CN108815349A - A kind of anticancer, antitumor Chinese medicine preparation and preparation method thereof - Google Patents
A kind of anticancer, antitumor Chinese medicine preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of anticancer, antitumor Chinese medicine preparation, raw material include：Toad is dry, Paris polyphylla, Sculellaria barbata, Rabdosia rubescens, subprostrate sophora, radix euphorbiae lantu flower, Moschus, ginseng, Radix Astragali, olibanum, myrrh, Radix Salviae Miltiorrhizae, wherein the parts by weight and additional proportion of each Chinese medicine are：Toad does 0.3-0.8 parts, 0.8-1.5 parts of Paris polyphylla, 3-7 parts of Sculellaria barbata, 3-7 parts of Rabdosia rubescens, 1-3 parts of subprostrate sophora, radix euphorbiae lantu flower 1-1.5 parts, 0.03-0.06 parts of Moschus, 0.5-2 parts of ginseng, 2-4 parts of Radix Astragali, 2-4 parts of olibanum, 2-4 parts of myrrh, 3-7 parts of Radix Salviae Miltiorrhizae.The present invention has the characteristics that convenient to take, treating both manifestation and root cause of disease, curative effect are obvious, toxic side effect is small, price is relatively low, it is mainly used for treating cancer in digestive system and the tumours such as breast cancer, lung cancer, the carcinoma of the rectum, while also there is potential inhibiting effect to other cancers, tumour.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of anticancer, antitumor Chinese medicine preparation and its
Preparation method.
Background technique
Cancer is that human body is (thin in environmental pollution, chemical contamination (chemical toxicant), ionising radiation, free radical toxin, microorganism
Bacterium, fungi, virus etc.) and its various carcinogens, cause such as metabolic toxicities, hereditary capacity, endocrine imbalance, immunologic function disorder
Cause under the action of cancer factor body normal cell occur canceration as a result, normal show as：The cell paraplasm of local organization
And the local lump formed.Cancer is organism normal cell major class disease caused by more reasons, multistage and multiple mutation
Disease, other than preventing early in daily life, once discovery illness and early treatment are crucial.
However, cancer be it is a kind of morbidity and all higher malignant disease of the death rate, the drug that can be prevented and treated at present
And method is all more deficient.Once illness, first is that treatment time is long, the death rate is high, and cancer patient needs several months or several years mostly
Uninterrupted treatment, and can finally defeat the serious illness, the person of getting well is also very few；Second is that therapeutic agent is short, it is costly
It is high, currently, most of anticancer drugs used in China are all not only at high price, the most low incomes of order by introducing from foreign country
Patient hopes medicine step back, powerless to treat, and the main of import anticarcinogen is made of chemical synthesis process, and toxic side effect is larger.
Therefore, how to provide that a kind of therapeutic effect is obvious, toxic side effect is small, relatively low anticancer drug is this to price again
The problem of field technical staff's urgent need to resolve.
Summary of the invention
In view of this, the present invention provides a kind of anticancers, antitumor Chinese medicine preparation and preparation method thereof.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of anticancer, antitumor Chinese medicine preparation, the raw material of the Chinese medicine preparation include：Toad is dry, Paris polyphylla, half
Lotus, Rabdosia rubescens, subprostrate sophora, Moschus, ginseng, Radix Astragali, olibanum, myrrh, Radix Salviae Miltiorrhizae, wherein the parts by weight and addition ratio of each Chinese medicine
Example be：Toad does 0.3-0.8 parts, 0.8-1.5 parts of Paris polyphylla, 3-7 parts of Sculellaria barbata, 3-7 parts of Rabdosia rubescens, 1-3 parts of subprostrate sophora, radix euphorbiae lantu flower
1-1.5 parts, 0.03-0.06 parts of Moschus, 0.5-2 parts of ginseng, 2-4 parts of Radix Astragali, 2-4 parts of olibanum, 2-4 parts of myrrh, 3-7 parts of Radix Salviae Miltiorrhizae.
Preferably, the Chinese medicine preparation by following parts by weight Chinese medicinal composition：Toad does 0.5 part, 1 part of Paris polyphylla, Sculellaria barbata 5
Part, 5 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu spend 1 part, 0.05 part of Moschus, 1 part of ginseng, 3 parts of Radix Astragali, 3 parts of olibanum, 3 parts of myrrh,
5 parts of Radix Salviae Miltiorrhizae.
Preferably, the Chinese medicine preparation by following parts by weight Chinese medicinal composition：Toad is 0.6 part, 1.2 parts, half of Paris polyphylla dry
6 parts of lotus, 6 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu spend 1.5 parts, 0.05 part of Moschus, 1.5 parts of ginseng, 4 parts of Radix Astragali, 3.5 parts of olibanum,
3.5 parts of myrrh, 6 parts of Radix Salviae Miltiorrhizae.
Preferably, the Moschus is muscone.
Based on the above technical solution, the present invention still further there is provided a kind of anticancer, antitumor Chinese medicine preparation
Preparation method includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced simultaneously
Drying；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by its with handled well in step 1
Botanical herbs material mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and do not have
Medicine weighs in proportion after screening, 7-9h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will soak completely
Do not have botanical herbs material；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medicine is obtained after filtering and is mentioned
Object is taken, and the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, then with crushing
Machine is milled to the ultra-micro powder of 300 mesh or more, then is processed into the water-bindered pill Chinese patent medicine preparation conveniently taken.
Preferably, the temperature of low-temperature extraction should be no more than 60 DEG C in the step 3, and low-temperature extraction technology is in low temperature item
Extraction process is completed under part, can make more preferably to save effective component in extraction process, overcomes mentioning of occurring in traditional extraction technique
The dissolution for taking liquid corruption and impurity, greatly reduces extraction solvent.
The effect of a kind of anticancer of the present invention, antitumor Chinese medicine preparation, each Chinese medicinal material is：
Toad do it is sweet in flavor, pungent, it is cool, there is subdhing swelling and detoxicating, analgesic, the effect of diuresis.Toad does for a variety of cancerous swellings or matches
Combination treatment, radiotherapy are for cancer, can not only improve curative effect, moreover it is possible to mitigate side effect, improve blood picture.
Paris polyphylla bitter, it is slightly cold, there is the effect of clearing heat and detoxicating, swelling and pain relieving, cool liver is calmed the frightened.Paris polyphylla is made with cell toxicant
With, induction cancer born of the same parents apoptosis, adjust immune function of human body, influence oncogene expression, the Anticancers effect such as Antineoplastic angiogenesis.
Sculellaria barbata acrid flavour is put down, and has the effect of clearing heat and detoxicating, dissipating stasis and stanching bleeding, inducing diuresis to remove edema.Sculellaria barbata can be by anti-prominent
Proliferation, the apoptosis of induction tumour cell, the immunity for enhancing body, anti-oxidant and truncation tumour for becoming, inhibiting tumour cell
Nutrition supply of cell etc. and play antitumor action.
It is Rabdosia rubescens bitter, sweet, slightly cold, there is the effect of clearing heat and detoxicating, promoting blood circulation and stopping pain, antibacterial, antitumor.Rabdosia rubescens passes through
Suppressing cell reproduction effect；Inhibit the synthesis of cell DNA, RNA and protein；It induces cell apoptosis；The anticarcinogens such as antimutagenic effect
Reason effect.
Subprostrate sophora bitter is trembled with fear, and has the effect of clearing heat and detoxicating, detumescence relieving sore-throat.DNA and RNA of the subprostrate sophora to tumour cell
Synthesis has obvious inhibiting effect, to block the proliferation of tumour cell, can promote lymphocyte transformation, excitation or enhancing lymph are thin
The cytotoxicity of born of the same parents improves T cell ratio, enhancing or adjustment macrophage phagocytic function, moreover it is possible to adjust endocrine, enhance kidney
Thus the function of upper gland cortex influences the occurrence and development of tumour.
Radix euphorbiae lantu spends bitter, pungent, mild-natured, has clearing heat and detoxicating, broken the effect of accumulating desinsection.Two terpene lactones contained in radix euphorbiae lantu flower
Class compound is able to suppress the activity of growth of cancer cells, reaches certain antitumor action.
Muscone's acrid flavour, temperature have the effect of broken product, raw new, sensible.Muscone plays priming in the present invention and enters
Through, guide its medicine to act on disease institute, the function and effect with all medicine rows.
Ginseng is sweet in flavor, slight bitter, and slightly warm in nature has the effect of invigorating qi for relieving desertion, strengthening spleen and tonifying lung, calming heart intelligence development, nourishes blood and promotes the production of body fluid.People
Join and can inhibit growth of tumour cell, inducing apoptosis of tumour cell, the abnormal differentiation of reversing tumor cell, anti-tumor metastasis, simultaneously
It can also be antitumor to achieve the purpose that by improving immunity.
Radix Astragali is sweet in flavor, slightly warm in nature, has the effect of invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema.Radix Astragali can
Body's immunity is adjusted, tumor cell proliferation is resisted, inducing apoptosis of tumour cell resists Nasopharyngeal neoplasms, thus influences
The occurrence and development of tumour.
Olibanum acrid flavour, hardship, temperature have the effect of blood-activating and qi-promoting analgesic, detumescence and promoting granulation.Olibanum has cytotoxicity, lures
Lead the effect of the Anticancers such as cancer born of the same parents apoptosis, Antineoplastic angiogenesis.
The effect of myrrh acrid flavour, hardship are put down, and are had and are dissipated blood and dissolving stasis, promoting blood circulation and hemostasis, detumescence and promoting granulation.Myrrh is thin to C6 glioma
Born of the same parents, A2780 cell, SK-OV-3 cell, Shikawa cell and A2708 cell etc. show significant anti-tumor activity.
It is very strong that olibanum walks the pharmacological property altered, and with myrrh with using, is the key medicine for declaring logical zang-fu differentiation qi and blood, is suitable for all stagnation of the circulation of vital energys
The pain of blood stasis is demonstrate,proved, and the occurrence and development of syndrome of blood stasis and tumour are closely related, therefore the two composition of prescription, for cancer of pancreas, liver cancer,
More malignant tumours such as breast cancer, leukaemia have preferable therapeutic effect.
Radix Salviae Miltiorrhizae smell is bitter, slightly cold, has promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness and restlessness, nourishing blood and tranquilization, help
The effect of strong.Radix Salviae Miltiorrhizae has tumor cell toxic action；The effect of inducing apoptosis of tumour cell；Induce tumor cell differentiation
Effect；Inhibit the invasion and transferance of tumour cell；Enhance the effect of immunity of organisms；The overriding resistance of Radix Salviae Miltiorrhizae active constituent
Property effect, thus influence tumour occurrence and development.
The theoretical basis that a kind of anticancer of the present invention, antitumor Chinese medicine preparation are based on is：The origin cause of formation of cancer is more complicated,
It must be subject to over the course for the treatment of dialectical, accomplish to adjust yin-yang, solid just to help this, dispersing blood stasis dissipating bind, promoting blood circulation analgesic therapy, help is strong.This
The toad of invention effective component is dry to be had effects that kill or inhibits growth of cancer cells, but is depended merely on simply or a few herbal medicines are treated,
Effect is not necessarily ideal, and medication is such as used military forces, it is necessary to human body be regarded as an organic whole, yin-yang reconciles, and soldier will pull together, and reverses
Its pathomechanism, prevents the generation of complication, so that basic treatment is stepped into, whole to restore, the optimal treatment boundary for the treatment of both manifestation and root cause of disease.
Beneficial effects of the present invention are：
Chinese medicine preparation of the present invention is made of 12 taste Chinese medicine materials, with the root, stem, Ye Jishu of high-quality pure natural plant
Rouge, animal medicinal material are refined using traditional handicraft combination modern pharmaceutical technology.Wherein, toad is dry, muscone, half
The Chinese medicine composition that lotus, Rabdosia rubescens, subprostrate sophora and radix euphorbiae lantu are spent has effects that clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, promoting the circulation of qi dissipating bind, can have
The kill cancer cell of effect simultaneously has good inhibiting effect to cancer cell, on this basis, the present invention be aided with simultaneously ginseng, Radix Salviae Miltiorrhizae,
This kind of activating microcirculation and removing stasis medicinal of Radix Astragali, the carbuncle that disappears analgesic, help is strong, enhances the Chinese medicine of immunity of organisms, this kind of promoting blood circulationization of olibanum, myrrh
The stasis of blood, the Chinese medicine of analgesic therapy myogenic reach and human body are helped to restore, adjust human body and exempt from for nourishing, the analgesic in cancer treatment procedure
Epidemic disease function is a kind of lower anticancer drug of toxic side effect the effect of killing and inhibit growth of cancer cells.
According to clinical verification, the present invention have convenient to take, treating both manifestation and root cause of disease, curative effect is obvious, toxic side effect is small, price is relatively low
The features such as lower, will such as be taken for a long time by the course for the treatment of, have the curative effect of thorough radical cure.The Chinese medicine preparation is mainly used for treating breast cancer, lung
The cancer in digestive system such as cancer, the carcinoma of the rectum and tumour, while also there is potential inhibiting effect to other cancers, tumour.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 attached drawing is relevant animal experimental data line chart one provided by the invention；
Fig. 2 attached drawing is relevant animal experimental data line chart two provided by the invention；
Fig. 3 attached drawing is relevant animal experimental data column diagram provided by the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of anticancer of the invention, antitumor Chinese medicine preparation, the Chinese medicine preparation are made of following weight：Toad
0.3 part dry, 0.8 part of Paris polyphylla, 3 parts of Sculellaria barbata, 3 parts of Rabdosia rubescens, 1 part of subprostrate sophora, radix euphorbiae lantu spend 1 part, 0.03 part of Moschus, ginseng 0.5
Part, 2 parts of Radix Astragali, 2 parts of olibanum, 2 parts of myrrh, 3 parts of Radix Salviae Miltiorrhizae.
The preparation method of the Chinese medicine preparation includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced simultaneously
Drying；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by its with handled well in step 1
Botanical herbs material mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and do not have
Medicine weighs in proportion after screening, 7h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will be totally submerged
The temperature of botanical herbs material, low-temperature extraction is no more than 60 DEG C；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medicine is obtained after filtering and is mentioned
Object is taken, and the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, then with crushing
Machine is milled to the ultra-micro powder of 300 mesh or more, then is processed into water-bindered pill Chinese patent medicine preparation.
Embodiment 2：
A kind of anticancer of the invention, antitumor Chinese medicine preparation, the Chinese medicine preparation are made of following weight：Toad
0.5 part dry, 1 part of Paris polyphylla, 5 parts of Sculellaria barbata, 5 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu spend 1.2 parts, 0.05 part of muscone, ginseng
1 part, 3 parts of Radix Astragali, 3 parts of olibanum, 3 parts of myrrh, 5 parts of Radix Salviae Miltiorrhizae.
The preparation method of the Chinese medicine preparation includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced simultaneously
Drying；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by its with handled well in step 1
Botanical herbs material mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and do not have
Medicine weighs in proportion after screening, 8h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will be totally submerged
The temperature of botanical herbs material, low-temperature extraction is no more than 60 DEG C；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medicine is obtained after filtering and is mentioned
Object is taken, and the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, then with crushing
Machine is milled to the ultra-micro powder of 300 mesh or more, then is processed into water-bindered pill Chinese patent medicine preparation.
Embodiment 3：
A kind of anticancer of the invention, antitumor Chinese medicine preparation, the Chinese medicine preparation are made of following weight：Toad
0.6 part dry, 1.2 parts of Paris polyphylla, 6 parts of Sculellaria barbata, 6 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu spend 1.3 parts, 0.05 part of Moschus, ginseng
1.5 parts, 4 parts of Radix Astragali, 3.5 parts of olibanum, 3.5 parts of myrrh, 6 parts of Radix Salviae Miltiorrhizae.
The preparation method of the Chinese medicine preparation includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced simultaneously
Drying；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by its with handled well in step 1
Botanical herbs material mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and do not have
Medicine weighs in proportion after screening, 8h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will be totally submerged
The temperature of botanical herbs material, low-temperature extraction is no more than 60 DEG C；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medicine is obtained after filtering and is mentioned
Object is taken, and the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, then with crushing
Machine is milled to the ultra-micro powder of 300 mesh or more, then is processed into water-bindered pill Chinese patent medicine preparation.
Embodiment 4：
A kind of anticancer of the invention, antitumor Chinese medicine preparation, the Chinese medicine preparation are made of following weight：Toad
0.8 part dry, 1.5 parts of Paris polyphylla, 7 parts of Sculellaria barbata, 7 parts of Rabdosia rubescens, 3 parts of subprostrate sophora, radix euphorbiae lantu spend 1.5 parts, 0.06 part of Moschus, ginseng 2
Part, 4 parts of Radix Astragali, 4 parts of olibanum, 4 parts of myrrh, 7 parts of Radix Salviae Miltiorrhizae.
The preparation method of the Chinese medicine preparation includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced simultaneously
Drying；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by its with handled well in step 1
Botanical herbs material mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and do not have
Medicine weighs in proportion after screening, 9h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will be totally submerged
The temperature of botanical herbs material, low-temperature extraction is no more than 60 DEG C；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medicine is obtained after filtering and is mentioned
Object is taken, and the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, then with crushing
Machine is milled to the ultra-micro powder of 300 mesh or more, then is processed into water-bindered pill Chinese patent medicine preparation.
The following are a kind of anticancers of the present invention, the relevant animal experimental studies results of antitumor Chinese medicine preparation：
It takes that 80 monthly ages are close, tumor-bearing mice similar in weight is tested, is divided into tetra- groups of A, B, C, D, wherein A
Group is control group, i.e., is not administered；B group is chemotherapy group, only injects adriamycin (DOX)；C group is Chinese medicine group, takes orally Chinese medicine of the present invention；
D group is chemotherapy+Chinese medicine group, injection adriamycin+take orally Chinese medicine (DOX+CTM) of the present invention.
1, experiment observes each group tumor-bearing mice after starting, it is found that the mouse of A group control group and C group Chinese medicine group is active
It is active, but B group chemotherapy group (adriamycin group) and D group chemotherapy add the mouse vigor of Chinese medicine group (adriamycin+Chinese medicine) poor, do not like to live
Dynamic, feed is few.B group chemotherapy group mouse respectively the 13rd day, the 17th day, the 19th day and the 25th day each dead 1, D group chemotherapy adds
Chinese medicine group the 20th day and the 24th day each dead 1, the mouse of A group control group and C group Chinese medicine group is without death.It is sent out through research
It is existing, B group chemotherapy group and D group chemotherapy+Chinese medicine group mouse vigor is poor is derived mainly from chemotherapeutic with the higher result of the death rate
Toxic side effect.
2, after experiment starts, the average external volume of the tumour of an each group mouse is recorded every three days, as shown in Fig. 1,
Illustrate that the average external volume of the tumour of each group mouse changes with time situation.
As shown in Figure 1, the rapid growth of the tumor of A group control group, at the 25th day, the average external volume of tumour was from 99.7mm3
Grow into 2701mm3, increase about 27 times.B group chemotherapy group only increases compared with the 0th day in the average external volume of the 25th day tumour
Added 9.3 times, i.e., at the 25th day, the gross tumor volume of B group chemotherapy group was only equivalent to the 34% of A group control group tumor average volume,
Illustrate that chemotherapy (adriamycin) significantly inhibits the growth of tumour.C group Chinese medicine group at the 25th day than the 0th day when
Tumor average volume increases 6.9 times, illustrates that Chinese medicine of the present invention also has apparent inhibiting effect to the growth of tumour, and it presses down
It makes also high of the inhibiting effect than B group chemotherapy (adriamycin).D group chemotherapy+Chinese medicine group tumour is that the speed of growth is smaller,
Tumor average volume when at 25 days than the 0th day increases 5.1 times, i.e. inhibiting effect ratio of the D group chemotherapy+Chinese medicine to tumour growth
Independent chemotherapy and independent Chinese medicine it is bigger, illustrate that chemotherapy and Chinese medicine drug combination have cumulative effect to the inhibiting effect of tumour growth
Fruit.
3, after experiment starts, the average weight of an each group mouse is recorded every three days, as shown in Fig. 2, which illustrate
The average weight of each group mouse changes with time situation.
As shown in Figure 2, the average weight of A group control group mice is increased slightly at any time, but the mouse of B group chemotherapy group is flat
Equal weight significantly reduces.The reduction of this weight is as caused by the toxic side effect of adriamycin, because the toxic side effect of chemotherapy is logical
The reduction of weight can often be caused.And the variation of the average weight of C group Chinese medicine group mouse and approaching for A group control group, i.e. weight are not
Only do not decline, be also increased slightly, illustrates that Chinese medicine of the present invention is very small to the toxic side effect of mouse.D group Chinese medicine+chemotherapy group mouse
Changes of weight it is similar with B group chemotherapy group, illustrate that the decline of the weight of this group is as caused by adriamycin.
4, the 25th day upon administration, mouse is put to death, and tumour is taken out in dissection, is weighed, the average weight of the tumour of each group
Amount is as shown in Fig. 3 figure.A group control group, B group chemotherapy group, the average weight of C group Chinese medicine group and D group Chinese medicine+chemotherapy group tumour
Ratio is 1：0.35：0.31：0.24, it is almost the same with the volume ratio of each group tumour.
By above-mentioned relevant animal experimental studies results it can be shown that a kind of anticancer of the present invention, antitumor Chinese medicine preparation tool
The characteristics of toxic side effect is small, can effectively kill and inhibit growth of cancer cells.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.To the upper of the disclosed embodiments
It states bright, enables those skilled in the art to implement or use the present invention.Various modifications to these embodiments are to ability
Will be apparent for the professional technician in domain, the general principles defined herein can not depart from it is of the invention
In the case where spirit or scope, realize in other embodiments.Therefore, the present invention be not intended to be limited to it is shown in this article these
Embodiment, and it is to fit to the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. a kind of anticancer, antitumor Chinese medicine preparation, which is characterized in that the raw material of the Chinese medicine preparation include：Toad does, again
Building, Sculellaria barbata, Rabdosia rubescens, subprostrate sophora, radix euphorbiae lantu flower, Moschus, ginseng, Radix Astragali, olibanum, myrrh, Radix Salviae Miltiorrhizae, wherein the weight of each Chinese medicine
Amount number and additional proportion are：Toad does 0.3-0.8 parts, 0.8-1.5 parts of Paris polyphylla, 3-7 parts of Sculellaria barbata, 3-7 parts of Rabdosia rubescens, mountain beans
1-3 parts of root, radix euphorbiae lantu flower 1-1.5 parts, 0.03-0.06 parts of Moschus, 0.5-2 parts of ginseng, 2-4 parts of Radix Astragali, 2-4 parts of olibanum, myrrh 2-4
Part, 3-7 parts of Radix Salviae Miltiorrhizae.
2. a kind of anticancer according to claim 1, antitumor Chinese medicine preparation, it is characterised in that：The Chinese medicine preparation by
The Chinese medicinal composition of following parts by weight：Toad does 0.5 part, 1 part of Paris polyphylla, 5 parts of Sculellaria barbata, 5 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu flower
1 part, 0.05 part of Moschus, 1 part of ginseng, 3 parts of Radix Astragali, 3 parts of olibanum, 3 parts of myrrh, 5 parts of Radix Salviae Miltiorrhizae.
3. a kind of anticancer according to claim 1, antitumor Chinese medicine preparation, it is characterised in that：The Chinese medicine preparation by
The Chinese medicinal composition of following parts by weight：Toad does 0.6 part, 1.2 parts of Paris polyphylla, 6 parts of Sculellaria barbata, 6 parts of Rabdosia rubescens, 2 parts of subprostrate sophora, radix euphorbiae lantu
Spend 1.5 parts, 0.05 part of Moschus, 1.5 parts of ginseng, 4 parts of Radix Astragali, 3.5 parts of olibanum, 3.5 parts of myrrh, 6 parts of Radix Salviae Miltiorrhizae.
4. a kind of anticancer according to claim 1-3, antitumor Chinese medicine preparation, it is characterised in that：The musk deer
Perfume is muscone.
5. the preparation method of a kind of anticancer, antitumor Chinese medicine preparation, which is characterized in that the dosage form of the Chinese medicine preparation is the water-bindered pill
Preparation, preparation method includes the following steps：
Step 1：Botanical herbs material Paris polyphylla, ginseng, Radix Astragali and the Radix Salviae Miltiorrhizae for weighing root, stem class in proportion, are sliced and are dried
It is dry；
Step 2：Weigh in proportion animal class Chinese medicine toad is dry and Moschus, by itself and the plant handled well in step 1
Chinese medicine mix and to beat powder spare；
Step 3：By the botanical herbs material Rabdosia rubescens of grass and resinae, Sculellaria barbata, subprostrate sophora, radix euphorbiae lantu flower, olibanum and myrrh warp
It is weighed in proportion after crossing screening, 7-9h is then impregnated using ethyl alcohol as extractant low-temperature extraction, wherein ethyl alcohol will be totally submerged plant
Object Chinese medicine；
Step 4：The extract liquor obtained in above-mentioned steps three is subjected to precipitating reflux, corresponding Chinese medical extract is obtained after filtering,
And the extract is dried, beats powder；
Step 5：Step 2 is uniformly mixed under sterile, dustless environment with the medicinal powder in step 4, it then will with pulverizer
Its ultra-micro powder for being milled to 300 mesh or more, then it is processed into water-bindered pill Chinese patent medicine preparation.
6. a kind of anticancer according to claim 5, the preparation method of antitumor Chinese medicine preparation, it is characterised in that：It is described
The temperature of low-temperature extraction should be no more than 60 DEG C in step 3.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787260A (en) * | 2019-11-08 | 2020-02-14 | 熊兴宣 | Medicine for treating lung cancer and preparation method thereof |
| CN113694137A (en) * | 2021-09-14 | 2021-11-26 | 临沧宏胜生物科技开发有限公司 | Traditional Chinese medicine composition for inhibiting lung cancer cell metastasis and preparation method thereof |
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| CN101417067A (en) * | 2007-10-23 | 2009-04-29 | 雷海民 | Medicine combination with anti-tumor function |
| CN101530468A (en) * | 2008-03-14 | 2009-09-16 | 北京汉潮联创中药科技有限公司 | Chinese medicinal preparation for treating gum cancer |
| CN107661392A (en) * | 2017-10-24 | 2018-02-06 | 大连大学 | A kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof |
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2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417067A (en) * | 2007-10-23 | 2009-04-29 | 雷海民 | Medicine combination with anti-tumor function |
| CN101530468A (en) * | 2008-03-14 | 2009-09-16 | 北京汉潮联创中药科技有限公司 | Chinese medicinal preparation for treating gum cancer |
| CN107661392A (en) * | 2017-10-24 | 2018-02-06 | 大连大学 | A kind of Chinese medicine compound prescription for treating cancer of the esophagus and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110787260A (en) * | 2019-11-08 | 2020-02-14 | 熊兴宣 | Medicine for treating lung cancer and preparation method thereof |
| CN113694137A (en) * | 2021-09-14 | 2021-11-26 | 临沧宏胜生物科技开发有限公司 | Traditional Chinese medicine composition for inhibiting lung cancer cell metastasis and preparation method thereof |
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Application publication date: 20181116 |