CN105232659B - A kind of Chinese medicine composition of soothing liver and strengthening spleen and preparation method thereof - Google Patents
A kind of Chinese medicine composition of soothing liver and strengthening spleen and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of soothing liver and strengthening spleen Chinese medicine compositions and preparation method thereof, it is characterised in that the bulk pharmaceutical chemicals of the Chinese medicine composition are：60 200 parts of stir-baked RADIX BUPLEURI with vinegar, 100 200 parts of Poria cocos, 200 400 parts of Radix Astragali, 60 200 parts of Radix Angelicae Sinensis, 80 200 parts of Radix Paeoniae Alba, 100 220 parts of rhizoma atractylodis macrocephalae, 100 180 parts of cortex albiziae, 100 180 parts of the fruit of glossy privet, 80 180 parts of Radix Polygalae, 60 150 parts of rhodiola root.The invention also discloses preparation method, Chinese medicine composition of the invention can soothing liver and strengthening spleen, benefiting qi and nourishing blood, remove weary tranquilizing the mind.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and detection method, more particularly in a kind of soothing liver and strengthening spleen
Drug composition and preparation method thereof and detection method.
Background technology
With the development of modern society, the work of people and life stress increasingly increase, therefore have the function of soothing liver and strengthening spleen
Drug and food be increasingly valued by people and favor.Currently, soothing liver and strengthening spleen drug variety is various, but curative effect and pay no attention to
Think, most drugs need to take longer time, could slightly have curative effect.
China's traditional Chinese medicine has Small side effects, the outstanding feature of conditioning functions, the problems such as can effectively improve liver depression.
Invention content
The purpose of the present invention is to provide a kind of soothing liver and strengthening spleen Chinese medicine composition, another object of the present invention is to provide this
The preparation method of Chinese medicine composition.
Purpose of the present invention is to what is be achieved through the following technical solutions：
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：60-200 parts of stir-baked RADIX BUPLEURI with vinegar, 100-200 parts of Poria cocos, Radix Astragali 200-
400 parts, 60-200 parts of Radix Angelicae Sinensis, 80-200 parts of Radix Paeoniae Alba, 100-220 parts of rhizoma atractylodis macrocephalae, 100-180 parts of cortex albiziae, fruit of glossy privet 100-180
Part, 80-180 parts of Radix Polygalae, 60-150 parts of rhodiola root.
Technical solution of the present invention can be：
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：80-160 parts of stir-baked RADIX BUPLEURI with vinegar, 120-180 parts of Poria cocos, Radix Astragali 220-
380 parts, 80-160 parts of Radix Angelicae Sinensis, 100-180 parts of Radix Paeoniae Alba, 120-200 parts of rhizoma atractylodis macrocephalae, 120-170 parts of cortex albiziae, fruit of glossy privet 120-
170 parts, 100-160 parts of Radix Polygalae, 80-120 parts of rhodiola root.
Technical solution of the present invention is preferably：
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：100 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, 300 parts of Radix Astragali, Radix Angelicae Sinensis
100 parts, 150 parts of Radix Paeoniae Alba, 150 parts of rhizoma atractylodis macrocephalae, 150 parts of cortex albiziae, 150 parts of the fruit of glossy privet, 120 parts of Radix Polygalae, 100 parts of rhodiola root.
Technical solution of the present invention can also be：
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：90 parts of stir-baked RADIX BUPLEURI with vinegar, 130 parts of Poria cocos, 230 parts of Radix Astragali, Radix Angelicae Sinensis 90
Part, 110 parts of Radix Paeoniae Alba, 140 parts of rhizoma atractylodis macrocephalae, 130 parts of cortex albiziae, 120 parts of the fruit of glossy privet, 130 parts of Radix Polygalae, 90 parts of rhodiola root.
Technical solution of the present invention can also be：
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：150 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, 360 parts of Radix Astragali, Radix Angelicae Sinensis
120 parts, 160 parts of Radix Paeoniae Alba, 160 parts of rhizoma atractylodis macrocephalae, 140 parts of cortex albiziae, 160 parts of the fruit of glossy privet, 150 parts of Radix Polygalae, 110 parts of rhodiola root.
The Chinese medicine composition of the present invention, dosage form are the oral preparations such as capsule, granule, tablet, pill, powder.
The preparation method of Chinese medicine composition of the present invention is：Whole flavour of a drug add water to cook, and filter, and concentrate, dry, add auxiliary material
In right amount, mixing, packing.
The preparation method of Chinese medicine composition of the present invention is preferably：Whole flavour of a drug add water to cook 2 times, first time 60min, the
2 30min are filtered, and are concentrated, dry, add right amount of auxiliary materials, mixing to pelletize, packing.
The preparation method of Chinese medicine composition of the present invention can be：Whole flavour of a drug add water to cook 2 times, first time 60min, the
2 30min are filtered, and are concentrated, and are spray-dried, packing.
The preparation method of Chinese medicine composition of the present invention can also be：Whole flavour of a drug add water to cook, and filter, and concentration adds second
Alcohol, alcohol precipitation, supernatant fling to ethyl alcohol, and concentration adds right amount of auxiliary materials, dry, and mixing is pelletized, packing.
The card of the present invention that cure mainly that is formulated is caused by liver depression, and Shuganjianpi Formula is hepatic depression and blood deficiency, the card of the dysfunction of the spleen in transport
And it sets.Liver is the viscus of storing blood, and property happiness, which is adjusted, to be reached and main catharsis, body the moon sun.If seven feelings pent-ups, liver can be made to lose item and reached, irritability is not defeated,
Mood irritability rises therewith demonstrate,proving.Cloudy blood secretly consumes or the source of vital function is insufficient, and liver body, which loses, supports, and insomnia and dreamful sleep can all risen therewith demonstrate,proving.
Body tiredness is tired, is the powerless event of spleen deficiency transporting.Soothing liver-qi stagnation at this time, tonifying Qi and blood are also generally applicable.The existing stir-baked RADIX BUPLEURI with vinegar of we is soothing the liver
Xie Yu, and have Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood and liver.Especially the fragrance of Radix Angelicae Sinensis can promoting the circulation of qi, it is sweet in flavor can emergency, even more hepatic depression and blood deficiency wants
Medicine.Rhizoma Atractylodis Macrocephalae, Poria cocos invigorating the spleen dehumidifying, make transporting have the right, and qi and blood is active, Radix Astragali and Rhizoma Atractylodis Macrocephalae compatibility, can invigoration spleen qi, match with Radix Angelicae Sinensis
5, it can qi-supplementing, blood-engendering.Cortex albiziae, Radix Polygalae, antitoxic heart-soothing and sedative solution are strongly fragrant.The fruit of glossy privet tonifies the liver and kidney.Rhodiola root, strengthening healthy qi, tonifying Qi are supported
Blood, modern pharmacological studies have shown that having antifatigue, antioxidation.The five tastes on this have the work(supported and assist in though being allowed to product for assistant.
Such compatibility, liver and spleen are simultaneously controlled, and qi and blood is taken into account, and legislation is comprehensive, and medication is thoughtful.
The present invention Chinese medicine composition can soothing liver and strengthening spleen, benefiting qi and nourishing blood, remove weary tranquilizing the mind, for stagnation of liver-QI with deficiency of the spleen, insufficiency of vital energy and blood,
And tired tired, insomnia and dreamful sleep is dedicated one's life to, mood irritability person.Clinical trial shows that improvement is notable.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
1, prescription：
Stir-baked RADIX BUPLEURI with vinegar 100g, Poria cocos 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, rhizoma atractylodis macrocephalae 150g, cortex albiziae 150g,
Fruit of glossy privet 150g, Radix Polygalae 120g, rhodiola root 100g.
2. preparation method：
Whole flavour of a drug add water to cook 2 times, first time 60min, the 2nd 30min, filter, and concentrate, dry, add right amount of auxiliary materials,
Mixing, granulation, packing capsule to get.
Embodiment 2
1, prescription：
Stir-baked RADIX BUPLEURI with vinegar 90g, Poria cocos 130g, Radix Astragali 230g, Radix Angelicae Sinensis 90g, Radix Paeoniae Alba 110g, rhizoma atractylodis macrocephalae 140g, cortex albiziae 130g, female
Loyal sub- 120g, Radix Polygalae 130g, rhodiola root 90g.
2. preparation method：
Whole flavour of a drug add water to cook 2 times, first time 60min, the 2nd 30min, filter, and concentrate, and are spray-dried, packing, i.e.,
.
Embodiment 3
1, prescription：
Stir-baked RADIX BUPLEURI with vinegar 150g, Poria cocos 150g, Radix Astragali 360g, Radix Angelicae Sinensis 120g, Radix Paeoniae Alba 160g, rhizoma atractylodis macrocephalae 160g, cortex albiziae 140g,
Fruit of glossy privet 160g, Radix Polygalae 150g, rhodiola root 110g.
2. preparation method：
Whole flavour of a drug add water to cook, and filter, and concentration adds ethyl alcohol, alcohol precipitation, supernatant to fling to ethyl alcohol, concentrates, and add auxiliary material suitable
Amount, dry, mixing, granulation, packing to get.
Embodiment 4
1, prescription：
Stir-baked RADIX BUPLEURI with vinegar 100g, Poria cocos 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, rhizoma atractylodis macrocephalae 150g, cortex albiziae 150g,
Fruit of glossy privet 150g, Radix Polygalae 120g, rhodiola root 100g.
2. preparation method：
Whole flavour of a drug add water to cook 2 times, filter, and concentration adds ethyl alcohol to 60%, and alcohol precipitation, supernatant flings to ethyl alcohol, concentration,
Add right amount of auxiliary materials, dry, mixing, granulation, packing to get.
Embodiment 5：The clinical research of soothing liver and strengthening spleen
1.1 test method：Multicenter, random, double blind, placebo controlled clinical trial, total sample size are 118, treatment
Group 59, control group 59.Group technology：Research is used and is compareed between group between treatment group and control group.
1.2, case selection
1.2.1 diagnosis and staging scale：With reference to NCCN breast cancer clinical practice guidelines.
1.2.2 inclusion criteria：
2.1 have the women with breast cancer treat-and-release patient of clear pathological diagnosis
After 2.2 mammary cancer radical operation resections within 5 years, terminate radiotherapy or chemotherapy 1 month or more
2.3 confirm through clinical and iconography without tumor recurrence or transfer.
2.4 ECOG scorings are 0-2 points
1.3 administrated method
Chinese medicine group：The sample prepared using the method for embodiment 1, each primary daily morning and evening, one bag (4g) every time, warm water
It takes after mixing it with water.Treatment course surrounding.
Control group：Placebo granulation, it is each primary daily morning and evening, one bag every time, warm boiled water.Treatment course surrounding.
2 test results：
2.1 baseline characteristic
Baseline characteristic main contents are the age of patient, education degree, marital status, operating time, histological type, clinic
Classification, therapy.Since 3 research objects are not included in statistical analysis, we carry out baseline characteristic analysis to 115 patients.
Measurement data uses two sample t-tests, classification and ranked data to use Chi-square Test in Baseline Data.
2.2 experiment tables：Evaluation table
2.2 result
2 two groups of tcm symptom scorings of table are compared
When test result shows to treat 4 weeks, treatment group improves apparent, specific statistical significance (P ＜ compared with control group
0.05).Illustrate that Chinese medicine group can treat the card of stagnation of liver-QI with deficiency of the spleen of patient with breast cancer.
Embodiment 6:Safety evaluatio
Foundation《New Chinese medicine guideline of clinical investigations》, originally studying and defining safety evaluatio project includes：Blood routine, urine
Routine, just routine, hepatic and renal function, electrocardiogram, to evaluate the function and adverse events of the important organs such as the heart, liver, kidney, peripheral hemogram
Record.Adverse events are defined as any unexpected adverse reaction that may occur over the course for the treatment of, but it has no with medication
Inevitable causality.Serious adverse events are defined as referring to event associated with dead, need to be hospitalized diagnosis and treatment, life-threatening etc..
Clinical scale carried out to Liver and kidney function, electrocardiogram, stool and urine result, it is such as normal, abnormal but without clinical meaning, different
Often and there is clinical meaning, do not look into, using Chi-square Test, when frequency ＜ 5 uses rank sum test.Display：Baseline and at 4 weeks, treatment
Group and control group security inspection no difference of science of statistics (P ＞ 0.05).
Claims (11)
1. a kind of soothing liver and strengthening spleen Chinese medicine composition, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：Stir-baked RADIX BUPLEURI with vinegar
60-200 parts, 100-200 parts of Poria cocos, 200-400 parts of Radix Astragali, 60-200 parts of Radix Angelicae Sinensis, 80-200 parts of Radix Paeoniae Alba, rhizoma atractylodis macrocephalae 100-220
Part, 100-180 parts of cortex albiziae, 100-180 parts of the fruit of glossy privet, 80-180 parts of Radix Polygalae, 60-150 parts of rhodiola root.
2. Chinese medicine composition as described in claim 1, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：Vinegar
80-160 parts of radix bupleuri, 120-180 parts of Poria cocos, 220-380 parts of Radix Astragali, 80-160 parts of Radix Angelicae Sinensis, 100-180 parts of Radix Paeoniae Alba, rhizoma atractylodis macrocephalae
120-200 parts, 120-170 parts of cortex albiziae, 120-170 parts of the fruit of glossy privet, 100-160 parts of Radix Polygalae, 80-120 parts of rhodiola root.
3. Chinese medicine composition as claimed in claim 2, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：Vinegar
100 parts of radix bupleuri, 150 parts of Poria cocos, 300 parts of Radix Astragali, 100 parts of Radix Angelicae Sinensis, 150 parts of Radix Paeoniae Alba, 150 parts of rhizoma atractylodis macrocephalae, 150 parts of cortex albiziae, female
Loyal 150 parts of son, 120 parts of Radix Polygalae, 100 parts of rhodiola root.
4. Chinese medicine composition as claimed in claim 2, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：Vinegar
90 parts of radix bupleuri, 130 parts of Poria cocos, 230 parts of Radix Astragali, 90 parts of Radix Angelicae Sinensis, 110 parts of Radix Paeoniae Alba, 140 parts of rhizoma atractylodis macrocephalae, 130 parts of cortex albiziae, glossy privet
120 parts of son, 130 parts of Radix Polygalae, 90 parts of rhodiola root.
5. Chinese medicine composition as claimed in claim 2, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are：Vinegar
150 parts of radix bupleuri, 150 parts of Poria cocos, 360 parts of Radix Astragali, 120 parts of Radix Angelicae Sinensis, 160 parts of Radix Paeoniae Alba, 160 parts of rhizoma atractylodis macrocephalae, 140 parts of cortex albiziae, female
Loyal 160 parts of son, 150 parts of Radix Polygalae, 110 parts of rhodiola root.
6. the Chinese medicine composition as described in claim 1 to 5 is any, which is characterized in that its dosage form is oral preparation.
7. Chinese medicine composition as claimed in claim 6, which is characterized in that the oral preparation is capsule, granule, piece
Agent, pill, powder.
8. the preparation method of the Chinese medicine composition as described in claim 1 to 5 is any, it is characterised in that this method is：Whole medicines
Taste adds water to cook, and filters, and concentrates, dry, adds right amount of auxiliary materials, mixing, packing.
9. the preparation method of Chinese medicine composition as claimed in claim 6, it is characterised in that this method is：Whole flavour of a drug add decocting
It boils 2 times, first time 60min, the 2nd 30min, filters, concentrate, it is dry, add right amount of auxiliary materials, mixing to pelletize, packing.
10. the preparation method of the Chinese medicine composition as described in claim 1 to 5 is any, it is characterised in that this method is：Whole medicines
Taste adds water to cook 2 times, first time 60min, the 2nd 30min, filters, and concentrates, and is spray-dried, packing.
11. the preparation method of the Chinese medicine composition as described in claim 1 to 5 is any, it is characterised in that this method is：Whole medicines
Taste adds water to cook, and filters, and concentration adds ethyl alcohol, alcohol precipitation, supernatant to fling to ethyl alcohol, concentrates, adds right amount of auxiliary materials, dry, mixing, system
Grain, packing.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
| CN103736037A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicine for treating chronic fatigue syndrome and preparation method thereof |
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2015
- 2015-11-10 CN CN201510761796.7A patent/CN105232659B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
| CN103736037A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicine for treating chronic fatigue syndrome and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 逍遥散新用;马红侠;《新中医》;20050430;第37卷(第04期);83 * |
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