CN106177326A - A kind of Chinese medicine composition treating nephropathy and preparation method thereof - Google Patents

A kind of Chinese medicine composition treating nephropathy and preparation method thereof Download PDF

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CN106177326A
CN106177326A CN201610649186.2A CN201610649186A CN106177326A CN 106177326 A CN106177326 A CN 106177326A CN 201610649186 A CN201610649186 A CN 201610649186A CN 106177326 A CN106177326 A CN 106177326A
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parts
radix
chinese medicine
medicine composition
nephropathy
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刘昊
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Beijing Zhicheng Biomedical Technology Co Ltd
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Beijing Zhicheng Biomedical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/44Ebenaceae (Ebony family), e.g. persimmon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of Chinese medicine composition treating nephropathy, described Chinese medicine composition is made up of the raw material of following weight portion: Folium Kaki 25 35 parts, Radix Rehmanniae Preparata 10 16 parts, Radix Rehmanniae 9 15 parts, Ramulus Cinnamomi 5 10 parts, the Radix Astragali 5 15 parts, the Radix Angelicae Dahuricae 11 16 parts, Hedyotidis Diffusae 11 15 parts, Semen Plantaginis 10 12 parts, Radix Angelicae Sinensis 69 parts, Radix Morindae Officinalis 8 10 parts, Colla cornus cervi 58 parts, Rhizoma Dioscoreae 8 12 parts, Fructus Lycii 8 15 parts, Semen Cuscutae 69 parts, 10 16 parts of Radix Glycyrrhizae.Chinese medicine composition disclosed by the invention, each component all uses natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, low cost.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug use the use that is decocted in water for oral dose.Verify by clinic application, treatment nephropathy evident in efficacy reliably, mild in medicine property and, do not occur that toxic and side effects, effective percentage reach 93.3%, cure rate 50.0%.

Description

A kind of Chinese medicine composition treating nephropathy and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating nephropathy and preparation method thereof.
Background technology
Nephropathy is the diseases of urinary system of one group of serious harm people's health, most recurrent exerbation, and delay difficulty more, is controlled Treat difficulty the biggest.Particularly when nephropathy is through repeatedly showing effect, the state of an illness can not get controlling or not obtaining the effective treatment, and all may Develop into renal failure, finally develop into uremia.And once develop into uremia, it is equal to indirectly declare the kidney of patient Function will be completely lost.Killer's type disease that it is referred to as by physician, and have the trend being gradually increased in recent years.Due to kidney Sick pathogeny is sufficiently complex, and clinical manifestation is varied, therefore, there is no the specific medicament for the treatment of nephropathy in the market. Western medical treatment typically uses antibiotics to treat, although this therapy onset is very fast, can alleviate disease, but Long-term taking medicine Bring bigger side effect easily to the most defective nephrotic of renal function.
The traditional Chinese medical science is thought, nephropathy is to be attacked by exopathogen, and labor is intended to excessively, and it is caused that prolonged illness consumption hinders vital essence etc..Therefore control suitable kidney tonifying, essence replenishing, Nourishing yin and warming yang, improving inspiration by invigorating the kidney, activate yang row water.
According to theory of Chinese medical science, for the pathogeny of nephropathy, carry out dialectical composition of prescription, to reach the mesh for the treatment of both the principal and secondary aspects of a disease 's.
Summary of the invention
It is an object of the invention to provide a kind of with low cost, toxic and side effects is little, effect significantly treats the Chinese drug-treated group of nephropathy Compound.
The second object of the present invention is to provide the preparation method of described Chinese medicine composition.
For achieving the above object, present invention firstly provides a kind of Chinese medicine composition treating nephropathy, described Chinese medicine composition It is made up of the raw material of following weight portion: Folium Kaki 25-35 part, Radix Rehmanniae Preparata 10-16 part, Radix Rehmanniae 9-15 part, Ramulus Cinnamomi 5-10 part, the Radix Astragali 5-15 part, Radix Angelicae Dahuricae 11-16 part, Hedyotidis Diffusae 11-15 part, Semen Plantaginis 10-12 part, Radix Angelicae Sinensis 6-9 part, Radix Morindae Officinalis 8-10 part, Cornu Cervi Glue 5-8 part, Rhizoma Dioscoreae 8-12 part, Fructus Lycii 8-15 part, Semen Cuscutae 6-9 part, Radix Glycyrrhizae 10-16 part.
Preferably, described Chinese medicine composition is made up of the raw material of following weight portion: Folium Kaki 30 parts, Radix Rehmanniae Preparata 12 parts, the Radix Rehmanniae Yellow 10 parts, Ramulus Cinnamomi 7 parts, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Hedyotidis Diffusae 12 parts, Semen Plantaginis 11 parts, Radix Angelicae Sinensis 6 parts, Radix Morindae Officinalis 9 parts, deer 6 parts of angle glue, Rhizoma Dioscoreae 10 parts, Fructus Lycii 12 parts, Semen Cuscutae 8 parts, 15 parts of Radix Glycyrrhizae.
Preferably, the dosage form of described Chinese medicine composition includes capsule, tablet, powder or granule.
Used by the present invention, each component pharmacologic action is as follows:
Folium Kaki, bitter in the mouth, cold in nature, nontoxic, enter lung meridian, Folium Kaki is used as medicine the most with a long history, its effect " book on Chinese herbal medicine is new ", In the medical science ancient books and records such as " book on Chinese herbal medicine derivative ", " Chinese herbology ", " Chinese medicine voluminous dictionary " the most on the books.The traditional Chinese medical science is thought: Folium Kaki can be with cephalocathartic Improving eyesight, anti inflammation and heat resolution, reduce blood pressure, increase heart coronary artery blood flow, prevent effect such as synthesis of inferior ammonium nitrate in human body, Often drink and can promote body tissue metabolism.It contains rutin, choline, protein, mineral, sugar etc., and prominent is every In 100 grams of dry Folium Kaki, Determination of Vitamin C reaches about 3500 milligrams.National distinguished veteran doctors of TCM is old always explicitly points out: Folium Kaki is the least Just, logical stool, have positive effect purifying the blood, in terms of vessel softening, blood pressure lowering.The experience of Yi Shi China national level distinguished veteran doctors of TCM is used Medicine, many gather materials also demonstrate this point.Additionally, modern study also demonstrates that in Folium Kaki containing Folium Kaki pyrite glycoside, ursolic acid Deng the component useful to nephropathy.
Radix Rehmanniae: GUIXIN, liver, kidney channel.Radix Rehmanniae is cool in nature, sweet-bitter flavor, have enriching yin and nourishing kidney, nourish blood enrich blood, effect of removing heat from blood.All Deficiency of YIN blood deficiency person who suffer from deficiency of kidney Yang eats it, the most helpful.Additionally, Radix Rehmanniae has heart tonifying diuresis, antipyretic antiinflammatory, promotes blood coagulation and reduce blood The effect of sugar.
Radix Rehmanniae: sweet, cold.Clearing away heat and cooling blood, yin nourishing, promote the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior Heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata: sweet, tepor.Nourishing YIN and supplementing blood, benefit essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, hectic fever due to YIN-deficiency tide Heat, night sweat passes out semen, and interior-heat quenches one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizziness, tinnitus, early whitening of beard and hair.
Ramulus Cinnamomi, acrid, sweet, warm, GUIXIN, lung, bladder warp, diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For Anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
The Radix Astragali, nature and flavor are sweet, warm, return lung, spleen channel, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weary for the deficiency of vital energy Power, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not holds back, blood Empty dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
The Radix Angelicae Dahuricae, pungent, warm, return stomach, large intestine, lung meridian, dissipate wind dehumidifying, sensible pain relieving, detumescence and apocenosis.
Hedyotidis Diffusae, sweet, light, cool;Enter stomach, large intestine, small intestine meridian, heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For intestinal Carbuncle (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the disease such as dysuria;Furuncle carbuncle, venom are controlled in external.
Semen Plantaginis, sweet, be slightly cold, return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.For edema Distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Radix Angelicae Sinensis, sweet, acrid, warm, return liver, the heart, spleen channel, replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy Dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Morindae Officinalis, sweet, pungent, tepor;Return kidney, Liver Channel, kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is not Pregnant, menoxenia, few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Colla cornus cervi, returns kidney, Liver Channel;Temperature compensation Liver and kidney, benefit intensive culture blood, for sexual impotence spermatorrhea, waist knee joint acid is cold, and asthenia weakness and emaciation collapses Leak down blood, hematuria of having blood in stool, and carbuncle of yin nature swells and ache.
Rhizoma Dioscoreae, nature and flavor are sweet, flat, return spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, Incessant chronic diarrhea, the deficiency of the lung breathes with cough, and emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Fructus Lycii, nature and flavor are sweet, flat, return liver, kidney channel, nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, dizziness Tinnitus, interior-heat quenches one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Semen Cuscutae, sweet, warm, return liver,kidney,spleen warp.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Lose for sexual impotence Essence, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down.
Radix Glycyrrhizae, sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, it is in harmonious proportion all Medicine.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, abirritant Thing toxicity, strong.
Pharmaceutical formulation of the present invention is with Folium Kaki, Radix Rehmanniae as monarch drug, dispersing cold for relieving pain, warming the meridian for stopping bleeding, detoxicating, relieving inflammation;With Ramulus Cinnamomi, The Radix Astragali, the Radix Angelicae Dahuricae, Hedyotidis Diffusae, Semen Plantaginis are ministerial drug, the hemostasis of nourishing the liver and kidney, promoting the flow of QI-blood by warming the meridian, dissipating blood stasis, subduing swelling and relieving pain;With Radix Angelicae Sinensis, bar Halberd sky, Colla cornus cervi, Rhizoma Dioscoreae, Fructus Lycii, Semen Cuscutae are adjuvant drug, invigorating the spleen and replenishing QI, replenishing and activating blood, menstruction regulating and pain relieving;With Radix Glycyrrhizae for making medicine, temperature Kidney cold expelling, promote the production of body fluid moisturize, promoting the circulation of QI to relieve pain, dispel the wind the wettest;And with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make all medicines arrange in pairs or groups, synergism, jointly Reach to reinforce the kidney, the effect such as heat-clearing and toxic substances removing, promoting the flow of QI-blood by warming the meridian, uremia is had the most significant therapeutic effect.
Further, the invention provides one and prepare Chinese medicine composition method, it comprises the following steps:
(1) prepare Folium Kaki, Folium Kaki is carried out, selects, goes handle, parch and pulverizing;
(2) weigh other each crude drug according to formula proportion, pulverize respectively, standby;
(3) taking all medical materials, add medical material weight 5-8 times weight water and soak 1-2 hour, intense fire decocts boiling 5-10 and divides Clock, then with slow fire boiling 3-5 hour, filter, obtain filtrate;Adding 2-4 times of weight water of initial medical material in filtering residue, intense fire decocts Seething with excitement 5-10 minute, then with slow fire boiling 1-2 hour, filter, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is dense It is reduced to the concentrated solution that relative density is 1.3-1.5 standby.
Beneficial effect
Chinese medicine composition disclosed by the invention, each component all uses natural raw material of Chinese medicine, its preparation is easy, medicine source is wide, Low cost.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug use the use that is decocted in water for oral dose.Verify by clinic application, Treatment nephropathy evident in efficacy reliably, mild in medicine property and, do not occur that toxic and side effects, effective percentage reach 93.3%, cure rate 50.0%.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.If not specializing, embodiment The conventional means that technological means used by is well known to those skilled in the art.
The compatibility 1 of embodiment 1 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 30 parts, Radix Rehmanniae Preparata 12 parts, Radix Rehmanniae 10 parts, Ramulus Cinnamomi 7 parts, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Hedyotidis Diffusae 12 parts, Semen Plantaginis 11 parts, Radix Angelicae Sinensis 6 parts, Radix Morindae Officinalis 9 parts, Colla cornus cervi 6 parts, Rhizoma Dioscoreae 10 parts, Fructus Lycii 12 parts, Tu SIZI 8 parts, 15 parts of Radix Glycyrrhizae.
Preparation method is as follows:
(1) prepare Folium Kaki, gather the Folium Kaki fresh, without pest and disease damage, without pesticide in 4-6 month and be carried out;Remove Folium Kaki Petiole, and Folium Kaki is torn into less leaf block, drains with after clean water;Subsequently with iron pan parch Folium Kaki, the temperature of parch It is advisable with 50-60 DEG C, and notes during parch stirring Folium Kaki, to prevent Folium Kaki by parching to brown, affect the treatment;
(2) weigh other each crude drug according to formula, pulverize respectively, standby;
(3) taking all medical materials, add 6 times of weight water of medical material weight and soak 1.5 hours, intense fire decocts boiling 5 minutes, then uses Slow fire boiling 4 hours, filters, obtains filtrate;Adding 3 times of weight water of initial medical material in filtering residue, intense fire decocts boiling 5 minutes, Again with slow fire boiling 2 hours, filtering, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is concentrated into relative density and is The concentrated solution of 1.4 is standby.
The compatibility 2 of embodiment 2 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 35 parts, Radix Rehmanniae Preparata 16 parts, Radix Rehmanniae 12 parts, Ramulus Cinnamomi 5 parts, the Radix Astragali 6 parts, the Radix Angelicae Dahuricae 13 parts, Hedyotidis Diffusae 13 parts, Semen Plantaginis 10 parts, Radix Angelicae Sinensis 8 parts, Radix Morindae Officinalis 9 parts, Colla cornus cervi 7 parts, Rhizoma Dioscoreae 11 parts, Fructus Lycii 12 parts, Tu SIZI 7 parts, 12 parts of Radix Glycyrrhizae.
Preparation method is as follows:
(1) prepare Folium Kaki, gather the Folium Kaki fresh, without pest and disease damage, without pesticide in 4-6 month and be carried out;Remove Folium Kaki Petiole, and Folium Kaki is torn into less leaf block, drains with after clean water;Subsequently with iron pan parch Folium Kaki, the temperature of parch It is advisable with 50-60 DEG C, and notes during parch stirring Folium Kaki, to prevent Folium Kaki by parching to brown, affect the treatment;
(2) weigh other each crude drug according to formula, pulverize respectively, standby;
(3) taking all medical materials, add 5 times of weight water of medical material weight and soak 2 hours, intense fire decocts boiling 5 minutes, then with civilian Fire decocts 3 hours, filters, obtains filtrate;Adding 3 times of weight water of initial medical material in filtering residue, intense fire decocts boiling 5 minutes, then With slow fire boiling 1 hour, filtering, obtain filtrate and retain filtering residue, merging twice filtrate, it is 1.3 that filtrate is concentrated into relative density Concentrated solution standby.
The compatibility 3 of embodiment 3 persimmon fruit leaves health-care tea and preparation method
Each parts by weight of raw materials is as follows: Folium Kaki 25 parts, Radix Rehmanniae Preparata 10 parts, Radix Rehmanniae 9 parts, Ramulus Cinnamomi 5 parts, the Radix Astragali 5 parts, the Radix Angelicae Dahuricae 14 Part, Hedyotidis Diffusae 14 parts, Semen Plantaginis 10 parts, Radix Angelicae Sinensis 8 parts, Radix Morindae Officinalis 9 parts, Colla cornus cervi 5 parts, Rhizoma Dioscoreae 12 parts, Fructus Lycii 15 parts, Herba cuscutae Son 9 parts, 16 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Clinical practice example
1, clinical observation case 30 example, age 30~80 years old, male 18 examples, female 12 example.
2, usage and dosage: during clinical practice, the component in compositions takes the circumstances into consideration increase and decrease according to body weight and the age of patient.One day Potion, decocting twice extracting juice about 300ml, divides and takes for early, middle and late three times.It within one month, it is a course for the treatment of.
3, criterion of therapeutical effect:
(1) recovery from illness: sings and symptoms disappears or substantially disappears;
(2) effective: sings and symptoms major part takes a turn for the better;
(3) effective: a sings and symptoms part takes a turn for the better;
(4) invalid;Sings and symptoms is all not improved, and symptom is the most front.
4, therapeutic effect: in this clinical observation case, take medicine 1-3 the course for the treatment of, 15 examples of fully recovering, effective 6 examples, effective 7 examples, nothing Imitate 2 examples.Toxic and side effects does not occurs during treatment, and effective percentage reaches 93.3%, cure rate 50.0%.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but On the basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Cause This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.

Claims (5)

1. the Chinese medicine composition treating nephropathy, it is characterised in that described Chinese medicine composition is by the raw material group of following weight portion Become: Folium Kaki 25-35 part, Radix Rehmanniae Preparata 10-16 part, Radix Rehmanniae 9-15 part, Ramulus Cinnamomi 5-10 part, Radix Astragali 5-15 part, Radix Angelicae Dahuricae 11-16 part, Hedyotidis Diffusae 11-15 part, Semen Plantaginis 10-12 part, Radix Angelicae Sinensis 6-9 part, Radix Morindae Officinalis 8-10 part, Colla cornus cervi 5-8 part, Rhizoma Dioscoreae 8-12 part, Fructus Lycii 8-15 part, Semen Cuscutae 6-9 part, Radix Glycyrrhizae 10-16 part.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that described Chinese medicine composition is by the raw material of following weight portion Composition: Folium Kaki 30 parts, Radix Rehmanniae Preparata 12 parts, Radix Rehmanniae 10 parts, Ramulus Cinnamomi 7 parts, the Radix Astragali 8 parts, the Radix Angelicae Dahuricae 12 parts, Hedyotidis Diffusae 12 parts, car First sub 11 parts, Radix Angelicae Sinensis 6 parts, Radix Morindae Officinalis 9 parts, Colla cornus cervi 6 parts, Rhizoma Dioscoreae 10 parts, Fructus Lycii 12 parts, Semen Cuscutae 8 parts, 15 parts of Radix Glycyrrhizae.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that the dosage form of described Chinese medicine composition includes capsule Agent, tablet, powder or granule.
4. Chinese medicine composition as claimed in claim 1, it is characterised in that described nephropathy includes chronic glomerulonephritis, concealment Property nephritis, pyelonephritis, the nephrotic syndrome, IgA nephropathy, diabetic nephropathy, hypertensive nephropathy.
5. preparing a Chinese medicine composition method, it comprises the following steps:
(1) prepare Folium Kaki, Folium Kaki is carried out, selects, goes handle, parch and pulverizing;
(2) weigh other each crude drug according to formula proportion, pulverize respectively, standby;
(3) taking all medical materials, add medical material weight 5-8 times weight water and soak 1-2 hour, intense fire decocts boiling 5-10 minute, then With slow fire boiling 3-5 hour, filter, obtain filtrate;Adding 2-4 times of weight water of initial medical material in filtering residue, intense fire decocts boiling 5-10 minute, then with slow fire boiling 1-2 hour, filter, obtain filtrate and retain filtering residue, merging twice filtrate, filtrate is concentrated into Relative density is that the concentrated solution of 1.3-1.5 is standby.
CN201610649186.2A 2016-08-10 2016-08-10 A kind of Chinese medicine composition treating nephropathy and preparation method thereof Pending CN106177326A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397438A (en) * 2011-11-12 2012-04-04 句文宝 Medicine for treating low renal function

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397438A (en) * 2011-11-12 2012-04-04 句文宝 Medicine for treating low renal function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
常学辉 编著: "《快乐生活一点通:生活中来的10000个窍门》", 31 January 2014, 天津出版传媒集团,天津科学技术出版社 *

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Application publication date: 20161207