach, hysteromyoma etc. were also had the effect that suppresses and dwindle.
The specific embodiment
Describe embodiments of the invention below in detail, described embodiment is exemplary, only is used for explaining the present invention, and can not be interpreted as limitation of the present invention.
Embodiment 1
Medicinal liquor prescription: 0.1 kilogram in crystal sugar, 1 kilogram of wild Cortex walnut, 2 kilograms of state's Folium Pinis, 8 kilograms of 34 degree pure grain wines;
The medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 process of preparing Chinese medicine: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 7 days in the glass drying oven into, filter, and remove slag charge, namely.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8 grams, Fructus Evodiae 1 gram, Radix Et Rhizoma Rhei 10 grams, Herba Leonuri 10 grams, Carapax Trionycis 20 grams, rice vinegar 50 grams;
The Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 15 minutes, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
Embodiment 2
Medicinal liquor prescription: 2 kilograms in crystal sugar, 4 kilograms of wild Cortex walnuts, 6 kilograms of state's Folium Pinis, 14 kilograms of 42 degree pure grain wines;
The medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 10 days in the glass drying oven, filter, and remove slag charge, namely.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 30 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 15 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 16 grams, Fructus Evodiae 5 grams, Radix Et Rhizoma Rhei 40 grams, Herba Leonuri 40 grams, Carapax Trionycis 100 grams, rice vinegar 1000 grams;
The Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 20 minutes, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
Embodiment 3
Medicinal liquor prescription: 0.5 kilogram in crystal sugar, 1.5 kilograms of wild Cortex walnuts, 3 kilograms of state's Folium Pinis, 11 kilograms of 38 degree pure grain wines;
The medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 15 days in the glass drying oven, filter, and remove slag charge, namely.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 12 grams, Fructus Evodiae 2 grams, Radix Et Rhizoma Rhei 20 grams, Herba Leonuri 20 grams, Carapax Trionycis 50 grams, rice vinegar 200 grams;
The Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 4mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 18 minutes, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
Embodiment 4
Medicinal liquor prescription: 1 kilogram in crystal sugar, 3 kilograms of wild Cortex walnuts, 5 kilograms of state's Folium Pinis, 12 kilograms of 38 degree pure grain wines;
The medicated wine preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 12 days in the glass drying oven, filter, and remove slag charge, namely.
Chinese medicine extraction composition formula: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 20 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 10 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 15 grams, Fructus Evodiae 5 grams, Radix Et Rhizoma Rhei 30 grams, Herba Leonuri 30 grams, Carapax Trionycis 70 grams, rice vinegar 300 grams;
The Chinese medicine extract preparation method:
Step 1 is cleaned: get above-mentioned raw material in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 20 minutes, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
Embodiment 5
Get embodiment 1 gained Chinese medicine extract 25%, xylitol 48%, maltose 6%, 14% cyclodextrin, 7% calcium lactate prepare soft capsule according to the soft capsule common process and namely get soft capsule.
Embodiment 6
Get embodiment 3 gained Chinese medicine extract, under room temperature is aseptic, incapsulate, namely get capsule.
Embodiment 7
The Chinese medicine extract 75g microcrystalline Cellulose 37g micropowder silica gel 2.3g magnesium stearate 1.1g that [prescription] embodiment 4 obtains
[method for making] got former, adjuvant and crossed 100 mesh sieves respectively; Get extractum, microcrystalline Cellulose, mixing in right amount as binding agent soft material processed, is crossed 20 mesh sieves granule processed with 60% ethanol, and 60 ℃ of dryings are taken out, and cross 30 mesh sieve granulate, add an amount of micropowder silica gel and magnesium stearate, mixing, and tabletting is made 1000, namely.
The test example
Case 1: turn round and look at certain, woman, 39 years old.2009 in first hospital ultrasonic examination finding, the huge solid tumor mass 13.0*13.9*16.0cm of leftlobe of liver size, and form is irregular, and obscure boundary is the tuberosity sense, and inner echo is mixed and disorderly based on the low echo of substance, mixed and disorderly strong echo between substantive low echo nodules.The maximum clino-diagonal 10.8cm of right lobe of liver.The visible 1.4*2.1*2.2cm of right lobe of liver, strong echo kitchen range such as 1.6*1.7,1.8*1.9cm, form is irregular, and CT examination is the liver multiple tumor, is diagnosed as hepatocarcinoma.Make a definite diagnosis back beginning in the 9th day medication, six hours are once, each 6 capsules (preparation method is seen embodiment 6, the heavy 0.39-0.4g of every capsules), medicated wine every day sooner or later each once, each 25-30g.The right side of body of medication patient's private prosecution in 6 days distending pain alleviates, 15 days no senses of discomfort, and check leftlobe of liver tumor body was 10.3*9.7*12.0cm in one month 0 two days, right lobe of liver 1.0*1.6*2.1cm, 1.4*1.3cm, 1.7*1.4cm.3 months leftlobe of liver of medication are 3.9*4.2*6.1cm, and right lobe of liver can't see the tumor body.Medication basic rehabilitation half a year.Check returns to one's perfect health after 8 months.
Case 2: Chen, man, 46 years old.March 17 calendar year 2001 is unenhanced at the upper abdomen CT of second hospital.Upper left abdomen shows: 10*12cm agglomerate shadow, and density unevenness in it, the upper bound and right lobe of liver boundary are unclear, show a plurality of brief summary nodular low-density kitchen ranges in the right lobe of liver, and the peritoneum structure shows brief summary nodular enlarged lymph node.CT diagnosis: upper left abdomen occupy-place.Consider lobus sinister liver ca and lobus dexter liver m.Be diagnosed as hepatocarcinoma March 23 calendar year 2001 at certain provincial hospital.Do chemotherapy and can't stand vomiting 2 times, the patient leaves hospital voluntarily.Begin to take medicine April 5 the same year, and per six hours clothes once each 6, are respectively drunk medicated wine half two sooner or later.Medication check in 3 months 06 days tumor body is little of 7.2*9.6cm.Peritoneum does not show.
Case 3: rope, man, 63 years old.2010 rectal cancer surgeries of doing in certain the People's Hospital, city, on March 17th, 2012 checked in this hospital: chest CT scans.Two lung marking are more, visible a plurality of brief summary nodular high density shadows in two lung fields.With the relatively slightly increase of tuberosity of preceding CT sheet, visible enlarged lymph node shadow in the vertical diaphragm.CT diagnosis: lung M, vertical diaphragm lymph enlargement.Capsule (preparation method is seen embodiment 6) is taken on March 21st, 2012 beginning, medication in per 6 hours once, each 6.Check on June 9th, 2012.Above-mentioned hospital CT examination report: chest CT scans.Rectum Ca lung M check: thorax is symmetry substantially, and two lung marking are clear, and inferior lobe of right lung shows two nodositas high density kitchen ranges, density unevenness, edge are shallow lobulated, show no obvious abnormalities in the surplus lung field, focus than on March 17th, 2012 the CT sheet do not see significant change, do not see obvious enlarged lymph node in the vertical diaphragm.On March 25th, 2013 checked again, and CT checks finding: lung M check: two lungs are clear, and right lung is marched off into political wilderness and shown two soft tissue tuberosity kitchen ranges, and density is light, and the border is still clear, do not see enlarged lymph node in the vertical diaphragm.It is fine to appear the body situation.Continue to take medicine.
Case 4: Zhao, woman, 41 years old.On April 18th, 2011 had a medical check-up and checks out multiple myomata, and maximum 3.8*4.3cm begins to take medicine every day 4 times each 6 capsules on May 20th, 2011.JIUYUE in 2011 check on the 11st tumor body obviously is decreased to 1.4*1.8.
Claims (10)
1. Chinese medicine composition, it is characterized in that, described Chinese medicine composition is made up of medicated wine and Chinese medicine extract, and its Chinese medicinal liquor is formed by the feedstock production of following weight portion: crystal sugar 0.1-2 kilogram, wild Cortex walnut 1-4 kilogram, state Folium Pini 2-6 kilogram, pure grain wine 8-14 kilogram; Chinese medicine extract is formed by the feedstock production of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 10--30 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 2-15 gram of Rhizoma Chuanxiong, Radix Angelicae Sinensis 8-16 gram, Fructus Evodiae 1-5 gram, Radix Et Rhizoma Rhei 10-40 gram, Herba Leonuri 10-40 gram, Carapax Trionycis 20-100 gram, rice vinegar 50-1000 gram.
2. Chinese medicine composition according to claim 1 is characterized in that described medicated wine is formed by the feedstock production of following weight portion: crystal sugar 0.5-1 kilogram, wild Cortex walnut 1.5-3 kilogram, state Folium Pini 3-5 kilogram, pure grain wine 10-12 kilogram.
3. as Chinese medicine composition as described in the claim 2, it is characterized in that described pure grain wine is 34-42 degree pure grain wine.
4. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine extract is formed by the feedstock production of following weight portion: Radix Ginseng, Flos Caryophylli, Lignum Sappan, each 15--20 gram of Semen Persicae, Ramulus Cinnamomi, Moschus, Rhizoma Curcumae Longae, Tabanus, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Myrrha, Rhizoma Cyperi, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, each 5-10 gram Radix Angelicae Sinensis 10-14 gram of Rhizoma Chuanxiong, Fructus Evodiae 2-3 gram, Radix Et Rhizoma Rhei 20-30 gram, Herba Leonuri 20-30 gram, Carapax Trionycis 50-70 gram, rice vinegar 200-500 gram.
5. Chinese medicine composition according to claim 1 is characterized in that the preparation method of described medicated wine may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 7-15 days in the glass drying oven, filter, and remove slag charge, namely.
6. Chinese medicine composition according to claim 1 is characterized in that the preparation method of described Chinese medicine extract may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 15-20 minute, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
7. the preparation method of Chinese medicine composition according to claim 1 is characterized in that the preparation method of described medicated wine may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is concocted: with crystal sugar, wild Cortex walnut, state's Folium Pini are packed into jointly and are poured pure grain wine sealing 7-15 days in the glass drying oven, filter, and remove slag charge, namely;
The preparation method of described Chinese medicine extract may further comprise the steps:
Step 1 is cleaned: get various raw materials in proportion and clean, dry standby;
Step 2 is pulverized: Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Lignum Sappan, Radix Angelicae Sinensis, Ganoderma, Lignum Dalbergiae Odoriferae, Rhizoma Chuanxiong, Radix Et Rhizoma Rhei, Herba Leonuri, turtle ' s carapace powder are broken into the long fritter of 3-5mm, again Herba Leonuri, Radix Et Rhizoma Rhei, Carapax Trionycis are ground into fine powder, sieve, get motherwort powder, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder, standby, Moschus list equipment usefulness, Semen Persicae removes point;
Step 3 is mixed and is decocted: after Radix Ginseng, Ramulus Cinnamomi, Rhizoma Curcumae Longae, Flos Caryophylli, Tabanus, Lignum Sappan, Semen Persicae, Folium Perillae, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Angelicae Sinensis, Myrrha, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Corydalis, Hirudo, Resina Ferulae, Folium Artemisiae Argyi, Rhizoma Chuanxiong are put into that vessel are even and mixed, putting the interior rice vinegar that adds of digester heats to boiling, boil and changed slow fire receipts juice in 15-20 minute, juice receive to be done the back cooling cold of drying in the air of ceasing fire and is dried, put in the digester again after drying, add rice vinegar, dense enduring received the juice cooling cold of drying in the air and dried, three times repeatedly, get extract after drying, standby;
Step 4 levigation mixes with secondary: the described extract of step 3 is ground into fine powder sieves, then with the described motherwort powder of step 2, Radix Et Rhizoma Rhei powder, turtle ' s carapace powder and Moschus mix homogeneously, namely.
8. an anti-tumor agent is characterized in that, as pharmaceutically active substance, adds the medicine acceptable carrier with each described Chinese medicine extract of claim 1-6 when needing, the preparation of making according to the routine techniques of galenic pharmacy.
9. as anti-tumor agent as described in the claim 8, it is characterized in that the dosage form of described preparation comprises: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, drop pill, capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, injection, suppository, ointment, plaster, cream, spray, drop, patch.
10. the application of the described Chinese medicine composition of claim 1 in the medicine of preparation treatment tumor.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106692871A (en) * | 2016-09-21 | 2017-05-24 | 深圳市得道中医馆管理有限责任公司 | Traditional Chinese medicine composition, preparation method thereof and application of traditional Chinese medicine composition in liver cancer treatment |
| CN115700276A (en) * | 2022-11-25 | 2023-02-07 | 广西农科环保科技有限公司 | Formula and preparation method of black soldier fly and ginseng nutritional wine |
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| WO2017173611A1 (en) * | 2016-04-07 | 2017-10-12 | 北京路德凯奇商贸有限责任公司 | Pharmaceutical product for treating tumor and combined immune defect, and preparation and application thereof |
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