CN105477384A - Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition - Google Patents
Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition Download PDFInfo
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- CN105477384A CN105477384A CN201610024719.8A CN201610024719A CN105477384A CN 105477384 A CN105477384 A CN 105477384A CN 201610024719 A CN201610024719 A CN 201610024719A CN 105477384 A CN105477384 A CN 105477384A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses traditional Chinese medicine composition capable of reducing blood pressure. The composition comprises tall gastrodia tubers, tortoise shells, dogbane leaves, lotus plumule, honeysuckle flowers, motherwort fruits, gambir plant, herba of manchurian wildginger, cassia seeds, fluorite and milkvetch roots. The invention further discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the advantages of good curative effect, low cost, high cure rate, capability of avoiding adverse effects and the like in reducing blood pressure. The traditional Chinese medicine composition can calm the liver, suppress yang, remove blood stasis, invigorate blood circulation and reduce the cardiovascular accident incidence and death rate to the maximum, is convenient and easy to prepare, has small toxic and side effects, has a good blood pressure reducing effect and can be applied to clinical practice in quantities, raw materials are cheap, and the preparation method is simple.
Description
Technical field
The present invention relates to a kind of medicinal preparation, particularly relate to a kind of Chinese medicine composition for reducing blood pressure and preparation method thereof.
Background technology
The blood pressure of normal person fluctuates within the specific limits with internal and external environment change.Overall crowd, blood pressure level raised gradually with the age, more obvious with systolic pressure, but after 50 years old, diastolic pressure presents downward trend, and pulse pressure also strengthens thereupon.In recent years; the understanding of people to the effect of cardiovascular diseases's multiple risk factors and the heart, brain, kidney target-organ protection deepens continuously; hypertensive diagnostic criteria is also in continuous adjustment; think that the danger difference of cardiovascular diseases occurs the patient of same blood pressure level at present; therefore the concept of blood pressure layering has been had; namely the different patient of cardiovascular diseases's risk factor occurs, and suitable blood pressure level should have difference.Doctor on the basis of reference standard, judges the most suitable blood pressure range of this patient according to its concrete condition, adopts remedy measures targetedly when patient.
Hypertensive symptom varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, blood pressure only can occur after fatigue, psychentonia, anxious state of mind and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Now be called as benign hypertension.Benign hypertension common clinical symptoms has headache, dizziness, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.Even there will be severe headache, vomiting, cardiopalmus, the symptom such as dizzy when blood pressure is elevated to a certain degree suddenly, time serious, obnubilation, tic can occur.This just belongs to accelerated hypertension and hypertension critical illness, how infringement and the pathological changes of the organs such as the serious heart, brain, kidney can occur in a short time, as apoplexy, heart infarction, renal failure etc.Symptom there is no consistent relation with the level that blood pressure raises.
At present, the rejuvenation of hypertensive age of onset trend threatens human life and the great illness of quality of life.At present, clinically to take western medicine, suitably give depressor, majority need to take medicine throughout one's life, and the time has been grown Liver and kidney function infringement increasing.Use Chinese medicine hypertension that toxic and side effects is greatly reduced, the Chinese medicine of current state's internal therapy hypertension aspect is also a lot, but existing Chinese medicine formula effect is not very good.
Therefore, needing badly provides a kind of and in reducing blood pressure, has the advantages such as good effect, cost is low, cure rate is high, have no adverse reaction and can suppressing the hyperactive liver and subsiding YANG, promoting blood circulation by removing blood stasis, can reduce the unexpected incidence rate of cardiovascular and cerebrovascular vessel and mortality rate to greatest extent, and processing technology is easy, toxic and side effects is little, be easy to manufacture and the Chinese medicine composition that raw material is cheap, preparation method simply reduces blood pressure.
Summary of the invention
In order to solve the problem, the invention provides and a kind of there is the advantages such as good effect, cost is low, cure rate is high, have no adverse reaction in reducing blood pressure and can suppressing the hyperactive liver and subsiding YANG, promoting blood circulation by removing blood stasis, can reduce the unexpected incidence rate of cardiovascular and cerebrovascular vessel and mortality rate to greatest extent, and processing technology is easy, toxic and side effects is little, be easy to manufacture and the Chinese medicine composition that raw material is cheap, preparation method simply reduces blood pressure.
The technical solution used in the present invention is: a kind of Chinese medicine composition reduced blood pressure, and each component of described Chinese medicine composition is Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti, Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis, large Herba Swertiae heteranthae, Semen Cassiae, Fluoritum, the Radix Astragali.
Preferably, the ratio of weight and number of various component is Rhizoma Gastrodiae 25-35 part, Carapax Et Plastrum Testudinis 15-25 part, Folium Apocyni Veneti 15-25 part, Plumula Nelumbinis 10-20 part, Flos Lonicerae 10-20 part, Fructus Leonuri 5-15 part, Ramulus Uncariae Cum Uncis 5-15 part, large Herba Swertiae heteranthae 5-15 part, Semen Cassiae 5-15 part, Fluoritum 5-15 part, Radix Astragali 5-15 part.
Preferred, the ratio of weight and number of various component is Rhizoma Gastrodiae 30-35 part, Carapax Et Plastrum Testudinis 20-25 part, Folium Apocyni Veneti 20-25 part, Plumula Nelumbinis 10-15 part, Flos Lonicerae 10-15 part, Fructus Leonuri 5-10 part, Ramulus Uncariae Cum Uncis 5-10 part, large Herba Swertiae heteranthae 5-10 part, Semen Cassiae 5-10 part, Fluoritum 5-10 part, Radix Astragali 5-10 part.
Wherein, the dosage form of described Chinese medicine composition is: film coated tablet, sublimed preparation, plaster, syrup, oral liquid, suck agent, granule, powder, injection, sugar coated tablet, capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine is capsule, comprising:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine is injection, comprising:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
Rhizoma Gastrodiae nature and flavor are sweet flat, nontoxic, think that it enters spleen, kidney, liver, gallbladder, heart channel in " book on Chinese herbal medicine is newly organized ", energy endogenous wind stopping, arresting convulsion, controls dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom, " Japan hanako materia medica " thinks its aid yang qi, mends five kinds of strain and seven kinds of impairment, promoting blood circulation, has one's ideas straightened out.
Carapax Et Plastrum Testudinis salty in the mouth, sweet, cold nature, nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood, Gu through only collapsing, have nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood, Gu the effect through only collapsing.Be usually used in deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful, and metrorrhagia is through many.
Folium Apocyni Veneti, nature and flavor are sweet, cool, bitter, return Liver Channel, can calm the nerves by suppressing the hyperactive liver, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.
Plumula Nelumbinis nature and flavor are bitter, cold in nature, GUIXIN, kidney channel, clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.For heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood is spitted blood.
Fructus Leonuri nature and flavor are pungent, bitter, be slightly cold, and GUIXIN bag, Liver Channel, have promoting blood flow to regulate menstruation, effect of liver heat removing and eyesight improving.For menoxenia, amenorrhea dysmenorrhea, cataract, dizzy distending pain.
Ramulus Uncariae Cum Uncis, thinks in " book on Chinese herbal medicine is newly organized " and goes wind very fast by its Ramulus Uncariae Cum Uncis, have wind disease person to use it.But the life of wind-fire, many because of in deficiency of kidney-YIN, so that wooden dryness-fire is scorching, in YIN-tonifying drug, use Ramulus Uncariae Cum Uncis less, then wind-fire is fugitive, if complete not nourishing YIN, pure Ramulus Uncariae Cum Uncis is loose fiery to dispel the wind, then wind can not cease, and fiery and more vehement.Ramulus Uncariae Cum Uncis is used as medicine with the stem branch of buckle, and it has heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion effect, and modern pharmacology experiment also proves that Ramulus Uncariae Cum Uncis has hypotensive effect, therefore has very high medical value.
Flos Lonicerae sweet in the mouth, cold in nature, return lung, the heart, stomach warp, heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Large Herba Swertiae heteranthae nature and flavor are pungent, warm, warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.Main cough due to wind and cold; Rheumatic arthralgia; Stomachache; Stomachache; Toothache.
Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat.
Fluoritum nature and flavor are sweet, warm, GUIXIN, lung, kidney channel, energy tranquilizing mind, warming the lung, warm palace.For insomnia and dreamful sleep, palpitation and being susceptible to fright, cough and asthma due to lung deficiency, infertility.
Radix Astragali sweet in the mouth, warm in nature, return lung, spleen channel, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Beneficial effect of the present invention:
Relative to the medicine with the effect that reduces blood pressure of the prior art, adopt traditional Chinese medicine composition of the present invention in reducing blood pressure, have the advantages such as good effect, cost is low, cure rate is high, have no adverse reaction.The present invention can suppressing the hyperactive liver and subsiding YANG, promoting blood circulation by removing blood stasis, the unexpected incidence rate of cardiovascular and cerebrovascular vessel and mortality rate can be reduced to greatest extent, and processing technology is easy, toxic and side effects is little, be easy to manufacture and raw material is cheap, preparation method is simple, there is the effect that well reduces blood pressure, the present invention in clinical practice can be applied in a large number easy to use, and cheap, easy to use, can good social value and economic interests be created.
Detailed description of the invention
Embodiment 1:
(1) Chinese medicine reduced blood pressure, is formed by following raw material medicaments in part by weight proportioning:
30 parts, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis 25 parts, Folium Apocyni Veneti 20 parts, Plumula Nelumbinis 15 parts, Flos Lonicerae 15 parts, Fructus Leonuri 10 parts, Ramulus Uncariae Cum Uncis 10 parts, large Herba Swertiae heteranthae 10 parts, Semen Cassiae 10 parts, Fluoritum 5 parts, the Radix Astragali 5 parts.
(2) preparation method:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
Embodiment 2:
(1) Chinese medicine reduced blood pressure, is formed by following raw material medicaments in part by weight proportioning: with embodiment 1.
(2) preparation method:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
Embodiment 3:
1, long term toxicity test process:
Experimental agents is set as high, medium and low three dosage by application Wistar rat (Beijing Vital River Experimental Animals Technology Co., Ltd. provides), is respectively capsule 8g/kg, 4g/kg, 2g/kg of embodiment 1 formula.Calculating with dosage 0.1g/kg/ sky-backing by people, is 80 times of people's effective dose, 40 times and 20 times respectively; Separately establish a matched group, continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal, after 10 days, observe the impact on the every physiology of rat, biochemical indicator.Experimental result shows: by various dose to rat continuous oral 180 days, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.
2, acute toxicity test process:
Application ICR mice (Beijing Vital River Experimental Animals Technology Co., Ltd. provides) 40, body weight, at 25-30 gram, carries out acute toxicity testing.Mice is divided into two groups at random, i.e. matched group, administration group, fasting 12 hours before experiment, then Chinese medicine capsules suspension of the present invention (be dissolved in water by capsule and the obtain suspension) gavage as embodiment 1 prepares is given, test determination is carried out to the median lethal dose(LD 50) (LD50) of administration, but has not measured LD
50, because this has been mtd test.Result: with Cmax (60%), maximum dosage-feeding (120ml/kg, in one day, part gives for four times) 100g/kg gavage, be equivalent to crude drug amount 60g/kg, be equivalent to be grown up 300 times (by 75kg) of the daily dosage of clinical plan, none death of mice in seven days, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice are without any difference.
Embodiment 4:
Clinical treatment observation of the present invention is as follows:
(1) patient 150 example, wherein male 100 example, women 50 example.
(2) diagnostic criteria:
TCM syndrome diagnostic criteria reference Ministry of Public Health " new Chinese medicine Hypertension guideline of clinical investigations ", " the hypertension prevention and control guide " of Evaluation of Diagnostic Criteria of Hypertension reference World Health Organization (WHO) and Chinese hypertension Leagues enact.
(3) Therapeutic Method: 1 group: adopt capsule 100g as obtained in embodiment 1 preparation method, be divided into 10 parts, every morning, (medicine) being taken before meal was a, within 30 days, was a course for the treatment of, took two courses for the treatment of continuously; 2 groups: adopt injection 100g as obtained in embodiment 2 preparation method, be divided into 10 parts, every morning injects portion on an empty stomach, within 30 days, is a course for the treatment of, injects two courses for the treatment of continuously; Separately establish a matched group.
(4) efficacy assessment standard:
Criterion of therapeutical effect: with reference to the efficacy of antihypertensive treatment standard formulated in Ministry of Public Health " guideline of clinical investigations of new Chinese medicine Hypertension ".
Effective: (1) diastole pressure drop is low≤1.3kPa, and reach normal range; (2) though diastolic pressure does not drop to normally, Xiaed Jiang≤2.7kPa, wherein 1 must have been possessed.
Take a turn for the better: (1) diastolic pressure decline <1.3kPa, but reach normal range; (2) diastolic pressure comparatively treats front decline 1.3-2.5kPa, but does not reach normal range; (3) systolic pressure comparatively treats front decline≤4.0kPa, must possess wherein 1.
Invalid: not reach above-mentioned standard.
(5) therapeutic outcome is in table 1:
Table 1 therapeutic outcome
| Group | Effectively | Take a turn for the better | Invalid |
| Matched group | 0 | 15 | 35 |
| 1 group | 45 | 3 | 2 |
| 2 groups | 47 | 2 | 1 |
Above-described embodiment, just in order to technical conceive of the present invention and feature are described, its objective is and is one of ordinary skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The change of every equivalence done by the essence of content of the present invention or modification, all should be encompassed in protection scope of the present invention.
Claims (6)
1. the Chinese medicine composition reduced blood pressure, is characterized in that: each component of described Chinese medicine composition is Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti, Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis, large Herba Swertiae heteranthae, Semen Cassiae, Fluoritum, the Radix Astragali.。
2. Chinese medicine composition as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Rhizoma Gastrodiae 25-35 part, Carapax Et Plastrum Testudinis 15-25 part, Folium Apocyni Veneti 15-25 part, Plumula Nelumbinis 10-20 part, Flos Lonicerae 10-20 part, Fructus Leonuri 5-15 part, Ramulus Uncariae Cum Uncis 5-15 part, large Herba Swertiae heteranthae 5-15 part, Semen Cassiae 5-15 part, Fluoritum 5-15 part, Radix Astragali 5-15 part.
3. Chinese medicine composition as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Rhizoma Gastrodiae 30-35 part, Carapax Et Plastrum Testudinis 20-25 part, Folium Apocyni Veneti 20-25 part, Plumula Nelumbinis 10-15 part, Flos Lonicerae 10-15 part, Fructus Leonuri 5-10 part, Ramulus Uncariae Cum Uncis 5-10 part, large Herba Swertiae heteranthae 5-10 part, Semen Cassiae 5-10 part, Fluoritum 5-10 part, Radix Astragali 5-10 part.
4. the Chinese medicine composition reduced blood pressure according to any one of claim 1-3, it is characterized in that, the dosage form of described Chinese medicine composition is: film coated tablet, sublimed preparation, plaster, syrup, oral liquid, suck agent, granule, powder, injection, sugar coated tablet, capsule.
5. a preparation method for the Chinese medicine composition reduced blood pressure according to any one of claim 1-3, is characterized in that: when the dosage form of described Chinese medicine is capsule, comprising:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
6. a preparation method for the Chinese medicine composition reduced blood pressure according to any one of claim 1-3, is characterized in that: when the dosage form of described Chinese medicine is injection, comprising:
The first step, Rhizoma Gastrodiae, Carapax Et Plastrum Testudinis, Folium Apocyni Veneti are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Plumula Nelumbinis, Flos Lonicerae, Fructus Leonuri, Ramulus Uncariae Cum Uncis determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
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Application publication date: 20160413 |