CN107661392A - A kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof.The Chinese medicine compound prescription is made up of following raw material：25 ~ 35 parts of dindygulen peperomia herb, 20 ~ 25 parts of Rabdosia rubescens, 15 ~ 20 parts of oldenlandia diffusa, 10 ~ 15 parts of inular flower, 10 ~ 15 parts of myrrh, 15 ~ 25 parts of subprostrate sophora, 8 ~ 15 parts of radix glycyrrhizae, 15 ~ 25 parts of ginseng, 8 ~ 13 parts of frankincense, 25 ~ 35 parts of Sculellaria barbata.The Chinese medicine compound prescription of the present invention can effectively control the transfer of primary lesion and metastatic lesion to continue to spread, it is relieved the clinical symptoms of cancer of the esophagus, have no toxic side effect, can significantly mitigate the pain of patient, it is curative for effect, take effect it is quick, safe to use, quality controllable, convenient to take.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof.
Background technology
Cancer of the esophagus is one of clinical relatively conventional malignant tumour, and a kind of more refractory disease, serious threat
People's health.Cancer of the esophagus onset is hidden, in early days can be asymptomatic.Some patientss have foreign body in esophagus sense, or pass through from food
When slowly or have a choking feeling.Burnt when can also appear as swallowing after breastbone, acupuncture sample or drawing sample pain.Therapy for advanced esophageal cancer is then normal
Because of dyscatabrosis, the period state of an illness is more serious, loses operative treatment chance, and chemicotherapy turns into the Main Means for the treatment of.In
Advanced esophageal cancer patient during treatment or treatment after cancer cell transfer and cause conditions of patients recurrent exerbation, and late period eat
Often there is the stronger drug resistance to some chemotherapeutics over the course for the treatment of in road cancer, therefore influences the therapeutic effect of patient.And
Chemicotherapy greatly and can bring the intolerable pain of ordinary person to human injury, while cancer cell is killed, will also result in
The damage of normal cell, cause a variety of serious complication.And traditional Chinese medicine has many advantages in terms of cancer of the esophagus is treated.Food
Road cancer thinks in traditional Chinese medicine category " choke every " category, traditional Chinese medicine, this sick generation more by be worried it is angry, drink it is thermophilic it is pungent, internal lesion caused by overexertion is excessive,
Cause liver depression, insufficiency of the spleen, kidney wound, formed caused by a series of pathological changes such as the solidifying obstruction of the circulation of vital energy, blood addiction, phlegm, hyperactivity of fire, Tianjin be withered, its lesion
Position, although mainly in esophagus and stomach, there is substantial connection every the dirty functional disturbance such as liver depression kidney can be made with liver, spleen, choke.Traditional Chinese medicine
Because it is tired, clearing heat and detoxicating with promoting blood circulationization, strengthen the body resistance to consolidate the constitution and other effects play antitumor action, may act on tumorigenesis
Multiple links.Chinese medicine is suppressing killing tumor cell, improves symptom and is mitigating chemicotherapy adverse reaction, extending survival of patients
Phase etc. plays a significant role.But effective Chinese medicine compound prescription for the treatment of cancer of the esophagus is also very rare at present.
At present Western medicine chemicotherapy therapeutic modality is mainly used for treatment cancer of the esophagus.Its therapeutic effect it is not only undesirable but also
Many damages are also caused to patient itself, thus cause body and all many-sides of psychology to cause serious shadow to patient
Ring.Rarity of the Chinese medicine as China, show, with the treatment cancer of the esophagus effect of Mutiple Targets multi-angle, to reach and subtract through modern study
Somatic damage caused by few chemicotherapy, but its treatment cycle is longer and taste is bad so that many patients can not accept.
The content of the invention
Present invention aims to overcome that the defects of problem above, there is provided a kind of to be used to treat in early, middle and late phase cancer of the esophagus
Medicine compound and preparation method thereof.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of Chinese medicine compound prescription for treating cancer of the esophagus, it is made up of following raw material：25 ~ 35 parts of dindygulen peperomia herb, Rabdosia rubescens 20 ~ 25
Part, 15 ~ 20 parts of oldenlandia diffusa, 10 ~ 15 parts of inular flower, 10 ~ 15 parts of myrrh, 15 ~ 25 parts of subprostrate sophora, 8 ~ 15 parts of radix glycyrrhizae, ginseng
15 ~ 25 parts, 8 ~ 13 parts of frankincense, 25 ~ 35 parts of Sculellaria barbata.
The preparation method of the Chinese medicine compound prescription of above-mentioned treatment cancer of the esophagus, comprises the following steps：
(1) dindygulen peperomia herb, Rabdosia rubescens, oldenlandia diffusa, inular flower, myrrh, subprostrate sophora, radix glycyrrhizae, ginseng, breast are taken by bulk drug proportioning
Fragrant, Sculellaria barbata, crush and mix, Extraction solvent is used as by the use of 70% ethanol, 70 ~ 80 DEG C of heating and refluxing extractions 3 times, it is small to extract 2 every time
When, each post processing extraction solvent consumption is 10 ~ 15 times of bulk drug gross weight, filtering, obtains dregs of a decoction A and extract solution A, concentrated extracting solution A is obtained
Extractum A, then extractum A is first eluted with water, then eluted with 70% ethanol solution, collection second by FU-01 large pore resin absorption columns
Alcohol eluen, it is concentrated and dried, produces extract A；
(2) step (1) Chinese medicine slag A is taken by the use of 50% ethanol as Extraction solvent, heating and refluxing extraction 6 times, extraction 45 minutes every time,
Each solvent load is 8 ~ 10 times of dregs of a decoction A weight, filtering, obtains dregs of a decoction B and extract solution B, and concentrated extracting solution B obtains medicinal extract B, then will leaching
Cream B is first eluted with water, then eluted with 90% ethanol solution, collection ethanol eluate, concentration by FU-06 large pore resin absorption columns
Dry, produce extract B；
(3) extract A and extract B are mixed, produced.
In above-mentioned preparation method, the amount that large pore resin absorption column is eluted with water in step (1) and step (2) is every gram of medicinal extract
0.5 ~ 1L water is needed, is that every gram of medicinal extract needs 1 ~ 2L ethanol with amount of alcohol.
A kind of pharmaceutical preparation containing above-mentioned Chinese medicine compound prescription, piece is made by the Chinese medicine compound prescription and pharmaceutically acceptable auxiliary material
Agent, capsule or dripping pill；Pharmaceutically acceptable auxiliary material is drug field auxiliary material conventional and general in above-mentioned formulation is prepared,
And it is made according to this area customary preparation methods.
Above-mentioned Chinese medicine compound prescription is applied in the medicine for the treatment of cancer of the esophagus.
The drug effect of raw material used in the present invention：
Subprostrate sophora：It is bitter, cold in nature, it is poisonous.Attach to the lung and stomach meridians.The effect of with clearing heat and detoxicating, clearing heat and detoxicating, reducing pharyngeal swelling, commonly use
In abscess of throat, swelling and aching of gum.
Oldenlandia diffusa：It is mildly bitter flavor, sweet, cold in nature.Return stomach, large intestine, small intestinl channel.With the work(that clearing heat and detoxicating, dampness removing are treating stranguria
Effect, is usually used in carbuncle sore tumefacting virus, abscess of throat, venomous snake bite, puckery pain of heat gonorrhea.
Radix glycyrrhizae：It is sweet.It is mild-natured.The thoughts of returning home, lung, spleen, stomach.It is all with clearing heat and detoxicating, cough-relieving apophlegmatic, tonifying spleen and stomach, mediation
The effect of medicine.
Sculellaria barbata:Acrid flavour.It is mild-natured.It is promoting blood circulation and removing blood stasis with clearing heat and detoxicating, the effect of swelling and pain relieving.
Frankincense：It is acrid flavour, hardship, warm-natured.The thoughts of returning home, liver, the spleen channel.The effect of with blood-activating and qi-promoting analgesic, detumescence and promoting granulation, it is usually used in
Qi depression to blood stasis pain is demonstrate,proved, sore carbuncle swells, traumatic injury.
Myrrh：It is acrid flavour, hardship, warm-natured.The thoughts of returning home, liver, the spleen channel.The effect of with blood-activating and qi-promoting analgesic, detumescence and promoting granulation, it is usually used in
Qi depression to blood stasis pain is demonstrate,proved, sore carbuncle swells, traumatic injury.
Inular flower：Bitter, pungent, salty, slightly warm in nature.Attach to the lung and stomach meridians.The effect of with lowering the adverse-rising QI to resolve phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, it is usually used in
Cough and phlegm, phlegm and retained fluid store knot, chest diaphragm feeling of fullness, gas vomiting.
Ginseng：Sweet, slight bitter, slightly warm in nature.Return lung, spleen, the heart channel of Hang-Shaoyin.With reinforcing vital energy, tonifying spleen benefit stomach, promote the production of body fluid, benefit of calming the nerves
The effect of intelligence, it is usually used in vigour collapse card, lung spleen heart syndrome of deficiency of kidney qi, pyreticosis deficiency of vital energy Tianjin wound, thirsty and diabete.
Rabdosia rubescens：Bitter, sweet, cold nature.Return lung warp, stomach, Liver Channel.With clearing heat and detoxicating, the effect of promoting blood circulation and stopping pain, often
For controlling abscess of throat, addiction lump in the abdomen lump in the abdomen, snake bite and insect sting.
Dindygulen peperomia herb：It is cool in nature, lightly seasoned, slight bitter.Return lung warp, the spleen channel, Liver Channel, kidney channel.With clearing heat and detoxicating, scattered stasis detumescence, only
Bitterly sharp water the effect of.
Compared with prior art, the invention has the advantages that：The Chinese medicine compound prescription of the present invention can effectively control original
Fall ill the transfer of stove and metastatic lesion continues to spread, hence it is evident that alleviate the clinical symptoms of cancer of the esophagus, have no toxic side effect, can be notable
Mitigate patient pain, it is curative for effect, take effect it is quick, safe to use, quality controllable, convenient to take.Chinese medicine compound prescription of the present invention carries
The bad smell of medicine institute's band in itself can be covered by taking mixture to be fabricated to capsule, pill etc., be easy to swallow, can be with
Medicine stability and bioavilability are improved, is advantageous to the absorption of its active ingredient.The preparation method of the Chinese medicine compound prescription of the present invention
Simply, wide market, it is adapted to large-scale production.
Embodiment
The present invention is described in further detail with reference to instantiation：
Embodiment 1
A kind of Chinese medicine compound prescription for treating cancer of the esophagus, is made up of following raw material：Dindygulen peperomia herb 25g, the g of Rabdosia rubescens 20, oldenlandia diffusa 15
G, the g of inular flower 10, the g of myrrh 10, the g of subprostrate sophora 15, the g of radix glycyrrhizae 8, the g of ginseng 15, the g of frankincense 8, the g of Sculellaria barbata 25.
The preparation method of above-mentioned Herbal compound capsule agent, comprises the following steps：
(1) dindygulen peperomia herb, Rabdosia rubescens, oldenlandia diffusa, inular flower, myrrh, subprostrate sophora, radix glycyrrhizae, ginseng, breast are taken by bulk drug proportioning
Fragrant, Sculellaria barbata, crush and mix, be used as Extraction solvent, 70 ~ 80 DEG C of heating and refluxing extractions by the use of 70% ethanol, extraction time is 3 times, often
Secondary extraction time is 2 hours, and each solvent load is times of bulk drug gross weight 10 ~ 15, filtration, obtains dregs of a decoction A and extract solution A,
Concentrated extracting solution A simultaneously reclaims ethanol, is concentrated to give it after medicinal extract by FU-01 large pore resin absorption columns, is first eluted with water, uses water
Measure needs 0.5 ~ 1L water for every gram of medicinal extract, then elutes FU-01 large pore resin absorption columns with 70% ethanol solution, is every gram with amount of alcohol
Medicinal extract needs 1 ~ 2L ethanol, collects ethanol eluate, reclaims ethanol, is concentrated and dried, produces extract A；
(2) step (1) dregs of a decoction are taken, by the use of 50% ethanol as Extraction solvent, 70 ~ 80 DEG C of heating and refluxing extractions, extraction time is 6 times,
Each extraction time is 45 minutes, and each solvent load is times of dregs of a decoction weight 8 ~ 10, filtration, obtains dregs of a decoction B and extract solution B, dense
Contracting extract solution B simultaneously reclaims ethanol, is concentrated to give medicinal extract, after by it by FU-06 large pore resin absorption columns, be first eluted with water, use water
Measure needs 0.5-1L water for every gram of medicinal extract, then elutes FU-06 large pore resin absorption columns with 90% ethanol solution, is every gram with amount of alcohol
Medicinal extract needs 1-2L ethanol, collects ethanol eluate, reclaims ethanol, is concentrated and dried, produces extract B；
(3) extract A and extract B are mixed, is fitted into capsule shells and the capsule grain of 0.25g/ grains is made.
Instructions of taking：Orally, 3 times a day, 2 tablets each time.
Embodiment 2
A kind of Chinese medicine compound prescription for treating cancer of the esophagus, is made up of following raw material：The g of dindygulen peperomia herb 30, the g of Rabdosia rubescens 25, oldenlandia diffusa
20 g, the g of inular flower 15, the g of myrrh 15, the g of subprostrate sophora 20, the g of radix glycyrrhizae 12, the g of ginseng 20, the g of frankincense 10, the g of Sculellaria barbata 30.
The preparation method of above-mentioned Chinese medicine compound prescription tablet, comprises the following steps：
(1) dindygulen peperomia herb, Rabdosia rubescens, oldenlandia diffusa, inular flower, myrrh, subprostrate sophora, radix glycyrrhizae, ginseng, breast are taken by bulk drug proportioning
Fragrant, Sculellaria barbata, crush and mix, be used as Extraction solvent, 70 ~ 80 DEG C of heating and refluxing extractions by the use of 70% ethanol, extraction time is 3 times, often
Secondary extraction time is 2 hours, and each solvent load is times of bulk drug gross weight 10 ~ 15, filtration, obtains dregs of a decoction A and extract solution A,
Concentrated extracting solution A simultaneously reclaims ethanol, is concentrated to give it after medicinal extract by FU-01 large pore resin absorption columns, is first eluted with water, uses water
Measure needs 0.5 ~ 1L water for every gram of medicinal extract, then elutes FU-01 large pore resin absorption columns with 70% ethanol solution, is every gram with amount of alcohol
Medicinal extract needs 1 ~ 2L ethanol, collects ethanol eluate, reclaims ethanol, is concentrated and dried, produces extract A；
(2) step (1) dregs of a decoction are taken, is 6 times by the use of 50% ethanol as Extraction solvent, heating and refluxing extraction, extraction time, carries every time
It is 45 minutes to take the time, and each solvent load is times of dregs of a decoction weight 8 ~ 10, filtration, obtains dregs of a decoction B and extract solution B, concentration extraction
Liquid B simultaneously reclaims ethanol, is concentrated to give medicinal extract, after by it by FU-06 large pore resin absorption columns, be first eluted with water, water consumption is every
Gram medicinal extract needs 0.5-1L water, then elutes FU-06 large pore resin absorption columns with 90% ethanol solution, is that every gram of medicinal extract needs with amount of alcohol
1-2L ethanol, ethanol eluate is collected, reclaim ethanol, be concentrated and dried, produce extract B；
(3) extract A and extract B are mixed, tablet, every 0.25g is made in tabletting.
Instructions of taking：Orally, 3 times a day, 2 tablets once.
Embodiment 3
A kind of Chinese medicine compound prescription for treating cancer of the esophagus, is made up of following raw material：Dindygulen peperomia herb 35g, the g of Rabdosia rubescens 30, oldenlandia diffusa
25g, the g of inular flower 20, the g of myrrh 20, the g of subprostrate sophora 25, the g of radix glycyrrhizae 15, the g of ginseng 25, the g of frankincense 12, the g of Sculellaria barbata 35.
The preparation method of above-mentioned compound traditional Chinese medicinal dripping pills agent, comprises the following steps：
(1) dindygulen peperomia herb, Rabdosia rubescens, oldenlandia diffusa, inular flower, myrrh, subprostrate sophora, radix glycyrrhizae, ginseng, breast are taken by bulk drug proportioning
Fragrant, Sculellaria barbata, crush and mix, be used as Extraction solvent, 70 ~ 80 DEG C of heating and refluxing extractions by the use of 70% ethanol, extraction time is 3 times, often
Secondary extraction time is 2 hours, and each solvent load is times of bulk drug gross weight 10 ~ 15, filtration, obtains dregs of a decoction A and extract solution A,
Concentrated extracting solution A simultaneously reclaims ethanol, is concentrated to give it after medicinal extract by FU-01 large pore resin absorption columns, is first eluted with water, uses water
Measure needs 0.5 ~ 1L water for every gram of medicinal extract, then elutes FU-01 large pore resin absorption columns with 70% ethanol solution, is every gram with amount of alcohol
Medicinal extract needs 1 ~ 2L ethanol, collects ethanol eluate, reclaims ethanol, is concentrated and dried, produces extract A；
(2) step (1) dregs of a decoction are taken, is 6 times by the use of 50% ethanol as Extraction solvent, heating and refluxing extraction, extraction time, carries every time
It is 45 minutes to take the time, and each solvent load is times of dregs of a decoction weight 8 ~ 10, filtration, obtains dregs of a decoction B and extract solution B, concentration extraction
Liquid B simultaneously reclaims ethanol, is concentrated to give medicinal extract, after by it by FU-06 large pore resin absorption columns, be first eluted with water, water consumption is every
Gram medicinal extract needs 0.5-1L water, then elutes FU-06 large pore resin absorption columns with 90% ethanol solution, is that every gram of medicinal extract needs with amount of alcohol
1-2L ethanol, ethanol eluate is collected, reclaim ethanol, be concentrated and dried, produce extract B；
(3) extract A and extract B are mixed into obtain Chinese medicinal compound extract；
(4) Macrogol 4000, Macrogol 6000 or poloxamer matrix are added under conditions of stirring in container is heated
Heat is then 1 according to the weight of Chinese medicinal compound extract and matrix ratio until melting:12 toward melting matrix in add extract,
Pill dripping machine fluid reservoir is heated to 75 ~ 85 DEG C of temperature afterwards, Chinese medicinal compound extract and auxiliary material etc. are entered into fluid reservoir, passed through
Water dropper drips to compound traditional Chinese medicinal dripping pills material in the condensate liquid that temperature is 4 ~ 6 DEG C, and the dripping pill for collecting shaping is exported in pill dripping machine, is wiped
Surface coolant is gone, is dried, described compound traditional Chinese medicinal dripping pills is obtained, is fitted into bag and seals, 0.5g/ bags.
Instructions of taking：It is buccal, 3 times a day, each taking one bag（0.5 gram）.
Animal toxicity test：
Taking experiment mice 120, male and female half and half, 140 ~ 180g of body weight is respectively divided into three group 1 ~ 3, every group each 40, and every group
Bearing Mice Life sign is good, and the physiological performance such as body weight is without exception, has comparativity.
1. the Chinese medicinal compound extract of the treatment cancer of the esophagus prepared respectively using the embodiment of the present invention 1 ~ 3 to three groups of mouse is molten
Thing is solved, gastric infusion three times a day, is continuously taken one month, observed during experiment and record the sign situation of all mouse.
2. the sign presentation of all mouse is without exception in experimentation, do not occur death condition after off-test, to every group
Five are randomly selected in mouse and carries out dissection inspection, major organs are no abnormal, from experimental result, in the present invention
Chinese medicinal compound extract, can safety clothes use without overt toxicity.
Clinical statisticses data：
1. case is chosen：Clinically choose the esophageal cancer patients 180 made a definite diagnosis, wherein male 96, women 84, age
13 ~ 67 years old, average age 43 years old.
2. experimental method：The compound extract prepared respectively using the embodiment of the present invention 1 ~ 3 to experimental group 1 ~ 3, daily three
It is secondary, continuously take 3 months, observe and record the recovery situation of patient.
3. curative effect judging standard：
Complete incidence graph：Tumor disappearance simultaneously continues more than one month；
Alleviate part：The maximum diameter product that is mutually perpendicular to of two, tumour reduces more than 50% and continues one month；
It is stable：The maximum diameter product that is mutually perpendicular to of two, tumour is reduced less than 50%, and increase is no more than more than 25% and continues one
Individual month；
Deteriorate：The maximum diameter product that is mutually perpendicular to of two, tumour increases above more than 25% and continues one month.
4. experimental data counts：
Main adverse reaction is digestive tract reaction, and Nausea and vomiting symptom occur in three groups of experimental groups, and three groups are showed no and blood occur
Learn adverse reaction.
5. experimental result：As can be seen from the above experimental data, the treatment cancer of the esophagus Chinese medicine compound prescription for preparing of the present invention for
The total effective rate of cancer of the esophagus is 93.9%, can improve immunity of organisms, significantly inhibits function of tumor, therefore illustrate the present invention's
Chinese medicine compound prescription is to treat the safe and effective medicine of cancer of the esophagus, has good clinical expansion meaning.
Claims (5)
1. a kind of Chinese medicine compound prescription for treating cancer of the esophagus, it is characterised in that it is made up of following raw material：Dindygulen peperomia herb 25 ~ 35
It is part, 20 ~ 25 parts of Rabdosia rubescens, 15 ~ 20 parts of oldenlandia diffusa, 10 ~ 15 parts of inular flower, 10 ~ 15 parts of myrrh, 15 ~ 25 parts of subprostrate sophora, sweet
8 ~ 15 parts of grass, 15 ~ 25 parts of ginseng, 8 ~ 13 parts of frankincense, 25 ~ 35 parts of Sculellaria barbata.
2. the preparation method of the Chinese medicine compound prescription for the treatment of cancer of the esophagus as claimed in claim 1, it is characterised in that including following step
Suddenly：
(1) dindygulen peperomia herb, Rabdosia rubescens, oldenlandia diffusa, inular flower, myrrh, subprostrate sophora, radix glycyrrhizae, ginseng, breast are taken by bulk drug proportioning
Fragrant, Sculellaria barbata, which crushes, to be mixed, and Extraction solvent is used as by the use of 70% ethanol, 70 ~ 80 DEG C of heating and refluxing extractions 3 times, is extracted 2 hours every time,
Each post processing extraction solvent consumption is 10 ~ 15 times of bulk drug gross weight, filtering, obtains dregs of a decoction A and extract solution A, concentrated extracting solution A obtains medicinal extract
A, then extractum A is first eluted with water, then washed with the elution of 70% ethanol solution, collection ethanol by FU-01 large pore resin absorption columns
De- liquid, is concentrated and dried, produces extract A；
(2) step (1) Chinese medicine slag A is taken by the use of 50% ethanol as Extraction solvent, heating and refluxing extraction 6 times, extraction 45 minutes every time,
Each solvent load is 8 ~ 10 times of dregs of a decoction A weight, filtering, obtains dregs of a decoction B and extract solution B, and concentrated extracting solution B obtains medicinal extract B, then will leaching
Cream B is first eluted with water, then eluted with 90% ethanol solution, collection ethanol eluate, concentration by FU-06 large pore resin absorption columns
Dry, produce extract B；
(3) extract A and extract B are mixed, produced.
3. preparation method as claimed in claim 2, it is characterised in that：Macroporous absorption is eluted with water in step (1) and step (2)
The amount of resin column is that every gram of medicinal extract needs 0.5 ~ 1L water, is that every gram of medicinal extract needs 1 ~ 2L ethanol with amount of alcohol.
A kind of 4. pharmaceutical preparation of the Chinese medicine compound prescription containing described in claim 1, it is characterised in that the Chinese medicine compound prescription and pharmaceutically
Tablet, capsule or dripping pill is made in acceptable auxiliary material.
5. application of the Chinese medicine compound prescription described in claim 1 in esophageal cancer medicine is treated.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815349A (en) * | 2018-08-31 | 2018-11-16 | 刘正奇 | A kind of anticancer, antitumor Chinese medicine preparation and preparation method thereof |
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| CN1203085A (en) * | 1997-06-19 | 1998-12-30 | 孙文富 | Pure Chinese medicine anticancer preparation |
| CN106038765A (en) * | 2016-08-12 | 2016-10-26 | 郑州大学 | Application of compound Rabdosia rubescens preparation to chemical prevention of esophagus cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203085A (en) * | 1997-06-19 | 1998-12-30 | 孙文富 | Pure Chinese medicine anticancer preparation |
| CN106038765A (en) * | 2016-08-12 | 2016-10-26 | 郑州大学 | Application of compound Rabdosia rubescens preparation to chemical prevention of esophagus cancer |
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| Title |
|---|
| SOPHIE CHEN: "The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.", 《INTERNATIONAL JOURNAL OF ONCOLOGY》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108815349A (en) * | 2018-08-31 | 2018-11-16 | 刘正奇 | A kind of anticancer, antitumor Chinese medicine preparation and preparation method thereof |
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Application publication date: 20180206 |