CN103251764B - A kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, each group of crude drug by weight ratio consists of 3 ~ 10 parts, Flos Carthami, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts, 8 ~ 12 parts, the Radix Rehmanniae, Rhizoma Cimicifugae 8 ~ 15 parts, Semen Arecae 7 ~ 10 parts, 2 ~ 5 parts, Radix Glycyrrhizae, 8 ~ 12 parts, Radix Rehmanniae Preparata, preparation method comprises crude drug pretreatment, grinding, soak, the step such as concentrated, solve traditional treatment cardiovascular and cerebrovascular diseases costly, the problem that toxic and side effects is large, have soon effective, effect is strong, many effects, with low cost, safe and reliable, the advantage that toxic and side effects is little.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof.
Background technology
Modern life rhythm is nervous, and the increasing pressure of family, cause is large, and the emotion of people is also more and more unstable; Simultaneously, excessive consumption of alcohol, the motion taken in too many food fat, lack necessity, in addition the pollution of living environment, the anion concentration in air sharply declines, and the anion taken in body is also just not enough, these factors directly cause human metabolism's speed to slow down, velocity of blood flow can slow down, and blood viscosity raises rapidly, causes cerebral ischemia, if prevent not in time, nurse one's health, the cardiovascular and cerebrovascular diseases such as coronary heart disease, hypertension, cerebral thrombosis, fatty liver will be caused.
At present, cardiovascular and cerebrovascular disease is a kind of serious threat human diseases, particularly affect the commonly encountered diseases of more than 50 years old middle-aged and elderly people health, even if the treatment means that application is most advanced, perfect at present, the cerebrovas-cularaccident survivor of more than 50% still can be had to live could not take care of oneself completely! The number of cardiovascular and cerebrovascular disease is died from every year up to 1,500 ten thousand people in the whole world, occupies the various cause of the death the first.Cardiovascular and cerebrovascular disease has become the highest number one killer of human death's cause of disease, is also health of people " noiseless demon ".
The symptom of this kind of case appears as more: giddy, caligation, tinnitus, breathe hard, angina pectoris, numbness of hands and feet, local pain, walking is unable, sitting is difficult, cardiopalmus, the strange sound of fearness noise, coronary heart disease, heart disease, apoplexy, color mostly are light black, atropurpureus.These sick great majority are because hypertension, hyperglycemia, the arteriosclerosis of hyperlipidemia appearance, the vascular flow reason such as mudflow sand, grain stream that is fuzzy and Hemodynamic environment appearance cause sclerosis of blood vessels no thoroughfare, blood stagnation blocking barrier, cerebral blood supply insufficiency and the disease caused.Meanwhile, the weakness of the spleen and stomach nutrient deficiency, the old stasis stream that cause due to the discord of negative and positive tune, plasma metabolism is irregular also likely causes these diseases.
Patent documentation application number CN201010506336.7 discloses " a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease ", this pharmaceutical composition is made up of active component and pharmaceutically acceptable adjuvant, described active component is by Radix Notoginseng 3 ~ 9 weight portion, the Radix Astragali 9 ~ 20 weight portion, Radix Salviae Miltiorrhizae 9 ~ 15 weight portion, the crude drug of Folium Ginkgo 9 ~ 12 weight portion and Fructus Crataegi 9 ~ 12 weight portion is made, this invention medicine has blood circulation and channel invigorating, effect of comfortable QI invigorating, but this prescription does not illustrate the hypertension caused for various symptom, hyperglycemia, the various thrombotic cardiovascular and cerebrovascular disease such as hyperlipidemia.
Patent documentation application number CN201010504684.0 discloses " a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease ", the present invention is a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease, and it is the powder that mixes of following former medicine by weight or powder capsule: Radix Notoginseng 1 part; 0.5 ~ 1.5 part, Flos Carthami; Hirudo 0.1 ~ 0.9 part; Radix Salviae Miltiorrhizae 1 ~ 2 part; Pheretima 0.5 ~ 1.5 part, also can add Radix Angelicae Sinensis 1 ~ 2 part; The Radix Paeoniae Alba 1 ~ 2 part, Rhizoma Chuanxiong 0.4 ~ 1.2 part; Radix Achyranthis Bidentatae 0.8 ~ 2 part; Ramulus Uncariae Cum Uncis 1 ~ 2 part; Radix Curcumae 0.5 ~ 1.5 part; Semen Platycladi 0.5 ~ 1.5 part; 0.05 ~ 0.3 part, Cinnabaris; Borneolum Syntheticum 0.05 ~ 0.4 part.The giddy that this invention causes cerebral blood supply insufficiency, dizzyly have rapid therapeutic effects, to middle-aged and old health and the slight sequela of cerebral hemorrhage all very useful, but its prescription biases toward the disease that old people causes due to cerebral ischemia, for symptom more single.
And, have quite a few Patients with Cardiovascular/Cerebrovascular Diseases not to be single disease at present, but various disease conditions exist simultaneously.If suffer from hypertension, hyperlipidemia or hyperglycemia simultaneously.And if the medicine of the just single symptom of market supply, multi-medicament to be taken for the patient suffering from the various disease conditions such as hypertension, hyperglycemia, hyperlipidemia simultaneously simultaneously, inconvenience is brought to patient, some medicine also also exists drug effect can not be lasting, have a rebound after drug withdrawal, the shortcoming that must uninterruptedly take for a long time.Meanwhile, due to the complex genesis of cardiovascular and cerebrovascular disease, at present its pathogeny and therapy mechanism still not very clear, these problems affect the curative effect of medicine, increase financial burden to patient.Therefore need to play the advantage of Chinese medicine, develop that too many levels, multi-level, many effects, toxic and side effects are little, the Chinese patent medicine of short treating period, evident in efficacy, low cost.
Summary of the invention
The invention provides a kind of effective fast, act on strong, many effects, with low cost, safe and reliable, toxic and side effects is little, Chinese medicine composition of preparation simple treatment cardiovascular and cerebrovascular disease and preparation method thereof.
For reaching this object, the Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease of the present invention, is made up of following each group of crude drug by weight ratio: 3 ~ 10 parts, Flos Carthami, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts, 8 ~ 12 parts, the Radix Rehmanniae, Rhizoma Cimicifugae 8 ~ 15 parts, Semen Arecae 7 ~ 10 parts, 2 ~ 5 parts, Radix Glycyrrhizae, 8 ~ 12 parts, Radix Rehmanniae Preparata.
Preferably, the proportioning of described crude drug is: 6 parts, Flos Carthami, Radix Angelicae Sinensis 8 parts, Radix Notoginseng 7 parts, 10 parts, the Radix Rehmanniae, Rhizoma Cimicifugae 11 parts, Semen Arecae 8 parts, 3 parts, Radix Glycyrrhizae, 10 parts, Radix Rehmanniae Preparata.
1) further preferably, described Chinese medicine composition makes pill, capsule, tablet, electuary.
The invention also discloses a kind of method preparing treatment cardiovascular and cerebrovascular disease Chinese medicine composition, comprise the following steps:
1) preparation of crude drug unsawn timber: each group of crude drug choosing described weight portion, washes clean and dries;
2) each group of crude drug is blended together co-ground to being less than 200 object fine powders;
3) by step 2) fine powder of gained adds in 65 ~ 85% ethanol and soaks 2 ~ 3 hours, be then placed in high temperature pot fry to water content be 5 ~ 10%;
4) medicine step 3) being done stir-fry concentrates makes pill, capsule, tablet, electuary, rear package encapsulation.
Each raw material in Chinese medicine composition of the present invention has following character and effect:
Flos Carthami: vessel softening, loose blood, the change blood stasis function of invigorating blood circulation of enriching blood.
Rhizoma Cimicifugae: can to blood vessel removing heat from blood, remove blood vessel virus, make health obtain promoting the production of body fluid active, promote body immunity.
Radix Notoginseng: there is the raw double effects beating ripe benefit, life promoting blood circulation and hemostasis, dissipating blood stasis for subsidence of swelling, resisting fatigue, anoxia enduring, anti-sorrow always, blood sugar lowering, ripe have blood-enriching qi-invigorating, raising body immune function.Cure mainly coronary heart diseases and angina pectoris, dizzy bitterly dizzy, coronary heart disease merging hypercalcinuria.
Radix Angelicae Sinensis: enrich blood invigorate blood circulation, the effect of blood pressure lowering, blood is accelerated active, blood vessel obtains expansion and blood pressure lowering with the effect of vessel softening, and make vascular occlusion obtain circulating, removing level and smooth spasm, more fresh blood is supplied.
Semen Arecae: promoting QI to circulate and dispersing the agglomeration of the pathogens, has very great help to sclerosis of blood vessels, can soften vascular occlusion, blood stasis.Help blood metabolism, run and play good result.
The Radix Rehmanniae: heat-clearing and toxic substances removing, can remove rapidly the noxious substance in blood and peroxide, alleviate vascular resistance.Recover blood vessel elasticity, increase myocardial viability effect.
Radix Rehmanniae Preparata: enrich blood comparatively strong, because sclerosis of blood vessels is serious, human body, for a long time all among being critically ill, so must accelerate to enrich blood, impelling human body native blood vessel to circulate and obtains metabolism.
The primary efficacy of above-mentioned Chinese medicine ingredients:
One, thrombolytic, fat eliminating, toxin expelling
The active matter mass-energy full activation heart and brain cytoactive of preparation, gets through the barrier of cardiovascular and cerebrovascular vessel, thrombus, removes blood fat, gets rid of the toxin in blood, increases heart and brain nutritional blood flow amount, recovers heart and brain circulatory function.
Two, clean blood, enrich blood, ventilate
Active matter mass-energy in preparation purifies the blood, removes blood rubbish, reduces cholesterol and glyceride, and reinforcing the heart brain alive, repaiies nerve, strengthen hemopoietic function, promoting QI to circulate and dispersing the agglomeration of the pathogens, increase cardiovascular and cerebrovascular vessel oxygen, make every biochemical indicator in blood function return to normal range.The three-hypers disease of hypertension, hyperlipidemia, hyperglycemia is improved comprehensively.
Three, vessel softening, loosening bowel to relieve constipation digestion promoting Systemic absorption, promotes body immunity
Active substance in preparation has promotion and softens and blood vessel dilating, and increase blood vessel elasticity, the effect reduced blood pressure, has loosening bowel to relieve constipation simultaneously, hard masses softening and resolving, moistens intestinal and leads to and dredging vascellum passage, promotion food absorption, improve the effect of body immunity.
Detailed description of the invention
Below in conjunction with embodiment, Chinese medicine composition of the present invention and preparation method thereof is described in further detail.
Formula one:
Chinese medicine composition is made up of following raw material medicaments: 3 grams, Flos Carthami, Radix Angelicae Sinensis 5 grams, Radix Notoginseng 4 grams, 8 grams, the Radix Rehmanniae, Rhizoma Cimicifugae 8 grams, Semen Arecae 7 grams, 2 grams, Radix Glycyrrhizae, 8 grams, Radix Rehmanniae Preparata.
The preparation method of this group Chinese medicine composition is:
1) preparation of crude drug unsawn timber: each group of crude drug choosing described weight portion, washes clean and dries;
2) each group of crude drug is blended together jointly grinds into powder to being not more than 200 object fine powders;
3) by step 2) fine powder of gained adds in 65 ~ 85% ethanol and soaks 2 ~ 3 hours, be then placed in high temperature pot fry to water content be 5 ~ 10%;
4) medicine step 3) being done stir-fry concentrates makes pill, capsule, tablet, electuary, rear package encapsulation.
Formula two:
Chinese medicine composition is made up of following raw material medicaments: 6 grams, Flos Carthami, Radix Angelicae Sinensis 8 grams, Radix Notoginseng 7 grams, 10 grams, the Radix Rehmanniae, Rhizoma Cimicifugae 11 grams, Semen Arecae 8 grams, 3 grams, Radix Glycyrrhizae, 10 grams, Radix Rehmanniae Preparata.
Formula three:
Chinese medicine composition is made up of following raw material medicaments: 10 grams, Flos Carthami, Radix Angelicae Sinensis 10 grams, Radix Notoginseng 10 grams, 12 grams, the Radix Rehmanniae, Rhizoma Cimicifugae 15 grams, Semen Arecae 10 grams, 5 grams, Radix Glycyrrhizae, 12 grams, Radix Rehmanniae Preparata.
The preparation method of formula two, three Chinese medicine composition and the preparation method of formula one similar, just no longer explain.
The beneficial effect of will be set forth the present invention by zoopery and clinical trial further and have below.
(1) present composition different ratio is on the impact of Mice intravascular coagulation time.
White mice coagulation time test adopts blood capillary tube method.The program is: get white mice 20, be divided into A at random, B, C, D tetra-groups, often organize 5, take out again 20 long for 20cm, internal diameter is the blood capillary of 1mm, 1 formula one pill is filled with to A group white mice according to dose, B group white mice fills with 1 formula two pill, C group white mice fills with 1 formula three pill, D group white mice is as a control group filled with and the normal saline of 1 pill with weight, after two hours, cut off the tail (general end 1cm place) of white mice, extrude 6 to bleed on sheet glass, immediately blood is sucked in blood capillary glass tubing, timing is started after horizontal positioned, fractureed every 30 seconds after two minutes the capillary tube of one section of 0.5cm, and slowly pull open to the left and right, whether the observation place of fractureing has blood clotting silk, to blood clotting silk occurs, institute's elapsed time is clotting time.The results are shown in Table 1.
Table 1. present composition different ratio is on the impact of Mice intravascular coagulation time
Shown by the result of table 1, compared with filling with the matched group D group white mice of normal saline, the clotting time of filling with A, B, C tri-groups of white mice of this invention Chinese medicine is obviously longer, extend more than 270S, simultaneously, also can find out that the white mice clotting time of B group is the longest, illustrate that the Chinese medicine of this invention extends the clotting time of white mice significantly, formula two is obviously better than formula one, formula three.
(2) present composition different ratio impact that rat thrombus in vivo is formed.
Scheme is: with scales/electronic balance weighing and record after silk thread normal saline of performing the operation soaks, penetrated by silk thread in polyethylene tube, two ends respectively stay 5 centimetres, and pour into 80u/ml heparin, make intubate for subsequent use.The rat 20 of then taking out 200 ~ 250 grams is divided into A, B, C, D tetra-groups at random, often organizes 5.1 formula one pill is filled with to A group white mice according to dose, B group white mice fills with 1 formula two pill, C group white mice fills with 1 formula three pill, and D group white mice is as a control group filled with and the normal saline of 1 pill with weight, with the chloralose intraperitoneal injection of anesthesia of 14.5% after perfusion.Then be separated rat side common carotid artery and external jugular vein, note external the end of a thread, and keep bulldog clamp closed condition.Until gavage after 2 hours, one end of common carotid artery jacket pipes operation silk thread, the other end of external jugular vein catcher art silk thread, opens bulldog clamp after having connect, allows blood naturally flow through intubate, form arteriovenous shunt, after 15 minutes, folder closes common carotid artery, rapidly takes out silk thread in intubate and allows blood clot, blotting rear scales/electronic balance weighing, deduct silk thread weight in wet base, be wet weight of thrombus.The results are shown in Table 2.
Table 2. present composition different ratio is on impact thrombotic in Mice
Shown by the result of table 1, compared with filling with the matched group D group white mice of normal saline, A, B, C tri-groups of white mice thrombus weights of filling with this invention Chinese medicine obviously alleviate, illustrate that the formation of the Chinese medicine of this invention to white mice thrombus in vivo has obvious inhibitory action, and formula two is obviously better than formula one, formula three.
Adopt Patients with Cardiovascular/Cerebrovascular Diseases 300 many cases such as treating coronary disease with traditional Chinese medicine of the present invention, cerebral thrombosis and hypertension, the patient outcomes of more than 98% is remarkable, below by partial clinical case, further illustrates the beneficial effect of Chinese medicine composition of the present invention.
Case 1:
Week so-and-so,, 55 years old, before starting from 2008, there is nervous uncomfortable in chest, power leakage in running in man, when doing taskwork, symptom is more obvious, often uncomfortable in chestly in bed to feel bad, can not lie low, often with tic of the limbs, once Multiple Hospitalization, symptom after taking medicine improves, but stopping taking medicine rear symptom occurs again, must prolonged administration of drugs.Throw at the beginning of 2012 (course for the treatment of of every day) after 7 courses for the treatment of of Chinese medicine composition of this invention, angina pectoris alleviates greatly, and symptom is very significantly improved, and continues drug administration and disappears and drug withdrawal completely to symptom, follow up a case by regular visits to half a year, have no recurrence.
Case 2:
Chen, man, 44 years old, often occur dizziness, realized that brothers were dumb, numb limbs and tense tendons before 2 years, effort of speaking, pronounces indistinctly.The inspections such as brain CT are done by Zeng Qu hospital, clinical diagnosis is the cardiovascular and cerebrovascular disease of QI and blood silt resistance, cerebral infarction, take Chinese medicine composition 5 of the present invention to paste rear (every day one pastes decoction), language is substantially smooth, and limbs are still numb, after continuing to take 3 subsides, brothers become relatively more flexible, then after taking 3 subsides, freedom of movement, continue drug administration to disappear completely to symptom, in 1 year, have no recurrence.
Above embodiment is only unrestricted for illustration of technical scheme of the present invention, illustrates that the Chinese medicine composition of this invention has significant beneficial effect in cardiovascular and cerebrovascular disease.
Claims (2)
1. treat a Chinese medicine composition for cardiovascular and cerebrovascular disease, it is characterized in that being made up of following each group of crude drug by weight ratio: 3 ~ 10 parts, Flos Carthami, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts, 8 ~ 12 parts, the Radix Rehmanniae, Rhizoma Cimicifugae 8 ~ 15 parts, Semen Arecae 7 ~ 10 parts, 2 ~ 5 parts, Radix Glycyrrhizae, 8 ~ 12 parts, Radix Rehmanniae Preparata.
2. the Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease according to claim 1, is characterized in that: the weight of described crude drug is: 6 parts, Flos Carthami, Radix Angelicae Sinensis 8 parts, Radix Notoginseng 7 parts, 10 parts, the Radix Rehmanniae, Rhizoma Cimicifugae 11 parts, Semen Arecae 8 parts, 3 parts, Radix Glycyrrhizae, 10 parts, Radix Rehmanniae Preparata.
3
.the Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease according to claim 1, is characterized in that: described Chinese medicine composition makes pill, capsule, tablet, electuary.
4
.prepare a method for treatment cardiovascular and cerebrovascular disease Chinese medicine composition as claimed in claim 1, it is characterized in that comprising the following steps:
1) preparation of crude drug unsawn timber: each group of crude drug choosing described weight portion, washes clean and dries;
2) each group of crude drug is blended together grinds to form fine powder;
3) fine powder being joined concentration is soak 2 ~ 3 hours in the ethanol of 65 ~ 85%, and being then placed in stir-fry to water content in high temperature pot is 5 ~ 10%;
4) medicine after fried dry is made pill, capsule, tablet, electuary, and package encapsulation.
5
.preparation method according to claim 4, is characterized in that: described in grind to form the degree of fine powder for being less than 200 orders.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1175461A (en) * | 1997-10-01 | 1998-03-11 | 黄治源 | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
| CN1507906A (en) * | 2002-12-19 | 2004-06-30 | 王德茂 | Medicine for treating cardio-cerebro vascular disease and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1175461A (en) * | 1997-10-01 | 1998-03-11 | 黄治源 | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
| CN1507906A (en) * | 2002-12-19 | 2004-06-30 | 王德茂 | Medicine for treating cardio-cerebro vascular disease and preparing method thereof |
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