Summary of the invention
Technical problem to be solved by this invention provide a kind ofly have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid quench one's thirst, invigorating QI to consolidate the body surface resistance, diuresis poison holding, enrich blood invigorate blood circulation, the kidney warming mends effects such as essence, benefiting QI and nourishing blood, invigorating the lung and the kidney, dissipating phlegm and removing blood stasis, expelling wind and removing dampness, numbness relieving and pain relieving, liver heat removing function of gallbladder promoting, dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence, is used to Chinese medicine of treating gout and preparation method thereof.
The technical scheme that the present invention taked is a kind of Chinese medicine of treating gout of invention, processes its raw materials of effective components composition percentage by weight to be:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 25-35
(molecular formula is C to xylitol
5H
12O
5) 20-30
Implant 40-50.
The technical scheme of optimizing one: processing its raw materials of effective components composition percentage by weight is:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 25
Xylitol 30 implants 45.
The technical scheme of optimizing two: processing its raw materials of effective components composition percentage by weight is:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 35
Xylitol 20 implants 45.
The technical scheme of optimizing three: processing its raw materials of effective components composition percentage by weight is:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 30
Xylitol 25 implants 45.
The technical scheme of optimizing four: processing its raw materials of effective components composition percentage by weight is:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 30
Xylitol 30 implants 40.
The technical scheme of optimizing five: processing its raw materials of effective components composition percentage by weight is:
The Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 25
Xylitol 25 implants 50.
Simultaneously, a kind of method that is used to prepare the Chinese medicine of above-mentioned treatment gout is provided also, its technical process is following:
A, respectively get the equivalent weight share the Radix Astragali [Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao],
Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels),
Stigma Maydis (Zea mays L.),
Caulis Trachelospermi (Trachelospermum jasminoides (Lindl.) Lem.),
Cordyceps (Cordyceps sinensis (BerK.) Sacc.),
Fructus Pruni pseudocerasi (Prunus pseudocerasus Lindl.),
Radix Puerariae [Pueraria lobata (Willd.) Ohwi Pueraria thomsonii Benth.],
Radix Angelicae Pubescentis (Angelica pubescens Maxim.f.biserrata Shan et Yuan),
(human placenta) is subsequent use for Placenta Hominis;
B, the Radix Astragali with subsequent use, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi place extraction pot, add jar clear water that Chinese medicine gross weight 5-8 doubly measures, and heated and boiled 1.5-2 hour, leach lixiviating solution; Again the jar Chinese medicine slag is added the clear water of the former water yield, heated and boiled 1.5-2 hour, leach lixiviating solution; Merge above-mentioned twice lixiviating solution subsequent use;
C, lixiviating solution heating subsequent use in the B step is concentrated, it is subsequent use to get water extracting liquid;
D, the Radix Puerariae with subsequent use, Radix Angelicae Pubescentis, Placenta Hominis place extraction pot, add jar ethanol that Chinese medicine gross weight 4-8 doubly measures, and extract 1.5-2 hour, leach lixiviating solution; The ethanol that again the jar Chinese medicine slag is added former amount of alcohol extracted 1.5-2 hour, leached lixiviating solution; Merge above-mentioned twice lixiviating solution subsequent use;
E, lixiviating solution heating subsequent use in the D step is concentrated, it is subsequent use to get the alcohol extraction concentrated solution;
F, merge subsequent use alcohol extraction concentrated solution in water extracting liquid subsequent use in the C step and the E step, spray drying makes the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder, and is subsequent use;
G, weight share are got the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder 25-35 part, xylitol 20-30 part, implant 40-50 part, and total amount is 100 parts, mix homogeneously.
The Chinese medicine of treatment gout of the present invention can be processed graininess or tablet shape or capsule shape finished product.
In the prescription of the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, seven kinds of extract drugs extract powders of Placenta Hominis, each medicine can adopt the equivalent weight proportioning, also can adopt non-equivalent weight proportioning; When adopting non-equivalent weight proportioning, its percentage by weight separately is:
Radix Astragali 10-15 Radix Angelicae Sinensis 10-15 Stigma Maydis 10-20
Caulis Trachelospermi 10-20 Cordyceps 5-10 Fructus Pruni pseudocerasi 5-15
Radix Puerariae 10-20 Radix Angelicae Pubescentis 10-20 Placenta Hominis 5-15.
Used implant adopts Sugarless type implant (can adopt the water solublity dextrin, perhaps other implant); Also can contain the ethyl cellulose that gathers that accounts for gross weight 0.2%-0.5% in the implant.
The traditional Chinese medical science thinks, gout is because the damp and hot heresy that is affected by the cold, and it is not smooth to cause QI-blood circulation, the resistance of meridians numbness; Or phlegm-turbidity and blood stasis blood, hinder in channel tunnel, go deep into joint muscle arteries and veins and form.Control suitable dispelling cold by warming the meridian, eliminating dampness and dredging channels, heat clearing away collateral dredging, dissipating phlegm and removing blood stasis, all methods of warming and recuperating the spleen and kidney.
The present invention adopt have the Radix Astragali of invigorating QI to consolidate the body surface resistance, yang invigorating, diuresis poison holding effect and the effect of invigorating blood circulation of enriching blood is arranged, the Radix Angelicae Sinensis that can dispel rheumatic arthralgia is as monarch drug; Being aided with can invigorating the lung and the kidney, the Cordyceps of hemostasis and phlegm and have the Radix Angelicae Pubescentis of expelling wind and removing dampness, numbness relieving and pain relieving effect and have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal Radix Puerariae and can mend Placenta Hominis smart, benefiting QI and nourishing blood by the kidney warming; Help again with the Stigma Maydis of liver heat removing function of gallbladder promoting and dispelling wind and removing obstruction in the collateral, removing heat from blood repercussive Caulis Trachelospermi and can QI invigorating, the Fructus Pruni pseudocerasi of wind-damp dispelling; Nine medicines share; Have expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid quench one's thirst, invigorating QI to consolidate the body surface resistance, diuresis poison holding, enrich blood invigorate blood circulation, effects such as the kidney warming is mended essence, benefiting QI and nourishing blood, invigorating the lung and the kidney, dissipating phlegm and removing blood stasis, expelling wind and removing dampness, numbness relieving and pain relieving, liver heat removing function of gallbladder promoting, dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence, so can treat multiple gout.Xylitol in the medicine is a kind of functional sweetener, can participate in body metabolism, behind the entering blood, do not need insulin just can penetrate cell, and accretion rate is fast, can not cause blood sugar increasing, therefore, as adjuvant, can regulate mouthfeel.
The Chinese medicine of treatment gout of the present invention is selected the patient of the different state of an illness, case history, age, sex, from being in hospital and goat case 30 examples are selected in the internal medicine outpatient service, carries out clinical experiment.
One, diagnostic criteria
(1), Western medicine diagnose standard: the standard of formulating with reference to American Rheumatism Association 1997:
1. the acute arthritis outbreak reaches a climax more than 1 time and in 24 hours; 2. acute inflammation is confined to indivedual joints; 3. whole joint is kermesinus; 4. the 1st metatarsophalangeal joints swells and ache; 5. one-sided sole of the foot joint acute inflammation; The tophus that 6. suspicious confirmation is arranged; 7. hyperuricemia; 8. asymmetry arthroncus; 9. outbreak can stop voluntarily.
At least possess wherein 4, and get rid of secondary gout, can be diagnosed as the constitutional acute gout.
(2), the tcm diagnosis standard: tcm diagnosis is an arthromyodynia, the damp and hot numbness of dialectical genus resistance card, disease sees redness and swelling of joints burning pain, limitation of activity, it is hot, thirsty to occur together, hyperhidrosis, dim complexion (is many with the sallow), yellow urine, yellow fur, slippery and rapid pulse etc.
Two, physical data
The observation case that meets diagnosis and include standard in is totally 30 examples, wherein male 20 examples, women 10 examples, 50~40 years old age, average 36 years old; The course of disease 1~6 year, average out to 4 years.
Three, exclusion standard
1. age<18 year old or>65 years old, trimester of pregnancy or women breast-feeding their children, allergic constitution and to this medicine allergy sufferers; 2. merge serious primary disease such as cerebrovascular, cardiovascular, liver, kidney and hemopoietic system, the psychotic; 3. lopsided, stiff, the disability person of arthritis severe in late period; 4. do not meet the standard of including in, by the regulation medication, or data is not congruent affects the treatment or safety judgement person.
Four, Therapeutic Method
The Chinese medicine of treatment gout of the present invention for oral administration (weight share is formulated by the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Radix Puerariae, Radix Angelicae Pubescentis, 30 parts of Placenta Hominis extract powders, 25 parts of xylitol, 45 parts of implants], 25 gram/skies divide and take for three times; Withdraw the medicine of other treatment gout during the patient treatment, forbid high purine diet, maror and drinks etc.Observe the curative effect after 3 weeks of treatment.
Five, efficacy assessment standard
Reference " new Chinese medicine clinical research guideline " [Ministry of Health of the People's Republic of China. new Chinese medicine clinical research guideline; The 2nd volume (S). Beijing: Ministry of Health of the People's Republic of China prints; 1995.] middle curative effect determinate standard; The symptom complete obiteration, joint function recovery is normal, and main physico-chemical examination index normally is a clinical cure; Cardinal symptom disappears, and function of joint is recovered basically, and main physico-chemical examination index is basic to be produce effects normally; Cardinal symptom disappears basically, and main function of joint and main physical and chemical index make moderate progress to effectively; With the treatment before compare each side all do not have obviously be improved as invalid.
Six, therapeutic effect
According to statistics, this group case has been treated all kinds of goat patient 30 examples altogether, wherein: cure 22 examples, produce effects 4 examples, effective 2 examples, invalid 2 examples, total effective rate 93.3%.
Show that by above-mentioned statistical data the Chinese medicine of treatment gout of the present invention has curative effect preferably to gout, total effective rate reaches 93.3%.
The specific embodiment
Embodiment one:
A, get each 50 kilograms of the Radixs Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis respectively, subsequent use;
B, get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi and clean, dry, put into extraction pot after the chopping with clear water; In jar, add the clear water of 1.8-2.4 ton, be heated to boiling, in 95-105 ℃ water lixiviate 1.5-2 hour, leach lixiviating solution; Other adds 1.8-2.4 ton clear water, boils again, extracts 2 hours, leaches waste after the lixiviating solution; Merge above-mentioned twice lixiviating solution subsequent use;
C, lixiviating solution heating subsequent use in the b step is concentrated, it is subsequent use to get water extracting liquid;
D, get subsequent use Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis, put into extraction pot after cleaning, dry, shred with clear water; In jar, add 70% ethanol (weight content, down together) of 1.2-1.5 ton, be heated to boiling, lixiviate 1.5-2 hour, leach lixiviating solution; Other adds 1.2-1.5 ton 70% ethanol, boils again, and lixiviate 2 hours leaches waste after the lixiviating solution; Merge above-mentioned twice lixiviating solution subsequent use;
E, lixiviating solution heating subsequent use in the d step is concentrated, it is subsequent use to get the alcohol extraction concentrated solution;
F, merge subsequent use alcohol extraction concentrated solution in water extracting liquid subsequent use in the c step and the e step, spray drying makes the Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, Placenta Hominis extract powder, and is subsequent use;
G, get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, 25 kilograms of Placenta Hominis extract powders, 30 kilograms of xylitol, 45 kilograms in water solublity dextrin (include 0.3 kilogram and gather ethyl cellulose); Total amount is 100 kilograms; Mix, through boiling granulating, after the drying; Granulate, sieve, sterilize, check, packing gets finished product.
Embodiment two:
The a-f step of present embodiment is identical with embodiment one; The g step is: get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, 35 kilograms of Placenta Hominis extract powders, 20 kilograms of xylitol, 45 kilograms in water solublity dextrin (include 0.2 kilogram and gather ethyl cellulose), total amount is 100 kilograms, mixes; Pass through boiling granulating; After the drying, granulate, sieve, sterilize, check, packing gets finished product.
Embodiment three:
The a-f step of present embodiment is identical with embodiment one; The g step is: get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, 30 kilograms of Placenta Hominis extract powders, 25 kilograms of xylitol, 45 kilograms in water solublity dextrin (include 0.4 kilogram and gather ethyl cellulose), total amount is 100 kilograms, mixes; Pass through boiling granulating; After the drying, granulate, sieve, sterilize, check, packing gets finished product.
Embodiment four:
The a-f step of present embodiment is identical with embodiment one; The g step is: get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, 30 kilograms of Placenta Hominis extract powders, 30 kilograms of xylitol, 40 kilograms in water solublity dextrin (include 0.5 kilogram and gather ethyl cellulose), total amount is 100 kilograms, mixes; Pass through boiling granulating; After the drying, granulate, sieve, sterilize, check, packing gets finished product.
Embodiment five:
The a-f step of present embodiment is identical with embodiment one; The g step is: get the subsequent use Radix Astragali, Radix Angelicae Sinensis, Stigma Maydis, Caulis Trachelospermi, Cordyceps, Fructus Pruni pseudocerasi, Radix Puerariae, Radix Angelicae Pubescentis, 25 kilograms of Placenta Hominis extract powders, 25 kilograms of xylitol, 50 kilograms in water solublity dextrin (include 0.5 kilogram and gather ethyl cellulose), total amount is 100 kilograms, mixes; Pass through boiling granulating; After the drying, granulate, sieve, sterilize, check, packing gets finished product.