CN103006996B - Medicine for treating accelerated hypertension - Google Patents
Medicine for treating accelerated hypertension Download PDFInfo
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- CN103006996B CN103006996B CN201210584739.2A CN201210584739A CN103006996B CN 103006996 B CN103006996 B CN 103006996B CN 201210584739 A CN201210584739 A CN 201210584739A CN 103006996 B CN103006996 B CN 103006996B
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Abstract
The invention discloses a medicine for treating accelerated hypertension to solve the problem of treatment of accelerated hypertension. The medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of luffa vegetable sponge, 8-15 parts of earthworm, 8-15 parts of ficus pumila, 6-10 parts of paris polyphylla, 6-10 parts of pawpaw, 8-15 parts of pangolin scales, 6-10 parts of Chinese tallowtree root-bark, 3-6 parts of cassia twig and 3-6 parts of stone ball. Clinical experiments prove that the medicine has the characteristics of good curative effect on accelerated hypertension and higher safety, and deserves clinical application and promotion.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of accelerated hypertension.
Background technology
Accelerated hypertension, is more common in middle-young patients, can develop by delaying into property hypertension, also can onset be malignant hypertension.Blood pressure significantly raises, more than diastolic pressure can reach 130mmhg.Rapidly, there is very soon albuminuria in its clinical manifestation progress, hematuria, and azotemia or uremia, occur that heart failure vision declines rapidly, in a short time without papilloedema.The pathogenesis of accelerated hypertension is very complicated, probably not normal relevant with the automatic regulation function of circulation, and relatively the theory of main flow has excessive adjusting or arteriolospasm theory, automatically regulates the theory of breaking.Concrete pathological manifestations is its intimal hyperplasia and fibrinoid necrosis.Pathological changes is mainly involved kidney and cerebrovascular, often causes kidney, brain generation ischemic necrosis and hemorrhage etc., grievous injury kidney, brain function.Patient dies from uremia, grievous injury kidney, cerebral hemorrhage or heart failure mostly.
The Therapeutic Principle of current clinical accelerated hypertension mostly is: reduce blood pressure rapidly, eliminate cerebral edema.The active remedies such as multiplex sodium nitroprusside or arfonad reduce blood pressure rapidly, once but the excessive or too fast hemoperfusion obstacle that easily causes again brain, the heart, kidney of blood pressure drops in therapeutic process, bring out myocardial infarction, cerebral infarction, even cause even more serious consequence.And it is unsatisfactory that active remedy maintains effect, easily cause fluctuation of blood pressure, hinder cerebrovascular autoregulation and recover adaptability.So clinical when carrying out the rapid depressurization of accelerated hypertension, the Chinese medicine of often arranging in pairs or groups carries out the assist control of blood pressure.
The hypertension secondary buck medicine of common clinical use mostly is suppressing the hyperactive liver to arrest the wind syndrome class medicine, as Cornu Saigae Tataricae, Carapax Eretmochelydis, Ramulus Uncariae Cum Uncis, Concha Haliotidis, and relieving spasm by subduing liver-wind class medicine, as Rhizoma Gastrodiae, Bombyx Batryticatus, Scorpio.But there is following defect in above therapeutic scheme treatment accelerated hypertension: 1. accelerated hypertension and hypertensive disease disunity, normally and suddenly there is accelerated hypertension symptom in some cases previously blood pressure, some drugs or food also can bring out accelerated hypertension in addition; 2. accelerated hypertension is not identical with hypertensive pathogenesis, and accelerated hypertension mostly is its intimal hyperplasia and fibrinoid necrosis; 3. a kind of as hypertensive emergency, clinical treatment quick venous channel and the rapid-action medicines of adopting carry out rapid depressurization more, if now re-use suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion, the drug effect stack with Western medicine in fact, make the more bad control of safe dose of the active remedies such as sodium nitroprusside or arfonad, the hemoperfusion obstacle that causes brain, the heart, kidney, brings out myocardial infarction, cerebral infarction; 4. accelerated hypertension is not normal relevant with the automatic regulation function of circulation, and this point is not all paid close attention in Western medicine and Chinese medicine treatment.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine of the sure treatment accelerated hypertension of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of accelerated hypertension, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Retinervus Luffae Fructuss, 8 ~ 15 parts of Pheretimas, 8 ~ 15 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 6 ~ 10 parts of Rhizoma Paridis, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Radix Cissi Kerrii, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts, stone gallbladder.
Its optimum weight proportioning is: 15 parts of Retinervus Luffae Fructuss, 10 parts of Pheretimas, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Radix Cissi Kerrii, 5 parts of Ramulus Cinnamomi, 5 parts, stone gallbladder.
Wherein said: Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.
Pheretima, is the dry body of Annelida Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, William Pheretimatschiliensis or comb the region between the heart and the diaphragm hair earthworm, and merit can heat clearing away, suppressing the hyperactive liver, Zhichuan, dredging collateral.
Caulis fici pumilae (Fructus Fici Pumilae) is stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) Ficus pumila L..Sour in the mouth, cool in nature.Enter kidney channel.Merit can expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.
Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship, is slightly cold.Slightly poisonous.Enter Liver Channel.Merit can heat-clearing and toxic substances removing, detumescence, spasmolytic.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa.Nature and flavor acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Radix Cissi Kerrii is the tuber of vitaceae Cissus repens Cissus modecoides Planch. var. subintegra Gagn..Bitter; Micro-pungent; Cool in nature.GUIXIN; Kidney channel.Merit can promoting blood circulation to remove obstruction in the collateral; Dissipating phlegm and resolving masses; Removing toxicity for eliminating carbuncles.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, pungent, cold.Removing the necrotic tissue; Removing toxic substances.
Composition principle: accelerated hypertension can not be equal to hypertension, the two course of disease disunity, normally and suddenly there is accelerated hypertension symptom in some cases previously blood pressure, some drugs or food also can bring out accelerated hypertension in addition.Accelerated hypertension is not identical with hypertensive pathogenesis, hypertension is mainly that the arterial wall that various neuro humor factors cause thickens, small artery shrinks, and accelerated hypertension is how relevant with its intimal hyperplasia and fibrinoid necrosis, some cases degree of cerebral edema and blood pressure are also not parallel.So accelerated hypertension Therapeutic Principle mostly be: reduce blood pressure rapidly, eliminate cerebral edema.But the target of accelerated hypertension treatment is not only to reduce blood pressure itself, the more important thing is sickness rate and the case fatality rate of overall reduction kidney, cerebrovascular.Concrete medication, the active remedies such as multiplex sodium nitroprusside or arfonad reduce blood pressure rapidly, once but the excessive or too fast hemoperfusion obstacle that easily causes again brain, the heart, brain, kidney of blood pressure drops in therapeutic process brings out myocardial infarction, cerebral infarction, even causes even more serious consequence.And it is unsatisfactory that active remedy maintains effect, easily cause fluctuation of blood pressure, hinder cerebrovascular autoregulation and recover adaptability.Therefore object of the present invention is exactly the rapid depressurization that coordinates Western medicine, plays following effect: 1. utilize the dual regulation of Chinese medicine, in secondary buck, prevent the untoward reaction of the excessive or too fast initiation of blood pressure drops; 2. recover the automatic regulation function of cerebral circulation; 3. protect the hemoperfusion of brain, the heart, kidney.
The present invention compared with the prior art, has following characteristics.
1, prescription is unique: for the pathogenesis that the automatic regulation function of accelerated hypertension cerebral circulation is unbalance, start with, dredging collateral dispels the wind, suppressing the hyperactive liver relaxing muscles and tendons, and assistant is with removing pathogenic heat from blood and toxic substance from the body.Prescription avoids using special blood circulation promoting medicine, as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Flos Carthami etc., because said medicine is too moved blood, easily adds the risk of cerebral hemorrhage; Avoid using the medicine of suppressing the hyperactive liver to arrest the wind syndrome, as Cornu Saigae Tataricae, Carapax Eretmochelydis, Ramulus Uncariae Cum Uncis etc., its reason is such medicine easily and the stack of the drug effect of Western medicine, makes the more bad control of safe dose of the active remedies such as sodium nitroprusside or arfonad; Avoid using YANG hyperactivity suppressing medicine, as Concha Haliotidis, SHENGLONGMU, Concha Margaritifera, Magnetitum etc., its reason is such medicine sinking gesture weight, coordinates quick-acting hypotensor to use, and easily causes cerebral hyoperfusion, causes cerebral infarction.
2, Retinervus Luffae Fructus, Pheretima, Caulis fici pumilae (Fructus Fici Pumilae) three herbal medicines share the merit that plays altogether dredging collateral, and so-called dredging collateral, for medicine channels helps the meaning of its operation; Dredging collateral medicine has logical extremity channels, Tongxinluo, logical liver and gall network, logical spleen kidney network etc., and Retinervus Luffae Fructus, the two property of medicine of Pheretima are frivolous, all walk women's head-ornaments and enter brain, so selecting this two medicine is monarch drug, and all right promoting blood circulation by removing wind of Retinervus Luffae Fructus, and Pheretima calming liver and clearing heat, clear sun rises turbid yin and falls; Caulis fici pumilae (Fructus Fici Pumilae) promoting blood circulation to remove obstruction in the collateral dehumidifies into kidney network, can effectively prevent the renal perfusion deficiency that excessive blood pressure lowering causes, and has reduced the risk of secondary renal failure.
3, supplementary drug thing: Rhizoma Paridis heat-clearing and toxic substances removing is got by side, all right spasmolytic of this medicine, contributes to control the appearance of epilepsy in addition; Fructus Chaenomelis suppressing the hyperactive liver relaxing muscles and tendons, can also alleviate due to accelerated hypertension cause nervous; It is strong that Squama Manis walks to alter power, enters liver stomach expel wind to dredge collateral; Radix Cissi Kerrii GUIXIN kidney channel, promoting blood circulation to remove obstruction in the collateral, can prevent heart, renal perfusion deficiency that excessive blood pressure lowering causes effectively.
4, using corrigent: the disease of excessive rising of liver-YANG is used Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, and activating YANG and prormoting functioning of QI, belongs to using corrigent, this using corrigent, except activating yang network, also has the meaning of pregnant sun in the moon.
5, stone gallbladder is aqueous sulfuric acid copper crystalline solid, in we, uses, and is to separate out copper ion in its decoction process, experiment showed, that copper ion can increase our drug effect.
6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Retinervus Luffae Fructus 10g, Pheretima 8g, Caulis fici pumilae (Fructus Fici Pumilae) 8g, Rhizoma Paridis 6g, Fructus Chaenomelis 6g, Squama Manis 8g, Radix Cissi Kerrii 6g, Ramulus Cinnamomi 3g, stone gallbladder 3g.
Embodiment 2, crude drug weight proportion: Retinervus Luffae Fructus 20g, Pheretima 15g, Caulis fici pumilae (Fructus Fici Pumilae) 15g, Rhizoma Paridis 10g, Fructus Chaenomelis 10g, Squama Manis 15g, Radix Cissi Kerrii 10g, Ramulus Cinnamomi 6g, stone gallbladder 6g.
Embodiment 3, crude drug weight proportion: Retinervus Luffae Fructus 15g, Pheretima 10g, Caulis fici pumilae (Fructus Fici Pumilae) 10g, Rhizoma Paridis 8g, Fructus Chaenomelis 8g, Squama Manis 10g, Radix Cissi Kerrii 8g, Ramulus Cinnamomi 5g, stone gallbladder 5g.
During use, Chinese medicine Retinervus Luffae Fructus of the present invention, Pheretima, Caulis fici pumilae (Fructus Fici Pumilae), Rhizoma Paridis, Fructus Chaenomelis, Squama Manis, Radix Cissi Kerrii, stone gallbladder, Ramulus Cinnamomi are decocted with water to twice, merging filtrate, a minute morning and evening takes.Or make the dosage forms such as oral liquid and use.
Effective combination of said medicine, coordinates mutually, can effectively reach the object for the treatment of accelerated hypertension, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 object: be that in January, a 2008 ~ 2011 year JIUYUE is made a definite diagnosis accelerated hypertension patient 42 examples, patient all meets accelerated hypertension diagnostic criteria, and the equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.Wherein, male 39 examples, female's 26 examples, 36 ~ 85 years old age, average 59.52 ± 17.11 years old.Essential hypertension 34 examples wherein, acute glomerulonephritis 8 examples.Before being admitted to hospital, the routine patient of essential hypertension 34 all intermittently took the depressor such as nifedipine, captopril, FUFANG LUOBUMA PIAN.
1.2 method.
1.2.1 research method: 42 routine patients are divided into matched group 22 example and experimental group 20 examples at random, and matched group gives Persistent low flow oxygen therapy, intravenous sodium nitroprusside reduction of blood pressure in high-speed, 20% mannitol quiet dehydration reduction intracranial pressure fast; Experimental group adds extract oral of the present invention on the basis for the treatment of of control group scheme.
1.2.2 efficacy determination assessment: curative effect is divided into effective, effective and invalid according to Ministry of Public Health < < clinical drug research guideline > > central vessel system clinical drug research guideline.Effective: diastolic pressure decline >20mmHg, clinical symptoms and sign are obviously improved; Effective: diastolic pressure decline 10 ~ 20mmHg, clinical symptoms and sign are partly improved; As for isolated systolic hypertension systolic pressure decline >=30mmHg be effective and effective; Invalid: not reach These parameters.
1.2.3 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.
1.2.4 statistical analysis: carry out statistical analysis with SPSS 13.0, P<0.05 indicates significant.
2 results.
2.1 therapeutic evaluatioies: after treatment 1d, two groups of all patient's blood pressures all start to decline, matched group total effective rate is 90.91%(20/22), treatment group total effective rate is 90.00%(18/20), two groups are compared no difference of science of statistics (P>0.05).Matched group 63.64%(14/22 after 3d) patient produces drug resistance to sodium nitroprusside, need to improve sodium nitroprusside maintenance dose, and treatment group only has 30%(6/20) patient there is sodium nitroprusside drug resistance and improve maintenance dose, two groups of comparing differences are (P<0.05) obviously.
2.2 untoward reaction: matched group adverse reaction rate is 22.72%(5/22), and treatment group is 10%(2/20), two groups of comparing differences obvious (P<0.05).
3. conclusion.
The prompting of this result of study, the present invention treats accelerated hypertension and has good effect and the higher feature of safety, clinic application, popularization.
Claims (1)
1. a medicine for the treatment of accelerated hypertension, is characterized in that, its composition of raw materials and weight proportion are: 15 parts of Retinervus Luffae Fructuss, 10 parts of Pheretimas, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Radix Cissi Kerrii, 5 parts of Ramulus Cinnamomi, 5 parts, stone gallbladder; Its preparation method is: Retinervus Luffae Fructus, Pheretima, Caulis fici pumilae (Fructus Fici Pumilae), Rhizoma Paridis, Fructus Chaenomelis, Squama Manis, Radix Cissi Kerrii, stone gallbladder, Ramulus Cinnamomi are decocted with water to twice, merging filtrate.
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| CN201210584739.2A CN103006996B (en) | 2012-12-31 | 2012-12-31 | Medicine for treating accelerated hypertension |
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| CN201210584739.2A CN103006996B (en) | 2012-12-31 | 2012-12-31 | Medicine for treating accelerated hypertension |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1724002A (en) * | 2005-07-13 | 2006-01-25 | 马淑珍 | Medicinal composition, and its pharmaceutical use |
| CN1857584A (en) * | 2006-03-14 | 2006-11-08 | 王信锁 | Hypertension treating Chinese medicine preparation |
| CN103006924A (en) * | 2012-12-31 | 2013-04-03 | 范丰双 | Medicine for treating hypertensive encephalopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1269515C (en) * | 2004-03-11 | 2006-08-16 | 胡廷俊 | A pharmaceutical composition for treating hypertension, externally applied paste and preparation method thereof |
| CN101229296A (en) * | 2007-01-23 | 2008-07-30 | 凌泰祥 | Medicine compounds for treating hypertension, heart disease and angina |
| CN101579492B (en) * | 2009-03-23 | 2011-08-24 | 路正平 | Medicine for treating high blood pressure and preparation method thereof |
| CN102727823B (en) * | 2012-06-08 | 2013-11-27 | 林明剑 | Medicine for postoperative rehabilitation of cerebral hemorrhage |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724002A (en) * | 2005-07-13 | 2006-01-25 | 马淑珍 | Medicinal composition, and its pharmaceutical use |
| CN1857584A (en) * | 2006-03-14 | 2006-11-08 | 王信锁 | Hypertension treating Chinese medicine preparation |
| CN103006924A (en) * | 2012-12-31 | 2013-04-03 | 范丰双 | Medicine for treating hypertensive encephalopathy |
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