CN102579610A - Chinese medicinal composition for treating cerebral hemorrhage and preparation method thereof - Google Patents
Chinese medicinal composition for treating cerebral hemorrhage and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating cerebral hemorrhage, which relates to the technical field of Chinese medicine. The composition consists of the following components in parts by weight: 8-16 parts of leech, 6-18 parts of giant knotweed, 8-16 parts of astragalus, 6-14 parts of safflower, 10-20 parts of pseudo-ginseng root, 10-20 parts of common selfheal fruit-spike, 10-20 parts of red paeony root, 6-16 parts of chaff flower root, 6-12 parts of ginkgo leaf and 6-18 parts of liquoric root. The Chinese medicinal composition for treating cerebral hemorrhage has the advantages of reasonable composition, short treatment course, high curing rate, no sequelae, safety, reliability and low price. The invention further provides a preparation method for the Chinese medicinal composition for treating cerebral hemorrhage; and the method has a simple process, and is suitable for industrial mass production.
Description
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of Chinese medicine composition of treating cerebral hemorrhage and preparation method thereof.
Background technology
Cerebral hemorrhage is wherein a kind of of apoplexy, and it is anxious to have onset, changes soon, causes the high characteristics of disability rate and case fatality rate, has a strong impact on patient's existence quality of life.The cause of disease of cerebral hemorrhage is a lot, can be divided into damaging and non-damage two big classes.Non-damage cerebral hemorrhage about 90% has hypertension history, in case hemorrhage, cause brain local blood circulation obstacle, cause the ACI symptom, be common how with hemiplegia, aphasia, stupor etc.Craniocerebral trauma causes cerebral hemorrhage at ordinary times, and the craniocerebral trauma that industrial injury, vehicle accident cause is very common, and in wartime, various weapons and abominable battlefield surroundings all might cause intracranial hemorrhage.
The cerebral hemorrhage treatment method has two kinds, and a kind of is operation, and another kind is to take medicine.Think at present, need not the hands art more during the unconscious obstacle of patient; Having obvious disturbance of consciousness, cerebral hernia still not clear is that surgical intervention obviously is superior to internal medicine; Deep coma patient, double vision enlarge, vital sign is tending towards depleted person, and the medical and surgical treatment method is all undesirable.Cranium is opened in operation, exists medical expense big, and sequela is more serious, the mortality rate problem of higher, though the patient who has has kept life, Cranial nerve injury as birth trauma in various degree can appear in about 90% patient, causes to can't take care of oneself or become the plant man.When in patient's brain during hematocele 5～40 ml, adopt intravenously administrable usually, about 30% patient can cure, and about 50% patient can't cure, and about 20% the patient state of an illness on the contrary can increase the weight of, even causes death, and its curative effect is low.In addition, the patient of hematocele is through taking existing Chinese patent medicine or Western medicine etc. in the brain, and its medicine time is long, and sb.'s illness took a favorable turn slowly, and cure rate has only 10～20%, and its curative effect is low equally.
Existing internal medicine Comprehensive Treatment is with furosemide, and the mannitol dehydration reduces intracranial pressure, and 17-hydroxy-11-dehydrocorticosterone reduces capillary permeability; And stool adopts calcium antagonist nimodipine etc. to improve the cerebral vasospasm situation in due course; Therefore, existing conventional therapy is more numerous and diverse, is easy to incur loss through delay first aid opportunity; And different degree have untoward reaction such as upper gastrointestinal hemorrhage, the infringement of kidney merit.
Traditional Chinese medicine has some unique Therapeutic Method to the cerebrovascular hemorrhage, and research has especially in recent years obtained some effects that attract people's attention, like Hirudo extract, and XINGNAOJING ZHUSHEYE etc.
Chinese patent CN100384464C discloses a kind of medicine of treating cerebral hemorrhage, by 8 ~ 12 parts of Herba Melastomatis dodecandri roots, and 10 ~ 20 parts of Herba Pileae Scriptaes, 10 ~ 15 parts of Radix Acanthopanacis Trifoliatis, 6 ~ 20 parts of Radix Cirsii Japonicis; 15 ~ 25 parts of Radix Salviae Miltiorrhizaes, 10 ~ 20 parts of Radix Ilicis Pubescentiss, 20 ~ 30 parts of Ramulus Moris, 10 ~ 15 parts of Herba Leonuris; 12 ~ 20 parts of Fructus Ligustri Lucidi, 10 ~ 20 parts of Radix Achyranthis Bidentataes, Rhizoma Acori Graminei waits composition for 10 ~ 15 parts, and clinical efficacy is good; But this medicine is taken and is mostly that inconvenience, every day need the 280g Chinese crude drug to decoct every day three times, each oral 150ml.
Chinese patent CN1254255C discloses a kind of oral liquid and compound method thereof with Hirudo treatment cerebral hemorrhage, by Hirudo: Radix Notoginseng: Radix Et Rhizoma Rhei=form at 6: 1: 2.This product has the blood circulation promoting and blood stasis dispelling function, promotes the effect of intracranial hematoma absorption; Can make the absorption of hematoma time in advance, be applicable to Acute Cerebral Hemorrhage, the treatment total effective rate reaches 95%.But this Hirudo compound oral liquid can not need to cooperate other treatment cerebral hemorrhage medicine or method together to use independently as the drug use of treatment cerebral hemorrhage.
Chinese invention patent CN1141121C the invention discloses a kind of medicine of cerebral hemorrhage clinical emergency treatment, and it is to be raw material with Cornu Bubali, Moschus, Radix Scutellariae, Radix Paeoniae Rubra, Radix Notoginseng, Radix Rehmanniae, is mixed with the Chinese patent medicine injection in proportion according to the different qualities of every flavor Chinese medicine.But Chinese medicine complicated component, effective ingredient it be unclear that etc., bring certain difficulty for preparation and the quality control of Chinese medicine, and the Chinese medicine injection safety problem also gets more and more these years.
Summary of the invention
The object of the present invention is to provide a kind of reasonable recipe, short treating period cure rate high, do not stay Chinese medicine composition of sequela and safe and reliable cheap treatment cerebral hemorrhage and preparation method thereof.
In order to realize the object of the invention, Chinese medicine composition of the present invention is processed by the raw material of following weight portion: Hirudo 8-16 part, Rhizoma Polygoni Cuspidati 6-18 part, Radix Astragali 8-16 part, Flos Carthami 6-14 part, Radix Notoginseng 10-20 part, Spica Prunellae 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Achyranthis Bidentatae 6-16 part, Folium Ginkgo 6-12 part, Radix Glycyrrhizae 6-18 part.
Preferably, Chinese medicine composition of the present invention is processed by the raw material of following weight portion: 10 parts of Hirudos, 9 parts of Rhizoma Polygoni Cuspidati, 12 parts of the Radixs Astragali, 10 parts on Flos Carthami, 14 parts of Radix Notoginseng, 10 parts of Spica Prunellaes, 12 parts of Radix Paeoniae Rubra, 10 parts of Radix Achyranthis Bidentataes, 6 parts of Folium Ginkgos, 12 parts in Radix Glycyrrhizae.
The traditional Chinese medical science is thought, all apoplexy all are " overabundant YIN leading to insufficient YANG " syndromes that kidney-Yang declines and decreases.Cerebral hemorrhage, the symptom of " excessive YIN keeping YANG externally " positive adverse QI rushing upwards of causing exactly.The sun adverse QI rushing upwards gathers in brain, and can not return unit.Mutual synergism can be held up its very unit between Chinese medicine composition of the present invention, takes into account the position of pathogenic factor simultaneously, has reached the effect of setting upright and uncharming.
Side of the present invention separates:
Hirudo: be the traditional extraordinary medicinal aquatic animal of China, its dry products is concocted the back traditional Chinese medical science and is used as medicine, and has effects such as treatment apoplexy, hypertension, the clear stasis of blood, amenorrhea, traumatic injury.In recent years new discovery Hirudo preparation has specially good effect at control cardiovascular and cerebrovascular disease and anticancer aspect.The effect of expansion blood capillary, microcirculation improvement, increase renal blood flow amount is arranged.The effect of its microcirculation improvement, similar with heparin, just action time is of short duration.Experiment shows: Hirudo has the effect of expansion peripheral blood vessel, blood flow increasing and minimizing vascular resistance.
Rhizoma Polygoni Cuspidati: little hardship is slightly cold.Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
Flos Carthami: warm in nature, acrid in the mouth.Function cures mainly promoting blood circulation to restore menstrual flow, and the silt pain relieving of loosing is used for amenorrhea, dysmenorrhea, and lochia is not all right, the lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.When ancients often have what blood in vivo, often add the Flos Carthami tate.Modern pharmacology discovers that Flos Carthami has slight excited heart, reduces coronary resistance, increases the effect of coronary flow and myocardial nutrition property blood flow. and Flos Carthami injection, alcohol extract, carthamin can significantly improve the hypoxia-bearing capability of mice. and Flos Carthami has protective effect to hypoxic-ischemic encephalopathy (HIE).
The Radix Astragali: nature and flavor: sweet, tepor.The Radix Astragali has benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.Its flavor is light, so specially reach table in edema caused by disorder of QI, so ability complement sun fills space between skin and muscles, controls impairment caused by overstrain, longue meat.The deficiency of vital energy and difficult antiperspirant person can send out, table is dredged and hyperhidrosis person can end.So its hemostasis person of collapsing the stranguria with blood, blood is from ending also with gas-solid.
Radix Notoginseng: give birth to usefulness, warm in nature, sweet in the mouth, little hardship.Gui Jing: return liver, stomach warp.Hemostasis, antithrombotic, dissipating blood stasis, detumescence, pain relieving.Has the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.Cure mainly: control haematemesis, hemoptysis, epistaxis, dysentery, metrorrhagia, lump in the abdomen falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain." beautiful Chinese catalpa medicine is separated " cloud: " Radix Notoginseng and battalion hemostasis, the clots absorbing of promoting blood circulation, clots absorbing blood and hold back fresh blood ".
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stasis of blood stagnates that amenorrhea, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Function with clearing away heat and cooling blood, eliminating stasis to stop pain.Giving birth to Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.The fever of the body that is used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases hemorrhage more, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.
Radix Achyranthis Bidentatae: liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow; Ignite (blood) descending; Inducing diuresis for treating stranguria syndrome cures mainly: soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; The carbuncle malignant boil; Laryngopharynx swelling and pain.
Folium Ginkgo: sweet, bitter, puckery, flat.GUIXIN, lung meridian.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid.
Spica Prunellae: bitter, hot, cold.Control conjunctival congestion and swelling pain, headache.Clearing away liver-fire is controlled hypertension, hyperlipidemia, high blood viscosity and hyperglycemia.
Radix Glycyrrhizae: Radix Glycyrrhizae, sweet in the mouth, gas is flat, and is warm in nature, can rise and can fall, and positive middle-jiao yang, function of the spleen and stomach is invigorating the spleen and replenishing QI also, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form; For example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
According to Clinical Experience, Chinese medicine composition of the present invention is preferably oral liquid.
The concrete method for preparing of oral liquid of the present invention is following:
1) fetch water according to the above ratio trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder is broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, each 2h, and the merging ethanol extract is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder according to the above ratio and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
Advantage of the present invention is: to modern medicine screening of medicaments to the sick treatment of cerebral hemorrhage and scientifically; Prescription of the present invention is collaborative each other to have blood stasis alive, hemorrhage, removing heat by catharsis expells the pathogenic heat only; Dwindle intracerebral hematoma, reduce intracranial pressure, alleviate the effects such as recovery that cerebral edema has promoted function of nervous system.Cure mainly cerebral hemorrhage, cerebral thrombosis, and sequela, hemiplegia that should disease caused be particularly useful for Acute Cerebral Hemorrhage, and curative effect is high, has no side effect, and the treatment total effective rate reaches 98%, therefore the treatment cerebral hemorrhage are had extremely important meaning.
In addition, no valuable article among the present invention, used Chinese medicine source is sufficient, no in great shortage, and its preparation technology is easy to grasp, and that obeys is safe and reliable, has no side effect, and is easy to apply.
1, Chinese medicine composition animal acute toxicity test of the present invention
Medicine: the embodiment of the invention 1 prescription.
Experimental animal: 12 of regular grade NIH mices, body weight 18g ± 2g, male and female half and half.
Method and result: be divided into the blank group at random, fasting experimentized after 16 hours, and the administration group is irritated stomach by the dosage of 0.4ml/10g and given oral liquid of the present invention, the dosage gastric infusion of pressing 0.4ml/10g after 5 hours again once, twice totally.Meanwhile the blank group is irritated stomach and is given same water by volume, observes after the administration and raises seven days, and the record mouse toxicity reacts and death condition, and observes the variation of its main organs and tissue.
Conclusion: under the situation of Cmax 150g/ml that oral liquid of the present invention can be prepared (containing the crude drug amount) and maximum volume 0. 4ml/10g administration, be administered twice to mouse stomach in one day, do not see that other toxic reaction takes place: administration after seven days mice do not have death; Behavior is active; Food ration is as usual, and the hair color light does not have loose dirty, and not having faints from fear has a liking for saliva; Eye, mouth, nose, ear and the no abnormal secretions of crissum do not have the mashed toe of docking.Put to death mice, dissect, observe main organs such as its heart, liver, lung, kidney and organize no abnormality seen, show the oral safety of this medicine.
, Chinese medicine composition long-term toxicity test for animals of the present invention
Medicine: the embodiment of the invention 1 prescription.
Animal: 24 of regular grade SD rats, body weight 200g ± 10g, male and female half and half are divided into 3 groups at random.
Method and result:
1) medicine preparation: divide high and low, blank three dose groups, be respectively 150,75,0 times of clinical application amount.
2) the gastric infusion mode is adopted in experiment; All by the capacity gastric infusion of 1ml/100g; Successive administration 90 days: the blank group is given the distilled water of the capacity of grade every day; Every then treated animal is put to death 4, becomes celestial each organs and tissues of animal is carried out perusal, and organs such as the heart, liver, spleen, lung, kidney, adrenal gland, thymus are done the pathology inspection.
Conclusion: feed during 1, each treated animal is tried, drinking-water, defecation are all normal, motion healthy active, by a hair gloss, find dead and other ANOMALOUS VARIATIONS.2, each treated animal body weight gain is normal, administration group and matched group comparison there was no significant difference (P>0.05).3, experiment each treated animal hepatic and renal function of back and serum biochemistry mensuration result and matched group compare there was no significant difference.4, experiment each treated animal hemogram checking of back and matched group compare there was no significant difference.5, each treated animal heart, liver, spleen, lung, kidney, adrenal gland, thymus outward appearance and its organ index there are no significant difference.6, each treated animal is the same with matched group, and the size and form of organs such as the heart, liver, spleen, lung, kidney is normal basically, smooth surface; No hemorrhage, adhesion or necrosis, histological examination are respectively organized internal organs and are not all seen organic disease; Cardiac muscle fiber does not have degeneration or necrosis, and structure is normal, and lung tissue and spleen are organized also no abnormality seen change; The all no abnormal changes of structure such as hepatocyte and glomerule, renal tubules, promptly relevant with drug metabolism important organ does not all have obvious change.
3, Chinese medicine composition clinical effectiveness situation of the present invention:
Choose through Cranial Computed Tomography or MRI and check cerebral hemorrhage clinical case 294 examples of making a definite diagnosis (male's 194 examples, women's 100 examples), oldest 81 years old, minimum 39 years old.Be all the patients with cerebral hemorrhage of being in hospital 1-30 days.All give Chinese medicinal composition preparation embodiment 1 oral liquid 10ml of the present invention; 3 times on the one, 14 days one courses of treatment, the 14th day check head CT after the medication; The 28th day or carry out the scoring of nervous function damage improvement degree when leaving hospital, to observe absorption of hematoma situation and efficacy evaluation.
Clinical symptoms: in patients with cerebral hemorrhage 294 examples, can spout food stream juice gruel, panplegia paralysis 51 examples (male 38 examples, women 20 examples); Language celostomia, half body hemiplegia 121 examples (male 80 examples, women 41 examples); Can flow juice, upper limb hemiplegia 46 examples (male 32 examples, women 14 examples) for food; Can flow juice, lower limb hemiplegia 76 examples (male 44 examples, women 25 examples) for food.
In patients with cerebral hemorrhage 294 examples: putamen hemorrhage 10-30 CC 70 examples, the hemiplegia of leaning to one side; Cerebral lobar hemorrhage 30-50 CC 88 examples have headache, hemiplegia state; Pontine hemorrhage 20 ~ 30 CC 34 examples, patient's upper limb hemiplegia, facial hemiparalysis, dysphagia; Cerebellar hemorrhage 10-25CC 60 examples, patient's dysphagia, slurred speech, lower limb are inclined to one side, paralysis; Subarachnoid hemorrhage 42 examples have headache, semicoma, tic, gatism, the blind state of vision.
Criterion of therapeutical effect:
Cure: hemiplegic limb recovers 5 grades, and language performance does not have difficulty, and life can be taken care of oneself.
Produce effects: language performance is still not exclusively fluent, Myodynamia recovery 3-4 level, and life can be taken care of oneself or half self-care.
Effectively: vital sign is normal; Hemiplegic limb takes a turn for the better, Myodynamia recovery 2-3 level, and language performance is unfluent, can't take care of oneself.
Invalid: as to die from complication, clinical death.
Therapeutic outcome is analyzed
The present invention treats patients with cerebral hemorrhage 294 examples, total effective rate 98%, wherein: cure 250 examples, account for 85%; Produce effects 27 examples account for 9.2%; Effective 11 examples account for 3.8%; Invalid 6 examples account for 2%.
The specific embodiment
Below description through the specific embodiment the present invention is described further; But this is not to be limitation of the present invention; Those skilled in the art are according to basic thought of the present invention; Can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within scope of the present invention.
Embodiment 1: take by weighing Hirudo 10g, Rhizoma Polygoni Cuspidati 9g, Radix Astragali 12g, Flos Carthami 10g, Radix Notoginseng 14g, Spica Prunellae 10g, Radix Paeoniae Rubra 12g, Radix Achyranthis Bidentatae 10g, Folium Ginkgo 6g, Radix Glycyrrhizae 12g.
1) water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges ethanol extract and is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
Embodiment 2: take by weighing Hirudo 8g, Rhizoma Polygoni Cuspidati 6g, Radix Astragali 8g, Flos Carthami 6g, Radix Notoginseng 10g, Spica Prunellae 10g, Radix Paeoniae Rubra 10g, Radix Achyranthis Bidentatae 6g, Folium Ginkgo 6g, Radix Glycyrrhizae 6g.
1) water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges ethanol extract and is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
Embodiment 3: take by weighing Hirudo 16g, Rhizoma Polygoni Cuspidati 18g, Radix Astragali 16g, Flos Carthami 14g, Radix Notoginseng 20g, Spica Prunellae 20g, Radix Paeoniae Rubra 20g, Radix Achyranthis Bidentatae 16g, Folium Ginkgo 12g, Radix Glycyrrhizae 18g.
1) water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges ethanol extract and is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
Embodiment 4: take by weighing Hirudo 10g, Rhizoma Polygoni Cuspidati 14g, Radix Astragali 13g, Flos Carthami 13g, Radix Notoginseng 18g, Spica Prunellae 19g, Radix Paeoniae Rubra 18g, Radix Achyranthis Bidentatae 15g, Folium Ginkgo 6g, Radix Glycyrrhizae 6g.
1) water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges ethanol extract and is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
Embodiment 5: take by weighing Hirudo 16g, Rhizoma Polygoni Cuspidati 6g, Radix Astragali 8g, Flos Carthami 12g, Radix Notoginseng 18g, Spica Prunellae 16g, Radix Paeoniae Rubra 10g, Radix Achyranthis Bidentatae 12g, Folium Ginkgo 8g, Radix Glycyrrhizae 12g.
1) water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges ethanol extract and is evaporated to 0.5g/ml (containing the crude drug amount).
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and be concentrated into 0.5g/ml (containing the crude drug amount).
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, add water, stir, leave standstill, filter, fill, sterilization promptly gets.
Claims (5)
1. a Chinese medicine composition of treating cerebral hemorrhage is characterized in that being processed by the raw material of following weight portion: Hirudo 8-16 part, Rhizoma Polygoni Cuspidati 6-18 part, Radix Astragali 8-16 part, Flos Carthami 6-14 part, Radix Notoginseng 10-20 part, Spica Prunellae 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Achyranthis Bidentatae 6-16 part, Folium Ginkgo 6-12 part, Radix Glycyrrhizae 6-18 part.
2. like the Chinese medicine composition of the described treatment cerebral hemorrhage of claim l, it is characterized in that processing: 10 parts of Hirudos, 9 parts of Rhizoma Polygoni Cuspidati, 12 parts of the Radixs Astragali, 10 parts on Flos Carthami, 14 parts of Radix Notoginseng, 10 parts of Spica Prunellaes, 12 parts of Radix Paeoniae Rubra, 10 parts of Radix Achyranthis Bidentataes, 6 parts of Folium Ginkgos, 12 parts in Radix Glycyrrhizae by the raw material of following weight portion.
3. the Chinese medicine composition of treatment cerebral hemorrhage as claimed in claim 2 is characterized in that: said Chinese medicine composition is a peroral dosage form.
4. the Chinese medicine composition of treatment cerebral hemorrhage as claimed in claim 3 is characterized in that: said peroral dosage form is the liquid oral dosage form.
5. the method for preparing of the Chinese medicine composition of treatment cerebral hemorrhage as claimed in claim 4 is characterized in that comprising following processing step:
1) take by weighing raw material according to proportioning, water intaking trematodiasis, Flos Carthami, Radix Notoginseng, Spica Prunellae powder are broken into coarse powder, and with 50% alcohol dipping 2h, the back is made solvent refluxing with 10 times of amounts of coarse powder, 50% ethanol and extracted 2 times, and each 2h merges the ethanol extract concentrating under reduced pressure;
2) get Rhizoma Polygoni Cuspidati, the Radix Astragali, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Folium Ginkgo, Radix Glycyrrhizae powder and be broken into coarse powder, add 10 times of water gagings and decocted 2 hours, filter, collect filtrate decompression and concentrate;
3) combining step 1) step 2) concentrated solution, add correctives, antiseptic, stir, leave standstill, filter, fill, sterilization promptly gets.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103705789A (en) * | 2014-01-14 | 2014-04-09 | 庄成龙 | Pharmaceutical composition for treating cerebral hemorrhage |
| CN104306741A (en) * | 2014-09-26 | 2015-01-28 | 朱晓岩 | A traditional Chinese medicine formula for treating cerebral hemorrhage |
| CN105250765A (en) * | 2015-10-30 | 2016-01-20 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicinal preparation for treating acute cerebral hemorrhage and preparation method of traditional Chinese medicinal preparation |
| CN105381064A (en) * | 2015-11-16 | 2016-03-09 | 宁国仙霞骨伤医院 | Traditional Chinese medicine composition for treating cerebral hemorrhage |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1182604A (en) * | 1996-11-20 | 1998-05-27 | 甘肃省中医院 | Ointment for treating apoplexy |
| CN1695652A (en) * | 2004-05-12 | 2005-11-16 | 陕西爱波卓科技有限责任公司 | High performance oxidation resistant compsn. extracted from plant |
| JP2005350450A (en) * | 2004-05-10 | 2005-12-22 | Shogan Kan | Drug or food for prophylaxis/treatment of circulatory disorder and lifestyle-related disease |
| JP2009013083A (en) * | 2007-07-02 | 2009-01-22 | Noriyoshi Nakao | Orally administerable composition |
| WO2010053456A1 (en) * | 2008-11-10 | 2010-05-14 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| CN101884661A (en) * | 2009-05-14 | 2010-11-17 | 御盛隆堂药业有限责任公司 | Traditional Chinese medical preparation containing leeches and astragalus and used for treating cardiovascular and cerebrovascular diseases |
| CN102048888A (en) * | 2009-10-27 | 2011-05-11 | 菲伯纳生物医药有限责任公司 | Pharmaceutical composition for eliminating thrombus |
| CN102198181A (en) * | 2011-05-24 | 2011-09-28 | 海城市中医院 | Antithrombotic and thrombosis-eliminating preparation |
| CN102228525A (en) * | 2011-06-27 | 2011-11-02 | 陈伯明 | Traditional Chinese medicine for treating cardio-cerebral vascular stagnation |
| CN102335203A (en) * | 2010-07-21 | 2012-02-01 | 张辉 | Miniature decoction |
-
2012
- 2012-04-01 CN CN 201210095485 patent/CN102579610B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1182604A (en) * | 1996-11-20 | 1998-05-27 | 甘肃省中医院 | Ointment for treating apoplexy |
| JP2005350450A (en) * | 2004-05-10 | 2005-12-22 | Shogan Kan | Drug or food for prophylaxis/treatment of circulatory disorder and lifestyle-related disease |
| CN1695652A (en) * | 2004-05-12 | 2005-11-16 | 陕西爱波卓科技有限责任公司 | High performance oxidation resistant compsn. extracted from plant |
| JP2009013083A (en) * | 2007-07-02 | 2009-01-22 | Noriyoshi Nakao | Orally administerable composition |
| WO2010053456A1 (en) * | 2008-11-10 | 2010-05-14 | Moleac Pte. Ltd. | Combination therapy for treatment of patients with neurological disorders and cerebral infarction |
| CN101884661A (en) * | 2009-05-14 | 2010-11-17 | 御盛隆堂药业有限责任公司 | Traditional Chinese medical preparation containing leeches and astragalus and used for treating cardiovascular and cerebrovascular diseases |
| CN102048888A (en) * | 2009-10-27 | 2011-05-11 | 菲伯纳生物医药有限责任公司 | Pharmaceutical composition for eliminating thrombus |
| CN102335203A (en) * | 2010-07-21 | 2012-02-01 | 张辉 | Miniature decoction |
| CN102198181A (en) * | 2011-05-24 | 2011-09-28 | 海城市中医院 | Antithrombotic and thrombosis-eliminating preparation |
| CN102228525A (en) * | 2011-06-27 | 2011-11-02 | 陈伯明 | Traditional Chinese medicine for treating cardio-cerebral vascular stagnation |
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| CN103705789A (en) * | 2014-01-14 | 2014-04-09 | 庄成龙 | Pharmaceutical composition for treating cerebral hemorrhage |
| CN103705789B (en) * | 2014-01-14 | 2014-08-06 | 梁存福 | Pharmaceutical composition for treating cerebral hemorrhage |
| CN104306741A (en) * | 2014-09-26 | 2015-01-28 | 朱晓岩 | A traditional Chinese medicine formula for treating cerebral hemorrhage |
| CN105250765A (en) * | 2015-10-30 | 2016-01-20 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicinal preparation for treating acute cerebral hemorrhage and preparation method of traditional Chinese medicinal preparation |
| CN105381064A (en) * | 2015-11-16 | 2016-03-09 | 宁国仙霞骨伤医院 | Traditional Chinese medicine composition for treating cerebral hemorrhage |
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