CN102631496B - Traditional Chinese medicine composition capable of improving immunity and resisting fatigue - Google Patents
Traditional Chinese medicine composition capable of improving immunity and resisting fatigue Download PDFInfo
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Abstract
The invention relates to a health care product composition capable of improving the human body immunity and resisting fatigue. The composition comprises the active ingredients such as ginseng, crocus sativus, hippocampus japonicus and spirulina. The composition has the functions of enhancing the organism immunity, resisting fatigue, building bodies and relaxing tendons and activating collaterals and has obvious curative effect and mild effects.
Description
Technical field
The present invention relates to a kind of collaborative Chinese medicine composition that improves body immunity, resisting fatigue and relaxing muscles and tendons and activating QI and blood in the collateral function that has.
Technical background
Along with socioeconomic continuous development, the raising day by day of people's living standard, people increase gradually to the degree of keeping a grip on of health, live in now all be, we receive many outside threats easily at everyone health, comprise air pollution, video pollution, environmental pollution, operating pressure, economic pressures, bacterial virus, improper diet etc.Moreover, because the variation of city work, rhythm of life is easy to make the people to produce confirmed fatigue, i.e. sub-health state, the factor of all these unfavorable health can be made us spiritual usually and can not concentrate, hypomnesis, often indolent and listless, old and feeble ahead of time.Therefore improve autoimmunity, the ability that strengthens the various unfavorable health factors of antagonism is most important.
The health product that are used for enhancing human body immunity power on the market are of a great variety at present, but action effect is uneven.
Summary of the invention
The technical problem to be solved in the present invention is: the Chinese medicine composition that the purpose of this invention is to provide a kind of enhancing human body immunity power, resisting fatigue and relaxing muscles and tendons and activating QI and blood in the collateral function.By being main Chinese crude drug with Radix Ginseng, Stigma Croci, Hippocampus and spirulina, by mutual synergistic function, in the hope of improving resistance against diseases, enhance immunity effect, the engineering of alleviating physical fatigue and relaxing muscles and tendons and activating QI and blood in the collateral function.
For solving the problems of the technologies described above, the invention provides a kind of collaborative Halth-care composition that improves body immunity, resisting fatigue and relaxing muscles and tendons and activating QI and blood in the collateral that has, it is characterized in that described compositions comprises a kind of Halth-care composition that has Synergistic raising human body immunity of organisms, resisting fatigue and have the relaxing muscles and tendons and activating QI and blood in the collateral function of active component, is characterized in that described compositions comprises Radix Ginseng, Stigma Croci, Hippocampus, spirulina.In the active component by weight: Radix Ginseng 4-65 part, Stigma Croci 2-55 part, Hippocampus 5-60 part, spirulina 5-65 part.Preferably, Radix Ginseng 8-50 part, Stigma Croci 4-40 part, Hippocampus 7-45 part, spirulina 7-50 part.
Preferably, the weight proportion of each component is: 65 parts of Radix Ginsengs, 55 parts of Stigma Crocis, 60 parts of Hippocampus, 65 parts of spirulinas.
The weight proportion of preferred each component is: 4 parts of Radix Ginsengs, 2 parts of Stigma Crocis, 5 parts of Hippocampus, 5 parts of spirulinas.
The weight proportion of preferred each component is: 8 parts of Radix Ginsengs, 4 parts of Stigma Crocis, 7 parts of Hippocampus, 7 parts of spirulinas.
Preferably, the weight proportion of each component is: 50 parts of Radix Ginsengs, 40 parts of Stigma Crocis, 45 parts of Hippocampus, 50 parts of spirulinas.
Medicinal and the health properties of each component that the present invention adopts is:
Radix Ginseng: related Radix Ginseng refers to the general name of a kind of herbaceos perennial of the Umbellales Araliaceae Radix Ginseng Panax of family among the present invention, comprises Radix Ginseng Rubra, Radix Ginseng, Radix Panacis Quinquefolii (Radix Panacis Quinquefolii), Radix Glehniae, Radix Codonopsis and Radix Pseudostellariae etc.Radix Ginseng among the present invention comprises through processing and refines back Radix Ginseng extract, various forms in grinding descendant's pure extract powder or Radix Ginseng growth course.Have sweet little hardship, warm in nature, go into spleen, lung meridian, strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves.It is deficient to control impairment caused by overstrain, lack of appetite, and asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the disease of all qi-blood-body fluid deficiencies.
Stigma Croci: involved in the present invention to Stigma Croci (claiming Stigma Croci, Stigma Croci again), be the perennial flowers of a kind of Liliales Iridaceae crocus.Stigma Croci among the present invention comprises crocein powder after grinding, obtains Stigma Croci extracts or croceous other processing forms by various processes.Stigma Croci is used for the treatment of the multiple chronic disease of human body clinically, by the effect of its blood circulation promoting and blood stasis dispelling, anti-inflammation, and enhancing body endurance, strengthen lymphproliferation response, improve body cell immunity and humoral immunization with this, play human functional activity of vital energy operation, the effect of balance human body negative and positive adjusted.
Hippocampus: belong to net-rope, the Solenognathus order, the general name of Hippocampus animal belongs to bony fish.Hippocampus is the higher rare Chinese medicine of a kind of economic worth, contains aminoacid and protein, fatty acid, steroidal and inorganic elements.Its property is sweet, warm, go into liver, kidney channel, kidney invigorating and YANG supporting, regulating qi and activating blood is controlled sexual impotence, the enuresis, dyspnea due to deficiency, difficult labour, furuncle swelling toxin, and have medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma, particularly more effective for the neural disease for the treatment of.
Spirulina: belong to the class rudimentary plant in Cyanophyta, Cyanophyceae, hormocystangium order, Oscillariaceae, the Spirullina, mainly comprise spirulina maxim, spirulina plalensis.Spirulina among the present invention comprises other processing forms of refining rear screw algae extract or spirulina through processing.Bitter salty, cold, go into spleen, lung, kidney channel, antibiotic, radioprotective, cholesterol reducing, enhancing immunity.
After the definition of " collaborative improve " can be understood as several medical materials combinations among the present invention, the raising of its drug effect during with respect to independent the use; Drug effect is more lasting; Compositions produces beyond thought effect in new control or healthcare field.
In the component of the present invention, Radix Ginseng strongly invigorating primordial QI, impairment caused by overstrain are deficient, the Fructus Alpiniae Oxyphyllae of calming the nerves.The Stigma Croci sweet in the mouth is flat, dispersing stagnation and relieving accumulation of pathogens, resisting fatigue, resolving stagnation for tranquilization.Hippocampus has building body, improves immune function, relaxing muscles and tendons and activating QI and blood in the collateral, tranquillizing and allaying excitement function.Spirulina has the enhancing human body immunity function, improves effectiveness.
The inventor finds by test, compositions of the present invention has remarkable role in synergy at the pathology that improves body immunity, resisting fatigue, have outside the effect that improves body immunity, resisting fatigue as compositions of the present invention, have the effect of relaxing muscles and tendons and activating QI and blood in the collateral simultaneously.Compositions of the present invention is that single agent is incomparable to the beneficial effect effect of some function of human body.
Compositions of the present invention can directly be pulverized or through the active component of the refining compositions as treatment of the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation.Described active component can be made various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient composition, as is how granular tablet, granule, capsule, or oral liquid etc.According to using needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The preparation method of oral liquid, can but not only be confined to following a kind of, after active component is mixed, decoct with water, decoction liquor is filtered, obtain solution, the gained solution concentration is obtained extractum, then gained extractum be dissolved in 5-10 times of weight of extractum weight concentration in the ethanol water according to weight meter 95%, mix, quantitatively packing obtains oral liquid formulations.
The preparation method of tablet is that the active component mixture is sieved, and behind the auxiliary agent pulverizing commonly used with preparing tablet, abundant mix homogeneously, crosses the 40-80 eye mesh screen, by tabletting the direct machine of dry powder is pressed into tablet.
The preparation technology of capsule preparations can for, the active component mixture is sieved, pulverizing with the commonly used auxiliary agent of preparation tablet, fully behind the mix homogeneously, crossing the 40-80 eye mesh screen, by granulating, drying is irritated capsule after the operations such as granulate, polishing, packing gets product.
The invention has the beneficial effects as follows:
Pharmaceutical composition of the present invention has benefiting QI for strengthening the superficies, improves the immunity of organisms effect, and medicine of the present invention is not warm not dry, effect with invigorating spleen and reinforcing stomach, relaxing muscles and tendons and activating QI and blood in the collateral, wet dissipation eliminating impediment, enhancing immunity, resisting fatigue, antiviral, strengthening body, evident in efficacy, action temperature and, have no side effect.This medicine production technology is simple, be easy to take, and is a kind of desirable raising human immunity, the medicine of resisting fatigue.
Detailed description of the preferred embodiments
Following examples have illustrated the each aspect of the present invention content.They only in order to explanation, not delimit the scope of the invention.
Embodiment 1: contain the capsule that the people participates in Stigma Croci, Hippocampus and spirulina glycosides
Radix Ginseng 65 grams, Stigma Croci 55 grams, Hippocampus 60 grams, spirulina 65 grams.
Above-mentioned Chinese medicine was soaked 40 minutes, it is important that the water surface is higher than raw material, add water total amount and be 8 times of total dose, the back little fire attitude of boiling of boiling is kept liquid level and is higher than raw material Chinese medicine height, decocts 2 hours, cross leaching filtrate, 6 times the water that adds total dose again, the back little fire attitude of boiling of boiling is kept liquid level and is higher than raw material Chinese medicine height, decocted 2 hours, filter to merge twice filtrate, through concentrating under reduced pressure (pressure 0.06MPa, 65 ℃ of temperature) to dried cream, pulverize, through 300 mesh sieves, add the magnesium stearate of gross weight 2%, incapsulate and get final product.
Embodiment 2: contain the tablet that the people participates in Stigma Croci, Hippocampus and spirulina
Radix Ginseng 4 grams, Stigma Croci 2 grams, Hippocampus 5 grams, spirulina 5 grams.
Above-mentioned Chinese crude drug is dried and crushed into coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out behind the ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, mixing is granulated, and is pressed into tablet.
Embodiment 3: contain the capsule that the people participates in Stigma Croci, Hippocampus and spirulina glycosides
Radix Ginseng 8 grams, Stigma Croci 4 grams, Hippocampus 7 grams, spirulina 7 grams.
Above-mentioned Chinese crude drug is dried and crushed into fine powder, sieves, mixing is packed into firmly softgel shell, makes Chinese medicine composition of the present invention.
Embodiment 4: contain the oral liquid that the people participates in Stigma Croci, Hippocampus and spirulina glycosides
Radix Ginseng 50 grams, Stigma Croci 40 grams, Hippocampus 45 grams, spirulina 50 grams.
After the said components mixing, decoct with water, decoction liquor is filtered, obtain solution, the gained solution concentration is obtained extractum, gained extractum is dissolved in the concentration of 5-10 times of weight of extractum weight in the ethanol water according to weight meter 95% then, mix, quantitatively packing obtains oral liquid formulations.
Embodiment 5: contain the tablet that the people participates in Stigma Croci, Hippocampus and spirulina
Radix Ginseng 18 grams, Stigma Croci 10 grams, Hippocampus 25 grams, spirulina 20 grams
Above-mentioned Chinese crude drug is dried and crushed into coarse powder, with the ethanol of 50-60% be solvent 60-70 ℃ of reflux, extract,, extracting solution is being gone out behind the ethanol, cryoconcentration becomes thick extractum, drying is ground into fine powder, sieves, mixing is granulated, and is pressed into tablet.
Test example 1: the present invention tests effect of immunologic function
1, the product of testing product: embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 is sample.
2, animal is used in detection: mice, rat, male and female half and half.
3, test basis: Ministry of Public Health " health food check and assessment technique standard " (2003 editions)
4, test item:
4.1 body weight, thymus/body weight ratio, spleen/body weight ratio
4.2comA the mouse spleen lymphocyte transformation experiment (mtt assay) of inducing
4.3 the tardy paraphilia reaction of the mice that dinitrofluorobenzene is induced (DTH)
4.4 antibody-producting cell detects (Jerne improves slide method)
4.5 serum hemolysin test
4.6 mice carbon clearance test
4.7 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experiment (dripping the sheet method)
4.8NK cytoactive is measured
5, testing result and judgement
5.1 the body weight of laboratory animal, thymus/body weight ratio, the testing result of spleen/body weight ratio shows, under this experimental condition, institute's full pattern product 500,1000,3000mg during kg (be equivalent to respectively be grown up per kg body weight per day recommended intake 5 times, 10 times, 30 times) dosage, five groups of samples are to the body weight of animal, thymus/body weight ratio, and spleen/body weight ratio there is no obvious influence.
5.2comA mouse spleen lymphocyte transformation experiment (mtt assay) result who induces shows that under this experiment condition, each dosage group optical density difference and solvent control class value relatively all do not have statistical significant difference (P＞0.05).The prompting sample does not have the mouse lymphocyte of enhancing multiplication capacity.
5.3 the tardy paraphilia reaction of the mice that dinitrofluorobenzene is induced is (DTH) result show, under this experiment condition, each dosage group optical density difference and solvent control class value relatively all do not have statistical significant difference (P＞0.05).The prompting sample has the tardy paraphilia reagentia of mice that the enhancing dinitrofluorobenzene causes.The test dose group is positive, and the prompting sample can strengthen the mouse cell immunologic function.
5.4 detecting (Jerne improves slide method) result, antibody-producting cell shows, under this experimental condition, each dosage group hemolysis plaque number average is higher than the solvent control class value, and low, middle dosage group has statistically-significant difference (P＜0.05), and the prompting sample has the ability that mice produces antibody producing cells that strengthens.
5.5 the serum hemolysin result of the test shows that under this experiment condition, each dosage group mice serum half hemolysis value and solvent control class value relatively all do not have statistically-significant difference (P＞0.05).The prompting sample does not have the ability that mice produces serum hemolysin that strengthens.The dosage group of a test is positive, and the prompting sample can strengthen the mouse humoral immune function.
5.6 the clearance test of mice carbon is the result show, under this experiment condition, each dosage group mice engulf tree planting A and solvent control class value relatively, all do not have statistical significant difference (P＞0.05).Prompting sample five strengthens the effect that carbon is cleaned up ability.
5.7 engulfing chicken red blood cell experiment (dripping the sheet method) result, Turnover of Mouse Peritoneal Macrophages shows, under this experimental condition, the monokaryon of each sample and each dosage group mice-macrophage phagocytic percentage rate and phagocytic index and solvent control class value relatively all do not have statistical significant difference (P＞0.05).Prompting sample five strengthens the effect of Turnover of Mouse Peritoneal Macrophages phagocytic activity.Result of the test is all negative, and the prompting sample does not have enhancing mouse monokaryon-macrophage phagocytic function.
5.8NK the cytoactive measurement result shows, under this experimental condition, the NK cytoactive of each dosage group mice all is higher than the solvent control class value, and high dose group has statistical significant difference (P＜0.05), the effect that the prompting sample has the NK cytoactive that strengthens mice.
Comprehensive above result of the test, according to health food enhancing immunity functional evaluation standard, 5 samples of prescription of the present invention all have the function of enhancing immunity.
Test example 2: the present invention is to improving the clinical efficacy of immune function of human body
The child: immunologic hypofunction, easy catching a cold, average every month more than twice, or suffer from twice above patient of pneumonia in 1 year.
Elderly patients: suffer from multiple chronic disease, be diagnosed as the patient of syndrome of deficiency of lung qi.
2, method of administration and the course for the treatment of:
The preparation of oral embodiment of the invention 1-5 embodiment.Contrast: Stigma Croci list agent capsules, spirulina list agent capsules
Adult: each 3 examples, every day 3 times.
Child below 6 years old: each 1, every day 2-3 time.
Child more than 6 years old: each 2, each 2-3 time.
Above patient was a course for the treatment of with one month all, and it treats 1-3 the course for the treatment of.
3, observational technique:
Carry out blood, urine, just routine test and the heart, pulmonary function test, and observe: heating, aversion to cold, sniffle, pharyngeal symptom and whole body situation and the temperature of having a medical check-up, pharyngeal tonsil, the picture of the tongue pulse condition, therapeutic evaluation is carried out in variations such as fingerprint respectively.
4, therapeutic evaluation
Table one prescription of the present invention improves the clinical observation of immune function of human body
Drug side effect of the present invention: period in a medicine small number of patients xerostomia, outside the dry stool, all there is not any untoward reaction, drug withdrawal or decrement, mouthfeel, dry stool transference cure.
Test example 3: the present invention is to the influence test of mouse anti-reflecting fatigue
Preparation of the present invention (embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5) influences test through disease prevention and control center, Jiangsu Province to mouse anti-reflecting fatigue.90 of mices are divided into six groups at random, press the gastric infusion of dosage shown in the table 2, and every day 1 time, continuous 10 days, normal control group and model group gave the equal-volume distilled water, and volume is 20ml/kg.And in first day on-test.After the last administration 1 hour, animal is put into 15 ± 1 ℃ swimming groove, observe mice and put into water and be sink to the water-bed unable time of floating again for continuing swimming time.The results are shown in Table 2. by table 2 result as seen, compositions of the present invention can obviously prolong mice low temperature and continue swimming time.
Table 2. preparation of the present invention is to the influence of mice swimming time
Result of the test shows, but preparation significant prolongation mice low temperature of the present invention continues swimming time.Show that the present invention has the ability of resisting fatigue to mice.
Test example 4: the present invention is used for the clinical treatment test of relaxing muscles and tendons and activating QI and blood in the collateral
The present invention is used for the indication of relaxing muscles and tendons and activating QI and blood in the collateral: take when grain, fascia, muscle tendon, bone injury, lumbago and skelalgia etc., dislocation reset conditioning.Absorb the focus that is penetrated into body local organs, tissue by digestive system, produce pharmacodynamics effect, reach that blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, Shujin are regulated the flow of vital energy, the effect of reunion of fractured tendons and bones, thereby treatment there is better curative effect to focuses such as grain, fascia, muscle tendon, bone injury, lumbago and skelalgia; Utilize the embodiment of the invention 1 and implement 2 medicaments that make, through clinical use 158 examples, cervical spondylosis 45 examples wherein, 41 examples of fracturing, 72 examples are sprained in motion, all obtain good result, and effective percentage is 92.7%, is 77.5% well, and the patient all has no adverse reaction.Specifically be exemplified below:
1, Mrs Xiong, 45 years old, by the bicycle right thigh hip of wounding, the X ray examination, right intertrochanteric fracture of the femur, fascia come off, the inside retrodisplacement of its far-end, local swelling is serious.With the preparation for treating of embodiment 1 after 3 courses for the treatment of, the patient can hold up and turning the exercise of leaving the bed and walk, and 2 first quarter moons are through the existing a large amount of callus formation of X ray examination, and patient can lose and abduct the road.2 years no sequels of follow-up observation.
2, Mr. Wu, 37 years old, giddy uncomfortable in chest, rapid breathing is diagnosed as cervical vertebra 3-6 hyperosteogeny, neck 3-4 intervertebral disk hernia through cervical vertebra CT.Symptom obviously alleviates after using a course for the treatment of with the preparation of embodiment 3, takes after 2 months and alleviates, and continuous clothes are after 1 month, and condition of illness disappears, so far recurrence.
3, Miss Liu, 27 years old, to wipe window and throw from balcony, disease is that arm fracture, grain are hindered, patient's left arm is stiff.With reset back and use plaster fixation of sclerite, with preparation every day of embodiment 2 sooner or later twice, adhere to that the patient stops treatment after 1 month, carry out functional exercise, left arm heals after 2 months.
4, Mr. Wu, 19 years old, collided by the classmate when playing basketball, sprain of knee joint, two knee joint pain, swelling with the prescription preparation of embodiment 4 all transference cures after 3 courses for the treatment of, are followed up a case by regular visits to and were not seen recurrence in 1 year half.
Claims (5)
1. one kind has the collaborative Halth-care composition that improves human body immunity of organisms, antifatigue effect and relaxing muscles and tendons and activating QI and blood in the collateral, it is characterized in that its effective ingredient is Radix Ginseng, Stigma Croci, Hippocampus and spirulina, and form according to the raw material of following weight parts: Radix Ginseng 8-50 part, Stigma Croci 4-40 part, Hippocampus 7-45 part, spirulina 7-50 part.
2. according to the compositions of claim 1, it is characterized in that described compositions is the preparation of peroral dosage form.
3. the compositions of claim 1 has the purposes that improves in the immunity health medicine in preparation.
4. the compositions of claim 1 has purposes in the anti-fatigue health-caring medicine in preparation.
5. the compositions of claim 1 has purposes in the relaxing muscles and tendons and activating QI and blood in the collateral functional health medicine in preparation.
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Effective date of registration: 20220916 Address after: 224100 6, Jinfeng South Street, Dafeng District, Yancheng City, Jiangsu. Patentee after: Dafeng District Productivity Promotion Center, Yancheng City Address before: Ji Hongjinzhuan, Development Department, Jiangsu Huifeng Agrochemical Co., Ltd., South Head of Wanggang Zha, Dafeng City, Yancheng City, Jiangsu Province, 224100 Patentee before: Yang Cuihong |
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