CN102114110B - Granules with function of obesity treatment and preparation method thereof - Google Patents

Granules with function of obesity treatment and preparation method thereof Download PDF

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CN102114110B
CN102114110B CN201010618939.6A CN201010618939A CN102114110B CN 102114110 B CN102114110 B CN 102114110B CN 201010618939 A CN201010618939 A CN 201010618939A CN 102114110 B CN102114110 B CN 102114110B
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王钢柱
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Abstract

The invention relates to granules for treating obesity and a preparation method thereof. The granules are prepared by the method comprising the following steps of: weighing finger citron, dogwood, 5 to 7 parts of lucid ganoderma, lotus leaf, cassia seed and ginkgo leaf according to weight parts; mixing the component raw materials; decocting twice by adding water, wherein water in an amount which is 10 times the weight of the raw materials is added for the first time for decocting for 2 hours, and water in an amount which is 8 times the weight of the raw materials is added for the second time for decocting for 1.5 hours; filtering decoction extract obtained by the two operations by using a sieve with the meshes of between 160 and 180 respectively; concentrating filtrate until the density is 1.23 to 1.26g/cm<3> to obtain extract; and mixing the extract and dextrin in a weight part ratio of 1:(2.5-3.5) for granulation to obtain the granules. The granules can regulate blood fat, ensure that people are clear-minded, relaxed and refreshed, and improve the quality of life.

Description

A kind of granule with treatment function of obesity and preparation method thereof
Technical field
The present invention relates to a kind of granule and preparation method thereof, particularly relate to a kind of fat granule and preparation method thereof for the treatment of.
Background technology
Obesity (obestity) is a kind of chronic disease, occupy World Health Organization (WHO) estimate it be the mankind face at present the most out in the cold, a kind disease but sickness rate sharply rises.
Simple Obesity is that in all obesity, proportion is the highest, reaching 95% left and right, is just the obesity that non-disease causes in brief, and this class systemic Fat Distribution is more even, there is no endocrine confusion phenomena, without its family of dysbolismus disease, often have fat medical history yet.
Fat affect labour force, easily suffer wound: the people of obesity increases because of body weight, and the heavy burden of each organ of health all increases, and can cause lumbago, arthralgia, dyspepsia, asthma; Often To Be Protected from Heat for the people of body obesity, hyperhidrosis, skin wrinkle place dermatitis, scratch easily occur, and easily merge suppurative or fungal infection; Because of handicapped, also easily suffer various wounds, fracture and sprain etc.Obesity is the natural enemy of health of people longevity: scientist studies and finds that overweight people's complicated with brain thromboembolism is higher 1 times than regular severe one with the sickness rate of heart failure, suffers from coronary heart disease, hypertension, diabetes, doubly, due to the invasion and attack of these diseases, people's life-span will obviously shorten the high 3-5 of cholelithiasis person calibration ordinary person.Obese people easily suffers from endocrine and metabolic disease: because obesity causes internal metabolism and cryptorrhea, often can cause that multiple metabolic disease is as diabetes, hyperlipemia, hyperuricemia etc., female irregular menstruation etc.Fat all right combined with obstructive sleep apnea hypopnea syndrome, phlebothrombosis, the danger that increases anesthesia and perform the operation.The fat sickness rate that can also increase malignant tumor, obese women carcinoma of endometrium than the high 2-3 of normal women doubly.The incidence rate calibration ordinary person of obese males colon and rectum carcinoma and carcinoma of prostate is high.
Summary of the invention
The object of this invention is to provide and a kind ofly can regulate blood fat, make human body clearheaded, health is light, refreshed, the granule with treatment function of obesity of improving the quality of living.
Another object of the present invention is to provide a kind of preparation method with the granule for the treatment of function of obesity.
The present invention adopts following technical scheme:
A kind of granule with treatment function of obesity, it is characterized in that adopting following method to make: the first step: take by weight: 25~30 parts of Fructus Citri Sarcodactylis, 10~13 parts of Fructus Corni, 5~7 parts of Ganodermas, 20~25 parts of 30~39 parts, Folium Nelumbinis and Semen Cassiaes, 5~7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.23~1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 160-200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23~1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
A kind of preparation method with the granule for the treatment of function of obesity, it is characterized in that it is comprised of following steps: the first step: take by weight: 25~30 parts of Fructus Citri Sarcodactylis, 10~13 parts of Fructus Corni, 5~7 parts of Ganodermas, 20~25 parts of 30~39 parts, Folium Nelumbinis and Semen Cassiaes, 5~7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.23~1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 160-200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23~1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
The invention has the beneficial effects as follows: patient can by granule of the present invention according to every day 6~12g amount directly take after mixing it with water, be a kind of green health solid beverage that is applicable to obese people.
Granules in Treating obesity of the present invention has following features:
1, safety: product of the present invention is selected not only edible but also natural plants that can be medicinal, has no side effect, environmental protection.
2, convenient: use product of the present invention, patient is easy to use, and therapeutic effect is good.
3, evident in efficacy: to use product of the present invention, can make hyperlipidemia obese patient blood fat reduce, alleviate abdominal obesity, the symptom of alleviation physical fatigue etc.
In granules medicine formula of the present invention, the effect of each crude drug is:
Fructus Citri Sarcodactylis: pungent, hardship, sweet, temperature, nontoxic, enter liver, spleen, stomach three warps, there are the multiple medicinal functions such as activating QI to eliminate phlegm, cough-relieving relieving distension, the liver soothing and the spleen invigorating stomach function regulating.< < book on Chinese herbal medicine newer > > is called it and can be controlled gas soothing liver-QI.The catharsis function of liver is whole body QI movement being in harmonious way normally, QI and blood and tune, and meridians tonneau, the functional activity of internal organs organ maintains normally, and the defeated cloth metabolism side of the operation of blood, body fluid and cereal nutrient is able to normally.If liver imbalance is smooth, whether mechanism of qi disorder this liters or not, the cereal nutrients such as blood glucose can not be with the gas of clear sun defeated cloth all over the body and stagnant in blood, there is hyperglycemia.Or do not fall and fall, let out under precise and tiny, there is glucose in urine.Further cause the defeated cloth of other cereal nutrients such as fat, protein disorderly, cause many complication.
In side, take Fructus Citri Sarcodactylis as monarch drug, and depressed liver-energy dispersing and QI regulating, complies with liver bar soothing the liver.
Fructus Corni: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, interior-heat is quenched one's thirst.Modern pharmacology research shows, Fructus Corni has antiinflammatory, antibacterial, the effects such as anti-stress, antioxidation, blood fat reducing.
Ganoderma: cure mainly asthenia, insomnia, cough, asthma, dyspepsia, malignant tumor etc.Modern pharmacology research shows, Ganoderma has antitumor, protecting liver and detoxication, the anti-ageing effect of waiting for a long time.
Folium Nelumbinis: delicate fragrance rises loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, the effect of dissipating blood stasis hemostasis.Modern pharmacology research shows, Folium Nelumbinis has effect for reducing blood fat.
In side, take Fructus Corni, Ganoderma, Folium Nelumbinis is ministerial drug, supplementing QI and nourishing YIN, auxiliary monarch drug performance curative effect.
Semen Cassiae: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.Modern pharmacology research shows, Semen Cassiae has antibacterial, blood fat reducing, blood pressure lowering, the effects such as anti-platelet aggregation.
Folium Ginkgo: astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough due to deficiency of the lung, modern pharmacology research shows, Folium Ginkgo is to coronary heart disease, angina pectoris, hyperlipidemia, the intrinsic certain effect of anticoagulant.
In side, take Semen Cassiae, Folium Ginkgo is adjuvant, and all medicines in mediation side, correct each medicine property of medicine.
Adopt the present invention to treat fat clinical treatment standard as follows:
Use granule of the present invention every day 1-2 time, each 6-10g, 8 weeks is a course for the treatment of;
Effective standard is: use 1 course for the treatment of of granule of the present invention, fundamental symptoms (subcutaneous fat minimizing >=1.5cm) obviously improves, and triglyceride, cholesterol, the overall improvement of three indexs of high density lipoprotein surpass 70%.
Effectively standard is: uses 1 course for the treatment of of granule of the present invention, and fundamental symptoms (subcutaneous fat reduces by 0.5-1.5cm) change substantially, triglyceride, cholesterol, three indexs of high density lipoprotein are totally improved between 30%-70%.
Invalid standard is: use 1 course for the treatment of of granule of the present invention, fundamental symptoms (subcutaneous fat minimizing≤0.5cm) is not improved, and triglyceride, cholesterol, three indexs of high density lipoprotein are totally improved less than 30%.
Patient's 268 examples that are put to the test, are diagnosed as obesity through hospital above county level, and without severe cardiac Liver and kidney complication, at 27~70 years old age, the edible food that adds unguentum of the present invention of experimental group, takes 56 days continuously, and effective case 108 people of test-meal group, account for 40.3% of test-meal group sum; Effectively case 100 people, account for 37.3% of test-meal group sum; Ineffective Cases 60 people, account for 22.4% of test-meal group sum.
Model case:
Lee * *, female, 45 years old, fat history 4 years, triglyceride 2.0 mmol/L while entering to organize, cholesterol 8.0 mmol/L, high density lipoprotein 0.6 mmol/L, use granule of the present invention after 8 weeks, subcutaneous fat reduces 1.6cm, triglyceride 1.6 mmol/L, cholesterol 5 mmol/L, HDL1 .3 mmol/L, blood lipids index is obviously improved.
Hole * *, man, 55 years old, fat history 3 years, triglyceride 2.3 mmol/L while entering to organize, cholesterol 7.0 mmol/L, high density lipoprotein 0.3 mmol/L, use granule of the present invention after 8 weeks, subcutaneous fat reduces 2.0cm, triglyceride 1.7 mmol/L, cholesterol 4 mmol/L, HDL1 .7 mmol/L, blood lipids index is obviously improved.
Literary composition * *, female, 48 years old, fat history 4 years, triglyceride 3.3 mmol/L while entering to organize, cholesterol 8.5 mmol/L, high density lipoprotein 0.4 mmol/L, use granule of the present invention after 8 weeks, subcutaneous fat reduces 1.8cm, triglyceride 0.9 mmol/L, cholesterol 6 mmol/L, HDL1 .6 mmol/L, blood lipids index is obviously improved.
* *, man, 35 years old, fat history 2 years, triglyceride 2.5 mmol/L while entering to organize, cholesterol 6.5 mmol/L, high density lipoprotein 0.3mmol/L, use granule of the present invention after 8 weeks, subcutaneous fat reduces 1.7cm, triglyceride 1.3mmol/L, cholesterol 4.5 mmol/L, HDL1 .8 mmol/L, blood lipids index is obviously improved.
The specific embodiment
Content of the present invention is, a kind of preparation method that is used for the treatment of fat granule, and it adopts following ratio of weight and number component:
Embodiment 1
A granule with treatment function of obesity, it is characterized in that adopting following method to make: the first step: take by weight: 25 parts of Fructus Citri Sarcodactylis, 10 parts of Fructus Corni, 7 parts of Ganodermas, 25 parts of 30 parts, Folium Nelumbinis and Semen Cassiaes, 6 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and filter with 180 mesh sieves respectively, it is 1.23g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.25g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
A preparation method with the granule for the treatment of function of obesity, is characterized in that it is comprised of following steps: the first step: take by weight: 25 parts of Fructus Citri Sarcodactylis, 10 parts of Fructus Corni, 7 parts of Ganodermas, 25 parts of 30 parts, Folium Nelumbinis and Semen Cassiaes, 6 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and filter with 180 mesh sieves respectively, it is 1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
Embodiment 2
A granule with treatment function of obesity, it is characterized in that adopting following method to make: the first step: take by weight: 30 parts of Fructus Citri Sarcodactylis, 12 parts of Fructus Corni, 7 parts of Ganodermas, 20 parts of 36 parts, Folium Nelumbinis and Semen Cassiaes, 7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and filter with 160 mesh sieves respectively, it is 1.23g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
A preparation method with the granule for the treatment of function of obesity, is characterized in that it is comprised of following steps: the first step: take by weight: 30 parts of Fructus Citri Sarcodactylis, 12 parts of Fructus Corni, 7 parts of Ganodermas, 20 parts of 36 parts, Folium Nelumbinis and Semen Cassiaes, 7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and filter with 180 mesh sieves respectively, it is 1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
Embodiment 3
A granule with treatment function of obesity, it is characterized in that adopting following method to make: the first step: take by weight: 25 parts of Fructus Citri Sarcodactylis, 10 parts of Fructus Corni, 5 parts of Ganodermas, 25 parts of 39 parts, Folium Nelumbinis and Semen Cassiaes, 5 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 160-200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:3 according to ratio of weight and number described extractum and dextrin obtains described granule.
A preparation method with the granule for the treatment of function of obesity, is characterized in that it is comprised of following steps: the first step: take by weight: 25 parts of Fructus Citri Sarcodactylis, 10 parts of Fructus Corni, 5 parts of Ganodermas, 25 parts of 39 parts, Folium Nelumbinis and Semen Cassiaes, 5 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.23g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.

Claims (2)

1. one kind has the granule for the treatment of function of obesity, it is characterized in that adopting following method to make: the first step: take by weight: 25~30 parts of Fructus Citri Sarcodactylis, 10~13 parts of Fructus Corni, 5~7 parts of Ganodermas, 20~25 parts of 30~39 parts, Folium Nelumbinis and Semen Cassiaes, 5~7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.23~1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 160-200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23~1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
2. the preparation method of granule with treatment function of obesity, it is characterized in that it is comprised of following steps: the first step: take by weight: 25~30 parts of Fructus Citri Sarcodactylis, 10~13 parts of Fructus Corni, 5~7 parts of Ganodermas, 20~25 parts of 30~39 parts, Folium Nelumbinis and Semen Cassiaes, 5~7 parts of Folium Ginkgos; Second step: said components raw material is mixed, decoct with water twice, add for the first time the water of 10 times of weight, decoct 2 hours, add for the second time the water of 8 times of weight, decoct 1.5 hours, decoct extracting solution twice and with 160-180 mesh sieves, filter respectively, it is 1.23~1.26g/cm that filtrate is concentrated into density 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule;
Or said components raw material is mixed, add 70% alcohol reflux twice, add for the first time 8 times of amounts of 70% ethanol, extract and reflux 2 hours; Add for the second time 6 times of amounts of 70% ethanol, extract and reflux 1.5 hours, extracted twice liquid filters with 160-200 mesh sieves respectively, and filtrate recycling ethanol, is concentrated into density 1.23~1.26g/cm 3, obtaining extractum, the ratio mixing granulation that is 1:2.5~3.5 according to ratio of weight and number described extractum and dextrin obtains described granule.
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