CN102631492B - Chinese medicinal composition for improving immunity and resisting fatigue - Google Patents
Chinese medicinal composition for improving immunity and resisting fatigue Download PDFInfo
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- CN102631492B CN102631492B CN201210121969.5A CN201210121969A CN102631492B CN 102631492 B CN102631492 B CN 102631492B CN 201210121969 A CN201210121969 A CN 201210121969A CN 102631492 B CN102631492 B CN 102631492B
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Abstract
The invention relates to a health care product composition for improving the immunity of a human organism and resisting fatigue. The composition consists of the active ingredients of ginseng, saffron, spirulina and cordyceps. The composition has the effects of enhancing the immunity of the organism, resisting fatigue and building the body of a patient, and has remarkable curative effects and mild effects.
Description
Technical field
The present invention relates to a kind of collaborative Chinese medicine composition that improves body immunity, resisting fatigue and kidney invigorating and Yang strengthening function that has.
Technical background
Along with socioeconomic continuous development, the raising day by day of people's living standard, people increase gradually to the degree of keeping a grip on of health, live in now all be, we receive many outside threats easily at everyone health, comprise air pollution, video pollution, environmental pollution, operating pressure, economic pressures, bacterial virus, improper diet etc.Moreover, because the variation of city work, rhythm of life is easy to make the people to produce confirmed fatigue, i.e. sub-health state, the factor of all these unfavorable health can be made us spiritual usually and can not concentrate, hypomnesis, often indolent and listless, old and feeble ahead of time.Therefore improve autoimmunity, the ability that strengthens the various unfavorable health factors of antagonism is most important.
The health product that are used for enhancing human body immunity power on the market are of a great variety at present, but action effect is uneven.
Summary of the invention
The technical problem to be solved in the present invention is: the Chinese medicine composition that the purpose of this invention is to provide a kind of enhancing human body immunity power, resisting fatigue and kidney invigorating and Yang strengthening function.By being main Chinese crude drug with Radix Ginseng, Stigma Croci, spirulina and Cordyceps, by mutual synergistic function, in the hope of improving resistance against diseases, enhance immunity effect, the engineering of alleviating physical fatigue and kidney invigorating and Yang strengthening function.
For solving the problems of the technologies described above, the invention provides a kind of collaborative Halth-care composition that improves body immunity, resisting fatigue that has, it is characterized in that described compositions comprises a kind of Halth-care composition that has Synergistic raising human body immunity of organisms, resisting fatigue and have kidney invigorating and Yang strengthening function of active component, is characterized in that described compositions comprises Radix Ginseng, Stigma Croci, spirulina, Cordyceps.In the active component by weight: Radix Ginseng 3-65 part, Stigma Croci 2-60 part, spirulina 4-65 part, Cordyceps 4-65 part.Preferably, Radix Ginseng 4-50 part, Stigma Croci 3-45 part, spirulina 7-50 part, Cordyceps 8-45 part.
Preferably, the weight proportion of each component is: 65 parts of Radix Ginsengs, 60 parts of Stigma Crocis, 65 parts of spirulinas, 65 parts of Cordycepses.
Preferably, the weight proportion of each component is: Radix Ginseng is 3 parts, and Stigma Croci is 2 parts, 4 parts of spirulinas, 4 parts of Cordycepses.
The weight proportion of preferred each component is: 20 parts of Radix Ginsengs, 12 parts of Stigma Crocis, 25 parts of spirulinas, 15 parts of Cordycepses.
The weight proportion of preferred each component is: 50 parts of Radix Ginsengs, 45 parts of Stigma Crocis, 50 parts of spirulinas, 45 parts of Cordycepses.
Radix Ginseng: related Radix Ginseng refers to the general name of a kind of herbaceos perennial of the Umbellales Araliaceae Radix Ginseng Panax of family among the present invention, comprises Radix Ginseng Rubra, Radix Ginseng, Radix Panacis Quinquefolii (Radix Panacis Quinquefolii), Radix Glehniae, Radix Codonopsis and Radix Pseudostellariae etc.Radix Ginseng among the present invention comprises through processing and refines back Radix Ginseng extract, various forms in grinding descendant's pure extract powder or Radix Ginseng growth course.
Stigma Croci: involved in the present invention to Stigma Croci (claiming Stigma Croci, Stigma Croci again), be the perennial flowers of a kind of Liliales Iridaceae crocus.Stigma Croci among the present invention comprises crocein powder after grinding, obtains Stigma Croci extracts or croceous other processing forms by various processes.
Spirulina: involved in the present invention to spirulina refer to belong to a class rudimentary plant in Cyanophyta, Cyanophyceae, hormocystangium order, Oscillariaceae, the Spirullina, mainly comprise spirulina maxim, spirulina plalensis.Spirulina among the present invention comprises other processing forms of refining rear screw algae extract or spirulina through processing.
Cordyceps: related Cordyceps refers to the fungus (Cordyceps) and the bacterium worm coalition that larva forms of Clavicipitaceae among the present invention under specific condition, comprising: Cordyceps, Cordyceps hawkesii Gary, Cordyceps liangshanensis Zang Hu et Liu, the Xinjiang Cordyceps, the branch Cordyceps, leaves of pulse plants gram Cordyceps, Cordyceps militaris (L.) Link., the Wuyi Mountain Cordyceps, the dragon's cave-stalactite cave Cordyceps, the Zhangjiajie Cordyceps, big cat head Cordyceps, many shells Cordyceps, gentle handle Cordyceps, sagging Cordyceps, the Jiangxi Cordyceps, the Sichuan Cordyceps, Cordyceps oxycephala, bar grace Cordyceps, the Guizhou Cordyceps, the Chishui Cordyceps, the Dermaptera Cordyceps, intend the Bu Banke Cordyceps, Cordyceps martialis Speg., the Lou Shan Cordyceps, Mus tail Cordyceps, green nuclear Cordyceps, the moorland Cordyceps, luxuriant blue Cordyceps, BUSHICHONGCAO, Cordyceps takaomontana, yellowish Cordyceps militaris (L.) Link., the bulb Cordyceps, the chafer Cordyceps, the Mantidis Cordyceps, the froghopper Cordyceps, handle shell Cordyceps, intend luxuriant blue Cordyceps, Cordyceps gracilioides, the hair Cordyceps, the wireworm Cordyceps, the Japan Cordyceps, the Xin Kelai Cordyceps, beak shell Cordyceps, intend dark green Cordyceps, high eyebrow Cordyceps, FENBEICHONGCAO, Dayi Cordyceps, the fork-tail Cordyceps, the Caulis cyatheae spinulosae Cordyceps, the Aeschna melanictera Cordyceps, the ant Cordyceps, the Luo Baici Cordyceps, Cordyceps kyushuensis, the buttress shaft Cordyceps, DAISHICHONGCAO, the distortion Cordyceps, rice mountain Cordyceps, two shuttle spore Cordycepses, Cordyceps gunnii (Berk.) Berk. etc.Worm powder after Cordyceps among the present invention comprises Cordyceps and grinds, refine the back Cordyceps extract through processing, or have a form in each growth course of Cordyceps.Cordyceps has the function that tonifying the lung kidney, cough-relieving are coughed, benefit is deficient, support vital essence.According to clinical research, Cordyceps has ten big functions and has foster lung yin, and kidney-replenishing, relieving cough and resolving phlegm, anticancer anti-old effect are the product of flat nourishing YIN sun, all nothings avoid that (men and women, old and young can both eat, be to be fit to the widest tonic of crowd, and do not need to avoid certain food that health is had tonification greatly, mend marrow lung benefiting kidney, and property of medicine gentleness, do not attend a meeting like the people that the people is produced is scorching, the benefit of Radix Ginseng is arranged and do not have the evil of Radix Ginseng).Can be used for the pulmonary tuberculosis hemoptysis, diseases such as impotence and seminal emission.
After the definition of " collaborative improve " can be understood as several medical materials combinations among the present invention, the raising of its drug effect during with respect to independent the use; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
In the component of the present invention, the flat sweet in the mouth of Cordyceps property has the function that kidney-replenishing, cough-relieving are coughed, benefit is deficient, support vital essence.The Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves, strong taste admittedly.The Stigma Croci sweet in the mouth is flat, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving, resisting fatigue.Be used for the treatment of troubled thoughts pent-up, the chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and is frightened fear in a trance, blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization and stomach invigorating soothing liver-QI.Spirulina has the opsonic immunity function, cholesterol reducing, promoting digestion, protecting liver, anticancer, antidotal effect.
The inventor finds by test, compositions of the present invention has remarkable role in synergy at the pathology that improves body immunity, resisting fatigue, have outside the effect that improves body immunity, resisting fatigue as compositions of the present invention, have the effect of improving male's sexual simultaneously.These single agent are that single agent is incomparable to the action effect of some function of human body after by a certain proportion of compositions.
Compositions of the present invention can directly be pulverized or through the active component of the refining compositions as treatment of the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation.Described active component can be made various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient composition, as is how granular tablet, granule, capsule, or oral liquid etc.According to using needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but not only be confined to following a kind of, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, the gained solution concentration is obtained extractum, then gained extractum be dissolved in 5-10 times of weight of extractum weight concentration in the ethanol water according to weight meter 95%, mix, quantitatively packing obtains oral liquid formulations.
The preparation method of tablet is that the active component mixture is sieved, and behind the auxiliary agent pulverizing commonly used with preparing tablet, abundant mix homogeneously, crosses the 40-80 eye mesh screen, by tabletting the direct machine of dry powder is pressed into tablet.
The preparation technology of capsule preparations can for, the active component mixture is sieved, pulverizing with the commonly used auxiliary agent of preparation tablet, fully behind the mix homogeneously, crossing the 40-80 eye mesh screen, by granulating, drying is irritated capsule after the operations such as granulate, polishing, packing gets product.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention has benefiting QI for strengthening the superficies, improve the immunity of organisms effect, medicine of the present invention is not warm not dry, have invigorating spleen and reinforcing stomach, improve microcirculation in human body, the effect of wet dissipation eliminating impediment, enhancing immunity, resisting fatigue, antiviral, strengthening body, evident in efficacy, action temperature and, have no side effect.This medicine production technology is simple, be easy to take, and is a kind of desirable raising human immunity, the medicine of resisting fatigue.
Detailed description of the preferred embodiments
Following examples have illustrated the each aspect of the present invention content.They only in order to explanation, not delimit the scope of the invention.
Embodiment 1: contain the capsule that the people participates in Stigma Croci, spirulina and Cordyceps
Radix Ginseng 65 grams, Stigma Croci 60 grams, spirulina 65 grams, Cordyceps 65 grams.
Above-mentioned Chinese medicine was soaked 40 minutes, it is important that the water surface is higher than raw material, add water total amount and be 8 times of total dose, the back little fire attitude of boiling of boiling is kept liquid level and is higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, 6 times the water that adds total dose again, the back little fire attitude of boiling of boiling is kept liquid level and is higher than raw material Chinese medicine height, decocted 2 hours, filter to merge twice filtrate, through concentrating under reduced pressure (pressure 0.06MPa, 65 ℃ of temperature) to dried cream, pulverize, through 300 mesh sieves, add the magnesium stearate of gross weight 2%, incapsulate and get final product.
Embodiment 2: contain the tablet that the people participates in Stigma Croci, spirulina and Cordyceps
Radix Ginseng 3 grams, Stigma Croci 2 grams, spirulina 4 grams, Cordyceps 4 grams.
Above-mentioned Chinese crude drug is dried and crushed into coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out behind the ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, mixing is granulated, and is pressed into tablet.
Embodiment 3: contain the capsule that the people participates in Stigma Croci, spirulina and Cordyceps militaris (L.) Link.
Radix Ginseng 20 grams, Stigma Croci 12 grams, spirulina 25 grams, Cordyceps militaris (L.) Link. 15 grams.
Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing is packed into firmly softgel shell, makes Chinese medicine composition of the present invention.
Embodiment 4: contain the oral liquid that the people participates in Stigma Croci, spirulina and Cordyceps
Radix Ginseng 50 grams, Stigma Croci 45 grams, spirulina 50 grams, Cordyceps 50 grams.
After the said components mixing, decoct with water, decoction liquor is filtered, obtain solution, the gained solution concentration is obtained extractum, gained extractum is dissolved in the concentration of 5-10 times of weight of extractum weight in the ethanol water according to weight meter 95% then, mix, quantitatively packing obtains oral liquid formulations.
Embodiment 5: contain the tablet that the people participates in Stigma Croci, spirulina and Cordyceps
Radix Ginseng 17 grams, Stigma Croci 13 grams, spirulina 45 grams, Cordyceps 12 grams
Above-mentioned Chinese crude drug is dried and crushed into coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out behind the ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, mixing is granulated, and is pressed into tablet.
Test example 1: the present invention tests effect of immunologic function
1, the product of testing product: embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 is sample.
2, animal is used in detection: mice, rat, male and female half and half.
3, test basis: Ministry of Public Health " health food check and assessment technique standard " (2003 editions)
4, test item:
4.1 body weight, thymus/body weight ratio, spleen/body weight ratio
4.2 the mouse spleen lymphocyte transformation experiment (mtt assay) that comA induces
4.3 the tardy paraphilia reaction of the mice that dinitrofluorobenzene is induced (DTH)
4.4 antibody-producting cell detects (Jerne improves slide method)
4.5 serum hemolysin test
4.6 mice carbon clearance test
4.7 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experiment (dripping the sheet method)
4.8 the NK cytoactive is measured
5, testing result and judgement
5.1 the body weight of laboratory animal, thymus/body weight ratio, the testing result of spleen/body weight ratio shows, under this experimental condition, institute's full pattern product 500,1000,3000mg during kg (be equivalent to respectively be grown up per kg body weight per day recommended intake 5 times, 10 times, 30 times) dosage, five groups of samples are to the body weight of animal, thymus/body weight ratio, and spleen/body weight ratio there is no obvious influence.
5.2 mouse spleen lymphocyte transformation experiment (mtt assay) result that comA induces shows that under this experiment condition, each dosage group optical density difference and solvent control class value relatively all do not have statistical significant difference (P＞0.05).The prompting sample does not have the mouse lymphocyte of enhancing multiplication capacity.
5.3 the tardy paraphilia reaction of the mice that dinitrofluorobenzene is induced is (DTH) result show, under this experiment condition, each dosage group optical density difference and solvent control class value relatively all do not have statistical significant difference (P＞0.05).The prompting sample has the tardy paraphilia reagentia of mice that the enhancing dinitrofluorobenzene causes.The test dose group is positive, and the prompting sample can strengthen the mouse cell immunologic function.
5.4 detecting (Jerne improves slide method) result, antibody-producting cell shows, under this experimental condition, each dosage group hemolysis plaque number average is higher than the solvent control class value, and low, middle dosage group has statistically-significant difference (P＜0.05), and the prompting sample has the ability that mice produces antibody producing cells that strengthens.
5.5 the serum hemolysin result of the test shows that under this experiment condition, each dosage group mice serum half hemolysis value and solvent control class value relatively all do not have statistically-significant difference (P＞0.05).The prompting sample does not have the ability that mice produces serum hemolysin that strengthens.The dosage group of a test is positive, and the prompting sample can strengthen the mouse humoral immune function.
5.6 the clearance test of mice carbon is the result show, under this experiment condition, each dosage group mice engulf tree planting A and solvent control class value relatively, all do not have statistical significant difference (P＞0.05).Prompting sample five strengthens the effect that carbon is cleaned up ability.
5.7 engulfing chicken red blood cell experiment (dripping the sheet method) result, Turnover of Mouse Peritoneal Macrophages shows, under this experimental condition, the monokaryon of each sample and each dosage group mice-macrophage phagocytic percentage rate and phagocytic index and solvent control class value relatively all do not have statistical significant difference (P＞0.05).Prompting sample five strengthens the effect of Turnover of Mouse Peritoneal Macrophages phagocytic activity.Result of the test is all negative, and the prompting sample does not have enhancing mouse monokaryon-macrophage phagocytic function.
5.8 NK cytoactive measurement result shows, under this experimental condition, the NK cytoactive of each dosage group mice all is higher than the solvent control class value, and high dose group has statistical significant difference (P＜0.05), the effect that the prompting sample has the NK cytoactive that strengthens mice.
Comprehensive above result of the test, according to health food enhancing immunity functional evaluation standard, 5 samples of prescription of the present invention all have the function of enhancing immunity.
Test example 2: the present invention is to improving the clinical efficacy of immune function of human body
The child: immunologic hypofunction, easy catching a cold, average every month more than twice, or suffer from twice above patient of pneumonia in 1 year.
Elderly patients: suffer from multiple chronic disease, be diagnosed as the patient of syndrome of deficiency of lung qi.
2, method of administration and the course for the treatment of:
The preparation of oral embodiment of the invention 1-4 embodiment.Contrast: Stigma Croci capsule, spirulina capsule, Radix Ginseng+spirulina (1: 1) capsule; Stigma Croci+Cordyceps (1: 1) capsule; Cordyceps+Radix Ginseng (1: 1) capsule.
Adult: each 3 examples, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, each 2-3 time.
Above patient was a course for the treatment of with one month all, and it treats 1-3 the course for the treatment of.
3, observational technique:
Carry out blood, urine, just routine test and the heart, pulmonary function test, and observe: heating, aversion to cold, sniffle, pharyngeal symptom and whole body situation and the temperature of having a medical check-up, pharyngeal tonsil, the picture of the tongue pulse condition, therapeutic evaluation is carried out in variations such as fingerprint respectively.
4, therapeutic evaluation
Table one prescription of the present invention improves the clinical observation of immune function of human body
Drug side effect of the present invention: period in a medicine small number of patients xerostomia, outside the dry stool, all there is not any untoward reaction, drug withdrawal or decrement, mouthfeel, dry stool transference cure.
Test example 3: the present invention is to the influence test of mouse anti-reflecting fatigue
Preparation of the present invention (embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5) is to mouse anti-reflecting fatigue influence test.90 of mices are divided into six groups at random, press the gastric infusion of dosage shown in the table 2, and every day 1 time, continuous 10 days, normal control group and model group gave the equal-volume distilled water, and volume is 20ml/kg.And in first day on-test.After the last administration 1 hour, animal is put into 15 ± 1 ℃ swimming groove, observe mice and put into water and be sink to the water-bed unable time of floating again for continuing swimming time.The results are shown in Table 2. by table 2 result as seen, compositions of the present invention can obviously prolong mice low temperature and continue swimming time.
Table 2. preparation of the present invention is to the influence of mice swimming time
Result of the test shows, but preparation significant prolongation mice low temperature of the present invention continues swimming time.Show that the present invention has the ability of resisting fatigue to mice.
Test example 4: the present invention is to impotence patient's clinical treatment
(1) clinical data
2009 are so far, and the preparation that the inventor utilizes embodiment 1, embodiment 2, embodiment 3 and embodiment 5 to make carries out clinical observation treatment to 544 routine impotence patients, wherein, and age 20-30 year, 108 examples; 31-40 year, 137 examples, 41-50 year, 133 examples, 51-60 year, 105 examples, more than 60 years old, 61 examples.Sexual impotence reason: sexual impotence 82 examples due to sexual impotence 68 examples due to psychic impotence 78 examples, nephropathy, hepatopathy, incretion sexual impotence 64 examples, sexual hypofunction (lowly) person 98 examples, psychogenic sexual impotence 56 examples, arteriosclerotic sexual impotence 21 examples, unknown cause sexual impotence 77 examples.Contrast medicament: the single agent capsules of Cordyceps, Cordyceps+spirulina capsule agent (1: 1).
(2) Therapeutic Method
Compositions of the present invention, warm water is for oral administration, and three times on the one, each 3-6g, one after each meal.Calculate treatment time according to the conditions of patients weight, patients with mild was taken 3 months, and the severe case serve on 6 months.
(3) curative effect determinate standard
Cure: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 80%.
Produce effects: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 50%.
Effectively: after the treatment phase, the erection situation makes moderate progress, and success rate of sexual intercourse is more than or equal to 30%.
Invalid: every index does not all have improvement before and after the medication.
(4) clinical effectiveness
Clinical trial shows, the present invention has excellent therapeutic effect to impotence patient, reaches more than 90% for patient's total effective rate of age less than 50 years old, along with the increase therapeutic effect at age also decreases, but still has curative effect preferably with comparing.
Claims (5)
1. one kind has the collaborative Halth-care composition that improves human body immunity of organisms, antifatigue effect and kidney invigorating and YANG supporting, it is characterized in that its effective ingredient is Radix Ginseng, Stigma Croci, spirulina and Cordyceps, and form according to the raw material of following weight parts: Radix Ginseng 4-50 part, Stigma Croci 3-45 part, spirulina 7-50 part, Cordyceps 8-45 part.
2. according to the compositions of claim 1, it is characterized in that described compositions is the preparation of peroral dosage form.
3. the compositions of claim 1 has the purposes that improves in the immunity health medicine in preparation.
4. the compositions of claim 1 has purposes in the anti-fatigue health-caring medicine in preparation.
5. the compositions of claim 1 has the health product for the treatment of sexual impotence or the purposes in the medicine in preparation.
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