CN101579492B

CN101579492B - Medicine for treating high blood pressure and preparation method thereof

Info

Publication number: CN101579492B
Application number: CN200910074019XA
Authority: CN
Inventors: 路正平
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-23
Filing date: 2009-03-23
Publication date: 2011-08-24
Anticipated expiration: 2029-03-23
Also published as: CN101579492A

Abstract

A medicine for treating high blood pressure is prepared by the following steps: processed eucommia bark, earthworm and semen plantaginis are mixed with Hangzhou chrysanthemum, rhizona gastrodiae, nacre, common selfheal fruit-spike, dried immature fruit of citron orange, radix salviae miltiorrhizae, red paeony root, white paeony root, rhizoma ligustici wallichii, dried rhizome of rehmannia, the root bark of the peony tree, alisma orientale, tuckahoe, wheat seed, poria with hostood, uncaria, figwort root and liquorice; water is added for decocting the mixture, the decocted liquid is filtered to form extract; then the extract is dried and pulverized to be medicinal powder; at last, the medicinal powder is put into capsules to obtain the medicine. The invention has the efficacies of conditioning yin and yang, stimulating the menstrual flow, calming the nerves, nourishing yin and kidneys, enriching the blood, tonifying qi, performing spasmolysis, stabilizing voltage, nourishing the blood, and activating the channels and collaterals; in addition, the medicine of the invention can effectively lower blood pressure, can keep blood pressure stable and lasting after lowering blood pressure, and can reduce high blood pressure complications. Through clinical observation, the total effective rate of the medicine is 90.0%.

Description

A kind of hypertensive medicine and preparation method thereof that is used for the treatment of

Technical field

The present invention relates to the hypertensive medicine of a kind of treatment, particularly relating to a kind of is the hypertensive Chinese patent medicine of treatment of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.

Background technology

Hypertension is a kind of serious harm health, influences a kind of disease of quality of life, also is to cause hemiplegia of limb, heart failure, cerebral infarction, cerebral hemorrhage, the major reason of renal failure.

Hypertension is a kind of by polygenic inheritance and environmental factors reciprocal action and what produce is the systemic disease of feature with the arteriotony rising, be that the human nerve activity is obstructed, cause blood vessel kinetic system insufficiency of accommodation under cerebral cortex and the cortex, so that the whole body arteriolospasm, the arteriotony of generation increases.Then cause kidney vasospasm and cause renal ischaemia, cause that a series of body fluid change, and cause endocrine minimizing of whole body or loss, thereby facilitate the arteriolar sclerosis of whole body gradually.These diseased regions send pathologic to cerebral cortex again and impact, and impel the function of cortex disorder, form vicious cycle, finally cause the formation of this chronic disease, and be by light to weight, from critical blood pressure to three phases (heavy type) blood pressure.Clinical manifestation has headache, mostly occurs at back brain, also dizziness can be arranged, feeling of fullness in the head, and cervical region is pulled sense, tinnitus, dim eyesight, forgetful, insomnia, unhappiness, weak, numb limbs and tense tendons, cardiopalmus etc.Hypertension is a disease independently, is again the risk factor that causes taking place apoplexy, coronary heart disease, renal failure and retinopathy.Aspect the treatment of hypertension, the common chemical medicament mainly contains diuretic, beta-blocker, calcium antagonist, α receptor blocking agent, angiotensin-convertion enzyme inhibitor, angiotensin ii receptor antagonist etc.Above conventional antihypertensive drugs has certain therapeutic effect to hypertension acute attack, hypertensive crisis and perioperative hypertension etc., and effect rapidly in the therapeutic process of hypertension.But the fluctuation of blood pressure of these medicines in the blood pressure lowering process is big, side effect is big, and easily bounce-back need be taken medicine throughout one's life, is easy to generate the dependency to medicine.Simultaneously these medicines also obviously influence the metabolism of water, electrolyte, blood fat, blood glucose etc., organs such as the coup injury heart, brain, kidney, and also these medicines are to hyperlipidemia, and high blood is glutinous, sclerosis of blood vessels, no improvement effects such as the damage of target organ.

Summary of the invention

The objective of the invention is to overcome the deficiency of existing Therapeutic Method, provide a kind of orally taken for curing hypertensive Chinese medicine composition,, reach the purpose for the treatment of both the principal and secondary aspects of a disease to improve the therapeutic effect of hypertension.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Flos Chrysanthemi 20～30 RHIZONA GASTRODIAE 10～20

Concha Margaritifera 20～30 Spica Prunellaes 10～15

Cortex Eucommiae (parched) 10～15 Fructus Aurantii Immaturuss 10～15

Radix Salviae Miltiorrhizae 20～30 Radix Paeoniae Rubra 10～15

The Radix Paeoniae Alba 10～20 Rhizoma Chuanxiongs 10～15

The Radix Rehmanniae 20～30 Cortex Moutans 10～15

Rhizoma Alismatis 10～15 Poria 15～20

Semen Plantaginis 20～30 Semen Coicis 15～30

Poria cum Radix Pini's 20～30 Ramulus Uncariae Cum Uncis 10～20

Pheretima 10～15 Radix Scrophulariaes 10～20

Radix Glycyrrhizae 2～5.

Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The concrete preparation method of above-mentioned each component being made medicine of the present invention may further comprise the steps:

The Cortex Eucommiae mixed thoroughly with saline run through, forge and fry to coke black; Pheretima is added yellow wine mix thoroughly and run through, fry to little yellow; Semen Plantaginis forged fry to explosion.

The above-mentioned Chinese medicine that cooks is mixed with Flos Chrysanthemi, RHIZONA GASTRODIAE, Concha Margaritifera, Spica Prunellae, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Rehmanniae, Cortex Moutan, Rhizoma Alismatis, Poria, Semen Coicis, Poria cum Radix Pini, Ramulus Uncariae Cum Uncis, Radix Scrophulariae, Radix Glycyrrhizae, decoct with water 3 times, each 1～2 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.0～1.2 (50 ℃), after 50～60 ℃ of dryings, be ground into 120 purpose medicated powder, sterilization is made capsule in incapsulating.

The traditional Chinese medical science thinks that hypertension is to be worried because of depressed emotion, susceptible to anger to cause depression of liver-QI, fire-transformation impairment of YIN; Or because of intemperance of taking food, hungry full inappropriate, taste are injured, expectorant turbid in due to the reasons such as life, old asthenia, Liver and kidney imbalance of YIN and YANG.Treatment should be based on coordinating YIN and YANG, stimulate the menstrual flow calm the nerves, YIN nourishing is supported kidney, blood yiqi, spasmolytic voltage stabilizing, it is active to nourish blood.In the prescription of the present invention, Flos Chrysanthemi dispelling wind and heat pathogens, suppressing liver-YANG, liver heat removing and eyesight improving; RHIZONA GASTRODIAE, Concha Margaritifera endogenous wind stopping relieving convulsion, suppressing liver-YANG, liver heat removing and eyesight improving, tranquillizing the mind by relieving convulsion; The Spica Prunellae clearing away heat-fire makes eye bright; Cortex Eucommiae (parched) invigorating the liver and kidney, bone and muscle strengthening; Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, relieving restlessness are calmed the nerves, clearing away heat and cooling blood; Rhizoma Chuanxiong nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG; The Radix Rehmanniae, Cortex Moutan clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling; Rhizoma Alismatis, Poria promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming expels the heat-evil; Semen Plantaginis, Semen Coicis, Poria cum Radix Pini's promoting diuresis to eliminate damp pathogen, make eye bright eliminate the phlegm, heat clearing away spleen invigorating, mind tranquilizing and the heart calming; Ramulus Uncariae Cum Uncis, Pheretima heat clearing away suppressing the hyperactive liver, endogenous wind stopping relieving convulsion, clearing heat for calming endogenous wind, collateral dredging diuresis; Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication YIN nourishing; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicine compatibilities, have coordinating YIN and YANG, stimulate the menstrual flow calm the nerves, YIN nourishing is supported kidney, blood yiqi, spasmolytic voltage stabilizing, the active effect that nourishes blood, and can effectively bring high blood pressure down, and stable lasting after the blood pressure lowering, can reduce the generation of hypertension complication.

For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 500 routine hyperpietics that the curative effect of hypertension therapy of the present invention is carried out clinical observation.

500 routine cases are divided into two groups at random, every group 250 example.Male 136 examples in the matched group, women 114 examples; 30～40 years old 26 age example, 41～50 years old 68 example, 51～60 years old 62 example, 60～70 years old 64 example, 30 examples more than 71 years old; The course of disease 3 months～3 years.Male 131 examples in the treatment group, women 119 examples; 30～40 years old 28 age example, 41～50 years old 66 example, 51～60 years old 60 example, 60～70 years old 67 example, 31 examples more than 71 years old; The course of disease 2 months～4 years.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse the difference not statistically significant, have comparability.All cases are all diagnosed with reference to hypertensive diagnostic criteria in " internal medicine ".

Matched group adopts appropriate exercise, rational diet, and oral captopril 25mg, every day 3 times.Treatment is organized oral medicine of the present invention and is treated, and each 2, every day 3 times.

Criterion of therapeutical effect: with reference to the therapeutic goal of the Chinese hypertension prevention and control guide of Chinese hypertension alliance revision in 1999, produce effects: diastolic pressure (DBP) decline＞10mmHg also reaches normal range; Though perhaps do not reduce to normal, descended 20mmHg or more than.Effectively: DBP decline＜10mmHg, but reached normal range; Or decline＞10mmHg, but do not reduce to normal; Or systolic pressure (SBP) decline＞30mmHg.Invalid: as not reach above-mentioned efficiency index person.Curative effect comparative result after two groups of cases are treated sees Table 1.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Get Cortex Eucommiae 150g, add saline and mix thoroughly and run through, forge and fry to coke black, silk is easily broken for degree, cools; Get Pheretima 150g and add yellow wine and mix thoroughly and run through, fry, cool to little yellow; Semen Plantaginis 300g forged fry to explosion.

With above-mentioned Chinese medicine that cooks and 300g Flos Chrysanthemi, 200g RHIZONA GASTRODIAE, 300g Concha Margaritifera, the 150g Spica Prunellae, 150g Fructus Aurantii Immaturus, 300g Radix Salviae Miltiorrhizae, 150g Radix Paeoniae Rubra, the 200g Radix Paeoniae Alba, 150g Rhizoma Chuanxiong, the 300g Radix Rehmanniae, 150g Cortex Moutan, 150g Rhizoma Alismatis, the 200g Poria, 300g Semen Coicis, Poria cum Radix Pini 300g, the 200g Ramulus Uncariae Cum Uncis, the 200g Radix Scrophulariae, the 50g Radix Glycyrrhizae mixes, decoct with water 3 times, each 1 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.2 (50 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Embodiment 2

Get Cortex Eucommiae 130g, add saline and mix thoroughly and run through, forge and fry to coke black, silk is easily broken for degree, cools; Get Pheretima 130g and add yellow wine and mix thoroughly and run through, fry, cool to little yellow; Semen Plantaginis 250g forged fry to explosion.

With above-mentioned Chinese medicine that cooks and 250g Flos Chrysanthemi, 150g RHIZONA GASTRODIAE, 250g Concha Margaritifera, the 130g Spica Prunellae, 130g Fructus Aurantii Immaturus, 250g Radix Salviae Miltiorrhizae, 130g Radix Paeoniae Rubra, the 180g Radix Paeoniae Alba, 130g Rhizoma Chuanxiong, the 250g Radix Rehmanniae, 130g Cortex Moutan, 130g Rhizoma Alismatis, the 180g Poria, 250g Semen Coicis, Poria cum Radix Pini 250g, the 180g Ramulus Uncariae Cum Uncis, the 180g Radix Scrophulariae, the 40g Radix Glycyrrhizae mixes, decoct with water 3 times, each 1.5 hours, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.1 (50 ℃), after 60 ℃ of dryings, be ground into 120 purpose medicated powder, capsule is made in sterilization.

Claims

1. one kind is used for the treatment of hypertensive medicine, is to be crude drug by following parts by weight of traditional Chinese medicines:

Flos Chrysanthemi 20～30 RHIZONA GASTRODIAE 10～20

Concha Margaritifera 20～30 Spica Prunellaes 10～15

Cortex Eucommiae (parched) 10～15 Fructus Aurantii Immaturuss 10～15

Radix Salviae Miltiorrhizae 20～30 Radix Paeoniae Rubra 10～15

The Radix Paeoniae Alba 10～20 Rhizoma Chuanxiongs 10～15

The Radix Rehmanniae 20～30 Cortex Moutans 10～15

Rhizoma Alismatis 10～15 Poria 15～20

Semen Plantaginis 20～30 Semen Coiciss 15～30

Poria cum Radix Pini's 20～30 Ramulus Uncariae Cum Uncis 10～20

Pheretima 10～15 Radix Scrophulariaes 10～20

Radix Glycyrrhizae 2～5

The Cortex Eucommiae mixed thoroughly with saline run through, forge and fry to coke black; Pheretima is added yellow wine mix thoroughly and run through, fry to little yellow; Semen Plantaginis forged fry to explosion;

The above-mentioned Chinese medicine that cooks is mixed with Flos Chrysanthemi, RHIZONA GASTRODIAE, Concha Margaritifera, Spica Prunellae, Fructus Aurantii Immaturus, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Chuanxiong, the Radix Rehmanniae, Cortex Moutan, Rhizoma Alismatis, Poria, Semen Coicis, Poria cum Radix Pini, Ramulus Uncariae Cum Uncis, Radix Scrophulariae, Radix Glycyrrhizae, decoct with water 3 times, each 1～2 hour, merge 3 times decocting liquid, filter, be condensed into 50 ℃ of relative densities and be 1.0～1.2 clear paste, after 50～60 ℃ of dryings, be ground into 120 purpose medicated powder, sterilization is made capsule in incapsulating.