CN105343498A - Traditional Chinese medicine preparation for moistening lungs and preparation method and uses thereof - Google Patents
Traditional Chinese medicine preparation for moistening lungs and preparation method and uses thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for moistening lungs which comprises the following materials by weight: 150-250 parts of radix glehniae, 350-450 parts of radix rehmanniae praeparata, 100-200 parts of radix ophiopogonis, 100-200 parts of cortex moutan, 150-250 parts of rhizoma dioscoreae, 150-250 parts of fructus corni, 100-200 parts of poria, and 100-200 parts of rhizoma alismatis. The invention also discloses a preparation method of traditional Chinese medicine preparation for moistening lungs and also the uses of the traditional Chinese medicine preparation for moistening lungs in preparing medicine for treating less amount of catamenia. The traditional Chinese preparation has advantages of moistening lungs, less amount of impurities, good absorption, quick therapeutic effects, and convenient administration.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof and application, particularly relate to a kind of Chinese medicine preparation for lung moistening and preparation method thereof and application, belong to technical field of Chinese medicines.
Background technology
Lung is positioned at thoracic cavity, and left and right each, is covered on the heart.Lung has leaflet, the second from left right side three, totally five leaves.Lung meridian lung system (referring to trachea-bronchial epithelial cell etc.) is connected with larynx, nose, therefore claims larynx to be the door of lung, and nose is key outside lung.
The main Physiological Function of lung is that main gas department breathes, and main row water, towards hundred arteries and veins, cures mainly joint.Lung qi reduces to basic operation form with Xuan Fasu.Lung position in the vital organs of the human body is the highest, covers all dirty, therefore has the title of " canopy ".The lobe of the lung is tender and lovely, invading of the not resistance to all heresies of cold and heat dampness; Lung goes up clearing the nasal passage again, outer conjunction fur, closely linked with nature, is subject to exopathogen invasion and attack, therefore has the title of " tender dirty ".
The breathing of lung is not normal, not only affect the generation of the generation of pectoral qi and the gas of the whole body, cause the QI-insufficiency of the whole body, i.e. so-called " deficiency of vital energy ", there is the diseases such as deficient QI being not enough to breathe, low voice timidness due to deficiency of QI, lassitude of the limbs and weakness, and the operation of the gas of impact the whole body, causes the ascending, descending, exiting and entering movement disorder of the gas of each zang-fu differentiation.
At present, have that impurity is many for the Chinese medicine preparation of lung moistening, absorption difference, take effect slow, take the shortcomings such as inconvenience.
Artificially few through amount compared with normal when Hypomenorrhea refers to menstrual onset, how because of caused by the reasons such as blood deficiency, the stagnation of QI, blood stasis, cold coagulation blood vessels, stagnation of phlegm.The etiology and pathology of hypomenorrhea has void to have reality, and the multifactor body of empty person is weak, serious disease, prolonged illness, loses blood or the improper diet and overtiredness impairment of the spleen, or impairment of the kidney due to indulgence in sexual activities, and makes sea of blood virtual loss, reduces through amount; Reality person is many to stop by blood stasis, or phlegm dampness obstruction pattern, and passages through which vital energy circulates blocks, hematogenous blockage, and menses reduce.Menstrual cycle is normal, and through measuring obvious minimizing, even drop is namely clean, or shortens menstrual period less than two days, also lacks person, be called hypomenorrhea, also known as a small amount of menses and menstruating unsmoothly through amount.It is generally acknowledged that hypomenorrhea is in 30 milliliters, is hypomenorrhea.Primary disease is often the prodroma of amenorrhea.Hypomenorrhea can be abnormal and see with the cycle, as menstrual period amount less or later stage amount few.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for lung moistening and preparation method thereof, this Chinese medicine preparation is had can few, the advantage such as good absorbing, instant effect, taking convenience of lung moistening, impurity.
For solving the problems of the technologies described above, a kind of Chinese medicine preparation for lung moistening of the present invention, it comprises the raw material thing of following weight portion: Radix Glehniae 150 ~ 250 parts, Radix Rehmanniae Preparata 350 ~ 450 parts, Radix Ophiopogonis 100 ~ 200 parts, Cortex Moutan 100 ~ 200 parts, Rhizoma Dioscoreae 150 ~ 250 parts, Fructus Corni 150 ~ 250 parts, 100 ~ 200 parts, Poria, Rhizoma Alismatis 100 ~ 200 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and it comprises the raw material thing of following weight portion: Radix Glehniae 180 ~ 220 parts, Radix Rehmanniae Preparata 380 ~ 420 parts, Radix Ophiopogonis 130 ~ 170 parts, Cortex Moutan 130 ~ 170 parts, Rhizoma Dioscoreae 180 ~ 220 parts, Fructus Corni 180 ~ 220 parts, 130 ~ 170 parts, Poria, Rhizoma Alismatis 130 ~ 170 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and it comprises the raw material thing of following weight portion: Radix Glehniae 195 ~ 205 parts, Radix Rehmanniae Preparata 395 ~ 405 parts, Radix Ophiopogonis 145 ~ 155 parts, Cortex Moutan 145 ~ 155 parts, Rhizoma Dioscoreae 195 ~ 205 parts, Fructus Corni 195 ~ 205 parts, 145 ~ 155 parts, Poria, Rhizoma Alismatis 145 ~ 155 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and it comprises the raw material thing of following weight portion: Radix Glehniae 200 parts, Radix Rehmanniae Preparata 400 parts, Radix Ophiopogonis 150 parts, Cortex Moutan 150 parts, Rhizoma Dioscoreae 200 parts, Fructus Corni 200 parts, 150 parts, Poria, Rhizoma Alismatis 150 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and it also comprises the raw material thing of following weight portion: Radix Codonopsis 130 ~ 170 parts, Bulbus Fritillariae Thunbergii 180 ~ 220 parts, Bulbus Lilii 130 ~ 170 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and it also comprises the raw material thing of following weight portion: Radix Codonopsis 150 parts, Bulbus Fritillariae Thunbergii 200 parts, Bulbus Lilii 150 parts.
As improvement of the present invention, this is used for the Chinese medicine preparation of lung moistening, and its dosage form is soft capsule, capsule, granule, tablet.
For solving the problems of the technologies described above, the preparation method of a kind of Chinese medicine preparation for lung moistening of the present invention, the method comprises the steps:
Step 1, the Cortex Moutan of recipe quantity is ground into fine powder, cross 60 ~ 80 mesh sieves, by the soak with ethanol 0.5 ~ 3 hour of 3 ~ 5 times raw-material 70 ~ 90%, heating and refluxing extraction 1 ~ 3 hour, extracts 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract;
Step 2, Cortex Moutan medicinal residues 4 ~ 6 times of raw-material purified water soaked 0.5 ~ 2 hour, heating and refluxing extraction 0.5 ~ 3 hour, extracts 1 ~ 3 time, crosses and filters medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B;
Step 3, the Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 70 ~ 90%, the Rhizoma Dioscoreae of recipe quantity 70 ~ 90% and recipe quantity 70 ~ 90% is ground into fine powder respectively, cross 60 ~ 80 mesh sieves, mix homogeneously, soak 0.5 ~ 3 hour by 6 ~ 10 times of raw-material purified water, heating and refluxing extraction 0.5 ~ 2 hour, extract 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum C;
Step 4, is ground into fine powder respectively by remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria, crosses 60 ~ 80 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, be ground into 100 order fine powders, then add suitable adjuvant to make different dosage forms.
As improvement of the present invention, this is used for the preparation method of the Chinese medicine preparation of lung moistening, also comprises the steps:
Step 5, the Radix Codonopsis of recipe quantity, Bulbus Fritillariae Thunbergii and Bulbus Lilii are ground into respectively 60 ~ 80 order fine powders, mix homogeneously, add 4 ~ 6 times of raw-material purified water to soak 0.5 ~ 2 hour, heating and refluxing extraction 0.5 ~ 1.5 hour, extracts 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum D;
Step 6, mixed homogeneously with mixing fine powders, extractum A, extractum B, extractum C such as Radix Rehmanniae Preparata by extractum D, vacuum drying, is ground into 100 order fine powders, then adds suitable adjuvant to make different dosage forms.
Another object of the present invention is to the application that a kind of Chinese medicine preparation for lung moistening is provided, this kind of Chinese medicine preparation for lung moistening is applied in the medicine of preparation treatment Hypomenorrhea.
The pharmacological action of each crude drug of a kind of Chinese medicine preparation for lung moistening of the present invention is as follows:
Radix Glehniae: cold nature, sweet in the mouth, micro-hardship.Enter lung, spleen channel.Function cures mainly: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Modern pharmacological research finds that the effective ingredient in Radix Glehniae is coumarin and coumarin glycoside, and coumarin and coumarin glycoside have many-sided biological activity, has antibacterial, blood vessel dilating, anticoagulation, the effect such as anticancer.Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata.Sweet in the mouth; Warm in nature.Return liver, kidney channel.Function cures mainly: enrich blood moist; Benefit essence fills out marrow.For blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath.Radix Ophiopogonis: have another name called Radix Ophiopogonis.Property is sweet, and micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Modern pharmacological research shows that ophiopogonin is the principle active component of Radix Ophiopogonis, and ophiopogonin has neuroprotective system, antiinflammatory, enhancing immunity, resists myocardial ischemia, the effect such as arrhythmia, anti-cerebral ischemia damnification, antitumor.Cortex Moutan: GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Modern pharmacological research shows that the principle active component of Cortex Moutan is paeonol and paeoniflorin.Paeonol has analgesia, antibacterial, antiinflammatory, antioxidation, antipyretic and suppress allergic effect.Peoniflorin has the effect of blood vessel dilating, antalgic and sedative, antiinflammatory antiulcer, antipyretic spasmolytic, diuresis.Rhizoma Dioscoreae: property is sweet, flat, nontoxic.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.Fructus Corni function cures mainly: liver and kidney tonifying; Convergence is solid de-.Cure mainly waist to have a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Xian essence spermatorrhea; Frequent micturition; Incessant sweating due to debility; Woman uterine bleeding; Interior-heat is quenched one's thirst; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.Modern pharmacological research shows that loganin is one of main pharmacodynamics composition of Fructus Corni, it has has potentiation to non-specific immunity, macrophage phagocytic function can be promoted, slow down aging, there is good anti-cancer anti-radiation effect, have good antiinflammatory, antibacterial action, in addition antitussive is also had, the effect such as to eliminate the phlegm.Poria: property is sweet, light is flat.GUIXIN, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, invigorating middle warmer spleen invigorating, mind tranquilizing and the heart calming.With harnessing the river, swelling is full, dysuria.With the anorexia and loose stool controlling insufficiency of the spleen leading to overabundance of dampness.With smelting severe palpitation, insomnia forgetfulness etc.Rhizoma Alismatis: property is sweet, cold.Enter kidney, urinary bladder channel.Effect: diuretic, eliminating dampness by diuresis, expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.We's nourishing kidney yin, makes the kidney yin of virtual loss be recovered, and increases again the merit of YIN nourishing and the production of body fluid promoting.Be equipped with lung moistening Radix Ophiopogonis to clear away heart-fire, antipyretic relieving restlessness, nourish strong; Lubrication antiinflammatory, is equipped with Radix Glehniae and grows lung, the combination of 8 kinds of compatibility of drugss, gathers the merit of nourishing kidney lung moistening altogether.
Radix Codonopsis: property is put down, sweet in the mouth.Function cures mainly: the effect with invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.Bulbus Fritillariae Thunbergii function cures mainly: removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.Bulbus Lilii: property is sweet; Micro-hardship; Be slightly cold.GUIXIN, lung meridian.Function cures mainly: nourishing YIN and moistening the lung; Clearing away heart-fire for tranquillization.Main deficiency of YIN chronic cough; Sputum mixed with blood; The calentura later stage; Waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded; Carbuncle; Eczema.In we, add Radix Codonopsis can invigorating the spleen and replenishing QI, increases immunity.Being equipped with Bulbus Fritillariae Thunbergii can removing heat-phlegm.Being equipped with Bulbus Lilii can nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, strengthens the function of lung moistening.
When the recipe ingredient of Chinese medicine preparation employing Radix Glehniae 200 parts, Radix Rehmanniae Preparata 400 parts, Radix Ophiopogonis 150 parts, Cortex Moutan 150 parts, Rhizoma Dioscoreae 200 parts, Fructus Corni 200 parts, 150 parts, Poria, Rhizoma Alismatis 150 parts, best synergism can be played, reach best lung moistening effect, obtain best economic benefit.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 60 ~ 80 mesh sieves, by soak with ethanol, heating and refluxing extraction, paeonol isoreactivity component can be extracted preferably with ethanol, improve absorption efficiency and the therapeutic effect of Chinese medicine preparation.Cortex Moutan medicinal residues purified water is soaked, heating and refluxing extraction, peoniflorin isoreactivity component can be extracted preferably, improve absorption efficiency and the therapeutic effect of Chinese medicine preparation.The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 70 ~ 90%, the Rhizoma Dioscoreae of recipe quantity 70 ~ 90% and recipe quantity 70 ~ 90% is ground into fine powder respectively, cross 60 ~ 80 mesh sieves, mix homogeneously, soak by purified water, heating and refluxing extraction, loganin, coumarin, coumarin glycoside, ophiopogonin isoreactivity component can be extracted preferably, improve absorption efficiency and the therapeutic effect of Chinese medicine preparation.Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, cross 60 ~ 80 mesh sieves, mix homogeneously, the mixing fine powders such as Radix Rehmanniae Preparata are mixed homogeneously with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders, then adds suitable adjuvant to make different dosage forms, Chinese medicine preparation taking convenience can be made, can fast, continue, stably play the effect of lung moistening.
Increase Radix Codonopsis, Bulbus Fritillariae Thunbergii and Bulbus Lilii in the formulation, use purified water heating and refluxing extraction, effective ingredient wherein can be extracted, strengthen effect of nourishing YIN and moistening the lung further.
A kind of Chinese medicine preparation for lung moistening of the present invention has can few, the advantage such as good absorbing, instant effect, taking convenience of lung moistening, impurity.
Detailed description of the invention
Below in conjunction with specific embodiment, embodiment of the present invention are described in detail.Should be appreciated that enforcement of the present invention is not limited to the following examples, any pro forma accommodation make the present invention and/or change all will fall into protection scope of the present invention.
Embodiment 1
Radix Glehniae 150 parts, Radix Rehmanniae Preparata 350 parts, Radix Ophiopogonis 200 parts, Cortex Moutan 100 parts, Rhizoma Dioscoreae 250 parts, Fructus Corni 150 parts, 100 parts, Poria, Rhizoma Alismatis 200 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 60 mesh sieves, by the soak with ethanol 3 hours of 3 times raw-material 90%, heating and refluxing extraction 1 hour, extracts 3 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 4 times of raw-material purified water are soaked 2 hours, heating and refluxing extraction 0.5 hour, extract 3 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 70%, the Rhizoma Dioscoreae of recipe quantity 70% and recipe quantity 70% is ground into fine powder respectively, cross 60 mesh sieves, mix homogeneously, soak 0.5 hour by 6 times of raw-material purified water, heating and refluxing extraction 2 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 60 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders.
Make soft capsule: get suspending agent Cera Flava, be placed in diluent soybean oil, heating for dissolving, after cooling, add above-mentioned medicated powder and wetting agent soybean phospholipid, soft capsule shell is made up of gelatin, purified water, glycerol, PEG400, Brown Ferric Oxide, ethyl hydroxybenzoate.Through colloid mill mixing, sprinkler body is dry, is pressed into soft capsule.
Embodiment 2
Radix Glehniae 180 parts, Radix Rehmanniae Preparata 420 parts, Radix Ophiopogonis 130 parts, Cortex Moutan 130 parts, Rhizoma Dioscoreae 220 parts, Fructus Corni 180 parts, 130 parts, Poria, Rhizoma Alismatis 170 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 70 mesh sieves, by the soak with ethanol 2 hours of 4 times raw-material 80%, heating and refluxing extraction 2 hours, extracts 1 time, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 5 times of raw-material purified water are soaked 1.5 hours, heating and refluxing extraction 1 hour, extract 2 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 80%, the Rhizoma Dioscoreae of recipe quantity 70% and recipe quantity 80% is ground into fine powder respectively, cross 70 mesh sieves, mix homogeneously, soak 1 hour by 7 times of raw-material purified water, heating and refluxing extraction 1 hour, extract 1 time, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 70 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders.
Make capsule: add 5% poloxamer, 12% lactose, 40% low-substituted hydroxypropyl cellulose sodium at above-mentioned medicated powder, mixing, granulate, encapsulated, make capsule.
Embodiment 3
Radix Glehniae 200 parts, Radix Rehmanniae Preparata 400 parts, Radix Ophiopogonis 150 parts, Cortex Moutan 150 parts, Rhizoma Dioscoreae 200 parts, Fructus Corni 200 parts, 150 parts, Poria, Rhizoma Alismatis 150 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 80 mesh sieves, by the soak with ethanol 1.5 hours of 5 times raw-material 80%, heating and refluxing extraction 2 hours, extracts 2 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 6 times of raw-material purified water are soaked 1.5 hours, heating and refluxing extraction 1.5 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 80%, the Rhizoma Dioscoreae of recipe quantity 80% and recipe quantity 80% is ground into fine powder respectively, cross 80 mesh sieves, mix homogeneously, soak 1.5 hours by 8 times of raw-material purified water, heating and refluxing extraction 1.5 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 80 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders.
Make granule: add 5% poloxamer, 12% lactose, 40% low-substituted hydroxypropyl cellulose sodium at above-mentioned medicated powder, mixing, granulate, make granule.
Embodiment 4
Radix Glehniae 205 parts, Radix Rehmanniae Preparata 395 parts, Radix Ophiopogonis 155 parts, Cortex Moutan 155 parts, Rhizoma Dioscoreae 195 parts, Fructus Corni 205 parts, 145 parts, Poria, Rhizoma Alismatis 155 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 80 mesh sieves, by the soak with ethanol 1 hour of 4 times raw-material 85%, heating and refluxing extraction 3 hours, extracts 3 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 4 times of raw-material purified water are soaked 1 hour, heating and refluxing extraction 0.5 hour, extract 3 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 90%, the Rhizoma Dioscoreae of recipe quantity 90% and recipe quantity 90% is ground into fine powder respectively, cross 80 mesh sieves, mix homogeneously, soak 2 hours by 9 times of raw-material purified water, heating and refluxing extraction 0.5 hour, extract 2 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 80 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders.
Make tablet: add 85% ethanol at above-mentioned medicated powder and make wetting agent, cross 12 mesh sieves and granulate, in 80 DEG C of dryings, granulate, film-making, sugar coating, makes tablet.
Embodiment 5
Radix Glehniae 250 parts, Radix Rehmanniae Preparata 450 parts, Radix Ophiopogonis 100 parts, Cortex Moutan 200 parts, Rhizoma Dioscoreae 150 parts, Fructus Corni 250 parts, 200 parts, Poria, Rhizoma Alismatis 100 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 60 mesh sieves, by the soak with ethanol 0.5 hour of 5 times raw-material 75%, heating and refluxing extraction 3 hours, extracts 1 time, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 5 times of raw-material purified water are soaked 0.5 hour, heating and refluxing extraction 3 hours, extract 1 time, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 90%, the Rhizoma Dioscoreae of recipe quantity 70% and recipe quantity 80% is ground into fine powder respectively, cross 60 mesh sieves, mix homogeneously, soak 3 hours by 10 times of raw-material purified water, heating and refluxing extraction 0.5 hour, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 60 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, is ground into 100 order fine powders.
Make dispersible tablet: add 15% microcrystalline Cellulose, 4% crospolyvinylpyrrolidone, 4% lactose at above-mentioned medicated powder, mixing, adds 8% ethanol, soft material processed, cross 40 mesh sieves to granulate, dry, 40 mesh sieve granulate, add 3% crospolyvinylpyrrolidone, tabletting after mixing, makes dispersible tablet.
Embodiment 6
Radix Glehniae 150 parts, Radix Rehmanniae Preparata 350 parts, Radix Ophiopogonis 200 parts, Cortex Moutan 100 parts, Rhizoma Dioscoreae 250 parts, Fructus Corni 150 parts, 100 parts, Poria, Rhizoma Alismatis 200 parts, Radix Codonopsis 130 parts, Bulbus Fritillariae Thunbergii 180, Bulbus Lilii 130 is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 60 mesh sieves, by the soak with ethanol 3 hours of 3 times raw-material 90%, heating and refluxing extraction 1 hour, extracts 3 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 4 times of raw-material purified water are soaked 2 hours, heating and refluxing extraction 0.5 hour, extract 3 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 70%, the Rhizoma Dioscoreae of recipe quantity 70% and recipe quantity 70% is ground into fine powder respectively, cross 60 mesh sieves, mix homogeneously, soak 0.5 hour by 6 times of raw-material purified water, heating and refluxing extraction 2 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
The Radix Codonopsis of recipe quantity, Bulbus Fritillariae Thunbergii and Bulbus Lilii are ground into respectively 60 order fine powders, mix homogeneously, add 4 times of raw-material purified water and soak 0.5 hour, heating and refluxing extraction 1.5 hours, extracts 3 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum D;
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 60 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, extractum D, vacuum drying, is ground into 100 order fine powders.
Make soft capsule: get suspending agent Cera Flava, be placed in diluent soybean oil, heating for dissolving, after cooling, add above-mentioned medicated powder and wetting agent soybean phospholipid, soft capsule shell is made up of gelatin, purified water, glycerol, PEG400, Brown Ferric Oxide, ethyl hydroxybenzoate.Through colloid mill mixing, sprinkler body is dry, is pressed into soft capsule.
Embodiment 7
Radix Glehniae 200 parts, Radix Rehmanniae Preparata 400 parts, Radix Ophiopogonis 150 parts, Cortex Moutan 150 parts, Rhizoma Dioscoreae 200 parts, Fructus Corni 200 parts, 150 parts, Poria, Rhizoma Alismatis 150 parts, Radix Codonopsis 150 parts, Bulbus Fritillariae Thunbergii 200 parts, Bulbus Lilii 150 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 80 mesh sieves, by the soak with ethanol 1.5 hours of 5 times raw-material 80%, heating and refluxing extraction 2 hours, extracts 2 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 6 times of raw-material purified water are soaked 1.5 hours, heating and refluxing extraction 1.5 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 80%, the Rhizoma Dioscoreae of recipe quantity 80% and recipe quantity 80% is ground into fine powder respectively, cross 80 mesh sieves, mix homogeneously, soak 1.5 hours by 8 times of raw-material purified water, heating and refluxing extraction 1.5 hours, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
The Radix Codonopsis of recipe quantity, Bulbus Fritillariae Thunbergii and Bulbus Lilii are ground into respectively 80 order fine powders, mix homogeneously, add 5 times of raw-material purified water and soak 1 hour, heating and refluxing extraction 1 hour, extracts 2 times, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum D;
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 80 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, extractum D, vacuum drying, is ground into 100 order fine powders.
Make granule: add 5% poloxamer, 12% lactose, 40% low-substituted hydroxypropyl cellulose sodium at above-mentioned medicated powder, mixing, granulate, make granule.
Embodiment 8
Radix Glehniae 250 parts, Radix Rehmanniae Preparata 450 parts, Radix Ophiopogonis 100 parts, Cortex Moutan 200 parts, Rhizoma Dioscoreae 150 parts, Fructus Corni 250 parts, 200 parts, Poria, Rhizoma Alismatis 100 parts, Radix Codonopsis 170 parts, Bulbus Fritillariae Thunbergii 220 parts, Bulbus Lilii 170 parts is measured by prescription.
The Cortex Moutan of recipe quantity is ground into fine powder, crosses 60 mesh sieves, by the soak with ethanol 0.5 hour of 5 times raw-material 75%, heating and refluxing extraction 3 hours, extracts 1 time, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract.
Cortex Moutan medicinal residues 5 times of raw-material purified water are soaked 0.5 hour, heating and refluxing extraction 3 hours, extract 1 time, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B.
The Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 90%, the Rhizoma Dioscoreae of recipe quantity 70% and recipe quantity 80% is ground into fine powder respectively, cross 60 mesh sieves, mix homogeneously, soak 3 hours by 10 times of raw-material purified water, heating and refluxing extraction 0.5 hour, extract 3 times, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum C.
The Radix Codonopsis of recipe quantity, Bulbus Fritillariae Thunbergii and Bulbus Lilii are ground into respectively 60 order fine powders, mix homogeneously, add 6 times of raw-material purified water and soak 2 hours, heating and refluxing extraction 1.5 hours, extracts 1 time, crosses and filters medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum D;
Remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria are ground into fine powder respectively, and cross 60 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, extractum D, vacuum drying, is ground into 100 order fine powders.
Make dispersible tablet: add 15% microcrystalline Cellulose, 4% crospolyvinylpyrrolidone, 4% lactose at above-mentioned medicated powder, mixing, adds 8% ethanol, soft material processed, cross 40 mesh sieves to granulate, dry, 40 mesh sieve granulate, add 3% crospolyvinylpyrrolidone, tabletting after mixing, makes dispersible tablet.
Antitussive is tested
The Kun Ming mice being 18-22 gram by 80 body weight is divided into 8 groups at random, often organize 10,1-6 group is given respectively embodiment 1,3, the Chinese medicine preparation being used for lung moistening of 5-8, blank group gives normal saline, positive controls gives dioxopromethazine, equal gastric infusion, below respectively organize administration after 1 hour, single white mice to be placed in the closed glass cover of volume 1 liter, continue to spray into 25% ammonia 20 seconds from bottom with ultrasonic atomizing device, take out white mice and record cough latent period and number of times of coughing in 5 minutes, concrete outcome is in table 1.
Table 1
Experimental result shows, relative to the blank group of normal saline, each administration group all can extend the cough latent period of white mice, all there is significant difference (P<0.01), embodiments of the invention group and dioxopromethazine matched group comparing difference, without significance (P > 0.05), illustrate that its cough suppressing effect is close with dioxopromethazine.Relative to the blank group of normal saline, each administration group all can reduce the cough number of times in the white mice that caused by ammonia 5 minutes, all there is significant difference (P<0.01), embodiments of the invention group and dioxopromethazine matched group comparing difference, without significance (P > 0.05), illustrate that its antitussive effect is close with dioxopromethazine.Visible, the Chinese medicine preparation for lung moistening of the present invention has the effect of good cough-relieving, antitussive, lung moistening.
Antibacterial tests
The Kun Ming mice being 18-22 gram by 90 body weight is divided into 9 groups at random, often organizes 10.By embodiment 1,3, the Chinese medicine preparation being used for lung moistening of 5-8 is dissolved in 5ml water respectively, gives 0.5ml medicament respectively, every day 1 time, continuous 4 days to 1-6 group gavage; 7th group is positive controls, subcutaneous injection penicillin sodium 20,000 u/, every day 1 time, continuous 4 days; 8th group is negative control group, only injection bacterium liquid; 9th group is blank group.Except the 9th group, each treated animal is lumbar injection staphylococcus aureus bacterium liquid 1ml/ simultaneously, and every 1ml is containing 2 × 10
9individual bacterium, observe and add up the death condition of each treated animal in 4 days, concrete outcome is in table 2.
Table 2
Result of the test shows, the white mice of Chinese medicine preparation to infection of staphylococcus aureus for lung moistening of the present invention has obvious therapeutical effect, and the Chinese medicine preparation for lung moistening of the present invention has antibacterial, antiinflammatory action preferably as seen.
Separate heat test
Get 2.4-2.6kg New Zealand white rabbit 100, male and female half and half, give escherichia coli endotoxin auricular vein injection 250mg/kg, before injection, record normal body temperature, injects and surveys each rabbit body temperature in latter 60 minutes, 80 that select temperature rising 0.8-1.2 DEG C, be divided into 8 groups at random.By embodiment 1,3, the Chinese medicine preparation being used for lung moistening of 5-8 is dissolved in 5ml water respectively, gives 0.5ml medicament respectively to 1-6 group gavage; 7th group is positive controls, only gives dipyrone 150mg/; 8th group of not administration, as blank group.1,2,3 and 6 hour New Zealand white rabbit body temperature after record administration, and calculate each New Zealand white rabbit body temperature and the normal body temperature temperature difference, concrete outcome is in table 3.
Table 3
Result of the test shows, the Chinese medicine preparation for lung moistening of the present invention has the effect of antibacterial, heat clearing away preferably.
Clinical experiment
1, Therapeutic Method
A kind of Chinese medicine preparation for lung moistening of the present invention is applied in the treatment of cough due to lung-heat patient.Each 0.6 ~ 1.2 gram, every day 3 times, boiled water is taken after mixing it with water, and serve on 7 days.Withdraw rear curative effect situation.
2, criterion of therapeutical effect
Cure: lung-heat is removed, cough transference cure.
Effective: lung-heat alleviates, cough symptom alleviates.
Invalid: lung-heat, cough symptom do not alleviate.
3, therapeutic outcome
Experimental session treats cough due to lung-heat patient numbers 240 people altogether, and divide into groups 6 groups, often organize 40 people, concrete outcome is in table 4.
Table 4
From table 4, in total treatment numbers 240, healing number is 192 people, and cure rate is 80%, and efficiently individual quantity is 39 people, and effective percentage is 16.25%, and total effective rate is 96.25%, and invalid number is 9 people, and inefficiency is 3.75%.Visible a kind of Chinese medicine preparation for lung moistening of the present invention has good therapeutic effect to cough due to lung-heat patient.
Application experiment
1, Therapeutic Method
A kind of Chinese medicine preparation for lung moistening of the present invention is applied in the treatment of Hypomenorrhea.Each 0.6 ~ 1.2 gram, every day 2 times, boiled water is taken after mixing it with water.Premenstrually take 14 days, serve on 3 cycles.Menstruation in half a year is seen after withdrawing.
2, criterion of therapeutical effect
Cure: menstrual blood volume color recovers normal, and all diseases disappear or substantially disappear.
Effective: to have that menstrual blood volume increases, menstruation natural law increases, menstruation color takes a turn for the better, all diseases alleviates one of situation.
Invalid: menstrual blood volume color anomaly, all diseases do not alleviate.
3, therapeutic outcome
Experimental session treats Hypomenorrhea number 120 people altogether, and divide into groups 6 groups, often organize 20 people, concrete outcome is in table 5.
Table 5
Experiment confirms that a kind of Chinese medicine preparation for lung moistening of the present invention has the effect for the treatment of Hypomenorrhea.
Claims (10)
1. for a Chinese medicine preparation for lung moistening, it is characterized in that: it comprises the raw material thing of following weight portion: Radix Glehniae 150 ~ 250 parts, Radix Rehmanniae Preparata 350 ~ 450 parts, Radix Ophiopogonis 100 ~ 200 parts, Cortex Moutan 100 ~ 200 parts, Rhizoma Dioscoreae 150 ~ 250 parts, Fructus Corni 150 ~ 250 parts, 100 ~ 200 parts, Poria, Rhizoma Alismatis 100 ~ 200 parts.
2. a kind of Chinese medicine preparation for lung moistening according to claim 1, is characterized in that: it comprises the raw material thing of following weight portion: Radix Glehniae 180 ~ 220 parts, Radix Rehmanniae Preparata 380 ~ 420 parts, Radix Ophiopogonis 130 ~ 170 parts, Cortex Moutan 130 ~ 170 parts, Rhizoma Dioscoreae 180 ~ 220 parts, Fructus Corni 180 ~ 220 parts, 130 ~ 170 parts, Poria, Rhizoma Alismatis 130 ~ 170 parts.
3. a kind of Chinese medicine preparation for lung moistening according to claim 2, is characterized in that: it comprises the raw material thing of following weight portion: Radix Glehniae 195 ~ 205 parts, Radix Rehmanniae Preparata 395 ~ 405 parts, Radix Ophiopogonis 145 ~ 155 parts, Cortex Moutan 145 ~ 155 parts, Rhizoma Dioscoreae 195 ~ 205 parts, Fructus Corni 195 ~ 205 parts, 145 ~ 155 parts, Poria, Rhizoma Alismatis 145 ~ 155 parts.
4. a kind of Chinese medicine preparation for lung moistening according to claim 3, is characterized in that: it comprises the raw material thing of following weight portion: Radix Glehniae 200 parts, Radix Rehmanniae Preparata 400 parts, Radix Ophiopogonis 150 parts, Cortex Moutan 150 parts, Rhizoma Dioscoreae 200 parts, Fructus Corni 200 parts, 150 parts, Poria, Rhizoma Alismatis 150 parts.
5. a kind of Chinese medicine preparation for lung moistening according to claim 1, is characterized in that: it also comprises the raw material thing of following weight portion: Radix Codonopsis 130 ~ 170 parts, Bulbus Fritillariae Thunbergii 180 ~ 220 parts, Bulbus Lilii 130 ~ 170 parts.
6. a kind of Chinese medicine preparation for lung moistening according to claim 1, is characterized in that: it also comprises the raw material thing of following weight portion: Radix Codonopsis 150 parts, Bulbus Fritillariae Thunbergii 200 parts, Bulbus Lilii 150 parts.
7., according to a kind of Chinese medicine preparation for lung moistening of claim 1 to 6 described in any one, it is characterized in that: its dosage form is soft capsule, capsule, granule, tablet.
8., according to the preparation method of a kind of Chinese medicine preparation for lung moistening of claim 1 to 7 described in any one, it is characterized in that: the method comprises the steps:
Step 1, the Cortex Moutan of recipe quantity is ground into fine powder, cross 60 ~ 80 mesh sieves, by the soak with ethanol 0.5 ~ 3 hour of 3 ~ 5 times raw-material 70 ~ 90%, heating and refluxing extraction 1 ~ 3 hour, extracts 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure and reclaims ethanol, obtain extractum A by ethanol extract;
Step 2, Cortex Moutan medicinal residues 4 ~ 6 times of raw-material purified water soaked 0.5 ~ 2 hour, heating and refluxing extraction 0.5 ~ 3 hour, extracts 1 ~ 3 time, crosses and filters medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum B;
Step 3, the Poria of the Radix Rehmanniae Preparata of the Radix Glehniae of recipe quantity, Radix Ophiopogonis, Fructus Corni, Rhizoma Alismatis, recipe quantity 70 ~ 90%, the Rhizoma Dioscoreae of recipe quantity 70 ~ 90% and recipe quantity 70 ~ 90% is ground into fine powder respectively, cross 60 ~ 80 mesh sieves, mix homogeneously, soak 0.5 ~ 3 hour by 6 ~ 10 times of raw-material purified water, heating and refluxing extraction 0.5 ~ 2 hour, extract 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, purified water extraction liquid is carried out concentrating under reduced pressure, obtains extractum C;
Step 4, is ground into fine powder respectively by remaining Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Poria, crosses 60 ~ 80 mesh sieves, mix homogeneously, mixs homogeneously mixing fine powders such as Radix Rehmanniae Preparata with extractum A, extractum B, extractum C, vacuum drying, be ground into 100 order fine powders, then add suitable adjuvant to make different dosage forms.
9. the preparation method of a kind of Chinese medicine preparation for lung moistening according to claim 8, is characterized in that: the method also comprises the steps:
Step 5, the Radix Codonopsis of recipe quantity, Bulbus Fritillariae Thunbergii and Bulbus Lilii are ground into respectively 60 ~ 80 order fine powders, mix homogeneously, add 4 ~ 6 times of raw-material purified water to soak 0.5 ~ 2 hour, heating and refluxing extraction 0.5 ~ 1.5 hour, extracts 1 ~ 3 time, cross and filter medicinal residues, merging filtrate, carries out concentrating under reduced pressure by purified water extraction liquid, obtains extractum D;
Step 6, mixed homogeneously with mixing fine powders, extractum A, extractum B, extractum C such as Radix Rehmanniae Preparata by extractum D, vacuum drying, is ground into 100 order fine powders, then adds suitable adjuvant to make different dosage forms.
10. according to a kind of Chinese medicine preparation for the lung moistening application in the medicine of preparation treatment Hypomenorrhea of claim 1 to 7 described in any one.
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| CN106343339A (en) * | 2016-08-26 | 2017-01-25 | 北京徳弘东方健康科技有限公司 | Nutrient composition and making method and application thereof |
| CN108014264A (en) * | 2017-12-29 | 2018-05-11 | 缪荣明 | It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof |
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