CN1994451B - Chinese medicinal composition for treating depression, its preparation method and application - Google Patents

Chinese medicinal composition for treating depression, its preparation method and application Download PDF

Info

Publication number
CN1994451B
CN1994451B CN2006101284862A CN200610128486A CN1994451B CN 1994451 B CN1994451 B CN 1994451B CN 2006101284862 A CN2006101284862 A CN 2006101284862A CN 200610128486 A CN200610128486 A CN 200610128486A CN 1994451 B CN1994451 B CN 1994451B
Authority
CN
China
Prior art keywords
parts
radix
add
semen
chinese medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006101284862A
Other languages
Chinese (zh)
Other versions
CN1994451A (en
Inventor
李江华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TAILONG PHARMACEUTICAL CO Ltd HENAN
Original Assignee
TAILONG PHARMACEUTICAL CO Ltd HENAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TAILONG PHARMACEUTICAL CO Ltd HENAN filed Critical TAILONG PHARMACEUTICAL CO Ltd HENAN
Priority to CN2006101284862A priority Critical patent/CN1994451B/en
Publication of CN1994451A publication Critical patent/CN1994451A/en
Application granted granted Critical
Publication of CN1994451B publication Critical patent/CN1994451B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The invention relates to a Chinese medicinal composition for treating depression, its preparing process and use, wherein the composition comprises the ingredients of curcuma root 100-350 parts, ginkgo leaf 100-150 parts, white peony root 100-350 parts, bupleurum root 50-200 parts, Chinese angelica root 100-150 parts, albizia flower 50-200 parts, morinda root 50-200 parts, tuber fleeceflower stem 100-200 parts, wild or spiny jujuba seed 100-150 parts and seeds of Chinese arborvitae 100-150 parts.

Description

Chinese medicine composition of treatment depression and preparation method thereof and its application
Technical field
The present invention relates to field of medicaments, relate to a kind of Chinese medicine composition that is used for the treatment of depression specifically.
Background technology
Whole world depression sickness rate is about 3.1%, and the patients with depression in the current whole world has about 3.4 hundred million, and approximately average per 20 people just have 1 people once to suffer from depression, are listed in the big mental illness of the first in the world, are only second to the second largest killer of cancer.And China is domestic 3,600 ten thousand patients are arranged approximately also, China constantly raises to the patient diagnosis rate of depression, has reached 15%.Along with rhythm of life is accelerated, life stress strengthens, and people's mental workload generally strengthens, and the depression sickness rate is in continuous increase.Depression is seriously perplexing patient's work and life, has brought tremendous loss for country, family and society.The Western medicine price of present commercially available treatment depression is not only very expensive, and all Western medicine all exist very serious adverse, the patient takes for a long time and can cause lethargy, in a trance, the hypomnesis of brains, and the orthostatic collapse can appear in severe patient, vertebral body is outward syndrome, anaphylaxis, toxic hepatitis, granulocytopenia, disturbance of consciousness, pernicious syndrome, psychomotor excitement or the like.Yet doctors are compelled against one's will, and have to leave the medicine that these make us fearing.And when the points for attention that the patient indicates, side effect, warning and taboo item, can increase the weight of the state of an illness again to the feared state of mind state of medicine in reading description, thus form vicious cycle, bring great misery for patient and family members.China is innovation ability weakness aspect the Western medicine research and development at present, and mainly based on imitated, the Western medicine antidepressants can't be compared with western developed country at all, improves very long process of self innovation ability needs.The Chinese medicine that enhances and glorifies the unique cultural features of a nation energetically comes antidepressant, develops a kind of safe ready clinically, and effect is remarkable, and the mood regulation product that has no side effect again is for vast demander puts the axe in the helve, imperative.
Summary of the invention
Purpose of the present invention is just at above-mentioned existing in prior technology problem and a kind of Chinese medicine composition for the treatment of depression of special development and preparation method thereof and its application.
The secretary is carried according to medicine: Radix Morindae Officinalis is a Rubiaceae Radix Morindae Officinalis platymiscium, be considered to have very strong antidepressant activity, Semen Ginkgo is China distinctive Ginkgoaceae Ginkgo plant, metabolism has certain inhibitory action to the Semen Ginkgo standard extract to dopamine, therefore preferred conventional medicament, in conjunction with the modern pharmacological research achievement, remedy the clinical deficiency of existing antidepressant, can effectively solve the treatment problem of depression.
According to the study, depressed disease is from the beginning of with headed by the stagnation of liver-QI, spirit depressing, and emotional lability belongs to irritability and turns to disease; Distending pain uncomfortable in chest is not relaxed, and above disease often fluctuates because of feelings will stimulates, and this also is the outstanding clinical characters of primary disease.The suitable dispersing the stagnated live-QI to relieve the stagnation of QI of treatment, tranquilizing by nourishing the heart, conditioning feelings will.The present invention just by resolving depression, calm the nerves, nurse one's health feelings will and start with, treating both the principal and secondary aspects of a disease, changed traditional simple soothing liver-QI for relieving depression curative to multifunctional directions such as Comprehensive Treatment development such as conditioning feelings will, the kidney invigorating, not only can treat vexed, anxiety due to the depression direct stimulation, insomnia, symptom such as forgetful, and can obviously improve symptoms such as constipation, climacteric syndrome, neurosis, the sexual hypofunction that depression is followed also improves significantly.Therefore, the present invention adopts Radix Curcumae, Folium Ginkgo, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, Flos Albiziae, Radix Morindae Officinalis, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Semen Platycladi reasonable compatibility, adopts advanced process for refining to process the Chinese medicine composition of treatment depression.
The objective of the invention is to realize by following scheme: the Chinese medicine composition that the present invention treats depression comprises the ingredient of following weight proportion:
Radix Curcumae 100-350 part, Folium Ginkgo 100-150 part, Radix Paeoniae Alba 100-350 part, Radix Bupleuri 50-200 part, Radix Angelicae Sinensis 100-150 part, Flos Albiziae 50-200 part, Radix Morindae Officinalis 50-200 part, Caulis Polygoni Multiflori 100-200 part, Semen Ziziphi Spinosae (parched) 100-150 part, Semen Platycladi 100-150 part.
The preferable amount of the present composition is: 250 parts of Radix Curcumaes, 120 parts of Folium Ginkgos, 250 parts of the Radix Paeoniae Albas, 150 parts of Radix Bupleuri, 120 parts of Radix Angelicae Sinensis, 150 parts of Flos Albiziaes, 150 parts of Radix Morindae Officinaliss, 150 parts of Caulis Polygoni Multiflori, 120 parts of Semen Ziziphi Spinosae (parched)s, 120 parts of Semen Platycladi.
In the present invention, described Chinese medicine composition can be said any dosage form on the pharmaceutics, as: oral liquid, capsule, tablet or granule etc.
Preparation method of the present invention comprises following processing step:
A, being ready to raw material by its proportioning, with the Folium Ginkgo roguing, pulverizing, is 8.0 water extraction Folium Ginkgo with pH, compare (solid: liquid) 1: 40, extraction temperature was 90 ℃, leach 4 times, 3h/ time, concentrated, must Semen Ginkgo extrac;
B, Radix Bupleuri, Radix Morindae Officinalis, Caulis Polygoni Multiflori cutting, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Curcumae shave, with Flos Albiziae, Semen Ziziphi Spinosae (parched), Semen Platycladi mixing decocting secondary, add 10 times of amounts that water is medicine for the first time, fried in shallow oil 1.5 hours, add for the second time 8 times of amounts of water, fried in shallow oil 1.5 hours, and merged decocting liquid twice, filter reconcentration, 60 ℃ of heat surveys down, making its relative density is the extractum of 1.20-1.25;
C, Semen Ginkgo extrac and extractum are merged, mixing slowly adds ethanol, makes to contain the alcohol amount and reach 75%, fully stirs, and leaves standstill 24 hours, filters, and reclaims ethanol to there not being the alcohol flavor, must receive pure cream,
D, technology is made corresponding dosage forms routinely then.
When needs are prepared into oral liquid formulation, to receive pure cream and add water 1: 1, boil 30 minutes, centrifugal, add suitable quantity of water, supernatant is got in low temperature (4-8 ℃) cold preservation 48 hours, adds an amount of stirring of sucrose or correctives and makes dissolving, and regulate pH value to 5.0-7.0, add the water standardize solution, preparation liquid is through fill, sterilization, promptly.
When needs are prepared into solid preparation, will receive pure cream drying, add corresponding adjuvant, make capsule, tablet or granule respectively according to the known conventional method of prior art.
The application of Chinese medicine composition of the present invention in treatment depression medicine can be used for feelings will effectively and not relax, vexed due to the direct stimulations such as stagnation of QI due to depression of the liver, anxiety, insomnia, forgetful, climacteric syndrome, neurosis etc.
In prescription of the present invention, Radix Curcumae, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis cure mainly dispersing the stagnated live-QI to relieve the stagnation of QI, nourishing blood to suppress the hyperactive liver, invigorating the spleen to clear away damp pathogen; Folium Ginkgo, Radix Morindae Officinalis have tangible antidepressant, angst resistance effect, and wherein Radix Morindae Officinalis is mended the gate of vitality, warm the five internal organs, and the kidney tonifying sun dashes to appoint and is taken good care of, the Semen Ginkgo immunity that is significantly improved.Flos Albiziae resolving stagnation for tranquilization in the side, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori have effects such as mind tranquilizing and the heart calming, anti-schizophrenia, physical strength reinforcing.But the Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation makes up and down and leads to, and feelings will is happy.Gather dispersing the stagnated live-QI to relieve the stagnation of QI altogether with top medicine science compatibility, tranquilizing by nourishing the heart, the effect of conditioning feelings will, thus make depression be able to effective treatment.The present invention also can by the prescription requirement, make the Chinese medicine composition of any amount as required.Its production is easy, easily row.
The specific embodiment
The present invention is described further below in conjunction with embodiment:
Embodiment 1
According to prescription, get by weight: Radix Curcumae 250g, Folium Ginkgo 120g Radix Paeoniae Alba 250g, Radix Bupleuri 120g, Radix Angelicae Sinensis 100g, Flos Albiziae 150g, Radix Morindae Officinalis 150g, Caulis Polygoni Multiflori 150g, Semen Ziziphi Spinosae (parched) 120g, Semen Platycladi 120g.With the Folium Ginkgo roguing, pulverize, be 8.0 water extraction Folium Ginkgo with pH, the ratio of solid-liquid is 1: 40, and extraction temperature is 90 ℃, leach 4 times, and 3h/ time, leachate is concentrated, must Semen Ginkgo extrac; With Radix Bupleuri, Radix Morindae Officinalis, Caulis Polygoni Multiflori cutting, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Curcumae shave, with Flos Albiziae, Semen Ziziphi Spinosae (parched), Semen Platycladi mixing and water adding 14600g, decocted 1.5 hours for the first time, pour out medicinal liquid, add water 11680g again, decocted 1.5 hours, and merged decocting liquid twice, filter reconcentration, 60 ℃ down heat survey, making its relative density is 1.20~1.25 extractum.Semen Ginkgo extrac and extractum are merged, add ethanol, make to contain the alcohol amount and reach 75%, left standstill 24 hours, reclaim ethanol to there not being the alcohol flavor.To receive pure cream and add water, low temperature (4-8 ℃) cold preservation 48 hours adds sucrose 300g, regulates pH value to 7.0, adds water and makes 1000ml promptly.Be taking convenience, make 10ml for every, oral, 3 times on the one, each 20ml.
Embodiment 2
According to prescription, get by weight: Radix Curcumae 150g, Folium Ginkgo 120g Radix Paeoniae Alba 300g, Radix Bupleuri 100g, Radix Angelicae Sinensis 150g, Flos Albiziae 150g, Radix Morindae Officinalis 150g, Caulis Polygoni Multiflori 120g, Semen Ziziphi Spinosae (parched) 150g, Semen Platycladi 120g.With the Folium Ginkgo roguing, pulverize, be 8.0 water extraction Folium Ginkgo with pH, the ratio of solid-liquid is 1: 40, and extraction temperature is 90 ℃, leach 4 times, and 3h/ time, leachate is concentrated, must Semen Ginkgo extrac; With Radix Bupleuri, Radix Morindae Officinalis, Caulis Polygoni Multiflori cutting, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Curcumae shave, with Flos Albiziae, Semen Ziziphi Spinosae (parched), bat core mixing and water adding 13900g, decocted 1.5 hours for the first time, pour out medicinal liquid, add water 11120g again, decocted 1.5 hours, and merged decocting liquid twice, filter reconcentration, 60 ℃ down heat survey, making its relative density is 1.20~1.25 extractum.Semen Ginkgo extrac and extractum are merged, add ethanol, make to contain the alcohol amount and reach 75%, left standstill 24 hours, reclaim ethanol to there not being the alcohol flavor.To receive pure cream and take spray drying or vacuum decompression drying, pulverize, and cross 100 mesh sieves and get fine powder.With medicated powder add vegetable oil, paraffin waited colloid mill and mulser, made the abundant suspendible of medicated powder; With certain proportion get gelatin, G ﹠ W dissolves mixing in about 60 ℃, be incubated 1-2 hour, and rubber cement is injected between two blocks of offset plates of soft capsule press, forming with punching block compacting.After making soft gelatin capsule, cooling earlier is fixing, reuse ethanol flush away oil, low temperature (38 ± 2 ℃) drying, get final product 1000 soft capsules.Be taking convenience, every contains principal agent 0.6g, oral, and 3 times on the one, each 4.
Embodiment 3
According to prescription, get by weight: Radix Curcumae 300g, Folium Ginkgo 150g Radix Paeoniae Alba 100g, Radix Bupleuri 100g, Radix Angelicae Sinensis 150g, Flos Albiziae 80g, Radix Morindae Officinalis 100g, Caulis Polygoni Multiflori 150g, Semen Ziziphi Spinosae (parched) 120g, Semen Platycladi 100g.With the Folium Ginkgo roguing, pulverize, be 8.0 water extraction Folium Ginkgo with pH, the ratio of solid-liquid is 1: 40, and extraction temperature is 90 ℃, leach 4 times, and 3h/ time, leachate is concentrated, must Semen Ginkgo extrac; With Radix Bupleuri, Radix Morindae Officinalis, Caulis Polygoni Multiflori cutting, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Curcumae shave, with Flos Albiziae, Semen Ziziphi Spinosae (parched), Semen Platycladi mixing and water adding 12300g, decocted 1.5 hours for the first time, pour out medicinal liquid, add water 9840g again, decocted 1.5 hours, and merged decocting liquid twice, filter reconcentration, 60 ℃ down heat survey, making its relative density is 1.20~1.25 extractum.Semen Ginkgo extrac and extractum are merged, will receive pure cream and take spray drying or vacuum decompression drying, pulverize, cross 100 mesh sieves and get fine powder, it is an amount of to add lactose, starch, dextrin, magnesium stearate, granulates, drying, mixing, and tabletting promptly makes.This product is a Film coated tablets, and every 0.6g is oral, 3 times on the one, and each 2-3 sheet.
The curative effect checking
The medicine of treatment depression of the present invention is made up of Radix Curcumae, Folium Ginkgo, the Radix Paeoniae Alba, Radix Bupleuri, Radix Angelicae Sinensis, Flos Albiziae, Radix Morindae Officinalis, Caulis Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Semen Platycladi, is pure Chinese medicinal preparation.How tame units such as one attached institute of the Henan Province college of traditional Chinese medicine, the 8th the People's Hospital, Zhengzhou City (spiritual section hospital), first Affiliated Hospital of Zhengzhou University, adopt multicenter, random-blind method controlled trial, compared the oral liquid and the maprotiline treatment curative effect of depression of this prescription preparation.This prescription oral liquid group patient 60 examples, maprotiline 56 examples.Adopted Hamilton scale, self rating depressive scale, anxiety self-appraisal scale and clinical global impression scale to evaluate curative effect of medication respectively in 14,28,42 days before medication and after the medication.Two groups of patient's sexes, age and every scale baseline scores have comparability.Treat 6 weekends therapeutic evaluatioies and show, test group and treatment of control group recovery from illness, produce effects, effectively, the nonresponder is respectively 28 examples, 21 examples, 9 examples, 3 examples; 26 examples, 22 examples, 8 examples, 2 examples.Test group obvious effective rate 81.7%, 85.7%, two group of curative effect there was no significant difference of matched group obvious effective rate, P>0.05.
In the research of this prescription oral liquid and trazodone contrast Cure for insomnia, the effective percentage 72.1% and trazodone 78.5% therapeutic equivalence of the insomnia of this prescription oral liquid treatment, P>0.05, two group curative effect there was no significant difference.But the untoward reaction of this prescription oral liquid significantly is less than trazodone P<0.01, and patient's compliance is good.

Claims (8)

1. Chinese medicine composition for the treatment of depression is characterized in that: it is that ingredient by following weight proportion makes through solvent extraction:
Radix Curcumae 100-350 part, Folium Ginkgo 100-150 part, Radix Paeoniae Alba 100-350 part, Radix Bupleuri 50-200 part, Radix Angelicae Sinensis 100-150 part, Flos Albiziae 50-200 part, Radix Morindae Officinalis 50-200 part, Caulis Polygoni Multiflori 100-200 part, Semen Ziziphi Spinosae (parched) 100-150 part, Semen Platycladi 100-150 part.
2. the Chinese medicine composition of treatment depression according to claim 1 is characterized in that: its ingredient is:
250 parts of Radix Curcumaes, 120 parts of Folium Ginkgos, 250 parts of the Radix Paeoniae Albas, 150 parts of Radix Bupleuri, 120 parts of Radix Angelicae Sinensis, 150 parts of Flos Albiziaes, 150 parts of Radix Morindae Officinaliss, 150 parts of Caulis Polygoni Multiflori, 120 parts of Semen Ziziphi Spinosae (parched)s, 120 parts of Semen Platycladi.
3. the Chinese medicine composition of treatment depression according to claim 1 is characterized in that: described Chinese medicine composition is said any dosage form on the pharmaceutics.
4. the Chinese medicine composition of treatment depression according to claim 3 is characterized in that: described dosage form can be oral liquid, capsule, tablet or granule.
5. the preparation method of the Chinese medicine composition of the described treatment depression of claim 1, it is characterized in that: it comprises following processing step:
A, being ready to raw material by its proportioning, with the Folium Ginkgo roguing, pulverizing, is 8.0 water extraction Folium Ginkgo with pH, and solid phase is 1: 40 with the ratio of liquid phase, and extraction temperature is 90 ℃, leach 4 times, and 3h/ time, concentrated, must Semen Ginkgo extrac;
B, Radix Bupleuri, Radix Morindae Officinalis, Caulis Polygoni Multiflori cutting, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Curcumae shave, with Flos Albiziae, Semen Ziziphi Spinosae (parched), Semen Platycladi mixing decocting secondary, add 10 times of amounts that water is medicine for the first time, fried in shallow oil 1.5 hours, add for the second time 8 times of amounts of water, fried in shallow oil 1.5 hours, and merged decocting liquid twice, filter reconcentration, 60 ℃ down heat survey, making its relative density is 1.20~1.25 extractum;
C, Semen Ginkgo extrac and extractum are merged, mixing slowly adds ethanol, makes to contain the alcohol amount and reach 75%, fully stirs, and leaves standstill 24 hours, filters, and reclaims ethanol to there not being the alcohol flavor, must receive pure cream;
D, technology is made oral liquid, capsule, tablet or granule dosage form routinely then.
6. preparation method according to claim 5 is characterized in that: when being prepared into oral liquid formulation, will receiving pure cream and add water 1: 1, boiled 30 minutes, centrifugal, add suitable quantity of water, low temperature (4-8 ℃) cold preservation 48 hours, get supernatant, add an amount of stirring of sucrose or correctives and make dissolving, and regulate pH value, add the water standardize solution to 5.0-7.0, preparation liquid is through fill, sterilization, promptly.
7. preparation method according to claim 5 is characterized in that: when being prepared into solid preparation, with extract or receive pure cream drying, add corresponding adjuvant, make capsule, tablet or granule respectively.
8. claim 1 or 2 or the 3 or 4 described Chinese medicine compositions application in preparation treatment depression medicine.
CN2006101284862A 2006-12-27 2006-12-27 Chinese medicinal composition for treating depression, its preparation method and application Expired - Fee Related CN1994451B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2006101284862A CN1994451B (en) 2006-12-27 2006-12-27 Chinese medicinal composition for treating depression, its preparation method and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2006101284862A CN1994451B (en) 2006-12-27 2006-12-27 Chinese medicinal composition for treating depression, its preparation method and application

Publications (2)

Publication Number Publication Date
CN1994451A CN1994451A (en) 2007-07-11
CN1994451B true CN1994451B (en) 2010-06-02

Family

ID=38249707

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006101284862A Expired - Fee Related CN1994451B (en) 2006-12-27 2006-12-27 Chinese medicinal composition for treating depression, its preparation method and application

Country Status (1)

Country Link
CN (1) CN1994451B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101249246B (en) * 2008-03-13 2010-09-29 盛文化 Proprietary Chinese medicine preparations for curing depression after cerebral infarction
CN101607036B (en) * 2008-06-20 2012-06-27 河北以岭医药研究院有限公司 Application of Chinese medicinal composition on in preparing medicament for treating depression
CN101347524B (en) * 2008-09-05 2010-12-01 天津医科大学 Chinese medicinal composition for treating depression and preparation thereof
CN101417033B (en) * 2008-11-25 2012-06-27 山西省长治精神病院 Traditional Chinese medicine for treating insomnia
CN102258742B (en) * 2010-05-27 2014-04-23 倪健 Chinese medicinal medicine composition for treating depression and preparation method thereof
CN102058787B (en) * 2010-12-21 2012-03-07 中国人民解放军海军医学研究所 Anxiolytic drug and preparation method thereof
CN103720791B (en) * 2013-12-19 2015-11-18 王晓源 A kind of strong medicine preventing and treating post-stroke depression and preparation method thereof
CN105497433A (en) * 2014-11-05 2016-04-20 石友爱 Traditional Chinese medicine for treating depression
CN105878941A (en) * 2016-06-07 2016-08-24 华北理工大学 Traditional Chinese medicine pill for treating melancholic temperament and preparation method thereof
CN106110120A (en) * 2016-07-19 2016-11-16 杜娜 A kind of Chinese medicine composition treating depression
US10722547B2 (en) * 2016-09-02 2020-07-28 Pharmacogenetics Limited Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders
CN108741075A (en) * 2018-06-06 2018-11-06 山东中医药大学 A kind of health care soft capsule and its preparation process improving climacteric women health

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686496A (en) * 2005-04-13 2005-10-26 蒋希民 Medicine for treating neurasthenia and its preparation method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686496A (en) * 2005-04-13 2005-10-26 蒋希民 Medicine for treating neurasthenia and its preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
瞿发林等.中药治疗抑郁症研究进展.实用药物与临床9 1.2006,9(1),57-58.
瞿发林等.中药治疗抑郁症研究进展.实用药物与临床9 1.2006,9(1),57-58. *

Also Published As

Publication number Publication date
CN1994451A (en) 2007-07-11

Similar Documents

Publication Publication Date Title
CN1994451B (en) Chinese medicinal composition for treating depression, its preparation method and application
CN100457176C (en) Chinese medicinal preparation for curriculum of physical and fatigue reducing
CN102198241B (en) Medicine for alleviating nervousness and taking care of sub-health
CN104547486A (en) Traditional Chinese medicine preparation for treating anemia and qi-deficiency weakness and preparation process for traditional Chinese medicine preparation
CN105147847A (en) Drug composition for benefiting qi and nourishing blood
CN102188611B (en) Health-care yellow wine and preparation method thereof
CN102284022A (en) Cough medicament and preparation method thereof
CN101507776B (en) Traditional Chinese medicine preparation for treating kidney deficiency, waist and knees soreness and preparation method thereof
CN101095768B (en) Chinese traditional medicine capsule for treating primary hypertension for persons in middle and old age
CN105796845A (en) Application of medicine composition in preparing medicine for treating female climacteric syndromes
CN101195003B (en) Proprietary Chinese medicine for treating apoplexy and sequela
CN101129492B (en) Traditional Chinese medicine formulated product for treating melancholia
CN103385963B (en) Chinese medicine preparation for treating angina pectoris caused by coronary heart disease
CN105561184A (en) Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof
CN102266481B (en) Chinese medicinal preparation for treating chronic cerebral circulation insufficiency
CN104258351A (en) Traditional Chinese medicine preparation for treating alcoholic cardiomyopathy and preparation method of preparation
CN1111054C (en) Medicine for treating apoplexy and its preparing process
CN105770815A (en) Folium artemisiae argyi-containing traditional Chinese medicine composition for treating postpartum collapse and preparation method thereof
CN105343647A (en) Traditional Chinese medicine preparation for treating neurasthenia
CN105362629A (en) Female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae and preparation method of female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae
CN105362630A (en) Climacteric syndrome treatment pharmaceutical composition and preparation method thereof
CN105343675A (en) Traditional Chinese medicine preparation for treating adiposis and preparation method thereof
CN101850055B (en) Chinese medicament for treating coronary heart diseases
CN101843717B (en) Chinese medicament for treating coronary disease
CN104688855A (en) Coptidis rhizome and donkey-hide glue composition for the treatment of chronic fatigue syndrome and application thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100602

Termination date: 20101227