CN103006997B

CN103006997B - Medicine for treating post-craniotomy headache

Info

Publication number: CN103006997B
Application number: CN201210584825.3A
Authority: CN
Inventors: 林明剑
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-31
Filing date: 2012-12-31
Publication date: 2014-03-26
Anticipated expiration: 2032-12-31
Also published as: CN103006997A

Abstract

The invention discloses a medicine for treating post-craniotomy headache to solve the problem of treatment of post-craniotomy headache. The medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of Chinese usnea, 8-15 parts of mosla chinensis maxim, 8-15 parts of herba sarcandrae, 6-10 parts of paris polyphylla, 6-10 parts of pawpaw, 8-15 parts of pangolin scales, 6-10 parts of largetrifoliolious bugbane rhizome, 3-6 parts of cassia twig and 3-6 parts of stone ball. Clinical experiments prove that the medicine has the characteristics of good curative effect on post-craniotomy headache and higher safety, and deserves clinical application and promotion.

Description

A kind of medicine for the treatment of post-craniotomy headache

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of post-craniotomy headache.

Background technology

Operation of opening cranium, also claims craniotomy, is that skull is operating a kind of, finger is opened patient's skull by plant equipment, thereby carries out some nonroutine treatments, due to the high risk of operation of opening cranium, for example doctor's operation error causes cerebral injury in patients, and this operation itself is also controversial.Yet for some special diseases, as parkinson disease, epilepsy etc., implement operation of opening cranium or necessary.

Post-craniotomy headache is the modal complication of post-craniotomy, is also the major issue that neurosurgeon faces.The patient of post-craniotomy headache is very painful, serious impact post-operative recovery.Post-craniotomy headache pathogenesis is still not clear at present, and some factors is probably not normal relevant with the automatic regulation function of cerebral circulation.

The solution of post-craniotomy headache has conservative treatment and invades therapy.Conservative treatment comprises analgesic, lies up and fluid-supplement therapy.Still the Chinese medicine that lacks at present the headache of special for treating post-craniotomy, clinical multiplex promoting flow of QI and blood class medicine, as Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Angelicae Sinensis, Flos Carthami etc., and relieving spasm by subduing liver-wind class medicine, as Rhizoma Gastrodiae, Bombyx Batryticatus, Scorpio are treated.But the headache of above therapeutic scheme treatment post-craniotomy exists following defect: 1. post-craniotomy headache is not identical with angioneurotic headache pathogenesis, how open with cranial cavity post-craniotomy headache is, the forfeiture of cerebrospinal fluid is not normal relevant with the automatic regulation function of cerebral circulation; 2. use promoting flow of QI and blood class, relieving spasm by subduing liver-wind class medicine, in part situation, have and conflict with protopathy operation; 3. post-craniotomy headache is not normal relevant with the automatic regulation function of cerebral circulation, and this point is not all paid close attention in Western medicine and Chinese medicine treatment.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine of the sure treatment post-craniotomy headache of a kind of curative effect is provided.

The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of post-craniotomy headache, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Spilanthis Acmellae, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Rhizoma Paridis, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts, stone gallbladder.

Its optimum weight proportioning is: 15 parts of Usneas, 10 parts of Herba Spilanthis Acmellae, 10 parts of Herba Sarcandraes, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts, stone gallbladder.

Wherein said: Usnea is the thallus (thallus) of Usneaceae Usnea plant USNEA Usnea diffracta (female trailing plants, Herba Cucubali) Usnea diffracta Vain. or Usnea Longissima (Scolopendra Usnea, Herba Stellariae Alsines) U. longissima Ach..Nature and flavor are sweet, flat.Merit can heat-clearing and toxic substances removing, hemostasia and promoting granulation, and pain relieving, liver heat removing and eyesight improving, moves back nebula.

Herba Spilanthis Acmellae is the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature.Merit can relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.

Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, pungent, flat.GUIXIN, Liver Channel.Merit can clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.

Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship, is slightly cold.Slightly poisonous.Enter Liver Channel.Merit can heat-clearing and toxic substances removing, detumescence, spasmolytic.

Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa.Nature and flavor acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.

Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.

Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.

Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, pungent, cold.Removing the necrotic tissue; Removing toxic substances.

Composition principle: post-craniotomy headache is not identical with angioneurotic headache pathogenesis, how open with cranial cavity post-craniotomy headache is, the forfeiture of cerebrospinal fluid is not normal relevant with the automatic regulation function of cerebral circulation.Therefore object of the present invention is: 1. utilize the dual regulation of Chinese medicine, recover the automatic regulation function of cerebral circulation; 2. protect the hemoperfusion of brain.

The present invention compared with the prior art, has following characteristics.

1, prescription is unique: the unbalance pathogenesis of automatic regulation function for post-craniotomy headache cerebral circulation is started with, and dredging collateral dispels the wind, suppressing the hyperactive liver relaxing muscles and tendons, and assistant is with removing pathogenic heat from blood and toxic substance from the body.Prescription avoids using special blood circulation promoting medicine, as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Flos Carthami etc., because said medicine is too moved blood, easily strengthens the risk of postoperative hemorrhage; Avoid using the medicine of suppressing the hyperactive liver to arrest the wind syndrome YANG hyperactivity suppressing, as Cornu Saigae Tataricae, Carapax Eretmochelydis, Ramulus Uncariae Cum Uncis, Concha Haliotidis, SHENGLONGMU, Concha Margaritifera, Magnetitum etc., its reason is such medicine sinking gesture weight, easily causes cerebral hyoperfusion, causes transient cerebral ischemia.

2, Usnea, Herba Spilanthis Acmellae, Herba Sarcandrae three herbal medicines share the merit that plays altogether regulating qi and dredging collateral, regulate the flow of vital energy different from circulation of qi promoting, without the anxiety of dissipation, so-called dredging collateral, for medicine channels helps the meaning of its operation; Dredging collateral medicine has logical extremity channels, Tongxinluo, logical liver and gall network, logical spleen kidney network etc., and Usnea, the two property of medicine of Herba Spilanthis Acmellae are frivolous, all walking women's head-ornaments and enter brain, is monarch drug so select this two medicine, and inventor's clinical research is for many years found, Herba Spilanthis Acmellae can pass through blood brain barrier, enter maincenter, reach the object of reducing swelling and alleviating pain, but the headache producing for post-craniotomy there is special effect, coordinate the liver heat removing pain relieving of Usnea, amount to sun clearly and rise the merit that turbid yin falls; Herba Sarcandrae clearing away heat and cooling blood, the speckle removing of invigorating blood circulation enters brain network, can effectively prevent from excessively regulating the brain hypoperfusion causing.

3, supplementary drug thing: Rhizoma Paridis heat-clearing and toxic substances removing is got by side, all right spasmolytic of this medicine, contributes to control the appearance of epilepsy in addition; Fructus Chaenomelis suppressing the hyperactive liver relaxing muscles and tendons, can also alleviate due to post-craniotomy headache cause nervous; It is strong that Squama Manis walks to alter power, enters liver stomach expel wind to dredge collateral; Rhizoma Cimicifugae elevate a turnable ladder yang-energy, can prevent from excessively regulating the cerebral hyoperfusion causing effectively.

4, using corrigent: the disease of excessive rising of liver-YANG is used Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, and activating YANG and prormoting functioning of QI, belongs to using corrigent, this using corrigent, except activating yang network, also has the meaning of pregnant sun in the moon.

5, stone gallbladder is aqueous sulfuric acid copper crystalline solid, in we, uses, and is to separate out copper ion in its decoction process, experiment showed, that copper ion can increase our drug effect.

6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: Usnea 10g, Herba Spilanthis Acmellae 8g, Herba Sarcandrae 8g, Rhizoma Paridis 6g, Fructus Chaenomelis 6g, Squama Manis 8g, Rhizoma Cimicifugae 6g, Ramulus Cinnamomi 3g, stone gallbladder 3g.

Embodiment 2, crude drug weight proportion: Usnea 20g, Herba Spilanthis Acmellae 15g, Herba Sarcandrae 15g, Rhizoma Paridis 10g, Fructus Chaenomelis 10g, Squama Manis 15g, Rhizoma Cimicifugae 10g, Ramulus Cinnamomi 6g, stone gallbladder 6g.

Embodiment 3, crude drug weight proportion: Usnea 15g, Herba Spilanthis Acmellae 10g, Herba Sarcandrae 10g, Rhizoma Paridis 8g, Fructus Chaenomelis 8g, Squama Manis 10g, Rhizoma Cimicifugae 8g, Ramulus Cinnamomi 5g, stone gallbladder 5g.

During use, Chinese medicine Usnea of the present invention, Herba Spilanthis Acmellae, Herba Sarcandrae, Rhizoma Paridis, Fructus Chaenomelis, Squama Manis, Rhizoma Cimicifugae, stone gallbladder, Ramulus Cinnamomi are decocted with water to twice, merging filtrate, a minute morning and evening takes.Or make the dosage forms such as oral liquid and use.

Effective combination of said medicine, coordinates mutually, can effectively reach the object for the treatment of post-craniotomy headache, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is the crude drug weight proportion in embodiment 3.

1 object and method.

1.1 objects: be in January, 2008 ~ 2011 year JIUYUE row post-craniotomy complicated by postoperative headache 42 examples, patient all meets post-craniotomy headache diagnoses standard, and the equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.Wherein, male 39 examples, female's 26 examples, 12 ~ 71 years old age, average 39.52 ± 11.11 years old.Classification of diseases: intracranial tumor 27 examples, cerebral trauma 4 examples, hypertensive cerebral hemorrhage 4 examples, lopsided 3 examples are rested the head in extensive region, arachnoid cyst 3 examples, cerebrovascular malformation 1 example.

1.2 method.

1.2.1 research method: 42 routine patients are divided into matched group 22 example and experimental group 20 examples at random, and it is oral that matched group gives ibuprofen; Experimental group gives the embodiment of the present invention 3 gained extract orals.

1.2.2 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.

1.2.3 statistical analysis: carry out statistical analysis with SPSS 13.0, P<0.05 indicates significant.

2 results.

2.1 therapeutic evaluatioies: after treatment 1d, matched group total effective rate is 22.72%(5/22), treatment group total effective rate is 65.00%(13/20), two groups of comparing differences are (P<0.01) very obviously.After 3d, matched group total effective rate is 63.64%(14/22), treatment group total effective rate is 90.00%(18/20), two groups of comparing differences are (P<0.01) very obviously.

2.2 untoward reaction: two groups all do not occur obvious adverse reaction.

3. conclusion.

The prompting of this result of study, the present invention treats post-craniotomy headache and has good effect and the higher feature of safety, clinic application, popularization.

Claims

1. treat the medicine that post-craniotomy is had a headache for one kind, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Spilanthis Acmellae, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Rhizoma Paridis, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts, stone gallbladder.

2. a kind of medicine for the treatment of post-craniotomy headache according to claim 1, is characterized in that its weight proportion is: 15 parts of Usneas, 10 parts of Herba Spilanthis Acmellae, 10 parts of Herba Sarcandraes, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts, stone gallbladder.