CN103006997A

CN103006997A - Medicine for treating post-craniotomy headache

Info

Publication number: CN103006997A
Application number: CN2012105848253A
Authority: CN
Inventors: 林明剑
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-31
Filing date: 2012-12-31
Publication date: 2013-04-03
Anticipated expiration: 2032-12-31
Also published as: CN103006997B

Abstract

The invention discloses a medicine for treating post-craniotomy headache to solve the problem of treatment of post-craniotomy headache. The medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of Chinese usnea, 8-15 parts of mosla chinensis maxim, 8-15 parts of herba sarcandrae, 6-10 parts of paris polyphylla, 6-10 parts of pawpaw, 8-15 parts of pangolin scales, 6-10 parts of largetrifoliolious bugbane rhizome, 3-6 parts of cassia twig and 3-6 parts of stone ball. Clinical experiments prove that the medicine has the characteristics of good curative effect on post-craniotomy headache and higher safety, and deserves clinical application and promotion.

Description

A kind of medicine for the treatment of the post-craniotomy headache

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of the post-craniotomy headache.

Background technology

Operation of opening cranium also claims craniotomy, is that skull is operating a kind of, finger is opened patient's skull by plant equipment, thereby carries out some nonroutine treatments, because the high risk of operation of opening cranium, for example doctor's operation error causes cerebral injury in patients, and this operation itself is also controversial.Yet for some special diseases, such as parkinson disease, epilepsy etc., implement operation of opening cranium or necessary.

The post-craniotomy headache is the modal complication of post-craniotomy, also is the major issue that neurosurgeon faces.The patient of post-craniotomy headache is very painful, has seriously influenced post-operative recovery.Post-craniotomy headache pathogenesis is still not clear at present, and some factors is probably not normal relevant with the automatic regulation function of cerebral circulation.

The solution of post-craniotomy headache has conservative treatment and invades therapy.Conservative treatment comprises analgesic, lies up and fluid-supplement therapy.Still the Chinese medicine that lacks at present the headache of special for treating post-craniotomy, clinical multiplex promoting flow of QI and blood class medicine, such as Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, the Radix Angelicae Dahuricae, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Angelicae Sinensis, Flos Carthami etc., and relieving spasm by subduing liver-wind class medicine, treat such as Rhizoma Gastrodiae, Bombyx Batryticatus, Scorpio.But there is following defective in the headache of above therapeutic scheme treatment post-craniotomy: 1. the post-craniotomy headache is not identical with the angioneurotic headache pathogenesis, and the post-craniotomy headache is many to be opened with cranial cavity, the automatic regulation function of the forfeiture of cerebrospinal fluid and cerebral circulation is not normal relevant; 2. use promoting flow of QI and blood class, relieving spasm by subduing liver-wind class medicine, have with protopathy operation in the part situation and conflict; 3. the post-craniotomy headache is not normal relevant with the automatic regulation function of cerebral circulation, and this point is not all paid close attention in Western medicine and Chinese medicine treatment.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine of the sure treatment post-craniotomy headache of a kind of curative effect is provided.

The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of the post-craniotomy headache, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Spilanthis Acmellae, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Rhizoma Paridis, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts in stone gallbladder.

Its optimum weight proportioning is: 15 parts of Usneas, 10 parts of Herba Spilanthis Acmellae, 10 parts of Herba Sarcandraes, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts in stone gallbladder.

Wherein said: Usnea is the thallus (thallus) of Usneaceae Usnea plant USNEA Usnea diffracta (women trailing plants, Herba Cucubali) Usnea diffracta Vain. or Usnea Longissima (Scolopendra Usnea, Herba Stellariae Alsines) U. longissima Ach..Nature and flavor are sweet, and are flat.But the merit heat-clearing and toxic substances removing, hemostasia and promoting granulation, pain relieving, liver heat removing and eyesight improving moves back nebula.

Herba Spilanthis Acmellae is the herb of feverfew Herba Cancriniae lasiocarpae Spilanthes paniculata Wall.ex DC..Acrid in the mouth; Bitter; Slightly warm in nature.But merit relieving cough and asthma; Detoxification and promoting urination; Reducing swelling and alleviating pain.

Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, hot, flat.GUIXIN, Liver Channel.But the merit clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.

Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship is slightly cold.Slightly poisonous.Enter Liver Channel.But the merit heat-clearing and toxic substances removing, detumescence, spasmolytic.

Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa.Nature and flavor acid, temperature.Return liver, spleen channel.But merit suppressing the hyperactive liver Shujin, the stomach function regulating removing dampness.

Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.

Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are hot, little sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor are hot, sweet, temperature.Enter the heart, lung, urinary bladder channel.But the merit relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.

The stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, hot, cold.Removing the necrotic tissue; Detoxifcation.

Composition principle: post-craniotomy headache is not identical with the angioneurotic headache pathogenesis, and many forfeiture and the automatic regulation functions of cerebral circulation with cranial cavity opening, cerebrospinal fluid of post-craniotomy headache are not normal relevant.So purpose of the present invention is: 1. utilize the dual regulation of Chinese medicine, recover the automatic regulation function of cerebral circulation; 2. protect the hemoperfusion of brain.

The present invention has following characteristics compared with the prior art.

1, prescription is unique: the unbalance pathogenesis of automatic regulation function for post-craniotomy headache cerebral circulation is started with, and collateral dredging dispels the wind, the suppressing the hyperactive liver Shujin, and assistant is with removing pathogenic heat from blood and toxic substance from the body.Prescription avoids using special blood circulation promoting medicine, such as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Flos Carthami etc., because said medicine is too moved blood, strengthens easily the risk of postoperative hemorrhage; Avoid using the medicine of suppressing the hyperactive liver to arrest the wind syndrome YANG hyperactivity suppressing, such as Cornu Saigae Tataricae, Carapax Eretmochelydis, Ramulus Uncariae Cum Uncis, Concha Haliotidis, SHENGLONGMU, Concha Margaritifera, Magnetitum etc., its reason is that such medicine sinking gesture is heavy, causes easily cerebral hyoperfusion, causes transient cerebral ischemia.

2, Usnea, Herba Spilanthis Acmellae, Herba Sarcandrae three herbal medicines share the merit that plays altogether regulating qi and dredging collateral, and it is different from circulation of qi promoting to regulate the flow of vital energy, and without the anxiety of dissipation, so-called collateral dredging, help the meaning of its operation for the medicine channels; The collateral dredging medicine has logical extremity channels, Tongxinluo, logical liver and gall network, logical spleen kidney network etc., and Usnea, the two property of medicine of Herba Spilanthis Acmellae are frivolous, all walking women's head-ornaments and enter brain, is monarch drug so select this two medicine, and for many years clinical research of inventor is found, Herba Spilanthis Acmellae can pass through blood brain barrier, enter maincenter, reach the purpose of reducing swelling and alleviating pain, but the headache that produces for post-craniotomy there is special effect, cooperate the liver heat removing pain relieving of Usnea, amounting to clearly, sun rises the merit that turbid yin falls; The Herba Sarcandrae clearing away heat and cooling blood, the speckle removing of invigorating blood circulation enters the brain network, can effectively prevent from excessively regulating the brain hypoperfusion that causes.

3, supplementary drug thing: the Rhizoma Paridis heat-clearing and toxic substances removing is got by the side, and all right spasmolytic of this medicine helps to control the appearance of epilepsy in addition; Fructus Chaenomelis suppressing the hyperactive liver Shujin can also be alleviated because that post-craniotomy headache causes is nervous; It is strong that Squama Manis walks to alter power, enters liver stomach expel wind to dredge collateral; Rhizoma Cimicifugae elevate a turnable ladder yang-energy can prevent from excessively regulating the cerebral hyoperfusion that causes effectively.

4, using corrigent: the disease of excessive rising of liver-YANG is used the Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, and activating YANG and prormoting functioning of QI belongs to using corrigent, and this using corrigent also has the meaning of pregnant sun in the moon except the network that activates yang.

5, the stone gallbladder is aqueous sulfuric acid copper crystalline solid, uses among the we, is to separate out copper ion in its decoction process, experiment showed, that copper ion can increase our drug effect.

6, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have preferably curative effect in the following weight parts scope.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, the crude drug weight proportion: Usnea 10g, Herba Spilanthis Acmellae 8g, Herba Sarcandrae 8g, Rhizoma Paridis 6g, Fructus Chaenomelis 6g, Squama Manis 8g, Rhizoma Cimicifugae 6g, Ramulus Cinnamomi 3g, stone gallbladder 3g.

Embodiment 2, the crude drug weight proportion: Usnea 20g, Herba Spilanthis Acmellae 15g, Herba Sarcandrae 15g, Rhizoma Paridis 10g, Fructus Chaenomelis 10g, Squama Manis 15g, Rhizoma Cimicifugae 10g, Ramulus Cinnamomi 6g, stone gallbladder 6g.

Embodiment 3, the crude drug weight proportion: Usnea 15g, Herba Spilanthis Acmellae 10g, Herba Sarcandrae 10g, Rhizoma Paridis 8g, Fructus Chaenomelis 8g, Squama Manis 10g, Rhizoma Cimicifugae 8g, Ramulus Cinnamomi 5g, stone gallbladder 5g.

During use, Chinese medicine Usnea of the present invention, Herba Spilanthis Acmellae, Herba Sarcandrae, Rhizoma Paridis, Fructus Chaenomelis, Squama Manis, Rhizoma Cimicifugae, stone gallbladder, Ramulus Cinnamomi are decocted with water twice, merging filtrate, a minute morning and evening takes.Or make the dosage form such as oral liquid and use.

Effective combination of said medicine is coordinated mutually, can effectively reach the purpose for the treatment of post-craniotomy headache, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses and is the crude drug weight proportion among the embodiment 3.

1 object and method.

1.1 object: be in January, 2008 ~ 2011 year JIUYUE row post-craniotomy complicated by postoperative headache 42 examples, the patient all meets post-craniotomy headache diagnoses standard, and the equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.Wherein, male 39 examples, women 26 examples, 12 ~ 71 years old age, average 39.52 ± 11.11 years old.Classification of diseases: intracranial tumor 27 examples, cerebral trauma 4 examples, hypertensive cerebral hemorrhage 4 examples, lopsided 3 examples are rested the head in the extensive region, arachnoid cyst 3 examples, cerebrovascular malformation 1 example.

1.2 method.

1.2.1 research method: 42 routine patients are divided into matched group 22 example and experimental group 20 examples at random, and it is oral that matched group gives ibuprofen; Experimental group gives the embodiment of the invention 3 gained extract orals.

1.2.2 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after the medication.

1.2.3 statistical analysis: carry out statistical analysis with SPSS 13.0, P＜0.05 expression has significant.

2 results.

2.1 therapeutic evaluation: behind treatment 1d, the matched group total effective rate is 22.72%(5/22), the treatment group total effective rate is 65.00%(13/20), two groups of comparing differences are (P＜0.01) very obviously.Behind the 3d, the matched group total effective rate is 63.64%(14/22), the treatment group total effective rate is 90.00%(18/20), two groups of comparing differences are (P＜0.01) very obviously.

2.2 untoward reaction: two groups obvious adverse reaction all do not occur.

3. conclusion.

The prompting of this result of study, the present invention are treated the post-craniotomy headache and are had good effect and the higher characteristics of safety, and clinic is used, promoted.

Claims

1. treat the medicine that post-craniotomy is had a headache for one kind, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Moslae Chinensis, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Rhizoma Paridis, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts in stone gallbladder.

2. a kind of medicine for the treatment of the post-craniotomy headache according to claim 1 is characterized in that its weight proportion is: 15 parts of Usneas, 10 parts of Herba Moslae Chinensis, 10 parts of Herba Sarcandraes, 8 parts of Rhizoma Paridis, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts in stone gallbladder.