CN1507906A - Medicine for treating cardio-cerebro vascular disease and preparing method thereof - Google Patents

Medicine for treating cardio-cerebro vascular disease and preparing method thereof Download PDF

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CN1507906A
CN1507906A CNA021566860A CN02156686A CN1507906A CN 1507906 A CN1507906 A CN 1507906A CN A021566860 A CNA021566860 A CN A021566860A CN 02156686 A CN02156686 A CN 02156686A CN 1507906 A CN1507906 A CN 1507906A
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radix
medicine
fructus
powder
tritici levis
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王德茂
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Abstract

The present invention relates to a Chinese medicine oral preparation for curing cardio-cerebral vascular diseases, such as myocardial ischemia, myocardiac infarction and cerebral infarction, its effectual rate is above 75% and total effective rate is 96.6%. Said oral preparation is made up by using 20 Chinese medicinal materials of astragatus root, pilose asiabell root, adenophora/glehnia root, schisandra berry, lycium berry, cuscuta seed, poria and other. Said invention also provides its preparation method.

Description

A kind of medicine and preparation method for the treatment of cardiovascular and cerebrovascular disease
Technical field
The present invention is a kind of herbal mixture, and exactly it is a kind of Chinese medicine and preparation method for the treatment of cardiovascular and cerebrovascular disease.
Background technology
Cardiovascular and cerebrovascular disease is a modal frequently-occurring disease in the serious threat human health, its sickness rate, prevalence, disability rate is all very high, according to World Health Organization (WHO), the mortality rate of cardiovascular and cerebrovascular disease accounts for the No. 1 in the world, so countries in the world medicine experts and scholars, all from different perspectives, different field goes to study the efficient of control cardiovascular and cerebrovascular disease, the medicine of low toxicity, as the Western medicine of present medical institutions at these cardiovascular and cerebrovascular diseases uses, the medicine such as the nitrate compound of treatment coronary heart disease, beta-blocker and calcium antagonist, but these Western medicine can only temporarily be eliminated symptom (taking stopgap measures), can not effect a radical cure the cause of disease (effecting a permanent cure), and certain toxic and side effects is arranged, and the Chinese patent medicine such as the GUIPI TANG (ball) of the Chinese medicine of China treatment cardiovascular and cerebrovascular disease, DAHUOLUO DAN, restorative bolus with tremendous power, NIAOXUEKANG and Ginkgo oral liquid etc., because clinical application effect is slow, fail to receive better curative effect, be the described myocardial infarction of modern medicine particularly at tcm clinical practice described " obstruction of heart-QI disease ", myocardial ischemia, " thoracic obstruction disease " is referred to as coronary heart disease, also has atherosclerosis, cerebral infarction, its reason all is because due to the illness that microcirculation disturbance brought, and more lacks medicable symptomatic drugs.
In order to give full play to the advantage of motherland's traditional plant pharmacy, utilize the rational formula and the processing technique of Chinese medicine, adopt the modern production technology method, produce active drug efficient, low toxicity.Therefore, seeking the active remedy of the new treatment " obstruction of heart-QI " " thoracic obstruction " of research, is the key subjects of being engaged in the Chinese medicine researcher, also is the key subjects that improve the human quality of the Chinese nation.
Summary of the invention
In order to address the above problem, the inventor is through tcm clinical practice practical exploration research decades, it is rapid to the present invention seeks to develop a kind of onset, efficacy stability, have no side effect, meet motherland's traditional medicine, meet the active drug that improves microcirculation in human body of blood circulation promoting and blood stasis dispelling, supplementing QI and nourishing YIN, the dredge the meridian passage rule of treatment, reach the compound oral Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease.
The present invention is achieved by the following technical solutions, a kind of medicine for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that it is by the Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), Fructus Schisandrae Chinensis, Fructus Lycii, field dobber, Poria, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Asparagi, Radix Ophiopogonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Tritici Levis, Stigma Croci, cornu saigae tatariace powder, Margarita powder and Radix Notoginseng powder are formed, the weight ratio of its prescription is: the Radix Astragali, Poria, Rhizoma Dioscoreae, the Radix Paeoniae Alba 100 ~ 60 grams, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), the Radix Rehmanniae, Radix Rehmanniae Preparata 60 ~ 45 grams, Fructus Schisandrae Chinensis, Fructus Lycii, field dobber, Radix Asparagi, Radix Ophiopogonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Stigma Croci, cornu saigae tatariace powder, Margarita powder, Radix Notoginseng powder 30 ~ 15 grams, boil through decocting, extraction separation, make oral medicine, the preparation method that contains this recipe drug, it is characterized in that (1) the yin-nourishing drug Radix Rehmanniae of enriching blood, Radix Rehmanniae Preparata, Radix Asparagi, Radix Ophiopogonis, Stigma Croci adds 3 ~ 4 times of water gagings, decoct 2 ~ 4 times with " slow fire ", each 10 ~ 30 minutes, decocting liquid filtered standby (A liquid); (2) regulating QI and promoting blood circulation to remove blood stasis medicine Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Fructus Lycii, field dobber add 3 ~ 4 times of water gagings, decoct 3 ~ 4 times with " intense fire ", and each 15 ~ 30 minutes, decocting liquid filtered standby (B liquid); (3) Radix Notoginseng, Margarita powder, cornu saigae tatariace powder are crushed to fine powder, prepare in the prescription ratio; (4) Radix Astragali, Radix Adenophorae (Radix Glehniae), Radix Codonopsis decocting are 30 ~ 40 minutes, and decocting liquid is concocted the back Fructus Tritici Levis with fermentation and mixed normal temperature fermentation after 3 ~ 6 days, filter and remove residue, taking liquid standby (C liquid); (5) process of preparing Chinese medicine of Fructus Tritici Levis is characterized in that adopting watered milk to mix with Fructus Tritici Levis under the room temperature after fermentation is concocted 3 ~ 4 days, removes liquid, stays its Fructus Tritici Levis standby; (6) behind each position decocting liquid and the concentrated solution uniform mixing, add the powder in the prescription, all, make granule, the various oral peroral dosage forms that are easy to absorption of human body such as oral liquid according to the method for oral preparation of Chinese traditional medicinal.As make oral liquid (be called temporarily and open XINTONGKOU PIAN), and make every milliliter and contain and be equivalent to the primary dose oral liquid of 1 gram, obey twice every day, obey 5 milliliters at every turn, 1 ~ 2 hour stage of attack of patients acuity, get final product relief of symptoms, and serveing on 15 days is a course of treatment.
Beneficial effect of the present invention adopts the human body integral idea that disease executing controlled of debating of the traditional Chinese medical science, with mediator's yin-yang, supplementing QI and nourishing YIN, it is pleasant to regulate the flow of vital energy, dredge the meridian passage, blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood, mediation makes moist and is characteristics, treatment " thoracic obstruction disease " (described myocardial ischemia of modern medicine, myocardial infarction), the traditional Chinese medical science is thought, the healthy energy interior-deficiency, the inside and outside intrinsic factor that do not cause " thoracic obstruction disease " admittedly, " thoracic obstruction " belongs to deficiency in origin, mark is real, the double solid disease of deficiency and excess, " thoracic obstruction " is trouble based on the deficiency of vital energy with the blood deficiency, so with blood stasis due to qi deficiency is serial clinical manifestation, energy and blood of human body is deficient, for the function of five internal organs imbalance is to suffer from, especially with kidney and lung improving inspiration by invigorating kidney-QI and Xuan Fawei master, the made medicine of this prescription is on basis handed down from one's ancestors, energy and blood of human body is regulated in practice through the successive dynasties, promotes to have strengthened integrally-regulated function on the microcirculation basis.Use that the patient of our made oral liquid is the quickest to take oral liquid 1 ~ 1.5 hour, the painful remission of heart strand, after the acute myocardial infarction patient serve on three days, remission 70% ~ 80%, patients with acute cerebral infarction serve on 3 ~ 5 days, relief of symptoms greatly serve on two courses of treatment (30 days) functional symptoms and is recovered comprehensively.
Description of drawings:
Fig. 1 treats preparation, the processing schematic flow sheet of the medicine of cardiovascular and cerebrovascular disease
A. the yin-nourishing drug (A liquid) of enriching blood
B. vital energy regualting and blood circulation-promoting medicine (B liquid)
C. the Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae) decocting liquid (C liquid)
D.A, B, C liquid are made oral formulations with thin medicated powder mixing compatibility
The specific embodiment
The medicine of prescription of the present invention and preparation method, to consolidate the training source, admittedly the kidney qi of receiving, a surname sends out a lung qi, and the spleen invigorating nourishing the liver forms the mechanism of integrally-regulated " vital organs of the human body " QI and blood, and belong to deficiency in origin at " thoracic obstruction ", mark is real, the deficiency and excess solid characteristics of holding concurrently, and development is a kind of rapid-action, the medicine of function-stable, the treatment cardiovascular and cerebrovascular disease that has no side effect.Capable with handsome blood among its side with the Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae) inrigorating qi and promoting blood circulation YIN nourishing and QI supplementing, the effect of microcirculation improvement.Stigma Croci blood circulation and promoting silt tissue regeneration promoting is got through blood vessels, the Radix Notoginseng removing stasis to stop bleeding is alleviated coronary artery spasm, coronary blood flow increasing, reduce myocardial oxygen consumption, regulate the myocardial metabolism anticoagulant, blood fat reducing fluid viscosity and blood viscosity, arrhythmia, get Radix Asparagi, Radix Ophiopogonis, the Fructus Lycii nourishing YIN and benefiting blood, field dobber reinforcing the kidney and supporting YANG kidney tonifying, Poria, the Rhizoma Dioscoreae invigorating the spleen and replenishing QI, building up the spleen to supplement the lung, get the sweet gentle blood of Radix Angelicae Sinensis, promoting blood circulation and stopping pain, the hot temperature of Rhizoma Chuanxiong is invigorated blood circulation, the energy blood-activating and qi-promoting, the dissipating depression of QI pain relieving, be the gas medicine in the blood, have the effect of logical big QI and blood, more strengthen promoting blood circulation to remove blood stasis with the Radix Angelicae Sinensis compatibility, the effect of promoting the circulation of QI to relieve pain, get the cold blood yin fluid astringing that nourishes blood of holding back of Radix Paeoniae Alba acid, get reinforce the kidney improving inspiration by invigorating kidney-QI a surname of Fructus Schisandrae Chinensis and send out a lung qi, the Radix Rehmanniae, the Radix Rehmanniae Preparata nourishing blood to suppress the hyperactive liver, The liver and the kidney have a common source goes out vital essence, heart master fire, deficiency of YIN fire must be absurd, Margarita powder in addition, cornu saigae tatariace powder, Fructus Tritici Levis, heat clearing away, removing heat from blood, spasmolytic, make asthenic fire from going out the molten meeting of QI and blood, the not absurd row of blood, prove effective in full side, it is integrally-regulated to form unification, consolidates the training source, supplementing QI and nourishing YIN, it is pleasant to regulate the flow of vital energy, blood circulation promoting and blood stasis dispelling, the blood vessels smoothness, dredge the meridian passage, modern pharmacology studies show that, Qi-tonifying drug mainly stresses to improve the hemodynamics of patients with coronary heart disease, improve cardiac function and anticoagulant, the Radix Astragali in this prescription, Radix Codonopsis, Radix Adenophorae (Radix Glehniae) preparation is used, and the enhancing myocardial contraction is not only arranged, protect a coronary artery, improve blood supply of cardiac muscle and myocardial metabolism, also have the lifting blood pressure, blood viscosity lowering and improve functions such as unusual hemorheology index, Radix Codonopsis has the expansion peripheral blood vessel, thereby bring high blood pressure down, and can improve heart pump blood volume, make brain, the effect of lower limb and SBF increase.The preparation method that contains this magistral medicines is abideed by tradition processing processing procedure, makes oral formulations according to the pharmacy codes and standards of Chinese Pharmacopoeia simultaneously.The processing of this medicine is adopted to divide and is fried in shallow oil the back merging, Fructus Tritici Levis is after watered milk is concocted, get mother solution again with after the Radix Astragali, Radix Codonopsis, the fermentation of Radix Adenophorae (Radix Glehniae) decocting liquid, merge with other minute decocting liquid merging and thin medicated powder, the method for going to produce oral formulations by the oral preparation of Chinese traditional medicinal standard behind the mixing is produced its product.
Using oral liquid that medicine of the present invention and processing method make below in conjunction with clinical case, to be called " opening XINTONGKOU PIAN " case summary temporarily as follows:
Clinical criteria; Employing traditional Chinese and western medicine diagnostic criteria and obstruction of qi in the chest weight divide into groups standard all with reference to middle specified standard of " guideline of clinical investigations of the new Chinese medicine treatment obstruction of qi in the chest (coronary disease and angina pectoris) " abbreviation (guideline) of bureau of drug administration of Ministry of Public Health formulation in 1993, and syndrome of qi deficiency and Blood stasis are studied international conference has the deficiency of vital energy and blood stasis in December, 1988 in " the Blood stasis diagnosis normative reference " of Beijing formulation main syndromes in " traditional Chinese medicine deficiency-syndrome normative reference " that Chinese medical discrimination reference (guideline) and national combination of Chinese tradiational and Western medicine asthenic symptoms and in May, the 1986 Zhengzhou meeting of disease of old people research Professional Committee are revised.
Myocardial ischemia is observed in treatment, myocardial infarction, and cerebral infarction, coronary heart disease, atherosclerosis amount to 220 examples, myocardial ischemia 84 examples, myocardial infarction 3 examples, cerebral infarction 3 examples, coronary heart disease 70 examples, atherosclerosis, three-hypers disease 60 examples.
Grouping: myocardial ischemia male 40 examples, women's 44 examples, 70 ~ 55 years old 46 example, 50 ~ 40 years old 38 example, the course of disease is the longest 5 years, and is the shortest 1 year half.Myocardial infarction male's 6 examples, cerebral infarction male 3 examples.Coronary heart disease male's 40 examples, women's 30 examples, the course of disease is the longest 12 years, and is the shortest 1 year.Arteriosclerosis three-hypers disease man 38 examples, women 22 examples, the course of disease is the longest 15 years, and is the shortest 4 years.
Therapeutic Method is taken and is opened during the XINTONGKOU PIAN, withdraw hit, Western medicine.At any time record check patient's heart rate, blood pressure, pulse frequency, angina pectoris attacks degree frequency, conventional 12 different electrocardiograms (doing ambulatory electrocardiogram and bicycle exercise test in case of necessity), mensuration hematuria routine, hepatic and renal function, blood fat, observe the change of traditional Chinese medical science tongue fur, pulse condition and syndrome, observe untoward reaction.
Instructions about how to take medicine: obey twice every day, each 5ml (five gram crude drug amounts), acute attack stage got final product relief of symptoms in 1 ~ 2 hour, and general patient 15 days was a course of treatment.
Criterion of therapeutical effect: angina pectoris, electrocardiogram is by the standard of working out in (guideline).Measurement datas such as blood fat are checked with t; The premature beat criterion of therapeutical effect is with reference to national therapy of combining Chinese and Western medicine angina pectoris in 1979 and arrhythmia forum revision " arrhythmia efficacy assessment standard "; Tcm syndrome is shaped on " tcm syndrome weight hierarchical table ", light, in, with (+), (++), (+++), (++ ++) expression, no person is (one) respectively for heavier, severe.
Therapeutic outcome: 220 routine obstruction of heart-QI diseases, thoracic obstruction disease patient, all patient's medications all through detections such as hepatic and renal function, blood, routine urinalysis, platelet and electrocardiograms, there is no abnormal change during 1 course of treatment, illustrate that opening XINTONGKOU PIAN is a kind of safe preparation.Modern medicine is a myocardial ischemia, myocardial infarction, arrhythmia, cerebral infarction, arteriosclerosis, the treatment of microcirculation disturbance is observed, and determined curative effect, obvious effective rate are 75%, total effective rate is 96.6% especially to myocardial ischemia, myocardial strain, and arteriosclerosis, cerebral infarction patient's cure rate is better.
Model case is introduced: the king * *, the man 65 years old, makes a definite diagnosis coronary heart disease, sclerosis of blood vessels, the long-term 180 ~ 110mmHg of hypertension, take this medicine and open XINTONGKOU PIAN, every day 2 times, each 5ml serve on two months (60 days), coronary heart disease symptom disappears, blood pressure stabilization is between 135 ~ 100mmHg, and blood fat is reduced to normal range, and body movement freely.
High * *, the man, 44 years old, myocardial hypertrophy, front and back chest angor, three-hypers disease, clinical definite is a coronary heart disease, takes and opens XINTONGKOU PIAN sx after 20 minutes, serve on three days symptoms and alleviates greatly, serve on 15 days symptoms and disappears substantially.
Fan * *, the man, 71 years old, cerebral embolism, three-hypers disease, facial facial hemiparalysis, liquid saliva, clothes opened XINTONGKOU PIAN every day 2 times, each 5ml, serve on three days after symptom take a turn for the better, symptom is recovered normally substantially after 20 days, after again steadiness take the disease elimination course of treatment.
Poplar * *, the man, 3 years old, heart malformations, tetra logy, livid purple, the frequent tic of the corners of the mouth serve on and opened XINTONGKOU PIAN 5 months, and disease all disappears, and it is fine to take care of oneself.
Use this recipe drug and prevent that the cardiac muscle stalk from taking place, regulate microcirculation, vessel softening shows unique characteristics.

Claims (4)

1. medicine for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that it is made up of the Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), Fructus Schisandrae Chinensis, Fructus Lycii, field dobber, Poria, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Asparagi, Radix Ophiopogonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Fructus Tritici Levis, Stigma Croci, cornu saigae tatariace powder, Margarita powder and Radix Notoginseng powder, the weight ratio of its prescription is the Radix Astragali, Poria, Rhizoma Dioscoreae, the Radix Paeoniae Alba 100 ~ 60 grams, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), the Radix Rehmanniae, Radix Rehmanniae Preparata 60 ~ 45 grams, Fructus Schisandrae Chinensis, Fructus Lycii, field dobber, Radix Asparagi, Radix Ophiopogonis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Stigma Croci, cornu saigae tatariace powder, Margarita powder, Radix Notoginseng powder 30 ~ 15 grams.Make oral drugs through decocting extraction separation.
2. the preparation method of the medicine of a treatment cardiovascular and cerebrovascular disease as claimed in claim 1 is characterized in that (1) enrich blood the yin-nourishing drug Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Asparagi, Radix Ophiopogonis, Stigma Croci, adds 3 ~ 4 times of water gagings, boils 2 ~ 4 times each 10 ~ 30 minutes with the slow fire decocting; (2) regulating QI and promoting blood circulation to remove blood stasis medicine, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Fructus Lycii, field dobber add 3 ~ 4 times of water gagings, decoct each 15 ~ 30 minutes with high heat 3 ~ 4 times; (3) Radix Notoginseng, Margarita powder, cornu saigae tatariace powder are ground into fine powder, prepare in the prescription ratio; (4) Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), decocting 30 ~ 40 minutes, decocting liquid mix normal temperature fermentation, and to get mother solution after 3 ~ 6 days standby with Fructus Tritici Levis; (5) Fructus Tritici Levis adopts milk and Fructus Tritici Levis fermentation process of preparing Chinese medicine back standby; (6) behind each position decocting liquid and the concentrated solution uniform mixing, make various oral drugs by Chinese medicine conventional formulation method, as oral liquid, granule etc.
3. according to the medicine and the preparation method of claim 1 and 2 described treatment cardiovascular and cerebrovascular diseases, wherein Fructus Tritici Levis is after concocting and use, it is characterized in that Fructus Tritici Levis employing watered milk liquid and Fructus Tritici Levis centrifugal treating after fermenting 3 ~ 4 days at normal temperatures, get the solid Fructus Tritici Levis and be Fructus Tritici Levis in the prescription.
4. according to the medicine and the preparation method of claim 1 and 2 described treatment cardiovascular and cerebrovascular diseases, it is characterized in that to make the oral formulations of the demonstration physiologically active that is easy to oral absorption.
CNA021566860A 2002-12-19 2002-12-19 Medicine for treating cardio-cerebro vascular disease and preparing method thereof Pending CN1507906A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103251764A (en) * 2013-05-21 2013-08-21 温业林 Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof
CN106237066A (en) * 2016-08-25 2016-12-21 西安必康制药集团有限公司 A kind of medicine of supporing yang QI invigorating and yin nourishing and preparation method thereof
CN107812102A (en) * 2017-12-26 2018-03-20 李树月 A kind of pharmaceutical composition for treating cardiovascular and cerebrovascular disease and preparation method thereof, preparation and application
CN108452074A (en) * 2018-05-16 2018-08-28 刘朝顺 Improve myocardial ischemia, the herbal cuisine composition of blood supply insufficiency and scattered decoction preparation method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103251764A (en) * 2013-05-21 2013-08-21 温业林 Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof
CN103251764B (en) * 2013-05-21 2015-08-26 温业林 A kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof
CN106237066A (en) * 2016-08-25 2016-12-21 西安必康制药集团有限公司 A kind of medicine of supporing yang QI invigorating and yin nourishing and preparation method thereof
CN107812102A (en) * 2017-12-26 2018-03-20 李树月 A kind of pharmaceutical composition for treating cardiovascular and cerebrovascular disease and preparation method thereof, preparation and application
CN108452074A (en) * 2018-05-16 2018-08-28 刘朝顺 Improve myocardial ischemia, the herbal cuisine composition of blood supply insufficiency and scattered decoction preparation method

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