CN103735741A - Traditional Chinese medicinal composition for treating gout - Google Patents
Traditional Chinese medicinal composition for treating gout Download PDFInfo
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- CN103735741A CN103735741A CN201410031934.1A CN201410031934A CN103735741A CN 103735741 A CN103735741 A CN 103735741A CN 201410031934 A CN201410031934 A CN 201410031934A CN 103735741 A CN103735741 A CN 103735741A
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating gout, and relates to the technical field of biomedicines. The traditional Chinese medicine is prepared by mixing the following raw materials in parts by weight: 40-55 parts of tea polysaccharide, 10-15 parts of cherry powder, 5-10 parts cherry powder, 5-10 parts of large-leaved gentian powder, 3-6 parts of camellia seed extract, 4-6 parts of angelica root powder, 10-15 parts of kudzuvine root powder, and 3-8 parts of radix cyathulae powder, wherein the camellia seed extract is prepared by mixing the following components in parts by weight: 50-70 parts of unsaturated fatty acid, 10-40 parts of squalene, and 1.5-3 parts of tea polyphenol. The traditional Chinese medicinal composition has the effects of clearing heat and dredging collaterals, diminishing edema and relieving pain, eliminating wind and dampness, clearing damp-heat, relieving pain, removing stasis and clearing channels, easing joint movement, strengthening body immunity and the like, is used for treating gout, and is suitable for patients with gout at different ages and different sexes.
Description
Technical field
The present invention relates to biological medicine technology field, particularly a kind of Chinese medicine composition for the treatment of goat.
Background technology
Gout is a kind of because biosynthesis of purine metabolism increase, uric acid produce too much or because uric acid in the bad hyperamization of urate excretion raises, urate crystal is deposited on the repeated relapsing inflammatory diseases causing in synovium of joint, synovial bursa cartilage and hetero-organization thereof.At present, for the treatment of gout, doctor trained in Western medicine mainly adopts the medicines such as colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen, piroxicam, naproxen and ACTH and prednisone, benemid (probenecid), sulphinpyrazone, benzbromarone, different purine alcohol.Chinese patent (number of patent application is 200810159269.9) " medicament for the treatment of gout ", it is to be comprised of, Semen Strychni (processed), Herba Asari, the Radix Angelicae Dahuricae, corydalis tuber, Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Cortex Acanthopancis, Radix Rehmanniae Preparata, Fructus Lycii, Herba Taxilli, Radix Clematidis, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Pheretima, Radix Notoginseng, Radix Angelicae Sinensis, Radix Saposhnikoviae, Olibanum, Myrrha, Sanguis Draxonis, Herba speranskiae tuberculatae, Radix Salviae Miltiorrhizae, Carapax et Plastrum Testudinis, Carapax Trionycis, Air Bladder pseudosciaenae seu Acipenser.Top also can add Radix Angelicae Pubescentis, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Preparata; Having and cold can add Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Colla cornus cervi, can add Agkistrodon, Herba Siegesbeckiae as weight in wet base; As pain very adds Scolopendra, Scorpio, Hirudo.Advantage of the present invention is, curative effect is showing, effective percentage 76%, and cure rate is more than 55%.And for example Chinese patent (number of patent application is 200510010521.6) " is treated pain, the tincture of anemofrigid-damp arthralgia ", it is pinke needle oil 5KG, Cortex Acanthopancis extracting solution 5KG, Herba Lycopodii, Radix Clematidis, Radix Gentianae Macrophyllae, Dioscorea nipponica Mak. Ningpo Yam Rhizome, Herba speranskiae tuberculatae, Radix Seu Caulis Celastri Flagellaris, Rhizoma Atractylodis, Radix Angelicae Pubescentis, Radix Inulae, Pericarpium Zanthoxyli, Rhizoma Anemones Raddeanae, Rhizoma Cyperi, Fructus Foeniculi, Herba Artemisiae Anomalae, Rhizoma Sparganii, Cortex Phellodendri, cnidium officinale makino, Flos Carthami, Rhizoma Gastrodiae, Pheretima, Radix Saposhnikoviae, Herba Ephedrae, the Radix Angelicae Dahuricae, Herba Menthae, Ramulus Mori, Semen Sinapis Albae, Cortex Dictamni, Ramulus Sambuci Williamsii, Cortex Sorbariae Arboreae, Herba Syneilesis Aconitifoliae, leontice robustumDiels, Herba Veronicastri Sibirici, the Fructus Kochiae, parasitism and each 1KG of Rhizoma Corydalis, Radix Aconiti Coreani, Rhizoma Arisaematis, Herba Typhonii gigantei, Fructus Xanthii, japanese angelica tree, Herba Siegesbeckiae, North Radix Aconiti Kusnezoffii, Eupolyphaga Seu Steleophaga, Spina Gleditsiae, Periostracum Serpentis, Semen Ricini, each 0.5KG of Nidus Vespae and Fructus Cnidii is at ethanol 95%50KG, in glucide 5ML and essence 5ML, soak the extracting solution obtaining for 2-3 month.Product of the present invention can be brought into play expelling wind and removing dampness, dispersing cold for relieving pain, activating blood circulation to dissipate blood stasis, stimulate the menstrual flow and adjust network, detumescence to separate the effect of disease.Also has Chinese patent (number of patent application is 201110027145.7) " a kind of Chinese medicine for the treatment of gout and preparation method thereof ", the raw material of making its effective ingredient forms percentage by weight and is: the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Cordyceps, Fructus Pruni pseudocerasi, Caulis Trachelospermi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 25-35, xylitol 20-30, implant 40-50; There is expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid quench one's thirst, invigorating QI to consolidate the body surface resistance, diuresis poison holding, enrich blood invigorate blood circulation, the effect such as the kidney warming is mended essence, benefiting QI and nourishing blood, invigorating the lung and the kidney, dissipating phlegm and removing blood stasis, expelling wind and removing dampness, numbness relieving and pain relieving, liver heat removing function of gallbladder promoting, dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence, can be used for treating multiple gout.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effects such as heat clearing away dredging collateral, reducing swelling and alleviating pain, expelling wind and removing dampness, clearing away damp-heat, stopping numbness pain, eliminating blood stasis and inducing menstruation, easing joint movement, enhancing human body immunity ability that have, and can treat the Chinese medicine composition of goat.
The technical solution used in the present invention is a kind of Chinese medicine composition for the treatment of goat of invention, is to be mixed by following raw material by weight:
Tea polysaccharide 40-55 cherry powder 10-15 Radix Gentianae Macrophyllae powder 5-10
Semen Camelliae extract 3-6 Radix Angelicae Dahuricae powder 4-6 powder of Radix Puerariae 10-15
Radix Cyathulae powder 3-8;
Described Semen Camelliae extract is to be mixed by following material by weight:
Unsaturated fatty acid 50-70 Squalene 25-40 tea polyphenols 1.5-3;
Wherein, in unsaturated fatty acid, the percentage by weight of each composition is:
Oleic acid 50-70 linoleic acid 10-20 linolenic acid 10-20.
Described cherry powder is pulverized the cherry powder of rear gained by cherry pulp, or is prepared from by following method:
A, enucleation: get fresh cherry, remove Semen Persicae, obtain Fructus Pruni pseudocerasi sarcocarp;
B, making beating: Fructus Pruni pseudocerasi sarcocarp is dropped in beater together with accounting for the clear water of Fructus Pruni pseudocerasi sarcocarp weight 30-50%, break into 40-80 object Fructus Pruni pseudocerasi juice;
C, alcohol soak: in Fructus Pruni pseudocerasi juice, add edible ethanol, limit edged stirs, and after being 60-80%, in temperature, are to soak 30-45min at 45-70 ℃ to the volumetric concentration of ethanol, cross 60-100 mesh sieve, respectively soak with ethanol liquid and Fructus Pruni pseudocerasi sarcocarp slag;
D, water extraction: the boiling water to adding 2-3 times of weight in Fructus Pruni pseudocerasi sarcocarp slag, stir evenly, standingly under normal pressure to water temperature, be down to 30-45 ℃, cross 100-140 mesh sieve, obtain Sucus pruni pseudocerasi extract;
E, Sucus pruni pseudocerasi extract concentrate: by Sucus pruni pseudocerasi extract, in vacuum, be that 0.6-0.8MPa, temperature are that in being concentrated into every 100ml liquid at 60-80 ℃, solid content is 5-8g, obtain Fructus Pruni pseudocerasi water extracting liquid;
F, soak with ethanol liquid concentrate: by soak with ethanol liquid, in vacuum, be that 0.35-0.65MPa, temperature are that in being concentrated into every 100ml concentrated solution at 50-70 ℃, solid content is 10-15g, obtain soak with ethanol concentrated solution;
G, powder process: by Fructus Pruni pseudocerasi water extracting liquid: the part by weight of soak with ethanol concentrated solution=1.5-2.5:1 mixes, then spraying is dry, obtains cherry powder.
Described Radix Angelicae Dahuricae powder is the Radix Angelicae Dahuricae powder of gained after being pulverized by the Radix Angelicae Dahuricae, or is prepared from by following method:
A, extraction: to adding 2-4 times of weight in the Radix Angelicae Dahuricae, by ethyl acetate: the solvent that 5% aqueous citric acid solution mixes by the part by weight of 3-4:1, at 50-75 ℃, extract 1-2h, cross 60-100 mesh sieve, respectively Radix Angelicae Dahuricae extracting solution and Radix Angelicae Dahuricae slag;
B, separation: extraction Radix Angelicae Dahuricae extracting solution is put into tank, after it is cooled to room temperature and stratification, collect ethyl acetate layer liquid;
C, the contracting of ethyl acetate layer dope: by ethyl acetate layer liquid, in vacuum, be that 0.3-0.45MPa, temperature are that in being concentrated into every 100ml liquid at 35-50 ℃, solid content is 6-10g, obtain ethyl acetate layer concentrated solution;
D, water extraction: to the clear water that adds 1.5-3 times of weight in Radix Angelicae Dahuricae slag, boil and extract 0.5-1.5h, cross 100-140 mesh sieve, obtain Radix Angelicae Dahuricae pulp water extract;
E, Radix Angelicae Dahuricae pulp water extract concentrate: by Radix Angelicae Dahuricae pulp water extract, in vacuum, be that 0.6-0.8MPa, temperature are at 60-80 ℃, to be concentrated into the 1/4-1/2 of original volume, obtain Radix Angelicae Dahuricae slag water extracting liquid;
F, powder process: by ethyl acetate layer concentrated solution: the part by weight of Radix Angelicae Dahuricae slag water extracting liquid=2-3:1 mixes, then spraying is dry, obtains Radix Angelicae Dahuricae powder.
Described Radix Cyathulae powder is the Radix Cyathulae powder of gained after being pulverized by Radix Cyathulae, or is prepared from by following method:
A, pulverizing: Radix Cyathulae is processed into 30-40 object Radix Cyathulae powder;
B, alcohol extraction: in Radix Cyathulae powder, add the edible ethanol that 1-2 times of weight, volumetric concentration are 70-90%, stir evenly, being dipped at normal temperatures and pressures solid content in every 100ml solution is 2.5-4.5g, cross 100-140 mesh sieve, obtains Radix Cyathulae soak with ethanol liquid;
C, powder process: by Radix Cyathulae soak with ethanol liquid, at 40-55 ℃, vacuum, be under 0.45-0.6MPa, to be concentrated into the 1/5-1/3 of original volume, then spraying is dry,, obtain Radix Cyathulae powder.
Described powder of Radix Puerariae is the powder of Radix Puerariae of gained after being pulverized by Radix Puerariae, or is prepared from by following method:
A, washing: Radix Puerariae is dropped in the water of 2-3 times of weight, boil and extract 25-40min, cross 60-100 mesh sieve, obtain respectively Radix Puerariae water extraction liquid and Radix Puerariae slag;
B, alcohol extraction: to dropping into the edible ethanol that 2-3 times of weight, volumetric concentration are 75-85% in Radix Puerariae slag, reflux, extract, 30-45min, filters, and obtains Radix Puerariae slag ethanol extract;
C, Radix Puerariae water extraction liquid concentrate: by Radix Puerariae water extraction liquid, in vacuum, be that 0.3-0.45MPa, temperature are that in being concentrated into every 100ml solution at 60-75 ℃, solid content is 4-8g, obtain Radix Puerariae water extracting liquid;
D, Radix Puerariae water extraction cream powdering: Radix Puerariae water extracting liquid is spray-dried, obtain water extraction powder of Radix Puerariae;
E, Radix Puerariae slag ethanol extract are concentrated: by Radix Puerariae slag ethanol extract, in vacuum, be that 0.4-0.6MPa, temperature are that at 40-50 ℃, to be concentrated into ethanol volumetric concentration be 40-50%, obtain Radix Puerariae slag ethanol extraction concentrated solution, add again the acidic alumina that accounts for Radix Puerariae slag ethanol extraction concentrated solution weight 10-15%, stir 15-20min, filter, obtain Radix Puerariae slag ethanol extraction concentrated solution;
F, Radix Puerariae slag ethanol extraction cream powdering: Radix Puerariae slag ethanol extraction concentrated solution is spray-dried, obtain alcohol extraction Radix Puerariae ground-slag;
G, mixing: by water extraction powder of Radix Puerariae: alcohol extraction Radix Puerariae ground-slag mixes according to the part by weight of 1:5-7, cross 80-120 mesh sieve, obtains powder of Radix Puerariae.
Described Radix Gentianae Macrophyllae powder is the Radix Gentianae Macrophyllae powder of gained after being pulverized by Radix Gentianae Macrophyllae, or is mixed by following material by weight:
Gentianol 24-40 Radix Gentianae Macrophyllae erythricine 50-65 Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 2-5.
The technical scheme of its optimization is to be mixed by following raw material by weight:
Tea polysaccharide 55 cherry powder 10 Radix Gentianae Macrophyllae powder 6
Semen Camelliae extract 4 Radix Angelicae Dahuricae powder 4 powder of Radix Puerariae 15
Radix Cyathulae powder 6;
Semen Camelliae extract used is by mixing by following material by weight:
Unsaturated fatty acid 63 Squalene 35 tea polyphenols 2;
Radix Gentianae Macrophyllae powder used is to be mixed by following material by weight:
Gentianol 40 Radix Gentianae Macrophyllae erythricine 55 Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 5.
Described tea polysaccharide is to extract in Folium Camelliae sinensis or Semen Camelliae (comprising Camellia oil or the Flos Camelliae Japonicae dregs of rice processed by Camellia) or other plant or animal, and the postfermented tea polysaccharide especially extracting with Hunan postfermented tea that is produced from Anhua County is for well.
The Chinese medicine composition for the treatment of goat of the present invention, can be made into the preparations such as tablet, pill, powder, syrup, capsule, drop pill, granule.
The traditional Chinese medical science thinks, gout is due to the damp and hot heresy that is affected by the cold, and causes QI-blood circulation not smooth, obstruction of meridians and collaterals; Or phlegm-turbidity and blood stasis blood, hinder in channel tunnel, go deep into joint muscle arteries and veins and form.Control suitable dispelling cold by warming the meridian, eliminating dampness and dredging channels, heat clearing away dredging collateral, dissipating phlegm and removing blood stasis, all methods of warming and recuperating the spleen and kidney.
The Chinese medicine composition for the treatment of goat of the present invention, adopts tea polysaccharide, cherry powder, Radix Gentianae Macrophyllae powder, Semen Camelliae extract (comprising unsaturated fatty acid, Squalene and tea polyphenols), Radix Angelicae Dahuricae powder, powder of Radix Puerariae and Radix Cyathulae powder as raw material.Tea polysaccharide (Tea Polysaccharide) is a kind of similar ganoderan and ginseng polysaccharide's macromolecular compound (molecular weight: 40,000-100,000); comprise glucose, arabinose, ribose, galactose etc.; there is the effects such as blood sugar lowering, blood fat reducing, anticoagulant, preventing thrombosis shape; can improve QI-blood circulation; prevent phlegm-turbidity and blood stasis blood, and all have positive effect at aspects such as protection blood phase and enhancing human body non-specific immunities.Fructus Pruni pseudocerasi (Prunus pseudocerasus Lindl.) heat warm in nature, has the merit of invigorating the spleen and replenishing QI concurrently, can expelling wind and removing dampness, can reduce the risk of gout outbreak.Radix Gentianae Macrophyllae (Gentiana macrophylla) energy wind-damp dispelling, clearing away damp-heat, stopping numbness pain, cure mainly the diseases such as rheumatalgia, hectic fever hectic fever due to YIN-deficiency.The Radix Angelicae Dahuricae [Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f. or Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana(Boiss.) Shan et Yuan] there is the effects such as the cold expelling of inducing sweat, wind-expelling pain-stopping, dampness leukorrhagia stopping, detumescence and apocenosis.Radix Puerariae (Pueraria lobata) sweet in the mouth cool in nature is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension, neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as have loose bowels.Radix Cyathulae (Radix cyathulae) energy eliminating blood stasis and inducing menstruation, easing joint movement.(chemical name is 2 to Squalene in its Semen Camelliae extract, 6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa carbon, six alkene) there is the different physiological roles such as interior superoxide dismutase (SOD) activity of the body of raising, enhancing human body immunity ability, defying age, resisting fatigue, contribute to treat the diseases such as rheumatoid arthritis; Tea polyphenols (Tea Polyphenols) can be removed harmful free radical strongly, and blocking-up lipid peroxidation process, improves the activity of human body endoenzyme, thereby plays the effect of mutation; Unsaturated fatty acid have keep the relative mobility of cell membrane, to guarantee the normal physiological function of cell, make cholesterol esterification, reduce Blood Cholesterol and triglyceride, reduce blood viscosity, improve the effects such as blood microcirculation.Therefore, the Chinese medicine composition for the treatment of goat of the present invention, has the effects such as heat clearing away dredging collateral, reducing swelling and alleviating pain, expelling wind and removing dampness, clearing away damp-heat, stopping numbness pain, eliminating blood stasis and inducing menstruation, easing joint movement, enhancing human body immunity ability, therefore can treat multiple gout.
The Chinese medicine composition for the treatment of goat of the present invention, selects the patient of the different state of an illness, case history, age, sex, from being in hospital and internal clinic is selected goat case 50 examples, carries out clinical experiment.
One, diagnostic criteria
(i), Western medicine diagnose standard: the standard of formulating for 1997 with reference to American Rheumatism Association:
1. acute arthritis is shown effect more than 1 time and was reached a climax in 24 hours; 2. acute inflammation is confined to indivedual joints; 3. whole joint is kermesinus; 4. the 1st metatarsophalangeal joints swells and ache; 5. one-sided sole of the foot joint acute inflammation; 6. the tophus that has suspicious confirmation; 7. hyperuricemia; 8. asymmetry arthroncus; 9. outbreak can stop voluntarily.
At least possess wherein 4, and get rid of secondary gout, can be diagnosed as constitutional acute gout.
(ii), tcm diagnosis standard: tcm diagnosis is arthromyodynia, dialectical genus damp-heat arthralgia resistance card, disease sees redness and swelling of joints burning pain, limitation of activity, it is hot, thirsty to occur together, hyperhidrosis, dim complexion (take sallow as many), yellow urine, yellow fur, slippery and rapid pulse etc.
Two, physical data
Meet diagnosis and the observation case of inclusive criteria totally 50 examples, male 32 examples wherein, female's 18 examples, 32～45 years old age, average 36 years old; The course of disease 2～5 years, average out to 3 years.
Three, exclusion standard
1. age <18 year or >65 year, trimester of pregnancy or women breast-feeding their children, allergic constitution and those who are allergic to this drug; 2. merge the serious primary disease such as cerebrovascular, cardiovascular, liver, kidney and hemopoietic system, psychotic; 3. lopsided, stiff, the disability person of arthritis severe in late period; 4. do not meet inclusive criteria, not medication in accordance with regulations, or data is not congruent to affect the treatment or safety judgement person.
Four, Therapeutic Method
[weight share is by 55 parts of tea polysaccharide for the Chinese medicine composition for the treatment of goat of the present invention for oral administration, 10 parts of cherry powder, 6 parts, Radix Gentianae Macrophyllae powder, 4 parts of Semen Camelliae extracts (wherein, in unsaturated fatty acid, the percentage by weight of each composition is: oleic acid 60, linoleic acid 20, linolenic acid 20), 4 parts, Radix Angelicae Dahuricae powder, 15 parts of powder of Radix Puerariae, 6 parts, Radix Cyathulae powder mixes, Semen Camelliae extract used is by 63 parts of unsaturated fatty acids by weight, 35 parts of Squalenes, 2 parts of tea polyphenols mix, Radix Gentianae Macrophyllae powder used is by 40 parts of gentianols by weight, 55 parts of Radix Gentianae Macrophyllae erythricines, 5 parts, Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol mixes], 10 grams/day, divide and take for three times, during patient treatment, withdraw the medicine of other treatment gout, forbid high purine diet, maror and drinks etc.Treat observe the curative effect after 2 weeks.
Five, efficacy assessment standard
With reference to < < new Chinese medicine guideline of clinical investigations > > Ministry of Health of the People's Republic of China. new Chinese medicine guideline of clinical investigations, the 2nd volume (S). Beijing: Ministry of Health of the People's Republic of China prints, 1995. ］ curative effect determinate standard in, symptom disappears completely, joint function recovery is normal, and main physico-chemical examination index is normally clinical cure; Cardinal symptom disappears, and function of joint is recovered substantially, and main physico-chemical examination index normal is effective; Cardinal symptom disappears substantially, and main function of joint and main physical and chemical index make moderate progress as effectively; With before treatment, compare each side and be all not improved as invalid.
Six, therapeutic effect
According to statistics, this group case has been treated all kinds of goat patient 50 examples altogether, wherein: cure 36 examples, effective 4 examples, effective 2 examples, invalid 8 examples, total effective rate 84.0%.
By above-mentioned statistical data, shown that the Chinese medicine composition for the treatment of goat of the present invention has good curative effect to gout.
The specific embodiment
Below in conjunction with embodiment, the present invention is described further.Explanation is below the mode exemplifying, but protection scope of the present invention is not limited to this.
Embodiment mono-:
The Chinese medicine composition of the treatment goat of the present embodiment is to be mixed by following raw material by weight:
Tea polysaccharide 55 cherry powder 10 Radix Gentianae Macrophyllae powder 6
Semen Camelliae extract 4 Radix Angelicae Dahuricae powder 4 powder of Radix Puerariae 15
Radix Cyathulae powder 6;
Its preparation method is: above-mentioned raw materials is dropped in trough type mixing machine, add to account for this example of raw material gross weight 3-8%(and adopt 5% simultaneously) food-grade adhesive, limit edged stirs; Then add pure edible ethanol, according on a small quantity, repeatedly adding, agglomerating to holding; Then, the granulator that is 10-20 order (this example adopts 15 orders) by its via hole diameter is granulated, and proceeds in baking oven and adopt 5h 40-60 ℃ of (this example adopts 50 ℃) this example of constant pressure and dry 4-7h(after granulation); Then, the capsule filling machine fill through 20000/h is become to capsule, obtain the Chinese medicine composition finished product for the treatment of goat of the present invention, its weight of every is 0.45g.
This example tea polysaccharide used is the postfermented tea polysaccharide being extracted by Hunan postfermented tea that produce Anhua County.
This example Semen Camelliae extract used is to be mixed by following material by weight:
Unsaturated fatty acid 63 is Squalene 35 tea polyphenols 2 not;
(specific to this example: unsaturated fatty acid 0.63 * 4=2.52 part, Squalene 0.35 * 4=1.4 part, tea polyphenols 0.02 * 4=0.08 part; In unsaturated fatty acid, the percentage by weight of each composition is:
Oleic acid 60 linoleic acid 20 linolenic acid 20)
This example Radix Gentianae Macrophyllae powder used is to be mixed by following material by weight:
Gentianol 40 Radix Gentianae Macrophyllae erythricine 55 Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 5;
(specific to this example: gentianol 0.40 * 6=2.4 part, Radix Gentianae Macrophyllae erythricine 0.55 * 6=3.3 part, Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 0.05 * 6=0.3 part)
This example cherry powder used is to be prepared from by following method:
A, enucleation: get fresh cherry, remove Semen Persicae, obtain Fructus Pruni pseudocerasi sarcocarp;
B, making beating: Fructus Pruni pseudocerasi sarcocarp is dropped in beater together with accounting for the clear water of Fructus Pruni pseudocerasi sarcocarp weight 40%, break into 60 object Fructus Pruni pseudocerasi juices;
C, alcohol soak: in Fructus Pruni pseudocerasi juice, add edible ethanol, limit edged stirs, and after being 70%, in temperature, are to soak 40min at 60 ℃ to the volumetric concentration of ethanol, cross 80 mesh sieves, respectively soak with ethanol liquid and Fructus Pruni pseudocerasi sarcocarp slag;
D, water extraction: the boiling water to adding 3 times of weight in Fructus Pruni pseudocerasi sarcocarp slag, stir evenly, standingly under normal pressure to water temperature, be down to 40 ℃, cross 120 mesh sieves, obtain Sucus pruni pseudocerasi extract;
E, Sucus pruni pseudocerasi extract concentrate: by Sucus pruni pseudocerasi extract, in vacuum, be that 0.7MPa, temperature are that in being concentrated into every 100ml liquid at 70 ℃, solid content is 6g, obtain Fructus Pruni pseudocerasi water extracting liquid;
F, soak with ethanol liquid concentrate: by soak with ethanol liquid, in vacuum, be that 0.5MPa, temperature are that in being concentrated into every 100ml concentrated solution at 60 ℃, solid content is 12g, obtain soak with ethanol concentrated solution;
G, powder process: by Fructus Pruni pseudocerasi water extracting liquid: the part by weight of soak with ethanol concentrated solution=2:1 mixes, then spraying is dry, obtains cherry powder.
This example Radix Angelicae Dahuricae powder used is to be prepared from by following method:
A, extraction: to adding 3 times of weight in the Radix Angelicae Dahuricae, by ethyl acetate: the solvent that 5% aqueous citric acid solution mixes by the part by weight of 3:1, at 60 ℃, extract 1.5h, cross 80 mesh sieves, respectively Radix Angelicae Dahuricae extracting solution and Radix Angelicae Dahuricae slag;
B, separation: extraction Radix Angelicae Dahuricae extracting solution is put into tank, after it is cooled to room temperature and stratification, collect ethyl acetate layer liquid;
C, the contracting of ethyl acetate layer dope: by ethyl acetate layer liquid, in vacuum, be that 0.4MPa, temperature are that in being concentrated into every 100ml liquid at 40 ℃, solid content is 8g, obtain ethyl acetate layer concentrated solution;
D, water extraction: to the clear water that adds 2 times of weight in Radix Angelicae Dahuricae slag, boil and extract 1h, cross 120 mesh sieves, obtain Radix Angelicae Dahuricae pulp water extract;
E, Radix Angelicae Dahuricae pulp water extract concentrate: by Radix Angelicae Dahuricae pulp water extract, in vacuum, be that 0.7MPa, temperature are at 70 ℃, to be concentrated into 1/3 of original volume, obtain Radix Angelicae Dahuricae slag water extracting liquid;
F, powder process: by ethyl acetate layer concentrated solution: the part by weight of Radix Angelicae Dahuricae slag water extracting liquid=2.5:1 mixes, then spraying is dry, obtains Radix Angelicae Dahuricae powder.
This example Radix Cyathulae powder used is to be prepared from by following method:
A, pulverizing: Radix Cyathulae is processed into 35 object Radix Cyathulae powder;
B, alcohol extraction: in Radix Cyathulae powder, add the edible ethanol that 1.5 times of weight, volumetric concentration are 80%, stir evenly, being dipped at normal temperatures and pressures solid content in every 100ml solution is 3g, cross 120 mesh sieves, obtains Radix Cyathulae soak with ethanol liquid;
C, powder process: by Radix Cyathulae soak with ethanol liquid, at 50 ℃, vacuum, be under 0.55MPa, to be concentrated into 1/4 of original volume, then spraying is dry, obtains Radix Cyathulae powder.
This example powder of Radix Puerariae used is to be prepared from by following method:
A, washing: Radix Puerariae is dropped in the water of 2.5 times of weight, boil and extract 30min, cross 80 mesh sieves, obtain respectively Radix Puerariae water extraction liquid and Radix Puerariae slag;
B, alcohol extraction: to dropping into the edible ethanol that 2.5 times of weight, volumetric concentration are 80% in Radix Puerariae slag, reflux, extract, 40min, filters, and obtains Radix Puerariae slag ethanol extract;
C, Radix Puerariae water extraction liquid concentrate: by Radix Puerariae water extraction liquid, in vacuum, be that 0.4MPa, temperature are that in being concentrated into every 100ml solution at 70 ℃, solid content is 6g, obtain Radix Puerariae water extracting liquid;
D, Radix Puerariae water extraction cream powdering: Radix Puerariae water extracting liquid is spray-dried, obtain water extraction powder of Radix Puerariae;
E, Radix Puerariae slag ethanol extract are concentrated: by Radix Puerariae slag ethanol extract, in vacuum, be that 0.5MPa, temperature are that at 45 ℃, to be concentrated into ethanol volumetric concentration be 45%, obtain Radix Puerariae slag ethanol extraction concentrated solution, add again the acidic alumina that accounts for Radix Puerariae slag ethanol extraction concentrated solution weight 12%, stir 18min, filter, obtain Radix Puerariae slag ethanol extraction concentrated solution;
F, Radix Puerariae slag ethanol extraction cream powdering: Radix Puerariae slag ethanol extraction concentrated solution is spray-dried, obtain alcohol extraction Radix Puerariae ground-slag;
G, mixing: by water extraction powder of Radix Puerariae: alcohol extraction Radix Puerariae ground-slag mixes according to the part by weight of 1:6, cross 100 mesh sieves, obtains powder of Radix Puerariae.
Embodiment bis-:
The Chinese medicine composition of the treatment goat of the present embodiment is to be mixed by following raw material by weight:
Tea polysaccharide 50 cherry powder 15 Radix Gentianae Macrophyllae powder 7
Semen Camelliae extract 3 Radix Angelicae Dahuricae powder 5 powder of Radix Puerariae 15
Radix Cyathulae powder 5;
(specific to this example: unsaturated fatty acid 0.65 * 3=1.95 part, Squalene 0.32 * 3=0.96 part, tea polyphenols 0.03 * 3=0.09 part; In unsaturated fatty acid, the percentage by weight of each composition is:
Oleic acid 70 linoleic acid 15 linolenic acid 15)
This example Radix Gentianae Macrophyllae powder used is to be mixed by following material by weight:
Gentianol 40 Radix Gentianae Macrophyllae erythricine 55 Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 5;
(specific to this example: gentianol 0.45 * 7=3.15 part, Radix Gentianae Macrophyllae erythricine 0.50 * 7=3.5 part, Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 0.05 * 7=0.35 part)
Its preparation method is: above-mentioned raw materials is dropped in trough type mixing machine, add to account for this example of raw material gross weight 10-16%(and adopt 12% simultaneously) food-grade adhesive, limit edged stirs; Then add pure edible ethanol, according on a small quantity, repeatedly adding, agglomerating to holding; Then, the granulator that is 10-20 order (this example adopts 15 orders) by its via hole diameter is granulated, and proceeds in baking oven and adopt 5h 40-60 ℃ of (this example adopts 50 ℃) this example of constant pressure and dry 4-7h(after granulation); Then, will process through the tablet tablet machine of 40000/h, and obtain the Chinese medicine composition finished product for the treatment of goat of the present invention, its weight of every is 0.65g.
Other is identical with embodiment mono-.
The Chinese medicine composition for the treatment of goat of the present invention, is used for the treatment of goat, and the goat patient who is applicable to all ages and classes and sex takes.
Claims (6)
1. treat a Chinese medicine composition for goat, it is characterized in that being mixed by following raw material by weight:
Tea polysaccharide 40-55 cherry powder 10-15 Radix Gentianae Macrophyllae powder 5-10
Semen Camelliae extract 3-6 Radix Angelicae Dahuricae powder 4-6 powder of Radix Puerariae 10-15
Radix Cyathulae powder 3-8;
Described Semen Camelliae extract is to be mixed by following material by weight:
Unsaturated fatty acid 50-70 Squalene 25-40 tea polyphenols 1.5-3.
2. treat according to claim 1 the Chinese medicine composition of goat, it is characterized in that, described cherry powder is to be prepared from by following method:
A, enucleation: get fresh cherry, remove Semen Persicae, obtain Fructus Pruni pseudocerasi sarcocarp;
B, making beating: Fructus Pruni pseudocerasi sarcocarp is dropped in beater together with accounting for the clear water of Fructus Pruni pseudocerasi sarcocarp weight 30-50%, break into 40-80 object Fructus Pruni pseudocerasi juice;
C, alcohol soak: in Fructus Pruni pseudocerasi juice, add edible ethanol, limit edged stirs, and after being 60-80%, in temperature, are to soak 30-45min at 45-70 ℃ to the volumetric concentration of ethanol, cross 60-100 mesh sieve, respectively soak with ethanol liquid and Fructus Pruni pseudocerasi sarcocarp slag;
D, water extraction: the boiling water to adding 2-3 times of weight in Fructus Pruni pseudocerasi sarcocarp slag, stir evenly, standingly under normal pressure to water temperature, be down to 30-45 ℃, cross 100-140 mesh sieve, obtain Sucus pruni pseudocerasi extract;
E, Sucus pruni pseudocerasi extract concentrate: by Sucus pruni pseudocerasi extract, in vacuum, be that 0.6-0.8MPa, temperature are that in being concentrated into every 100ml liquid at 60-80 ℃, solid content is 5-8g, obtain Fructus Pruni pseudocerasi water extracting liquid;
F, soak with ethanol liquid concentrate: by soak with ethanol liquid, in vacuum, be that 0.35-0.65MPa, temperature are that in being concentrated into every 100ml concentrated solution at 50-70 ℃, solid content is 10-15g, obtain soak with ethanol concentrated solution;
G, powder process: by Fructus Pruni pseudocerasi water extracting liquid: the part by weight of soak with ethanol concentrated solution=1.5-2.5:1 mixes, then spraying is dry, obtains cherry powder.
3. treat according to claim 1 the Chinese medicine composition of goat, it is characterized in that, described Radix Angelicae Dahuricae powder is to be prepared from by following method:
A, extraction: to adding 2-4 times of weight in the Radix Angelicae Dahuricae, by ethyl acetate: the solvent that 5% aqueous citric acid solution mixes by the part by weight of 3-4:1, at 50-75 ℃, extract 1-2h, cross 60-100 mesh sieve, respectively Radix Angelicae Dahuricae extracting solution and Radix Angelicae Dahuricae slag;
B, separation: extraction Radix Angelicae Dahuricae extracting solution is put into tank, after it is cooled to room temperature and stratification, collect ethyl acetate layer liquid;
C, the contracting of ethyl acetate layer dope: by ethyl acetate layer liquid, in vacuum, be that 0.3-0.45MPa, temperature are that in being concentrated into every 100ml liquid at 35-50 ℃, solid content is 6-10g, obtain ethyl acetate layer concentrated solution;
D, water extraction: to the clear water that adds 1.5-3 times of weight in Radix Angelicae Dahuricae slag, boil and extract 0.5-1.5h, cross 100-140 mesh sieve, obtain Radix Angelicae Dahuricae pulp water extract;
E, Radix Angelicae Dahuricae pulp water extract concentrate: by Radix Angelicae Dahuricae pulp water extract, in vacuum, be that 0.6-0.8MPa, temperature are at 60-80 ℃, to be concentrated into the 1/4-1/2 of original volume, obtain Radix Angelicae Dahuricae slag water extracting liquid;
F, powder process: by ethyl acetate layer concentrated solution: the part by weight of Radix Angelicae Dahuricae slag water extracting liquid=2-3:1 mixes, then spraying is dry, obtains Radix Angelicae Dahuricae powder.
4. treat according to claim 1 the Chinese medicine composition of goat, it is characterized in that, described Radix Cyathulae powder is to be prepared from by following method:
A, pulverizing: Radix Cyathulae is processed into 30-40 object Radix Cyathulae powder;
B, alcohol extraction: in Radix Cyathulae powder, add the edible ethanol that 1-2 times of weight, volumetric concentration are 70-90%, stir evenly, being dipped at normal temperatures and pressures solid content in every 100ml solution is 2.5-4.5g, cross 100-140 mesh sieve, obtains Radix Cyathulae soak with ethanol liquid;
C, powder process: by Radix Cyathulae soak with ethanol liquid, at 40-55 ℃, vacuum, be under 0.45-0.6MPa, to be concentrated into the 1/5-1/3 of original volume, then spraying is dry, obtains Radix Cyathulae powder.
5. treat according to claim 1 the Chinese medicine composition of goat, it is characterized in that, described powder of Radix Puerariae is to be prepared from by following method:
A, washing: Radix Puerariae is dropped in the water of 2-3 times of weight, boil and extract 25-40min, cross 60-100 mesh sieve, obtain respectively Radix Puerariae water extraction liquid and Radix Puerariae slag;
B, alcohol extraction: to dropping into the edible ethanol that 2-3 times of weight, volumetric concentration are 75-85% in Radix Puerariae slag, reflux, extract, 30-45min, filters, and obtains Radix Puerariae slag ethanol extract;
C, Radix Puerariae water extraction liquid concentrate: by Radix Puerariae water extraction liquid, in vacuum, be that 0.3-0.45MPa, temperature are that in being concentrated into every 100ml solution at 60-75 ℃, solid content is 4-8g, obtain Radix Puerariae water extracting liquid;
D, Radix Puerariae water extraction cream powdering: Radix Puerariae water extracting liquid is spray-dried, obtain water extraction powder of Radix Puerariae;
E, Radix Puerariae slag ethanol extract are concentrated: by Radix Puerariae slag ethanol extract, in vacuum, be that 0.4-0.6MPa, temperature are that at 40-50 ℃, to be concentrated into ethanol volumetric concentration be 40-50%, obtain Radix Puerariae slag ethanol extraction concentrated solution, add again the acidic alumina that accounts for Radix Puerariae slag ethanol extraction concentrated solution weight 10-15%, stir 15-20min, filter, obtain Radix Puerariae slag ethanol extraction concentrated solution;
F, Radix Puerariae slag ethanol extraction cream powdering: Radix Puerariae slag ethanol extraction concentrated solution is spray-dried, obtain alcohol extraction Radix Puerariae ground-slag;
G, mixing: by water extraction powder of Radix Puerariae: alcohol extraction Radix Puerariae ground-slag mixes according to the part by weight of 1:5-7, cross 80-120 mesh sieve, obtains powder of Radix Puerariae.
6. treat according to claim 1 the Chinese medicine composition of goat, it is characterized in that, described Radix Gentianae Macrophyllae powder is to be mixed by following material by weight:
Gentianol 24-40 Radix Gentianae Macrophyllae erythricine 50-65 Radix Gentianae Macrophyllae Radix Sophorae Flavescentis phenol 2-5.
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| CN105126067A (en) * | 2015-09-30 | 2015-12-09 | 北京知蜂堂蜂产品有限公司 | Composition for reducing uric acid and application thereof |
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
| CN102670879A (en) * | 2012-06-01 | 2012-09-19 | 湖南省回春堂药业有限公司 | Prescriptions for preventing and treating gout and manufacturing method thereof |
| CN103053715A (en) * | 2011-10-22 | 2013-04-24 | 杨煜炜 | Acid tea and preparation method thereof |
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
| CN103053715A (en) * | 2011-10-22 | 2013-04-24 | 杨煜炜 | Acid tea and preparation method thereof |
| CN102670879A (en) * | 2012-06-01 | 2012-09-19 | 湖南省回春堂药业有限公司 | Prescriptions for preventing and treating gout and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105126067A (en) * | 2015-09-30 | 2015-12-09 | 北京知蜂堂蜂产品有限公司 | Composition for reducing uric acid and application thereof |
| CN105126067B (en) * | 2015-09-30 | 2018-05-22 | 北京知蜂堂健康科技股份有限公司 | A kind of composition of anti-trioxypurine and application thereof |
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