CN101322830B - Medicament for treating postpartum depression and preparation method thereof - Google Patents
Medicament for treating postpartum depression and preparation method thereof Download PDFInfo
- Publication number
- CN101322830B CN101322830B CN2008101447657A CN200810144765A CN101322830B CN 101322830 B CN101322830 B CN 101322830B CN 2008101447657 A CN2008101447657 A CN 2008101447657A CN 200810144765 A CN200810144765 A CN 200810144765A CN 101322830 B CN101322830 B CN 101322830B
- Authority
- CN
- China
- Prior art keywords
- portions
- parts
- radix
- medicine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a drug used for curing postnatal depression and a preparation method thereof. Varied ingredients of the drug are weighted in portions as following: 10 portions to 20 portions of radix bupleuri, 10 portions to 20 portions of roots of Chinese angelica, 10 portions to 20 portions of root of herbaceous peopny, 10 portions to 20 portions of root bark of tree paeony, 10 portions to 20 portions of cape jasmine, 10 portions to 20 portions of mentha, 10 portions to 20 portions of poria cocos, 10 portions to 20 portions of rhizome of large-headed atractylodes, 10 portions to 20 portions of root of membranous mile vetch, 10 portions to 20 portions of light wheat, 10 portions to 20 portions of Chinese red date, 10 portions to 20 portions of radix curcumae, 10 portions to 20 portions of nard, 10 portions to 20 portions of lily, 10 portions to 20 portions of dried rhizome of rehmannia, 10 portions to 20 portions of Albizzia julibrissin durazz and 10 portions to 20 portions of licorice root. The drug used for curing the postnatal depression has simple preparation technology, low cost and obvious curative effect and can sooth the liver, reinforce spleen and stomach, clear heat and relieve restlessness, obey hepatic qi, clear healthy and lively vigor and can nourish the blood. The preparation method of the drug of the invention has simple technology, cheap raw materials, good curative effect without any toxicity or side effect, short curing time and good social and economic benefits.
Description
Technical field
The present invention relates to contain medicinal preparation that derives from plant, animal, raw mineral materials and preparation method thereof, particularly a kind of medicine for the treatment of postpartum depression and preparation method thereof.
Background technology
(postpartum depression PPD) is meant that depressive symptom appears in the puerpera in puerperal to postpartum depression, all can produce harmful effect to puerpera and infant physical and mental health, belongs to the neurosis category, has certain cognitive dysfunction.
The pathogenesis of postpartum depression is comparatively complicated, it is generally acknowledged and biological factor that psychosocial factor all has relation.Have research to think, just before giving birth preceding Placenta Hominis steroid secretion discharges and reaches peak, and the puerpera shows as glad, and rapid minimizing of secretion in puerperal causes depression; The Placenta Hominis fetus is divided the puerperium, and the hormone that derives from placenta unit is gone down suddenly, and the imbalance between the estrogen, progestogen also is the key factor that causes depression to take place.The complication in puerperal and the misery brought by childbirth usually make the nervous fear of puerpera with uncomfortable during product.Puerperal, family's support was bad, especially lacked husband and elder's collaboration, and fed the huge change that the baby causes rule of life, usually was the depressed direct factor that takes place.
Postpartum depression is the postpartum depression symptom group of one group of independent existence, feature distinctness.The clinical manifestation of postpartum depression is identical with general depression, and mainly based on depressed, anxiety, pessimistic passive person is less, and part patient shows as gastrointestinal tract, General Symptoms and somatic anxiety such as blunt.Relevant data data according to the WHO issue: world's spirit neuropathy incidence rate significantly rises since 2006, account for the spiritual neuropathy patient of global population 1% and the mentally disturbed numeral of falling ill at present, expectation will rise to second of global disease rank in 2008.Therefore, countries in the world are all actively seeking treatment or are improving the development of efficient, nontoxic, the newtype drug that has no side effect of spiritual neuropathy.In the prevailing medical system of traditional biological medical model, to spiritual neuropathy attention degree deficiency, even if receive treatment rate also only about 35.5% the patient with phychlogical problems of developed country.According to the interrelated data statistics, since two thousand, China's mental disorder sickness rate is ascendant trend year by year.By " Chinese mental sickness classification and diagnostic criteria ", spiritual neuropathy sickness rate such as anxiety neurosis, depression sharply rises among the crowd.The postpartum depression cardinal symptom changes a lot of, and its canonic form is not for there being the on tenterhooks and frightened of definite objective objects and concrete and fixed idea content; The patient feels nervousness, nervous easily all day; Usually be on tenterhooks, walk up and down, even run and shout, also can show as and involuntaryly tremble or shake; Often with perspiration, xerostomia, throat feel oppressed, sensation of oppression over the chest with shortness of breath, dyspnea, perpendicular hair, cardiopalmus, hecticly turn white, the especially two skelasthenia senses etc. of nausea and vomiting, urgent micturition, frequent micturition, dizziness, whole body.Sometimes can find that acra trembles, signs such as tendon reflex is active, tachycardia and platycoria.The course of disease has chronic undulatory property tendency.And the most outstanding clinical manifestation of postpartum depression is depressed, continues at least 2 weeks, and it is bad that the patient often feels mental state, feels down in spirits, or anxiety, agitation, is on tenterhooks; To daily routines forfeiture interest, the happy sense of forfeiture, pinched look is weighed down with anxieties all day; Energy goes down, and usually feels that persistence is tired; Thinking lives does not look like, and severe patient is filled with despair helpless.The patient usually feels that thinking is slack-off, and brain is bad to be made, and the each side ability has all descended, the self-accusation of usually feeling compunction, and self evaluation is low excessively, and is dissatisfied to own everything, and some minor errors, the indisposition of oneself going over are said that all becoming is monstrous crimes.Patient's psychomotor obviously suppresses, association's difficulty, and speech reduces, and voice are overcast, and are slow in action.Nightmare is easily waken up, and early awakening can't be fallen asleep after waking up etc.
At present, the medicine of clinical treatment postpartum depression is many based on chemical drugs both at home and abroad, presses down compositions class medicine, tricyclic antidepressant, Fourth Ring class antidepressants as selectivity 5-hydroxy tryptamine (5-HT) reuptake.Existing anxiety, antidepressant drug have toxicity and side effect, in addition take anxiety for a long time, antidepressant drug may cause problems such as spiritual nervous system disorders, has caused extensive concern.These Drug therapys have multiple higher side effect and more contraindication, patient can not be tolerated and be difficult to reach promising result.Therefore be necessary to develop determined curative effect, have no side effect, no dependence and withdrawal symptom, new drug with low cost to be to adapt to the urgent need in clinical treatment field.Therefore, people begin target diversion Chinese medicine antidepressant.
Summary of the invention
The invention provides a kind of medicine for the treatment of postpartum depression and preparation method thereof, on the basis of traditional medicine in conjunction with clinical experience for many years, adopting modern processing method to make with extra care forms, for the treatment postpartum depression provides curative effect fast, effect is obvious, thorough treatment, not repeatedly, and the Chinese medicine preparation of no side effects and preparation method thereof.
For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of postpartum depression, the ratio of weight and number of various compositions is: 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Cortex Moutans, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Herba Menthaes, 10～20 parts in Poria, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of the Radixs Astragali, 10～20 parts of Fructus Tritici Levis, 10～20 parts of Fructus Jujubaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Et Rhizoma Nardostachyos, 10～20 parts of Bulbus Liliies, 10～20 parts of Radix Rehmanniae, 10～20 parts in Herba Albiziae, 10～20 parts in Radix Glycyrrhizae.
The ratio of weight and number of the various compositions of medicine of described treatment postpartum depression can also be 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Cortex Moutans, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Herba Menthaes, 10～15 parts in Poria, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of the Radixs Astragali, 15～20 parts of Fructus Tritici Levis, 15～20 parts of Fructus Jujubaes, 15～20 parts of Radix Curcumaes, 15～20 parts of Radix Et Rhizoma Nardostachyos, 15～20 parts of Bulbus Liliies, 15～20 parts of Radix Rehmanniae, 15～20 parts in Herba Albiziae, 10～15 parts in Radix Glycyrrhizae.
Described medicine may further include according to 10～20 parts of the Rhizoma Chuanxiongs of ratio of weight and number, 10～20 parts of Vascular aurantiis.
Described medicine also may further include according to 10～20 parts of the Concha Ostreaes of ratio of weight and number.
Described medicine can further include according to 10～20 parts of the Ramulus Cinnamomi of ratio of weight and number.
Described pharmaceutical dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the medicine of postpartum depression, and the preparation of described drug powder may further comprise the steps: with described raw material water brush, wash clean, pull out and dry; Fructus Gardeniae, Radix Et Rhizoma Nardostachyos, Fructus Tritici Levis, Radix Angelicae Sinensis are put into marmite respectively fry into charcoal, respectively it is ground into smalls, sieve with pulverizer; Radix Rehmanniae after will drying, Radix Bupleuri, Herba Albiziae, Radix Glycyrrhizae, Radix Curcumae are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
The preparation method of the medicine of described treatment postpartum depression, the used sieve that sieves can be the 80-100 order.
The preparation method of the medicine of described treatment postpartum depression, the time of pulverizing in pulverizer can be 18～20 minutes.
The preparation method of the medicine of described treatment postpartum depression may further include the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
The medicine processing technology that the present invention treats postpartum depression is simple, and cost is low, and therapeutic effect is obvious, can depressed liver-energy dispersing and QI regulating, and invigorating the spleen and regulating the stomach, clearing heat and relieving fidgetness is along the property of liver, promoting circulation of QI-blood, benefiting blood and regulating blood circulation.Preparation method technology of the present invention is simple, and medicine material is cheap, and good effect has no side effect, and treatment time is short, and is social and good in economic efficiency.
The specific embodiment
The present invention treats in the medicine of postpartum depression and contains abundant nutrition, and plant protein content height in its raw material is rich in several amino acids and trace element.The present invention's Radix Bupleuri the lucid yang sending up resolving depression, depressed liver-energy dispersing and QI regulating " four tones of standard Chinese pronunciation book on Chinese herbal medicine " is said: " main expectorant is full, painful abdominal mass in the breast side of body "." the southern regions of the Yunnan Province book on Chinese herbal medicine " said: " gas of the contrary knot of row Liver Channel ends left side side of body irritability pain, controls married woman's heat in blood and burns warp, can transfer menstruation "." medicine justice " is then said: " mildly bitter flavor, main soothing the liver ".Light clear liter of Radix Bupleuri loose, with property along liver, and promoting circulation of QI-blood, and make it not strongly fragrant; Radix Angelicae Sinensis, Radix Paeoniae Alba benefiting blood and regulating blood circulation; Radix Curcumae, Cortex Moutan blood circulation promoting and blood stasis dispelling, blood-regulating drug must be joined QI regulating medicine, can blood in the stagnation of QI, stasis in the gas, promoting tissue regeneration by removing blood stasis is in harmonious proportion many arteries and veins, active QI and blood, and end all over the body all pains up and down.With the Rhizoma Atractylodis Macrocephalae, Radix Astragali invigorating the spleen and regulating the stomach; Poria, Radix Glycyrrhizae drying dampness to eliminate phlegm, regulate the flow of vital energy and in; With the invigorating middle warmer of Radix Glycyrrhizae QI invigorating, the mediation property of medicine, all medicines are comprehensive, bring out the best in each other, and are total to long memorial liver resolving depression, invigorating the spleen and regulating the stomach, menstruction regulating and pain relieving, the effect of tranquilizing by nourishing the heart.Technical scheme of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the pathogeny and the human body immunity improving power of postpartum depression, with reference to ancient, modern pharmacological research achievement, from motherland's medical treasure-house, filter out that complement consolidates, the natural Chinese medicine of strengthening vital QI to eliminate pathogenic factors,, skim the cream off milk by the theory of Chinese medical science prescription, make its performance promote that yang blood and qi is regulated in the human body, vital organs of the human body twelve channels and collaterals balance, stabilizing the emotions, enhancing self-confidence have the effect of curing and suppressing to postpartum depression.
The raw material that the present invention treats the medicine of postpartum depression contains following composition:
The Radix Bupleuri hardship is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Modern medicine study shows that Radix Bupleuri can activate hypophysis-interrenal system, acts on many links of inflammatory process-ooze out, capillary permeability, inflammatory mediator release, leukoplania, connective tissue proliferation etc.Can also promote immunologic function, strengthen cytophagy, natural killer cell increased functionality, improve the special viral antibody titre, improve lymphocyte and change the nuclear rate, improve the skin delayed hypersensitivity reaction.
Radix Angelicae Sinensis contains basic lactone (ligusiilide), n-butene acyl lactone (n-butylidene phthalide), ferulic acid, nicotinic acid, sucrose and several amino acids, and sesquiterpenoids etc.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores." Treatise on Febrile Disease with Notes ": the arteries and veins person house of blood, all blood all belongs to the heart, all persons of promoting blood circulation must be first reinforcing the heart benefit blood, so Zhang Zhongjing control brothers faint cold, the thready pulse being about to disappear person, with the hardship temperature of Radix Angelicae Sinensis to help painstaking effort.
The Radix Paeoniae Alba contains paeoniflorin, paeonol, paeoniflorin, and benzoic acid is about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.Sichuan product person contains a kind of acidic materials in addition, and staphylococcus aureus is had inhibitory action." not Lu ": clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago.
Cortex Moutan is cold in nature, bitter in the mouth, suffering.Clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.
Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, it is vexed to be used for calentura, and heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles.
Herba Menthae has special fragrance, pungent sense and cool sense, in pharmaceutically being widely used in wind dispelling, anticorrosion, antiinflammatory, analgesia, antipruritic, medicine such as be good for the stomach.Diaphoresis is arranged, the wind heat of loosing and effect such as antipruritic, be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, diseases such as colic, dysentery and scrofula." property of medicine opinion ": remove anger gas, send out antiperspirant malicious, removing blood stasis dysentery relieving, easing joint movement." a thousand pieces of gold dietetic therapy ": but kidney qi, it is clean to make us implication perfume (or spice).The main poison that exorcises evil spirits removes the labor fraud.Tang Materia Medica: main harmful wind, diaphoresis.(controlling) bad odor distention and fullness in the abdomen.Cholera.Dyspepsia does not disappear, the therapeutic method to keep the adverse QI flowing downwards." Treatise on Dietetic Therapy ": pestle juice clothes, go the heart wind heat.
Poria is sweet, light, equal, return lung, stomach, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating is reduced phlegm, mind tranquilizing and the heart calming.Use Poria, its purpose is to mend not lie in and lets out, and the effect of Poria is to let out and does not lie in benefit.The institute of lid gas extremely, water also penetrates everywhere, the institute of gas ends, water does not also have institute incessantly, so its water Xingqi gas of profit is also.Poria can mind calming the strengthening the spleen the kidney invigorating, with the tangible water of its row, the invisible gas of cloth is also.The diuretic circulation of qi promoting rises cloudyly with from sun, and the cloth sun to be changing the moon, gives birth to turbid falling in order to do clear, reaches descendingly outward, is able to tonification also and heart spleen kidney three is dirty.
Rhizoma Atractylodis Macrocephalae hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " record: " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, quench the thirst, and are antiabortive." control cold fluid-retention with Poria, Ramulus Cinnamomi etc.; Be equal to usefulness with the Radix Astragali, Fructus Tritici Levis, the merit of strengthening superficial resistance to stop perspiration is arranged, control the exterior deficiency spontaneous perspiration.
Radix Astragali benefiting QI for strengthening the superficies, strengthening superficial resistance to stop perspiration, the invigorating the spleen and replenishing QI benefit is supported the day after tomorrow, call at " Japan hanako materia medica ": the Radix Astragali helps the gas strengthening bone and muscle, put on flesh and enrich blood ..., modern pharmacological research confirms that body nonspecific immunity humoral immunization, cellular immunization are all had tangible regulating action, promotes the reticuloendothelial system phagocytic effect, improves immune status, increases the resistance of pernicious stimulation to external world.
Fructus Tritici Levis is sweet salty, cold." detailed outline ": " sweet salty, cold, nontoxic." essentials of Matea Medica: " prestige, cold." go into heart channel.Has hidroschesis, the effect of the relieving restlessness of bringing down a fever." book on Chinese herbal medicine converges and says ": Zhuo Dengshan cloud, Fructus Tritici Levis are the skin of Semen Tritici aestivi, withered floating no meat, and the light property of body is dry, and kind all rheumatism of removing are in taste." herbal classic is met former ": the swimmer gram that disappears is held back night sweat, and the heat of getting its diffusing skin knee joint also.
The Fructus Jujubae sweet in the mouth is warm in nature, the taste warp, and invigorating the spleen and replenishing QI is arranged, nourishing blood to tranquillize the mind, the function of the mitigation property of medicine.Modern pharmacological research is existing, and Fructus Jujubae can make oxygen content enhancing in the blood, nourish systemic cell, is the demulcent analeptic of a kind of drug effect.The invigorating the spleen and replenishing QI of Fructus Jujubae energy, strengthening the spleen and stomach reach stimulating appetite, antidiarrheal effect; Benefiting qi and nourishing blood, enhancing immunity; Fructus Jujubae and Radix Glycyrrhizae, the same usefulness of Fructus Tritici Levis can play the effect of nourishing blood to tranquillize the mind, soothing liver-QI for relieving depression, and Fructus Jujubae can reduce the side effect of strong medicine, protection healthy energy, and the protection taste preserve from.
Radix Curcumae suffering, hardship, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Radix Et Rhizoma Nardostachyos suffering, sweet, temperature.Return spleen, stomach warp.Regulating QI to relieve pain, relieving stagnation and activating the spleen.Be used for distension and fullness in the abdomen, inappetence, vomiting.
The Bulbus Lilii sweet and slightly bitter taste, property is flat, goes into the cardiopulmonary warp; Has the disappear effect of heat, clearing away heart-fire for tranquillization of nourishing the lung to arrest cough, yin nourishing; Cure mainly deficiency of YIN chronic cough, sputum mixed with blood, pharyngalgia aphonia; In the calentura later stage, waste heat is unclear, or feelings will is unsuccessful, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded, carbuncle.Bulbus Lilii also contains some special nutritional labelings, as multiple alkaloids such as colchicine except that containing nutrients such as starch, protein, fat and calcium, phosphorus, ferrum, vitamin B1, B2, C.These composition comprehensive functions have the merit of good nutritious tonifying in human body.Say on the traditional Chinese medical science that fresh Bulbus Lilii has tranquilizing by nourishing the heart, the effect of nourishing the lung to arrest cough is highly profitable to weakling after being ill.
Radix Rehmanniae is sweet, bitter, and is cold in nature.GUIXIN, liver, lung meridian.Have the clearing away heat and cooling blood effect and be used for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.Control the epidemic febrile disease later stage, waste heat to the greatest extent, do not hinder, night fever abating at dawn, red tongue rapid pulse by cloudy liquid.Also can be used for controlling the warm febrile disease blood of joining the army, the heat in blood poison is contained, hematemesis and epistaxis, and macule is purple black.The YIN nourishing and the production of body fluid promoting effect, it is thirsty to be used for Tianjin wound, and interior-heat is quenched one's thirst.Control the epidemic febrile disease impairment of YIN, the dryness of the intestine constipation.Contain catalpol, rehmanin (Rehmanin), vitamin A sample material and polysaccharide in addition, still contain amino acids: lysine, histidine, arginine, serine, glutamic acid, valine, leucine, tyrosine, phenylalanine etc.
Herba Albiziae is sweet, flat, nontoxic.Cure mainly lung abscess, traumatic injury, apoplexy contracture etc.
Radix Glycyrrhizae property is flat, and sweet in the mouth has detoxifcation, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Western modern medicine haircut is existing, and the Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance attitude, and mainly as demulcent, relieving cough eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, prolongs the epithelial cell life-span, and anti-inflammatory activity is arranged, and is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
If any the feeling of oppression over the chest and distention of hypochondrium person, in prescription of the present invention, add Rhizoma Chuanxiong, Vascular aurantii among the patient.The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Vascular aurantii is sweet, bitter, put down, return liver,kidney,spleen, stomach warp.The traditional Chinese medical science think Vascular aurantii have relieve internal heat anticancer, collateral dredging reduces phlegm, pleasant merit of invigorating blood circulation, and is not only chronic disease patients' such as chronic bronchitis, coronary heart disease dietetic therapy good merchantable brand, and the pain in chest and hypochondrium that chronic cough is caused is not relaxed and is also had the auxiliary treatment effect.Modern nutriology research is thought, contains a kind of material that is rutosids in the Vascular aurantii.Rutosids can make blood vessel keep normal elasticity and compactness, can reduce the fragility and the permeability of blood vessel wall, has to prevent that the hyperpietic from the effect that retinal hemorrhage takes place for cerebral hemorrhage, glycosuria patient taking place.
If any spontaneous perspiration, night sweat, hyperhidrosis person, in prescription of the present invention, add Concha Ostreae among the patient.Concha Ostreae is salty, is slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Be used for the palpitation with fear insomnia, vertigo and tinnitus, the scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, metrorrhagia and leukorrhagia, stomachache pantothenic acid is restrained astringent or styptic treatment for spontaneous sweating.
If any muscle, joint aches person, in prescription of the present invention, add Ramulus Cinnamomi among the patient.Ramulus Cinnamomi is wind-cold-dispersing medicinal, and to deficiency of yang of liver and kidney, the instability of surface person can dispersing wind and cold, damp-clearing pain-relieving, easing joint movement, the Xin Wentong joint of loosing.
It is auxilliary mutually that the above-mentioned Chinese medicine of respectively distinguishing the flavor of share effect, and having reached can the stomach function regulating spleen invigorating, and liver-smoothing, qi-regulating again can invigorating the spleen and replenishing QI, take good care of painstaking effort, the desirable curative effect that the puerpera is recovered from postpartum depression as early as possible.
The preparation that the present invention treats the drug powder of postpartum depression may further comprise the steps: with described raw material water brush, wash clean, pull out and dry; Fructus Gardeniae, Radix Et Rhizoma Nardostachyos, Fructus Tritici Levis, Radix Angelicae Sinensis are put into marmite respectively fry into charcoal, respectively it is ground into smalls, sieve with pulverizer; Radix Rehmanniae after will drying, Radix Bupleuri, Herba Albiziae, Radix Glycyrrhizae, Radix Curcumae are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.Adopt ultraviolet radiation to carry out disinfection to mixed smalls.The used sieve that sieves is the 80-100 order.The time of pulverizing in pulverizer is 18～20 minutes.
Embodiment 1: Mrs Wang, 28 years old.Puerperal, the patient felt with a heavy heart, and it is bored to live, and can't be happy, and depressed, one day seems like a year, and is painful hard to bear, can not be from dialling anxiety, irritability, nervous.Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Cortex Moutan 10g, Fructus Gardeniae 10g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 10g, Fructus Tritici Levis 20g, Fructus Jujubae 20g, Radix Curcumae 20g, Radix Et Rhizoma Nardostachyos 20g, Bulbus Lilii 10g, Radix Rehmanniae 10g, Herba Albiziae 10g, Radix Glycyrrhizae 10g.
Effect manifests gradually after 1 month, and after 3 months, symptom is alleviated fully, and conditions of patients is stable at present.
Embodiment 2: Mrs Zhao, 31 years old.Puerperal, the patient lost the enthusiasm and the enjoyment of previously life, work, and all interest is dull to anything.Can not experience family happiness, previously hobby is scorned to take even a glance at, and normal closed gate is solitary, becomes estranged kith and kin, social withdrawal.The normal main suit of patient " has not had emotion ", " emotional anesthesia ", " having can't be happy ".Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Cortex Moutan 10g, Fructus Gardeniae 10g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Fructus Tritici Levis 15g, Fructus Jujubae 15g, Radix Curcumae 15g, Radix Et Rhizoma Nardostachyos 15g, Bulbus Lilii 15g, Radix Rehmanniae 15g, Herba Albiziae 15g, Radix Glycyrrhizae 10g.
Take medicine of the present invention and cooperate psychological counseling treatment 3 months, effect is fine, and state of an illness recovery from illness was followed up a case by regular visits to 1 year half, and the state of an illness is recurrence more not.
Embodiment 3: Mrs Li, and 24 years old, patient's energy forfeiture in puerperal, feeling of oppression over the chest and distention of hypochondrium does not have any reason subjectivity and feels deficient in energy.Fatigue and weak, wash wash, life such as clothing minor matter difficulty is hard, unable to do what one wishes.The patient uses " nervous breakdown ", " lose heart ball " always and describes the situation of oneself.Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Cortex Moutan 10g, Fructus Gardeniae 10g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Fructus Tritici Levis 15g, Fructus Jujubae 15g, Radix Curcumae 15g, Radix Et Rhizoma Nardostachyos 15g, Bulbus Lilii 15g, Radix Rehmanniae 15g, Herba Albiziae 15g, Radix Glycyrrhizae 15g, Rhizoma Chuanxiong 10g, Vascular aurantii 10g.
After 2 months, symptom progressively improves, and after 3 months, symptom is alleviated fully, continues to take medicine 1 year, at present stable disease.
Embodiment 4: Mrs Bai, 25 years old, puerperal, the patient continued depressive state, attention difficulty, hypomnesis, slow of understanding, thinking is inaccessible, association is difficult, be slow in action uneasiness, anxiety, anxiety, intense, hyperhidrosis.Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 10g, Cortex Moutan 10g, Fructus Gardeniae 10g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 10g, Fructus Tritici Levis 10g, Fructus Jujubae 10g, Radix Curcumae 10g, Radix Et Rhizoma Nardostachyos 10g, Bulbus Lilii 10g, Radix Rehmanniae 10g, Herba Albiziae 10g, Radix Glycyrrhizae 10g, Concha Ostreae 10g.
After taking medicine 1 month, above symptom is progressively alleviated, and the patient is reflected respond well.After continuing to take medicine 2 months, the symptom complete obiteration.Conditions of patients is stable at present, has prepared to come back on the work position.
Embodiment 5: granddaughter scholar, 23 years old, puerperal patient's loss of appetite, lose weight, inappetence, stomach poor appetite symptom, delicious food no longer has allure, the patient does not think ordinary food and drink or has a nasty taste, like chewing wax, with muscular soreness, joint aches.Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 10g, Cortex Moutan 10g, Fructus Gardeniae 10g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 15g, Fructus Tritici Levis 15g, Fructus Jujubae 15g, Radix Curcumae 15g, Radix Et Rhizoma Nardostachyos 15g, Bulbus Lilii 15g, Radix Rehmanniae 15g, Herba Albiziae 15g, Radix Glycyrrhizae 10g, Ramulus Cinnamomi 10g.
After taking medicine 2 months, emotion begins to come to life, muscle, and the joint aches sense disappears.Rehabilitation holds on and takes medicine 1 year, stable disease as before after 2 months.
Embodiment 6: Mrs He, and 27 years old, puerperal, the patient produced a kind of gloom beyond description with depressed, always felt to have an uncertain future, all unsatisfactory to all, always want to cry, but cry to come out, even run into happy event, also have no happy mood, very interesting listening to the music of past, but just flat and insipid afterwards.The patient knows very well long-term melancholy in a depressed state meeting injury health, can't free but suffer from, and it is bad to cause gradually sleeping, and many bad dreams, inappetence, very pessimistic sometimes.Use following prescription, decoct potion every day, divide sooner or later and take for twice:
Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Cortex Moutan 15g, Fructus Gardeniae 15g, Herba Menthae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Astragali 20g, Fructus Tritici Levis 20g, Fructus Jujubae 20g, Radix Curcumae 20g, Radix Et Rhizoma Nardostachyos 20g, Bulbus Lilii 15g, Radix Rehmanniae 15g, Herba Albiziae 15g, Radix Glycyrrhizae 10g.
After serveing on 2 months, the postpartum depression symptom is alleviated, and it is normal that electrocardiogram recovers.Continue the half a year of taking medicine, state of an illness recovery from illness, not recurrence more so far.
The present invention has depressed liver-energy dispersing and QI regulating, invigorating the spleen and regulating the stomach, and clearing heat and relieving fidgetness is along the property of liver, promoting circulation of QI-blood, the effect of benefiting blood and regulating blood circulation is the pure Chinese medicine product of treatment postpartum depression, by systematic observation 130 routine postpartum depression patients, its total effective rate is 95.4%, wherein, cures 72 examples and accounts for 55.4%; 41 examples that significantly take a turn for the better account for 31.5%; 11 examples that take a turn for the better account for 8.5%.
Claims (7)
1. a medicine for the treatment of postpartum depression is characterized in that, the ratio of weight and number of various compositions is: 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Cortex Moutans, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Herba Menthaes, 10～20 parts in Poria, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of the Radixs Astragali, 10～20 parts of Fructus Tritici Levis, 10～20 parts of Fructus Jujubaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Et Rhizoma Nardostachyos, 10～20 parts of Bulbus Liliies, 10～20 parts of Radix Rehmanniae, 10～20 parts in Herba Albiziae, 10～20 parts in Radix Glycyrrhizae.
2. according to the medicine of the described treatment postpartum depression of claim 1, it is characterized in that, the ratio of weight and number of various compositions is: 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Cortex Moutans, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Herba Menthaes, 10～15 parts in Poria, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of the Radixs Astragali, 15～20 parts of Fructus Tritici Levis, 15～20 parts of Fructus Jujubaes, 15～20 parts of Radix Curcumaes, 15～20 parts of Radix Et Rhizoma Nardostachyos, 15～20 parts of Bulbus Liliies, 15～20 parts of Radix Rehmanniae, 15～20 parts in Herba Albiziae, 10～15 parts in Radix Glycyrrhizae.
3. according to the medicine of claim 1 or 2 described treatment postpartum depression, it is characterized in that described pharmaceutical dosage form is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.
4. the preparation method according to the medicine of the described treatment postpartum depression of claim 3 is characterized in that the preparation of described drug powder may further comprise the steps: with described raw material water brush, wash clean, pull out and dry; Fructus Gardeniae, Radix Et Rhizoma Nardostachyos, Fructus Tritici Levis, Radix Angelicae Sinensis are put into marmite respectively fry into charcoal, respectively it is ground into smalls, sieve with pulverizer; Radix Rehmanniae after will drying, Radix Bupleuri, Herba Albiziae, Radix Glycyrrhizae, Radix Curcumae are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
5. according to the preparation method of the medicine of the described treatment postpartum depression of claim 4, it is characterized in that the used sieve that sieves is the 80-100 order.
6. according to the preparation method of the medicine of the described treatment postpartum depression of claim 4, it is characterized in that the time of pulverizing is 18～20 minutes in pulverizer.
7. according to the preparation method of the medicine of the described treatment postpartum depression of claim 4, it is characterized in that described method further comprises the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101447657A CN101322830B (en) | 2008-07-27 | 2008-07-27 | Medicament for treating postpartum depression and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101447657A CN101322830B (en) | 2008-07-27 | 2008-07-27 | Medicament for treating postpartum depression and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101322830A CN101322830A (en) | 2008-12-17 |
| CN101322830B true CN101322830B (en) | 2011-02-09 |
Family
ID=40186630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101447657A Expired - Fee Related CN101322830B (en) | 2008-07-27 | 2008-07-27 | Medicament for treating postpartum depression and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101322830B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319406A (en) * | 2011-10-10 | 2012-01-18 | 张运林 | Medicament for treating tristimania |
| CN102961629A (en) * | 2012-11-13 | 2013-03-13 | 刘晓燕 | Traditional Chinese medicine composition for preventing postoperative complications of caesarean section and promoting puerperal rehabilitation |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258742B (en) * | 2010-05-27 | 2014-04-23 | 倪健 | Chinese medicinal medicine composition for treating depression and preparation method thereof |
| CN102370663B (en) * | 2010-08-18 | 2012-12-05 | 广州加原医药科技有限公司 | Application of pig nail in preparation of medicine or health product used for treating postnatal depression |
| CN102139086B (en) * | 2011-04-09 | 2012-03-28 | 河南中医学院 | Traditional Chinese medicine for treating liver stagnation and spleen deficiency type post-stroke depression |
| CN102198253B (en) * | 2011-05-27 | 2012-09-05 | 上海市中医医院 | Traditional Chinese medicine composition for resisting depression, and preparation method as well as application thereof |
| CN102836330B (en) * | 2012-09-20 | 2013-09-11 | 张焕君 | Decoction for treating anxiety disorder |
| CN103127481B (en) * | 2012-12-09 | 2014-07-09 | 延安大学 | Drug curing depressive disorder |
| CN104306678A (en) * | 2014-11-07 | 2015-01-28 | 韩乃枝 | Traditional Chinese medicine preparation for treating postpartum depression and preparation method of traditional Chinese medicine preparation |
| CN104522653B (en) * | 2014-12-19 | 2016-05-11 | 杨毅 | A kind ofly treat food and the preparation method that irritability is not dredged |
| CN104623362A (en) * | 2015-01-15 | 2015-05-20 | 汤华淑 | Traditional Chinese medicine composition for treating depression |
| CN105055761A (en) * | 2015-08-06 | 2015-11-18 | 张叶梅 | Traditional Chinese medicine for treatment of qi and blood deficiency type postpartum depression and preparation method thereof |
| CN105148099A (en) * | 2015-10-27 | 2015-12-16 | 贾颖洁 | Traditional Chinese medicine composition decoction for treating postpartum depression and preparation method thereof |
| CN107184832A (en) * | 2017-04-28 | 2017-09-22 | 华益药业科技(安徽)有限公司 | It is a kind of to treat Chinese medicine composition of postpartum depression and preparation method thereof |
| CN108273025A (en) * | 2018-03-27 | 2018-07-13 | 贵州康珠药业有限公司 | It is a kind of to be used to improve plaster of depression and preparation method thereof |
-
2008
- 2008-07-27 CN CN2008101447657A patent/CN101322830B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319406A (en) * | 2011-10-10 | 2012-01-18 | 张运林 | Medicament for treating tristimania |
| CN102319406B (en) * | 2011-10-10 | 2013-05-15 | 张运林 | Medicament for treating tristimania |
| CN102961629A (en) * | 2012-11-13 | 2013-03-13 | 刘晓燕 | Traditional Chinese medicine composition for preventing postoperative complications of caesarean section and promoting puerperal rehabilitation |
| CN102961629B (en) * | 2012-11-13 | 2014-07-02 | 刘晓燕 | Traditional Chinese medicine composition for preventing postoperative complications of caesarean section and promoting puerperal rehabilitation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101322830A (en) | 2008-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101322830B (en) | Medicament for treating postpartum depression and preparation method thereof | |
| CN102580022A (en) | Process for combination of Chinese and western medicinal dexamethasone and absorption of aquatic medicines by skin anatripsis and dietary therapy | |
| CN103432475B (en) | Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof | |
| CN102058715B (en) | Chinese medicine preparation for treating chronic prostatitis and preparation method thereof | |
| CN103405728A (en) | Traditional Chinese medicine composition for treating climacteric syndrome and preparation method thereof | |
| CN104958607A (en) | Traditional Chinese medicine composition for treating burning mouth syndromes of climacteric women and preparation method thereof | |
| CN104689226A (en) | Traditional Chinese medicine composition for treating children with rheumatoid arthritis and preparation method thereof | |
| CN101912551B (en) | Miscarriage-prevention Chinese medicinal composition | |
| CN101700336B (en) | Chinese herba preparation for curing craniocerebra trauma residual headache and preparation method | |
| CN101085306A (en) | Oral administration medicament for treating depression | |
| CN108210791A (en) | For treating the Chinese medicine of gout and preparation method | |
| CN104274754A (en) | Traditional Chinese medicine composition for treating infantile enuresis and preparation method of traditional Chinese medicine composition | |
| CN104888152A (en) | Traditional Chinese medicine preparation for treating postpartum depression and preparation method therefor | |
| CN105497789A (en) | Traditional Chinese medicine preparation for treating poststroke depression and preparation method of traditional Chinese medicine preparation | |
| CN104800771A (en) | Traditional Chinese medicine preparation for treating children sleep terror disorder and preparation method thereof | |
| CN102293964B (en) | Medicine for treating gastric ulcer, and preparation method thereof | |
| CN105999117A (en) | Preparation of traditional Chinese medicine plaster applied to meridian blistering cupping detoxification and using method of traditional Chinese medicine plaster | |
| CN105435190A (en) | Traditional Chinese medicine composition for treating cold-heat jumble asthma and preparation method of traditional Chinese medicine composition | |
| CN104800610A (en) | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof | |
| CN112915148A (en) | A Chinese medicinal composition for treating sexual impotence, premature ejaculation and sexual disorder | |
| CN104825991A (en) | Traditional Chinese medicine preparation for alcoholism induced mental disorder, and preparation method thereof | |
| CN104069341A (en) | Traditional Chinese medicine composition for treating deficiency of qi and blood and preparation method of honeyed bolus | |
| CN103520644B (en) | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition | |
| CN103585372B (en) | Traditional Chinese medicine preparation for treating cerebral palsy | |
| CN104524092A (en) | Traditional Chinese medicine composition for treating nervous tinnitus and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110209 Termination date: 20110727 |