CN101254272B

CN101254272B - Medicament for promoting coronary circulation and embolism resistance

Info

Publication number: CN101254272B
Application number: CN2008100547963A
Authority: CN
Inventors: 李四牛; 曹润莲
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-04-12
Filing date: 2008-04-12
Publication date: 2010-12-22
Anticipated expiration: 2028-04-12
Also published as: CN101254272A

Abstract

The invention relates to the field of Chinese herbal medicine, in particular to a drug for activating blood circulation, dredging vessels and anti-thrombosis, which can solve the problems of great side effects, long administration time and low efficiency of the prior anti-thrombosis western drugs and unreasonable compatibility and poor efficacy etc. of the traditional Chinese medicines, the drug is prepared by Chinese angelica, Szechuan lovage rhizome, white paeony root, earthworm, membranous milkvetch root, safflower, peach seed, red paeony root, dwarf lilyturf tuber, ginseng, dried rehmannia root and Chinese magnoliavine fruit for the treatment of mild thrombotic diseases, leech, danshen root, garter snake, pangolin scales, glabrous greenbrier rhizome and liquoric root are increased on the basis of the medicines for the treatment of severe thrombotic diseases, the medicines are combined for usage and mutual promotion and have the effects of improving microcirculation, reducing blood viscosity, expanding arterial blood vessels, promoting blood circulation, inhibiting thrombus formation, improving brain blood supply and protecting brain cells, so the drug is the better drug for the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, cerebral embolism and other diseases and can carry out the targeted treatment of mild and severe thrombotic diseases with short administration time, good efficacy and no toxicity or side effects.

Description

A kind of medicine of promoting coronary circulation and embolism resistance

Technical field

The present invention relates to field of Chinese herbal, be specially a kind of medicine of promoting coronary circulation and embolism resistance.

Background technology

Thrombotic disease is one of disease of serious harm human health, has the sickness rate height, the disability rate height, the mortality rate height, characteristics such as relapse rate height, the branch that slight and severe are arranged, such as venous thrombosis, varicosis etc., the purpose of this stage treatment is prevention and control complication, if it is improper to prevent, then can cause acute ischemia cardio-cerebrovascular diseases, coronary heart disease, hypertension, angina pectoris, cerebral embolism, diseases such as cerebral vasospasm, belong to severe, it is reported that cerebrovascular disease is one of old people's three big causes of death, wherein the acute ischemic cerebrovascular disease disease accounts for the 43-65% of cerebrovascular, and case fatality rate is 15-25%.

Present antithrombotic medicine mostly is Western medicine greatly, such as warfarin, though determined curative effect, can reduce blood viscosity, expansion artery blood vessel, blood circulation promoting, inhibition thrombosis, but untoward reaction is obvious, and it is very big to take side effect for a long time, as hemorrhage, tired, drowsiness, vomiting, feel sick, and drug dependence is big, administration time is long, effective percentage is low, above-mentioned drawbacks limit its life-time service clinically.China's Chinese medicine studies show that, Chinese medicine with blood circulation promoting and blood stasis dispelling or regulating the flow of QI to dissipate blood stasis effect has different adjusting endotheliocyte anti thrombotic actions, the natural Chinese medicinal herb safety is good, oral effectively, therefore the antithrombotic reagent that develops pure natural is an effective way of developing novel antithrombotic reagent at present, that but antithrombotic raw material of Chinese medicine is in the market chosen is unreasonable, compatibility is improper, and do not suit the remedy to the case for slight and severe thrombotic disease, just take by survival dose simply, cause its curative effect relatively poor.

Summary of the invention

The present invention exists in order to solve existing embolism resistance Western medicine that side effect is big, administration time is long, effective percentage is low; And Chinese medicine exists problems such as compatibility is unreasonable, weak curative effect provide a kind of medicine of promoting coronary circulation and embolism resistance.

The present invention adopts following technical scheme to realize: a kind of medicine of promoting coronary circulation and embolism resistance, and make raw materials of effective components and comprise: Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Paeoniae Alba 5-10 part, Pheretima 5-8 part, Radix Astragali 55-65 part, Flos Carthami 10-15 part, Semen Persicae 10-15 part, Radix Paeoniae Rubra 10-12 part, Radix Ophiopogonis 15-25 part, Radix Ginseng 5-10 part, Radix Rehmanniae 20-25 part, Fructus Schisandrae Chinensis 10-20 part.This medicine is aimed at slight thrombotic disease such as venous thrombosis, varicosis, chronic cardiovascular and cerebrovascular disease etc., has good blood circulation and channel invigorating effect.

For the severe thrombotic disease, the present invention has increased following raw material on the basis of above-mentioned prescription: Hirudo 10-15 part, Radix Salviae Miltiorrhizae 10-18 part, Zaocys 10-20 part, Squama Manis 12-15 part, Rhizoma Smilacis Glabrae 15-18 part, Radix Glycyrrhizae 8-10 part.

The preparation method of medicine of the present invention is as follows: every flavor medicine all (answers wine to fry such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra according to standards of pharmacopoeia and the processing of Chinese medicine processing standard, the Radix Astragali is answered processed with honey, the Radix Rehmanniae is answered wine processing, Fructus Schisandrae Chinensis should be fried) after, entry was soaked 15-20 minute, boiled with big fire then, the little fire of reuse fried 30-40 minute, filter medicinal liquid, promptly can be made into various dosage forms, as capsule, tablet, powder, pill.

In the said medicine: Radix Angelicae Sinensis: property is sweet, hot, and temperature is enriched blood and invigorated blood circulation, and menstruction regulating and pain relieving cures mainly blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow; Rhizoma Chuanxiong: the property suffering, temperature, blood-activating and qi-promoting, wind-expelling pain-stopping, activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, tumbling and swelling, rheumatic arthralgia; The Radix Paeoniae Alba: the property picric acid, cold, nourishing blood to suppress the hyperactive liver, slow in pain relieving, yin fluid astringing is received antiperspirant, controls the breast abdomen pain over the hypochondriac region, spontaneous sweating, fever due to yin deficiency is a coronary artery dilator to the effect of cardiovascular system, brings high blood pressure down; Pheretima: property is salty-cold, heat clearing away, and spasmolytic, detoxifcation cures mainly calentura mania and irritation, infantile convulsion, Fengshi Guanjie pain, diseases such as hemiplegia; The Radix Astragali: nature and flavor are sweet, temperature, and invigorating QI to consolidate the body surface resistance is used for weak, the sinking of QI of middle-JIAO of the deficiency of vital energy, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Flos Carthami: warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain are used for that lochia is not all right, lump in the abdomen mass in the abdomen, traumatic injury; Semen Persicae: property is flat, bitter in the mouth, sweet, blood circulation promoting and blood stasis dispelling, Yong Yu WEIJIA mass in the abdomen, injury from falling down; Radix Paeoniae Rubra: the property hardship, be slightly cold, clearing away heat and cooling blood, eliminating stasis to stop pain is used for the blood system excess-heat, hematemesis and epistaxis, conjunctival congestion and swelling pain, injury from falling down is good at promoting blood circulation to remove blood stasis; Radix Ophiopogonis: sweet, the little hardship of property, be slightly cold, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and is used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, pharyngeal diphtheria; Radix Ginseng: sweet, the little hardship of property, flat, strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves, and is used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, heart failure, cardiogenic shock; The Radix Rehmanniae: property is sweet, bitter, cold, clearing away heat and cooling blood, and yin nourishing is promoted the production of body fluid, and is used for interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood epistaxis; Fructus Schisandrae Chinensis: property acid, temperature is astringed the lung, and nourishing kidney is promoted the production of body fluid, and cures mainly chronic cough of deficiency lung, and lung is suffered from a deficiency of the kidney and is breathed heavily, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, spontaneous sweating, palpitation and insomnia, dreaminess is forgetful; Hirudo: the salty hardship of property, flat, poisonous, stimulate the menstrual flow the removing blood stasis with potent drugs detumescence.Cure mainly diseases such as traumatic blood stasis is had a pain, carbuncle erysipelas, blood-retention, lump in the abdomen gathers, and blood stasis becomes consumptive disease, injury from falling down; Radix Salviae Miltiorrhizae: the property hardship, be slightly cold, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire is used for lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris; Zaocys: property is sweet, and is flat, dispel the wind, and collateral dredging, relieving convulsion is used for rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm; Squama Manis: property is salty, is slightly cold, the stimulating milk secretion of stimulating the menstrual flow, and detumescence and apocenosis, expel wind to dredge collateral is used for carbuncle sore tumefacting virus, arthralgia, numbness contracture; Rhizoma Smilacis Glabrae: property is flat, sweet in the mouth, and dehumidifying, detoxifcation, easing joint movement is used for muscles and bones contracture pain, scrofula, skin infection; Radix Glycyrrhizae: sweet, flat, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, the anxious pain of extremity contraction, carbuncle sore tumefacting virus.

All medicines are used in combination; mutually promote; has the hemodynamic of improvement; microcirculation improvement; reduce blood viscosity; increase erythrocyte deformability; can the expansion artery blood vessel; blood circulation promoting; suppress thrombosis and improve the cerebral tissue blood supply; the protection brain cell; for urgency; CCVD all has good curative effect; be to be used for the treatment of ischemic cardio cerebrovascular diseases; coronary heart disease; cerebral embolism; the better medicine of diseases such as cerebral vasospasm; and treat targetedly for slight and severe embolization disease, administration time is lacked; good effect; without any side effects.Through 150 patients are treated, the statistics effect is as follows:

Age bracket	The example number	Disease	Cure routine number	Cure rate
					40-55	85	Venous thrombosis, chronic ischemic cerebrovascular, coronary heart disease, angina pectoris	79	93％
55-85	65	Acute ischemia cardio-cerebrovascular diseases, cerebral embolism, apoplexy, coronary heart disease, hypertension	55	84％

Medicine of the present invention can reach more than 90% for the effective percentage of slight thrombotic disease, plays excellent prevention and control action, can reach more than 80% for the effective percentage of severe thrombotic disease.

Model case:

1, Ms Zhang, 45 years old, the patient had hypertension for many years, normal feel sleep at uncomfortable in chest, cardiopalmus, night peaceful, have a dizzy spell, the dimness of vision, be diagnosed as the bilateral ocular fundus arteriosclerosis, take medicine of the present invention after 20 days, all diseases are clearly better, and electrocardiogram is roughly normal, and stride is strong, vision is got better.

2, Mr. Liu, 50 years old, conscious limbs one side reaction paused late, numbness, unusual, the instep edema, and the pain increased when walking, is diagnosed as thromboangiitis, takes medicine of the present invention after 2 months, and the instep edema disappears, pain relief, after continuing to take two weeks, pain disappears, and walking is freely.

3, Mr. Wang, 70 years old,, show as confused servant, hemiplegia, crooked mouth and tongue, slurred speech, aphasia because of apoplexy burst cerebral hemorrhage, be diagnosed as ischemic cardio cerebrovascular diseases, take medicine of the present invention after 1 month, mind is gradually clear, and brothers change temperature, also can stretch in the wrong, after continuing to take the medicine two weeks, all diseases disappear, and also can walk with descending.

4, Mr. Li 65 years old, suffers from coronary heart disease for many years, show as various arrhythmia such as atrial fibrillation, chamber morning, atrioventricular block in early days, symptom such as tachypnea, nocturnal paroxysmal dyspnea is not after hospitalize has any improvement, after symptoms such as ictal chest pain or chest discomfort often appear again, after taking medicine of the present invention, myocardial oxygen delivery blood supply balance, electrocardiogram is normal, breathe smooth and easy, symptoms such as no chest pain, chest discomfort.

5, Mr. Pang, 75 years old, because of pulmonary infarction, began before a week, apoplexy due to phlegm has blood, breathes out blood subsequently and often takes place, and amount is big, out of breath, can not put down for sleeping inly, perspire, dizzy, arrhythmia, take medicine of the present invention after two weeks, symptom alleviates to some extent, after continuing to take one month, all diseases disappear, all rehabilitations.

The specific embodiment

Embodiment 1: every part is 1 gram

A kind of medicine of promoting coronary circulation and embolism resistance is made raw materials of effective components and is comprised: Radix Angelicae Sinensis 10 grams, Rhizoma Chuanxiong 10 grams, the Radix Paeoniae Alba 5 grams, Pheretima 5 grams, the Radix Astragali 55 grams, Flos Carthami 10 grams, Semen Persicae 10 grams, Radix Paeoniae Rubra 10 grams, restrain Radix Ophiopogonis 15, Radix Ginseng 5 grams, the Radix Rehmanniae 20 grams, Fructus Schisandrae Chinensis 10 grams mix the back entry with above-mentioned all medicines and soaked 20 minutes, boil with big fire then, fried 30 minutes of the little fire of reuse, filter medicinal liquid, make capsule, be used for the treatment of slight thrombotic disease, such as phlebothrombosis.

Embodiment 2: 1 jin every part

A kind of medicine of promoting coronary circulation and embolism resistance is made raw materials of effective components and is comprised: 20 jin of Radix Angelicae Sinensis, 20 jin of Rhizoma Chuanxiongs, 10 jin of the Radix Paeoniae Albas, 8 jin of Pheretimas, 65 jin of the Radixs Astragali, 15 jin on Flos Carthami, 15 jin in Semen Persicae, 12 jin of Radix Paeoniae Rubra, 25 jin of Radix Ophiopogonis, 10 jin of Radix Ginsengs, 25 jin in the Radix Rehmanniae, 20 jin of Fructus Schisandrae Chinensis, 15 jin of Hirudos, 18 jin of Radix Salviae Miltiorrhizaes, 20 jin of Zaocyss, 15 jin of Squama Maniss, 18 jin of Rhizoma Smilacis Glabraes, 10 jin in Radix Glycyrrhizae, above-mentioned all medicines are mixed the back entry soaked 15 minutes, boil fried 40 minutes of the little fire of reuse then with big fire, filter medicinal liquid, make tablet, be used for the treatment of the severe thrombotic disease, as acute ischemia cardio-cerebrovascular diseases.

Embodiment 3: 1 kilogram every part

A kind of medicine of promoting coronary circulation and embolism resistance is made raw materials of effective components and is comprised: 20 kilograms of Radix Angelicae Sinensis, 10 kilograms of Rhizoma Chuanxiongs, 5 kilograms of the Radix Paeoniae Albas, 8 kilograms of Pheretimas, 60 kilograms of the Radixs Astragali, 12 kilograms on Flos Carthami, 10 kilograms in Semen Persicae, 12 kilograms of Radix Paeoniae Rubra, 18 kilograms of Radix Ophiopogonis, 8 kilograms of Radix Ginsengs, 25 kilograms in the Radix Rehmanniae, 15 kilograms of Fructus Schisandrae Chinensis, 10 kilograms of Hirudos, 15 kilograms of Radix Salviae Miltiorrhizaes, 12 kilograms of Zaocyss, 12 kilograms of Squama Maniss, 18 kilograms of Rhizoma Smilacis Glabraes, 9 kilograms in Radix Glycyrrhizae, above-mentioned all medicines are mixed the back entry soaked 18 minutes, boil fried 35 minutes of the little fire of reuse then with big fire, filter medicinal liquid, make powder, be used for the treatment of the severe thrombotic disease, as coronary atherosclerotic heart disease.

Embodiment 4: 1 kilogram every part

A kind of medicine of promoting coronary circulation and embolism resistance is made raw materials of effective components and is comprised: 15 kilograms of Radix Angelicae Sinensis, 17 kilograms of Rhizoma Chuanxiongs, 8 kilograms of the Radix Paeoniae Albas, 6 kilograms of Pheretimas, 59 kilograms of the Radixs Astragali, 13 kilograms on Flos Carthami, 12 kilograms in Semen Persicae, 10 kilograms of Radix Paeoniae Rubra, 22 kilograms of Radix Ophiopogonis, 7 kilograms of Radix Ginsengs, 22 kilograms in the Radix Rehmanniae, 13 kilograms of Fructus Schisandrae Chinensis, above-mentioned all medicines are mixed the back entry soaked 16 minutes, boil fried 38 minutes of the little fire of reuse then with big fire, filter medicinal liquid, be used for the treatment of slight thrombotic disease, such as slight pulmonary infarction.

Claims

1. the medicine of a promoting coronary circulation and embolism resistance is characterized in that making raw materials of effective components and comprises:

Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Paeoniae Alba 5-10 part, Pheretima 5-8 part, Radix Astragali 55-65 part, Flos Carthami 10-15 part, Semen Persicae 10-15 part, Radix Paeoniae Rubra 10-12 part, Radix Ophiopogonis 15-25 part, Radix Ginseng 5-10 part, Radix Rehmanniae 20-25 part, Fructus Schisandrae Chinensis 10-20 part, Hirudo 10-15 part, Radix Salviae Miltiorrhizae 10-18 part, Zaocys 10-20 part, Squama Manis 12-15 part, Rhizoma Smilacis Glabrae 15-18 part, Radix Glycyrrhizae 8-10 part.