CN102198181A - Antithrombotic and thrombosis-eliminating preparation - Google Patents

Abstract

The invention relates to an antithrombotic and thrombosis-eliminating preparation, which is characterized by being prepared from the following raw material medicines in part by weight: 30 to 60 parts of astragalus, 3 to 6 parts of leech, 10 to 20 parts of safflower, 10 to 20 parts of red paeony root, 5 to 15 parts of root of red-rooted salvia and 10 to 20 parts of peach kernel. Compared with the prior art, the antithrombotic and thrombosis-eliminating preparation has the advantages that: based on the acute phase formation characteristics and pathological change of ishemic stroke, a compound Chinese medicine with effects of scattering and eliminating stasis, promoting dieresis and diminishing swelling is used to treat acute ishemic stroke; and lots of clinic tests prove that the antithrombotic and thrombosis-eliminating preparation has obvious treatment effects of preventing blood clotting, dissolving blood clots, expanding blood capillaries, relieving arteriospasm, lowering blood viscosity, improving flowing speed of microcirculating blood.

Description

The thromboembolism preventing thrombus diminishing agent

Technical field

The present invention relates to a kind of thromboembolism preventing thrombus diminishing agent for the treatment of apoplexy.

Background technology

Apoplexy also is apoplexy, is divided in the ischemic cerebral apoplexy and hemorrhagic apoplexy, and apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.The apoplexy sickness rate is along with the variation sickness rate of environment and dietary structure increases year by year at present, and the fatality rate that disables is quite high, has brought burden and economic loss to family social, so the research of apoplexy is the problem of medical profession common concern with treatment.The acute stage of cerebral infarction, generally can be carried out thromboembolism treatment in 3 hours; but most patients have missed the thrombolytic time when coming institute to go to a doctor; can only take calcium ion to pick up anti-agent and brain protection pharmaceutical treatment; in case hemostasis platelet cohesion; but often effect is unsatisfactory; the normal at present thrombolytic medicine that adopts has rt-PA or urokinase, and its side effect is bigger, causes angiorrbagia easily.

Summary of the invention

The purpose of this invention is to provide a kind of thromboembolism preventing thrombus diminishing agent,, adopt Chinese medicine partner treatment cerebral infarction according to the characteristics and the pathological change of acute cerebral ischemic stroke.

For achieving the above object, the present invention is achieved through the following technical solutions:

The medicament selection Radix Astragali of the present invention, Hirudo, Flos Carthami, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Semen Persicae make up, by these drug regimens being made each medicine effect produce synergism, can the blood circulation promoting and blood stasis dispelling embolism extinguishing, anticoagulant, acceleration microcirculation, blood viscosity lowering, prevent that microthrombus from forming again, improve the acute cerebral ischemic stroke disturbance of cerebral circulation.

The Radix Astragali of wherein selecting for use, warp warm in nature, as to return the spleen lung has the stagnant effect of QI invigorating row, is adapted to numb limbs and tense tendons, the hemiplegia of blood stagnancy due to deficiency of QI, has played the merit of " the capable then blood of gas is capable, qi being the governor of blood " in this side; Hirudo, Liver Channel is put down, returned to salty in the mouth hardship, property, this product is salty can walk blood, bitter can drop-down, go into Liver Channel, be removing blood stasis repercussive good medicine, modern pharmacological research, Hirudo contains hirudin, can prevent blood coagulation, blood clot dissolving, the expansion blood capillary, alleviate arteriospasm, blood viscosity lowering, microcirculation improvement; Flos Carthami, acrid in the mouth, warm in nature, the warp of GUIXIN liver is the product of promoting blood circulation to restore menstrual flow blood stasis dispelling, modern pharmacological research has protective effect to the ischemic hypoxia brain injury; Radix Paeoniae Rubra has the effect of clearing away heat and cooling blood blood stasis dispelling, and modern pharmacological research has the anti-platelet aggregation effect; Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature, GUIXIN liver two warps, its function blood circulation promoting and blood stasis dispelling stimulates the menstrual flow, and modern pharmacological research is thought can anticoagulant, activates fibrinolytic, quickens the microcirculation velocity of blood flow; Semen Persicae, bitter but sweet flavor, property is put down, GUIXIN liver, large intestine channel, bitter can drop-down leading down with removing blood stasis with potent drugs, sweet energy and smooth QI and blood are used this medicine with tissue regeneration promoting always so clots absorbing stimulates the menstrual flow.

The consumption that medicine of the present invention is formed is groped to sum up out through the inventor in a large number, and each amounts of components all has better curative effect in the following weight parts scope:

Radix Astragali 30-60 part, Hirudo 3-6 part, Flos Carthami 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Semen Persicae 10-20 part.

Be preferably: Radix Astragali 30g, Hirudo 5g, Flos Carthami 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 10g, Semen Persicae 15g.

The present invention can adopt the conventional method of Chinese medicine preparation to make any conventional oral preparations, for example can be with these crude drug decocting together, and the condensed water decocting liquid is oral then; Can also refine concentrated pill, crude drug is cleaned, dries, pulverize, sterilize, sieve, add honey then, close stick together, pill; Can also make powder, crude drug be cleaned dried, pulverize then, sterilize, sieve, insert in the Capsules.

Compared with prior art, the invention has the beneficial effects as follows: according to the characteristics and the pathological change of acute cerebral ischemic stroke formation, utilize the effect of the blood stasis dispelling of Chinese medicine composition medicine dissipating blood stasis, dampness removing, detumescence, be used for the treatment of the acute stage cerebral infarction, by a large amount of clinical trial checkings, has the blood coagulation of preventing, blood clot dissolving, the expansion blood capillary is alleviated arteriospasm, blood viscosity lowering, the significant curative effect of microcirculation improvement velocity of blood flow.

The specific embodiment

Be described further of the present invention below in conjunction with specific embodiment:

The present invention treats the clinical observation of cerebral infarction

1, physical data

Accept outpatient service and inpatient 800 examples for medical treatment, wherein male 500 examples, women 300 examples, men and women's ratio 5: 3, age 40-50 year 80 examples, 50-60 year 420 examples, 60-70 year 200 examples, 100 examples more than 70 years old.

2, diagnostic criteria, refer to go into arteries and veins with reference to " national standard is used tcm internal medicine disease treatment routine " cerebral infarction because of blood stasis expectorant is turbid, block due to the brain network, with hemiplegia crooked mouth and tongue, dysphonia, dysphagia, choke cough, hemianopsia aphasia etc. is the cardinal symptom disease, is equivalent to the said cerebral infarction of western medicine.

(1) Acute onset plays morbidity morning, or aprowl occurs clinical symptoms such as hemiplegia suddenly, good sending out in middle age; How chronic patient falls ill under states such as nighttime sleep or rest, good being sent out old age, and the male is more.

(2) before the morbidity, minority has headache dizzy or tendency such as numb limbs and tense tendons is arranged, and hemiplegia occurs after sick the sending out, dysphonia, choke cough, symptoms such as dysphagia, facial hemiparalysis, clumsy in one's movement, the instability of gait of sick the lighter, general unconscious obstacle.

(3) body temperature is breathed no significant change, and blood pressure can have rising.

3, auxiliary examination: Cranial Computed Tomography, scanning can not have obvious low-density kitchen range an acute stage, and CT scan can show the low-density focus of infarct after 24 hours, and magnetic resonance can be found focus of infarct in early days.

4, Therapeutic Method:

Concentrated pill, oral 3 times of every day, each 6 grams; Fry in shallow oil soup and concentrate, oral each 100 milliliters, day 3 times; Powder and capsule, days 3 times oral, one time 6, every 0.6 gram, two weeks were a course of treatment, logotype 2-3 course of treatment.

5, efficacy assessment standard

(1) cure: treatment back hemiplegia muscular strength, aphasis etc. recover normal, and life is all taken care of oneself;

(2) take a turn for the better: treatment back hemiplegia muscular strength all improves II level, life partial self-help;

(3) invalid: no change before and after the treatment.

6, therapeutic outcome (seeing Table 1)

Table 1 is observation of curative effect after treating

In a word, in six weeks, with Drug therapy cerebral infarction 800 examples of the present invention, the result cures 580 examples, cure rate 72.5%, 190 examples that take a turn for the better, invalid 30 examples, total effective rate 96.25%.

Embodiment 1

The condensed water decocting liquid preparation of medicine of the present invention

Get it filled Radix Astragali 30g, Hirudo 5g, Flos Carthami 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 10g, Semen Persicae 15g add water to 600 milliliters together with raw material, soak 30 minutes, and water boiling concentration to 300 milliliter is divided 3 times oral (daily dose).

Embodiment 2

The concentrated pill preparation of medicine of the present invention

Get Radix Astragali 350g, Hirudo 50g, Flos Carthami 140g, Radix Paeoniae Rubra 140g, Radix Salviae Miltiorrhizae 140g, Semen Persicae 140g, crude drug is cleaned, dries, pulverize then, sterilize, sieve, the 960g that gets it filled altogether adds honey in 1: 1 ratio, adds sweet 960g, closes the 1920g that sticks together, make 320 ball finished products, every ball 6g.

Embodiment 3

The powder and capsule preparation of medicine of the present invention

Get it filled Radix Astragali 30g, Hirudo 3g, Flos Carthami 10g, Radix Paeoniae Rubra 10g, Radix Salviae Miltiorrhizae 15g, Semen Persicae 10g clean medicine and dry, and pulverize then, sterilize, sieve, the 78g that gets it filled altogether, consume 15%, surplus only 66g, average 110 Capsuleses of packing, every 0.6g.

Claims (2)

1. the thromboembolism preventing thrombus diminishing agent is characterized in that, it comprise following bulk drugs by weight ratio make:

Radix Astragali 30-60 part, Hirudo 3-6 part, Flos Carthami 10-20 part,

Radix Paeoniae Rubra 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Semen Persicae 10-20 part.

2. thromboembolism preventing thrombus diminishing agent according to claim 1 is characterized in that, wherein each raw material medicines in portions by weight preferred proportion is:

Radix Astragali 30g, Hirudo 5g, Flos Carthami 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 10g, Semen Persicae 15g.