CN103705639A - Chinese medicinal preparation for treating hydrocephalus - Google Patents
Chinese medicinal preparation for treating hydrocephalus Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for treating hydrocephalus, belonging to the field of Chinese medicaments. The Chinese medicinal preparation consist of the following active ingredients of the raw materials: angelica root, agaric, kudzu root, fructus lycii, tree peony bark, chamomile, scutellaria root, peach kernel, costus root, ephedra, salsola collina, mulberry, cassia bark, polygonum cuspidatum, storax and radix sophorae flavescentis. The Chinese medicinal preparation has the effects of clearing away heat, reducing fire, clearing damp, promoting diuresis, eliminating phlegm for resuscitation, soothing nerves and promoting intelligence, has significant curative effects on intracranial hypertension caused by hydrocephalus, bilateral tempora or full skull pains, nausea, cephaledema or optic atrophy and the like, has good treatment effects on the symptoms including disorders of mental development, dyskinesia, psychonosema, forgetfulness and the like, is short in treatment course, quick in response and low in cost, does not have any toxic or side effect and is worthy of clinical wide popularization and application.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of hydrocephalic Chinese medicine preparation for the treatment of.
Background technology
Hydrocephalus is to increase because brain disorder makes cerebrospinal fluid supersecretion or circulation, malabsorption causes intracranial cerebrospinal fluid amount, a kind of disease that Decrease density plaques or subarachnoid space expand, its classical symptom is headache, vomiting, blurred vision, papilloedema, even companion's diplopia, dizzy and epilepsy.
After hydrocephalus forms, cerebrospinal fluid circulation path is obstructed and causes that cerebral tissue Secondary cases changes, and it shows as ventricular system because gathering of cerebrospinal fluid expanded, along with ventricles of the brain wall is subject to tractive, ependyma fades away, and periventrcular is spider cell or colloid cicatrization; The ventricles of the brain further expand, and can make cerebrospinal fluid enter chamber week tissue and cause white matter edema, even if row by-pass operation of cerebrospinal fluid at this moment makes the ventricles of the brain return to normal size, the change of cerebral tissue on histology can not recover; If hydrocephalus further develops, the attenuation of cerebral cortex pressurized, can secondary brain atrophy, and the expansion of ventriculus tertius can make hypothalamus pressurized and atrophy, and middle compression of brain makes the eyeball generation obstacle that moves both vertically, and occurs " setting-sun sign " of clinical findings.
The intracranial hypertension that hydrocephalus causes can make bilateral lateral sinus pressurized, and the blood flow that injects both sides internal jugular vein is obstructed, thereby can occur that the blood backflow of compensatory external jugular vein system increases, and secondary scalp vein anger is opened.
The medically normal method treatment that adopts operation at present, expense is high, and side effect is large, and restricted application, for clinical a certain symptom treatment, often falls flat, and can not find suitable Therapeutic Method.
Summary of the invention
The invention provides a kind of hydrocephalic Chinese medicine preparation for the treatment of; This present invention Chinese medicine preparation has clearing away heat-fire, promoting diuresis to eliminate damp pathogen, the effect of the eliminating phlegm of having one's ideas straightened out, the Fructus Alpiniae Oxyphyllae of calming the nerves, the intracranial hypertension causing for treatment hydrocephalus, bilateral temples or full cranium pain, the cephaledema of feeling sick or optic atrophy etc. are evident in efficacy, for symptoms such as intelligent development obstacle, dyskinesia, mental disorder, hypomnesis, all there is good therapeutic effect, and short treating period, instant effect, cost are low, without any side effects, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a hydrocephalic Chinese medicine preparation, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
48～83 parts of 53～83 parts of Fructus Lycii of 53～88 parts of Radix Puerariaes of 63～88 portions of Auricularias of the Radix Angelicae Dahuricae
38～73 parts, 43～73 parts of Semen Persicaes of 43～78 parts of Radix Scutellariaes of 43～83 parts of Flos Chrysanthemis of Cortex Moutan
28～58 parts of 33～58 parts of Fructus Mori of 33～63 parts of Herba Salsolae Collinaes of 38～68 portions of Herba Ephedraes of the Radix Aucklandiae
18～43 parts of 18～48 parts of Radix Sophorae Flavescentiss of 23～48 parts of Styrax of 23～53 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
53～78 parts of 58～78 parts of Fructus Lycii of 58～83 parts of Radix Puerariaes of 68～83 portions of Auricularias of the Radix Angelicae Dahuricae
43～68 parts, 48～68 parts of Semen Persicaes of 48～73 parts of Radix Scutellariaes of 48～78 parts of Flos Chrysanthemis of Cortex Moutan
33～53 parts of 38～53 parts of Fructus Mori of 38～58 parts of Herba Salsolae Collinaes of 43～63 portions of Herba Ephedraes of the Radix Aucklandiae
23～38 parts of 23～43 parts of Radix Sophorae Flavescentiss of 28～43 parts of Styrax of 28～48 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
58～73 parts of 63～73 parts of Fructus Lycii of 63～78 parts of Radix Puerariaes of 73～78 portions of Auricularias of the Radix Angelicae Dahuricae
48～63 parts, 53～63 parts of Semen Persicaes of 53～68 parts of Radix Scutellariaes of 53～73 parts of Flos Chrysanthemis of Cortex Moutan
38～48 parts of 43～48 parts of Fructus Mori of 43～53 parts of Herba Salsolae Collinaes of 48～58 portions of Herba Ephedraes of the Radix Aucklandiae
28～33 parts of 28～38 parts of Radix Sophorae Flavescentiss of 33～38 parts of Styrax of 33～43 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
66 parts of 68 parts of Fructus Lycii of 70 parts of Radix Puerariaes of 75 portions of Auricularias of the Radix Angelicae Dahuricae
55 parts, 58 parts of Semen Persicaes of 63 parts of Radix Scutellariaes of 63 parts of Flos Chrysanthemis of Cortex Moutan
43 parts of 45 parts of Fructus Mori of 48 parts of Herba Salsolae Collinaes of 53 portions of Herba Ephedraes of the Radix Aucklandiae
31 parts of 33 parts of Radix Sophorae Flavescentiss of 35 parts of Styrax of 38 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
Treat a preparation method for hydrocephalic Chinese medicine preparation, comprise following processing step:
(1) Radix Angelicae Dahuricae, Auricularia, Radix Puerariae, Styrax and Radix Sophorae Flavescentis decontamination are dried, be placed in mortar and grind into powder, cross 200 order fine powders, standby;
(2) Fructus Lycii, Semen Persicae, Herba Salsolae Collinae and Rhizoma Polygoni Cuspidati are cleaned, immersed 75% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and is condensed into the thick paste that at 60 ℃, relative density is 1.20～1.25, standby;
(3) Cortex Moutan, Flos Chrysanthemi, Radix Scutellariae, the Radix Aucklandiae and Cortex Cinnamomi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 65 ℃, relative density is 1.10～1.12, standby;
(4) get Herba Ephedrae decontamination and put into container, select the refined honey of 0.5 times of amount to add after certain amount of boiling water dilution, drench in Herba Ephedrae and mix thoroughly, moistening, taking-up is placed in parch container, with slow fire heating, fries to buff and when tack-free, take out dry in the air cool, be placed in mortar and grind into powder, cross 160 order fine powders, standby;
(5) Fructus Mori are cleaned, put into container, strand juice, elimination impurity, stays juice standby;
(6) above-mentioned steps (1)～(5) prepared fine powder, thick paste and juice are mixed, utilize modern advanced pharmacy science and technology, make tablet, obtain the hydrocephalic Chinese medicine preparation for the treatment of of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Enter lung, spleen, stomach warp.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Cure mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.< < detailed outline > > carries: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, married woman's blood dizziness due to wind pathogen fortune, bleeding urine, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound.”
Auricularia: sweet in the mouth, property is flat, slightly poisonous.Modern medicine study confirmation, Auricularia is applicable to cardiovascular and cerebrovascular disease, calculosis edible for patients, and the personage, miner, metallurgical workman, weaving work, the hairdresser that are particularly suitable for iron deficiency are edible.
Radix Puerariae: sweet in the mouth, pungent, cool in nature; Enter spleen, stomach warp.Induce sweat and bring down a fever, the rash of promoting the production of body fluid, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels.< < Compendium of Materia Medica > > carries: " Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling." modern medicine study shows, the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.
Fructus Lycii: sweet in the mouth, property is flat; Return liver, kidney, lung meridian.Nourishing the liver, nourishing kidney, lung moistening.Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely of quenching one's thirst.< < Compendium of Materia Medica > > carries: " take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant summer-heat.The traditional Chinese medical science conventional it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission." modern pharmacology studies confirm that, Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has the effect of the aspects such as slow down aging, anti-fatty liver, adjusting blood fat and blood glucose, promotion hemopoietic function, and is applied to clinical.
Cortex Moutan: bitter in the mouth, cool, cold nature; GUIXIN, liver, kidney, lung meridian.Clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, sends out speckle, tells nosebleed, and the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury, rheumatism pyretic arthralgia.< < Compendium of Materia Medica > > carries: " nourishing YIN to lower pathogenic fire is separated speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, the contained paeonol of Cortex Moutan and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has inhibition Platelet; Paeonol has the effects such as the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and atherosclerosis, diuresis, antiulcer.
Flos Chrysanthemi: bitter in the mouth, pungent, cold nature.The liver benefiting nourishing YIN, clearing heat and expelling damp, energy suppressing the hyperactive liver fire, puts out endogenous wind, presses down the perverse and unreasonable manner of wood gas.< < herbal classic > > carries: " main air dizziness person, with floating of YANG due to deficiency of YIN, the ascension of gas fire, the dizzy speech of disturbing on liver phoenix it, non-external ailment said due to cold or exposure, can make us also dizzy.Liver-fire directly goes up summit, and is dizzy, for swollen, is pain, and positive flame is gone straight up to, and its gesture is the most sudden and the most violent.”
Radix Scutellariae: bitter in the mouth, cold in nature; Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, the diseases such as carbuncle furuncle.The positive > > of < < book on Chinese herbal medicine carries: " fire of the clear part of the body cavity above the diaphragm housing the heart and lungs of withered person, expectorant promoting the circulation of QI, relieving asthma and cough; only lose blood, move back alternate attacks of chills and fever, and wind heat is damp and hot; headache; separate pestilence, and moistening and cleaning throat is treated consumptive lung disease lung abscess; acute mastitis carbuncle on the back; the heat of outstanding method flesh table, therefore control macule, scrofula, skin infection, acute conjunctivitis; The heat of the cool part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of reality person, can remove bloody dysentery, and heat is held bladder, the puckery pain of five types of stranguria, and large intestine closes knot, has blood in stool, leaks blood." modern medicine study confirms, Radix Scutellariae has significantly the effects such as antibacterial, antifungal, antiviral, antiinflammatory, antiallergic action, can reduce blood pressure, anticoagulant, anticoagulant, blood fat reducing, protects the liver in addition in addition, function of gallbladder promoting, antioxidation, anticancer function.
Semen Persicae: bitter in the mouth, sweet, property is flat; GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Cure mainly amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.< < herbal classic meets former > > to carry: " Semen Persicae, the special medicine closing for blood stasis blood.Bitter to let out stagnant blood, sweetly with tissue regeneration promoting blood, control invasion of the blood-chamber by heat, the stasis of blood amass lump in the abdomen, malaria with splenomegaly, cardiac and abdominal pain, the blood agglomeration of the Liver Channel that also falls apart." modern medicine study confirmation, Semen Persicae alcohol extract can increase vein blood vessel flow, vasodilator, and can increase femoral artery blood flow, and reduce vascular resistance, blood vessel wall is had to direct dilating effect, suppress in addition in addition blood coagulation and haemolysis.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature; Return spleen, large intestine, tri-jiao channel.Promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune.Main born of the same parents coerce distension foot, tell and have loose bowels, heavy after dysentery, heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.< < detailed outline > > carries: " Radix Aucklandiae, is the medicine of three warmers edema caused by disorder of QI, can all gas of lifting.All gas Fen are strongly fragrant, all belong to lung, thus the person that QI stagnating in upper-JIAO is used, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the suitable person of QI stagnating in middle-JIAO, taste happiness fragrance also; QI stagnation of the large intestine is heavy afterwards, and bladder gas is not changed infirmity pouring, and hepatic depression be pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug lead to also.”
Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature; Return lung, urinary bladder channel.Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For affection of exogenous wind-cold, fever with aversion to cold, head, body pain, nasal obstruction, lossless, floating and tense pulse etc.Modern medicine study confirms, this product energy lung qi dispersing gas, and loosing the interspaces of skin and muscles, dispersing wind and cold, with relieving the exterior syndrome by diaphoresis.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > > carries: " control that stuffy nose is obstructed, good and foul smells not to be heard, lung cold cough.”
Herba Salsolae Collinae: lightly seasoned, cool in nature; Return Liver Channel.Suppressing the hyperactive liver and subsiding YANG, loosening bowel to relieve constipation.Cure mainly hypertension, dizzy, insomnia, dryness of the intestine constipation.< < Hebei Chinese medicine handbook > > carries: " blood pressure lowering.Control hypertension, headache.”
Fructus Mori: sweet in the mouth, acid, cold in nature; GUIXIN, liver, kidney channel.The YIN nourishing of enriching blood, promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.< < Bencao Jingshu > > carries: " Fructus Mori, sweet cold beneficial blood and heat extraction are the enrich blood medicine of tonifying YIN of removing heat from blood.Quench one's thirst due to interior-heat, deficiency of body fluid, quenches the thirst therefore promote the production of body fluid.It is cloudy that the five internal organs all belong to, and therefore tonifying YIN is sharp the five internal organs.The deficiency of YIN vim and vigour in joint is obstructed, and blood promotes the production of body fluid full, and cloudy gas is long to be contained, and not hungry and vim and vigour are from logical.It is raw that heat is moved back the moon, and the liver heart is without fire, therefore soul is pacified, god is certainly peaceful clearly, and god is clever interior sending out clearly, and the moon bleaches not old again.”
Cortex Cinnamomi: acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Cure mainly decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.< < does not record > > and carries: " main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspiration.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, stops saliva, cough ， Bi Weng; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing institute is feared.”
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature; Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis is not Xiaed ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.< < Guizhou side's medicine among the people collection > > carries: " astringing to arrest bleeding, controls hemorrhoid complicated by anal fistula, and curing rheumatism is delivered cold expelling, dissipating blood stasis blood, and burn is controlled in external.”
Styrax: acrid in the mouth, warm in nature; GUIXIN, spleen channel.Have one's ideas straightened out, ward off dirty, pain relieving.For apoplexy syncope due to accumulation of phlegm, suddenly faint, breast abdomen cold type of pain, infantile convulsion.The beautiful Chinese catalpa medicine of < < solution > > carries: " inducing diuresis to remove edema, control swollen, rash miliaria, QI-mass mass formed by blood stasis, is in harmonious proportion internal organs.”
Radix Sophorae Flavescentis: bitter in the mouth, taste is cold; GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing away, dampness, parasite killing.Cure mainly intermittent fever and go mad, pyretic toxicity blocked-up chest, quenches one's thirst, damp-heat dysentery, discharging fresh blood stool, leukorrhagia pudendal pruritus, jaundice, hot urination, rubella pruritus, scabies, leprosy, noxious dampness skin infection.< < Sheng Nong's herbal classic > > carries: " jaundice, drowns and has the heeltap for main stagnation of QI in chest and abdomen, lump in the abdomen, relieve oedema or abdominal distension through diuresis or purgation, and except carbuncle, invigorating middle warmer, improving eyesight arresting lacrimation.”
The present invention compared with prior art, has following beneficial effect:
This present invention Chinese medicine preparation has clearing away heat-fire, promoting diuresis to eliminate damp pathogen, the effect of the eliminating phlegm of having one's ideas straightened out, the Fructus Alpiniae Oxyphyllae of calming the nerves, the intracranial hypertension causing for treatment hydrocephalus, bilateral temples or full cranium pain, the cephaledema of feeling sick or optic atrophy etc. are evident in efficacy, for symptoms such as intelligent development obstacle, dyskinesia, mental disorder, hypomnesis, all there is good therapeutic effect, and short treating period, instant effect, cost are low, without any side effects, wide popularization and application on clinic.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Radix Angelicae Dahuricae 83g Auricularia 83g Radix Puerariae 78g Fructus Lycii 78g
Cortex Moutan 78g Flos Chrysanthemi 73g Radix Scutellariae 68g Semen Persicae 68g
Radix Aucklandiae 63g Herba Ephedrae 58g Herba Salsolae Collinae 53g Fructus Mori 53g
Cortex Cinnamomi 48g Rhizoma Polygoni Cuspidati 43g Styrax 43g Radix Sophorae Flavescentis 38g.
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) Radix Angelicae Dahuricae, Auricularia, Radix Puerariae, Styrax and Radix Sophorae Flavescentis decontamination are dried, be placed in mortar and grind into powder, cross 200 order fine powders, standby;
(2) Fructus Lycii, Semen Persicae, Herba Salsolae Collinae and Rhizoma Polygoni Cuspidati are cleaned, immersed 75% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and is condensed into the thick paste that at 60 ℃, relative density is 1.20～1.25, standby;
(3) Cortex Moutan, Flos Chrysanthemi, Radix Scutellariae, the Radix Aucklandiae and Cortex Cinnamomi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 65 ℃, relative density is 1.10～1.12, standby;
(4) get Herba Ephedrae decontamination and put into container, select the refined honey of 0.5 times of amount to add after certain amount of boiling water dilution, drench in Herba Ephedrae and mix thoroughly, moistening, taking-up is placed in parch container, with slow fire heating, fries to buff and when tack-free, take out dry in the air cool, be placed in mortar and grind into powder, cross 160 order fine powders, standby;
(5) Fructus Mori are cleaned, put into container, strand juice, elimination impurity, stays juice standby;
(6) above-mentioned steps (1)～(5) prepared fine powder, thick paste and juice are mixed, utilize modern advanced pharmacy science and technology, make tablet, obtain the hydrocephalic Chinese medicine preparation for the treatment of of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, severe one can be fully recovered 3～4 courses for the treatment of.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Radix Angelicae Dahuricae 78g Auricularia 78g Radix Puerariae 73g Fructus Lycii 73g
Cortex Moutan 73g Flos Chrysanthemi 68g Radix Scutellariae 63g Semen Persicae 63g
Radix Aucklandiae 58g Herba Ephedrae 53g Herba Salsolae Collinae 48g Fructus Mori 48g
Cortex Cinnamomi 43g Rhizoma Polygoni Cuspidati 38g Styrax 38g Radix Sophorae Flavescentis 33g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Radix Angelicae Dahuricae 75g Auricularia 70g Radix Puerariae 68g Fructus Lycii 66g
Cortex Moutan 63g Flos Chrysanthemi 63g Radix Scutellariae 58g Semen Persicae 55g
Radix Aucklandiae 53g Herba Ephedrae 48g Herba Salsolae Collinae 45g Fructus Mori 43g
Cortex Cinnamomi 38g Rhizoma Polygoni Cuspidati 35g Styrax 33g Radix Sophorae Flavescentis 31g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Radix Angelicae Dahuricae 73g Auricularia 63g Radix Puerariae 63g Fructus Lycii 58g
Cortex Moutan 53g Flos Chrysanthemi 53g Radix Scutellariae 53g Semen Persicae 48g
Radix Aucklandiae 48g Herba Ephedrae 43g Herba Salsolae Collinae 43g Fructus Mori 38g
Cortex Cinnamomi 33g Rhizoma Polygoni Cuspidati 33g Styrax 28g Radix Sophorae Flavescentis 28g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Radix Angelicae Dahuricae 68g Auricularia 58g Radix Puerariae 58g Fructus Lycii 53g
Cortex Moutan 48g Flos Chrysanthemi 48g Radix Scutellariae 48g Semen Persicae 43g
Radix Aucklandiae 43g Herba Ephedrae 38g Herba Salsolae Collinae 38g Fructus Mori 33g
Cortex Cinnamomi 28g Rhizoma Polygoni Cuspidati 28g Styrax 23g Radix Sophorae Flavescentis 23g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.Clinical data:
1, case selection:
As the hydrocephalic Chinese medicine preparation for the treatment of, the routine clinical observation of hydrocephalic 400 that selection is made a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups, treatment group 200 examples, wherein male's 102 examples at random, women's 98 examples, 43～74 years old age, 54.8 years old mean age, the shortest person of the course of disease 4 months, elder 8 years, average 4.1 years.Matched group 200 examples, male's 101 examples wherein, women's 99 examples, 42～73 years old age, 53.5 years old mean age, the shortest person of the course of disease 5 months, elder 9 years, average 4.8 years.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 8 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, severe one can be fully recovered 3～4 courses for the treatment of.
Matched group is taken acetazolamide tablet, every day 3 times, morning, noon and afternoon each 1 time, each 2; Within 12 days, be 1 course for the treatment of, 3 courses for the treatment of of the lighter, severe one can be fully recovered 4～5 courses for the treatment of, and the person of being in a bad way is conventionally invalid.
3, efficacy determination:
(1) cure: intracranial pressure recovers normal, and intelligence is improved, and motion is normal, and body harmony is normal.Sign is improved completely, happy, in high spirits.
(2) effective: intracranial pressure is significantly recovered, intelligence morals are improved, kinestate and coordination of body property improvement.Sign is improved, and mood, spirit are all better.
(3) effective: intracranial pressure is improved, intelligence is improved, and motion and body harmony make moderate progress.Sign takes a turn for the better, and mood and spirit are improved.
(4) invalid: by treating rear sign without any change, symptom is as front.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 83 examples, effective 60 examples, effective 51 examples, invalid 6 examples, cure rate 41.5%, total effective rate 97%.
In matched group, cure 41 examples, effective 46 examples, effective 35 examples, invalid 78 examples, cure rate 20.5%, total effective rate 61%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Peng, man, 48 years old, From Shandong Rizhao people.Patient is because trouble headache, dizzy appearance are felt sick, stupor, and CT is diagnosed as obstructive hydrocephalus.Take Chinese medicine preparation of the present invention, every day 2 times, each 1 time sooner or later, each 2, take after 1 course for the treatment of, symptom alleviates, take 2 courses for the treatment of after CT examination hydrocephalus all disappear.
2, Lu, female, 56 years old, people from Dezhou, Shandong.Patient's aftersensation right side numb limbs and tense tendons of getting up before the several months, walks unstable, and with vomiting.The CT examination of being admitted to hospital demonstration brain essence degree district ventricular system symmetry is obviously expanded, and the visible cerebrospinal fluid of top exosmoses, and centerline construction is placed in the middle, is diagnosed as hydrocephalus, uses multiple Drug therapy, has no sign of improvement.To our hospital afterwards, take Chinese medicine preparation of the present invention, to take after 2 courses for the treatment of, CT examination shows that hydrocephalus disappears substantially, walks very strong, and arm is not numb again, takes Chinese medicine preparation of the present invention after 3 courses for the treatment of, and discomfort all disappears, and all have recovered normal.
3, Zou, man, 69 years old, people from Dalian.Patient occurs that without obvious inducement left limb is weak, and mind is indifferent, and accompanies agraphia, stool, urine incontinence, cranium nest occupying lesion after head CT shows, is thought of as meningioma, the end of month row meningioma resection, in postoperative appearance, disease is increased the weight of high heat, with Multiple Classes of Antibiotics such as " visiing multiple pleasure, safe energy ", treat and suit the medicine to the illness after Supporting Therapy, patient's hyperpyrexia, whole body height edema, give the danger of asking for sick leave, time patient Gao Re 40.5 ℃ of comas, agraphia, can not take food, stiff, locked mouth parched lips, red complexion is red, oliguria, defecate and do not separate for 10th, occasionally have cough.To our hospital afterwards, take Chinese medicine preparation of the present invention after 2 courses for the treatment of, high heat is decorporated gradually, 38 ℃ of body temperature, sweating, hydrouria, stool is separated, and consciousness is recovered gradually, takes Chinese medicine preparation of the present invention after 3 courses for the treatment of, Consciousness, whole body is swollen to disappear, and urine amount is normal, can out-of-bed activity, look into head CT prompting hydrocephalus and reduce, take Chinese medicine preparation of the present invention after 4 courses for the treatment of, look into head CT prompting hydrocephalus and disappear, symptom all disappears.
Claims (5)
1. treat a hydrocephalic Chinese medicine preparation, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
48～83 parts of 53～83 parts of Fructus Lycii of 53～88 parts of Radix Puerariaes of 63～88 portions of Auricularias of the Radix Angelicae Dahuricae
38～73 parts, 43～73 parts of Semen Persicaes of 43～78 parts of Radix Scutellariaes of 43～83 parts of Flos Chrysanthemis of Cortex Moutan
28～58 parts of 33～58 parts of Fructus Mori of 33～63 parts of Herba Salsolae Collinaes of 38～68 portions of Herba Ephedraes of the Radix Aucklandiae
18～43 parts of 18～48 parts of Radix Sophorae Flavescentiss of 23～48 parts of Styrax of 23～53 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
2. a kind of hydrocephalic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
53～78 parts of 58～78 parts of Fructus Lycii of 58～83 parts of Radix Puerariaes of 68～83 portions of Auricularias of the Radix Angelicae Dahuricae
43～68 parts, 48～68 parts of Semen Persicaes of 48～73 parts of Radix Scutellariaes of 48～78 parts of Flos Chrysanthemis of Cortex Moutan
33～53 parts of 38～53 parts of Fructus Mori of 38～58 parts of Herba Salsolae Collinaes of 43～63 portions of Herba Ephedraes of the Radix Aucklandiae
23～38 parts of 23～43 parts of Radix Sophorae Flavescentiss of 28～43 parts of Styrax of 28～48 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
3. a kind of hydrocephalic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
58～73 parts of 63～73 parts of Fructus Lycii of 63～78 parts of Radix Puerariaes of 73～78 portions of Auricularias of the Radix Angelicae Dahuricae
48～63 parts, 53～63 parts of Semen Persicaes of 53～68 parts of Radix Scutellariaes of 53～73 parts of Flos Chrysanthemis of Cortex Moutan
38～48 parts of 43～48 parts of Fructus Mori of 43～53 parts of Herba Salsolae Collinaes of 48～58 portions of Herba Ephedraes of the Radix Aucklandiae
28～33 parts of 28～38 parts of Radix Sophorae Flavescentiss of 33～38 parts of Styrax of 33～43 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
4. a kind of hydrocephalic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
66 parts of 68 parts of Fructus Lycii of 70 parts of Radix Puerariaes of 75 portions of Auricularias of the Radix Angelicae Dahuricae
55 parts, 58 parts of Semen Persicaes of 63 parts of Radix Scutellariaes of 63 parts of Flos Chrysanthemis of Cortex Moutan
43 parts of 45 parts of Fructus Mori of 48 parts of Herba Salsolae Collinaes of 53 portions of Herba Ephedraes of the Radix Aucklandiae
31 parts of 33 parts of Radix Sophorae Flavescentiss of 35 parts of Styrax of 38 parts of Rhizoma Polygoni Cuspidati of Cortex Cinnamomi.
5. as described in claim 1～4 any one, treat a preparation method for hydrocephalic Chinese medicine preparation, it is characterized in that: comprise following processing step:
(1) Radix Angelicae Dahuricae, Auricularia, Radix Puerariae, Styrax and Radix Sophorae Flavescentis decontamination are dried, be placed in mortar and grind into powder, cross 200 order fine powders, standby;
(2) Fructus Lycii, Semen Persicae, Herba Salsolae Collinae and Rhizoma Polygoni Cuspidati are cleaned, immersed 75% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and is condensed into the thick paste that at 60 ℃, relative density is 1.20～1.25, standby;
(3) Cortex Moutan, Flos Chrysanthemi, Radix Scutellariae, the Radix Aucklandiae and Cortex Cinnamomi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 65 ℃, relative density is 1.10～1.12, standby;
(4) get Herba Ephedrae decontamination and put into container, select the refined honey of 0.5 times of amount to add after certain amount of boiling water dilution, drench in Herba Ephedrae and mix thoroughly, moistening, taking-up is placed in parch container, with slow fire heating, fries to buff and when tack-free, take out dry in the air cool, be placed in mortar and grind into powder, cross 160 order fine powders, standby;
(5) Fructus Mori are cleaned, put into container, strand juice, elimination impurity, stays juice standby;
(6) above-mentioned steps (1)～(5) prepared fine powder, thick paste and juice are mixed, utilize modern advanced pharmacy science and technology, make tablet, obtain the hydrocephalic Chinese medicine preparation for the treatment of of the present invention.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306704A (en) * | 2014-11-10 | 2015-01-28 | 李玉刚 | External patch for treating infant hydrocephalus and preparation method |
| CN104398737A (en) * | 2014-11-10 | 2015-03-11 | 李玉刚 | External patch for treating children's hydrocephalus and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485071A (en) * | 2002-09-29 | 2004-03-31 | 殷耀卿 | Medicine for curing hydrocephalus, brain abscess and brain tumor and preparation process thereof |
| CN101850096A (en) * | 2010-01-19 | 2010-10-06 | 泰一和浦（北京）中医药研究院有限公司 | External Chinese medicinal composition for treating hydrocephalus and preparation method thereof |
| CN103417790A (en) * | 2013-07-31 | 2013-12-04 | 泰山医学院 | Traditional Chinese medicine for treatment of cerebral hemorrhage |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1485071A (en) * | 2002-09-29 | 2004-03-31 | 殷耀卿 | Medicine for curing hydrocephalus, brain abscess and brain tumor and preparation process thereof |
| CN101850096A (en) * | 2010-01-19 | 2010-10-06 | 泰一和浦（北京）中医药研究院有限公司 | External Chinese medicinal composition for treating hydrocephalus and preparation method thereof |
| CN103417790A (en) * | 2013-07-31 | 2013-12-04 | 泰山医学院 | Traditional Chinese medicine for treatment of cerebral hemorrhage |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306704A (en) * | 2014-11-10 | 2015-01-28 | 李玉刚 | External patch for treating infant hydrocephalus and preparation method |
| CN104398737A (en) * | 2014-11-10 | 2015-03-11 | 李玉刚 | External patch for treating children's hydrocephalus and preparation method thereof |
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