CN104771614A

CN104771614A - Drug for treating neurasthenia having symptoms of deficiency in heart and gallbladder and preparation method thereof

Info

Publication number: CN104771614A
Application number: CN201510118475.5A
Authority: CN
Inventors: 孙祖真
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-18
Filing date: 2015-03-18
Publication date: 2015-07-15

Abstract

The invention discloses a drug for treating neurasthenia having symptoms of deficiency in heart and gallbladder and a preparation method thereof. The drug is composed of the following traditional Chinese herbals: polygala root, acorus tatarinowii, crude dragon bone, uncooked oyster, sea clam shell, coptis, cape jasmine, lophatherum gracile, tabasheer, akebia stem, spine date seed, albizia bark, cockscomb, aspongopus, chicken's gizzard membrane, semen oroxyli, rhizoma gastrodiae, sorghum root, amber, cypress fruit, pine among the Tuckahoe, and red rhodobryum. The drug has the functions of boosting qi, relieving convulsion, tranquilizing, stabilizing the mind, purging the fire in heart, soothing the liver, regulating the collaterals, nourishing the kidney, and consolidating the basis, is mainly used to treat neurasthenia having symptoms of deficiency in heart and gallbladder, and has the advantages of simple preparation technology, little side and toxic effect, user-friendliness, easy manufacture, low cost, and direct action on lesions.

Description

One treats neurasthenic medicine of type of deficiency of heart-QI and gallbladder-QI and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly one treats neurasthenic medicine of type of deficiency of heart-QI and gallbladder-QI and preparation method thereof.

Background technology

Neurasthenia is with worried, the weak neurosis for main manifestations, caused by not nervous system pathology changes.Neurasthenia is because cerebral nerve activity is in tension for a long time, and one group that causes brain excitement and inhibit feature to lack of proper care and produce easily excited with spirit, and mental fatiguability, the symptoms such as emotional instability are function of nervous system's sexual disorders of feature.

An easy crowd: neurasthenia (Neurasthenia) refers to spirit easily excited and mental easy fatigue, often with a kind of neurosis of emotion worry with some psychology physiological symptoms.Neurasthenia one word is proposed by American physician (Beard 1868) at first, cancels this noun again in recent years at a point apoplexy due to endogenous wind.This diagnosis of neurasthenia is all retained in China and International Classification of Diseases.At present, the neurasthenic symptom of handlebar is confined to the easily tired tendency for main manifestations in the world.Between twenty and fifty phase morbidity is more, and mental worker is more common.Account for the more than half of outpatient clinic Patients with Neurosis.Neurasthenia is that a class is easily excited and mental easily tired with spirit, neurosis disorder that is worried and mental symptoms of being often in a bad mood.Neurasthenia is due to nervous and stress for a long time, makes brain ergasia reduced capability, protracted inflammation, time heavy time light, the state of an illness fluctuates.The personality feature of patient is: timid, feels oneself inferior, responsive, suspicious, and dependency is strong, self-doubt, wilful, and irritable, possessiveness is poor.Socio-psychological factors is neurasthenic Etiological.As work and study, over-burden, the spiritual hypertonicity continued, and examination stress is large, and learning target exceedes practical capacity, interpersonal difficulty, dog-eat-dog, and death of relative and life baffle.Socio-psychological factors can noly cause a disease, and depends on the time of the character of stimulation, intensity and effect, also relevant with personal character.Neurasthenia is that a class is easily excited and mental easily tired with spirit, neurosis disorder that is worried and mental symptoms of being often in a bad mood.

The cause of disease: 1. type of higher nervous activity belongs to weak type and osculant people, easily suffers from neurasthenia.This kind of individuality often shows as, unsociable and eccentric, timid, responsive, suspicious, irritable or when anything crops up easily nervous.2. nervous function hypertonicity, long-term psychical conflict and psychic trauma cause negative affect to experience, and live irregular, and undue fatigue can not get fully rest etc. can become primary disease cause.China, at beginning of the sixties late 1950s, once carried out a large amount of investigation to the neurasthenic cause of disease, thought that nervous function hypertonicity was the one of the main reasons of primary disease.Patient more than half reflects work or study, mainly mental activity, hypertonicity.Not only mental activity overlong time, task is overweight; Study or operational difficulties.Especially strict especially to require, attention needs the intellectual work of high concentration, more easily causes hypertonicity and fatigue.3. infect, poisoning, malnutrition, endocrine disturbance, craniocerebral trauma and physical disease etc. also can become this pathogenetic inducement.4. it is the another kind of more common reason of primary disease that the negative affect that long-term psychical conflict and psychic trauma cause is experienced.Study and work is not suitable with, family quarrel, and marriage, Love Affairs are dealt with improperly, and interpersonal difficulty, mostly cause contradiction and intrapsychic conflict inwardly patient, becomes long-term painful root.And for example relatives' sudden death, the great misfortune of family, negative affects such as living and suffer setbacks, also can inspire sorrow, be painful is experienced, and causes neurasthenic generation.5. life is busy unordered, the destruction of work and rest rule and sleep habit, and lacks sufficient rest, and making anxiety and fatigue can not get recovering, is also neurasthenic easy factor.

Pathology: neurasthenia mainly a variety of causes causes the reduction of cerebral cortex process of intercentral inhibition.Because process of intercentral inhibition is in the development of human race and individual evening process of excitation occurring and occurs, because of but more fragile, higher nervous activity hypertonicity even lack of proper care or with other harmful factors time (as; Body other diseases), it not only easily suffers damage, and usually suffers damage at first, shows as the relatively hyperfunction i.e. neurasthenic commitment of process of excitation.Now, the ability of self control of patient lowers, and some can control the emotion that should not betray at ordinary times and emotional responses can out of controlly show, as; Irritability, instability.Irritability release adds the consumption of neurocyte energy, and, make the excitement of higher nervous activity--suppress rule disorderly.In addition, due to weakening of process of intercentral inhibition, make again neurocyte recovery capability lower, cause the minimizing of neurocyte energy and debilitating to increase.So, patient Yi Xingfen clinically, exhaustion also just fast.

Classical symptom: one, neurasthenic symptom Signs: 1. easy excited, irritability.2. mental easily tired, as reading study is slightly of a specified duration, then feel feeling of fullness in the head, giddy; Absent minded.3. headache, position are not fixed.4. sleep disorder, mostly is difficulty falling asleep, early awakening, or not easily falls asleep after waking up again, many nightmares.5. autonomic nervous dysfunction, can tachycardia, perspiration, anorexia, constipation, diarrhoea, menoxenia, premature ejaculation.6. Secondary cases hypochondriacal idea.Two, patient's neurasthenia complicated clinical manifestation, there are multiple mental symptom and somatization simultaneously, be summed up and can be divided into six large class symptoms: the sensitivity of the internal external stimulus of (1) mental deficiency, tired mind (2), the symptom of comprehensive many patients, can summarize jittery feature: 1. do not have organic disease; 2. patient more notes certain position, certain symptom, painful more obvious, if shift its attention, then obviously alleviates and even eliminates; 3. the distribution of afflicted area not necessarily meets the region of anatomy, and position is not also fixed, and maybe can change; 4. the symptom that describes of patient is many and assorted, people is missed the main points, says most of the day, finally also to do to be ignorant of where uncomfortable he is.(3) anxious state of mind, easily tired irritability, shortage patience.Often show as: 1. easily 2. tired many melancholys easily like susceptible to get angry.(4) tonicity pain.(5) insomnia, dreaminess.(6) psychophysiological disorders.

The traditional Chinese medical science: neurasthenia belongs to the category of being insomnia with melancholia in Chinese medicine, because sleep disorder is principal contradiction, therefore controls mainly with opinion of being insomnia.As " the large puzzled opinion of Ling Shu Miraculous Pivot or Divine Axis " institute's cloud: " defend gas and must not enter the moon, often stay in sun.Stay in sun that then yang-energy is full, yang-energy completely then sun lifts up Sheng; The moon then cloudy deficiency of vital energy must not be entered, therefore the unable to close the eyes." " Ling Shu Miraculous Pivot or Divine Axis evil an objective section " point out: " the present gas visitor that faints hides six mansions in five, then defend gas and walk alone in outward, row, in sun, must not enter the moon.Row is in sun then yang-energy Sheng, and yang-energy Sheng Zeyang lifts up sunken, must not enter the moon, the deficiency of YIN, therefore not close the eyes." visible, it is neurasthenic key point that negative and positive are become estranged.Chinese traditional treatment neurasthenia, the history of existing several thousand, from Huangdi's Internal Classics to Compendium of Material Medica, all has related drugs and formula to record.Chinese medicine achieves significant achievement in control neurasthenia, and recent cure rate increases, and application clinically, also at development, shows the prospect that it is good, has larger potential estimating compared with western medical treatment.Dialectically to be divided into: the 1. flourishing symptom of heart-fire: dysphoria and insomnia, restlessness is peaceful, dry mouth and tougue, oliguria with reddish urine, aphtha of the mouth and tongue, red tip of the tongue, yellow and thin fur, and rapid pulse is strong or count accurately.2. pathogenic fire derived from stagnation of liver-QI symptom: being irritable and getting angry easily, dreaminess of being insomnia, even lies awake all night, and with dizzy feeling of fullness in the head, conjunctival congestion tinnitus, xerostomia and bitter, anorexia, constipation is urinated red, red tongue with yellow fur, stringy and rapid pulse.3. symptom is disturbed in expectorant heat: dysphoria and insomnia uncomfortable in chest, nausea, belch, with heaviness of the head with dazzle, bitter taste, red tongue with yellowish and greasy fur, slippery and rapid pulse.4. hyperactivity of fire caused by deficiency of YIN symptom: palpitation and restlessness, dysphoria and insomnia, soreness of waist foot is soft, and companion is dizzy, and tinnitus is forgetful, seminal emission, dry mouth and lack of saliva, dysphoria with feverish sensation in the chest palms and soles, the few tongue of red tongue, thready pulse and counting.5. deficiency of both the heart and spleen symptom: dreaming often and waking easily, palpitation and amnesia, mental fatigue with loss of appetite, has a dizzy spell, with extremity asthenia, lustreless complexion, pale tongue with thin fur, thready pulse without strength.Be found in wound or puerperal severe loss of blood person.6. the heart and gallbladder deficiency of vital energy

Symptom: dysphoria and insomnia, dreaming often and waking easily, timidity and palpitation, tactile thing is easily shied, with spontaneous perspiration of breathing hard, fatigue and weakness, light red tongue, stringy pulse.

Doctor trained in Western medicine common drug is treated: neurasthenic Drug therapy: (1) anxiolytic drugs: conventional Benzodiazepines, can select: diazepam (stabilizing) 2.5 ~ 5.0mg, chlordiazepoxide (chlordiazepoxide) 10 ~ 20mg, estazolam (estazolam) 1 ~ 2mg, hydroxyzine (atarax) 25 ~ 50mg, alprazolam 0.4 ~ 0.8mg, lorazepam (tavor) 1 ~ 2mg etc., 3 times/d, serve on 1 ~ 2 week.Patient can be helped to improve anxiety, anxiety and sleep disorder.(2) sedative hypnotic drug: the obvious person of sleep disorder, can select: triazolam 0.25 ~ 0.5mg, nitrazepam 5 ~ 10mg, estazolam 1 ~ 2mg, or clonazepam 2 ~ 4mg, takes, serve on 1 ~ 2 week before sleeping every night.In order to avoid producing drug dependence, this kind of medicine is oversize for unsuitable service time; Or several drugs replaces or is interrupted use.(3) beta-blocker: sympathetic hyperfunction, as anxiety, cardiopalmus, tremble, the obvious person of symptom such as hyperhidrosis, Propranolol (propranolol) 10 ~ 20mg can be tried out, 3 times/d, can certain effect be had.(4) tricyclic drugs: the mixing of anxiety and depression emotion exists, and the person that has early awakening, can select doxepin (doxepin) or amitriptyline, 25 ~ 50mg, take, 1 time/d before sleeping; To alleviate anxiety and depression emotion, extend the length of one's sleep.The less second filial generation antidepressants of multiselect side effect, as SSRI class medicine, are advisable with low dosage.

Take this type of Western medicine throughout the year and have additive and dependency, stop using and can occur giving up and rebound phenomenon, long-term taking toxic side effect.Compared with Western medicine, Chinese medicine has very large advantage.

Summary of the invention

Technical problem to be solved by this invention is, provide one and treat the neurasthenic medicine of type of deficiency of heart-QI and gallbladder-QI, relieving convulsion with QI invigorating, tranquilizing the mind is Therapeutic Principle, hold concurrently with clear eliminating heart-fire, soothing the liver and network, nourishing kidney Rong Mu, hold up soil to consolidate, cure mainly neurasthenia, processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost, focus of going directly, has no side effect.

For solving the problems of the technologies described above, the invention provides one and treat the neurasthenic medicine of type of deficiency of heart-QI and gallbladder-QI, wherein, described medicine comprises following raw medicinal material: Radix Polygalae, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Concha Meretricis seu Cyclinae, Rhizoma Coptidis, Fructus Gardeniae, Herba Lophatheri, Concretio Silicea Bambusae, Caulis Akebiae, Semen Ziziphi Spinosae, Cortex Albiziae, Flos Celosiae Cristatae, Aspongopus, Endothelium Corneum Gigeriae Galli, Semen Oroxyli, Rhizoma Gastrodiae, Radix Sorghum vulgare Pers., succinum, Strobilus Cupressi, Lignum Poria, Rhodobryum roseum Limpr..

Wherein, the weight portion Soviet Union of described raw medicinal material is than being: Radix Polygalae 35-45 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Os Draconis 10-14 weight portion, Concha Ostreae 12-23 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Rhizoma Coptidis 25-30 weight portion, Fructus Gardeniae 20-25 weight portion, Herba Lophatheri 10-20 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Caulis Akebiae 3-7 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Cortex Albiziae 25-30 weight portion, Flos Celosiae Cristatae 10-20 weight portion, Aspongopus 15-25 weight portion, Endothelium Corneum Gigeriae Galli 12-21 weight portion, Semen Oroxyli 5-10 weight portion, Rhizoma Gastrodiae 20-24 weight portion, Radix Sorghum vulgare Pers. 15-23 weight portion, succinum 6-13 weight portion, Strobilus Cupressi 10-20 weight portion, Lignum Poria 4-7 weight portion, Rhodobryum roseum Limpr. 10-20 weight portion.

Wherein, also comprise Sanguis Gallus domesticus, Gecko, Moschus moschiferous is fragrant, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 35-45 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Os Draconis 10-14 weight portion, Concha Ostreae 12-23 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Rhizoma Coptidis 25-30 weight portion, Fructus Gardeniae 20-25 weight portion, Herba Lophatheri 10-20 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Caulis Akebiae 3-7 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Cortex Albiziae 25-30 weight portion, Flos Celosiae Cristatae 10-20 weight portion, Aspongopus 15-25 weight portion, Endothelium Corneum Gigeriae Galli 12-21 weight portion, Semen Oroxyli 5-10 weight portion, Rhizoma Gastrodiae 20-24 weight portion, Radix Sorghum vulgare Pers. 15-23 weight portion, succinum 6-13 weight portion, Strobilus Cupressi 10-20 weight portion, Lignum Poria 4-7 weight portion, Rhodobryum roseum Limpr. 10-20 weight portion, Sanguis Gallus domesticus 6-13 weight portion, Gecko 4-8 weight portion, Moschus 10-14 weight portion.

Wherein, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 45 weight portion, Rhizoma Acori Graminei 20 weight portion, Os Draconis 14 weight portion, Concha Ostreae 23 weight portion, Concha Meretricis seu Cyclinae 15 weight portion, Rhizoma Coptidis 30 weight portion, Fructus Gardeniae 25 weight portion, Herba Lophatheri 20 weight portion, Concretio Silicea Bambusae 25 weight portion, Caulis Akebiae 3 weight portion, Semen Ziziphi Spinosae 20 weight portion, Cortex Albiziae 30 weight portion, Flos Celosiae Cristatae 20 weight portion, Aspongopus 25 weight portion, Endothelium Corneum Gigeriae Galli 12 weight portion, Semen Oroxyli 5 weight portion, Rhizoma Gastrodiae 20 weight portion, Radix Sorghum vulgare Pers. 23 weight portion, succinum 6 weight portion, Strobilus Cupressi 10 weight portion, Lignum Poria 4 weight portion, Rhodobryum roseum Limpr. 10 weight portion.

Wherein, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 45 weight portion, Rhizoma Acori Graminei 20 weight portion, Os Draconis 14 weight portion, Concha Ostreae 23 weight portion, Concha Meretricis seu Cyclinae 15 weight portion, Rhizoma Coptidis 30 weight portion, Fructus Gardeniae 25 weight portion, Herba Lophatheri 20 weight portion, Concretio Silicea Bambusae 25 weight portion, Caulis Akebiae 3 weight portion, Semen Ziziphi Spinosae 20 weight portion, Cortex Albiziae 30 weight portion, Flos Celosiae Cristatae 20 weight portion, Aspongopus 25 weight portion, Endothelium Corneum Gigeriae Galli 12 weight portion, Semen Oroxyli 5 weight portion, Rhizoma Gastrodiae 20 weight portion, Radix Sorghum vulgare Pers. 23 weight portion, succinum 6 weight portion, Strobilus Cupressi 10 weight portion, Lignum Poria 4 weight portion, Rhodobryum roseum Limpr. 10 weight portion, Sanguis Gallus domesticus 6 weight portion, Gecko 4 weight portion, Moschus 10 weight portion.

In order to solve the problems of the technologies described above, present invention also offers the preparation method of described medicine, wherein, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 80 ~ 90%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.01 ~ 0.2 times, 0.01 ~ 0.12 times of lactose, the starch of 0.05 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.01 times of magnesium stearate, granulate, tabletting, makes.

Wherein, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 50 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 1 ~ 3 times obtained relative to the first step is the ethanol of 75 ~ 85%, and reflux 2 ~ 4 hours, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 3 ~ 5 times again, each decoction 1 ~ 3 hour, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 8 ~ 20%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 3 ~ 15%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 3%.

Wherein, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-4cm, soak 2-8 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40-60 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35-55 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

The invention has the beneficial effects as follows: medicine of the present invention, relieving convulsion with QI invigorating, tranquilizing the mind is Therapeutic Principle, holds concurrently with clear eliminating heart-fire, soothing the liver and network, nourishing kidney Rong Mu, holds up soil to consolidate, cure mainly type of deficiency of heart-QI and gallbladder-QI neurasthenia, processing technology is easy, little and the convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost,, in therapeutic process, there is not side effect in the through focus of energy.

Detailed description of the invention

For the corresponding symptom suffering from type of deficiency of heart-QI and gallbladder-QI neurasthenia appearance, the invention provides a kind of relieving convulsion with QI invigorating, tranquilizing the mind is Therapeutic Principle, hold concurrently with clear eliminating heart-fire, soothing the liver and network, nourishing kidney Rong Mu, the neurasthenic medicine for the treatment of type of deficiency of heart-QI and gallbladder-QI holding up soil to consolidate, wherein, medicine comprises following raw medicinal material: Radix Polygalae, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Concha Meretricis seu Cyclinae, Rhizoma Coptidis, Fructus Gardeniae, Herba Lophatheri, Concretio Silicea Bambusae, Caulis Akebiae, Semen Ziziphi Spinosae, Cortex Albiziae, Flos Celosiae Cristatae, Aspongopus, Endothelium Corneum Gigeriae Galli, Semen Oroxyli, Rhizoma Gastrodiae, Radix Sorghum vulgare Pers., succinum, Strobilus Cupressi, Lignum Poria, Rhodobryum roseum Limpr..Also comprise Sanguis Gallus domesticus, Gecko, Moschus.

We's compatibility is reasonable, rigorous, and relieving convulsion with QI invigorating, tranquilizing the mind be Therapeutic Principle, double with clear eliminating heart-fire, soothing the liver and network, nourishing kidney Rong Mu, hold up soil to consolidate.Treatment neurasthenia, can obtain desirable effect.Carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, addition or subtraction of changes, Radix Polygalae in its side, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Concha Meretricis seu Cyclinae, Radix Sorghum vulgare Pers., succinum, Strobilus Cupressi, Lignum Poria tranquillization with heavy prescription, to eliminate mind confusing; Rhizoma Coptidis, Fructus Gardeniae, Herba Lophatheri, Concretio Silicea Bambusae, the clear eliminating heart-fire of Caulis Akebiae; Semen Ziziphi Spinosae, Cortex Albiziae, Flos Celosiae Cristatae, Semen Oroxyli dispersing the stagnated live-QI to relieve the stagnation of QI; Rhizoma Gastrodiae nourishes blood and the flourish liver of blood; Aspongopus, Endothelium Corneum Gigeriae Galli regulating the flow of QI to alleviate depressionization are stagnant; Rhodobryum roseum Limpr., Sanguis Gallus domesticus, Gecko, Moschus vigorate qi and replenish the blood, promoting blood circulation to remove obstruction in the collateral.All medicines share, and it is relieving convulsion to play QI invigorating altogether, tranquilizing the mind, clear eliminating heart-fire, soothing the liver and network, nourishing kidney Rong Mu, the merit of holding up soil to consolidate.Make a general survey of full side, compatibility is rigorous.

Now the pharmacological properties effect of each taste medicine is described below:

Radix Polygalae: bitter, pungent, tepor; GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Shennong's Herbal: ", except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, normal hearing and eyesight, does not forget, strong will times power for main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency." " Japan hanako materia medica ": " the frightened black mole of main diaphragm gas, longue meat, helps muscles and bones, and married woman's blood is kept silent aphonia, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.Modern pharmacological research shows, comparatively skin zone is low for Radix Polygalae xylem haemolysis.Full Radix Polygalae, Radix Polygalae skin, the Radix Polygalae heart all can strengthen syngignoscism when same dosage; Anticonvulsant action is the strongest with full Radix Polygalae, and Radix Polygalae skin takes second place, and the Radix Polygalae heart is invalid; With Radix Polygalae skin the most by force, full Radix Polygalae is taken second place, and the Radix Polygalae heart is the most weak for haemolysis and anxious poison experiment; Full Radix Polygalae compares phlegm-dispelling functions with Radix Polygalae (core removed) and does not weaken.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury." not Lu " records it: " warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle skin ulcer.Audition improvement order, beneficial intelligence." Rhizoma Acori Graminei decoct takes the secretion of energy facilitating digestion liquid orally and prevents gastrointestinal abnormal fermentation, and has the effect alleviating intestinal tube smooth muscle spasm.The asaricin contained in Rhizoma Acori Graminei can resist the excitation of the intestine in vitro that barium chloride causes.

Os Draconis: sweet puckery is flat; Enter the heart, liver, kidney, large intestine channel.Function tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time." property of medicine opinion ": " by pathogen, tranquilizing mind, only cold-dysentery and defecation with blood and pus, woman's metrorrhagia leukorrhagia, only dream lets out essence, sexual intercourse in dream, controls hematuria, empty and dreaminess diverse and confused adding and use it." " Japan hanako materia medica ": " spleen invigorating, astringing intestine to stop diarrhea stomach, antidiarrheal dysentery, thirsty disease, conceived leakage tire, discharging fresh blood stool, metrorrhagia leukorrhagia, serious epistaxis, spits blood, hidroschesis." " Bencao Jingshu ": " Os Draconis puckery and main convergence, all dysentery intestinal of letting out are warded off and woman is leaked down the diseases such as metrorrhagia, hematuria, and all heat in blood stagnates as suffering from, and method, when tonneau catharsis, can not use only puckery agent, and probably stagnant blood stasis instead to be caused harm also interior.Only prolonged illness collapse person, not avoided." function tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.Promote blood clotting, reduce Vascular Permeability and suppress skeletal muscle excitation." Bencao Jingshu ": " Os Draconis puckery and main convergence, all dysentery intestinal of letting out are warded off and woman is leaked down the diseases such as metrorrhagia, hematuria, and all heat in blood stagnates as suffering from, and method, when tonneau catharsis, can not use only puckery agent, and probably stagnant blood stasis instead to be caused harm also interior.”

Concha Ostreae: salty, is slightly cold.Return liver, gallbladder, kidney channel.Function tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.Clothes of a specified duration should not be taken, in order to avoid cause constipation and dyspepsia more.Be suitable for having a delicate constitution edible after child, pulomonary hilar lymphoid tuberculosis, the tuberculosis of cervical lymph nodes, scrofula, the insomnia of deficiency of YIN dysphoria with smothery sensation, irritability, cancer and radiotherapy, chemotherapy; A kind of rare anticancer marine product, suitable edible as beauty food; The people of diabetic, sjogren syndrome, hypertension, arteriosclerosis, hyperlipemia eats; Menopausal syndrome and phenolics all should eat.

Concha Meretricis seu Cyclinae: salty, flat, bitter in the mouth; Enter the heart, kidney channel.Heat clearing away, diuretic, reduces phlegm, softening the hard mass.Control heat-phlegm to breathe heavily and cough, edema, gonorrhea, wart, tumor, gather, blood agglomeration chest pain, dysentery, hemorrhoid, metrorrhagia, leukorrhagia." Japan hanako materia medica ": " stopping vomiting is inverse, impotence, and breast coerces swollen urgency, lumbago, five hemorrhoid, married woman's metrorrhagia, leukorrheal diseases." " property of medicine opinion ": " air supporting of harnessing the river is swollen, and lower urine, controls inverse upper gas of coughing, tumor wart under item." heat clearing away, diuretic reduce phlegm, softening the hard mass.Control heat-phlegm to breathe heavily and cough, edema, gonorrhea, wart, tumor, gather, blood agglomeration chest pain, dysentery, hemorrhoid, metrorrhagia, leukorrhagia.The heat clearing away of this product cold energy, salty can softening the hard mass, therefore can clearing away lung-heat, change thick expectorant, the wart that disappears eliminating stagnation, the expectorant dyspnea of heat type caused for lung-heat is coughed, feeling of stuffiness in chest hypochondriac pain and the goiter caused by sucutaneous nodule, scrofula etc., and have inducing diuresis to remove edema, relieving gastric hyperacidity to alleviate stomachache effect, can be used for again the cards such as ascites, edema, stomachache acid regurgitation.

Rhizoma Coptidis: (root) is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, and have preventing or arresting vomiting concurrently and to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, heat in blood tells nosebleed, conjunctival congestion, has a toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated." Yaoxing Fu ": " bitter in the mouth, flat, gas is trembled with fear, nontoxic.Sink also, the moon also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears; Main intestinal Bleach is red except what mix in intestinal; Control order disease to break out and should use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, and have preventing or arresting vomiting concurrently and to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, heat in blood tells nosebleed, conjunctival congestion, has a toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.Shennong's Herbal: " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, the key medicine that calentura is vexed in order to control, restlessness is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the jaundice of available treating the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Herba Lophatheri: sweet, light, cold.GUIXIN, stomach, small intestine meridian.Effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome.Compendium of Material Medica: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome." vegetation is side just ": " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.Folium Bambosae extract is a kind of bioflavonoid health care nutrient newly developed, has excellent antiradical activities and conclusive quasi-SOD activity; Can compare favourably with VC to the blocking ability of nitrosation reaction; Effect and the pollen of defying age, anti-stress and resisting fatigue are suitable; Blood fat reducing and cholesterolemia, antioxidative effect are identical with Folium Ginkgo extract; Antibacterial, antiinflammatory is similar to tea polyphenols with antivirus action; Effect victory Succus Bambusae one of relieving cough and expelling phlegm, heat-clearing and toxic substances removing is raised; And there is significant immunological enhancement, the resistance of human body to poor environment and disease can be improved: the Folium Bambusae delicate fragrance also with good hydrothermal stability, antioxidative stabilizer and uniqueness.Not containing any harmful components and antinutritional factor, without toxicity, side effect, be a kind of very good pure natural health-care.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian.Function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough." Japan hanako materia medica ": " control middle wind-phlegm stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." " Kaibao Bencao ": " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.Fungus Zhuhuang water decoction extract 2-3.1g/kg subcutaneous injection, has good analgesic activity to mice acetic acid zest pain.Fungus Zhuhuang polysaccharide SB1 and SB2, through pharmacology preliminary test, has certain curative effect to hepatitis, and can dramatically and extend blood plasma recalcification time, in blood coagulation tests, this medicine can extend clotting time, may extend relevant with recalcification time.

Caulis Akebiae: bitter, cold in nature; Enter heart channel, small intestine meridian, urinary bladder channel." function inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow.For stranguria, edema, vexed dark coloured urine, amenorrhea breast is few, damp and hot arthralgia pain.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Collective Notes to the Canon of Materia medica: " Medulla Tetrapanacis, the present goes out shortcut, raw around timbo, and juice is white, and stem has pore, and two is all logical, blows it containing one, then to go out those persons good for gas.Or cloud and Weed rattan." " property of medicine opinion ": " cure mainly five types of stranguria, diuresis, switch lattice.Control people to sleep, main edema is floating large, heat clearing away and restlessness relieving more." function inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow.For stranguria, edema, vexed dark coloured urine, amenorrhea breast is few, damp and hot arthralgia pain.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Can the fire of supernatant heart channel, under let out the heat of small intestinal.

Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Shennong's Herbal: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup.Function " nourishing the liver, mind calming, calms the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; Excitation is had to uterus.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness; The empty hyperhidrosis of body.To rat, oral or lumbar injection all behaves with composure and somnolence Semen Ziziphi Spinosae decoct, no matter daytime or night, and Semen Ziziphi Spinosae all can show above-mentioned effect.

Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel.Dispersing the stagnated live-QI to relieve the stagnation of QI, calm the nerves, diuresis." Japan hanako materia medica ": " soft extracts, subduing inflammation reuniting the fractured tendons and bones." Shennong's Herbal: " Herba Albiziae, sweet in the mouth is put down.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneal mast cells retting conditions, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody generation process.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, Cortex Albiziae another name close confused skin, night platform skin, Herba Albiziae veneer, Cortex Albiziae has resolving depression of calming the nerves, the effect of eliminating carbuncle of invigorating blood circulation.

Flos Celosiae Cristatae: sweet, puckery, cool.Return liver, large intestine channel.Astringing to arrest bleeding, leukorrhagia stopping, dysentery relieving.For spitting blood, metrorrhagia, has blood in stool, hemorrhoidal bleeding, leucorrhea with red and white discharge, and chronic dysentery is more than." detailed outline ": " control anal fistula hematochezia, do white dysentery, metrorrhagia, also under leucorrhea, point red white use." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " only discharging fresh blood stool, married woman's metrorrhagia leukorrhagia, bloody dysentery." astringing to arrest bleeding, leukorrhagia stopping, dysentery relieving.For spitting blood, metrorrhagia, has blood in stool, hemorrhoidal bleeding, leucorrhea with red and white discharge, and chronic dysentery is more than.Its Seedling of Flos Celosiae Cristatae also has certain medicinal, can cure mainly the diseases such as hemorrhoid, dysentery, haematemesis, epistaxis, metrorrhagia, urticaria.

Semen Oroxyli: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the card such as carpopedal spasm pain of supporting, and paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.There are antithrombus formation and hepatoprotective effect, have inhibitory action to dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus.

Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, be mainly used in the dizzy headache of flaming up of liver-fire, the symptom such as strong wind tic, epilepsy that excessive rising of liver-YANG, liver-wind stirring up internally are caused.Compendium of Material Medica: " if treating the liver is empty through wind, only cleans, with l Water Paper bag, simmer ripe in bran fire, take out section, steeping in wine one night, dry use." there is suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, be mainly used in the dizzy headache of flaming up of liver-fire, the symptom such as strong wind tic, epilepsy that excessive rising of liver-YANG, liver-wind stirring up internally are caused.Rhizoma Gastrodiae is applicable to the dizziness caused by endogenous wind, but its to flu caused by headache and dizzy and be not suitable for.Rhizoma Gastrodiae also has calm, analgesic effect, and can increase cerebral blood flow, reduce cerebrovascular resistance, the effects such as slighter contraction cerebrovascular, can reduce blood pressure, slow down the rhythm of the heart, myocardial ischemia be played to the effect of protection.So Rhizoma Gastrodiae has certain effect to controlling cerebral thrombosis, but does not play decisive role.Rhizoma Gastrodiae embellishes but not dry, and master enters Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, the disease of all liver-wind stirring up internallys, the vertigo, no matter deficiency and excess, is key medicine.

Aspongopus: warm in nature, salty in the mouth; Return liver,spleen,kidney warp.Regulating QI to relieve pain, warming middle-JIAO is supporing yang." book on Chinese herbal medicine newly organized ": " Aspongopus, in worm to good person, enter ball loose in, weak the most suitable to hold up.But should not decoction be entered) sliding with its property, probably dynamic stool ear.The thing of Aspongopus also emerging sun, right non-Radix Ginseng.The Rhizoma Atractylodis Macrocephalae, Radix Morindae Officinalis.Herba Cistanches, Fructus Psoraleae and so on, also have no its large effect also." regulating QI to relieve pain, warming middle-JIAO is supporing yang.For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.Aspongopus has stronger antibacterial action to staphylococcus aureus, Bacillus typhi, Salmonella paratyphi, shigella flexneri; And have promotion body metabolism.

Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, enter spleen, stomach, small intestinal, urinary bladder channel, promoting digestion and invigorating the stomach, arresting seminal emission." Japan hanako materia medica ": " stopping leak essence, and hematuria, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition." have strengthening the spleen to promote digestion, arresting seminal emission to stop the effect of drowning, be mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation is suffered from diarrhoea, the symptoms such as infant malnutrition, and Endothelium Corneum Gigeriae Galli can promote gastric secretion, strengthens gastric peristalsis, accelerate the effects such as gastric emptying.Healthy People oral Grilled chicken Endothelium corneum powder 5g, through 45-60 minute, gastric secretion increases 30-37% than control value, recovers normal in 2 hours.Gastric acidity is also obviously increased.Endothelium Corneum Gigeriae Galli water decoction is got rid of radiostrontium to acceleration and is had certain effect.The food digesting action of Endothelium Corneum Gigeriae Galli be not medicine in the local action of gastric or directly stimulating intestine and stomach is kinetic, may be to enter blood after medicine digestion to stimulate gastric gland secretion increase and play indirect digestion-aid effect.

Radix Sorghum vulgare Pers.: be the root of grass chinese sorghum.Nature and flavor " Guizhou medical herbs ": " sweet in the mouth, property is put down." function cures mainly and relievings asthma, diuresis, hemostasis.Control cough and breathe heavily billows, gastric qi pain, metrorrhagia, postpartum hemorrhage.1. " detailed outline ": " liquor takes, diuresis, and Zhichuan is full; Ashing wine takes, and controls difficult labour." 2. " Guizhou medical herbs ": " clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.Tranquilizing the mind."

Succinum: nature and flavor are sweet is flat.1. " not Lu ": " sweet in the mouth is flat, nontoxic." 2. " Haiyao Bencao, Oversea Materia Medica ": " temperature." 3. " book on Chinese herbal medicine just ": " slightly sweet flavor, property is put down." return through entering the heart, liver, small intestine meridian.1. " Thunder God concocts property of medicine solution ": " enter the heart, spleen, small intestinal three warp." 2. " Bencao Jingshu ": " start with few the moon, sun, meridian of Foot-JUE YIN." function cures mainly tranquillizing the mind by relieving convulsion, and dissipating blood stasis stops blooding, relieving stranguria by diuresis.Control infantile convulsion epilepsy, palpitation with fear insomnia, stranguria with blood hematuria, urinary obstruction, women's amenorrhea, stop the stasis of blood stomachache puerperal, skin sore, traumatic injuries.1. " not Lu ": " main settling five organs, determines soul, repercussive blood, logical five types of stranguria." 2. " property of medicine opinion ": " manage property after blood stasis pain." 3. supplement to the Herbal: " hemostasia and promoting granulation, alloy skin ulcer." 4. " Japan hanako materia medica ": " high aspiration, improving eyesight mill nebula, only pained, insane heresy, broken combined symptoms." 5. " book on Chinese herbal medicine is not mentionleted alone ": " controls honor and diuretic of feeling at ease." 6. " pearl sac ": " diuresis, lung heat clearing." 7. " book on Chinese herbal medicine just ": " clear away heart-fire lung, repercussive blood, sputum." 8. " beautiful Chinese catalpa medicine solution ": " cool lung liver heat removing, mill is hidden from view, and spasmolytic is throbbed with fear, and except seminal emission nebulousurine, lower stillborn fetus afterbirth, deposited furuncle is drawn out pus by applying a plaster to the affected part, and relieving restlessness of quenching the thirst, habitual abortion expedites the emergence of."

Strobilus Cupressi: nature and flavor are pained is flat.1. " classify herbal ": " pained." 2. " Chongqing medical herbs ": " pungent micro-hardship of sweet in the mouth, property is put down, nontoxic." function cures mainly and dispels the wind, and calms the nerves, removing heat from blood, hemostasis.Cure cold and have a headache and fever, stomachache, irritated, spit blood.1. " classify herbal ": " relieving restlessness of calming the nerves." 2. " Traditional Chinese Medicine in Sichuan will ": " controls anemofrigid cold, stomachache and weak haematemesis." 3. " Chongqing medical herbs ": " separates ailment said due to cold or exposure, calms the nerves, hemostasis.Control heat in blood agitation, children's's cold and heat hyperpyrexia, spit blood."

Lignum Poria: nature and flavor are sweet is flat.1. " book on Chinese herbal medicine is looked for the truth ": " bitter in the mouth, warm in nature." 2. " key medicine divides agent ": " is sweet, flat, nontoxic." function cures mainly suppressing the hyperactive liver and calms the nerves.Control palpitation with fear forgetful, aphasia due to apoplexy, beriberi is had a cramp.1. " property of medicine opinion ": " control middle hemiplegia, facial palsy, malicious wind clonic spasm of the muscle, in silence, the mind is frightened pulls, empty and forgetful." 2. " detailed outline ": " controls beriberi arthralgia pain, and all muscle lead contracting." 3. " Chinese medicinal herbal ": " mind tranquilizing and the heart calming."

Rhodobryum roseum Limpr.: nature and flavor " choosing of Yunnan Chinese herbal medicine ": " light micro-hardship, flat." function cures mainly calmness of calming the nerves.Control that heart disease is nervous, cardiopalmus, neurasthenia.1. " choosing of Yunnan Chinese herbal medicine ": " calm, tonifying YANG." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " calmness of calming the nerves.Control nervous, cardiopalmus.Heart disease."

Sanguis Gallus domesticus: nature and flavor are salty is flat.1. " not Lu ": " flat, nontoxic." 2. " detailed outline ": " is salty, flat, nontoxic." 3. " medical center bun is wanted ": " cockscomb blood: salty, temperature." 4. " book on Chinese herbal medicine is new again ": " Sanguis Gallus domesticus: acrid in the mouth, hot in nature, nontoxic.Cockscomb blood: sweet in the mouth, warm in nature, nontoxic." returning through " book on Chinese herbal medicine is new again ": " enters the heart, liver two warp." " cockscomb blood: enter liver, lung, kidney three warp." function cure mainly dispel the wind, invigorate blood circulation, dredging collateral.Control infantile convulsion, facial palsy, flaccidity syndrome and arthralgia syndrome, injured, conjunctival congestion is shed tears, carbuncle skin ulcer tinea.1. " not Lu ": " male Gallus Domesticus blood: Zhu Wei rolls over osteodynia and flaccidity syndrome and arthralgia syndrome.Black female Sanguis Gallus domesticus: main attacked by pestiferous factors stomachache and Wei roll over osteodynia, and breast is difficult.Male Gallus Domesticus hat blood: main breast is difficult." 2. the Meng numerous: " order incessant lacrimation person, applies on order eyeball with 3 years male Gallus Domesticus hat blood, day three degree." 3. supplement to the Herbal: " horse stings skin ulcer and stripping donkey horse hinders hands, hot Sanguis Gallus domesticus and hot dipping it." " cock side of body blood: be coated with vitiligo, scrofula infections wind." 4. " varioliform exanthema is authentic ": " cockscomb blood and wine clothes, send out pox best." 5. " detailed outline ": " warm blood takes it, main children's's hematochezia and infantile convulsion, separates erysipelas, tranquilizing the mind." " male Gallus Domesticus hat blood also puts sudden and violent Akamu.Red chicken person also treats wind heat between meridians; It is askew not just that painting cheek controls mouth; The children's soldier that controls of soldier's drink shies infantile convulsive seizure due to fright; Be coated with all skin ulcer tinea, Scolopendra, spider venom, horse nibbles skin ulcer, insects entering the ear.It is withered, hot-tempered that " 6. " book on Chinese herbal medicine is new again ": " controls painstaking effort, sharp joint, the meridian dredging.The treating blood disorders of holding concurrently of " " cockscomb blood divides edema caused by disorder of QI, and depletion of blood can be given birth to, and blood to be broken; Gas is weak to be mended, and QI rising in reverse order can be relaxed; Invigorating middle warmer kidney tonifying, diuretic stimulates the menstrual flow."

Gecko: nature and flavor are salty, flat.1. " Kaibao Bencao ": " salty in the mouth is flat." 2. " herbal classic is met former ": " sweet one-tenth, temperature." return through entering lung, kidney channel.1. " Bencao Jingshu ": " lunar, meridian of Foot-SHAO YIN of starting with." 2. " book on Chinese herbal medicine converges and says ": " lunar, JUE YIN meridian of starting with." 3. " book on Chinese herbal medicine is new again ": " enters the heart, kidney two warp." function cures mainly invigorating the lung and the kidney, Dingchuan antitussive.Control asthenia, consumptive lung disease, breathe heavily and cough, spitting of blood, quenches one's thirst, sexual impotence.1. " Haiyao Bencao, Oversea Materia Medica ": " treat injured, gas in main consumptive lung disease, spitting of blood cough." 2. " Japan hanako materia medica ": " controls lung qi, antitussive, and logical menstruation, lower stranguria caused by urinary stone and control blood." 3. " Kaibao Bencao ": " main impairment of the lung caused by overstrain of a specified duration, treats cough, lower pouring drop, waterway." 4. amplification on Canon of Materia Medica: " tonifying the lung asthenia is coughed meritorious." 5. " detailed outline ": " tonifying the lung gas, benefiting essence-blood, Dingchuan antitussive, treats lung abscess and quenches one's thirst, supporing yang road." 6. " book on Chinese herbal medicine is new again ": " warming middle-JIAO kidney tonifying, controlling nocturnal emission with astringent drugs is supporing yang, treating stranguria, promoting the circulation of blood.Gecko end can control hernia."

Moschus: nature and flavor are pungent, temperature.Return through GUIXIN, spleen channel.Function cures mainly refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea ， WEIJIA, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain, falls and flutter the pain of injury, and arthralgia pain is numb.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

Radix Polygalae 45 parts, Rhizoma Acori Graminei 20 parts, Os Draconis 14 parts, Concha Ostreae 23 parts, Concha Meretricis seu Cyclinae 15 parts, Rhizoma Coptidis 30 parts, Fructus Gardeniae 25 parts, Herba Lophatheri 20 parts, Concretio Silicea Bambusae 25 parts, Caulis Akebiae 3 parts, Semen Ziziphi Spinosae 20 parts, Cortex Albiziae 30 parts, Flos Celosiae Cristatae 20 parts, Aspongopus 25 parts, Endothelium Corneum Gigeriae Galli 12 parts, Semen Oroxyli 5 parts, 20 parts, Rhizoma Gastrodiae, Radix Sorghum vulgare Pers. 23 parts, succinum 6 parts, Strobilus Cupressi 10 parts, Lignum Poria 4 parts, Rhodobryum roseum Limpr. 10 parts.

Its preparation method is:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.12 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.01 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 capsule

Radix Polygalae 45 parts, Rhizoma Acori Graminei 20 parts, Os Draconis 14 parts, Concha Ostreae 23 parts, Concha Meretricis seu Cyclinae 15 parts, Rhizoma Coptidis 30 parts, Fructus Gardeniae 25 parts, Herba Lophatheri 20 parts, Concretio Silicea Bambusae 25 parts, Caulis Akebiae 3 parts, Semen Ziziphi Spinosae 20 parts, Cortex Albiziae 30 parts, Flos Celosiae Cristatae 20 parts, Aspongopus 25 parts, Endothelium Corneum Gigeriae Galli 12 parts, Semen Oroxyli 5 parts, 20 parts, Rhizoma Gastrodiae, Radix Sorghum vulgare Pers. 23 parts, succinum 6 parts, Strobilus Cupressi 10 parts, Lignum Poria 4 parts, Rhodobryum roseum Limpr. 10 parts, Sanguis Gallus domesticus 6 parts, Gecko 4 parts, 10 parts, Moschus.

Its preparation method is:

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 50 minutes, be ground into smalls, be screened into 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 times obtained relative to the first step is the ethanol of 85%, and reflux 4 hours, extracts 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 5 times again, and each decoction 3 hours, decocts 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mixes with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract;

3rd step, is broken into 200 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 20%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 15%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 3%.

Embodiment 3 decoction

Its preparation method is:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 4cm, soak 8 hours;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 60 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 3 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 55 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Toxicity test

1. acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Tablet prepared by embodiments of the invention 1 is pulverized and is dissolved in water, (concentration is 6.4g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32g crude drug/kg of the present invention, every day, maximum dosage-feeding was 64g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 771 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

2. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the decoction of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.2LD50,0.3LD50,0.4LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,1000,1500,2000,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Medicine of the present invention is described, does not there is cumulative toxicity.

Clinical trial

Treatment target: patient neurasthenia 200 example selecting first three grades of institute's department of neurology medical, Symptoms is: dysphoria and insomnia, dreaming often and waking easily, timidity and palpitation, and tactile thing is easily shied, and with spontaneous perspiration of breathing hard, fatigue and weakness, light red tongue, stringy pulse, dialectical is type of deficiency of heart-QI and gallbladder-QI neurasthenia.Man's 99 cases, female patient 101 example.Be divided into four groups at random, treat one group, treat two groups, treat three groups and matched group.Age, the course of disease are without very large gap.

Diagnostic criteria

Neurasthenia is a kind of dysfunction sexually transmitted disease (STD) disease, and clinical symptoms performance is various, but will diagnose primary disease, should possess following five features:

(1) neurastheniac has fatigue symptom weak or lasting significantly.

(2) any two in following symptom are showed:

1. easy excitement fatiguability again.

2. anxious state of mind is large, when anything crops up passionnate, irritable, worries and nervous.

3. because of nervous engender tension headache or myalgia.

4. sleep disorder.Show as difficulty falling asleep, easily wake up with a start, dreaminess.

(3) above-mentioned situation causes harmful effect to study, work and social communication.

(4) course of disease is more than 3 months.

(5) other neurosiss and psychosis is eliminated.

(6) type of deficiency of heart-QI and gallbladder-QI: dysphoria and insomnia, dreaming often and waking easily, timidity and palpitation, tactile thing is easily shied, with spontaneous perspiration of breathing hard, fatigue and weakness, light red tongue, stringy pulse.

Therapeutic Method:

Treat one group: this is organized 50 people and uses the tablet of embodiments of the invention 1 to treat.Every day 2 times, each 1 30 days is a course for the treatment of, and 1 course for the treatment of is carried out in treatment.

Treat two groups: this is organized 50 people and uses the capsule of embodiments of the invention 2 to treat.Every day 2 times, each 1 30 days is a course for the treatment of, and 1 course for the treatment of is carried out in treatment.

Treat three groups: this is organized 50 people and uses the decoction of embodiments of the invention 3 to treat.Every day 2 times, each 30ml 30 days is a course for the treatment of, and 1 course for the treatment of is carried out in treatment.

Matched group: this is organized 50 people and uses Xinshen Ning tablets to treat.Oral, one time 4 ~ 6,3 times on the one.Within 30 days, be a course for the treatment of, 1 course for the treatment of is carried out in treatment.

Criterion of therapeutical effect

With the evaluation of neurasthenia's Self-assessment Scale, adopt sub-anti-symmetrical matrix to evaluate Drug side reaction, judge clinical efficacy according to neurasthenia's Self-assessment Scale total score deduction rate, deduction rate >=75% is recovery from illness, >=50% is effective, and >=25 % are that effectively <25% is severity of symptoms or invalid.Recovery from illness+effective+effectively=always effective.

Therapeutic outcome

Table 1 is the treatment situation contrast of each group

Group	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
						Treat one group	47（94%）	1（2%）	2（4%）	0（0%）	100%
Treat two groups	48（96%）	1（2%）	1（2%）	0（0%）	100%
						Treat three groups	49（98%）	1（2%）	0（0%）	0（0%）	100%
Matched group	35（70%）	5（10%）	5（10%）	5（10%）	90%

As can be seen from Table 1, the treatment situation of three treatment groups is better than matched group.It can thus be appreciated that, medicine of the present invention, treatment type of deficiency of heart-QI and gallbladder-QI neurasthenia, good effect, determined curative effect.

The side effect that table 2 is each group occurs that situation contrasts

Group	There is number in side effect	Side effect occurrence rate
			Treat one group	0	0
Treat two groups	0	0
			Treat three groups	0	0
Matched group	10	20%

As can be seen from Table 2, in the therapeutic process of three treatment groups, there is not any side effect, it can thus be appreciated that medicine of the present invention, treatment type of deficiency of heart-QI and gallbladder-QI neurasthenia, safety has no side effect.

In sum, medicine of the present invention, treatment type of deficiency of heart-QI and gallbladder-QI neurasthenia, good effect, determined curative effect, and have no side effect, safe and effective.

Model case: in February, 2014, the medical grandson of first three grades of institute's department of neurology, man, 35 years old, be diagnosed as type of deficiency of heart-QI and gallbladder-QI neurasthenia.The decoction of embodiments of the invention 3 is used to treat.Every day 2 times, each 30ml 30 days is a course for the treatment of, and 1 course for the treatment of is carried out in treatment.Recovery from illness.In therapeutic process, without any side effect, later stage follow-up is not recurred half a year.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. the neurasthenic medicine for the treatment of type of deficiency of heart-QI and gallbladder-QI, it is characterized in that, described medicine comprises following raw medicinal material: Radix Polygalae, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Concha Meretricis seu Cyclinae, Rhizoma Coptidis, Fructus Gardeniae, Herba Lophatheri, Concretio Silicea Bambusae, Caulis Akebiae, Semen Ziziphi Spinosae, Cortex Albiziae, Flos Celosiae Cristatae, Aspongopus, Endothelium Corneum Gigeriae Galli, Semen Oroxyli, Rhizoma Gastrodiae, Radix Sorghum vulgare Pers., succinum, Strobilus Cupressi, Lignum Poria, Rhodobryum roseum Limpr..

2. medicine according to claim 1, it is characterized in that, the weight part ratio of described raw medicinal material is: Radix Polygalae 35-45 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Os Draconis 10-14 weight portion, Concha Ostreae 12-23 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Rhizoma Coptidis 25-30 weight portion, Fructus Gardeniae 20-25 weight portion, Herba Lophatheri 10-20 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Caulis Akebiae 3-7 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Cortex Albiziae 25-30 weight portion, Flos Celosiae Cristatae 10-20 weight portion, Aspongopus 15-25 weight portion, Endothelium Corneum Gigeriae Galli 12-21 weight portion, Semen Oroxyli 5-10 weight portion, Rhizoma Gastrodiae 20-24 weight portion, Radix Sorghum vulgare Pers. 15-23 weight portion, succinum 6-13 weight portion, Strobilus Cupressi 10-20 weight portion, Lignum Poria 4-7 weight portion, Rhodobryum roseum Limpr. 10-20 weight portion.

3. medicine according to claim 1, it is characterized in that, also comprise Sanguis Gallus domesticus, Gecko, Moschus moschiferous is fragrant, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 35-45 weight portion, Rhizoma Acori Graminei 10-20 weight portion, Os Draconis 10-14 weight portion, Concha Ostreae 12-23 weight portion, Concha Meretricis seu Cyclinae 10-15 weight portion, Rhizoma Coptidis 25-30 weight portion, Fructus Gardeniae 20-25 weight portion, Herba Lophatheri 10-20 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Caulis Akebiae 3-7 weight portion, Semen Ziziphi Spinosae 15-20 weight portion, Cortex Albiziae 25-30 weight portion, Flos Celosiae Cristatae 10-20 weight portion, Aspongopus 15-25 weight portion, Endothelium Corneum Gigeriae Galli 12-21 weight portion, Semen Oroxyli 5-10 weight portion, Rhizoma Gastrodiae 20-24 weight portion, Radix Sorghum vulgare Pers. 15-23 weight portion, succinum 6-13 weight portion, Strobilus Cupressi 10-20 weight portion, Lignum Poria 4-7 weight portion, Rhodobryum roseum Limpr. 10-20 weight portion, Sanguis Gallus domesticus 6-13 weight portion, Gecko 4-8 weight portion, Moschus 10-14 weight portion.

4. medicine according to claim 1 and 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 45 weight portion, Rhizoma Acori Graminei 20 weight portion, Os Draconis 14 weight portion, Concha Ostreae 23 weight portion, Concha Meretricis seu Cyclinae 15 weight portion, Rhizoma Coptidis 30 weight portion, Fructus Gardeniae 25 weight portion, Herba Lophatheri 20 weight portion, Concretio Silicea Bambusae 25 weight portion, Caulis Akebiae 3 weight portion, Semen Ziziphi Spinosae 20 weight portion, Cortex Albiziae 30 weight portion, Flos Celosiae Cristatae 20 weight portion, Aspongopus 25 weight portion, Endothelium Corneum Gigeriae Galli 12 weight portion, Semen Oroxyli 5 weight portion, Rhizoma Gastrodiae 20 weight portion, Radix Sorghum vulgare Pers. 23 weight portion, succinum 6 weight portion, Strobilus Cupressi 10 weight portion, Lignum Poria 4 weight portion, Rhodobryum roseum Limpr. 10 weight portion.

5. the medicine according to claim 1 or 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix Polygalae 45 weight portion, Rhizoma Acori Graminei 20 weight portion, Os Draconis 14 weight portion, Concha Ostreae 23 weight portion, Concha Meretricis seu Cyclinae 15 weight portion, Rhizoma Coptidis 30 weight portion, Fructus Gardeniae 25 weight portion, Herba Lophatheri 20 weight portion, Concretio Silicea Bambusae 25 weight portion, Caulis Akebiae 3 weight portion, Semen Ziziphi Spinosae 20 weight portion, Cortex Albiziae 30 weight portion, Flos Celosiae Cristatae 20 weight portion, Aspongopus 25 weight portion, Endothelium Corneum Gigeriae Galli 12 weight portion, Semen Oroxyli 5 weight portion, Rhizoma Gastrodiae 20 weight portion, Radix Sorghum vulgare Pers. 23 weight portion, succinum 6 weight portion, Strobilus Cupressi 10 weight portion, Lignum Poria 4 weight portion, Rhodobryum roseum Limpr. 10 weight portion, Sanguis Gallus domesticus 6 weight portion, Gecko 4 weight portion, Moschus 10 weight portion.

6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is capsule, and its preparation method comprises the following steps:

8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps: