CN102198241B - Medicine for alleviating nervousness and taking care of sub-health - Google Patents

Medicine for alleviating nervousness and taking care of sub-health Download PDF

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Publication number
CN102198241B
CN102198241B CN2010101331234A CN201010133123A CN102198241B CN 102198241 B CN102198241 B CN 102198241B CN 2010101331234 A CN2010101331234 A CN 2010101331234A CN 201010133123 A CN201010133123 A CN 201010133123A CN 102198241 B CN102198241 B CN 102198241B
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fructus
medicine
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preparing
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CN2010101331234A
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CN102198241A (en
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王忠民
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王忠民
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Abstract

The invention discloses a medicine for alleviating nervousness and taking care of sub-health. Materials of rhizome polygonati, meldar, jujube, mulberry, perilla, bergamot, citron, malt, Poria cocos, lily, lotus plumule, spine date seed are decocted according to a certain weight proportion, and then extracted so as to obtain the medicine which can be prepared into any common oral dosage form. With the functions of soothing the liver and resolving depression, relaxing the chest and regulating qi, nourishing the heart and calming the nerves, as well as tonifying qi and blood, the medicine is of obvious effect in treating sub-health syndromes of chest distress and dysphoria, nervousness, insecurity, insomnia, forgetfulness, inefficiency, lassitude, inappetence and the like, with rapid effect and little toxic side-effect.

Description

The medicine of a kind of keeping tensions down emotion and conditioning subhealthy state

Technical field

The present invention relates to the medicine of a kind of keeping tensions down emotion and conditioning subhealthy state, particularly relate to a kind of with botanical herbs and all be that the Chinese medicine of medicine-food two-purpose is the medicine of subhealth state syndromes such as the Comprehensive Treatment agitation uncomfortable in chest processed of raw material, psychentonia, restless, insomnia forgetfulness, inefficiency, fatigue and weak, inappetence.

Background technology

Nervous and subhealth state are the healthy topics of people's special concern in recent years, and this syndrome is that multiple disease is common, are common phenomena the most in the subhealth state, and being influences patients ' life quality, influences work efficiency, influences able-bodied factor.

Because the continuous increase of operating pressure, economic pressures, thought pressure; People's intense strain continues to increase; Even usually occur lethargy, fatigue and weak, sigh nervous, uncomfortable in chest, agitation not peaceful, restless, be laden with misgivings, insomnia and dreamful sleep, dizzy forgetful, inappetence, menoxenia amenorrhea, decrease in efficiency, quite feel many symptoms such as boring; The appearance of this syndrome, very common in layer of management, brain worker.

These diseases, pathogenesis such as quite weak, malaise like the said depression of liver-QI of the traditional Chinese medical science, insufficiency of the spleen stomach.The appearance of these syndromes influences patient's physical and mental health for a long time, but for some patients, treats and often have no way of doing it, and is difficult to seek the Western medicine of suiting the medicine to the illness fully, some patients is dragged for a long time do not heal.

Even if take Chinese medicine, be difficult to find the Chinese patent medicine of suiting the medicine to the illness fully in the existing medicine.Have the XIAOYAO WAN that suppressing the hyperactive liver nourishes blood, can control stagnation of QI due to depression of the liver blood deficiency such as agitation uncomfortable in chest, but diseases such as the hypodynamia and amnesia of can not retreating; Have the bolus of ten powerful tonics of qi and blood tonifying, can remove insufficiency of vital energy and bloods such as fatigue and weak, but be difficult to calm down many diseases that stagnation of QI due to depression of the liver causes

To the general performance of insufficiency of vital energy and blood, stagnation of QI due to depression of the liver, malaise, tired subhealth state such as forgetful, literature search does not still have such Chinese patent medicine at present.Inventing the medicine of a kind of keeping tensions down emotion and conditioning subhealthy state, treat above-mentioned syndrome and have very strong specific aim, the symptom in early stage of many diseases is eliminated in bud, is the key point of effectively treating subhealth state, also is inventor's main purpose.

Invent a kind of pointed strong, curative effect reliable, diverse in function, the Chinese patent medicine of holding concurrently and transferring all cards, having no side effect, Comprehensive Treatment is the subhealth state of principal character with nervous, fatigue and weak, malaise, is to have very much clinical meaning.

Because this disease course of disease is longer relatively, used medicine must possess effectiveness, safety, and medicine of the present invention has possessed this requirement just.

At present, make a general survey of Chinese medicine and western medicine market, such medicine still belongs to blank.

Summary of the invention

The medicine that the purpose of this invention is to provide a kind of keeping tensions down emotion and conditioning subhealthy state.With traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is criterion, and dispersing the stagnated live-QI to relieve the stagnation of QI is held concurrently to nourish blood, and invigorating the spleen and benefiting QI is helped to nourish heart; Relieving fatigue is aided with to be set upright, and monarch is clearly demarcated, and it is apt to fill a prescription; Dialectically combine with differential diagnosis of diseases; Chinese and Western medicine is closed ginseng, and institute's relevant pharmacological evaluation of medicament modern medicine proves loose nerve and stable nerve, blood yiqi and relieving fatigue, strong body constitution and all diseases of alleviation, proves it and removes the produce effects property and the reliability of intense strain and subhealth state; And every herbal medicine all points out and do not have toxic and side effects, is the good medicine of a kind of keeping tensions down emotion and conditioning subhealthy state.

The present invention realizes with following technical scheme.The medicine of a kind of keeping tensions down emotion and conditioning subhealthy state is characterized in that it is to process with conventional method for preparing with the raw material of following weight parts: Rhizoma Polygonati 10-30 part, Fructus Lycii 10-30 part, Fructus Jujubae 12-30 part, Fructus Mori 12-30 part, Fructus Perillae 10-22 part, Fructus Citri Sarcodactylis 10-25 part, Fructus Citri 10-25 part, Fructus Hordei Germinatus 12-30 part, Poria 15-30 part, Bulbus Lilii 10-25 part, Plumula Nelumbinis 12-22 part, Semen Ziziphi Spinosae 12-25 part.

Above-mentioned raw materials medicine and consumption prescription are the inventors through just drawing with how tame medical institutions associating clinical trials for many years, in above-mentioned amount ranges, all have significant curative effect.

Medicament selection Rhizoma Polygonati of the present invention, Fructus Lycii, Fructus Jujubae, Fructus Mori, Fructus Perillae, Fructus Citri Sarcodactylis, Fructus Citri, Fructus Hordei Germinatus, Poria, Bulbus Lilii, Plumula Nelumbinis, Semen Ziziphi Spinosae carry out compatibility; Each efficacy of drugs produces synergism, thereby reaches the effect of the intense strain of releiving, physical strength reinforcing, tranquilizing by nourishing the heart treatment subhealth state.Rhizoma Polygonati boosting qi and nourishing yin in the side, spleen invigorating lung moistening kidney tonifying, to resisting fatigue, raise immunity; The Fructus Lycii nourishing the liver and kidney, beneficial intensive culture is cloudy, promotes immunologic function; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, muscle strength reinforcing and resistance against diseases; The Fructus Mori YIN nourishing of enriching blood is promoted the production of body fluid and is moisturized, and liver-nourishing kidney-boosting makes eye bright and calms the nerves, and loose nerve is with stable neural; Four combinations, benefiting vital QI and blood, tonifying speen and tonifying kidney lung moistening, enhance immunity ability, strong limbs, relieving fatigue.The Fructus Perillae regulating functional activities of vital QI, suppressing hyperactive liver for descending adverse qi, stabilizing the emotions, raise immunity; Fructus Citri Sarcodactylis depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain; The Fructus Citri alleviating distention in middle-JIAO is regulated the flow of vital energy, invigorating the spleen and regulating the stomach; Fructus Hordei Germinatus soothing liver-QI stomach reinforcing, regulating functional activities of qi; Four medicines are shared, soothing liver and strengthening spleen, and the mediate machine of regulating the flow of vital energy is removed worry, stabilizing the emotions.The Poria invigorating the spleen and benefiting QI, mind tranquilizing and the heart calming, enhance immunity is to defying age; The Bulbus Lilii nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, strengthening body, stabilizing the emotions; The Plumula Nelumbinis reinforcing spleen and kidney, tranquilizing by nourishing the heart, the relieving restlessness breath is hot-tempered; Semen Ziziphi Spinosae tonifying liver mind calming, tonifying YIN promotes the production of body fluid, antalgic and sedative, physical strength reinforcing; Four flavors are assistant mutually, boosting qi and nourishing yin, mind tranquilizing and the heart calming, stabilizing the emotions, strengthening body.The combination of full side, stabilizing the emotions, tranquillizing and allaying excitement, enhance immunity, strengthening body, all medicine cooperations bring out the best in each other, and meet the basic principle of tcm treatment according to syndrome differentiation fully, also meet differential diagnosis of diseases and the dialectical basic characteristic that combines.

Moreover, the pharmacological action of said medicine all has relevant pharmacological research and animal experiment conclusion.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to process dosage form for oral administration.Medicine of the present invention can be ground into powder with crude drug and be mixed into powder, electuary, tablet, granule, oral liquid.Can get active ingredient with being condensed into decocting liquid behind each crude drug decocting, refabrication becomes various oral agents, does not all influence therapeutic effect, does not also limit protection scope of the present invention.

Medicine of the present invention also can adopt semi-bionic extraction (Semi-bionicExtractionmethod; The SBE method), supercritical fluid extraction (SupercriticalFluidExtraction; SFE), microwave extraction (Microwaveextraction), enzyme engineering technology (cellulaseengineeringtech nique), ultrasonic extraction (TheUltrasonicwithdrawsthetech nique), macroporous adsorbent resin method method effective component extractings such as (MacroAbsorptionResin), but these extracting modes all do not limit protection scope of the present invention.

The present invention preferably adopts following capsule formulation and granule.

The method for preparing of said medicine, carry out as follows:

(1) take by weighing raw material in proportion, subsequent use;

(2) with the Rhizoma Polygonati of said weight ratio, Fructus Lycii, Fructus Jujubae, Fructus Mori, Fructus Perillae, Fructus Citri Sarcodactylis, Fructus Citri, Fructus Hordei Germinatus, Poria, Bulbus Lilii, Plumula Nelumbinis, Semen Ziziphi Spinosae 12 flavor medicine decocte with water 5 times, merge decocting liquid then 5 times;

(3) step (2) gained decocting liquid is condensed into extractum;

(4) with extractum dry dry extract;

(5) pulverize the dry extract powdering;

(6) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;

(7) incapsulate.

Each amount of water of described step (2) was not advisable to have powder, decocted 30 minutes at every turn.

Described step (5) gained medicated powder and granule adjuvant commonly used is mixed, process granule.

With filtrate water or alcohol extraction, be condensed into fluid extract, master stream extractum is processed in oven dry in drying baker.

Filtrate is suitably concentrated, handle, directly process the oral liquid of effective ingredient through corrosion-proof and sterilization.

Or the effective ingredient of oral liquid mixed with adjuvant commonly used, process oral liquid.

Or use the effective ingredient of dry extract always adjuvant with granule and mix, process granule.

Medicine of the present invention shows that through clinical use result following advantage is arranged:

1, to select the natural edible-plant medicine for use be raw material in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;

2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found any side effect;

3, medicament composing prescription of the present invention is novel, and compatibility is unique, and is with strong points, has functions such as dispersing the stagnated live-QI to relieve the stagnation of QI, the chest stuffiness relieving are regulated the flow of vital energy, tranquilizing by nourishing the heart, benefiting vital QI and blood;

4, medicine of the present invention not only has excellent curative to subhealth state syndromes such as agitation uncomfortable in chest, psychentonia, restless, insomnia forgetfulness, inefficiency, fatigue and weak, inappetence, and the good preventing health-care effect is also arranged, and the scope of application is extensive;

Subhealth symptoms such as 5, all selected but safety is higher in the kind of Ministry of Public Health regulation medicine-food two-purpose for medicine of the present invention, and treatment brain worker neurasthenia, emotion are confusing can be taken for a long time;

6, medicine of the present invention has the good property taken into account, to subhealth state patient inappetence, be prone to catch a cold, symptom such as blood pressure is higher, have certain therapeutical effect of taking into account;

7, medicine treating both the principal and secondary aspects of a disease of the present invention, curative effect is reliable, takes effect rapidly.

The specific embodiment

Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.

Embodiment 1: the capsule preparation

Rhizoma Polygonati 25kg, Fructus Lycii 30kg, Fructus Jujubae 22kg, Fructus Mori 22kg, Fructus Perillae 15kg, Fructus Citri Sarcodactylis 15kg, Fructus Citri 18kg, Fructus Hordei Germinatus 20kg, Poria 30kg, Bulbus Lilii 15kg, Plumula Nelumbinis 18kg, Semen Ziziphi Spinosae 25kg add the common decoction of water 5 times; Add water was not advisable to have powder at every turn; The each decoction 30 minutes merges 5 times decocting liquid; Decocting liquid through conventional alcohol extraction, is condensed into extractum; Extractum is put into drying baker oven dry back pulverizing be fine powder, and carry out conventional high-temperature sterilization; Fine powder is incapsulated every medicated powder 0.45g.

Embodiment 2: tablet and granule preparation

Rhizoma Polygonati 25kg, Fructus Lycii 30kg, Fructus Jujubae 22kg, Fructus Mori 22kg, Fructus Perillae 15kg, Fructus Citri Sarcodactylis 15kg, Fructus Citri 18kg, Fructus Hordei Germinatus 20kg, Poria 30kg, Bulbus Lilii 15kg, Plumula Nelumbinis 18kg, Semen Ziziphi Spinosae 25kg; Process medicated powder with embodiment 1 said method; Be aided with tablet or granule adjuvant commonly used again and process tablet or granule; Every medicated powder 0.5g of tablet, every bag of 2g of granule.

Clinical drug of the present invention is observed

One, ordinary circumstance and test method

For confirming the clinical efficacy of medicine of the present invention, in February, 2009-2009 year December, patient's 77 examples are selected by observation group, male's 36 examples wherein, women's 41 examples; Age 22-53 year, average 35.4 years old.Matched group 76 examples, male's 33 examples wherein, women's 43 examples; Age 21-55 year, average 36.2 years old.Two groups have comparability through statistical procedures, difference there are no significant meaning (P>0.05).

The treatment group is all taken embodiment 1 medicament capsule, and each 5, every day 3 times; Matched group is taken XIAOYAO WAN, 1 time 9 gram, every day 3 times; 1 of Radix Panacis Quinquefolii buccal tablet 1 time, every day 3 times.Two groups of period in a medicine are all avoided maror, and administration time 14 days was 1 course of treatment, and treatment time is the 1-2 course of treatment.

Two, clinical observation standard

Criterion of therapeutical effect: agitation uncomfortable in chest, psychentonia, restless, insomnia forgetfulness, inefficiency, fatigue and weak, 7 symptoms of inappetence all disappear, and two week of drug withdrawal, the no recidivists in back were produce effects; Disappear more than 3 in above-mentioned 7 symptoms, other sxs are effective; Do not reach produce effects and efficiency index person for invalid.

Three, therapeutic effect analysis

Observation group's produce effects 62 examples, effective 23 examples, invalid 2 examples, total obvious effective rate 80.5%; Matched group produce effects 33 examples, effective 31 examples, invalid 12 examples, total obvious effective rate 43.4%.Two groups of comparing differences have statistical significance (P<0.01).

Claims (7)

1. the medicine of keeping tensions down emotion and conditioning subhealthy state is characterized in that it is to be processed by following raw medicaments in portion by weight:
Rhizoma Polygonati 10-30 part Fructus Lycii 10-30 part Fructus Jujubae 12-30 part Fructus Mori 12-30 part
Fructus Perillae 10-22 part Fructus Citri Sarcodactylis 10-25 part Fructus Citri 10-25 part Fructus Hordei Germinatus 12-30 part
Poria 15-30 part Bulbus Lilii 10-25 part Plumula Nelumbinis 12-22 part Semen Ziziphi Spinosae 12-25 part.
2. method for preparing for preparing the said medicine of claim 1 is characterized in that it may further comprise the steps:
A) take by weighing each crude drug, subsequent use;
B) Rhizoma Polygonati, Fructus Lycii, Fructus Jujubae, Fructus Mori, Fructus Perillae, Fructus Citri Sarcodactylis, Fructus Citri, Fructus Hordei Germinatus, Poria, Bulbus Lilii, Plumula Nelumbinis, the Semen Ziziphi Spinosae 12 flavor medicine water purification with said weight proportion wash back decocte with water 5 times; Add water was not advisable to have powder at every turn; Merge 5 times decoction liquor, cross and filter filtrate;
C) with filtrate water or alcohol extraction, be condensed into fluid extract, master stream extractum is processed in oven dry in drying baker;
D) dry extract is broken into the effective ingredient that powder gets medicine.
3. method for preparing for preparing the said medicine of claim 1 is characterized in that it may further comprise the steps:
A) take by weighing each crude drug, subsequent use;
B) with decocte with water after Rhizoma Polygonati, Fructus Lycii, Fructus Jujubae, Fructus Mori, Fructus Perillae, Fructus Citri Sarcodactylis, Fructus Citri, Fructus Hordei Germinatus, Poria, Bulbus Lilii, Plumula Nelumbinis and the Semen Ziziphi Spinosae 12 flavor medicine water purification flushings of said weight proportion 5 times; Add water was not advisable to have powder at every turn; Merge 5 times decoction liquor, cross and filter filtrate;
C) filtrate is suitably concentrated, handle, directly process the oral liquid of effective ingredient through corrosion-proof and sterilization;
4. method for preparing according to claim 2; It is characterized in that step 2d) effective ingredient of dry extract is reduced to 105 ℃ of maintenances 5 minutes after 110 ℃ keep 10 minutes down; And then be cooled to 100 ℃, kept 5 minutes, be cooled to incapsulate after the room temperature capsule.
5. according to right 3 said process for preparing medicine, it is characterized in that step 3c) effective ingredient of oral liquid is mixed with adjuvant commonly used, process oral liquid.
6. method for preparing according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and tablet adjuvant commonly used are mixed, tabletting becomes tablet.
7. method for preparing according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and granule adjuvant commonly used are mixed, process granule.
CN2010101331234A 2010-03-26 2010-03-26 Medicine for alleviating nervousness and taking care of sub-health CN102198241B (en)

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102784358B (en) * 2012-08-01 2013-10-09 蒋典华 Preparation method of traditional Chinese medicine for treating liver stagnation insomnia
CN103125939A (en) * 2013-03-07 2013-06-05 甘肃复兴厚生物医药科技有限公司 Rhizoma polygonati and lotus seed particles
CN103404845B (en) * 2013-05-27 2015-03-11 胡安然 Special diet for insomnia patients
CN103695257B (en) * 2013-11-12 2015-10-14 张月茹 A kind of Tonic wine with characteristic of medicine food homology
CN104940606A (en) * 2015-06-09 2015-09-30 贵州广济堂药业有限公司 Deer-horn gelatin health product for conditioning eight types of abnormal body constitution
CN105012798A (en) * 2015-08-07 2015-11-04 金冰 Health-care product for preventing and treating sub-health and preparing method thereof
CN107874241A (en) * 2017-10-25 2018-04-06 宁国平衡健康管理有限公司 A kind of health food for improving sleep and preparation method thereof
CN107889996A (en) * 2017-10-25 2018-04-10 宁国平衡健康管理有限公司 A kind of health food for improving memory and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1594534A (en) * 2004-06-28 2005-03-16 张定生 Formulation for primordial qi tonic wine and method for preparing same
CN1772227A (en) * 2005-11-04 2006-05-17 张开钧 Chinese medicine prepn with body balance essence and its prepn process
CN101129784A (en) * 2007-09-17 2008-02-27 张开钧 Traditional Chinese medicine composition for treating endocrine dyscrasia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1594534A (en) * 2004-06-28 2005-03-16 张定生 Formulation for primordial qi tonic wine and method for preparing same
CN1772227A (en) * 2005-11-04 2006-05-17 张开钧 Chinese medicine prepn with body balance essence and its prepn process
CN101129784A (en) * 2007-09-17 2008-02-27 张开钧 Traditional Chinese medicine composition for treating endocrine dyscrasia

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Effective date of registration: 20190725

Address after: 511458 X1301-E2535, No. 106 Fengze East Road, Nansha District, Guangzhou City, Guangdong Province

Patentee after: Yuanshengtai (Guangzhou) Biotechnology Co., Ltd.

Address before: Room 101, Unit 3, Building 4, Hongrun Garden, Xuzhou City, Jiangsu Province, 221008

Patentee before: Wang Zhongmin