CN102319406A - Medicament for treating tristimania - Google Patents
Medicament for treating tristimania Download PDFInfo
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- CN102319406A CN102319406A CN201110302925A CN201110302925A CN102319406A CN 102319406 A CN102319406 A CN 102319406A CN 201110302925 A CN201110302925 A CN 201110302925A CN 201110302925 A CN201110302925 A CN 201110302925A CN 102319406 A CN102319406 A CN 102319406A
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- QSLMDECMDJKHMQ-GSXCWMCISA-N maprotiline Chemical compound C12=CC=CC=C2[C@@]2(CCCNC)C3=CC=CC=C3[C@@H]1CC2 QSLMDECMDJKHMQ-GSXCWMCISA-N 0.000 description 2
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Abstract
The invention relates to a medicament for treating tristimania in the technical field of Chinese medicines. The medicament comprises the following Chinese herbal medicines in part by weight: 10 to 20 parts of bupleurum, 10 to 20 parts of turmeric root-tuber, 10 to 20 parts of root of red-rooted salvia, 10 to 20 parts of largehead atractylodes rhizome, 10 to 20 parts of rehmannia root, 10 to 20 parts of dwarf lilyturf tuber, 10 to 20 parts of white paeony root, 5 to 10 parts of gleditsia thorn, 5 to 10 parts of eucommia bark, 5 to 10 parts of silktree albizzia bark, 10 to 20 parts of pearl, 5 to 10 parts of dragon's blood, 5 to 10 parts of hairy antler, 5 to 10 parts of notoginseng root, 5 to 10 parts of glossy privet fruit, 5 to 10 parts of polygonum multiflorum thumb. and 5 to 10 parts of dried longan pulp. The medicament is prepared by long-term clinical application and adjustment according to the basic theories of Chinese medicine and the Chinese medicinal modern pharmacological study, is reasonable in compatibility of medicines, and accurate in using amount. The medicament is a pure Chinese medicinal preparation, and has the advantages of eliminating diseases along with obvious curative effect and short treatment period.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of medicine of treating depression.
Background technology
Depression is a kind of common mental sickness, and clinical manifestation is hypothymergasia, and interest lowers, pessimism; Retardation of thinking, action reduces, lack of initiative, self-accusation is from crime; The diet sleep is poor, worries oneself to suffer from various diseases, moves whole body many places discomfort, and suicidal thought and behavior can appear in severe patient; At present, depression has trend occurred frequently, and sickness rate is about 3-5% in China.。
The medicine of treatment depression is many to be main with Western medicine, and DeGrain is easy to generate dependence to medicine, and has a lot of side effect, like headache, xerostomia, feel sick, blurred vision, abnormal liver function etc., anaphylaxis can appear in minority.
Summary of the invention
In order to solve above western medicine DeGrain, problem that side effect is big, the invention provides a kind of by pure Chinese medicine process, the medicine of evident in efficacy, treatment depression that treatment cycle is short.
The present invention realizes in the following manner:
A kind of medicine of treating depression, the weight proportion of raw materials used medicine is following:
Radix Bupleuri 10-20 part, Radix Curcumae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Rehmanniae 10-20 part; Radix Ophiopogonis 10-20 part, Radix Paeoniae Alba 10-20 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part; Cortex Albiziae 5-10 part, Margarita 10-20 part, Sanguis Draxonis 5-10 part, Cornu Cervi Pantotrichum 5-10 part; Radix Notoginseng 5-10 part, Fructus Ligustri Lucidi 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part.
Radix Bupleuri: evacuate and bring down a fever the yang invigorating soothing liver-QI.
Radix Curcumae: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.
Spina Gleditsiae: suffering, temperature.Return liver, stomach warp, the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Cortex Albiziae: nature and flavor are sweet, flat.The merit that resolving depression and blood, mind calming, subduing inflammation are arranged.
Margarita: feel at ease, make eye bright.
Sanguis Draxonis: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.
Cornu Cervi Pantotrichum: return kidney, Liver Channel.Marrow is mended in invigorating kidney-YANG, and bone and muscle strengthening is transferred to dash and appointed, the holder sore.
Radix Notoginseng: warm in nature, sweet in the mouth, little hardship.Hemostasia and dissipation blood stasis, reducing swelling and alleviating pain are used as medicine with root, root stock.
Fructus Ligustri Lucidi: liver and kidney tonifying; Clearind deficient heat; Make eye bright.
Radix Polygoni Multiflori: detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.
Arillus Longan: invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Beneficial effect of the present invention: medicine of the present invention is according to Basic Theories of Chinese Medicine, Chinese medicine modern pharmacological research, and long-term clinical is worked out with the adjustment back, and compatibility is reasonable, and consumption is precise and appropriate; Medicine of the present invention belongs to pure Chinese medicinal preparation, have evident in efficacy, treatment cycle short, can eradicate the advantage of disease.
The specific embodiment
Embodiment 1
A kind of medicine of treating depression, the weight proportion of crude drug is following:
10 parts of Radix Bupleuri, 20 parts of Radix Curcumaes, 10 parts of Radix Salviae Miltiorrhizaes, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts in the Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 10 parts of the Radix Paeoniae Albas, 10 parts of Spina Gleditsiae, 5 parts of the Cortexs Eucommiae, 10 parts of Cortex Albiziaes, 10 parts of Margaritas, 10 parts of Sanguis Draxonis, 5 parts in Cornu Cervi Pantotrichum, 10 parts of Radix Notoginseng, 5 parts of Fructus Ligustri Lucidi, 10 parts of Radix Polygoni Multiflori, 5 parts of Arillus Longans.
Manufacturing method for above mentioned medicine is:
(1) take by weighing raw material in the prescription, place extraction pot, add the water of 8 times of weight, soaked 30 minutes, boiled water decocted 2 hours, filtered, and filtering residue adds the water of 5 times of weight, soaked 30 minutes, and boiled water decocted 2 hours, filtration, merging filtrate;
(2) filtrating is left standstill, got supernatant, heating is concentrated into relative density 1.10 (60 ℃ of surveys), and spray drying (160 ~ 175 ℃ of EATs, 85 ~ 95 ℃ of leaving air temps) gets dry extract;
(3) the gained dry extract is put in order with shaking screen, crossed 80 mesh sieves; The gained defective material that will sieve is in addition pulverized with Highefficientpulverizer, still with the shaking screen arrangement, crosses 80 mesh sieves, and the gained medicated powder that will sieve merges, and mixes 30 minutes with mixer, is distributed into the 3g/ bag, promptly gets after the sterilization.
Usage and consumption: oral, 3 times on the one, each 1 bag.15 days courses of treatment, totally three courses of treatment.
Embodiment 2
A kind of medicine of treating depression, the weight proportion of crude drug is following:
20 parts of Radix Bupleuri, 10 parts of Radix Curcumaes, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in the Radix Rehmanniae, 10 parts of Radix Ophiopogonis, 20 parts of the Radix Paeoniae Albas, 5 parts of Spina Gleditsiae, 10 parts of the Cortexs Eucommiae, 5 parts of Cortex Albiziaes, 20 parts of Margaritas, 5 parts of Sanguis Draxonis, 10 parts in Cornu Cervi Pantotrichum, 5 parts of Radix Notoginseng, 10 parts of Fructus Ligustri Lucidi, 5 parts of Radix Polygoni Multiflori, 10 parts of Arillus Longans.
Method for preparing is with described in the embodiment 1.
Clinical trial result
1, case data
Accept out-patient's 100 examples for medical treatment, meet Chinese mental disorder classification and the diagnostic criteria of the 3rd edition (CCMD-3) depression of diagnostic criteria, 17 Hamilton depressive scales (HAMD) total points >=18 minutes; Wherein male 44 examples; Woman's 56 examples, age 20-30 year 64 examples, 30-40 year 21 examples; 40-50 year 9 examples, 50-60 year 6 examples.Be equally divided into two groups, every group 50 routine patient, the equal zero difference of HAMD total points before two groups of sexes, age, the treatment (P>0.05).Get rid of other organic reasons or drug-induced Secondary cases depressive disorder patient, getting rid of has serious hepatorenal disease and hyperpietic, gets rid of the patient that suicide risk and tendency are arranged according to diagnosis, gets rid of gestation or breast-feeding female.
2, Therapeutic Method
Of the present invention group: the medicine that uses the embodiment of the invention 1 to make, oral, 3 times on the one, each 1 bag, 15 days courses of treatment.
Matched group: use the maprotiline fast, few side effects that proves effective, every day, 250mg divided clothes 2-3 time.
3, efficacy assessment standard
Before treatment with after the treatment, do 17 Hamilton depressive scales (HAMD) respectively; Subtract the observation index of branch with front and back, subtract branch rate >=75% and be recovery from illness, subtract the branch rate and between 50-74%, be marked improvement as curative effect; Subtract the branch rate and be progress at 25-49%, subtracting the branch rate is invalid less than 25%.
4, statistical procedures
All data are carried out statistical procedures with statistics software, and < 0.05 has been judged as statistical significance with P.
5, result
The result sees table 1.
The HAMD total points relatively before and after the table 1 liang group treatment
| Group | Before the treatment | After treating three courses of treatment | After treating six courses of treatment |
| Of the present invention group | 21.54±2.89 | 15.17±3.11 | 6.33±1.84 |
| Matched group | 22.26±4.05 | 19.42±5.66 | 11.27±2.51 |
After treating six courses of treatment, two groups of Comparison of therapeutic are seen table 2.
Table 2 liang group Comparison of therapeutic table
| Group | Recovery from illness | Marked improvement | Progressive | Invalid | Effective percentage |
| Of the present invention group | 21 | 18 | 11 | 0 | 100% |
| Matched group | 16 | 16 | 13 | 5 | 90% |
Can be found out by above clinical effectiveness, be compared to the maprotiline that present use is commonplace, therapeutic effect is good, medicine of the present invention therapeutic effect aspect the treatment depression is better; After treating six courses of treatment; It is more that the HAMD total points subtracts branch, and effective percentage reaches 100%, and have no adverse reaction.
Model case
Case 1: the Ms Zhang, 34 years old, the one tame bank working in Jinan was whenever working Monday is just very frightened; But have very happily during the weekend rest, because of worrying the work of Monday, often have a sleepless night evening before that day, early awakening, working in second day; Office is nervous once advancing, and wants especially to go to toilet, and through good friend's advice, goes hospitalize; Be diagnosed as mild depression, take course of treatment of medicine of the present invention, week-night insomnia, early awakening doing well,improving, treat two courses of treatment again after; The transference cure that Monday working is frightened, nervous, consolidate a course of treatment again after, the doctor judges its recovery from illness.Followed up a case by regular visits to 1 year, and do not have recurrence.
Case 2: Mr. Li once was a College Teachers, and introverted sensitivity is depressed constantly; Developed into afterwards and be reluctant fully to exchange with the people, his frequent early awakening can be waken up several times in midnight, and whole people suspends in mid air seemingly; Sometimes wake up and again can't fall asleep, give free rein to fancy, suicidal tendency is once arranged.Under doctor's guidance, take three courses of treatment of medicine of the present invention, the number of times of waking up midnight obviously reduces, and sleep quality improves a lot, continues to take three courses of treatment, and whole people's is in high spirits a lot, no longer depressed, with the household can be harmonious get along.After continuing to take six courses of treatment, depressive symptom disappears basically, consolidates after three courses of treatment, and it is optimistic that the neighbourhood reflects that he becomes.Followed up a case by regular visits to 1 year, and do not have recurrence.
Claims (1)
1. medicine of treating depression is characterized in that the weight proportion of crude drug is following:
Radix Bupleuri 10-20 part, Radix Curcumae 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Radix Rehmanniae 10-20 part; Radix Ophiopogonis 10-20 part, Radix Paeoniae Alba 10-20 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part; Cortex Albiziae 5-10 part, Margarita 10-20 part, Sanguis Draxonis 5-10 part, Cornu Cervi Pantotrichum 5-10 part; Radix Notoginseng 5-10 part, Fructus Ligustri Lucidi 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029258A CN102319406B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating tristimania |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029258A CN102319406B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating tristimania |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102319406A true CN102319406A (en) | 2012-01-18 |
| CN102319406B CN102319406B (en) | 2013-05-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103029258A Active CN102319406B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating tristimania |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552436A (en) * | 2012-01-10 | 2012-07-11 | 上海市中医医院 | Medicine for treating anxiety and depressive disorder as well as application of medicine |
| CN102836324A (en) * | 2012-09-20 | 2012-12-26 | 李龙飞 | Decoction for treating schizophrenia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322830B (en) * | 2008-07-27 | 2011-02-09 | 麻爱华 | Medicament for treating postpartum depression and preparation method thereof |
-
2011
- 2011-10-10 CN CN2011103029258A patent/CN102319406B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322830B (en) * | 2008-07-27 | 2011-02-09 | 麻爱华 | Medicament for treating postpartum depression and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 蒋受军等: "抗抑郁中药的研究概况", 《中国民族民间医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552436A (en) * | 2012-01-10 | 2012-07-11 | 上海市中医医院 | Medicine for treating anxiety and depressive disorder as well as application of medicine |
| CN102836324A (en) * | 2012-09-20 | 2012-12-26 | 李龙飞 | Decoction for treating schizophrenia |
| CN102836324B (en) * | 2012-09-20 | 2013-11-13 | 李龙飞 | Decoction for treating schizophrenia |
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| CN102319406B (en) | 2013-05-15 |
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Owner name: HU YONGPING Effective date: 20130409 |
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