CN102397391A - Drug for treating hypertension, hyperlipaemia and blood hyperviscosity and preparation method thereof - Google Patents

Abstract

The invention relates to a drug for treating hypertension, hyperlipaemia and blood hyperviscosity and a preparation method thereof. The medicine for treating hypertension, hyperlipaemia and blood hyperviscosity and preparation method thereof comprises the following raw materials in part by weight: 10 to 20 Salvia miltiorrhiza, 5 to 10 bark of tree peony root, 1 to 3 leech, 15 to 25 self-heal, 3 to 6 Chinese thorowax, 9 to 12 dried rhizome of rehmannia, 3 to 6 dried orange peel, 3 to 9 Magnolia officinalis, 3 to 9 Cocculus diversifolius Miq. and 6 to 12 hawthorn. Combined with needle therapy, compared with the prior art adopting western medicine to treat the hypertension, hyperlipaermia and the blood hyperviscosity, the method has advantages that the treatment efficiency is remarkable, the action is durable and stable, and no toxicity and side effect exists.

Description

Medicine of treatment hypertension, hyperlipidemia, high blood viscosity and preparation method thereof

Technical field

The present invention relates to medicine that cooperates acupuncture and moxibustion treatment treatment hypertension, hyperlipidemia, high blood viscosity and preparation method thereof.

Background technology

Diseases of cardiovascular and cerebrovascular systems such as hypertension, hyperlipidemia, high blood viscosity are a kind of commonly encountered diseases, frequently-occurring disease, also are a kind of mortality rate disease with high.The induced factor of this type disease as a rule, shows as that blood fat height, blood stickiness increase, blood flowing speed slows down, and influences the normal circulation of blood, thereby causes the generation of vascular system disease.

Along with understanding and the raising of modern medicine to acupuncture, acupuncture is of common occurrence clinically in the treatment that reduces cardiovascular and cerebrovascular diseases such as hypertension, have plenty of temporary, have plenty of permanent, have to obtain effect very fast, the effectiveness that has is slow.Effective reason of acupuncture, present stage medical science can not provide satisfied answer.It is generally acknowledged: regulate and the control higher nervous activity, adjusting vascular pressure system punctures little blood vessel, makes blood pressure drops.But at present, also do not cooperate the Chinese herbal and crude drugs preparations of acupuncture and moxibustion treatment to be used to treat hypertension, hyperlipidemia, high blood viscosity.

Summary of the invention

The present invention proposes a kind of new solution to the problem that above-mentioned Therapeutic Method exists.It is raw material that the present invention selects the pure natural Chinese herbal medicine for use, be prepared into conveniently take, obtain and imitate preparation fast, that cooperate acupuncture and moxibustion therapy hypertension, hyperlipidemia, high blood viscosity.Dredge the meridian passage of the present invention, blood pressure lowering, blood fat reducing improve blood circulation.

Solution provided by the invention is:

The medicine of treatment hypertension, hyperlipidemia, high blood viscosity, form by the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 10 ~ 20, Cortex Moutan 5 ~ 10, Hirudo 1 ~ 3, Spica Prunellae 15 ~ 25, Radix Bupleuri 3 ~ 6, the Radix Rehmanniae 9 ~ 12, Pericarpium Citri Reticulatae 3 ~ 6, Cortex Magnoliae Officinalis 3 ~ 9, Radix Stephaniae Tetrandrae 3 ~ 9, Fructus Crataegi 6 ~ 12.

Concrete, the medicine of said treatment hypertension, hyperlipidemia, high blood viscosity, form by the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 14 ~ 17, Cortex Moutan 7 ~ 8, Hirudo 1.6 ~ 2.3, Spica Prunellae 18 ~ 22, Radix Bupleuri 4 ~ 5, the Radix Rehmanniae 10 ~ 11, Pericarpium Citri Reticulatae 4 ~ 5, Cortex Magnoliae Officinalis 5 ~ 7, Radix Stephaniae Tetrandrae 3 ~ 7, Fructus Crataegi 7 ~ 10.

Concrete, the medicine of said treatment hypertension, hyperlipidemia, high blood viscosity, form by the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 15, Cortex Moutan 7, Hirudo 2, Spica Prunellae 20, Radix Bupleuri 4.5, the Radix Rehmanniae 10, Pericarpium Citri Reticulatae 4.5, Cortex Magnoliae Officinalis 6, Radix Stephaniae Tetrandrae 5, Fructus Crataegi 9.

The method for preparing of treatment hypertension, hyperlipidemia, high blood viscosity medicine,

1) raw material of the following ratio of weight and number of preparation: Radix Salviae Miltiorrhizae 10 ~ 20, Cortex Moutan 5 ~ 10, Hirudo 1 ~ 3, Spica Prunellae 15 ~ 25, Radix Bupleuri 3 ~ 6, the Radix Rehmanniae 9 ~ 12, Pericarpium Citri Reticulatae 3 ~ 6, Cortex Magnoliae Officinalis 3 ~ 9, Radix Stephaniae Tetrandrae 3 ~ 9, Fructus Crataegi 6 ~ 12;

2) raw material of above-mentioned preparation adopts industrial making method to be processed into tablet, powder, decoction, honeyed pill or capsule.

Radix Salviae Miltiorrhizae, Cortex Moutan, Hirudo removing blood stasis, blood circulation promoting and blood stasis dispelling and repercussive blood; Removing heat from the liver to lower the high blood pressure, relieving restlessness are calmed the nerves, logical blood circulation regulating, blood vessel dilating; The alleviating vascular spasm; Improve the blood vessel endothelium cellulose content, the viscosity of blood fat reducing and blood can make blood-retention or long-pending stagnation resolvation loose and be absorbed in the blood circulation or from stool and gush and separate.

Spica Prunellae, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae nourshing blood and promoting blood circulation blood stasis dispelling and do not hinder fresh blood, depressed liver-energy dispersing and QI regulating, the promoting the circulation of blood resolving depression, removing heat from the liver to lower the high blood pressure is regulated unbalancely, leads the mechanism of qi operation of liver and gall off, and blood circulation promoting improves the nutritional status of blood, makes elevated blood pressure be able to descend.

The Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Radix Stephaniae Tetrandrae, Fructus Crataegi invigorating spleen to remove dampness, drying dampness to eliminate phlegm, diuretic heat clearing away; The burnt blood system turbid damp of diarrhea, the unusual rising of blood fat is alleviated in the adjustment metabolism; Improve the high sticky blood state, increase ED, negative and positive are gone up and down in order; QI and blood is transferred big, and phlegm-damp has outlet, and it is normal that three high targets are able to recover.

Take medicament provided by the invention, and following acupuncture point is applied acupuncture.Fenglong acupoint: straight thrust l～1.5 cun, 10 minutes hand-manipulating of needle are 1 time at interval.DAZHUI acupoint: 0.5-1 cun of straight thrust.Baihui acupoint: 0.5-0.8 cun of flat thorn.Tsu san li: diagonal stabbing is 0.8-1.5 cun backward.Neiguan acupoint: 0.5-1 cun of straight thrust.WEIYU acupoint: the side is opened 1.5 cun.The bl cave: the side is opened 1.5 cun.

DAZHUI acupoint, Baihui acupoint, Fenglong acupoint dredging the meridian, the QI and blood regulating rouses oneself human body, regulates brain function, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, the hard eliminating stagnation that disappears, inducing QI is descending, improves blood capillary circulation and blood pressure symptom.Fenglong acupoint, tsu san li, Neiguan acupoint warming the kidney and strengthening the spleen, the YANG invigorating QI invigorating, the clots absorbing of regulating the flow of vital energy, damp eliminating is reduced phlegm, and improves the human body metabolism, promotes gastrointestinal peristalsis and bile secretion or discharge effect, can lower unusual that blood fat and blood flow change.Baihui acupoint, nei guan point, WEIYU acupoint making the adverse-rising QI downwards, promoting blood circulation and removing blood stasis, nurse one's health all sun, the cleaning head; Negative and positive are played two-way optimum conditioning, reduce the plain level of blood vessel endothelium, and play hemangiectasis; Lower the peripheral resistance effect, promote immunity of organism, coordinate nerve-endocrine function.Bl cave, WEIYU acupoint rouse oneself stops up the QI and blood that stagnates in the QI and blood dredging the meridian, coordinate deficiency and excess, the dysfunction of conditioning viscera, each internal organs functional status of two-way optimum conditioning.

The present invention filters out blood circulation promoting and blood stasis dispelling, vessel softening; By the theory of Chinese medical science prescription, skim the cream off milk, give full play to blood fat reducing viscosity reduction, vessel softening, antidotal effect; Cooperate above-mentioned acupuncture and moxibustion treatment; Can heighten the effect of a treatment, slow down the development of hyperlipidemia, hypertension, high blood viscosity, avoid the untoward reaction of Western medicine.

Through medicine provided by the invention and combine the manipulation of acupuncture, adopt the pure Chinese medicine and the manipulation of acupuncture fully, greatly reduce the misery of patient in therapeutic process, and the toxic and side effects of having avoided the Western medicine medicine that the patient is produced.Because the price of Chinese medicine ingredients and the relative Western medicine of expense of the manipulation of acupuncture are cheap, have also further reduced the treatment cost, but also have reduced patient's sickness rate and disability rate.

The specific embodiment

The method for preparing of treatment hypertension, hyperlipidemia, high blood viscosity medicine,

1) raw material of the following ratio of weight and number of preparation: Radix Salviae Miltiorrhizae 15g, Cortex Moutan 7g, Hirudo 2g, Spica Prunellae 20g, Radix Bupleuri 4.5g, Radix Rehmanniae 10g, Pericarpium Citri Reticulatae 4.5g, Cortex Magnoliae Officinalis 6g, Radix Stephaniae Tetrandrae 5g, Fructus Crataegi 9g;

2) raw material that above-mentioned weight proportion is good adopts industrial making method to be processed into the decoction of taking in a day.

One day twice, one course of treatment of first quarter moon.

Take medicament provided by the invention, following acupuncture point is applied acupuncture.Fenglong acupoint: straight thrust l～1.5 cun, 10 minutes hand-manipulating of needle are 1 time at interval.DAZHUI acupoint: 0.5-1 cun of straight thrust.Baihui acupoint: 0.5-0.8 cun of flat thorn.Tsu san li: diagonal stabbing is 0.8-1.5 cun backward.Neiguan acupoint: 0.5-1 cun of straight thrust.WEIYU acupoint: the side is opened 1.5 cun.The bl cave: the side is opened 1.5 cun.

The inventor has carried out experimental observation to the curative effect of technical scheme of the present invention.Test situation is following: the human body normal arterial pressure be systolic pressure >=140mmHg with (or) diastolic pressure >=90mmHg, can be diagnosed as hypertension.Total plasma cholesterol 5.7mmol/L, plasma triglyceride, 2.0mmol/L can be diagnosed as hyperlipidemia.

It is following to adopt this medicament to combine acupuncture therapy to carry out the clinical treatment observation situation:

1, physical data:

Male 42 examples, women 58 examples in test group 100 examples, 35 ~ 83 years old age, average (56.3 ± 6.3) year, the course of disease 4.7 ~ 17.3 years, average (8.6 ± 3.9) year.Male 49 examples, women 51 examples in the matched group 1,33 ~ 81 years old age, average (55.6 ± 5.9) year, the course of disease 5.1 ~ 16.3 years, average (9.4 ± 5.0) year.Male 46 examples, women 54 examples in the matched group 2,31 ~ 81 years old age, average (54.6 ± 5.5) year, the course of disease 5.0 ~ 17.1 years, average (9.2 ± 4.3) year.

2, the new Chinese medicine clinical research guideline that study subject is selected, efficacy determination is all formulated according to state food and drug administration.

3, administrated method, dosage and observation item

Test group: adopt the said medicament of present embodiment.One day twice, one course of treatment of first quarter moon.Cooperate above-mentioned acupuncture-moxibustion therapy method.

Contrast 1 group: only use above-mentioned acupuncture-moxibustion therapy method.Once-a-day, course of treatment of first quarter moon.

Contrast 2 groups: take Nifedipine sustained release tablets.The adult recommends following dosage: a slice (30mg), 1 time on the one.Course of treatment of first quarter moon.

Observation item: 1) empty stomach serum total cholesterol and serum total cholesterol.2) blood pressure: METHOD FOR CONTINUOUS DETERMINATION is averaged for 3 times.

4, blood, urine, just respectively do once before and after three big routines and electrocardiogram, liver function, the renal function curing.Bad and toxic reaction after the observation medication.

5, result of the test

Test group 100 examples, the responder reaches 100 examples, and effective percentage is 100%.Contrast 1 group of 100 example, responder's 67 examples, effective percentage 67%.Contrast 2 group of 100 example, responder's 83 examples, effective percentage 83%.Explain that the comparison of test group total effective rate is high according to 2 groups.The comparison of test group total effective rate is high according to 1 group.The treatment means that contrasts 1 group can be played a role.

6, toxic and side effects

Do not see obvious toxic-side effects after the test group medication.Matched group has appearance for 2 groups: dizzy, feel sick, the patient of symptoms such as constipation, weak, flush.Matched group has no adverse reaction for 1 group.

Medicament of the present invention combines acupuncture and moxibustion treatment, with the existing method that adopts western medicine hypertension, hyperlipidemia, high blood viscosity, has the advantageous feature that curative effect is obvious, effect is continual and steady, have no side effect.

Claims (4)

1. the medicine of treatment hypertension, hyperlipidemia, high blood viscosity is characterized in that, is made up of the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 10 ~ 20, Cortex Moutan 5 ~ 10, Hirudo 1 ~ 3, Spica Prunellae 15 ~ 25, Radix Bupleuri 3 ~ 6, the Radix Rehmanniae 9 ~ 12, Pericarpium Citri Reticulatae 3 ~ 6, Cortex Magnoliae Officinalis 3 ~ 9, Radix Stephaniae Tetrandrae 3 ~ 9, Fructus Crataegi 6 ~ 12.

2. according to the medicine of the said treatment hypertension of claim 1, hyperlipidemia, high blood viscosity, it is characterized in that, form by the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 14 ~ 17, Cortex Moutan 7 ~ 8, Hirudo 1.6 ~ 2.3, Spica Prunellae 18 ~ 22, Radix Bupleuri 4 ~ 5, the Radix Rehmanniae 10 ~ 11, Pericarpium Citri Reticulatae 4 ~ 5, Cortex Magnoliae Officinalis 5 ~ 7, Radix Stephaniae Tetrandrae 3 ~ 7, Fructus Crataegi 7 ~ 10.

3. according to the medicine of the said treatment hypertension of claim 1, hyperlipidemia, high blood viscosity, it is characterized in that, form by the raw material of following ratio of weight and number:

Radix Salviae Miltiorrhizae 15, Cortex Moutan 7, Hirudo 2, Spica Prunellae 20, Radix Bupleuri 4.5, the Radix Rehmanniae 10, Pericarpium Citri Reticulatae 4.5, Cortex Magnoliae Officinalis 6, Radix Stephaniae Tetrandrae 5, Fructus Crataegi 9.

4. the method for preparing of treatment hypertension, hyperlipidemia, high blood viscosity medicine is characterized in that,

1) raw material of the following ratio of weight and number of preparation: Radix Salviae Miltiorrhizae 10 ~ 20, Cortex Moutan 5 ~ 10, Hirudo 1 ~ 3, Spica Prunellae 15 ~ 25, Radix Bupleuri 3 ~ 6, the Radix Rehmanniae 9 ~ 12, Pericarpium Citri Reticulatae 3 ~ 6, Cortex Magnoliae Officinalis 3 ~ 9, Radix Stephaniae Tetrandrae 3 ~ 9, Fructus Crataegi 6 ~ 12;

2) raw material of above-mentioned preparation adopts industrial making method to be processed into tablet, powder, decoction, honeyed pill or capsule.