CN103861075B - Chinese medicine being used for the treatment of insomnia and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine being used for the treatment of insomnia and preparation method thereof, wherein, Chinese medicine comprises following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri.The invention has the beneficial effects as follows: the theory of Chinese medical science that Chinese medicine of the present invention utilizes China traditional, based on purging liver-fire, tranquilizing mind, treatment of insomnia patients has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Description

Chinese medicine being used for the treatment of insomnia and preparation method thereof

Technical field

The present invention relates to the medicine coming from plant, animal or raw mineral materials, particularly a kind of Chinese medicine being used for the treatment of insomnia and preparation method thereof.

Background technology

Insomnia is due to feelings will, diet internal injury, and after being ill and old, innate deficiency, the causes of disease such as timidness due to deficiency of the heart, cause lack of preservation of spirit or irritability, thus cause often obtaining the class disease that ortho sleep is feature.Main manifestations is the length of one's sleep, the degree of depth is not enough and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy then be insomnia all night.

Insomnia is one of common clinical card, though do not belong to critical illness, normal hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.

Insomnia is called " unable to close the eyes ", " insomnia ", " must not crouch " in "Nei Jing", and thinks that insomnia reason mainly contains two kinds, and one is the impact of other diseases, as cough, vomiting, abdominal distention etc., makes people must not peacefully sleeping; Two is that negative and positive of qi and blood is become estranged, make people not able person sleep, as " Plain Questions condition of disease opinion " is said: " people has sleeping and uneasy to some extent person, He Ye ... dirtyly injure to some extent, and essence is posted to some extent, then pacify, and old friend can not hang its disease also." " Plain Questions inverse adjust opinion " also record " disorder of the stomach leading to insomnia with restlessness " and refer to " sun bright inverse must not from Qi Dao " " inverse gas must not crouch, and coarse breathing with wheeze person ", later age, doctor extended to all incoordination between the spleen and stomach, disturbed in phlegm-damp, dyspepsia, so that the uneasy person that gets into bed of sleeping all belongs to this.This name of disease that Difficult Classic proposes the earliest " being insomnia ", " difficult difficult through 46 " thinks that the pathogenesis that old man is insomnia is " vim and vigour decline, muscle not cunning, and the road of Rong Wei is puckery, therefore day can not be smart, and night must not sleep also ".The reason of having a sleepless night is caused to have multiple, 1, feelings will hinders or unsuccessful by feelings will, depression of liver-QI, pathogenic fire derived from stagnation of liver-QI, the pathogenic fire disturbance mind, irritability and being insomnia.Or by overaction of the five emotions, flaming of heart-fire in the interior, mind disturbance and being insomnia.Or by pondering over too, damage heart spleen, painstaking effort secretly consume, mental derangement, the weary source of insufficiency of the spleen biochemistry, and deficiency of nutrient QI and blood, can not support the mind, and namely " Lei Zheng Zhi Cai is insomnia " is said: " worry impairing spleen, spleen anemia is damaged, and is insomnia year in year out." 2, eating and drinking without temperance taste are impaired, dyspepsia is stagnated, stop up hold back in, gastric qi is become estranged, and yang-energy is floating more in outer and sleeping uneasiness of sleeping, as " Zhang Shi doctor must not lead to crouch " cloud: " slippery and rapid pulse effectively must not the person of crouching, in have dyspepsia phlegm-fire, this be disorder of the stomach leading to insomnia with restlessness also." or by surfeit delicious food savoury, make raw expectorant heat, the disturbance mind and sleeplessness.Or by eating and drinking without temperance, taste are injured, dysfunction of the spleen in transportation, insufficiency of generating and transforming QI and blood, deficiency of heart-blood, the heart is become homeless and is supported and have a sleepless night.3, after being ill, old prolonged illness blood deficiency, puerperal loses blood, old insufficiency of blood etc., causes deficiency of heart-blood, and the heart is become homeless foster, irritability and being insomnia.Said as " Jing Yue's complete work is insomnia ": " naivete and the person of being insomnia, must ying-qi deficiency also, seek main blood, blood deficiency is then difficult to nourish heart, then mental derangement of having a guilty conscience." 4, innate deficiency, timidness due to deficiency of the heart ferritic excess of YIN, hold concurrently because of excess of sexual intercourse, kidney yin consumption wound, can not on give in the heart, discordance between water(the kidney)and fire(the heart), heart-fire is solely high; Or the hepatic and renal YIN deficiency, liver-yang is partially high, and it is dynamic that god contained by fire, failure of the heart and kindey to integrate and mind is not peaceful.As said in " Jing Yue's complete work is insomnia ": " Kidney-Yin asthenia of essence and blood, negative and positive are not handed over, and god has ear of being discontented with one's home." also have because of timidness due to deficiency of the heart, being terrified suddenly, the state of mind is uneasy, so that lies awake all night or sleep but not soundly, as said in " miscellaneous diseases source and course rhinoceros candle be insomnia drowsirness source and course ": " have heart and gallbladder to fear timid, tactile thing is easily shied, and how ominous dream is, the fidgets due to deficiency person of being insomnia.”

Have a sleepless night not enough with the length of one's sleep, Depth of sleep not and can not allaying tiredness, to regain one's strength with energy be main syndromes feature.Wherein the length of one's sleep, deficiency person can show as difficulty falling asleep, and sleep night and easily wake up, be difficult to sleep after waking up, severe patient is insomnia even all night again.Depth of sleep inadequate person sleeps when waking up when often showing as night, sleep then disintoxicated, or dream of sleeping night is many.Inadequate due to the length of one's sleep and degree of depth quality, causing after waking up can not allaying tiredness, shows as dizziness, headache, spiritlessness and weakness, cardiopalmus, forgetful, even malaise etc.

In modern medicine, insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS (DlMS), for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia often brings painful and psychological burden greatly to patient, can damage other every aspects of health again because of abuse insomnia drug.Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.Some old men have to carry out hypnosis by stable class due to serious insomnia, have just become " good friend " in the course of time with stable.This phenomenon is very general in friend person in middle and old age, and think that stable clothes a little has no relations more, in fact, life-time service can form dependence, even addiction.Go down with the increase at age because old people's hepatic and renal function weakens, sleeping pill of helping yourself can cause liver and kidney failure, produces drug resistance, causes mental disorder, bring out Other diseases.Sleeping pill to be through liver, renal metabolism in vivo mostly, long-term taking can increase the burden of Liver and kidney, have also can cause liver enlargement, hepatalgia, jaundice, edema, albuminuria, hematuria and feel sick, abdominal distention, inappetence, the hepatic and renal function injure such as constipation and the intestines and stomach reaction.Some sleeping pill also can cause lassitude, the hypophrenia, the accumulate poisoning symptoms such as blood pressure drops, even cause respiratory and circulatory function obstacle situation.Therefore, old people applies stable class medicine more care should be used to.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of processing technology easy, toxic and side effects is little, with low cost, based on Chinese medicine being used for the treatment of insomnia of purging liver-fire, tranquilizing mind and preparation method thereof.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine being used for the treatment of insomnia, described Chinese medicine comprises following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri.

In described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 19 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 21 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 19 weight portion, Radix Ophiopogonis 23 weight portion, Concha Margaritifera 23 weight portion, Radix Saposhnikoviae 20 weight portion, Radix Ginseng 19 weight portion, Ganoderma 26 weight portion, Rhizoma Dioscoreae 19 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 21 weight portion, Herba Lysimachiae foenum-graeci 23 weight portion, Cortex Cinnamomi 22 weight portion, Roast Rhizoma Zingiberis Recens 24 weight portion, Semen Ziziphi Spinosae 21 weight portion, Radix Bupleuri 12 weight portion, Radix Rehmanniae Preparata 23 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 17 weight portion, Radix Rubiae Yunnanensis 17 weight portion and Herba Leonuri 18 weight portion.

In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the Chinese medicine of insomnia, the dosage form of described Chinese medicine is decoction, and described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, adds water to dipped medical material upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, and filter, obtain filtrate a, medicinal residues are for subsequent use;

Step 3: again added water by the medicinal residues in step 2, crosses medicinal residues upper surface 2-3cm to water logging, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine of insomnia, the dosage form of described Chinese medicine is granule, and described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, adding relative to the determining alcohol of 4 ~ 8 times, mixture after mix homogeneously is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, dry under the condition of 40 ~ 50 DEG C, obtains granule.

Described Chinese medicine preferably also comprises: Radix Polygalae, Rhizoma Acori Graminei, Semen Aesculi, Cortex Albiziae and Radix Glycyrrhizae.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion, Herba Leonuri 12-24 weight portion, Radix Polygalae 10-20 weight portion, Rhizoma Acori Graminei 8-24 weight portion, Semen Aesculi 10-20 weight portion, Cortex Albiziae 15-25 weight portion and Radix Glycyrrhizae 15-30 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 18 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 18 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 17 weight portion, Radix Ophiopogonis 22 weight portion, Concha Margaritifera 19 weight portion, Radix Saposhnikoviae 21 weight portion, Radix Ginseng 18 weight portion, Ganoderma 32 weight portion, Rhizoma Dioscoreae 22 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 23 weight portion, Herba Lysimachiae foenum-graeci 18 weight portion, Cortex Cinnamomi 17 weight portion, Roast Rhizoma Zingiberis Recens 19 weight portion, Semen Ziziphi Spinosae 12 weight portion, Radix Bupleuri 17 weight portion, Radix Rehmanniae Preparata 24 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 18 weight portion, Radix Rubiae Yunnanensis 18 weight portion, Herba Leonuri 18 weight portion, Radix Polygalae 14 weight portion, Rhizoma Acori Graminei 16 weight portion, Semen Aesculi 15 weight portion, Cortex Albiziae 21 weight portion and Radix Glycyrrhizae 21 weight portion.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the theory of Chinese medical science that Chinese medicine of the present invention utilizes China traditional, based on purging liver-fire, tranquilizing mind, treatment of insomnia patients has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Detailed description of the invention

The invention provides a kind of Chinese medicine being used for the treatment of insomnia, comprise following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri; Preferably, also comprise: Radix Polygalae, Rhizoma Acori Graminei, Semen Aesculi, Cortex Albiziae and Radix Glycyrrhizae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Fluoritum: sweet, temperature.GUIXIN, lung, kidney channel.Function cures mainly: tranquilizing mind, warming the lung, warm palace.For insomnia and dreamful sleep, palpitation and being susceptible to fright, cough and asthma due to lung deficiency, infertility.

Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Radix Notoginseng: warm in nature, sweet in the mouth, micro-hardship, nontoxic, return liver, stomach warp.Function: hemostasis; Loose blood; Analgesic therapy.Cure mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea; Puerperal, stasis of blood the moon was suffered from abdominal pain; Sore, carbuncle and painful swelling.Health care cures mainly: blood vessel dilating, reduce blood pressure, and improves microcirculation, increases blood flow, prevention and therapy heart and brain tissues ischemia, anoxia; Promote the synthesis of protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA), building body; Promote blood cell metabolism, balance adjustment blood cell; Two-ways regulation nervus centralis, improves mental, strengthens learning and memory ability; Enhancing human body immunity function, antitumor; Hemostasis, blood circulation promoting and blood stasis dispelling; Protect the liver, antiinflammatory; Slow down aging; Two-ways regulation blood glucose, reduction blood fat, cholesterol, suppression arteriosclerosis.In addition, Radix Notoginseng has anti-liver injury effect, PNS(arasaponin) significantly can reduce CCl4 hepatic injury mice serum ALT activity.Methanolic extract, to CCl4, D mono-Liver Damage in Rats of causing of galactosamine, significantly can reduce AST and lactic acid dehydrogenase (LDH) in rat blood serum active, hepatocellular degeneration necrosis is alleviated.Radix Notoginseng also has effect of anti hepatic fibrosis, and to the hepatic injury of N-nitrosodimethylamine poisoning rat, with Radix Notoginseng powder treatment 4 weeks, hepatocellular degeneration necrosis is alleviated, between hepatocyte, collagen fiber reduce.To the poisoning hepatic fibrosis rats of CCl4, while giving CCl4 moulding, oral Radix Notoginseng powder carries out control 9 weeks, can alleviate hepatic steatosis, inflammatory cell infiltration, hepatocellular degeneration necrosis.Be reduced to the hypertrophy of fibrocyte and collagen.Radix Notoginseng has certain choleretic effect, and Radix Notoginseng injection has the Rabbit Liver internal congestion jaundice that a-α-naphthyl isothiocyanate causes and significantly reduces serum bilirubin, promotes bile secretion effect.Radix Notoginseng promotes hepatic protein synthesis, increases 3H-TdR and mixes speed to damaged liver DNA, increases 3H-leucine and mixes speed to hepatic protein.

Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, returns liver, the heart, spleen channel, hematonic, emmenagogue, analgesic, effect of invigorating blood circulation of enriching blood, cures mainly all cards of blood deficiency, ulcer sores.For oral administration: to decoct soup, 6-12 gram; Or enter ball, loose; Or infusing drugs in wine; Or deposited cream.1. first Wang Haogu is write Materia Medica of Decoction: Radix Angelicae Sinensis, few the moon of starting with, with the main blood of its heart also; Enter foot lunar, wrap up in blood also with its spleen; Enter sufficient the moon of fainting, with its blood stored in the liver also.Head can removing blood stasis, and body can nourish blood, the promoting the circulation of blood of tail energy, user regardless of, not as not making.If use entirely, all can enrich blood at ginseng, stilbene; Leading a cow, Radix Et Rhizoma Rhei, all can removing blood stasis, assistant makes fixed point, and user is when know.From osmanthus, attached, the Fructus Evodiae is then hot; Then tremble with fear from Radix Et Rhizoma Rhei, Natrii Sulfas.Only wine Radix Angelicae Sinensis (steamed), controls headache again, with its all headache all belong to wood, therefore with blood medicine master it.2. bright Ni Zhumo writes " book on Chinese herbal medicine converge with speech ": all sick nights notably, disorders of blood also, should with it, all sick cold caused by deficiency persons, YANG unable to attach to somewhere also, should use it.Pyrexial malaria cold and heat, not at the outer intramuscular of skin, and wash in skin, see among husband's skin, the institute of ying-qi can also, and pyrexial malaria is prolonged for a long time, empty in ying-qi, and cold and heat are handed over and striven, and sweating is washed, with blood health preserving with drugs battalion, then battalion and and with defend tune, how seek and defend and adjust, can not the stopping of pyrexial malaria.3. Sheng Nong's herbal classic ": sweet in the mouth, temperature.Main cough with dyspnea, pyrexial malaria, cold and heat, wash in skin (" grand sight this " washes sound tinea), and married woman is leaked down sterilization, all evil wound infectionss, gold wound.Boil drink.

Hoopoe: function cures mainly: softening liver for calming endogenous wind, tranquilizing mind.

Radix Ophiopogonis: sweet; Micro-hardship; Cold.Cure mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, and asthenia dysphoria with smothery sensation, quenches one's thirst, and calentura Tianjin is hindered, dry mouth and throat, constipation." book on Chinese herbal medicine converges and says ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung also.Main deficiency of heart-QI, palpitation with fear palpitation with a distress feeling, dimly forgetful, spirit fall; Or the lung-heat dryness of the lung, cough sound running fire, consumptive lung disease leaf scorch, dyspnea due to deficiency of losing heart, in fire volt lung, spitting of blood hemoptysis; Or asthenia exopathogenic heat, body fluid is dry few; Or taste are dry dries up, constipation due to insufficiency dyschezia; This card that all cardiopulmonary kidney spleen unit asthenic fire is strongly fragrant also.But sweet in the mouth gas is put down, energy lung benefiting gold, bitter in the mouth is cold in nature, can fall heart-fire, and body profit matter is mended, and can support medulla renis, and the merit specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, and weakness and emaciation such as to be losed heart at the disease, then belong to strain bright." book on Chinese herbal medicine newly organized ": Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, and reducing the asthenic fever, separates the dryness of the lung, fixed cough, and what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often few use and can not be successfully unfortunate also.Do not know that Radix Ophiopogonis must be multiplex, strength begins large, and Gai Huofu is in lung, and sparkle liquid in doing, more than Radix Ophiopogonis, then fire can not be made; Heat is vehement in stomach, and endure its moon to the greatest extent, more than Radix Ophiopogonis, then fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to bladder heat also, do not imitate with the medicine of water flowing, do not imitate with the agent of pathogenic fire reducing, this again what with? the gas of lid bladder, must the respectful clearly order row of the part of the body cavity above the diaphragm housing the heart and lungs, and fire is decline, and water is lower logical.The respectful clearly order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, and heat of the lung, then making that lung is respectful is clearly not all right, and bladder fire closes, and water also closes.Therefore for logical bladder person, must the gas of lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpful, if eventually not Radix Ophiopogonis clear in have benefit, the fire of bladder can be rushed down, and don't damage the gas of bladder, but few with it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and the beginning has Ji also.

Concha Margaritifera: salty, cold.Return liver, heart channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.For headache due to common cold, rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, headache as wrapped up in, heavy sensation of the body acroesthesia person, be equal to Rhizoma Et Radix Notopterygii, Rhizoma Ligustici and use; Control rubella pruritus, polygamy 5 Radix Sophorae Flavescentis, Herba Schizonepetae, Radix Angelicae Sinensis etc.

Radix Ginseng: sweet, micro-hardship is flat.Return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.

Rhizoma Dioscoreae: sweet in the mouth, property are flat, enter lung, spleen, kidney channel; Not dry oiliness, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica summary five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, reduce phlegm saliva, profit skin ".Rhizoma Dioscoreae cook congee or with crystal sugar simmer ripe after take, poor to health, colitis, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treat weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, and sweet in the mouth matter is moistened, that can treat that lung suffers from a deficiency of the kidney and damage quenches one's thirst, passes out semen, is with inferior disease.Be described as angle's medicine.

Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, display Fructus Jujubae has same immunosuppressant with azathioprine; The generation of antibody can be suppressed to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and other effects of inhibitory action are not produced to non-reacted antibody: the two glucoside A of the flavone in Fructus Jujubae, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has the effect increasing cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mice can be extended.Nearest report Fructus Jujubae has the proliferation function of anticancer.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, micro-hardship, slightly warm in nature.Return spleen, kidney, heart channel.Modern medicine research proves that the action character of Radix Et Caulis Acanthopanacis Senticosi is substantially identical with Radix Ginseng, has and regulates body disorderly, make it to be tending towards normal function.Have good antifatigue effect, comparatively Radix Ginseng is remarkable, and significantly can improve hypoxia-bearing capability.The function such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Clothes of a specified duration " are made light of one's life by commiting suicide and are endured hardships ".Radix Et Caulis Acanthopanacis Senticosi contains noticeable composition---and eleutheroside, it can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi demonstrates its antifatigue effect, strengthens endurance and ability, increases alert and resourceful and learning capacity.Numerous usage obtains confirmation all in human experimentation.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, chronic disease cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.It has support immune system to have the report of considerable quantity to point out equally at present, recovers improper hypotension, improves blood circulation, makes disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.Radix Et Caulis Acanthopanacis Senticosi extract display can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore Radix Et Caulis Acanthopanacis Senticosi is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mice S180, K562 cell, and Radix Et Caulis Acanthopanacis Senticosi extract is containing multiple glycoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, leukocyte increasing, raising body to anoxia, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.There is obvious inhibitory action to tumor, also can promote that marrow hemopoietic stem cells makes leukocyte increase to grain-differentiate monocytes simultaneously.

Herba Lysimachiae foenum-graeci: sweet, light is flat.Function cures mainly: heat clearing away, circulation of qi promoting, and ascarid is driven in pain relieving.For headache due to common cold, toothache, laryngopharynx swelling and pain, fullness in the chest abdominal distention, ascariasis.

Cortex Cinnamomi: pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.

Roast Rhizoma Zingiberis Recens: pungent, temperature.Function cures mainly: with middle preventing or arresting vomiting.Be applicable to the disease such as incoordination between the spleen and stomach, nausea and vomiting.

Semen Ziziphi Spinosae: sweet, sour is flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.

Radix Bupleuri: clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improve skin delayed hypersensitivity reaction.Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1ml/ subcutaneous injection significantly can reduce the rat blood serum GPT that carbon tetrachloride causes for continuous 5 days and raise, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content are also close to normal.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.To enrich blood yin nourishing, life essence-filling, marrow-benefitting." Bencao Congxin ": " sharp blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus for kidney nourishing water, packing bone marrow.Again can tonifying spleen-yin, only chronic diarrhea.Control impairment caused by overstrain migratory arthralgia, cloudy losing is generated heat, dry cough phlegmatic cough, dyspnea with shortness of breath, and emptiness of the stomach feels hungry, and pox demonstrate,proves no pus of having a guilty conscience, and shin stock is ached after being ill, and the anxious pain of umbilicus abdomen in puerperal, feel card the moon and lose, lossless constipation, all kinds of dynamic blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments are strengthening renal yin to inhibit predominant yang medicine.”

Radix seu Caulis Verntilaginis Leiocarpae: sweet, temperature.Function cures mainly: benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.

Semen Brassicae Rapae: pungent is flat.Enter liver, spleen two warp.Function cures mainly: improving eyesight, heat clearing away, dampness removing.Control optic atrohic blindness, order is dark, jaundice, dysentery, dysuria.

Radix Rubiae Yunnanensis: bitter, sweet, temperature.Function cures mainly: regulating menstruation and activating blood, promoting tissue regeneration by removing blood stasis.For menoxenia, dysmenorrhea, blood deficiency amenorrhea, lumbago due to renal deficiency.

Herba Leonuri: enter the heart, liver, urinary bladder channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Treatment edema, dysuria.The treatment water stasis of blood is tied mutually, congestion obstacle bladder.Sore and toxic can be treated, urticaria.Promoting blood flow to regulate menstruation, for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, the stagnant stomachache of prolonged lochia, the stasis of blood.Can be used for traumatic injury again.Effect to uterus: Herba Leonuri decoct, ethanol extract and the leonurine isolated uterine to the many animals such as rabbit, cat has excitation.To cardiovascular effect: Herba Leonuri is to isolated guinea pig heart, myocardial infarction and ischemia model is caused with isoproterenol, significantly can increase coronary flow and decreased heart rate quite significantly. quiet note motherwort formulation makes anesthetized dog obviously increase coronary flow, reduce coronary resistance, the effect of decreased heart rate and minimizing output and left ventricular work.Antiplatelet aggregation and antithrombus formation: in vitro tests proves, intact animal's platelet aggregation that Herba Leonuri and extract thereof have antagonism ADP to induce. in vivo test also proves that Herba Leonuri significantly can reduce platelet and aggregation thereof in total number of blood platelet in peripheral circulation and alveolar wall blood capillary. and Herba Leonuri has remarkable dissolution to rabbit pulmonary circulation red thrombus. and in addition, Herba Leonuri also has the effects such as the cellular immunization of enhancing body.Other effect: Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine volume significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1:13-1:10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.

Radix Polygalae:

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Function cures mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.

Semen Aesculi: sweet, temperature.Return liver, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia.

Cortex Albiziae: sweet, flat.GUIXIN, liver, lung meridian.Function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.

Radix Glycyrrhizae: sweet in the mouth, property is put down, nontoxic, enters spleen, stomach, lung meridian." pearl sac " is recorded: raw sweet, flat; Process sweet, temperature.Function cures mainly: treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, and clothes are made light of one's life by commiting suicide and prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Emergency is detoxified, and is in harmonious proportion hundred medicines." herbal classic " records it: main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, and incised wound swells, removing toxic substances.Medication is avoided: wet Sheng distension, edema person should not use.Can not with Cyprinus carpio with eating, with eating, meeting is poisoning.The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum.Take the Radix Glycyrrhizae of larger dose for a long time, can edema etc. be caused.Collective Notes to the Canon of Materia medica is recorded: " art, Resina Toxicodendri, Radix Sophorae Flavescentis make for it.Dislike Radix Polygalae.The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum four thing ".

In described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 19 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 21 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 19 weight portion, Radix Ophiopogonis 23 weight portion, Concha Margaritifera 23 weight portion, Radix Saposhnikoviae 20 weight portion, Radix Ginseng 19 weight portion, Ganoderma 26 weight portion, Rhizoma Dioscoreae 19 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 21 weight portion, Herba Lysimachiae foenum-graeci 23 weight portion, Cortex Cinnamomi 22 weight portion, Roast Rhizoma Zingiberis Recens 24 weight portion, Semen Ziziphi Spinosae 21 weight portion, Radix Bupleuri 12 weight portion, Radix Rehmanniae Preparata 23 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 17 weight portion, Radix Rubiae Yunnanensis 17 weight portion and Herba Leonuri 18 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion, Herba Leonuri 12-24 weight portion, Radix Polygalae 10-20 weight portion, Rhizoma Acori Graminei 8-24 weight portion, Semen Aesculi 10-20 weight portion, Cortex Albiziae 15-25 weight portion and Radix Glycyrrhizae 15-30 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 18 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 18 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 17 weight portion, Radix Ophiopogonis 22 weight portion, Concha Margaritifera 19 weight portion, Radix Saposhnikoviae 21 weight portion, Radix Ginseng 18 weight portion, Ganoderma 32 weight portion, Rhizoma Dioscoreae 22 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 23 weight portion, Herba Lysimachiae foenum-graeci 18 weight portion, Cortex Cinnamomi 17 weight portion, Roast Rhizoma Zingiberis Recens 19 weight portion, Semen Ziziphi Spinosae 12 weight portion, Radix Bupleuri 17 weight portion, Radix Rehmanniae Preparata 24 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 18 weight portion, Radix Rubiae Yunnanensis 18 weight portion, Herba Leonuri 18 weight portion, Radix Polygalae 14 weight portion, Rhizoma Acori Graminei 16 weight portion, Semen Aesculi 15 weight portion, Cortex Albiziae 21 weight portion and Radix Glycyrrhizae 21 weight portion.

When the dosage form of Chinese medicine is decoction, described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, adds water to dipped medical material upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, and filter, obtain filtrate a, medicinal residues are for subsequent use;

Step 3: again added water by the medicinal residues in step 2, crosses medicinal residues upper surface 2-3cm to water logging, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

When the dosage form of Chinese medicine is granule, described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, adding relative to the determining alcohol of 4 ~ 8 times, mixture after mix homogeneously is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, dry under the condition of 40 ~ 50 DEG C, obtains granule.

Embodiment 1 decoction

Embodiments provide a kind of Chinese medicine being used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 20 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Radix Notoginseng 27 weight portion, Radix Angelicae Sinensis 28 weight portion, hoopoe 15 weight portion, Radix Ophiopogonis 18 weight portion, Concha Margaritifera 19 weight portion, Radix Saposhnikoviae 18 weight portion, Radix Ginseng 24 weight portion, Ganoderma 31 weight portion, Rhizoma Dioscoreae 23 weight portion, Fructus Jujubae 25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17 weight portion, Herba Lysimachiae foenum-graeci 29 weight portion, Cortex Cinnamomi 27 weight portion, Roast Rhizoma Zingiberis Recens 29 weight portion, Semen Ziziphi Spinosae 19 weight portion, Radix Bupleuri 10 weight portion, Radix Rehmanniae Preparata 18 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 27 weight portion, Semen Brassicae Rapae 15 weight portion, Radix Rubiae Yunnanensis 13 weight portion and Herba Leonuri 16 weight portion.

Its preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, adds water to dipped medical material upper surface 3cm, soaks 5 hours;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 200ml, and filter, obtain filtrate a, medicinal residues are for subsequent use;

Step 3: again added water by the medicinal residues in step 2, crosses medicinal residues upper surface 2cm to water logging, soaks 4 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Embodiment 2 granule

Embodiments provide a kind of Chinese medicine being used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 19 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 21 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 19 weight portion, Radix Ophiopogonis 23 weight portion, Concha Margaritifera 23 weight portion, Radix Saposhnikoviae 20 weight portion, Radix Ginseng 19 weight portion, Ganoderma 26 weight portion, Rhizoma Dioscoreae 19 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 21 weight portion, Herba Lysimachiae foenum-graeci 23 weight portion, Cortex Cinnamomi 22 weight portion, Roast Rhizoma Zingiberis Recens 24 weight portion, Semen Ziziphi Spinosae 21 weight portion, Radix Bupleuri 12 weight portion, Radix Rehmanniae Preparata 23 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 17 weight portion, Radix Rubiae Yunnanensis 17 weight portion and Herba Leonuri 18 weight portion.

Its preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, adding relative to the determining alcohol of 6 times, mixture after mix homogeneously is the ethanol of 85%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.25, spraying dry, the inlet temperature 160 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes granule, dry under the condition of 40 DEG C, obtains granule.

Embodiment 3 granule

Embodiments provide a kind of Chinese medicine being used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 18 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 18 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 17 weight portion, Radix Ophiopogonis 22 weight portion, Concha Margaritifera 19 weight portion, Radix Saposhnikoviae 21 weight portion, Radix Ginseng 18 weight portion, Ganoderma 32 weight portion, Rhizoma Dioscoreae 22 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 23 weight portion, Herba Lysimachiae foenum-graeci 18 weight portion, Cortex Cinnamomi 17 weight portion, Roast Rhizoma Zingiberis Recens 19 weight portion, Semen Ziziphi Spinosae 12 weight portion, Radix Bupleuri 17 weight portion, Radix Rehmanniae Preparata 24 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 18 weight portion, Radix Rubiae Yunnanensis 18 weight portion, Herba Leonuri 18 weight portion, Radix Polygalae 14 weight portion, Rhizoma Acori Graminei 16 weight portion, Semen Aesculi 15 weight portion, Cortex Albiziae 21 weight portion and Radix Glycyrrhizae 21 weight portion.

Its preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, adding relative to the determining alcohol of 7 times, mixture after mix homogeneously is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.08, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 82 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, dry under the condition of 45 DEG C, obtains granule.

Toxicity test

1, acute toxicity test: granule prepared by the granule prepared with the embodiment of the present invention 2 and embodiment 2 is for experimental subject, granule is dissolved in distilled water respectively, give 4 groups of white mice feeding dispensings respectively with 140 of clinical consumption per day times, 200 times, 160 times and 220 times, observe 7; The all white mice of result are strong deposits, and its diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

2, long term toxicity test: by the embodiment of the present invention 2 granule, be dissolved in water to mice by 7.81,18.34 and 40.11g crude drug/kg, continuous uses 12 weeks are distinguished to two groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to two groups of test mices all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is very little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.The granule prepared with embodiment 3 according to above-mentioned test method is for experimental subject, and experimental result illustrates that granule prepared by the embodiment of the present invention 3 is little to toxicity after mice long-term prescription equally, does not also have difference reaction, application safety after drug withdrawal.

3, toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; By decoction prepared by embodiments of the invention 1, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Clinical trial

Case selection: fetch the 200 routine insomniacs coming from the court's patients in neurological department, man 95 example, female 105 example, age 35-65 year, medical history 2 months-8 years.200 routine patients are divided into four groups at random, often organize 50 examples, be respectively embodiment group 1-3 and matched group.

Diagnostic criteria: difficulty falling asleep, is difficult to maintenance and sleeps, and at least occurs 3 times weekly and continues more than 1 month, causes the obvious worries of patient or have impact on daily life, there is not the makings type factor causing above-mentioned condition by sleep.

Therapeutic Method:

Embodiment group 1: the decoction taking the embodiment of the present invention 1, dose drinks one day, and every day drinks at twice, sooner or later respectively once; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Embodiment group 2: the granule taking the embodiment of the present invention 2, after meal 1 time every night, each 6g; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Embodiment group 3: the granule taking the embodiment of the present invention 2, after meal 1 time every night, each 6g; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Matched group: take chlormezanone sheet, takes before sleeping, an a slice; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

The standard of curative effect evaluation:

Recovery from illness: transference cure, recover normal the length of one's sleep or Nighttime sleep more than 6 hours, sleep deep, hale and hearty after waking up;

Effective: remission, increase by more than 3 hours the length of one's sleep, Depth of sleep increases;

Effective: symptom is improved, and increases the length of one's sleep less than 3 hours;

Invalid: symptom is as front, and after treatment, insomnia is not improved or instead increases the weight of.

Therapeutic outcome

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs of the present invention to have a sleepless night, show for Western medicine on therapeutic effect, there is significant progress; As can be seen from Table 2, adopt treatment by Chinese herbs of the present invention to have a sleepless night, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 3 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Effective	Effectively	Invalid	Cure and obvious effective rate	Total effective rate
								Embodiment group 1	50	22	20	8	0	（42）84.0%	100%
Embodiment group 2	50	22	21	7	0	（43）86.0%	100%
								Embodiment group 3	50	25	22	3	0	（47）94.0%	100%
Matched group	50	11	17	14	8	（28）56.0%	84.0%

Table 2 respectively group is cured after treating 3 courses for the treatment of respectively and effective number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Embodiment group 1	42	12(28.6%)	19(45.2%)	11(26.2%)
Embodiment group 2	43	14(32.6%)	19(44.2%)	10(23.2%)
					Embodiment group 3	47	16(34.0%)	25(53.2%)	6(12.8%)
Matched group	28	0(0%)	11(39.3%)	17(60.7%)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Cure and effective follow-up of patients's half a year in each embodiment group 1-4 and matched group, result is added up simultaneously, and embodiment group 1 is cured and in 42 effective examples, 22 examples of healing are without recurrence, and 3 example recurrences in effective 20 routine patients, without any untoward reaction; Embodiment group 2 is cured and in 43 effective examples, 22 examples of healing are without recurrence, and 1 example recurrence in effective 21 routine patients, without any untoward reaction; Embodiment 3 cure and effective 47 examples all without recurring, without any untoward reaction; Matched group is cured and in effective 28 examples, 11 routine patients 5 example recurrences of healing, effective 17 routine patients 9 example recurrences, and over the course for the treatment of, finds that the untoward reaction that daytime is tired, dizzy or have a headache appears in some patient.

Model case: Liu, female, 57 years old, Symptoms was: difficulty falling asleep, was difficult to maintain sleep, at least occurred 4 times weekly, and continue about 1 year, the obvious mental status of patient is bad, and energy is not concentrated, and has had a strong impact on daily life.Use the medicine of the embodiment of the present invention 2 to treat, after meal 1 time every night, each 6g 7 days is a course for the treatment of, uses 3 recoveries from illness courses for the treatment of continuously, follows up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. be used for the treatment of the Chinese medicine of insomnia, it is characterized in that, described Chinese medicine is made up of the raw medicinal material of following parts by weight: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

2. the Chinese medicine being used for the treatment of insomnia according to claim 1, it is characterized in that, described Chinese medicine is made up of the raw medicinal material of following parts by weight: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

3. the Chinese medicine being used for the treatment of insomnia according to claim 1, it is characterized in that, described Chinese medicine is made up of the raw medicinal material of following parts by weight: Fluoritum 19 weight portion, Radix Salviae Miltiorrhizae 23 weight portion, Radix Notoginseng 21 weight portion, Radix Angelicae Sinensis 21 weight portion, hoopoe 19 weight portion, Radix Ophiopogonis 23 weight portion, Concha Margaritifera 23 weight portion, Radix Saposhnikoviae 20 weight portion, Radix Ginseng 19 weight portion, Ganoderma 26 weight portion, Rhizoma Dioscoreae 19 weight portion, Fructus Jujubae 21 weight portion, Radix Et Caulis Acanthopanacis Senticosi 21 weight portion, Herba Lysimachiae foenum-graeci 23 weight portion, Cortex Cinnamomi 22 weight portion, Roast Rhizoma Zingiberis Recens 24 weight portion, Semen Ziziphi Spinosae 21 weight portion, Radix Bupleuri 12 weight portion, Radix Rehmanniae Preparata 23 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portion, Semen Brassicae Rapae 17 weight portion, Radix Rubiae Yunnanensis 17 weight portion and Herba Leonuri 18 weight portion.

4. the preparation method being used for the treatment of the Chinese medicine of insomnia according to any one of claim 1-3, is characterized in that, the dosage form of described Chinese medicine is decoction, and described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, adds water to dipped medical material upper surface 2-5cm, soaks 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, and filter, obtain filtrate a, medicinal residues are for subsequent use;

Step 3: again added water by the medicinal residues in step 2, crosses medicinal residues upper surface 2-3cm to water logging, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

5. the preparation method being used for the treatment of the Chinese medicine of insomnia according to any one of claim 1-3, is characterized in that, the dosage form of described Chinese medicine is granule, and described preparation method comprises the following steps:

Step one: take all raw medicinal materials according to parts by weight, adding relative to the determining alcohol of 4 ~ 8 times, mixture after mix homogeneously is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, dry under the condition of 40 ~ 50 DEG C, obtains granule.