A kind of Chinese medicine composition for the treatment of hypertensive heart disease and preparation method thereof
Technical field
The invention discloses a kind of Chinese medicine composition, especially treat Chinese medicine composition of hypertensive heart disease and preparation method thereof.Belong to Chinese medicine field.
Background technology
Hypertensive heart disease is to raise because blood pressure is long-term left ventricle load is increased the weight of gradually, and left ventricle is because of the compensatory organic heart disease that plump and expansion forms gradually.Hypertensive heart disease generally appear at the hypertension onset several years to ten more than year after, can be divided into cardiac functional compensatory period and cardiac functional decompensatory period according to changes of cardiac function situation.In cardiac functional compensatory period, patient can be without obvious subjective symptoms, but in cardiac functional decompensatory period, engender the symptom of left heart failure, when beginning only tired, be satiated with food or speak when too much and feel cardiopalmus, asthma, cough, later symptom increases the weight of gradually, above-mentioned symptom is paroxysmal outbreak, show as nocturnal paroxysmal dyspnea sputum mixed with blood more, when serious, acute lung edema can occur.
Hypertension can be divided into constitutional and two kinds of Secondary cases, various hypertension reach the regular hour and degree increases the weight of left chamber load, and left ventricular hypertrophy, increase occur then, all can be described as hypertensive heart disease.
Hypertensive heart disease Early manifestation is not generally true to type, and patient can or only have slight discomfort as cardiopalmus, headache etc. without obvious subjective symptoms, and these symptoms are mainly hypertensive general symptoms, without particularity.With the progress of hypertensive disease, patient engenders in early days at left ventricle concentric hypertrophy and without the expansion stage, and hypertension, pulse are loud, apex beat strengthens, and second sound of aortic area is hyperfunction; Expand the stage in left ventricle, apex beat is shifted to left down, is and praises sample apex beat, and border of cardiac dullness expands to left down, and apex first heart sound strengthens, and second sound of aortic area is loud and sonorous metal and adjusts; The course of disease further develops, when left ventricle obviously expands, and while also there is atherosclerotic lesion in aortic valve, aortic valve the second area of auscultation audible and relaxing period ripples sample noise, audible and fourth heart sound and various arrhythmia are as atrial fibrillation, premature beat etc.
When hypertension, due to arteries hypertonia, hinder heart pump and go out blood, the long-term high load capacity work of heart has just occurred that myocardial hypertrophy and stiffness index increase, and finally causes the pulmonary vein that enters heart to be obstructed, and forms pulmonary venous pleonaemia.When myocardial hypertrophy, oxygen demand increases, and blood supply relative deficiency often causes heart failure outbreak.Hypertensive heart disease clinical manifestation in late period is:
1, because left ventricular diastolic function is abnormal, can cause pulmonary venous pleonaemia, main manifestations is: (1) occur the symptoms such as fatigue, asthma, cardiopalmus, cough, spitting of blood; (2) when flat sleeping, occur out of breathly, after sitting up, take a turn for the better; (3) activity is little, but occurs dyspnea, and when serious, patient can wake up with a start in one's sleep.
2, left heart failure often can involve right ventricular function decline, forms whole heart failure, and main manifestations is: (1) cyanosis; (2) jugular vein is obviously full; (3) right Upper abdominal pain, and have hepatomegaly; (4), when serious, can there is anasarca in edema of pair of lower extremities; (5) oliguria, comes across heart failure more and loses the compensatory phase; (6) often there is cerebrovascular disease in middle-aged and elderly people.
In the technology of existing field of Chinese medicines treatment hypertensive heart disease, Chinese invention patent application CN200910045755.2 discloses a kind of name on August 4th, 2010 and has been called " Ramulus Uncariae Cum Uncis extract and the purposes in preparation blood fat reducing and resisting cardiac hypertrophy medicine thereof ", its chief component thing is Ramulus Uncariae Cum Uncis, prescription is simply and only for reducing blood fat, cannot entirety nurse one's health health, effect is single.
Summary of the invention
For existing treatment present situation, one of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of hypertensive heart disease, there is no pain, easy to operate, evident in efficacy, the feature that has no side effect, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for hypertensive heart disease, preferred proportioning, takes off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 1-5 part, Radix Astragali 25-35 part, Stigma Croci 1-5 part, Poria 15-35 part, Radix Trichosanthis 15-30 part, Semen Platycladi 5-12 part, Lignum Dalbergiae Odoriferae 1-5 part, Radix Ophiopogonis 5-15 part, Radix Paeoniae Alba 25-35 part, Spica Prunellae 8-15 part, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.3-0.9 part, Ramulus Uncariae Cum Uncis 9-15 part.
Treat a Chinese medicine composition for hypertensive heart disease, preferred proportioning, takes off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 2-4 part, Radix Astragali 28-32 part, Stigma Croci 2-4 part, Poria 20-30 part, Radix Trichosanthis 20-25 part, Semen Platycladi 7-10 part, Lignum Dalbergiae Odoriferae 2-4 part, Radix Ophiopogonis 8-12 part, Radix Paeoniae Alba 28-32 part, Spica Prunellae 10-13 part, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.4-0.7 part, Ramulus Uncariae Cum Uncis 11-14 part.
Treat a Chinese medicine composition for hypertensive heart disease, best proportioning, takes off the primary raw material of stating weight proportion and is prepared from: 3 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 3 parts of Stigma Crocis, 25 parts, Poria, 22 parts of Radix Trichosanthis, 8 parts of Semen Platycladi, 3 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Radix Ophiopogonis, 30 parts of the Radix Paeoniae Albas, 11 parts of Spica Prunellaes, 0.6 part of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 12 parts of Ramulus Uncariae Cum Uncis.
A preparation method for the treatment of hypertensive heart disease Chinese medicine composition, preparation process is as follows:
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 10-30 minute, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, turn 20-40 minute at a simmer, leach medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 15-35 minute at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
The preparation method of above-mentioned Chinese medicine composition, 1. step is blended into cold water soak 10-30 minute (preferably 15-25 minute, is more preferably 20 minutes).
The preparation method of above-mentioned Chinese medicine composition, 1. step turns 20-40 at a simmer minute (preferably 25-35 minute, is more preferably 30 minutes).
The preparation method of above-mentioned Chinese medicine composition, 2. step turns 15-35 at a simmer minute (preferably 20-30 minute, is more preferably 25 minutes).
Using method: for making the present invention reach optimum therapeuticing effect, medicinal liquid is divided into two parts, in sooner or later taking half an hour after meal.
The pharmacological effect of each crude drug is respectively: 3 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 3 parts of Stigma Crocis, 25 parts, Poria, 22 parts of Radix Trichosanthis, 8 parts of Semen Platycladi, 3 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Radix Ophiopogonis, 30 parts of the Radix Paeoniae Albas, 11 parts of Spica Prunellaes, 0.6 part of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 12 parts of Ramulus Uncariae Cum Uncis.
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature.GUIXIN, lung, kidney channel.There is boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, for improving immunity of organisms, anticancer growth, the deficiency of vital energy is cloudy loses.
The Radix Astragali: sweet in the mouth, warm in nature.Have effect of invigorating QI to consolidate the body surface resistance, diuretic detumescent, weak for the deficiency of vital energy, blood deficiency and yellow complexion, is Qi-tonifying drug.
Stigma Croci: sweet in the mouth, property is flat.There is the intracellular oxygen metabolism function of enhancing, improve the hypoxia-bearing capability of heart, blood circulation promoting and blood stasis dispelling, effect of removing pathogenic heat from blood and toxic substance from the body, has certain protective role to heart, and has the anticancer effect of cancer that significantly presses down.
Poria: sweet in the mouth, light, property is flat.There is promoting diuresis to eliminate damp pathogen, effect of spleen invigorating mind calming, for edema oliguria, irritability, insufficiency of the spleen lack of appetite.
Radix Trichosanthis: sweet in the mouth, cold nature.Have promoting the circulation of QI the chest stuffiness relieving, effect of detumescence and apocenosis, has a pain for uncomfortable in chest, calentura excessive thirst.
Semen Platycladi: sweet in the mouth, property is flat.There is tranquilizing by nourishing the heart, hidroschesis, effect of intestine moistening, for fidgets due to deficiency insomnia, cardiopalmus severe palpitation.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature.There is promoting flow of QI and blood, pain relieving, effect of hemostasis, for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge.
Radix Ophiopogonis: sweet in the mouth, property cold syndrome of the stomach.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, On Antagonizing Experimental Arrhythmia, and effect of increase coronary flow, for vexed insomnia, Tianjin wound is thirsty.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating, dizzy for having a headache, hypochondriac pain, stomachache, blood deficiency and yellow complexion.
Spica Prunellae: acrid in the mouth, hardship, cold in nature.Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, dizzy for having a headache, hypertension.
Natural Broneolum Syntheticum (dextro Borneolum Syntheticum): acrid in the mouth, cool in nature.There is loose stagnated fire, reducing swelling and alleviating pain, effect of the refreshment of having one's ideas straightened out.
Ramulus Uncariae Cum Uncis: sweet in the mouth, cool in nature.There is heat clearing away suppressing the hyperactive liver, effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., dizzy for having a headache, hypertension, twitches.
Chinese medicine composition of the present invention meets the principle of Chinese traditional treatment hypertensive heart disease.The medical material of selecting has efficacy in lowering high blood pressure, and strongly fragrant depressed, the pain relieving of the heart of releiving, the arresting convulsion of calming the nerves, and hypertensive heart disease patient is had to fabulous therapeutical effect, is to treat at present the comparatively desirable medicine of hypertensive heart disease.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1
1 gram of Radix Panacis Quinquefolii, 25 grams of the Radixs Astragali, 1 gram of Stigma Croci, 15 grams, Poria, 15 grams of Radix Trichosanthis, 5 grams of Semen Platycladi, 1 gram of Lignum Dalbergiae Odoriferae, 5 grams of Radix Ophiopogonis, 25 grams of the Radix Paeoniae Albas, 8 grams of Spica Prunellaes, 0.3 gram of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 9 grams of Ramulus Uncariae Cum Uncis.
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 10 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 20 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 15 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
embodiment 2
2 grams of Radix Panacis Quinquefoliis, 28 grams of the Radixs Astragali, 2 grams of Stigma Crocis, 20 grams, Poria, 20 grams of Radix Trichosanthis, 7 grams of Semen Platycladi, 2 grams of Lignum Dalbergiae Odoriferaes, 8 grams of Radix Ophiopogonis, 28 grams of the Radix Paeoniae Albas, 10 grams of Spica Prunellaes, 0.4 gram of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 11 grams of Ramulus Uncariae Cum Uncis.
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 15 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 25 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 20 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
embodiment 3
4 grams of Radix Panacis Quinquefoliis, 32 grams of the Radixs Astragali, 4 grams of Stigma Crocis, 30 grams, Poria, 25 grams of Radix Trichosanthis, 10 grams of Semen Platycladi, 4 grams of Lignum Dalbergiae Odoriferaes, 12 grams of Radix Ophiopogonis, 32 grams of the Radix Paeoniae Albas, 13 grams of Spica Prunellaes, 0.7 gram of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 14 grams of Ramulus Uncariae Cum Uncis.
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 25 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 35 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 30 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
embodiment 4
5 grams of Radix Panacis Quinquefoliis, 35 grams of the Radixs Astragali, 5 grams of Stigma Crocis, 35 grams, Poria, 30 grams of Radix Trichosanthis, 12 grams of Semen Platycladi, 5 grams of Lignum Dalbergiae Odoriferaes, 15 grams of Radix Ophiopogonis, 35 grams of the Radix Paeoniae Albas, 15 grams of Spica Prunellaes, 0.9 gram of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 15 grams of Ramulus Uncariae Cum Uncis.
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 30 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 40 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 35 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
embodiment 5
3 grams of Radix Panacis Quinquefoliis, 30 grams of the Radixs Astragali, 3 grams of Stigma Crocis, 25 grams, Poria, 22 grams of Radix Trichosanthis, 8 grams of Semen Platycladi, 3 grams of Lignum Dalbergiae Odoriferaes, 10 grams of Radix Ophiopogonis, 30 grams of the Radix Paeoniae Albas, 11 grams of Spica Prunellaes, 0.6 gram of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 12 grams of Ramulus Uncariae Cum Uncis.
1. by Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis is placed in non iron container, be blended into cold water soak 20 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 30 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 25 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Using method: for making the present invention reach optimum therapeuticing effect, medicinal liquid is divided into two parts, in sooner or later taking half an hour after meal.
model case one
Cao XX, female, 58 years old, Qingdao of Shandong province Laoshan District.Symptom: patient suffers from hypertension 8 years, occurs in the recent period the symptoms such as asthma, cough, dyspnea, is hypertensive heart disease through hospital diagnosis, and with slight heart failure phenomenon.Sick age: 1 year.Examine the time: on January 27th, 2011; Use Chinese medicine composition of the present invention, every day twice, in sooner or later taking half an hour after meal, use 3 days, dyspnea symptom is alleviated; Use 15 days, asthma, cough symptom disappear completely; Use 20 days, breathe and recover normal, symptoms of heart failure disappears, and recovers.
model case two
zou XX, man, 42 years old, Linzi District, Zibo City, Shandong Province.Symptom: start to occur spitting of blood before patient's first quarter moon, cardio palmus shape, occurs symptom out of breath when flat crouching, and after sitting up, symptom takes a turn for the better to some extent, understands through hospital, and patient suffers from hypertension, and diagnosing it is hypertensive heart disease.Sick age: 1 month.Examine the time: on April 15th, 2011; Use Chinese medicine composition of the present invention, every day twice, in sooner or later taking half an hour after meal, use the same day, cardiopalmus symptom alleviates; Use 3 days, spitting of blood number of times reduces, and cardiopalmus disappears, and flat sleeping seasonal epidemic pathogens emergency case shape takes a turn for the better to some extent; Use 10 days, spitting of blood transference cure, flat sleeping seasonal epidemic pathogens emergency case shape has also disappeared; Consolidate 10 days, malaise symptoms does not occur again, between the operating period, has no side effect.
model case three
bag XX, man, 35 years old, Hanting District, Weifang City of Shandong Province., there is dyspneic symptom in symptom: patient suffers from hypertension all the year round, for several times oneself is suppressed in bed awakely before 2 months, be hypertensive heart disease through hospital diagnosis.Sick age: 2 months.Examine the time: on July 22nd, 2011; Use Chinese medicine composition of the present invention, every day twice, in sooner or later taking half an hour after meal, use 2 days, obviously sensation breathing is smooth and easy, there is no sensation uncomfortable in chest; Use 15 days, only occur 2 times during this time dyspnea symptom night; Continue to use 10 days, breathe smooth and easyly, do not occur again breathing the phenomenon of suffering night; Consolidate 10 days, so far, dyspnea symptom does not occur again in drug withdrawal.
In order to verify the effect of compound Chinese medicinal preparation of the present invention, we have carried out on a large scale, the drug study (embodiment 5) of many person-times.Specific experiment result is as following table:
Use traditional Chinese medicine composition for treating hypertensive heart disease of the present invention, effect is remarkable, prove that through clinical trial effective percentage is 95%, cure rate is 70%, compared with the medicine of simple blood pressure lowering, effective percentage is high by 25%, and cure rate is high by 40%, and do not need to take again other and treat cardiopathic medicine and carry out auxiliary treatment, alleviated patient body and burden economically; Compared with treating cardiopathic medicine with nitroglycerin class, effective percentage is high by 10%, cure rate is high by 45%, and the symptom not only can alleviate heart attack time, can also thoroughly treat heart disease and regulate blood pressure, therefore, Chinese medicine composition of the present invention is the medicine that a kind of curative effect is comprehensively treated hypertensive heart disease.